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Extravasation

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https://www.readbyqxmd.com/read/29452625/knowledge-regarding-noncytotoxic-medication-extravasation-among-registered-nurses-working-in-western-saudi-arabia
#1
Mo'men Sisan, Ahmad Rayan, Soha Elmorsy, Hamza Elyan, Mosab Salahat
Extravasation and infiltration are among the most common intravenous therapy complications. For noncytotoxic agents, the incidence of extravasation remains unknown. There has been little research into extravasation due to ethical considerations limiting controlled research; most evidences are based on small, uncontrolled trials or case reports. The purpose of this study was to assess the knowledge level regarding noncytotoxic medications extravasation and its associated factors among staff nurses.A descriptive correlational design using self-administered questionnaire was employed...
March 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29452577/polymerase-delta-interacting-protein-2-deficiency-protects-against-blood-brain-barrier-permeability-in-the-ischemic-brain
#2
Marina S Hernandes, Bernard Lassègue, Lula L Hilenski, Jonathan Adams, Ning Gao, Chia-Yi Kuan, Yu-Yo Sun, Lihong Cheng, Daniel S Kikuchi, Manuel Yepes, Kathy K Griendling
BACKGROUND: Polymerase δ-interacting protein 2 (Poldip2) is a multifunctional protein that regulates vascular extracellular matrix composition and matrix metalloproteinase (MMP) activity. The blood-brain barrier (BBB) is a dynamic system assembled by endothelial cells, basal lamina, and perivascular astrocytes, raising the possibility that Poldip2 may be involved in maintaining its structure. We investigated the role of Poldip2 in the late BBB permeability induced by cerebral ischemia...
February 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29451453/trapped-ventricle-after-laser-ablation-of-a-subependymal-giant-cell-astrocytoma-complicated-by-intraventricular-gadolinium-extravasation-case-report
#3
Michael Karsy, Daxa M Patel, Robert J Bollo
Magnetic resonance imaging-guided stereotactic laser ablation of intracranial targets, including brain tumors, has expanded dramatically over the past decade, but there have been few reports of complications, especially those occurring in a delayed fashion. Laser ablation of subependymal giant cell astrocytomas (SEGAs) is an attractive alternative to maintenance immunotherapy in some children with tuberous sclerosis complex (TSC); however, the effect of treatment on disease progression and the nature and frequency of potential complications remains largely unknown...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29448806/endovascular-treatment-for-the-control-of-active-vaginal-bleeding-from-uterine-cervical-cancer-treated-with-radiotherapy
#4
Cheng Shi Chen, Sohee Park, Ji Hoon Shin, Yasir Nouri, Jong-Woo Kim, Hyun-Ki Yoon, Gi-Young Ko
Background Endovascular treatment has become a significant therapeutic option for the management of intractable bleeding in gynecologic malignancies. However, the endovascular treatment types were almost never mentioned when active bleeding from different arteries was identified. Purpose To present angiographic details and evaluate clinical efficacy of endovascular treatments to control active vaginal bleeding in uterine cervical cancer patients treated with radiotherapy. Material and Methods In this retrospective study, six, consecutive cervical cancer patients treated with radiotherapy who underwent endovascular treatment for active vaginal bleeding were included...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29443052/intravital-microscopy-of-tumor-associated-vasculature-using-advanced-dorsal-skinfold-window-chambers-on-transgenic-fluorescent-mice
#5
Ann L B Seynhaeve, Timo L M Ten Hagen
Tumor and tumor vessel development, as well as tumor response to therapeutics, are highly dynamic biological processes. Histology provides static information and is often not sufficient for a correct interpretation. Intravital evaluation, in which a process is followed in time, provides extra and often unexpected information. With the creation of transgenic animals expressing cell-specific markers and live cell tracers, improvements to imaging equipment, and the development of several imaging chambers, intravital microscopy has become an important tool to better understand biological processes...
