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JOURNAL ARTICLE
Patricia B Pavlinac, James Platts-Mills, Jie Liu, Hannah E Atlas, Jean Gratz, Darwin Operario, Elizabeth Rogawski McQuade, Dilruba Ahmed, Tahmeed Ahmed, Tahmina Alam, Per Ashorn, Henry Badji, Rajiv Bahl, Naor Bar-Zeev, Mohammod Jobayer Chisti, Jen Cornick, Aishwarya Chauhan, Ayesha De Costa, Saikat Deb, Usha Dhingra, Queen Dube, Christopher P Duggan, Bridget Freyne, Wilson Gumbi, Aneeta Hotwani, Mamun Kabir, Ohedul Islam, Furqan Kabir, Irene Kasumba, Upendo Kibwana, Karen L Kotloff, Shaila S Khan, Victor Maiden, Karim Manji, Ashka Mehta, Latif Ndeketa, Ira Praharaj, Farah Naz Qamar, Sunil Sazawal, Jonathon Simon, Benson O Singa, Sarah Somji, Samba O Sow, Milagritos D Tapia, Caroline Tigoi, Aliou Toure, Judd L Walson, Mohammad Tahir Yousafzai, Eric R Houpt
BACKGROUND: Bacterial pathogens cause substantial diarrhea morbidity and mortality among children living in endemic settings, yet antimicrobial treatment is only recommended for dysentery or suspected cholera. METHODS: AntiBiotics for Children with severe Diarrhea was a 7-country placebo-controlled double-blind efficacy trial of azithromycin in children 2-23 months of age with watery diarrhea accompanied by dehydration or malnutrition. We tested fecal samples for enteric pathogens utilizing quantitative PCR and employed pathogen-specific cutoffs based on genomic target quantity in previous case control diarrhea etiology studies to identify likely and possible bacterial etiologies...
July 5, 2023: Journal of Infectious Diseases
#22
JOURNAL ARTICLE
Alex P Miller, David A A Baranger, Sarah E Paul, Alexander S Hatoum, Cynthia Rogers, Ryan Bogdan, Arpana Agrawal
No abstract text is available yet for this article.
June 26, 2023: JAMA Pediatrics
#23
JOURNAL ARTICLE
Jason M Nagata, Sana Alsamman, Natalia Smith, Jiayue Yu, Kyle T Ganson, Erin E Dooley, David Wing, Fiona C Baker, Kelley Pettee Gabriel
BACKGROUND: Sociodemographic disparities in adolescent physical activity have been documented but mostly rely on self-reported data. Our objective was to examine differences in device-based step metrics, including daily step count (steps d-1 ), by sociodemographic factors among a diverse sample of 10-to-14-year-old adolescents in the US. METHODS: We analyzed prospective cohort data from Year 2 (2018-2020) of the Adolescent Brain Cognitive Development (ABCD) Study (N = 6460)...
June 23, 2023: Pediatric Research
#24
REVIEW
G Szummer, S Wutzler
Severe multiple trauma in children is rare with approximately 380-550 cases per year in Germany. In addition to the S3 guideline "Polytrauma", which was published more than a decade ago, the S2K guideline "Severe multiple trauma care in childhood" was published in 2020. Accidents and especially the resulting traumatic brain injuries still represent the most frequent cause of death in children. While prehospital treatment according to Prehospital Trauma Life Support (PHTLS®) is basically analogous to that in adults which is based on the ABCDE concept (airway, breathing, circulation, disability, exposure), knowledge of age-dependent anatomical-physiological characteristics is essential...
