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Artificial lung

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https://www.readbyqxmd.com/read/28281366/artificial-pneumothorax-a-safe-and-simple-method-to-relieve-pain-during-microwave-ablation-of-subpleural-lung-malignancy
#1
Xiaowei Hou, Xingjun Zhuang, Haiwen Zhang, Kai Wang, Yuanxin Zhang
BACKGROUND: Microwave ablation has been extensively used for eliminating pulmonary tumors; however, it is usually associated with severe pain under local anesthesia. Decreasing the power and shortening the ablation time can help to relieve the pain; however, this leads to incomplete ablation and an increasing recurrence rate. This research aims to employ an artificial pneumothorax to increase both the curative effect and pain relief during the ablation procedure. MATERIAL AND METHODS: From July 2013 to January 2015, nine patients presenting with 10 subpleural lung tumors (age: 44-78 years) with a high possibility of severe pain underwent the artificial pneumothorax during microwave ablation...
February 14, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28272485/construction-and-immunogenicity-of-a-recombinant-swinepox-virus-expressing-a-multi-epitope-peptide-for-porcine-reproductive-and-respiratory-syndrome-virus
#2
Huixing Lin, Zhe Ma, Xin Hou, Lei Chen, Hongjie Fan
To characterize neutralizing mimotopes, phages were selected from a 12-mer phage display library using three anti-porcine reproductive and respiratory syndrome virus (PRRSV) neutralizing monoclonal antibodies: (1) A1; (2) A2; and (3) A7. Of these, A2 and A7 recognize the mimotope, P2, which contains the SRHDHIH motif, which has conserved consensus sequences from amino acid positions 156 to 161 in the N-terminal ectodomain of GP3. The artificial multi-epitope gene, mp2, was designed by combining three repeats of the mimotope P2...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28265740/reconstruction-with-scapular-hemiarthroplasty-endoprosthesis-after-scapulectomy-for-malignant-tumour
#3
Li Min, Yong Zhou, Fan Tang, Wenli Zhang, Yi Luo, Hong Duan, Chongqi Tu
PURPOSE: Recently, endoprosthesis reconstruction has been used for scapular malignant tumours. Our aim is to present and evaluate the clinical indications, peri-operative technique, and mid-term clinical results. METHODS: Scapular hemiarthroplasty after total scapulectomy has been performed in 15 patients between 2011 and 2014. Clinical records and radiographs were evaluated retrospectively. RESULTS: The average follow-up was 41.2 months...
March 6, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28248570/the-diacetyl-exposed-human-airway-epithelial-secretome-new-insights-into-flavoring-induced-airways-disease
#4
David M Brass, William M Gwinn, Ashlee M Valente, Francine L Kelly, Christie D Brinkley, Andrew E Nagler, M Arthur Moseley, Daniel L Morgan, Scott M Palmer, Matthew W Foster
Bronchiolitis obliterans (BO) is an increasingly important lung disease characterized by fibroproliferative airway lesions and decrements in lung function. Occupational exposure to the artificial food flavoring ingredient diacetyl, commonly used to impart a buttery flavor to microwave popcorn, has been associated with BO development. In the occupational setting, diacetyl vapor is first encountered by the airway epithelium. To better understand the effects of diacetyl vapor on the airway epithelium we used an unbiased proteomic approach to characterize both the apical and basolateral secretomes of air liquid interface cultures of primary human airway epithelial cells from four unique donors after exposure to an occupationally relevant ~1100 ppm of diacetyl vapor or PBS as a control on alternating days...
March 1, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28243966/robustness-of-two-different-methods-of-monitoring-respiratory-system-compliance-during-mechanical-ventilation
#5
Gaetano Perchiazzi, Christian Rylander, Mariangela Pellegrini, Anders Larsson, Göran Hedenstierna
Robustness measures the performance of estimation methods when they work under non-ideal conditions. We compared the robustness of artificial neural networks (ANNs) and multilinear fitting (MLF) methods in estimating respiratory system compliance (C RS) during mechanical ventilation (MV). Twenty-four anaesthetized pigs underwent MV. Airway pressure, flow and volume were recorded at fixed intervals after the induction of acute lung injury. After consecutive mechanical breaths, an inspiratory pause (BIP) was applied in order to calculate CRS using the interrupter technique...
