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Fenproporex

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https://www.readbyqxmd.com/read/27253901/safety-and-efficacy-of-fenproporex-for-obesity-treatment-a-systematic-review
#1
Francisco José Roma Paumgartten, Sabrina Schaaf Teixeira Costa Pereira, Ana Cecilia Amado Xavier de Oliveira
OBJECTIVE: To evaluate clinical evidence on the safety and efficacy of fenproporex for treating obesity. METHODS: MEDLINE, LILACS and Cochrane Controlled Trials Register were searched as well as references cited by articles and relevant documents. Two authors independently assessed the studies for inclusion and regarding risk of bias, collected data, and accuracy. Eligible studies were all those placebo-controlled that provided data on the efficacy and safety of Fenproporex to treat obesity...
2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/27246566/omega-3-fatty-acids-and-mood-stabilizers-alter-behavioural-and-energy-metabolism-parameters-in-animals-subjected-to-an-animal-model-of-mania-induced-by-fenproporex
#2
Kizzy Cancelier, Lara M Gomes, Milena Carvalho-Silva, Letícia J Teixeira, Joyce Rebelo, Isabella T Mota, Camila O Arent, Edemilson Mariot, Luiza W Kist, Maurício R Bogo, João Quevedo, Giselli Scaini, Emilio L Streck
Studies have shown that changes in energy metabolism are involved in the pathophysiology of bipolar disorder (BD). It was suggested that omega-3 (ω3) fatty acids have beneficial properties in the central nervous system and that this fatty acid plays an important role in energy metabolism. Therefore, the study aimed to evaluate the effect of ω3 fatty acids alone and in combination with lithium (Li) or valproate (VPA) on behaviour and parameters of energy metabolism in an animal model of mania induced by fenproporex...
May 31, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26718151/validation-and-application-of-a-liquid-chromatography-electrospray-ionization-mass-spectrometric-method-for-determination-of-mazindol-in-human-plasma-and-urine
#3
Marcella Herbstrith de Oliveira, Pâmela Cristina Lukasewicz Ferreira, Graciela Carlos, Fernanda Rodrigues Salazar, Ana Maria Bergold, Flavio Pechansky, Renata Pereira Limberger, Pedro Eduardo Fröehlich
INTRODUCTION: Even after removal of some stimulants, like fenproporex, amfepramone and mazindol, from Brazilian market, the use of these substances is still high, especially by drivers. Mazindol is the second most used anorectic agent in the world acting as an indirect sympathomimetic agonist, having stimulatory action on central nervous system. Plasma is a good matrix to monitor since it reflects the psychomotor effects of these drugs, but unlike urine has an invasive collection; drug levels and detection time are quite low...
May 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/26270078/metabolic-precursors-to-amphetamine-and-methamphetamine
#4
REVIEW
J D Cody
Analysis and interpretation of amphetamine results is a challenging process made difficult by a number of factors. One of the complications comes from determination of the origin of amphetamine or methamphetamine in a sample. Given the relatively rare occasions that either of these two drugs are prescribed, legal prescription of one of these drugs is seldom a reason for positive findings. A number of other precursor compounds are metabolized by the body to amphetamine or methamphetamine, many of which could be used for legitimate reasons...
December 1993: Forensic Science Review
https://www.readbyqxmd.com/read/26247155/acute-administration-of-fenproporex-increased-acetylcholinesterase-activity-in-brain-of-young-rats
#5
Brena P Teodorak, Gabriela K Ferreira, Giselli Scaini, Letícia B Wessler, Alexandra S Heylmann, Pedro Deroza, Samira S Valvassori, Alexandra I Zugno, João Quevedo, Emilio L Streck
Fenproporex is the second most commonly amphetamine-based anorectic consumed worldwide; this drug is rapidly converted into amphetamine, in vivo, and acts by increasing dopamine levels in the synaptic cleft. Considering that fenproporex effects on the central nervous system are still poorly known and that acetylcholinesterase is a regulatory enzyme which is involved in cholinergic synapses and may indirectly modulate the release of dopamine, the present study investigated the effects of acute administration of fenproporex on acetylcholinesterase activity in brain of young rats...
