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Interstitial lung disease animal model

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https://www.readbyqxmd.com/read/27807704/animal-models-of-sarcoidosis
#1
REVIEW
Yijie Hu, Betel Yibrehu, Diana Zabini, Wolfgang M Kuebler
Sarcoidosis is a debilitating, inflammatory, multiorgan, granulomatous disease of unknown cause, commonly affecting the lung. In contrast to other chronic lung diseases such as interstitial pulmonary fibrosis or pulmonary arterial hypertension, there is so far no widely accepted or implemented animal model for this disease. This has hampered our insights into the etiology of sarcoidosis, the mechanisms of its pathogenesis, the identification of new biomarkers and diagnostic tools and, last not least, the development and implementation of novel treatment strategies...
November 2, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27308969/fibrotic-gene-expression-coexists-with-alveolar-proteinosis-in-early-indium-lung
#2
Shuhei Noguchi, Masamitsu Eitoku, Hidenori Kiyosawa, Narufumi Suganuma
Occupational inhalation of indium compounds can cause the so-called "indium lung disease". Most affected individuals show pulmonary alveolar proteinosis (PAP) and fibrotic interstitial lung disease. In animal experiments, inhalation of indium tin oxide or indium oxide has been shown to cause lung damage. However, the mechanisms by which indium compounds lead to indium lung disease remain unknown. In this study, we constructed a mouse model of indium lung disease and analyzed gene expression in response to indium exposure...
August 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27144281/map3k19-is-a-novel-regulator-of-tgf-%C3%AE-signaling-that-impacts-bleomycin-induced-lung-injury-and-pulmonary-fibrosis
#3
Stefen A Boehme, Karin Franz-Bacon, Danielle N DiTirro, Tai Wei Ly, Kevin B Bacon
Idiopathic pulmonary fibrosis (IPF) is a progressive, debilitating disease for which two medications, pirfenidone and nintedanib, have only recently been approved for treatment. The cytokine TGF-β has been shown to be a central mediator in the disease process. We investigated the role of a novel kinase, MAP3K19, upregulated in IPF tissue, in TGF-β-induced signal transduction and in bleomycin-induced pulmonary fibrosis. MAP3K19 has a very limited tissue expression, restricted primarily to the lungs and trachea...
2016: PloS One
https://www.readbyqxmd.com/read/27105895/a-potential-contribution-of-antimicrobial-peptide-ll-37-to-tissue-fibrosis-and-vasculopathy-in-systemic-sclerosis
#4
T Takahashi, Y Asano, K Nakamura, T Yamashita, R Saigusa, Y Ichimura, T Toyama, T Taniguchi, A Yoshizaki, Z Tamaki, Y Tada, M Sugaya, T Kadono, S Sato
BACKGROUND: LL-37 is an antimicrobial peptide with pleiotropic effects on immune system, angiogenesis, and tissue remodeling, which are cardinal pathological events in systemic sclerosis (SSc). OBJECTIVES: To elucidate the potential role of LL-37 in SSc. METHODS: The expression of target molecules was evaluated by immunostaining and quantitative reverse transcription-real time PCR in human and murine skin. The mechanisms regulating LL-37 expression in endothelial cells were examined by gene silencing technique and chromatin immunoprecipitation...
April 23, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27014274/potential-of-pegylated-toll-like-receptor-7-ligands-for-controlling-inflammation-and-functional-changes-in-mouse-models-of-asthma-and-silicosis
#5
Tatiana Paula Teixeira Ferreira, Lívia Lacerda Mariano, Roberta Ghilosso-Bortolini, Ana Carolina Santos de Arantes, Andrey Junior Fernandes, Michelle Berni, Valentina Cecchinato, Mariagrazia Uguccioni, Roberto Maj, Alcide Barberis, Patricia Machado Rodrigues E Silva, Marco Aurélio Martins
Prior investigations show that signaling activation through pattern recognition receptors can directly impact a number of inflammatory lung diseases. While toll-like receptor (TLR) 7 agonists have raised interest for their ability to inhibit allergen-induced pathological changes in experimental asthma conditions, the putative benefit of this treatment is limited by adverse effects. Our aim was to evaluate the therapeutic potential of two PEGylated purine-like compounds, TMX-302 and TMX-306, characterized by TLR7 partial agonistic activity; therefore, the compounds are expected to induce lower local and systemic adverse reactions...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/26914452/phosphate-induced-renal-fibrosis-requires-the-prolyl-isomerase-pin1
#6
Zhong-Jian Shen, Jie Hu, Kazuhiro Shiizaki, Makoto Kuro-o, James S Malter
Tubulo-interstitial fibrosis is a common, destructive endpoint for a variety of kidney diseases. Fibrosis is well correlated with the loss of kidney function in both humans and rodents. The identification of modulators of fibrosis could provide novel therapeutic approaches to reducing disease progression or severity. Here, we show that the peptidyl-prolyl isomerase Pin1 is an important molecular contributor that facilitates renal fibrosis in a well-characterized animal model. While wild-type mice fed a high phosphate diet (HPD) for 8-12 weeks developed calcium deposition, macrophage infiltration and extracellular matrix (ECM) accumulation in the kidney interstitium, Pin1 null mice showed significantly less pathology...