February 27, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28243535/modeling-using-clinical-examination-indicators-predicts-interstitial-lung-disease-among-patients-with-rheumatoid-arthritis
#6
Yao Wang, Wuqi Song, Jing Wu, Zhangming Li, Fengyun Mu, Yang Li, He Huang, Wenliang Zhu, Fengmin Zhang
Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA) that is well-defined as a chronic systemic autoimmune disease. A proportion of patients with RA-associated ILD (RA-ILD) develop pulmonary fibrosis (PF), resulting in poor prognosis and increased lifetime risk. We investigated whether routine clinical examination indicators (CEIs) could be used to identify RA patients with high PF risk. A total of 533 patients with established RA were recruited in this study for model building and 32 CEIs were measured for each of them...
2017: PeerJ
https://www.readbyqxmd.com/read/28223376/bactericidal-and-fungicidal-activity-of-n-chlorotaurine-is-enhanced-in-cystic-fibrosis-sputum-medium
#7
Martina Gruber, Ivan Moser, Markus Nagl, Michaela Lackner
Lung infections with multiresistant pathogens are a major problem of patients suffering from cystic fibrosis (CF). N-chlorotaurine (NCT), a microbicidal active chlorine compound with no resistance development, is well tolerated upon inhalation. The aim of this study was to investigate NCT on its bactericidal and fungicidal activity in vitro in artificial sputum medium (ASM) mimicking the composition of cystic fibrosis mucus.The medium was inoculated with bacteria (Staphylococcus aureus including some MRSA strains, Pseudomonas aeruginosa, Escherichia coli) or spores of fungi (Aspergillus fumigatus, Aspergillus terreus, Candida albicans, Scedosporium apiospermum, Scedosporium boydii, Lomentospora prolificans, Scedosporium aurantiacum, Scedosporium minutisporum, Exophiala dermatitidis, Geotrichum sp...
February 21, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28215891/thoracic-ultrasound-assessment-of-lung-consolidation-at-weaning-in-holstein-dairy-heifers-reproductive-performance-and-survival
#8
A G V Teixeira, J A A McArt, R C Bicalho
The objective of this study was to determine the association of lung consolidation at weaning with later reproductive performance and survival. Ultrasonography of the lungs was performed at 60 d of life in recently weaned Holstein heifer calves from a single farm in New York State. Thoracic screening covered the right 2nd through 10th and left 3rd through 9th intercostal spaces and was performed using a 6.2-MHz linear transducer. Each calf was classified as not having lung consolidation (hyperechoic line with reverberation artifact with or without comet tail) or with lung consolidation (any detectable heterogeneous hypoechoic area)...
February 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28212205/spontaneous-breathing-during-extracorporeal-membrane-oxygenation-in-acute-respiratory-failure
#9
Stefania Crotti, Nicola Bottino, Giulia Maria Ruggeri, Elena Spinelli, Daniela Tubiolo, Alfredo Lissoni, Alessandro Protti, Luciano Gattinoni
BACKGROUND: We evaluate the clinical feasibility of spontaneous breathing on extracorporeal membrane oxygenation and the interactions between artificial and native lungs in patients bridged to lung transplant or with acute exacerbation of chronic obstructive pulmonary disease (COPD) or acute respiratory distress syndrome. METHODS: The clinical course of a total of 48 patients was analyzed. Twenty-three of 48 patients were enrolled in the prospective study (nine bridged to lung transplant, six COPD, and eight acute respiratory distress syndrome)...
April 2017: Anesthesiology
https://www.readbyqxmd.com/read/28191852/artificial-chemical-reporter-targeting-strategy-using-bioorthogonal-click-reaction-for-improving-active-targeting-efficiency-of-tumor
#10
Hong Yeol Yoon, Min Lee Shin, Man Kyu Shim, Sangmin Lee, Jin Hee Na, Heebeom Koo, Hyukjin Lee, Jong-Ho Kim, Kuen Yong Lee, Kwangmeyung Kim, Ick Chan Kwon
Biological ligands such as aptamer, antibody, glucose and peptide have been widely used to bind specific surface molecules or receptors in tumor cells or subcellular structures to improve tumor-targeting efficiency of nanoparticles. However, this active targeting strategy has limitations for tumor targeting due to inter- and intra-heterogeneity of tumors. In this study, we demonstrated an alternative active targeting strategy using metabolic engineering and bioorthogonal click reaction to improve tumor-targeting efficiency of nanoparticles...