August 2015: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/25218620/effects-of-chronic-administration-of-fenproporex-on-cognitive-and-non-cognitive-behaviors
#6
Cinara L Gonçalves, Camila B Furlanetto, Samira S Valvassori, Daniela V Bavaresco, Roger B Varela, Josiane Budni, João Quevedo, Emilio L Streck
Fenproporex (Fen) is an amphetamine-based anorectic; amphetamine use causes a broad range of severe cognitive deficits and anxiogenic-like effects. In this study we evaluated pharmacological effects of the chronic administration of Fen on cognitive and non-cognitive behaviors. Male adult Wistar rats received intraperitoneal administration of vehicle (control group) or Fen (6.25, 12.5 or 25 mg/kg) for 14 days; the animals were then subjected to habituation and object recognition tasks in open-field apparatus, and elevated plus-maze task...
April 2015: Metabolic Brain Disease
https://www.readbyqxmd.com/read/25039689/analysis-of-ecstasy-tablets-using-capillary-electrophoresis-with-capacitively-coupled-contactless-conductivity-detection
#7
Suely K S S Porto, Thiago Nogueira, Lucas Blanes, Philip Doble, Bruno D Sabino, Claudimir L do Lago, Lúcio Angnes
A method for the identification of 3,4-methylenedioxymethamphetamine (MDMA) and meta-chlorophenylpiperazine (mCPP) was developed employing capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection (C(4) D). Sample extraction, separation, and detection of "Ecstasy" tablets were performed in <10 min without sample derivatization. The separation electrolyte was 20 mm TAPS/Lithium, pH 8.7. Average minimal detectable amounts for MDMA and mCPP were 0.04 mg/tablet, several orders of magnitude lower than the minimum amount encountered in a tablet...
November 2014: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/25038769/simultaneous-analysis-of-amphetamine-type-stimulants-in-plasma-by-solid-phase-microextraction-and-gas-chromatography-mass-spectrometry
#8
Kristiane de Cássia Mariotti, Roselena S Schuh, Priscila Ferranti, Rafael S Ortiz, Daniele Z Souza, Flavio Pechansky, Pedro E Froehlich, Renata P Limberger
Brazil is considered one of the countries with the highest number of amphetamine-type stimulant (ATS) users worldwide, mainly diethylpropion (DIE) and fenproporex (FEN). The use of ATS is mostly linked to diverted prescription stimulants and this misuse is widely associated with (ab)use by drivers. A validated method was developed for the simultaneous analysis of amphetamine (AMP), DIE and FEN in plasma samples employing direct immersion-solid-phase microextraction, and gas chromatographic/mass spectrometric analysis...
September 2014: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/24458547/determination-of-mazindol-in-human-oral-fluid-by-high-performance-liquid-chromatography-electrospray-ionization-mass-spectrometry
#9
Marcella Herbstrith de Oliveira, Graciela Carlos, Ana Maria Bergold, Flavio Pechansky, Renata Pereira Limberger, Pedro Eduardo Fröehlich
Brazil is one of the countries most affected by abuse of stimulant medications by professional drivers, especially fenproporex, amfepramone and mazindol. Even though their sale is banned, they can be found in illegal markets, such as those located on the country's borders. The use of oral fluid to monitor drug levels has many advantages over plasma and urine because it is noninvasive, easier to collect and more difficult to adulterate. The aim of this study was to develop and validate a sensitive and specific method to quantify mazindol in human oral fluid by liquid chromatography-mass spectrometry (LC-MS)...
August 2014: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/24385143/omega-3-fatty-acids-alter-behavioral-and-oxidative-stress-parameters-in-animals-subjected-to-fenproporex-administration
#10
Camila S Model, Lara M Gomes, Giselli Scaini, Gabriela K Ferreira, Cinara L Gonçalves, Gislaine T Rezin, Amanda V Steckert, Samira S Valvassori, Roger B Varela, João Quevedo, Emilio L Streck
Studies have consistently reported the participation of oxidative stress in bipolar disorder (BD). Evidences indicate that omega-3 (ω3) fatty acids play several important roles in brain development and functioning. Moreover, preclinical and clinical evidence suggests roles for ω3 fatty acids in BD. Considering these evidences, the present study aimed to investigate the effects of ω3 fatty acids on locomotor behavior and oxidative stress parameters (TBARS and protein carbonyl content) in brain of rats subjected to an animal model of mania induced by fenproporex...