June 21, 2023: Medizinische Klinik, Intensivmedizin und Notfallmedizin
#25
JOURNAL ARTICLE
Jason M Nagata, Joanne Yang, Sana Alsamman, Abubakr A A Al-Shoaibi, Kyle T Ganson, Kelley Pettee Gabriel, Fiona C Baker
The COVID-19 pandemic led to significant disruptions in the lifestyle behaviors of adolescents; however, there is a paucity of data on objective changes in health indicators of adolescents such as blood pressure, hypertension, and weight. The aim of this study is to quantify differences in blood pressure and weight before and during the COVID-19 pandemic among a demographically diverse national sample of early adolescents. We analyzed cross-sectional data from 2018 to 2020, corresponding to the second follow-up year (Year 2) of the Adolescent Brain Cognitive Development (ABCD) Study...
June 2023: American journal of preventive cardiology
#26
JOURNAL ARTICLE
Monika A Waszczuk, Jiaju Miao, Anna R Docherty, Andrey A Shabalin, Katherine G Jonas, Giorgia Michelini, Roman Kotov
BACKGROUND: Polygenic risk scores (PRSs) capture genetic vulnerability to psychiatric conditions. However, PRSs are often associated with multiple mental health problems in children, complicating their use in research and clinical practice. The current study is the first to systematically test which PRSs associate broadly with all forms of childhood psychopathology, and which PRSs are more specific to one or a handful of forms of psychopathology. METHODS: The sample consisted of 4717 unrelated children (mean age = 9...
April 2023: Psychological Medicine
#27
Rachel Gross, Tanayott Thaweethai, Erika B Rosenzweig, James Chan, Lori B Chibnik, Mine S Cicek, Amy J Elliott, Valerie J Flaherman, Andrea S Foulkes, Margot Gage Witvliet, Richard Gallagher, Maria Laura Gennaro, Terry L Jernigan, Elizabeth W Karlson, Stuart D Katz, Patricia A Kinser, Lawrence C Kleinman, Michelle F Lamendola-Essel, Joshua D Milner, Sindhu Mohandas, Praveen C Mudumbi, Jane W Newburger, Kyung E Rhee, Amy L Salisbury, Jessica N Snowden, Cheryl R Stein, Melissa S Stockwell, Kelan G Tantisira, Moriah E Thomason, Dongngan T Truong, David Warburton, John C Wood, Shifa Ahmed, Almary Akerlundh, Akram N Alshawabkeh, Brett R Anderson, Judy L Aschner, Andrew M Atz, Robin L Aupperle, Fiona C Baker, Venkataraman Balaraman, Dithi Banerjee, Deanna M Barch, Arielle Baskin-Sommers, Sultana Bhuiyan, Marie-Abele C Bind, Amanda L Bogie, Natalie C Buchbinder, Elliott Bueler, Hülya Bükülmez, B J Casey, Linda Chang, Duncan B Clark, Rebecca G Clifton, Katharine N Clouser, Lesley Cottrell, Kelly Cowan, Viren D'Sa, Mirella Dapretto, Soham Dasgupta, Walter Dehority, Kirsten B Dummer, Matthew D Elias, Shari Esquenazi-Karonika, Danielle N Evans, E Vincent S Faustino, Alexander G Fiks, Daniel Forsha, John J Foxe, Naomi P Friedman, Greta Fry, Sunanda Gaur, Dylan G Gee, Kevin M Gray, Ashraf S Harahsheh, Andrew C Heath, Mary M Heitzeg, Christina M Hester, Sophia Hill, Laura Hobart-Porter, Travis K F Hong, Carol R Horowitz, Daniel S Hsia, Matthew Huentelman, Kathy D Hummel, William G Iacono, Katherine Irby, Joanna Jacobus, Vanessa L Jacoby, Pei-Ni Jone, David C Kaelber, Tyler J Kasmarcak, Matthew J Kluko, Jessica S Kosut, Angela R Laird, Jeremy Landeo-Gutierrez, Sean M Lang, Christine L Larson, Peter Paul C Lim, Krista M Lisdahl, Brian W McCrindle, Russell J McCulloh, Alan L Mendelsohn, Torri D Metz, Lerraughn M Morgan, Eva M Müller-Oehring, Erica R Nahin, Michael C Neale, Manette Ness-Cochinwala, Sheila M Nolan, Carlos R Oliveira, Matthew E Oster, R Mark Payne, Hengameh Raissy, Isabelle G Randall, Suchitra Rao, Harrison T Reeder, Johana M Rosas, Mark W Russell, Arash A Sabati, Yamuna Sanil, Alice I Sato, Michael S Schechter, Rangaraj Selvarangan, Divya Shakti, Kavita Sharma, Lindsay M Squeglia, Michelle D Stevenson, Jacqueline Szmuszkovicz, Maria M Talavera-Barber, Ronald J Teufel, Deepika Thacker, Mmekom M Udosen, Megan R Warner, Sara E Watson, Alan Werzberger, Jordan C Weyer, Marion J Wood, H Shonna Yin, William T Zempsky, Emily Zimmerman, Benard P Dreyer
IMPORTANCE: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults. OBSERVATIONS: We describe the protocol for the Pediatric Observational Cohort Study of the NIH's RE searching COV ID to E nhance R ecovery (RECOVER) Initiative...
