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Subclinical disease

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https://www.readbyqxmd.com/read/29218278/evaluation-of-subclinical-extension-of-basal-cell-carcinoma
#1
Arash Beiraghi Toosi, Nema Mohamadian Roshan, Mahdi Ghoncheh
BACKGROUND: Basal cell carcinoma (BCC) is the most common malignancy with increasing incidence worldwide. The tumor invades surrounding tissues in an irregular pattern via subclinical and microscopic finger-like growths known as subclinical extension. Subclinical extension may be responsible for incomplete resection of the tumor. This study investigates the subclinical extension of BCC. METHODS: In a retrospective study for evaluation of subclinical extension of BCC, Patients' demographic data and characteristics (disease duration, location, size, and history of radiotherapy) were documented...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29217611/air-pollution-and-subclinical-interstitial-lung-disease-the-multi-ethnic-study-of-atherosclerosis-mesa-air-lung-study
#2
Coralynn Sack, Sverre Vedal, Lianne Sheppard, Ganesh Raghu, R Graham Barr, Anna Podolanczuk, Brent Doney, Eric A Hoffman, Amanda Gassett, Karen Hinckley-Stukovsky, Kayleen Williams, Steve Kawut, David J Lederer, Joel D Kaufman
We studied whether ambient air pollution is associated with interstitial lung abnormalities (ILAs) and high attenuation areas (HAAs), which are qualitative and quantitative measurements of subclinical interstitial lung disease (ILD) on computed tomography (CT).We performed analyses of community-based dwellers enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) study. We used cohort-specific spatio-temporal models to estimate ambient pollution (fine particulate matter (PM2.5), nitrogen oxides (NOx), nitrogen dioxide (NO2) and ozone (O3)) at each home...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29217327/changes-of-adenosinergic-system-in-piglets-fed-a-diet-co-contaminated-by-mycotoxin-and-its-effects-on-the-regulation-of-adenosine
#3
Carine F Souza, Aleksandro S Da Silva, Lucieli K F Müller, Matheus D Baldissera, Nathieli B Bottari, Maria Rosa C Schetinger, Janio M Santurio, Eduardo M Gloria, Gustavo Machado, Régis A Zanette, Diovani Paiano
The effects of diets co-contaminated with 300 μg/kg of aflatoxins and 8000 μg/kg of fumonisins on adenosinergic system of the pigs weaned at 15 days of age were studied. Piglets were inspected daily, and body weight measurement and blood collections were performed at every five days. Piglets intoxicated by mycotoxins presented lower weight gain (p < 0.001) in comparison to control. Intoxicated piglets also showed a reduction in the serum levels of zinc and adenosine and in adenosine deaminase (ADA) activity (p < 0...
December 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29216794/fragmented-qrs-complexes-are-associated-with-left-ventricular-dysfunction-in-patients-with-type-2-diabetes-mellitus-a-two-dimensional-speckle-tracking-echocardiography-study
#4
Adil Bayramoğlu, Hakan Taşolar, Yasemin Kaya, Osman Bektaş, Ahmet Kaya, Mehmet Yaman, Zeki Yüksel Günaydın
BACKGROUND: Heart failure may develop independently of coronary artery disease in diabetes mellitus (DM) patients. Fragmented QRS (fQRS) is a marker of myocardial fibrosis or scar tissue and is related to an increase in cardiovascular adverse events. In this study, we examined the utility of speckle tracking echocardiography (STE) in assessing LV function in DM patients with fQRS. METHODS AND RESULTS: The current study included 178 consecutive patients diagnosed with type-2 DM...
December 7, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29216423/nanoparticle-functionalization-with-platelet-membrane-enables-multi-factored-biological-targeting-and-detection-of-atherosclerosis
#5
Xiaoli Wei, Man Ying, Diana Dehaini, Yuanyuan Su, Ashley V Kroll, Jiarong Zhou, Weiwei Gao, Ronnie H Fang, Shu Chien, Liangfang Zhang
Cardiovascular disease represents one of the major causes of death across the global population. Atherosclerosis, one of its most common drivers, is characterized by the gradual build-up of arterial plaque over time, which can ultimately lead to life-threatening conditions. Given the impact of the disease on public health, there is a great need for effective and noninvasive imaging modalities that can provide valuable information on its biological underpinnings during development. Here, we leverage the role of platelets in atherogenesis to design nanocarriers capable of targeting multiple biological elements relevant to plaque development...
