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https://www.readbyqxmd.com/read/29333658/in-situ-shrna-synthesis-on-dna-polylactide-nanoparticles-to-treat-multidrug-resistant-breast-cancer
#1
Qianqian Ni, Fuwu Zhang, Yunlei Zhang, Guizhi Zhu, Zhe Wang, Zhaogang Teng, Chunyan Wang, Bryant C Yung, Gang Niu, Guangming Lu, Longjiang Zhang, Xiaoyuan Chen
Nanomedicine has shown unprecedented potential for cancer theranostics. Nucleic acid (e.g., DNA and RNA) nanomedicines are of particular interest for combination therapy with chemotherapeutics. However, current nanotechnologies to construct such nucleic acid nanomedicines, which rely on chemical conjugation or physical complexation of nucleic acids with chemotherapeutics, have restrained their clinical translation due to limitations such as low drug loading efficiency and poor biostability. Herein, in situ rolling circle transcription (RCT) is applied to synthesize short hairpin RNA (shRNA) on amphiphilic DNA-polylactide (PLA) micelles...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333462/assessment-of-ultrasound-radio-guided-occult-lesion-localization-in-non-palpable-breast-lesions
#2
Seyed Ali Alamdaran, Donia Farokh, Ayda Sharifi Haddad, Navid Daghighi, Elaheh Modoodi, Ramin Sadeghi, Mohammad Naser Forghani, Asieh Sadat Fattahi
Objectives: Controversy exists about the localization of non-palpable breast lesions. In many countries, the gold standard for the diagnosis of these lesions is needle localization due to its accuracy. This study sought to compare the ultrasound- and radio-guided occult lesion localization (ROLL) as a simple method with the conventional procedures in terms of their diagnostic power. Methods: This study was conducted on 94 patients with non-palpable breast lesions detected by ultrasonography and localized by the combination of ultrasonography and using radiopharmaceuticals...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29331434/fault-diagnosis-of-rolling-element-bearing-using-a-new-optimal-scale-morphology-analysis-method
#3
Xiaoan Yan, Minping Jia, Wan Zhang, Lin Zhu
Periodic transient impulses are key indicators of rolling element bearing defects. Efficient acquisition of impact impulses concerned with the defects is of much concern to the precise detection of bearing defects. However, transient features of rolling element bearing are generally immersed in stochastic noise and harmonic interference. Therefore, in this paper, a new optimal scale morphology analysis method, named adaptive multiscale combination morphological filter-hat transform (AMCMFH), is proposed for rolling element bearing fault diagnosis, which can both reduce stochastic noise and reserve signal details...
January 10, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29331210/to-roll-the-eyes-and-snap-a-bite-function-development-and-evolution-of-craniofacial-muscles
#4
REVIEW
Frank R Schubert, Arun J Singh, Oluwatomisin Afoyalan, Chrissa Kioussi, Susanne Dietrich
Craniofacial muscles, muscles that move the eyes, control facial expression and allow food uptake and speech, have long been regarded as a variation on the general body muscle scheme. However, evidence has accumulated that the function of head muscles, their developmental anatomy and the underlying regulatory cascades are distinct. This article reviews the key aspects of craniofacial muscle and muscle stem cell formation and discusses how this differs from the trunk programme of myogenesis; we show novel RNAseq data to support this notion...
January 10, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29331054/artist-a-fully-automated-artifact-rejection-algorithm-for-single-pulse-tms-eeg-data
#5
Wei Wu, Corey J Keller, Nigel C Rogasch, Parker Longwell, Emmanuel Shpigel, Camarin E Rolle, Amit Etkin
Concurrent single-pulse TMS-EEG (spTMS-EEG) is an emerging noninvasive tool for probing causal brain dynamics in humans. However, in addition to the common artifacts in standard EEG data, spTMS-EEG data suffer from enormous stimulation-induced artifacts, posing significant challenges to the extraction of neural information. Typically, neural signals are analyzed after a manual time-intensive and often subjective process of artifact rejection. Here we describe a fully automated algorithm for spTMS-EEG artifact rejection...
January 13, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29328122/model-assisted-measuring-method-for-periodical-sub-wavelength-nanostructures
#6
Gabriela Alexe, Andreas Tausendfreund, Dirk Stöbener, Andreas Fischer
This paper describes a scatterometry approach designed by simulations for the in-line characterization of sub-wavelength sinusoidal gratings, which are formed on a transparent foil in a roll-to-roll procedure. Currently used methods are based on series of in situ measurements of the specular optical response at different incident angles or wavelengths for acquiring dimensional information on the gratings. The capability of single measurements of the first diffraction maxima at a fixed incident angle and wavelength to accurately measure the height of the sub-wavelength sinusoidal gratings is investigated in this work...
