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https://www.readbyqxmd.com/read/28212289/the-effects-of-myo-inositol-and-b-and-d-vitamin-supplementation-in-the-db-mouse-model-of-gestational-diabetes-mellitus
#1
Jasmine F Plows, Florence Budin, Rebecka A M Andersson, Valerie J Mills, Katherine Mace, Sandra T Davidge, Mark H Vickers, Philip N Baker, Irma Silva-Zolezzi, Joanna L Stanley
Gestational diabetes mellitus (GDM) is a growing concern, affecting an increasing number of pregnant women worldwide. By predisposing both the affected mothers and children to future disease, GDM contributes to an intergenerational cycle of obesity and diabetes. In order to stop this cycle, safe and effective treatments for GDM are required. This study sought to determine the treatment effects of dietary supplementation with myo-inositol (MI) and vitamins B2, B6, B12, and D in a mouse model of GDM (pregnant db/+ dams)...
February 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28158304/validation-of-two-portable-bioelectrical-impedance-analyses-for-the-assessment-of-body-composition-in-school-age-children
#2
Li-Wen Lee, Yu-San Liao, Hsueh-Kuan Lu, Pei-Lin Hsiao, Yu-Yawn Chen, Ching-Chi Chi, Kuen-Chang Hsieh
BACKGROUND: Bioelectrical impedance analysis (BIA) is a convenient and child-friendly method for longitudinal analysis of changes in body composition. However, most validation studies of BIA have been performed on adult Caucasians. The present cross-sectional study investigated the validity of two portable BIA devices, the Inbody 230 (BIA8MF) and the Tanita BC-418 (BIA8SF), in healthy Taiwanese children. METHODS: Children aged 7-12 years (72 boys and 78 girls) were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28150350/nutrient-intakes-and-compliance-with-nutrient-recommendations-in-children-aged-1-4-years-in-ireland
#3
J Walton, L Kehoe, B A McNulty, A P Nugent, A Flynn
BACKGROUND: The early childhood years represent a period of rapid growth and development characterised by unique requirements for energy and individual nutrients. METHODS: The present study uses data from the National Pre-School Nutrition Survey, a nationally representative sample of Irish children (1-4 years) (n = 500), aiming to estimate energy and nutrient intakes across age and compliance with recommendations (UK and European). A 4-day weighed food-record was used to collect dietary data and statistical modelling (National Cancer Institute method) was applied to estimate usual nutrient intakes...
February 2, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28121970/resorbable-mesh-cranioplasty-repair-of-bilateral-cerebrospinal-fluid-leaks-following-pediatric-simultaneous-bilateral-auditory-brainstem-implant-surgery
#4
Giacomo Colletti, Marco Mandalà, Vittorio Colletti, Alberto Deganello, Fabiana Allevi, Liliana Colletti
OBJECTIVE: To present a child with cochlear nerve deficiency (CND) who received simultaneous bilateral simultaneous auditory brainstem implants (BS-ABI) and subsequently presented with bilateral cerebrospinal fluid (CSF) leaks unresponsive to standard treatments. To propose a novel rigid retrosigmoid cranioplasty for treating and preventing CSF leaks in children at high risk for this complication. PATIENT: A 3.5-year-old child with CND, vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities, coloboma, heart defect, atresia choanae, retarded growth and development, genital abnormality, and ear abnormality, Arnold Chiari malformation, previous treated tracheo-esophageal fistula underwent BS-ABI...
January 24, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28118352/using-genetic-variation-to-explore-the-causal-effect-of-maternal-pregnancy-adiposity-on-future-offspring-adiposity-a-mendelian-randomisation-study
#5
Rebecca C Richmond, Nicholas J Timpson, Janine F Felix, Tom Palmer, Romy Gaillard, George McMahon, George Davey Smith, Vincent W Jaddoe, Debbie A Lawlor
BACKGROUND: It has been suggested that greater maternal adiposity during pregnancy affects lifelong risk of offspring fatness via intrauterine mechanisms. Our aim was to use Mendelian randomisation (MR) to investigate the causal effect of intrauterine exposure to greater maternal body mass index (BMI) on offspring BMI and fat mass from childhood to early adulthood. METHODS AND FINDINGS: We used maternal genetic variants as instrumental variables (IVs) to test the causal effect of maternal BMI in pregnancy on offspring fatness (BMI and dual-energy X-ray absorptiometry [DXA] determined fat mass index [FMI]) in a MR approach...