December 7, 2017: ACS Nano
https://www.readbyqxmd.com/read/29212987/association-of-coronary-artery-calcification-with-estimated-coronary-heart-disease-risk-from-prediction-models-in-a-community-based-sample-of-japanese-men-the-shiga-epidemiological-study-of-subclinical-atherosclerosis-sessa
#6
Akira Fujiyoshi, Hisatomi Arima, Sachiko Tanaka-Mizuno, Takahashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Akira Sekikawa, Takashi Yamamoto, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima
AIM: The clinical significance of coronary artery calcification (CAC) is not fully determined in general East Asian populations where background coronary heart disease (CHD) is less common than in USA/Western countries. We cross-sectionally assessed the association between CAC and estimated CHD risk as well as each major risk factor in general Japanese men. METHODS: Participants were 996 randomly selected Japanese men aged 40-79 y, free of stroke, myocardial infarction, or revascularization...
December 5, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29210349/high-prevalence-of-shigella-or-enteroinvasive-escherichia-coli-carriage-among-residents-of-an-internally-displaced-persons-camp-in-south-sudan
#7
Jesse Bliss, Malika Bouhenia, Peter Hale, Brianne A Couturier, Anita S Iyer, John Rumunu, Stephen Martin, Joseph F Wamala, Abdinasir Abubakar, David A Sack, Francisco J Luquero, Marc Roger Couturier, Andrew S Azman, Daniel T Leung
Displaced persons living in camps are at an increased risk of diarrheal diseases. Subclinical carriage of pathogens may contribute to the spread of disease, especially for microbes that require a low infectious dose. Multiplex real-time polymerase chain reaction was performed to detect a panel of 20 bacterial, viral, and protozoal targets, and we report a high prevalence of enteropathogen carriage, including Shigella spp. or enteroinvasive Escherichia coli in 14%, among a sample of 88 asymptomatic individuals in an internally displaced persons camp in South Sudan...
December 4, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29210085/subclinical-systolic-and-diastolic-dysfunctions-in-patients-with-metabolic-syndrome-and-angiographically-normal-coronary-arteries-an-echocardiographic-study
#8
Niloufar Samiei, Maryam Bayat, Ata Firouzi, Faezeh Dehghani, Mozhgan Parsaee, Shahin Rahimi, Somayyeh Ahmadi, Maryam Pourmojib, Zahra Ghaemmaghami, Yousef Rezaei, Mohammad Mehdi Peighambari
BACKGROUND: The metabolic syndrome (MetS), as a combination of cardiovascular risk factors, is associated with subclinical cardiovascular diseases. We sought to evaluate the subclinical myocardial dysfunctions using echocardiography in patients with normal coronary arteries. MATERIALS AND METHODS: In this cross-sectional study, we assessed 50 consecutive patients with angiographically-proven normal coronary arteries and a left ventricular (LV) ejection fraction (EF) ≥55%...
December 6, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29209636/neurofilament-light-chain-predicts-disease-activity-in-relapsing-remitting-ms
#9
Kristin N Varhaug, Christian Barro, Kjetil Bjørnevik, Kjell-Morten Myhr, Øivind Torkildsen, Stig Wergeland, Laurence A Bindoff, Jens Kuhle, Christian Vedeler
Objective: To investigate whether serum neurofilament light chain (NF-L) and chitinase 3-like 1 (CHI3L1) predict disease activity in relapsing-remitting MS (RRMS). Methods: A cohort of 85 patients with RRMS were followed for 2 years (6 months without disease-modifying treatment and 18 months with interferon-beta 1a [IFNB-1a]). Expanded Disability Status Scale was scored at baseline and every 6 months thereafter. MRI was performed at baseline and monthly for 9 months and then at months 12 and 24...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29206233/genome-wide-admixture-and-association-study-of-subclinical-atherosclerosis-in-the-women-s-interagency-hiv-study-wihs
#10
Aditi Shendre, Howard W Wiener, Marguerite R Irvin, Bradley E Aouizerat, Edgar T Overton, Jason Lazar, Chenglong Liu, Howard N Hodis, Nita A Limdi, Kathleen M Weber, Stephen J Gange, Degui Zhi, Michelle A Floris-Moore, Ighovwerha Ofotokun, Qibin Qi, David B Hanna, Robert C Kaplan, Sadeep Shrestha