2016: PloS One
https://www.readbyqxmd.com/read/26881215/establishment-of-a-rat-adjuvant-arthritis-interstitial-lung-disease-model
#7
Liu-nan Song, Xiao-dan Kong, Hong-jiang Wang, Li-bin Zhan
INTRODUCTION: Development of an animal model of rheumatoid arthritis-interstitial lung disease (RA-ILD) and improved knowledge of the pathogenesis of RA-ILD may facilitate earlier diagnosis and the development of more effective targeted therapies. METHODS: Adult male Wistar rats were studied in an adjuvant arthritis (AA) model induced by the injection of Freund's complete adjuvant (FCA). Rats were sacrificed on days 7, 14, 21, and 28 after FCA injection. Lung tissue was obtained for histopathological examination and evaluation of Caveolin-1 (Cav-1) and transforming growth factor-β (TGF-β1) protein expression levels...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26824344/integrated-long-non-coding-rna-analyses-identify-novel-regulators-of-epithelial-mesenchymal-transition-in-the-mouse-model-of-pulmonary-fibrosis
#8
Hao Sun, Junjie Chen, Wenyi Qian, Jiang Kang, Jun Wang, Lei Jiang, Li Qiao, Wei Chen, Jinsong Zhang
Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease characterized by aberrant accumulation of fibroblast population and deposition of extra cellular matrix. Increasing evidence support that epithelial-mesenchymal transition (EMT) of alveolar epithelial cells is a critical process in the pathogenesis of IPF. Although delivery of bleomycin to induce acute lung injury is the most well-studied animal model of pulmonary fibrosis, there is considerable interest to pursue other models to understand the common and/or specific pathological mechanisms...
July 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/26782003/recent-advances-in-animal-models-of-systemic-sclerosis
#9
REVIEW
Yoshihide Asano
Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by the three cardinal pathological features, comprising aberrant immune activation, vasculopathy and tissue fibrosis, with unknown etiology. Although many inducible and genetic animal models mimicking the selected aspects of SSc have been well documented, the lack of models encompassing the full clinical manifestations hindered the development and preclinical testing of therapies against this disease. Under this situation, three new genetic animal models have recently been established, such as Fra2 transgenic mice, urokinase-type plasminogen activator receptor deficient mice and Klf5(+/-) ;Fli1(+/-) mice, all of which recapitulate the pathological cascade of SSc...
January 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/26587990/pathology-of-equine-influenza-virus-h3n8-in-murine-model
#10
Selvaraj Pavulraj, Bidhan Chandra Bera, Alok Joshi, Taruna Anand, Meenakshi Virmani, Rajesh Kumar Vaid, Karuppusamy Shanmugasundaram, Baldev Raj Gulati, K Rajukumar, Rajendra Singh, Jyoti Misri, Raj Kumar Singh, Bhupendra Nath Tripathi, Nitin Virmani
Equine influenza viruses (EIV)-H3N8 continue to circulate in equine population throughout the world. They evolve by the process of antigenic drift that leads to substantial change in the antigenicity of the virus, thereby necessitating substitution of virus strain in the vaccines. This requires frequent testing of the new vaccines in the in vivo system; however, lack of an appropriate laboratory animal challenge model for testing protective efficacy of equine influenza vaccine candidates hinders the screening of new vaccines and other therapeutic approaches...