January 19, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29439317/lumbar-sympathectomy-reduces-vascular-permeability-possibly-through-decreased-adenosine-receptor-a2a-expression-in-the-hind-plantar-skin-of-rats
#6
Zhifang Zheng, Yishu Liu, Lulu Zhu, Jianbing Tang, Wenhua Huang, Biao Cheng
BACKGROUND: The effect of lumbar sympathectomy for the treatment of lower limb ischemia remains a matter of controversy. METHODS: Sprague-Dawley rats were subjected to lumbar sympathectomy, after which Evans blue dye was injected into the hind plantar skin. Extravasation of dye was measured and compared with rats undergoing sham operation. Hind plantar skin was processed for HE staining, immunohistochemistry, and Western blot. RESULTS: In sympathectomized rats, blue stained areas in hind plantar skin and concentrations of Evans blue were significantly less than that of sham sympathectomy (control) rats, both 2 weeks and 3 months after surgery...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29438223/knockdown-of-tfpi-anchored-endothelial-cells-exacerbates-lipopolysaccharide-induced-acute-lung-injury-via-nf-%C3%AE%C2%BAb-signaling-pathway
#7
Bao Q Wang, Meng Shi, Jian P Zhang, Xie Wu, Mei J Chang, Zhi H Chen, Hua H Shen, Yuan L Song, Jian Zhou, Chun X Bai
BACKGROUND: As activation of the coagulation system is both a consequence and contributor to acute lung injury (ALI), pulmonary coagulopathy has become a potential target for therapeutic intervention in ALI patients. We investigated the effects and possible mechanisms of endothelial cell (EC)-anchored tissue factor pathway inhibitor (TFPI) on lipopolysaccharide (LPS)-induced ALI in mice. METHODS: To assess the effect of endothelial cell-anchored TFPI deletion on ALI indices, TFPI knockout (cKO) mice were generated...
February 12, 2018: Shock
https://www.readbyqxmd.com/read/29438206/surgical-outcome-after-less-rigid-fixation-in-open-cranial-vault-remodeling-for-craniosynostosis
#8
Khai Luen Koh, Ali Zain
: Open cranial vault remodeling techniques require rigid fixation with hardware such as plates and screws; however, complications can occur. The purpose of this study was to assess the surgical outcome after open reconstruction for craniosynostosis with less rigid fixation using nonabsorbable suture. METHODS: Retrospective review of patients who underwent open craniofacial reconstruction for craniosynostosis at the Hospital Kuala Lumpur between January 2011 and December 2016 were performed...
February 12, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29435150/blood-brain-barrier-disruption-induced-by-diagnostic-ultrasound-combined-with-microbubbles-in-mice
#9
Bingxia Zhao, Yihan Chen, Jinfeng Liu, Li Zhang, Jing Wang, Yali Yang, Qing Lv, Mingxing Xie
Objective: To investigate the effects of the microbubble (MB) dose, mechanism index (MI) and sonication duration on blood-brain barrier (BBB) disruption induced by diagnostic ultrasound combined with MBs as well as to investigate the potential molecular mechanism. Results: The extent of BBB disruption increased with MB dose, MI and sonication duration. A relatively larger extent of BBB disruption associated with minimal tissue damage was achieved by an appropriate MB dose and ultrasound exposure parameters with diagnostic ultrasound...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29432823/mechanism-based-pharmacokinetic-mbpk-models-describe-the-complex-plasma-kinetics-of-three-antiretrovirals-delivered-by-a-long-acting-anti-hiv-drug-combination-nanoparticle-formulation
#10
John C Kraft, Lisa A McConnachie, Josefin Koehn, Loren Kinman, Jianguo Sun, Ann C Collier, Carol Collins, Danny D Shen, Rodney J Y Ho
Existing oral antiretroviral (ARV) agents have been shown in human studies to exhibit limited lymph node penetration and lymphatic drug insufficiency. As lymph nodes are a reservoir of HIV, it is critical to deliver and sustain effective levels of ARV combinations in these tissues. To overcome lymph node drug insufficiency of oral combination ARV therapy (cART), we developed and reported a long-acting and lymphocyte-targeting injectable that contains three ARVs-hydrophobic lopinavir (LPV) and ritonavir (RTV), and hydrophilic tenofovir (TFV)-stabilized by lipid excipients in a nanosuspension...