Cardiovascular disease (CVD) is a major comorbidity among HIV-infected individuals. Common carotid artery intima-media thickness (cCIMT) is a valid and reliable subclinical measure of atherosclerosis and is known to predict CVD. We performed genome-wide association (GWA) and admixture analysis among 682 HIV-positive and 288 HIV-negative Black, non-Hispanic women from the Women's Interagency HIV study (WIHS) cohort using a combined and stratified analysis approach. We found some suggestive associations but none of the SNPs reached genome-wide statistical significance in our GWAS analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29205858/foot-and-mouth-disease-virus-transmission-dynamics-and-persistence-in-a-herd-of-vaccinated-dairy-cattle-in-india
#11
S S Hayer, K VanderWaal, R Ranjan, J K Biswal, S Subramaniam, J K Mohapatra, G K Sharma, M Rout, B B Dash, B Das, B R Prusty, A K Sharma, C Stenfeldt, A Perez, A H Delgado, M K Sharma, L L Rodriguez, B Pattnaik, J Arzt
Foot-and-mouth disease (FMD) is an important transboundary disease with substantial economic impacts. Although between-herd transmission of the disease has been well studied, studies focusing on within-herd transmission using farm-level outbreak data are rare. The aim of this study was to estimate parameters associated with within-herd transmission, host physiological factors and FMD virus (FMDV) persistence using data collected from an outbreak that occurred at a large, organized dairy farm in India. Of 1,836 regularly vaccinated, adult dairy cattle, 222 had clinical signs of FMD over a 39-day period...
December 5, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29205484/subclinical-left-ventricular-systolic-and-diastolic-dysfunction-in-type-1-diabetic-children-and-adolescents-with-good-metabolic-control
#12
Tamer Yoldaş, Utku Arman Örün, Elif Sagsak, Zehra Aycan, Özkan Kaya, Senem Özgür, Selmin Karademir
OBJECTIVE: Cardiac dysfunction is a well-known consequence of diabetes mellitus. This study was designed to assess whether type 1 diabetic children and adolescents with good metabolic control have early echocardiographic signs of subclinical left ventricular dysfunction and whether diabetes duration has any influence, using conventional and nonconventional echocardiographic tools. METHODS: A total of 100 patients with type 1 diabetes mellitus and 80 gender- and age-matched healthy controls were included...
December 3, 2017: Echocardiography
https://www.readbyqxmd.com/read/29204762/magnetic-resonance-imaging-mri-of-feet-demonstrates-subclinical-inflammatory-joint-disease-in-cutaneous-psoriasis-patients-without-clinical-arthritis
#13
Ashish J Mathew, Paul Bird, Ankan Gupta, Renu George, Debashish Danda
We evaluated inflammation at the small joints of feet in psoriasis patients without clinical arthritis (PsO) as against clinically overt psoriatic arthritis (PsA) patients, using a low field magnet extremity MRI (eMRI). Patients with psoriasis recruited from dermatology and rheumatology clinics of a tertiary care institution in southern India were divided into PsO and PsA groups. Demographic and physical examination details were recorded. Consenting patients underwent non-contrast eMRI of the right foot. Two trained readers scored the MRI parameters of inflammation (synovitis, tenosynovitis, osteitis) using a modification of the PsA magnetic resonance imaging score (PsAMRIS)...
December 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29204234/carotid-doppler-ultrasonography-as-a-screening-tool-of-early-atherosclerotic-changes-in-children-and-young-adults-with-%C3%AE-thalassemia-major
#14
Seif El-Din Abaza, Amina Abdel-Salam, Ahmed A Baz, Amira A Mohamed
Purpose: β-thalassemia major (β-TM) patients had an increased incidence of cardiovascular complications secondary to iron overload. They showed early carotid atherosclerosis as showed by increased carotid intima media thickness (CIMT) that may occur early even when significant iron overload is absent. We aimed to test the diagnostic performance of CIMT measurement by Doppler ultrasonography as a structural indicator for premature atherosclerosis in β-TM patients. Methods: Case-control study included 42 β-TM patients (24 males and 18 females) aged from 3 to 30 years and 36 age- and sex-matched healthy controls...
