keyword
https://read.qxmd.com/read/38536827/effects-of-aflibercept-and-bevacizumab-on-cell-viability-cell-metabolism-and-inflammation-in-hypoxic-human-m%C3%A3-ller-cells
#1
JOURNAL ARTICLE
Monique Matsuda, Rafael André da Silva, Vinicius Moraes de Paiva Roda, Mônica Valéria Marquezini, Mário Luiz Ribeiro Monteiro, Dânia Emi Hamassaki
Anti-VEGF (vascular endothelial growth factor) drugs such as aflibercept (AFL) and bevacizumab (BVZ) inhibit pathological neo-angiogenesis and vascular permeability in retinal vascular diseases. As cytokines and growth factors are produced by Müller glial cells under stressful and pathological conditions, we evaluated the in vitro effect of AFL (Eylea®, 0.5 mg/mL) and BVZ (Avastin®, 0.5 mg/mL) on cell viability/metabolism, and cytokine/growth factor production by Müller cells (MIO-M1) under cobalt chloride (CoCl2)-induced hypoxia after 24h, 48h and 72h...
2024: PloS One
https://read.qxmd.com/read/38536776/electroacupuncture-stimulation-enhances-the-permeability-of-the-blood-brain-barrier-a-systematic-review-and-meta-analysis-of-preclinical-evidence-and-possible-mechanisms
#2
JOURNAL ARTICLE
Nuo Xu, Peng Gong, Shiting Xu, Yangyun Chen, Mengyuan Dai, Zhaoxing Jia, Xianming Lin
An important cellular barrier to maintain the stability of the brain's internal and external environment is the blood-brain barrier (BBB). It also prevents harmful substances from entering brain tissue through blood circulation while providing protection for the central nervous system. It should be noted, however, that the intact BBB can be a barrier to the transport of most drugs into the brain via the conventional route of administration, which can prevent them from reaching effective concentrations for the treatment of disorders affecting the central nervous system...
2024: PloS One
https://read.qxmd.com/read/38530908/adiponectin-reduces-glomerular-endothelial-glycocalyx-disruption-and-restores-glomerular-barrier-function-in-a-mouse-model-of-type-2-diabetes
#3
JOURNAL ARTICLE
Sarah Fawaz, Aldara Martin Alonso, Yan Qiu, Raina Ramnath, Holly Stowell-Connolly, Monica Gamez, Carl May, Colin Down, Richard J Coward, Matthew J Butler, Gavin I Welsh, Simon C Satchell, Rebecca R Foster
Adiponectin has vascular anti-inflammatory and protective effects. Whilst adiponectin is known to protect against the development of albuminuria, historically the focus has been on podocyte protection within the glomerular filtration barrier (GFB). The first barrier to albumin in the GFB is the endothelial glycocalyx (eGlx), a surface gel-like barrier covering glomerular endothelial cells (GEnC). In diabetes, eGlx dysfunction occurs before podocyte damage, hence we hypothesized that adiponectin could protect from eGlx damage to prevent early vascular damage in diabetic kidney disease (DKD)...