March 2014: Metabolic Brain Disease
https://www.readbyqxmd.com/read/24287940/a-comparative-study-of-five-centrally-acting-drugs-on-the-pharmacological-treatment-of-obesity
#11
RANDOMIZED CONTROLLED TRIAL
H Suplicy, C L Boguszewski, C M C dos Santos, M do Desterro de Figueiredo, D R Cunha, R Radominski
CONTEXT: No long-term studies have compared centrally acting drugs for treating obesity. OBJECTIVE: To compare the efficacy and safety of diethylpropion (DEP), fenproporex (FEN), mazindol (MZD), fluoxetine (FXT) and sibutramine (SIB) in promoting weight loss. DESIGN AND SETTING: A prospective, randomized, placebo (PCB)-controlled study conducted at a single academic institution. PATIENTS: A total of 174 obese premenopausal women...
August 2014: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/24217638/evaluation-of-na-k-atpase-activity-in-the-brain-of-young-rats-after-acute-administration-of-fenproporex
#12
Gislaine T Rezin, Giselli Scaini, Cinara L Gonçalves, Gabriela K Ferreira, Mariane R Cardoso, Andréa G K Ferreira, Maira J Cunha, Felipe Schmitz, Roger B Varela, João Quevedo, Angela T S Wyse, Emilio L Streck
OBJECTIVES: Fenproporex is an amphetamine-based anorectic which is rapidly converted into amphetamine in vivo. Na+, K+-ATPase is a membrane-bound enzyme necessary to maintain neuronal excitability. Considering that the effects of fenproporex on brain metabolism are poorly known and that Na+, K+-ATPase is essential for normal brain function, this study sought to evaluate the effect of this drug on Na+, K+-ATPase activity in the hippocampus, hypothalamus, prefrontal cortex, and striatum of young rats...
April 2014: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/24126971/fenproporex-increases-locomotor-activity-and-alters-energy-metabolism-and-mood-stabilizers-reverse-these-changes-a-proposal-for-a-new-animal-model-of-mania
#13
Gislaine T Rezin, Camila B Furlanetto, Giselli Scaini, Samira S Valvassori, Cinara L Gonçalves, Gabriela K Ferreira, Isabela C Jeremias, Wilson R Resende, Mariane R Cardoso, Roger B Varela, João Quevedo, Emilio L Streck
Fenproporex (Fen) is converted in vivo into amphetamine, which is used to induce mania-like behaviors in animals. In the present study, we intend to present a new animal model of mania. In order to prove through face, construct, and predictive validities, we evaluated behavioral parameters (locomotor activity, stereotypy activity, and fecal boli amount) and brain energy metabolism (enzymes citrate synthase; malate dehydrogenase; succinate dehydrogenase; complexes I, II, II-III, and IV of the mitochondrial respiratory chain; and creatine kinase) in rats submitted to acute and chronic administration of fenproporex, treated with lithium (Li) and valproate (VPA)...
April 2014: Molecular Neurobiology
https://www.readbyqxmd.com/read/23683905/trends-in-counterfeits-amphetamine-type-stimulants-after-its-prohibition-in-brazil
#14
Kristiane de Cássia Mariotti, Rafael S Ortiz, Daniele Z Souza, Thayse C Mileski, Pedro E Fröehlich, Renata P Limberger
Brazil is one of the world's highest users of anorectic drugs, mainly diethylpropione, fenproporex and sibutramine. The present work focuses on physical and chemical characteristics of 17 counterfeited capsules containing amphetamine-type stimulants (ATS) from three seizures conducted by Brazilian Federal Police. The physical profile was useful in indicating forgery, bring complementary information, but the use of this data singly was not sufficient to distinguish between authentic and counterfeited medicines...
June 10, 2013: Forensic Science International
https://www.readbyqxmd.com/read/23636618/effects-of-acute-and-chronic-administration-of-fenproporex-on-dna-damage-parameters-in-young-and-adult-rats
#15
Cinara L Gonçalves, Gislaine T Rezin, Gabriela K Ferreira, Isabela C Jeremias, Mariane R Cardoso, Samira S Valvassori, Bruna J P Munhoz, Gabriela D Borges, Bruno N Bristot, Daniela D Leffa, Vanessa M Andrade, João Quevedo, Emilio L Streck
Obesity is a chronic and multifactorial disease, whose prevalence is increasing in many countries. Pharmaceutical strategies for the treatment of obesity include drugs that regulate food intake, thermogenesis, fat absorption, and fat metabolism. Fenproporex is the second most commonly consumed amphetamine-based anorectic worldwide; this drug is rapidly converted in vivo into amphetamine, which is associated with neurotoxicity. In this context, the present study evaluated DNA damage parameters in the peripheral blood of young and adult rats submitted to an acute administration and chronic administration of fenproporex...