February 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29430449/new-insights-into-the-mechanisms-of-pulmonary-edema-in-acute-lung-injury
#11
REVIEW
Raquel Herrero, Gema Sanchez, Jose Angel Lorente
Appearance of alveolar protein-rich edema is an early event in the development of acute respiratory distress syndrome (ARDS). Alveolar edema in ARDS results from a significant increase in the permeability of the alveolar epithelial barrier, and represents one of the main factors that contribute to the hypoxemia in these patients. Damage of the alveolar epithelium is considered a major mechanism responsible for the increased pulmonary permeability, which results in edema fluid containing high concentrations of extravasated macromolecules in the alveoli...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29427752/diagnosis-and-treatment-efficacy-of-digital-subtraction-angiography-and-transcatheter-arterial-embolization-in-post-pancreatectomy-hemorrhage-a-single-center-retrospective-cohort-study
#12
Yuan Fang, Xu Han, Lingxiao Liu, Wenhui Lou
BACKGROUND: To evaluate the diagnostic and treatment efficacy of digital subtraction angiography (DSA), transcatheter arterial embolization (TAE) in post-pancreatectomy hemorrhage (PPH). MATERIALS AND METHODS: This is a single-center retrospective cohort study. Clinicopathological data of 23 patients with PPH from August 2009 to November 2016 were collected. We observed (1) DSA procedures and hemorrhagic sites (2) TAE: successful rate and complications (3) Follow-up...
February 7, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29425970/the-therapeutic-potential-of-cystathionine-gamma-lyase-in-temporomandibular-inflammation-induced-orofacial-hypernociception
#13
Bruna M Santos, Emanuela G Garattini, Luiz G S Branco, Christie R A Leite-Panissi, Glauce C Nascimento
Hydrogen sulfide (H2S) is an endogenous neuromodulator produced mainly by the enzyme cystathionine gamma-lyase (CSE) in peripheral tissues. A pronociceptive role of endogenously produced H2S has been previously reported by our group in a model of orofacial inflammatory pain. Using the established persistent orofacial pain rat model induced by complete Freund's adjuvant (CFA) injection into temporomandibular joint (TMJ), we have now investigated the putative role of endogenous H2S modulating hypernociceptive responses...
February 6, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29421924/a-13-year-old-presenting-with-recurrent-angioma-serpiginosum
#14
Michael Bishara, Michael Jiaravuthisan, Miriam Weinstein
BACKGROUND: Angioma serpiginosum (AS) is a rare vascular abnormality consisting of proliferation and dilation of superficial blood vessels in the skin. AS typically presents in the first 2 decades of life and remains stable with time. CASE SUMMARY: We report the case of a 13-year-old female with an acquired, recurrent erythematous lesion with serpiginous borders on her left upper arm. Over several years, the lesion reappeared then disappeared 12 to 15 times. At one point, she developed a tender red nodule within the lesion; consequently, a biopsy was taken, revealing dilated telangiectatic vessels in the dermal papillae with mild, focal extravasation of erythrocytes...
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29415483/integrins-in-t-cell-physiology
#15
REVIEW
Alessandra Bertoni, Oscar Alabiso, Alessandra Silvia Galetto, Gianluca Baldanzi
From the thymus to the peripheral lymph nodes, integrin-mediated interactions with neighbor cells and the extracellular matrix tune T cell behavior by organizing cytoskeletal remodeling and modulating receptor signaling. LFA-1 (αLβ2 integrin) and VLA-4 (α4β1 integrin) play a key role throughout the T cell lifecycle from thymocyte differentiation to lymphocyte extravasation and finally play a fundamental role in organizing immune synapse, providing an essential costimulatory signal for the T cell receptor...