March 26, 2024: Diabetes
https://read.qxmd.com/read/38529560/janus-adhesive-microneedle-patch-loaded-with-exosomes-for-intrauterine-adhesion-treatment
#4
JOURNAL ARTICLE
Huihui Wang, Weijia Chen, Yuanhua Liu, Yuanchao Zhu, Yinan Huang, Zongxuan Lu
Intrauterine adhesions (IUAs) are common sequelae of cervical mucosa damage caused by uterine curettage. Establishing an anti-adhesion barrier between the damaged endometrium with a sustained-release drug capability and hence promoting endogenous regeneration of the endometrium is an available treatment for IUA. However, current therapy lacks long-term intracavitary residence, drug-delivery permeability, and tissue anti-adhesion to the endometrium. Here, we report the design of a Janus microneedle patch consisting of two layers: an adhesive inner layer with an exosomes-loaded microneedle, which endows the patch with a tissue adhesive capability as well as transdermal drug-delivery capability; and an anti-adhesion outer layer, which prevents the intrauterine membrane from postoperative adhesion...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38528077/nuciferine-reduces-vascular-leakage-and-improves-cardiac-function-in-acute-myocardial-infarction-by-regulating-the-pi3k-akt-pathway
#5
JOURNAL ARTICLE
Wei Xie, Shumin Chen, Wenzhe Wang, Xichun Qin, Chuiyu Kong, Dongjin Wang
The destruction of the microvascular structure and function can seriously affect the survival and prognosis of patients with acute myocardial infarction (AMI). Nuciferine has a potentially beneficial effect in the treatment of cardiovascular disease, albeit its role in microvascular structure and function during AMI remains unclear. This study aimed to investigate the protective effect and the related mechanisms of nuciferine in microvascular injury during AMI. Cardiac functions and pathological examination were conducted in vivo to investigate the effect of nuciferine on AMI...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38527519/long-term-outcomes-of-the-gore-excluder-low-permeability-endoprosthesis-for-the-treatment-of-infrarenal-aortic-aneurysms
#6
JOURNAL ARTICLE
Stefan P M Smorenburg, Jorg L de Bruin, Clark J Zeebregts, Michel M P J Reijnen, Hence J M Verhagen, Jan M M Heyligers
OBJECTIVE: This study evaluated the long term outcomes of endovascular aneurysm repair using the Gore Excluder Low Permeability (LP) endoprosthesis across high volume Dutch hospitals. METHODS: A retrospective analysis was conducted of patients treated with the Excluder LP for infrarenal abdominal aortic aneurysm (AAA) in four hospitals between 2004 - 2017. Primary outcomes were overall survival, freedom from re-interventions (overall, inside/outside instructions for use, IFU), and AAA sac dynamics: growth (> 5 mm), stabilisation, and regression (< 5 mm)...
March 23, 2024: European Journal of Vascular and Endovascular Surgery
https://read.qxmd.com/read/38522568/which-endovascular-aneurysm-repair-graft-should-i-have
#7
JOURNAL ARTICLE
Anantha Narayanan, Manar Khashram
No abstract text is available yet for this article.
March 22, 2024: European Journal of Vascular and Endovascular Surgery
https://read.qxmd.com/read/38522129/a-reverse-translational-approach-reveals-the-protective-roles-of-mangifera-indica-in-inflammatory-bowel-disease
#8
JOURNAL ARTICLE
Anella Saviano, Anna Schettino, Nunzia Iaccarino, Adel Abo Mansour, Jenefa Begum, Noemi Marigliano, Federica Raucci, Francesca Romano, Gelsomina Riccardi, Emma Mitidieri, Roberta d'Emmanuele di Villa Bianca, Ivana Bello, Elisabetta Panza, Martina Smimmo, Valentina Vellecco, Peter Rimmer, Jonathan Cheesbrough, Zhaogong Zhi, Tariq H Iqbal, Stefano Pieretti, Vincenzo Maria D'Amore, Luciana Marinelli, Valeria La Pietra, Raffaella Sorrentino, Luisa Costa, Francesco Caso, Raffaele Scarpa, Giuseppe Cirino, Antonio Randazzo, Mariarosaria Bucci, Helen Michelle McGettrick, Asif Jilani Iqbal, Francesco Maione
Inflammatory bowel diseases (IBDs) are chronic intestinal disorders often characterized by a dysregulation of T cells, specifically T helper (Th) 1, 17 and T regulatory (Treg) repertoire. Increasing evidence demonstrates that dietary polyphenols from Mangifera indica L. extract (MIE, commonly known as mango) mitigate intestinal inflammation and splenic Th17/Treg ratio. In this study, we aimed to dissect the immunomodulatory and anti-inflammatory properties of MIE using a reverse translational approach, by initially using blood from an adult IBD inception cohort and then investigating the mechanism of action in a preclinical model of T cell-driven colitis...