August 2013: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/23579743/the-use-of-appetite-suppressants-among-health-sciences-undergraduate-students-in-southern-brazil
#16
Carlos Zubaran, Rubia Lazzaretti
OBJECTIVE: To investigate the prevalence of appetite suppressant use among health sciences students in Southern Brazil. METHODS: Undergraduate students (n=300) from seven health science undergraduate courses of the Universidade de Caxias do Sul completed a questionnaire about the use of substances to suppress appetite. RESULTS: A significant percentage (15%; n=45) of research participants used appetite suppressants at least once in their lives...
January 2013: Einstein
https://www.readbyqxmd.com/read/23511002/first-trimester-in-utero-exposure-to-anorectics-a-french-collaborative-study-with-special-reference-to-dexfenfluramine
#17
T Vial, E Robert, P Carlier, E Bertolotti, A Brun
A collaborative study with 8 Teratology Information Centres was undertaken to collect data on anorectic exposures (amfepramone, clobenzorex, dexfenfluramine, fenfluramine, fenproporex) during pregnancy. Two hundred and ninety seven prospective enquiries were analysed of which 285 exposures occurred during the first trimester. Outcome of pregnancy was known for 164 of these cases. Voluntary or medical abortion was decided in 30 cases (18%), spontaneous abortion occurred in 14 cases (8.5%), extrauterine pregnancy in 1 patient and fetal death following drug abuse in another...
1992: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/23342978/amphetamine-type-medicines-a-review-of-pharmacokinetics-pharmacodynamics-and-toxicological-aspects
#18
REVIEW
Kristianee C Mariotti, Luciana G Rossato, Pedro E Fröehlich, Renata P Limberger
Amphetamine-like drugs are sympathomimetic agents with marked central and peripheral stimulant properties. Despite the street illegal drugs such as amphetamine and ecstasy, some amphetamine-like compounds are also legally marketed under medical prescription in the treatment of attention deficit-hyperactivity disorder (methylphenidate) and obesity/overweight (fenproporex and diethylpropione). However, similar with what happens with their illicit analogues, therapeutic amphetamine-like drugs also share important toxicological risks...
November 2013: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/23245251/screening-of-pharmacologic-adulterant-classes-in-herbal-formulations-using-voltammetry-of-microparticles
#19
Antonio Doménech-Carbó, Mariele Martini, Leandro Machado de Carvalho, Carine Viana, María Teresa Doménech-Carbó, Miguel Silva
A solid state electrochemical method for screening different families of adulterant chemicals illegally added to commercial phytotherapuetic formulations is described. The proposed method, based on the voltammetry of microparticles approach, permits a fast and sensitive way to distinguish between anorexics (amfepramone, fenproporex, sibutramine), benzozodiazepinic anxiolytics (clonazepam, flurazepam, alprazolam, midazolam, medazepam, chlordiazepoxide, diazepam), antidepressants (bupropione, fluoxetine, sertraline, paroxetine), diuretics (hydrochlorothiazide, furosemide, chlortalidone, amiloride, spironolactone), and hypoglycemics (glimepiride, chlorpropamide, glibenclamide) based on characteristic voltammetric signals recorded on solid micro- or nanosamples attached to graphite electrodes immersed into aqueous electrolytes...
February 23, 2013: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/22939380/ultra-high-performance-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry-screening-method-for-direct-analysis-of-designer-drugs-spice-and-stimulants-in-oral-fluid
#20
Sabina Strano-Rossi, Luca Anzillotti, Erika Castrignanò, Francesco Saverio Romolo, Marcello Chiarotti
An ultra high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) screening method for the direct analysis in oral fluid (OF) of 24 drugs, including new synthetic cannabinoids and so-called "smart" designer drugs, in a single chromatographic run was set up. Benzylpiperazine, methylone, 5,6-methylenedioxy-2-aminoindane (MDAI), fenproporex, 4-fluoroamphetamine (4-FA), 4-methyl-N-ethylcathinone (4-MEC), 4-methylamphetamine (4-MA), methylbenzodioxolylbutanamine (MBDB), mephedrone, methylthioamphetamine (MTA), methylenedioxypyrovalerone (MDPV), mefenorex, nabilone, furfenorex, clobenzorex, JWH-200, AM 694, JWH-250, JWH-073, JWH-018, JWH-019, JWH-122, HU 210 and CP 47497 were determined in a chromatographic run of 9 min only with no sample pre-treatment, after addition of ISs and dilution in mobile phase A...
October 5, 2012: Journal of Chromatography. A
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