2015: PloS One
https://www.readbyqxmd.com/read/26535643/protective-effect-of-lyophilized-recombinant-human-brain-natriuretic-peptide-on-renal-ischemia-reperfusion-injury-in-mice
#11
X Cao, H Y Xia, T Zhang, L C Qi, B Y Zhang, R Cui, X Chen, Y R Zhao, X Q Li
Brain natriuretic peptide (BNP) has a protective effect on acute injury of the heart, brain, and lung. However, its role in acute kidney injury (AKI) remains unclear. The aim of this study was to investigate the effect of lyophilized recombinant human BNP (lrh-BNP) on AKI and the underlying molecular mechanisms. An experimental model for AKI was established using an ischemia/reperfusion (I/R) procedure. Healthy adult BALB/c mice were randomized to the sham, I/R, and lrh-BNP-treated post-I/R (BNP + I/R) groups...
October 27, 2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26483688/glycyrrhizic-acid-alleviates-bleomycin-induced-pulmonary-fibrosis-in-rats
#12
Lili Gao, Haiying Tang, Huanyu He, Jia Liu, Jingwei Mao, Hong Ji, Hongli Lin, Taihua Wu
Idiopathic pulmonary fibrosis is a progressive and lethal form of interstitial lung disease that lacks effective therapies at present. Glycyrrhizic acid (GA), a natural compound extracted from a traditional Chinese herbal medicine Glycyrrhiza glabra, was recently reported to benefit lung injury and liver fibrosis in animal models, yet whether GA has a therapeutic effect on pulmonary fibrosis is unknown. In this study, we investigated the potential therapeutic effect of GA on pulmonary fibrosis in a rat model with bleomycin (BLM)-induced pulmonary fibrosis...
2015: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/26472246/pulmonary-toxicity-of-indium-tin-oxide-production-facility-particles-in-rats
#13
Melissa A Badding, Natalie R Fix, Marlene S Orandle, Mark W Barger, Katherine M Dunnick, Kristin J Cummings, Stephen S Leonard
Indium-tin oxide (ITO) is used to make transparent conductive coatings for touch-screen and liquid crystal display electronics. Occupational exposures to potentially toxic particles generated during ITO production have increased in recent years as the demand for consumer electronics continues to rise. Previous studies have demonstrated cytotoxicity in vitro and animal models have shown pulmonary inflammation and injury in response to various indium-containing particles. In humans, pulmonary alveolar proteinosis (PAP) and fibrotic interstitial lung disease have been observed in ITO facility workers...
April 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/26425910/delayed-effects-of-acute-radiation-exposure-in-a-murine-model-of-the-h-ars-multiple-organ-injury-consequent-to-10-gy-total-body-irradiation
#14
Joseph L Unthank, Steven J Miller, Ariel K Quickery, Ethan L Ferguson, Meijing Wang, Carol H Sampson, Hui Lin Chua, Matthew R DiStasi, Hailin Feng, Alexa Fisher, Barry P Katz, P Artur Plett, George E Sandusky, Rajendran Sellamuthu, Sasidhar Vemula, Eric P Cohen, Thomas J MacVittie, Christie M Orschell
The threat of radiation exposure from warfare or radiation accidents raises the need for appropriate animal models to study the acute and chronic effects of high dose rate radiation exposure. The goal of this study was to assess the late development of fibrosis in multiple organs (kidney, heart, and lung) in survivors of the C57BL/6 mouse model of the hematopoietic-acute radiation syndrome (H-ARS). Separate groups of mice for histological and functional studies were exposed to a single uniform total body dose between 8...
November 2015: Health Physics
https://www.readbyqxmd.com/read/26324800/coagulation-and-anticoagulation-in-idiopathic-pulmonary-fibrosis
#15
REVIEW
Michael G Crooks, Simon P Hart
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events. Coagulation and fibrinolytic systems play central roles in wound healing and repair, processes hypothesised to be abnormal within the IPF lung. Animal models of pulmonary fibrosis have demonstrated an imbalance between thrombosis and fibrinolysis within the alveolar compartment, a finding that is also observed in IPF patients...