December 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/29203050/integrins-integrating-the-biology-and-therapy-of-cell-cell-interactions
#15
REVIEW
Franco Pandolfi, Laura Franza, Simona Altamura, Claudia Mandolini, Cianci Rossella, Aftab Ansari, James T Kurnick
PURPOSE: Although the role of integrins has been described in a variety of diseases, these roles seem to be distinct. To date, no study has attempted to provide links to the various pathways by which such integrins can be involved in these diverse disease settings. The purpose of this review was to address this gap in our knowledge with the hypothesis that there is, in fact, a common pathway by which integrins may function. METHODS: This article provides an in-depth perspective on the discovery, development, and design of therapeutics that modulate cellular function by targeting integrin:ligand interactions by reviewing the literature on this subject; the review included the most recent results of clinical and subclinical studies...
December 1, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29202828/calculation-of-the-disease-burden-associated-with-environmental-chemical-exposures-application-of-toxicological-information-in-health-economic-estimation
#16
REVIEW
Philippe Grandjean, Martine Bellanger
Calculation of costs and the Burden of Disease (BoD) is useful in developing resource allocation and prioritization strategies in public and environmental health. While useful, the Disability-Adjusted Life Year (DALY) metric disregards subclinical dysfunctions, adheres to stringent causal criteria, and is hampered by gaps in environmental exposure data, especially from industrializing countries. For these reasons, a recently calculated environmental BoD of 5.18% of the total DALYs is likely underestimated. We combined and extended cost calculations for exposures to environmental chemicals, including neurotoxicants, air pollution, and endocrine disrupting chemicals, where sufficient data were available to determine dose-dependent adverse effects...
December 5, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29201159/cardiovascular-risks-in-chronic-kidney-disease-pediatric-patients
#17
Jing Tian, Ling Niu, Xinjiang An
One of the common factors for the premature death in children is advanced chronic kidney disease (CKD). Most often cardiovascular disease (CVD) is the reason for mortality. The cardiovascular (CV) morbidity starts early in the disease process and renal transplanted children (CKD-T) are also at risk. The present review is focused on the current views of the cardiovascular risks during CKD in pediatric patients. Variable data sources for the latest literature collection were explored which mainly included PubMed and Google Scholar...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29201071/hemostasis-in-overt-and-subclinical-hyperthyroidism
#18
REVIEW
Arash Ordookhani, Kenneth D Burman
Context: There are contradictory results on the effect of hyperthyroidism on hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). The present review focuses on hemostatic changes in overt and subclinical hyperthyroidism. Methods: A systematic literature search was conducted employing MEDLINE database. The following words were used for the search: Hyperthyroidism; thyrotoxicosis; Graves disease; goiter, nodular; hemostasis; blood coagulation factors; blood coagulation disorders; venous thromboembolism; bleeding; fibrinolysis...
July 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29200023/large-arteries-dysfunction-in-primary-antiphospholipid-syndrome
#19
Gilmar S Osmundo, Jozélio Freire Carvalho, Luiz A Bortolotto, Vilma S T Viana, Eloisa Bonfá
OBJECTIVE: The aim of this study was to assess the arterial distensibility of large vessels and changes in microvasculature in primary antiphospholipid syndrome. METHODS: Twenty-two antiphospholipid syndrome patients and 66 age-, sex-, height-, and blood pressure-matched control subjects were included in the study. Second derivative of the finger photoplethysmogram (SDPTG) has been used as a noninvasive method to evaluate the pulse wave. The b/a and d/a indices, which reflect, respectively, large-vessel and small-vessel properties, were calculated from the SDPTG waveform components...
December 1, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29198886/remaining-localsubclinical-joint-inflammation-is-associated-with-deteriorated-metacarpeal-head-bone-microarchitecture-in-rheumatoid-arthritis-patients-low-disease-activity
#20
Shuing Kong, Hervé Locrelle, Adamah Amouzougan, Delphine Denarie, Philippe Collet, Béatrice Pallot Prades, Thierry Thomas, Hubert Marotte
OBJECTIVES: Bone alterations at the subchondral level during rheumatoid arthritis (RA) remain under investigation. It remains unknown whether subchondral bone damage might still occur in RA patients in clinical remission, which could then infer suggesting that even minor subclinical inflammatory changes in the joint can induce local bone loss. METHODS: Thirty-two RA patients treated with biological disease-modifying anti-rheumatic drugs (bDMARDs) with low disease activity since at least 6 months and having erosion on the second or third metacarpeal head were enrolled in this pilot cross-sectional study...
November 30, 2017: Joint, Bone, Spine: Revue du Rhumatisme
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