January 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28112969/validity-of-segmental-bioelectrical-impedance-analysis-for-estimating-fat-free-mass-in-children-including-overweight-individuals
#6
COMPARATIVE STUDY
Megumi Ohta, Taishi Midorikawa, Yuki Hikihara, Yoshihisa Masuo, Shizuo Sakamoto, Suguru Torii, Yasuo Kawakami, Tetsuo Fukunaga, Hiroaki Kanehisa
This study examined the validity of segmental bioelectrical impedance (BI) analysis for predicting the fat-free masses (FFMs) of whole-body and body segments in children including overweight individuals. The FFM and impedance (Z) values of arms, trunk, legs, and whole body were determined using a dual-energy X-ray absorptiometry and segmental BI analyses, respectively, in 149 boys and girls aged 6 to 12 years, who were divided into model-development (n = 74), cross-validation (n = 35), and overweight (n = 40) groups...
February 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28105511/bone-density-in-the-obese-child-clinical-considerations-and-diagnostic-challenges
#7
Jennifer C Kelley, Nicola Crabtree, Babette S Zemel
The prevalence of obesity in children has reached epidemic proportions. Concern about bone health in obese children, in part, derives from the potentially increased fracture risk associated with obesity. Additional risk factors that affect bone mineral accretion, may also contribute to obesity, such as low physical activity and nutritional factors. Consequences of obesity, such as inflammation, insulin resistance, and non-alcoholic fatty liver disease, may also affect bone mineral acquisition, especially during the adolescent years when rapid increases in bone contribute to attaining peak bone mass...
January 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28094879/nutritional-inflammatory-and-ecological-correlates-of-maternal-retinol-allocation-to-breast-milk-in-agro-pastoral-ariaal-communities-of-northern-kenya
#8
Masako Fujita, Yun-Jia Lo, Eleanor Brindle
OBJECTIVES: Vitamin A (VA) is an essential micronutrient required for a range of biological functions throughout life. VA deficiency (VAD) claims an estimated 1 million preschool children's lives annually. Human milk is enriched with VA (retinol) from the maternal blood, which originates from the hepatic reserve and dietary intake. Secreting retinol into milk will benefit the nursing infant through breast milk, but retaining retinol is also important for the maternal health. Previous studies found that the public health intervention of high-dose VA supplementation to lactating mothers did not significantly lower child mortality...
January 17, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28088421/the-influence-of-ultra-pasteurization-by-indirect-heating-versus-direct-steam-injection-on-skim-and-2-fat-milks
#9
A P Lee, D M Barbano, M A Drake
Fluid milk is traditionally pasteurized by high temperature, short time (HTST) pasteurization, which requires heating to at least 72°C for 15 s. Ultra-pasteurization (UP) extends milk shelf life and is defined as heating to at least 138°C for 2 s. The UP process can be done by indirect heating (IND) or by direct steam injection (DSI). The influence of these 2 UP methods on milk flavor has not been widely investigated. The objective of this study was to compare the effect of HTST, IND-UP, and DSI-UP on sensory perception of fluid milk...
March 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28079262/pediatric-obesity-pharmacokinetic-alterations-and-effects-on-antimicrobial-dosing
#10
Stephanie Natale, John Bradley, William Huy Nguyen, Tri Tran, Pamela Ny, Kirsten La, Eva Vivian, Jennifer Le
BACKGROUND: Limited data exist for appropriate drug dosing in obese children. This comprehensive review summarizes pharmacokinetic alterations that occur with age and obesity, and these effects on antimicrobial dosing. A thorough comparison of different measures of body weight and specific antimicrobial agents, including cefazolin, cefepime, ceftazidime, daptomycin, doripenem, gentamicin, linezolid, meropenem, piperacill-tazobactam, tobramycin, vancomycin, and voriconazole, are presented...