February 13, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28187049/fiber-bundle-design-for-an-integrated-wearable-artificial-lung
#11
Shalv P Madhani, Brian J Frankowski, William J Federspiel
Mechanical ventilation and ECMO are the only viable treatment options for lung failure patients at the end stage, including ARDS and COPD. These treatments however are associated with high morbidity and mortality due to long wait times for lung transplant. Contemporary clinical literature has shown ambulation improves post-transplant outcomes in lung failure patients. Given this, we are developing the PAAL, a truly wearable artificial lung that allows for ambulation. In this study, we targeted 180 ml/min oxygenation and determined the form factor for a hollow fiber membrane (HFM) bundle for the PAAL...
February 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28170370/development-of-a-gene-panel-for-next-generation-sequencing-of-clinically-relevant-mutations-in-cell-free-dna-from-cancer-patients
#12
Umberto Malapelle, Clara Mayo de-Las-Casas, Danilo Rocco, Monica Garzon, Pasquale Pisapia, Nuria Jordana-Ariza, Maria Russo, Roberta Sgariglia, Caterina De Luca, Francesco Pepe, Alejandro Martinez-Bueno, Daniela Morales-Espinosa, María González-Cao, Niki Karachaliou, Santiago Viteri Ramirez, Claudio Bellevicine, Miguel Angel Molina-Vila, Rafael Rosell, Giancarlo Troncone
BACKGROUND: When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use in ultra-deep sequencing to identify such mutations in cfDNA. METHODS: Our panel ('SiRe') covers 568 mutations in six genes (EGFR, KRAS, NRAS, BRAF, cKIT and PDGFRα)involved in non-small-cell lung cancer (NSCLC), gastrointestinal stromal tumour, colorectal carcinoma and melanoma...
March 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28145560/survival-following-lung-transplantation-for-artificial-stone-silicosis-relative-to-idiopathic-pulmonary-fibrosis
#13
Dror Rosengarten, Benjamin D Fox, Elizabeth Fireman, Paul D Blanc, Victoria Rusanov, Oren Fruchter, Yael Raviv, Osnat Shtraichman, Milton Saute, Mordechai R Kramer
BACKGROUND: Silicosis is a progressive lung disease resulting from the inhalation of respirable crystalline silica. Lung transplantation is the only treatment for end-stage silicosis. The aim of this study was to analyze the survival experience following lung transplantation among patients with silicosis. METHODS: We reviewed data for all patients who underwent lung transplantation for silicosis and a matched group undergoing lung transplantation for idiopathic pulmonary fibrosis (IPF) at a single medical center between March 2006 and the end of December 2013...
February 1, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28130689/comparison-of-machine-learning-methods-for-classifying-mediastinal-lymph-node-metastasis-of-non-small-cell-lung-cancer-from-18-f-fdg-pet-ct-images
#14
Hongkai Wang, Zongwei Zhou, Yingci Li, Zhonghua Chen, Peiou Lu, Wenzhi Wang, Wanyu Liu, Lijuan Yu
BACKGROUND: This study aimed to compare one state-of-the-art deep learning method and four classical machine learning methods for classifying mediastinal lymph node metastasis of non-small cell lung cancer (NSCLC) from (18)F-FDG PET/CT images. Another objective was to compare the discriminative power of the recently popular PET/CT texture features with the widely used diagnostic features such as tumor size, CT value, SUV, image contrast, and intensity standard deviation. The four classical machine learning methods included random forests, support vector machines, adaptive boosting, and artificial neural network...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28127344/helminth-parasites-of-wild-boars-sus-scrofa-in-bushehr-province-southwestern-iran
#15
Majid Mansouri, Bahador Sarkari, Gholam Reza Mowlavi
BACKGROUND: Wild boars, Sus scrofa, of wide distribution considered as a potential source of zoonotic parasites. The current study aimed to assess the prevalence of helminth infections in wild boars in the Persian Gulf coastal area (Bushehr Province), Southwestern Iran. METHODS: Twenty-five wild boars, including 11 males and 14 females, were collected during a course of vertebrate pest control in the Bushehr Province, southwestern Iran in 2013. The specimen were immediately dissected and carefully searched for the parasites...