March 23, 2024: Journal of Autoimmunity
https://read.qxmd.com/read/38520637/binary-nano-inhalant-formulation-of-icariin-enhances-cognitive-function-in-vascular-dementia-via-bdnf-trkb-signaling-and-anti-inflammatory-effects
#9
JOURNAL ARTICLE
Tieshu Li, Shuling Li, Yin Xiong, Xinxin Li, Chun Ma, Zhiying Guan, Lihua Yang
Vascular dementia (VaD) has a serious impact on the patients' quality of life. Icariin (Ica) possesses neuroprotective potential for treating VaD, yet its oral bioavailability and blood-brain barrier (BBB) permeability remain challenges. This research introduced a PEG-PLGA-loaded chitosan hydrogel-based binary formulation tailored for intranasal delivery, enhancing the intracerebral delivery efficacy of neuroprotective agents. The formulation underwent optimization to facilitate BBB crossing, with examinations conducted on its particle size, morphology, drug-loading capacity, in vitro release, and biodistribution...
March 23, 2024: Neurochemical Research
https://read.qxmd.com/read/38518829/unpaired-deep-learning-for-pharmacokinetic-parameter-estimation-from-dynamic-contrast-enhanced-mri-without-aif-measurements
#10
JOURNAL ARTICLE
Gyutaek Oh, Yeonsil Moon, Won-Jin Moon, Jong Chul Ye
DCE-MRI provides information about vascular permeability and tissue perfusion through the acquisition of pharmacokinetic parameters. However, traditional methods for estimating these pharmacokinetic parameters involve fitting tracer kinetic models, which often suffer from computational complexity and low accuracy due to noisy arterial input function (AIF) measurements. Although some deep learning approaches have been proposed to tackle these challenges, most existing methods rely on supervised learning that requires paired input DCE-MRI and labeled pharmacokinetic parameter maps...
March 20, 2024: NeuroImage
https://read.qxmd.com/read/38517394/cepharanthine-maintains-integrity-of-the-blood-brain-barrier-bbb-in-stroke-via-the-vegf-vegfr2-zo-1-signaling-pathway
#11
JOURNAL ARTICLE
Yunfang Yang, Changjiang Li, Sijin Yang, Zhuo Zhang, Xue Bai, Hongmei Tang, Jiang Huang
Dysfunction of tight junctions such as zonula occludens protein-1 (ZO-1)-associated aggravation of blood-brain barrier (BBB) permeability plays an important role in the progression of stroke. Cepharanthine (CEP) is an extract from the plant Stephania cepharantha . However, the effects of CEP on stroke and BBB dysfunction have not been previously reported. In this study, we report that CEP improved dysfunction in neurological behavior in a middle cerebral artery occlusion (MCAO) mouse model. Importantly, CEP suppressed blood-brain barrier (BBB) hyperpermeability by increasing the expression of ZO-1...
March 21, 2024: Aging
https://read.qxmd.com/read/38514006/ptgs2-a-potential-immune-regulator-and-therapeutic-target-for-chronic-spontaneous-urticaria
#12
JOURNAL ARTICLE
Yihui Chen, Xingxing Jian, Lei Zhu, Pian Yu, Xiaoqing Yi, Qiaozhi Cao, Jiayi Wang, Feng Xiong, Jie Li
AIMS: Chronic spontaneous urticaria (CSU) is a common and debilitating skin disease that is difficult to control with existing treatments, and the pathogenesis of CSU has not been fully revealed. The aim of this study was to explore the underlying mechanisms of CSU and identify potential treatments. MATERIALS AND METHODS: Microarray datasets of CSU were obtained from Gene Expression Omnibus database. Differentially expressed genes between skin lesions of CSU and normal controls (LNS-DEGs) were identified, and the enrichment analyses of LNS-DEGs were performed...