May 12, 2023: medRxiv
#28
JOURNAL ARTICLE
David F Montez, Andrew N Van, Ryland L Miller, Nicole A Seider, Scott Marek, Annie Zheng, Dillan J Newbold, Kristen Scheidter, Eric Feczko, Anders J Perrone, Oscar Miranda-Dominguez, Eric A Earl, Benjamin P Kay, Abhinav K Jha, Aristeidis Sotiras, Timothy O Laumann, Deanna J Greene, Evan M Gordon, M Dylan Tisdall, Andre van der Kouwe, Damien A Fair, Nico U F Dosenbach
Functional MRI (fMRI) data acquired using echo-planar imaging (EPI) are highly distorted by magnetic field inhomogeneities. Distortion and differences in image contrast between EPI and T1-weighted and T2-weighted (T1w/T2w) images makes their alignment a challenge. Typically, field map data are used to correct EPI distortions. Alignments achieved with field maps can vary greatly and depends on the quality of field map data. However, many public datasets lack field map data entirely. Additionally, reliable field map data is often difficult to acquire in high-motion pediatric or developmental cohorts...
March 24, 2023: Developmental Cognitive Neuroscience
#29
JOURNAL ARTICLE
Vincenzo De Giorgi, Elisabetta Magnaterra, Biancamaria Zuccaro, Serena Magi, Manfredi Magliulo, Matelda Medri, Laura Mazzoni, Federico Venturi, Flavia Silvestri, Gian Marco Tomassini, Massimo Gola, Marta Tramontana, Samantha Berti, Ignazio Stanganelli, Luca Stingeni, Piero Covarelli
PURPOSE: To improve the diagnostic accuracy and optimal management of pediatric melanomas. METHODS: We conducted a retrospective descriptive, multicenter study of the epidemiological, clinical, and dermoscopic characteristics of histopathologically proven melanomas diagnosed in patients less than 18 years old. Data on sociodemographic variables, clinical and dermoscopic characteristics, histopathology, local extension, therapy and follow-up, lymph node staging, and outcome were collected from the databases of three Italian dermatology units...
March 18, 2023: Cancers
#30
JOURNAL ARTICLE
Hannah Loso, Bader Chaarani, Sarahjane Locke Dube, Matthew D Albaugh, Aya Cheaito, Hugh Garavan, Alexandra Potter
INTRODUCTION: Stressful childhood experiences are associated with unique brain activity patterns during emotional processing. Specifically, pediatric stress is linked to activation in the insulae, superior temporal and parahippocampal gyri, and the amygdalae, as well as differential activation in the dorsal anterior cingulate cortex when viewing emotional faces. Gender diversity is broadly associated with higher victimization and mental health disparities in children aged 9/10, but whether it is associated with stress-like alterations in brain function (BOLD signal during task-based fMRI) remains unknown...
