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https://www.readbyqxmd.com/read/27923046/mitochondria-and-caspases-tune-nmnat-mediated-stabilization-to-promote-axon-regeneration
#1
Li Chen, Derek M Nye, Michelle C Stone, Alexis T Weiner, Kyle W Gheres, Xin Xiong, Catherine A Collins, Melissa M Rolls
Axon injury can lead to several cell survival responses including increased stability and axon regeneration. Using an accessible Drosophila model system, we investigated the regulation of injury responses and their relationship. Axon injury stabilizes the rest of the cell, including the entire dendrite arbor. After axon injury we found mitochondrial fission in dendrites was upregulated, and that reducing fission increased stabilization or neuroprotection (NP). Thus axon injury seems to both turn on NP, but also dampen it by activating mitochondrial fission...
December 6, 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27923008/a-framework-for-health-communication-across-the-hiv-treatment-continuum
#2
Stella Babalola, Lynn M Van Lith, Elizabeth C Mallalieu, Zoe R Packman, Emily Myers, Kim Seifert Ahanda, Emily Harris, Tilly Gurman, Maria-Elena Figueroa
BACKGROUND: As test and treat rolls out, effective interventions are needed to address the determinants of outcomes across the HIV treatment continuum and ensure that people infected with HIV are promptly tested, initiate treatment early, adhere to treatment, and are virally suppressed. Communication approaches offer viable options for promoting relevant behaviors across the continuum. CONCEPTUAL FRAMEWORK: This article introduces a conceptual framework, which can guide the development of effective health communication interventions and activities that aim to impact behaviors across the HIV treatment continuum in low- and medium-income countries...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27922871/excellent-response-to-177lu-psma-617-radioligand-therapy-in-a-patient-with-advanced-metastatic-castration-resistant-prostate-cancer-evaluated-by-68ga-psma-pet-ct
#3
Wolfgang Roll, Axel Bode, Matthias Weckesser, Martin Bögemann, Kambiz Rahbar
Recently radiolabeled ligands targeting prostate specific membrane antigen (PSMA) have been introduced for diagnostics and treatment of prostate cancer. Labeled with Lutetium, PSMA radioligand therapy (RLT) is one of the most promising new treatments of metastatic castration refractory prostate cancer. We present images of Ga-PSMA PET/CT and parameters of response of a 75-year-old heavily pretreated metastatic castration refractory prostate cancer patient with extended bone metastases, showing an extraordinary biochemical response in PSA-levels concordant to SUV decline in bone metastases...
December 3, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27921118/can-different-occlusal-positions-instantaneously-impact-spine-and-body-posture-a-pilot-study-using-rasterstereography-for-a-three-dimensional-evaluation
#4
Karoline März, Werner Adler, Ragai-Edward Matta, Linda Wolf, Manfred Wichmann, Bastian Bergauer
PURPOSE: Orthodontists influence dental occlusion directly. To suggest any link between dental occlusion and body posture is highly contentious, as evidenced by the literature. Rasterstereography, an optical technique that enables three-dimensional (3D) body measurements to be collected, has not yet been used to impartially examine whether different occlusal positions could instantaneously alter spine and body posture. We therefore set out to use this technique to nonsubjectively evaluate this question under static conditions...
December 5, 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27919584/assessment-of-population-exposure-to-pm2-5-for-mortality-in-china-and-its-public-health-benefit-based-on-benmap
#5
Li Chen, Mengshuang Shi, Shuang Gao, Suhuan Li, Jian Mao, Hui Zhang, Yanling Sun, Zhipeng Bai, Zhongliang Wang
Along with the rapid socioeconomic development, air pollution in China has become a severe problem. One component of air pollution, in particular, PM2.5 has aroused wide public concern because of its high concentration. In this study, data were collected from over 900 monitoring sites of the newly constructed PM2.5 monitoring network in China. The interpolation methods were used to simulate the PM2.5 exposure level of China especially in rural areas, thus reflecting the spatial variation of PM2.5 pollution...