September 2015: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/26317335/cd8-t-cell-response-to-gammaherpesvirus-infection-mediates-inflammation-and-fibrosis-in-interferon-gamma-receptor-deficient-mice
#16
Brigid M O'Flaherty, Caline G Matar, Brian S Wakeman, AnaPatricia Garcia, Carol A Wilke, Cynthia L Courtney, Bethany B Moore, Samuel H Speck
Idiopathic pulmonary fibrosis (IPF), one of the most severe interstitial lung diseases, is a progressive fibrotic disorder of unknown etiology. However, there is growing appreciation for the role of viral infection in disease induction and/or progression. A small animal model of multi-organ fibrosis, which involves murine gammaherpesvirus (MHV68) infection of interferon gamma receptor deficient (IFNγR-/-) mice, has been utilized to model the association of gammaherpesvirus infections and lung fibrosis. Notably, several MHV68 mutants which fail to induce fibrosis have been identified...
2015: PloS One
https://www.readbyqxmd.com/read/26266827/role-of-b-cell-activating-factor-in-chronic-obstructive-pulmonary-disease
#17
Leen J M Seys, Fien M Verhamme, Anja Schinwald, Hamida Hammad, Danen Mootoosamy Cunoosamy, Claudie Bantsimba-Malanda, Alan Sabirsh, Eileen McCall, Liz Flavell, Ronald Herbst, Sharen Provoost, Bart N Lambrecht, Guy F Joos, Guy G Brusselle, Ken R Bracke
RATIONALE: B cell-activating factor (BAFF) plays a major role in activation of B cells and in adaptive humoral immune responses. In chronic obstructive pulmonary disease (COPD), lymphoid follicles have been associated with disease severity, and overexpression of BAFF has been demonstrated within lymphoid follicles of patients with severe COPD. OBJECTIVES: To investigate expression and localization of BAFF in the lungs of patients with COPD and to study the role of BAFF in COPD by antagonizing BAFF in a mouse model of chronic cigarette smoke (CS) exposure...
September 15, 2015: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26254421/in-vivo-compartmental-analysis-of-leukocytes-in-mouse-lungs
#18
Brijesh V Patel, Kate C Tatham, Michael R Wilson, Kieran P O'Dea, Masao Takata
The lung has a unique structure consisting of three functionally different compartments (alveolar, interstitial, and vascular) situated in an extreme proximity. Current methods to localize lung leukocytes using bronchoalveolar lavage and/or lung perfusion have significant limitations for determination of location and phenotype of leukocytes. Here we present a novel method using in vivo antibody labeling to enable accurate compartmental localization/quantification and phenotyping of mouse lung leukocytes. Anesthetized C57BL/6 mice received combined in vivo intravenous and intratracheal labeling with fluorophore-conjugated anti-CD45 antibodies, and lung single-cell suspensions were analyzed by flow cytometry...
October 1, 2015: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/26231702/pleiotropic-effect-of-the-proton-pump-inhibitor-esomeprazole-leading-to-suppression-of-lung-inflammation-and-fibrosis
#19
Yohannes T Ghebremariam, John P Cooke, William Gerhart, Carol Griego, Jeremy B Brower, Melanie Doyle-Eisele, Benjamin C Moeller, Qingtao Zhou, Lawrence Ho, Joao de Andrade, Ganesh Raghu, Leif Peterson, Andreana Rivera, Glenn D Rosen
BACKGROUND: The beneficial outcome associated with the use of proton pump inhibitors (PPIs) in idiopathic pulmonary fibrosis (IPF) has been reported in retrospective studies. To date, no prospective study has been conducted to confirm these outcomes. In addition, the potential mechanism by which PPIs improve measures of lung function and/or transplant-free survival in IPF has not been elucidated. METHODS: Here, we used biochemical, cell biological and preclinical studies to evaluate regulation of markers associated with inflammation and fibrosis...
2015: Journal of Translational Medicine
https://www.readbyqxmd.com/read/26231396/building-a-better-neonatal-mouse-model-to-understand-infant-respiratory-syncytial-virus-disease
#20
Dahui You, David T Siefker, Bishwas Shrestha, Jordy Saravia, Stephania A Cormier
BACKGROUND: Respiratory syncytial virus (RSV) is the number one cause of lower respiratory tract infection in infants; and severe RSV infection in infants is associated with asthma development. Today, there are still no vaccines or specific antiviral therapies against RSV. The mechanisms of RSV pathogenesis in infants remain elusive. This is partly due to the fact that the largely-used mouse model is semi-permissive for RSV. The present study sought to determine if a better neonatal mouse model of RSV infection could be obtained using a chimeric virus in which the F protein of A2 strain was replaced with the F protein from the line 19 clinical isolate (rA2-19F)...
2015: Respiratory Research
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