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Ravi Majeti

Michael Zhang, Gregor Hutter, Suzana A Kahn, Tej D Azad, Sharareh Gholamin, Chelsea Y Xu, Jie Liu, Achal S Achrol, Chase Richard, Pia Sommerkamp, Matthew Kenneth Schoen, Melissa N McCracken, Ravi Majeti, Irving Weissman, Siddhartha S Mitra, Samuel H Cheshier
Tumor-associated macrophages (TAMs) represent an important cellular subset within the glioblastoma (WHO grade IV) microenvironment and are a potential therapeutic target. TAMs display a continuum of different polarization states between antitumorigenic M1 and protumorigenic M2 phenotypes, with a lower M1/M2 ratio correlating with worse prognosis. Here, we investigated the effect of macrophage polarization on anti-CD47 antibody-mediated phagocytosis of human glioblastoma cells in vitro, as well as the effect of anti-CD47 on the distribution of M1 versus M2 macrophages within human glioblastoma cells grown in mouse xenografts...
2016: PloS One
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