December 2, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27919397/a-national-standards-based-assessment-on-functionality-of-electronic-medical-records-systems-used-in-kenyan-public-sector-health-facilities
#6
REVIEW
Samuel Kang'a, Nancy Puttkammer, Steven Wanyee, Davies Kimanga, Jason Madrano, Veronica Muthee, Patrick Odawo, Anjali Sharma, Tom Oluoch, Katherine Robinson, James Kwach, William B Lober
BACKGROUND: Variations in the functionality, content and form of electronic medical record systems (EMRs) challenge national roll-out of these systems as part of a national strategy to monitor HIV response. To enforce the EMRs minimum requirements for delivery of quality HIV services, the Kenya Ministry of Health (MoH) developed EMRs standards and guidelines. The standards guided the recommendation of EMRs that met a preset threshold for national roll-out. METHODS: Using a standards-based checklist, six review teams formed by the MoH EMRs Technical Working Group rated a total of 17 unique EMRs in 28 heath facilities selected by individual owners for their optimal EMR implementation...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27918659/importance-of-various-training-load-measures-on-injury-incidence-of-professional-rugby-league-athletes
#7
Heidi R Thornton, Jace A Delaney, Grant M Duthie, Ben J Dascombe
PURPOSE: To investigate the ability of various internal and external training load (TL) monitoring measures to predict injury incidence amongst positional groups within professional rugby league athletes. METHODS: TL and injury data were collected across 3 seasons (2013-2015) from twenty-five players competing in the National Rugby League competition. Daily TL data were included in the analysis, including session rating of perceived exertion (sRPE-TL), total distance (TD), high-speed running distance (HSD; >5m·s(-1)) and high-metabolic power distance (HPD; >20 W·kg(-1))...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27918655/activity-profiles-and-positional-differences-of-handball-players-during-the-world-championships-in-qatar-2015
#8
Marco Cardinale, Rodney Whiteley, Ahmed Abdelrahman Hosny, Nebojsa Popovic
PURPOSE: Handball is an Olympic sport played indoor by 6 court players and one goalkeeper with rolling substitutions. Limited data exist on elite players competing in a World Championship and virtually no information exits on the evolution of time-motion performance over the course of a long tournament. Therefore, the aim of this study was to analyze time motion characteristics of elite male handball players of the last World Championships played in Qatar in 2015. METHODS: 384 Players from 24 national teams were analyzed during 88 matches using a tracking camera system and a bespoke software (Prozone Handball V...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27918651/rational-design-of-high-performance-wide-bandgap-%C3%A2-2-ev-polymer-semiconductors-as-electron-donors-in-organic-photovoltaics-exhibiting-high-open-circuit-voltages-%C3%A2-1-v
#9
Christos L Chochos, Athanasios Katsouras, Nicola Gasparini, Chrysanthos Koulogiannis, Tayebeh Ameri, Christoph J Brabec, Apostolos Avgeropoulos
Systematic optimization of the chemical structure of wide-bandgap (≈2.0 eV) "donor-acceptor" copolymers consisting of indacenodithiophene or indacenodithieno[3,2-b]thiophene as the electron-rich unit and thieno[3,4-c]pyrrole-4,6-dione as the electron-deficient moiety in terms of alkyl side chain engineering and distance of the electron-rich and electron-deficient monomers within the repeat unit of the polymer chain results in high-performance electron donor materials for organic photovoltaics. Specifically, preliminary results demonstrate extremely high open circuit voltages (V oc s) of ≈1...