2023: Frontiers in Integrative Neuroscience
#31
JOURNAL ARTICLE
Gyula Tövisházi, Katalin Csordás, Balázs Hauser
Our aim is to summarize the new European Resuscitation Council (ERC) 2021 guidelines on paediatric life support. In children, exhaustion of compensatory mechanisms in respiratory or circulatory failure leads to cardiac arrest. Recognition and treatment of children in critical condition are the most important element of its prevention. With the ABCDE approach, life-threatening problems can be identified and treated using simple interventions (bag-mask ventilation, intraosseous access, fluid bolus, etc.). Important new recommendations: 4-hand ventilation during bag-mask ventilation, target saturation of 94-98% during oxygen therapy, and fluid bolus of 10 ml/kg...
March 26, 2023: Orvosi Hetilap
#32
JOURNAL ARTICLE
Fanny Dégeilh, Tilmann von Soest, Lia Ferschmann, Joanne C Beer, Malo Gaubert, Inga K Koerte, Christian K Tamnes
Childhood mild traumatic brain injury (mTBI) is associated with elevated risk of developing social problems, which may be underpinned by changes in the structural developmental trajectory of the social brain, a network of cortical regions supporting social cognition and behavior. However, limited sample sizes and cross-sectional designs generally used in neuroimaging studies of pediatric TBI have prevented explorations of this hypothesis. This longitudinal retrospective study examined the development of parent-reported social problems and cortical thickness in social brain regions following childhood mTBI using data from the large population-based Adolescent Brain Cognitive Development (ABCD) Study...
February 27, 2023: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
#33
REVIEW
Márcia Alessandra Cavalaro Pereira da Silva, Márcio Lopes Miranda, António Gonçalves Oliveira-Filho, Joaquim Murray Bustorff-Silva
BACKGROUND: Bishop-Koop ileostomy has been widely used in pediatric patients with the intention of including as much bowel as possible in the intestinal transit early in the management of children with meconium ileus and intestinal atresia. In recent years, we have been using it as an alternative to test the distal bowel function before closure of a previously constructed ostomy in selected children with questionable distal bowel motility. AIMS: The aim of this study was to present our experience with this alternative use of the Bishop-Koop ostomy...
2023: Brazilian Archives of Digestive Surgery: ABCD
#34
Hajer Nakua, Ju-Chi Yu, Herv Abdi, Colin Hawco, Aristotle Voineskos, Sean Hill, Meng-Chuan Lai, Anne L Wheeler, Anthony Randal McIntosh, Stephanie H Ameis
INTRODUCTION: Canonical Correlation Analysis (CCA) and Partial Least Squares Correlation (PLS) detect associations between two data matrices based on computing a linear combination between the two matrices (called latent variables; LVs). These LVs maximize correlation (CCA) and covariance (PLS). These different maximization criteria may render one approach more stable and reproducible than the other when working with brain and behavioural data at the population-level. This study compared the LVs which emerged from CCA and PLS analyses of brain-behaviour relationships from the Adolescent Brain Cognitive Development (ABCD) dataset and examined their stability and reproducibility...
March 9, 2023: bioRxiv
#35
JOURNAL ARTICLE
Jason M Nagata, Natalia Smith, Omar M Sajjad, Gabriel Zamora, Julia H Raney, Kyle T Ganson, Alexander Testa, Eric Vittinghoff, Dylan B Jackson
The objective of this study was to explore the relationship between accumulating adverse childhood experiences (ACEs) and sipping alcohol in a large, nationwide sample of 9-to-10-year-old U.S. children. We analyzed data from the Adolescent Brain Cognitive Development (ABCD) Study (2016-2018). Of 10,853 children (49.1 % female), 23.4 % reported ever sipping alcohol. A greater ACE score was associated with a higher risk of sipping alcohol. Having 4 or more ACEs placed children at 1.27 times the risk (95 % CI 1...