March 19, 2024: Life Sciences
https://read.qxmd.com/read/38506454/current-clinical-evidence-is-insufficient-to-support-hmme-pdt-as-the-first-choice-of-treatment-for-young-children-with-port-wine-birthmarks
#13
REVIEW
Chao Gao, Vi Nguyen, Marcelo L Hochman, Lin Gao, Elliott H Chen, Harold I Friedman, John Stuart Nelson, Wenbin Tan
BACKGROUND: Port wine birthmark (PWB) is a congenital vascular malformation of the skin. Pulsed dye laser (PDL) is the "gold standard" for the treatment of PWB globally. Hematoporphyrin monomethyl ether (HMME or hemoporfin)-mediated photodynamic therapy (HMME-PDT) has emerged as the first choice for PWB treatment, particularly for young children, in many major hospitals in China during the past several decades. AIM: To evaluate whether HMME-PDT is superior to PDL by comparing the clinical efficacies of both modalities...
March 20, 2024: Lasers in Surgery and Medicine
https://read.qxmd.com/read/38505066/promotion-of-non-small-cell-lung-cancer-tumor-growth-by-fhl2-via-inducing-angiogenesis-and-vascular-permeability
#14
JOURNAL ARTICLE
Tengfei Chen, Jun Chen, Qiuyun Chen, Zhipan Liang, Liuying Pan, Jun Zhao, Xiaowei She
BACKGROUND: Antiangiogenetic therapy is one of the effective strategies for non-small cell lung cancer (NSCLC) treatment. Four-and-a-half LIM-domain protein 2 ( FHL2 ) serves as a key function in cell growth and metastasis of multiple cancers, but the role of FHL2 in NSCLC angiogenesis has not been intensely examined. METHODS: FHL2 expression in NSCLC tissues and cell lines and its correlation with patients prognosis were investigated by using The Cancer Genome Atlas (TCGA) database and quantitative polymerase chain reaction (qPCR)...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38502192/intrinsic-endothelial-hyper-responsiveness-to-inflammatory-mediators-drives-acute-episodes-in-models-of-clarkson-disease
#15
JOURNAL ARTICLE
Ararat J Ablooglu, Wei-Sheng Chen, Zhihui Xie, Abhishek Desai, Subrata Paul, Justin B Lack, Linda A Scott, A Robin Eisch, Arkadiusz Z Dudek, Samir M Parikh, Kirk M Druey
Clarkson disease (monoclonal gammopathy-associated idiopathic systemic capillary leak syndrome, ISCLS) is a rare, relapsing-remitting disorder featuring the abrupt extravasation of fluids and proteins into peripheral tissues, which in turn leads to hypotensive shock, severe hemoconcentration, and hypoalbuminemia. Specific leakage factor(s) and pathways in ISCLS are unknown, and there is no effective treatment for acute flares. Here we characterize an autonomous vascular endothelial defect in ISCLS that is recapitulated in patient-derived endothelial cells (ECs) in culture and in a mouse model of disease...
March 19, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38501951/dynamic-contrast-enhanced-mri-quantification-of-altered-vascular-permeability-in-autoimmune-encephalitis
#16
JOURNAL ARTICLE
So-Hyun Ji, Roh-Eul Yoo, Seung Hong Choi, Woo Jin Lee, Soon Tae Lee, Young Hun Jeon, Kyu Sung Choi, Ji Ye Lee, Inpyeong Hwang, Koung Mi Kang, Tae Jin Yun
Background Blood-brain barrier (BBB) permeability change is a possible pathologic mechanism of autoimmune encephalitis. Purpose To evaluate the change in BBB permeability in patients with autoimmune encephalitis as compared with healthy controls by using dynamic contrast-enhanced (DCE) MRI and to explore its predictive value for treatment response in patients. Materials and Methods This single-center retrospective study included consecutive patients with probable or possible autoimmune encephalitis and healthy controls who underwent DCE MRI between April 2020 and May 2021...