December 5, 2016: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/27917923/revealing-extraordinary-tensile-plasticity-in-layered-ti-al-metal-composite
#10
M Huang, G H Fan, L Geng, G J Cao, Y Du, H Wu, T T Zhang, H J Kang, T M Wang, G H Du, H L Xie
Layered Ti-Al metal composite (LMC) fabricated by hot-pressing and hot-rolling process displays higher ductility than that of both components. In this paper, a combination of digital image correlation (DIC) and X-ray tomography revealed that strain delocalization and constrained crack distribution are the origin of extraordinary tensile ductility. Strain delocalization was derived from the transfer of strain partitioning between Ti and Al layer, which relieved effectively the strain localization of LMC. Furthermore, the extensive cracks of LMC were restricted in the interface due to constraint effect...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917900/self-cleaning-of-surfaces-the-role-of-surface-wettability-and-dust-types
#11
Yun-Yun Quan, Li-Zhi Zhang, Rong-Hui Qi, Rong-Rong Cai
The self-cleaning property is usually connected to superhydrophobic surfaces (SHSs) where the dust particles can be easily removed by the rolling motion of droplets. It seems that superhydrophobicity (its durability is questionable nowadays) is a necessity. However here, it is disclosed that self-cleaning can also be realized on an ordinary surface by droplet impinging. The effects of surface wettability and the types of dust particles are considered. The self-cleaning is realized by two steps: (1) the pickup of particles by the water-air interface of an impinging droplet, (2) the release of the impinging droplets from the surface...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27915180/self-primed-isothermal-amplification-for-genomic-dna-detection-of-human-papillomavirus
#12
Wei Lu, Qingpan Yuan, Zhiliu Yang, Bo Yao
Rolling circle amplification (RCA) is an isothermal amplification technique with high efficiency and perfect accuracy for nucleic acids detection. However, RCA technique suffers the limitation to detect short DNA or RNA molecules. For long nucleic acid molecules, enzymatic restriction as well as heat denaturation process is usually required, which makes the amplification not effective and strictly isothermal. In this article, a simple and efficient one-pot self-primed isothermal amplification (SIA) was developed for detection of genomic DNA directly based on the combination of nicking endonuclease assisted strand displacement amplification (SDA) and exponential RCA...
October 10, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27911915/marathon-race-affects-neutrophil-surface-molecules-role-of-inflammatory-mediators
#13
Vinicius Coneglian Santos, Ana Paula Renno Sierra, Rodrigo Oliveira, Kim Guimarães Caçula, César Miguel Momesso, Fabio Takeo Sato, Maysa Braga Barros Silva, Heloisa Helena Oliveira, Maria Elizabeth Pereira Passos, Diego Ribeiro de Souza, Olivia Santos Gondim, Marino Benetti, Adriana Cristina Levada-Pires, Nabil Ghorayeb, Maria Augusta Peduti Dal Molin Kiss, Renata Gorjão, Tânia Cristina Pithon-Curi, Maria Fernanda Cury-Boaventura
The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was to investigate the effect of marathon races on surface molecules related to neutrophil adhesion and extrinsic apoptosis pathway and its association with inflammatory markers. We evaluated 23 trained male runners at the São Paulo International Marathon 2013...
2016: PloS One
https://www.readbyqxmd.com/read/27911898/bilaterian-giant-ankyrins-have-a-common-evolutionary-origin-and-play-a-conserved-role-in-patterning-the-axon-initial-segment
#14
Timothy Jegla, Michelle M Nguyen, Chengye Feng, Daniel J Goetschius, Esteban Luna, Damian B van Rossum, Bishoy Kamel, Aditya Pisupati, Elliott S Milner, Melissa M Rolls
In vertebrate neurons, the axon initial segment (AIS) is specialized for action potential initiation. It is organized by a giant 480 Kd variant of ankyrin G (AnkG) that serves as an anchor for ion channels and is required for a plasma membrane diffusion barrier that excludes somatodendritic proteins from the axon. An unusually long exon required to encode this 480Kd variant is thought to have been inserted only recently during vertebrate evolution, so the giant ankyrin-based AIS scaffold has been viewed as a vertebrate adaptation for fast, precise signaling...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27911755/transformation-of-vestibular-signals-for-the-control-of-standing-in-humans
#15
Patrick A Forbes, Billy L Luu, H F Machiel Van der Loos, Elizabeth A Croft, J Timothy Inglis, Jean-Sébastien Blouin
: During standing balance, vestibular signals encode head movement and are transformed into coordinates that are relevant to maintaining upright posture of the whole body. This transformation must account for head-on-body orientation as well as the muscle actions generating the postural response. Here, we investigate whether this transformation is dependent upon a muscle's ability to stabilize the body along the direction of a vestibular disturbance. Subjects were braced on top of a robotic balance system that simulated the mechanics of standing while being exposed to an electrical vestibular stimulus that evoked a craniocentric vestibular error of head roll...