January 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29328060/-i-in-vivo-i-neutron-activation-analysis-of-bone-manganese-in-workers
#7
Yingzi Liu, Danelle Rolle-McFarland, Farshad Mostafaei, Yuanzhong Zhou, Yan Li, Wei Zheng, Ellen Wells, Linda Huiling Nie
Manganese (Mn) is a neurotoxicant. However, the impact of elevated, chronic Mn exposure is not well understood, partially due to the lack of a cumulative exposure biomarker. To address this gap, our group developed a compact <i>in vivo</i> neutron activation analysis (IVNAA) system to quantify Mn in bone (MnBn). In this study, we used this system and determined MnBn among male Chinese workers and compared results to their blood Mn (MnB), a measure of recent exposure, and the years of employment, a measure of cumulative exposure...
January 12, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29327630/the-specter-of-the-primitive
#8
Gregory S Rizzolo
Traditional psychoanalytic theories of development hold that the adult neurotic can regress, or has already regressed, to the childhood arrests and/or fixations in which his pathology originated. More recent critiques have called this possibility into question. It is unlikely that anyone can roll back the additions and modifications of lifespan development in a full-fledged return to the needs, wishes, and anxieties of childhood. By regression, though, some analysts mean not a full-fledged return to an earlier developmental phase, but a non-phase-specific slip into primitive fantasies and defenses...
December 2017: Journal of the American Psychoanalytic Association
https://www.readbyqxmd.com/read/29327571/recent-developments-in-vascular-robotics
#9
Alexander E Rolls, Colin D Bicknell, Nicholas J Cheshire, Mohamad Hamady, Celia V Riga
No abstract text is available yet for this article.
January 9, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29327520/risk-factors-of-clinical-and-immunological-failure-in-south-indian-cohort-on-generic-antiretroviral-therapy
#10
Mucheli Shravan Sadashiv, Priscilla Rupali, Abi Manesh, Rajesh Kannangai, Ooriapadickal Cherian Abraham, Susanne A Pulimood, Rajiv Karthik, S Rajkumar, Kurien Thomas
Background: Since the time of NACO Antiretroviral (ART) roll-out, generic ART has been the mainstay of therapy. There are many studies documenting the efficacy of generic ART but with the passage of time, failure of therapy is on the rise. As institution of second line ART has significant financial implications both for a program and for an individual it is imperative that we determine factors which contribute towards treatment failure in a cohort of patients on generic antiretroviral therapy...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29326327/national-roll-out-of-latent-tuberculosis-testing-and-treatment-for-new-migrants-in-england-a-retrospective-evaluation-in-a-high-incidence-area
#11
Miranda G Loutet, Matthew Burman, Nivenka Jayasekera, Duncan Trathen, Susan Dart, Heinke Kunst, Dominik Zenner
Latent tuberculosis infection (LTBI) screening is an important intervention for tuberculosis (TB) elimination in low-incidence countries and is, therefore, a key component of England's TB control strategy. This study describes outcomes from a LTBI screening programme in a high-incidence area to inform national LTBI screening in England and other low-incidence countries.We conducted a retrospective cohort study of LTBI screening among eligible migrants (from high-incidence countries and entered the UK within the last 5 years), who were identified at primary-care clinics in Newham, London between August 2014 and August 2015...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29325490/allocating-less-attention-to-central-vision-during-vection-is-correlated-with-less-motion-sickness
#12
Yue Wei, Jiayue Zheng, Richard H Y So
Visually induced motion sickness (VIMS) is a common discomfort response associated with vection-provoking stimuli. It is suggested that VIMS susceptibility depends on the ability to regulate visual performance during vection. To test this, in total 29 participants, with VIMS susceptibility assessed by Motion Sickness Susceptibility Questionnaire, were recruited in three successive experiments to perform sustained attention to response tests (SARTs) while watching dot pattern stimuli known to provoke roll-vection...
January 11, 2018: Ergonomics
https://www.readbyqxmd.com/read/29324902/potential-impact-of-neonicotinoid-use-on-northern-bobwhite-colinus-virginianus-in-texas-a-historical-analysis
#13
Hannah M H Ertl, Miguel A Mora, Donald J Brightsmith, Jorge A Navarro-Alberto
The widespread use of neonicotinoid insecticides in recent years has led to increasing environmental concern, including impacts to avian populations. In Texas and across their range, Northern bobwhite (Colinus virginianus) habitat frequently overlaps cultivated cropland protected by neonicotinoids. To address the effects of neonicotinoid use on bobwhites in Texas, we conducted a historical analysis from 1978-2012 in Texas' ecological regions using quail count data collected from North American Breeding Bird Survey and Texas Parks and Wildlife Department, and neonicotinoid use data from the U...