April 2023: Preventive Medicine Reports
#36
JOURNAL ARTICLE
Jefferson de Souza Dias, Ricardo Ribeiro Agostinete, Jacqueline Bexiga Urban, Wésley Torres, Eduardo Duarte de Lima Mesquita, Suziane Ungari Cayres-Santos, Lucas Gabriel de Moraes Chagas, Ítalo Ribeiro Lemes, Rômulo Araújo Fernandes
OBJECTIVE: To analyze the relationship between resistance training and body composition in adolescents. METHODS: A longitudinal 12-month follow up of 190 adolescents of both sexes categorized into three groups according to resistance training practice, as non-engagement (n=121), irregular engagement (n=44), and frequent engagement (n=25). The outcomes adopted were bone mineral density (BMD), lean soft tissue (LST), and body fatness (BF). RESULTS: Adolescents frequently engaged in resistance training presented higher gains in mean (95 CI) LST [6...
April 15, 2023: Indian Pediatrics
#37
JOURNAL ARTICLE
Ana Elisa von Ah Morano, Wésley Torres, Eduardo Zancheti, Andrea Wigna Pereira de Jesus, Jacqueline Bexiga Urban, Romulo Araújo Fernandes
BACKGROUND: To investigate the combined impact of being engaged in resistance training (RT) and meeting the physical activity guidelines through sports participation (SP) on cardiovascular and metabolic parameters in lean adolescents. METHODS: A longitudinal study, part of the ongoing study entitled "ABCD Growth Study" (Analysis of Behaviors of Children During Growth), assessed data from 64 adolescents (23 from the sport group, 11 from the sport + RT group, and 30 from the control group)...
December 27, 2022: International Journal of Environmental Research and Public Health
#38
JOURNAL ARTICLE
Jason M Nagata, Joanne H Yang, Gurbinder Singh, Orsolya Kiss, Kyle T Ganson, Alexander Testa, Dylan B Jackson, Fiona C Baker
OBJECTIVE: To determine the association between cyberbullying (victimization and perpetration) and sleep disturbance among a demographically diverse sample of 10-14-year-old early adolescents. METHODS: We analyzed cross-sectional data from the Adolescent Brain Cognitive Development (ABCD) Study (Year 2, 2018-2020) of early adolescents (10-14 years) in the U.S. Modified Poisson regression analyses examined the association between cyberbullying and self-reported and caregiver-reported sleep disturbance measures...
December 26, 2022: Academic Pediatrics
#39
JOURNAL ARTICLE
Associations between socioeconomic gradients and racial disparities in preadolescent brain outcomes.
Amal Isaiah, Thomas M Ernst, HuaJun Liang, Meghann Ryan, Eric Cunningham, Pedro J Rodriguez, Miriam Menken, Dianne Kaschak, Ciara Guihen, Gloria Reeves, Nancy Lever, Sarah M Edwards, Linda Chang
BACKGROUND: The aim of this study was to determine the extent to which socioeconomic characteristics of the home and neighborhood are associated with racial inequalities in brain outcomes. METHODS: We performed a cross-sectional analysis of the baseline dataset (v.2.0.1) from the Adolescent Brain and Cognitive Development (ABCD) Study. Cognitive performance was assessed using the National Institutes of Health Toolbox (NIH-TB) cognitive battery. Standard socioeconomic indicators of the family and neighborhood were derived from census-related statistics...
December 1, 2022: Pediatric Research
#40
JOURNAL ARTICLE
Jason M Nagata, Nora Trompeter, Gurbinder Singh, Julia Raney, Kyle T Ganson, Alexander Testa, Dylan B Jackson, Stuart B Murray, Fiona C Baker
INTRODUCTION: With the increasing use of social media and online platforms among adolescents, the relationship between traumatic life events and cyberbullying remains unclear. This study aimed to determine the associations between adverse childhood experiences (ACEs) and cyberbullying victimization among a racially/ethnically and socioeconomically diverse sample of early adolescents. METHODS: We analyzed longitudinal data from 10,317 participants in the Adolescent Brain Cognitive Development (ABCD) study, baseline (2016-2018, ages 9-10 years) to Year 2...
November 28, 2022: Journal of Adolescence
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