Elena Boggio, Casimiro Luca Gigliotti, Riccardo Moia, Annamaria Scotta, Ilaria Crespi, Paola Boggione, Lorenzo De Paoli, Clara Deambrogi, Massimiliano Garzaro, Matteo Vidali, Annalisa Chiocchetti, Ian Stoppa, Roberta Rolla, Chiara Dianzani, Chiara Monge, Nausicaa Clemente, Gianluca Gaidano, Umberto Dianzani
The inducible T-cell co-stimulator (ICOS) is a T-cell receptor that, once bound to ICOS ligand (ICOSL) expressed on several cell types including the B-cell lineage, plays a decisive role in adaptive immunity by regulating the interplay between B and T cells. In addition to its immunomodulatory functions, we have shown that ICOS/ICOSL signalling can inhibit the activity of osteoclasts, unveiling a novel mechanism of lymphocyte-bone cells interactions. ICOS and ICOSL can also be found as soluble forms, namely sICOS and sICOSL...
December 26, 2021: British Journal of Haematology