November 9, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27911652/trueness-and-minimal-detectable-change-of-smartphone-inclinometer-measurements-of-shoulder-range-of-motion
#16
Patrick Boissy, Serigne Diop-Fallou, Karina Lebel, Mikael Bernier, Frederic Balg, Yanick Tousignant-Laflamme
BACKGROUND: Digital inclinometer applications using data from embedded sensors on smartphone/multi-purpose pocket computers or "smart digital inclinometers" (SDIs) are now used to clinically assess range of motion (ROM). OBJECTIVES: The objectives of this study were to assess, compared with a biomechanical gold standard (GS), the trueness and minimal detectable change (MDC) of shoulder range of motion (SROM) measurements obtained from an SDI. METHODS: Twenty-five (n = 25) asymptomatic healthy participants performed three trials of shoulder flexion (SF), shoulder abduction (SA), and shoulder external rotation (SER) at full-range and mid-range...
December 2, 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/27911492/rolling-circle-amplification-with-chemically-modified-nucleoside-triphosphates
#17
Marcel Hollenstein, Masad J Damha
Modified nucleoside triphosphates (dN*TPs) represent facile and versatile precursors for the introduction of chemical diversity into nucleic acids. While dN*TPs have been utilized in a plethora of practical applications, very little attention has been devoted to the assessment of their compatibility with isothermal amplification strategies. In this context, rolling circle amplification (RCA) is a wide-spread enzymatic replication method in which small single-stranded DNA (ssDNA) circles serve as templates in primer extension reactions yielding very long, ssDNA products...
December 1, 2016: Current Protocols in Nucleic Acid Chemistry
https://www.readbyqxmd.com/read/27910943/identification-of-absolute-geometries-of-cis-and-trans-molecular-isomers-by-coulomb-explosion-imaging
#18
Utuq Ablikim, Cédric Bomme, Hui Xiong, Evgeny Savelyev, Razib Obaid, Balram Kaderiya, Sven Augustin, Kirsten Schnorr, Ileana Dumitriu, Timur Osipov, René Bilodeau, David Kilcoyne, Vinod Kumarappan, Artem Rudenko, Nora Berrah, Daniel Rolles
An experimental route to identify and separate geometric isomers by means of coincident Coulomb explosion imaging is presented, allowing isomer-resolved photoionization studies on isomerically mixed samples. We demonstrate the technique on cis/trans 1,2-dibromoethene (C2H2Br2). The momentum correlation between the bromine ions in a three-body fragmentation process induced by bromine 3d inner-shell photoionization is used to identify the cis and trans structures of the isomers. The experimentally determined momentum correlations and the isomer-resolved fragment-ion kinetic energies are matched closely by a classical Coulomb explosion model...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910139/characterization-of-patients-with-chronic-pulmonary-aspergillosis-according-to-the-new-escmid-ers-ecmm-and-idsa-guidelines
#19
Helmut J F Salzer, Jan Heyckendorf, Barbara Kalsdorf, Thierry Rolling, Christoph Lange
Recently, the Infectious Diseases Society of America (IDSA) and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) in cooperation with the European Respiratory Society (ERS) and the European Confederation of Medical Mycology (ECMM) published guidelines for the diagnosis of chronic pulmonary aspergillosis (CPA). Both guidelines, however, carry significant differences. We retrospectively applied the diagnostic recommendations on a patient cohort of 71 previously diagnosed CPA patients in order to compare both guidelines...
December 1, 2016: Mycoses
https://www.readbyqxmd.com/read/27908502/centralized-capacity-building-training-of-lichtenstein-hernioplasty-in-brazil
#20
Alexandra M Moore, Néha Datta, Justin P Wagner, Alexander D Schroeder, Wolfgang Reinpold, Maurice Y Franciss, Rodrigo A Silva, David C Chen, Charles J Filipi, Sergio Roll
BACKGROUND: In Brazil, access to healthcare varies widely by community. Options for repair of surgically correctable conditions, such as inguinal hernias, are limited. A training program was instituted to expand access to Lichtenstein hernioplasty. METHODS: Between September, 2014 and September, 2015, 3 orders of training series took place in São Paulo, Brazil. Participating surgeons received training and assessments from expert trainers using the Operative Performance Rating Scale (OPRS)...
November 22, 2016: American Journal of Surgery
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