July 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28125027/in-vitro-investigations-of-human-bioaccessibility-from-reference-materials-using-simulated-lung-fluids
#16
Aurélie Pelfrêne, Mark R Cave, Joanna Wragg, Francis Douay
An investigation for assessing pulmonary bioaccessibility of metals from reference materials is presented using simulated lung fluids. The objective of this paper was to contribute to an enhanced understanding of airborne particulate matter and its toxic potential following inhalation. A large set of metallic elements (Ba, Cd, Co, Cr, Cu, Mn, Ni, Pb, Sr, and Zn) was investigated using three lung fluids (phosphate-buffered saline, Gamble's solution and artificial lysosomal fluid) on three standard reference materials representing different types of particle sources...
January 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28113310/seamless-lesion-insertion-for-data-augmentation-in-cad-training
#17
Aria Pezeshk, Nicholas Petrick, Weijie Chen, Berkman Sahiner
The performance of a classifier is largely dependent on the size and representativeness of data used for its training. In circumstances where accumulation and/or labeling of training samples is difficult or expensive, such as medical applications, data augmentation can potentially be used to alleviate the limitations of small datasets. We have previously developed an image blending tool that allows users to modify or supplement an existing CT or mammography dataset by seamlessly inserting a lesion extracted from a source image into a target image...
December 14, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28110738/risk-analysis-of-lung-cancer-and-effects-of-stress-level-on-cancer-risk-through-neuro-fuzzy-model
#18
Atınç Yılmaz, Seçkin Arı, Ümit Kocabıçak
A significant number of people pass away due to limited medical resources for the battle with cancer. Fatal cases can be reduced by using the computational techniques in the medical and health system. If the cancer is diagnosed early, the chance of successful treatment increases. In this study, the risk of getting lung cancer will be obtained and patients will be provided with directions to exterminate the risk. After calculating the risk value for lung cancer, status of the patient's susceptibility and resistance to stress is used in determining the effects of stress to disease...
December 2016: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28109960/rna-nanoparticle-based-targeted-therapy-for-glioblastoma-through-inhibition-of-oncogenic-mir-21
#19
Tae Jin Lee, Ji Young Yoo, Dan Shu, Hui Li, Jianying Zhang, Jun-Ge Yu, Alena Cristina Jaime-Ramirez, Mario Acunzo, Giulia Romano, Ri Cui, Hui-Lung Sun, Zhenghua Luo, Matthew Old, Balveen Kaur, Peixuan Guo, Carlo M Croce
Targeted inhibition of oncogenic miRNA-21 has been proposed to treat glioblastoma by rescuing tumor suppressors, PTEN and PDCD4. However, systemic delivery of anti-miR-21 sequences requires a robust and efficient delivery platform to successfully inhibit this druggable target. Three-way-junction (3WJ)-based RNA nanoparticles (RNP), artificially derived from pRNA of bacteriophage phi29 DNA packaging motor, was recently shown to target glioblastoma. Here, we report that multi-valent folate (FA)-conjugated 3WJ RNP constructed to harbor anti-miR-21 LNA sequences (FA-3WJ-LNA-miR21) specifically targeted and delivered anti-miR-21 LNA and knocked down miR-21 expression in glioblastoma cells in vitro and in vivo with favorable biodistribution...
January 18, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28093826/highly-sensitive-detection-of-e2-activity-in-ubiquitination-using-an-artificial-ring-finger
#20
Kazuhide Miyamoto, Miho Sumida, Mayumi Yuasa-Sunagawa, Kazuki Saito
The ubiquitin-conjugating (E2) enzymes of protein ubiquitination are associated with various diseases such as leukemia, lung cancer, and breast cancer. Rapid and accurate detection of E2 enzymatic activities remains poor. Here, we described the detection of E2 activity on a signal accumulation ISFET biosensor (AMIS sensor) using an artificial RING finger (ARF). The use of ARF enables the simplified detection of E2 activity without a substrate. The high-sensitivity quantitative detection of E2 activities was demonstrated via real-time monitoring over a response range of femtomolar to micromolar concentrations...
March 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
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