February 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29409382/distal-placement-of-resuscitative-endovascular-balloon-occlusion-of-the-aorta-reboa-to-restore-hemodynamic-stability-in-a-patient-with-proximal-aortic-rupture
#16
Shira Strauss, Paul Engels, John Harlock
PURPOSE: To report unconventional use of the resuscitative endovascular balloon occlusion of the aorta (REBOA) technique to restore hemodynamic stability in a patient who was hemorrhaging from aortic injury proximal to the target zone of occlusion. CASE REPORT: A 72-year-old woman underwent urgent thoracic stent-graft repair of a ruptured 8×8-cm mycotic pseudoaneurysm. Two months later, follow-up imaging revealed that the proximal aortic stent seal zone had degenerated, so a percutaneous procedure was performed 2 months later to preemptively reinforce the segment of stented aorta...
February 1, 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29405183/-the-forensic-medical-evaluation-of-the-injuries-inflicted-inside-the-passenger-compartment-of-a-moving-car-equipped-with-the-modern-personal-safety-systems
#17
Yu I Pigolkin, I A Dubrovin, A S Mosoyan, A A Bychkov
The objective of the present study was to elucidate the characteristic features of the injuries inflicted to the victims of a road traffic accident inside the passenger compartment of a moving car equipped with the modern personal safety systems. The materials available for the present work included the lesions documented in 210 drivers and 150 occupants of the car passenger compartments. Both comparative, morphometric and statistical methods were used to analyze the data obtained. The morphometric analysis included identification of the form of the injury, such as extravasation, wounds, fractures, and lesions of the internal organs (e...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29402939/p38-activation-induces-production-of-mir-146a-and-mir-31-to-repress-e-selectin-expression-and-inhibit-transendothelial-migration-of-colon-cancer-cells
#18
Liang Zhong, Jacques Huot, Martin J Simard
Extravasation of circulating cancer cells determines their metastatic potential. This process is initiated by the adhesion of cancer cells to vascular endothelial cells through specific interactions between endothelial adhesion receptors such as E-selectin and their ligands on cancer cells. In the present study, we show that miR-146a and miR-181b impede the expression of E-selectin by repressing the activity of its transcription factor NF-κB, thereby impairing the metastatic potentials of colon cancer cells by decreasing their adhesion to, and migration through, the endothelium...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29402847/extravascular-cd3-t-cells-in-brains-of-alzheimer-disease-patients-correlate-with-tau-but-not-with-amyloid-pathology-an-immunohistochemical-study
#19
Mario Merlini, Tunahan Kirabali, Luka Kulic, Roger M Nitsch, Maria Teresa Ferretti
BACKGROUND: Strong genetic and epidemiological evidence points to a crucial role of the immune system in the development of Alzheimer disease (AD). CD3+ T lymphocytes have been described in brains of postmortem AD patients and in transgenic models of AD-like cerebral amyloidosis and tau pathology. However, the occurrence of T cells in AD brains is still controversial; furthermore, the relationship between T cells and hallmarks of AD pathology (amyloid plaques and neurofibrillary tangles) remains to be established...
February 7, 2018: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29402157/alternative-approaches-to-surgical-hemostasis-in-patients-with-morbidly-adherent-placenta-undergoing-fertility-sparing-surgery
#20
Roman G Shmakov, Aleksandr A Vinitskiy, Vladimir D Chuprinin, Ekaterina L Yarotskaya, Gennady T Sukhikh
AIM: To evaluate the efficacy of different methods of surgical hemostasis, including the ligation of internal iliac arteries (IIA), temporary occlusion of the common iliac artery (CIA) and combined compression hemostasis, during cesarean section in patients with morbidly adherent placenta (MAP). MATERIALS AND METHODS: The study included 54 patients with MAP. All patients underwent cesarean section with application of surgical hemostasis techniques. In Group 1 (n = 15), ligation of IIA was performed, in Group 2 (n = 18) extravasal temporary occlusion of CIA, and in Group 3 (n = 21) combined compression hemostasis was applied...
February 5, 2018: Journal of Maternal-fetal & Neonatal Medicine
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