2018: PloS One
https://www.readbyqxmd.com/read/29324806/immunocompetent-host-develops-mild-intestinal-inflammation-in-acute-infection-with-toxoplasma-gondii
#14
Paulo da Silva Watanabe, Aline Rosa Trevizan, Saulo Euclides Silva-Filho, Marcelo Biondaro Góis, João Luiz Garcia, Roberto Kenji Nakamura Cuman, Ana Cristina Breithaupt-Faloppa, Débora de Mello Gonçales Sant Ana, Gessilda de Alcantara Nogueira de Melo
Toxoplasma gondii (T. gondii) is the causative agent of toxoplasmosis, common zoonosis among vertebrates and high incidence worldwide. During the infection, the parasite needs to transpose the intestinal barrier to spread throughout the body, which may be a trigger for an inflammatory reaction. This work evaluated the inflammatory alterations of early T. gondii infection in peripheral blood cells, in the mesenteric microcirculation, and small intestinal tissue by measurement of MPO (myeloperoxidase) activity and NO (nitric oxide) level in rats...
2018: PloS One
https://www.readbyqxmd.com/read/29324732/tobacco-product-use-among-military-veterans-united-states-2010-2015
#15
Satomi Odani, Israel T Agaku, Corinne M Graffunder, Michael A Tynan, Brian S Armour
In 2015, an estimated 18.8 million U.S. adults were military veterans (1). Although the prevalence of tobacco-attributable conditions is high among veterans (2), there is a paucity of data on use of tobacco products, other than cigarettes, in this population. To monitor tobacco product use among veterans, CDC analyzed self-reported current (i.e., past 30-day) use of five tobacco product types (cigarettes, cigars [big cigars, cigarillos, or little cigars], roll-your-own tobacco, pipes, and smokeless tobacco [chewing tobacco, snuff, dip, or snus]) from the National Survey on Drug Use and Health (NSDUH)...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29323869/dual-functional-superhydrophobic-textile-with-asymmetric-roll-down-pinned-states-for-water-droplet-transportation-and-oil-water-separation
#16
Xiaojing Su, Hongqiang Li, Xuejun Lai, Lin Zhang, Xiaofeng Liao, Jing Wang, Zhonghua Chen, Jie He, Xingrong Zeng
Superhydrophobic surfaces with tunable adhesion from lotus-leaf to rose-petal states have aroused much attention for their potential applications in self-cleaning, anti-icing, oil-water separation, microdroplet transportation and microfluidic devices. Herein, we report a facile magnetic-field-manipulation strategy to fabricating dual-functional superhydrophobic textile with asymmetric roll-down/pinned states on the two surfaces of textile simultaneously. Upon exposure to a static magnetic field, fluoroalkylsilane modified iron oxide (F-Fe3O4) nanoparticles in polydimethylsiloxane (PDMS) moved along the magnetic field to construct discrepant hierarchical structures and roughnesses on the two sides of textile...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29322899/is-the-pelvis-stable-during-supine-total-hip-arthroplasty
#17
S M Shah, W L Walter, J Ngo
Intra- operative changes in pelvic position during total hip arthroplasty (THA) can affect acetabular orientation. We evaluated these changes during supine THA using a proprietary mobile application called PelvicTracker. Twenty- two patients undergoing THA using direct anterior approach were included in the study. In the sagittal plane, the pelvis was extended (anterior tilt) as compared to the start of surgery in 19/ 22 hips at the time of cup implantation (mean extension: 3.1°; range: 1°-6°). In the transverse plane, the pelvis was rolled to the opposite side of surgery in 12 hips (mean roll: 2...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29322578/the-different-outcomes-of-legislative-versus-advocacy-led-development-of-cannabis-policy
#18
Stephen Rolles
No abstract text is available yet for this article.
January 10, 2018: Addiction
https://www.readbyqxmd.com/read/29322521/fitting-unanchored-puzzle-pieces-in-the-skeleton-appropriate-3d-scapular-positions-for-the-quadrupedal-support-in-tetrapods
#19
Shin-Ichi Fujiwara
Deducing the scapular positions of extinct tetrapod skeletons remains difficult, because the scapulae and rib cage are connected with each other not directly by skeletal joint, but by thoracic muscles. In extant non-testudine quadrupedal tetrapods, the top positions of the scapulae/suprascapulae occur at the anterior portion of the rib cage, above the vertebral column and near the median plane. The adequacy of this position was tested using three-dimensional mechanical models of Felis, Rattus and Chamaeleo that assumed stances on a forelimb on a single side and the hindlimbs...
January 11, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29322054/spatial-distribution-of-medically-important-scorpions-in-north-west-of-iran
#20
Mulood Mohammadi Bavani, Javad Rafinejad, Ahmad Ali Hanafi-Bojd, Mohammad Ali Oshaghi, Shahrokh Navidpour, Farrokh Dabiri, Mehdi Badakhshan, Esmaeil Ghorbani, Masoomeh Bagheri
Background: Scorpions are one of the most important medical arthropods in Iran. This study aimed to determine the fauna, spatial distribution and some morphological characteristics of these venomous arthropods in the study area. Methods: Scorpions were collected using Ultra Violet light, rock rolling and digging methods in West Azerbaijan, East Azerbaijan, and Ardabil Provinces during 2015-2016. The specimens were preserved in 75% ethyl alcohol and transferred to the laboratory for species identification and morphological studies...
September 2017: Journal of Arthropod-borne Diseases
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