March 2024: Radiology
https://read.qxmd.com/read/38498232/granzyme-b-degrades-extracellular-matrix-and-promotes-inflammation-and-choroidal-neovascularization
#17
JOURNAL ARTICLE
Gideon Obasanmi, Manjosh Uppal, Jing Z Cui, Jeanne Xi, Myeong Jin Ju, Jun Song, Eleanor To, Siqi Li, Wania Khan, Darian Cheng, John Zhu, Lyden Irani, Isa Samad, Julie Zhu, Hyung-Suk Yoo, Alexandre Aubert, Jonathan Stoddard, Martha Neuringer, David J Granville, Joanne A Matsubara
Age-related macular degeneration (AMD) is a common retinal neurodegenerative disease among the elderly. Neovascular AMD (nAMD), a leading cause of AMD-related blindness, involves choroidal neovascularization (CNV), which can be suppressed by anti-angiogenic treatments. However, current CNV treatments do not work in all nAMD patients. Here we investigate a novel target for AMD. Granzyme B (GzmB) is a serine protease that promotes aging, chronic inflammation and vascular permeability through the degradation of the extracellular matrix (ECM) and tight junctions...
March 18, 2024: Angiogenesis
https://read.qxmd.com/read/38494646/1-25-oh-2d3-supplementation-alleviates-gut-vascular-barrier-disruption-via-inhibition-of-s100b-adam10-pathway
#18
JOURNAL ARTICLE
Aiwen Feng, Cheng Li, Shaosheng Su, Yingyan Liu
Gut-vascular barrier (GVB) is the second barrier in mucosa to control systemic dissemination of gut bacteria. Severe burns induce enteroglial cells to produce S100B and endothelial cells to generate ADAM10 and cause vitamin D3 insufficiency/deficiency and GVB disruption. It is not clear whether vitamin D3 supplementation attenuates GVB damage via regulation of S100B/ADAM10 pathway. Here, GVB disruption was induced by 30% of total body surface area scalds. Rats were treated with 1,25(OH)2D3 (0.05, 0.5 or 5 μg/kg) or S100B monoclonal antibody (S100BmAb, 10 μg/kg) or GI254023X (ADAM10 inhibitor, 100 mg/kg)...
March 17, 2024: Tissue Barriers
https://read.qxmd.com/read/38492343/the-nlrp3-inhibitor-olt1177-attenuates-brain-injury-in-experimental-intracerebral-hemorrhage
#19
JOURNAL ARTICLE
Mei Fang, Fan Xia, Jiayan Wang, Chengyang Wang, Bang Teng, Shenglan You, Manrui Li, Xiameng Chen, Xin Hu
BACKGROUND AND PURPOSE: It has been reported activation of NLRP3 inflammasome after intracerebral hemorrhage (ICH) ictus exacerbates neuroinflammation and brain injury. We hypothesized that inhibition of NLRP3 by OLT1177 (dapansutrile), a novel NLRP3 inflammasome inhibitor, could reduce brain edema and attenuate brain injury in experimental ICH. METHODS: ICH was induced by injection of autologous blood into basal ganglia in mice models. Sixty-three C57Bl/6 male mice were randomly grouped into the sham, vehicle, OLT1177 (Dapansutrile, 200 mg/kg intraperitoneally) and treated for consecutive three days, starting from 1 h after ICH surgery...
March 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38489029/circulating-small-extracellular-vesicles-mediate-vascular-hyperpermeability-in-diabetes
#20
JOURNAL ARTICLE
Dakota Gustafson, Peter V DiStefano, Xue Fan Wang, Ruilin Wu, Siavash Ghaffari, Crizza Ching, Kumaragurubaran Rathnakumar, Faisal Alibhai, Michal Syonov, Jessica Fitzpatrick, Emilie Boudreau, Cori Lau, Natalie Galant, Mansoor Husain, Ren-Ke Li, Warren L Lee, Rulan S Parekh, Philippe P Monnier, Jason E Fish
AIMS/HYPOTHESIS: A hallmark chronic complication of type 2 diabetes mellitus is vascular hyperpermeability, which encompasses dysfunction of the cerebrovascular endothelium and the subsequent development of associated cognitive impairment. The present study tested the hypothesis that during type 2 diabetes circulating small extracellular vesicles (sEVs) exhibit phenotypic changes that facilitate pathogenic disruption of the vascular barrier. METHODS: sEVs isolated from the plasma of a mouse model of type 2 diabetes and from diabetic human individuals were characterised for their ability to disrupt the endothelial cell (EC) barrier...
March 15, 2024: Diabetologia
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