Lara M Gomes, Milena Carvalho-Silva, Letícia J Teixeira, Joyce Rebelo, Isabella T Mota, Rafaela Bilesimo, Monique Michels, Camila O Arent, Edemilson Mariot, Felipe Dal-Pizzol, Giselli Scaini, João Quevedo, Emilio L Streck
Studies have shown that oxidative stress is involved in the pathophysiology of bipolar disorder (BD). It is suggested that omega-3 (ω3) fatty acids are fundamental to maintaining the functional integrity of the central nervous system. The animal model used in this study displayed fenproporex-induced hyperactivity, a symptom similar to manic BD. Our results showed that the administration of fenproporex, in the prevent treatment protocol, increased lipid peroxidation in the prefrontal cortex (143%), hippocampus (58%) and striatum (181%), and ω3 fatty acids alone prevented this change in the prefrontal cortex and hippocampus, whereas the co-administration of ω3 fatty acids with VPA prevented the lipoperoxidation in all analyzed brain areas, and the co-administration of ω3 fatty acids with Li prevented this increase only in the prefrontal cortex and striatum...
April 2017: Metabolic Brain Disease