January 12, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28077151/multi-strategic-intervention-to-enhance-implementation-of-healthy-canteen-policy-a-randomised-controlled-trial
#11
Luke Wolfenden, Nicole Nathan, Lisa M Janssen, John Wiggers, Kathryn Reilly, Tessa Delaney, Christopher M Williams, Colin Bell, Rebecca Wyse, Rachel Sutherland, Libby Campbell, Christophe Lecathelinais, Chris Oldmeadow, Megan Freund, Sze Lin Yoong
BACKGROUND: Internationally, governments have implemented school-based nutrition policies to restrict the availability of unhealthy foods from sale. The aim of the trial was to assess the effectiveness of a multi-strategic intervention to increase implementation of a state-wide healthy canteen policy. The impact of the intervention on the energy, total fat, and sodium of children's canteen purchases and on schools' canteen revenue was also assessed. METHODS: Australian primary schools with a canteen were randomised to receive a 12-14-month, multi-strategic intervention or to a no intervention control group...
January 11, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28076316/changes-of-thyroid-hormonal-status-in-patients-receiving-ketogenic-diet-due-to-intractable-epilepsy
#12
Engin Kose, Orkide Guzel, Korcan Demir, Nur Arslan
BACKGROUND: Ketogenic diet (KD), which is high in fat and low in carbohydrates, mimics the metabolic state of starvation and is used therapeutically for pharmacoresistant epilepsy. It is known that generation of triiodothyronine (T3) from thyroxine (T4) decreases during fasting periods. The aim of this study was to evaluate the thyroid function of children receiving KD for at least 1 year due to drug-resistant epilepsy. METHODS: A total of 120 patients [63 males, 52...
January 11, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28059054/randomised-controlled-trial-evaluating-the-effectiveness-and-cost-effectiveness-of-families-for-health-a-family-based-childhood-obesity-treatment-intervention-delivered-in-a-community-setting-for-ages-6-to-11-years
#13
Wendy Robertson, Joanna Fleming, Atiya Kamal, Thomas Hamborg, Kamran A Khan, Frances Griffiths, Sarah Stewart-Brown, Nigel Stallard, Stavros Petrou, Douglas Simkiss, Elizabeth Harrison, Sung Wook Kim, Margaret Thorogood
BACKGROUND: Effective programmes to help children manage their weight are required. 'Families for Health' focuses on a parenting approach, designed to help parents develop their parenting skills to support lifestyle change within the family. Families for Health version 1 showed sustained reductions in mean body mass index (BMI) z-score after 2 years in a pilot project. OBJECTIVE: The aim was to evaluate its effectiveness and cost-effectiveness in a randomised controlled trial (RCT)...
January 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28056273/-study-on-the-contribution-rate-of-follow-up-formula-to-the-nutrient-intake-of-infants-and-young-children-aged-7-24-months-in-china
#14
H Z Li, H X Jia, D Liang, T T Deng, L T Niu, J H Han
Objective: To determine the contribution of follow-up formula (FUF) to the nutrient intake of 7-24-month-old infants and young children. Methods: The cluster random sampling method and the convenience sampling method were used in combination, and geographic and economic factors were taken into consideration. Four areas of China (Beijing, Hebei, Guangxi, Guangdong) were selected, with 120 infants chosen from each of these areas (half of which were 7-12 months old, and half were 13-24 months old). A dietary survey was completed by a continuous 24-hour weighing method over two days...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28008727/nutrient-composition-of-premixed-and-packaged-complementary-foods-for-sale-in-low-and-middle-income-countries-lack-of-standards-threatens-infant-growth
#15
William A Masters, Marc D Nene, Winnie Bell
Premixed flours for infant porridge are increasingly produced and sold in developing countries to complement continued breastfeeding. Such complementary food (CF) products have known efficacy against malnutrition in children from 6 to 24 months of age, but ingredient ratios and production processes may vary. This study provides the first systematic measurement of their actual nutrient composition. We purchased samples of 108 premixed CF products in 22 low- and middle-income countries, and commissioned blind laboratory measurement of each product's macronutrients and micronutrients...
December 22, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28004412/conceptualization-of-physical-exercise-and-keeping-fit-by-child-wheelchair-users-and-their-parents
#16
Jane Noyes, Llinos Haf Spencer, Nathan Bray, Hans-Peter Kubis, Richard P Hastings, Matthew Jackson, Thomas D O'Brien
AIM: To gain a better understanding of how children aged 6-18 years who use wheelchairs and their families conceptualized physical exercise and keeping fit. BACKGROUND: Disabled children with reduced mobility are commonly overweight and unfit. Nurse-led health screening programmes in schools commonly exclude disabled children if they cannot use standard weighing scales or stand against height measuring sticks. DESIGN: Qualitative interview study at two time points over 6 months with children who use wheelchairs and their families...
November 16, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27916866/relationship-between-soft-drink-consumption-and-obesity-in-9-11-years-old-children-in-a-multi-national-study
#17
Peter T Katzmarzyk, Stephanie T Broyles, Catherine M Champagne, Jean-Philippe Chaput, Mikael Fogelholm, Gang Hu, Rebecca Kuriyan, Anura Kurpad, Estelle V Lambert, Jose Maia, Victor Matsudo, Timothy Olds, Vincent Onywera, Olga L Sarmiento, Martyn Standage, Mark S Tremblay, Catrine Tudor-Locke, Pei Zhao
The purpose of this study was to determine the association between regular (sugar containing) and diet (artificially sweetened) soft drink consumption and obesity in children from 12 countries ranging in levels of economic and human development. The sample included 6162 children aged 9-11 years. Information on soft drink consumption was obtained using a food frequency questionnaire. Percentage body fat (%BF) was estimated by bio-electrical impedance analysis, body mass index (BMI) z-scores were computed using World Health Organization reference data, and obesity was defined as a BMI > +2 standard deviations (SD)...
November 30, 2016: Nutrients
https://www.readbyqxmd.com/read/27899001/drug-interventions-for-the-treatment-of-obesity-in-children-and-adolescents
#18
REVIEW
Emma Mead, Greg Atkinson, Bernd Richter, Maria-Inti Metzendorf, Louise Baur, Nicholas Finer, Eva Corpeleijn, Claire O'Malley, Louisa J Ells
BACKGROUND: Child and adolescent obesity has increased globally, and can be associated with significant short- and long-term health consequences. OBJECTIVES: To assess the efficacy of drug interventions for the treatment of obesity in children and adolescents. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, PubMed (subsets not available on Ovid), LILACS as well as the trial registers ICTRP (WHO) and ClinicalTrials.gov. Searches were undertaken from inception to March 2016...
November 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27890489/spinal-muscular-atrophy-types-i-and-ii-what-are-the-differences-in%C3%A2-body-composition-and-resting-energy-expenditure
#19
Simona Bertoli, Ramona De Amicis, Chiara Mastella, Giulia Pieri, Ester Giaquinto, Alberto Battezzati, Alessandro Leone, Giovanni Baranello
BACKGROUND & AIMS: Different neuromuscular functional domains in types I and II Spinal Muscular Atrophy (SMAI and SMAII) could lead to differences in body composition (BC) and resting energy expenditure (REE). Their identification could provide the key to defining appropriate strategies in clinical dietary management, but data comparing SMAI and SMAII in terms of BC and REE are not yet available. We measured total and regional fat (FM), lean (LBM), mineral (BMC) masses, body water (total, intra- and extra-cellular, TBW, ICW, ECW) and REE in a sample of SMAI and II children, matched for age and sex, and also adjusting for body size to compare these features of the two SMA phenotypes...
November 16, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27889809/reversal-of-type-2-diabetes-in-youth-who-adhere-to-a-very-low-energy-diet-a-pilot-study
#20
Megan L Gow, Louise A Baur, Nathan A Johnson, Chris T Cowell, Sarah P Garnett
AIMS/HYPOTHESIS: The aim of the study was to investigate whether a very-low-energy diet (VLED) is a feasible and acceptable treatment option for type 2 diabetes in children and adolescents, and whether adherence can lead to rapid weight loss, reversal of type 2 diabetes and reduced liver fat as seen in adult studies. METHODS: Eight participants with type 2 diabetes and obesity, aged 7-16 years, non-medicated (n = 1) or treated with metformin (n = 7) and in some cases insulin (n = 3), followed a VLED (<3360 kJ/day) for 8 weeks, then transitioned to a hypocaloric diet (∼6300 kJ/day) that they followed to 34 weeks...
March 2017: Diabetologia
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