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Leukemia

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https://www.readbyqxmd.com/read/29232687/photochemotherapy-and-graft-versus-leukemia-reaction-in-acute-leukemia-tumor-immunity-and-survival-are-dependent-on-timing-of-photochemotherapy-of-the-skin
#1
Nicolas Feldreich, Olle Ringden, Lennart Emtestam
BACKGROUND: Cure of acute leukemia after transplantation is mediated by the grafted cells. We investigated the graft-versus-leukemia effect (GVL) in patients with cutaneous acute graft-versus-host disease (GVHD) treated with photochemotherapy (psoralen and ultraviolet light type A). METHOD: Forty-seven patients with acute leukemia were followed 5,000 days after transplantation to assess survival and GVL by multivariate analysis. The primary predictor was time to treatment of cutaneous acute GVHD by photochemotherapy separated into treatment start during the first week of acute GVHD versus after the first week of acute GVHD...
December 13, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29232592/the-impact-of-oral-arsenic-and-all-trans-retinoic-acid-on-coagulopathy-in-acute-promyelocytic-leukemia
#2
Hong-Hu Zhu, Zhi-Ping Guo, Jin-Song Jia, Qian Jiang, Hao Jiang, Xiao-Jun Huang
The aim of our study was to evaluate the impact of oral arsenic (the realgar-indigo naturalis formula, RIF) and all-trans retinoic acid (ATRA) on coagulopathy in acute promyelocytic leukemia (APL) compared with intravenous arsenic trioxide (ATO) and ATRA during induction. Mitoxantrone was added to all the patients at a dose of 1.4mg/m2 per day for 5-7 days. D-dimer levels, prothrombin time (PT), fibrinogen (Fbg) levels and the platelet count were comparably analyzed among 83 newly diagnosed APL patients treated with RIF (n=45) or with ATO (n=38)...
November 15, 2017: Leukemia Research
https://www.readbyqxmd.com/read/29232553/synthetic-lethality-of-combined-bcl-2-inhibition-and-p53-activation-in-aml-mechanisms-and-superior-antileukemic-efficacy
#3
Rongqing Pan, Vivian Ruvolo, Hong Mu, Joel D Leverson, Gwen Nichols, John C Reed, Marina Konopleva, Michael Andreeff
Evasion of apoptosis is a hallmark of cancer. Bcl-2 and p53 represent two important nodes in apoptosis signaling pathways. We find that concomitant p53 activation and Bcl-2 inhibition overcome apoptosis resistance and markedly prolong survival in three mouse models of resistant acute myeloid leukemia (AML). Mechanistically, p53 activation negatively regulates the Ras/Raf/MEK/ERK pathway and activates GSK3 to modulate Mcl-1 phosphorylation and promote its degradation, thus overcoming AML resistance to Bcl-2 inhibition...
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232547/aml-therapy-wake-up-the-guardian-and-cut-loose-the-executioners
#4
Dario C Altieri
In this issue of Cancer Cell, Pan et al. show that a combination therapy designed to reactivate the p53 tumor suppressor while antagonizing the anti-apoptotic function of Bcl-2 is highly active in preclinical models of refractory acute myeloid leukemia (AML). The results may move the needle in this hard-to-treat malignancy.
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232178/rapid-decrease-in-krt14-and-tp53-mrna-expression-in-the-buccal-mucosa-of-patients-receiving-total-body-irradiation-for-allogeneic-stem-cell-transplantation
#5
J Chmara, J W L Browning, H Atkins, M Sabloff, B C McKay
The only curative treatment option for relapsed patients with acute myeloid leukemia (AML) is allogeneic stem cell transplantation. Depletion of hematopoietic stem cells and leukemic blast cells is achieved through the systemic administration of DNA damaging agents, including total-body irradiation (TBI) prior to transplantation. Since other tissues are radiosensitive, the identification of biomarkers could facilitate the management of additional toxicities. Buccal keratinocytes are readily accessible and could provide a source of cells for RNA analysis...
December 12, 2017: Radiation Research
https://www.readbyqxmd.com/read/29231971/enzooty-of-non-hodgkin-s-malignant-lymphoma-of-papio-hamadryas-in-sukhumi-monkey-colony-clinical-and-morphological-signs-of-pre-lymphoma
#6
Lelita A Yakovleva, Boris A Lapin, Aslan A Agumava
Inoculation of hamadryas baboons with blood of leukemia ill people-induced malignant non-Hodgkin's lymphoma in experimental animals for a very considerable latency period. At close contact of inoculated baboons with healthy non-inoculated animals, the lymphoma spread between them. The epidemiological analysis, postmortem examination, histological analysis, tissue culturing, and PCR were used for the diagnostics of lymphoma and pre-lymphoma, purification, identification of STLV-1, and HVP viruses. Characteristic clinical and morphological signs designated by us as pre-lymphoma often precede the lymphoma development...
December 12, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/29231963/body-composition-in-long-term-survivors-of-acute-lymphoblastic-leukemia-diagnosed-in-childhood-and-adolescence-a-focus-on-sarcopenic-obesity
#7
Christopher J C Marriott, Lesley F Beaumont, Troy H Farncombe, Amy N Cranston, Uma H Athale, Valerie N Yakemchuk, Colin E Webber, Ronald D Barr
BACKGROUND: The late effects of treatment for acute lymphoblastic leukemia (ALL) include disordered body composition, especially obesity. Less attention has been focused on the loss of skeletal muscle mass (SMM) and the combined morbidity of sarcopenic obesity. METHODS: A cross-sectional study of body composition was undertaken via dual-energy x-ray absorptiometry in 75 long-term survivors of ALL (more than 10 years after the diagnosis). Measures were obtained of the fat mass (FM), fat-free mass (equivalent to the lean body mass [LBM]), and whole-body bone mineral content...
December 12, 2017: Cancer
https://www.readbyqxmd.com/read/29231259/pernio-as-the-presenting-sign-of-blast-crisis-in-acute-lymphoblastic-leukemia
#8
Kelly K Park, Bailey Tayebi, Lily Uihlein, Jodi Speiser, Adnan Mir, Pedram Gerami, Anthony Mancini, Wendy Kim
A previously healthy 5-year-old girl presented with acute onset of blue toes and red spots on the nose and fingers. The striking nature of these lesions, along with the finding of submandibular lymphadenopathy, prompted further evaluation. Laboratory findings were remarkable for anemia, high transaminase levels, and high blast count. Histopathologic findings were consistent with early pernio. Further examination revealed acute B-cell lymphoblastic leukemia. Treatment of the leukemia led to resolution of the pernio...
December 12, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29231051/midostaurin-in-combination-with-standard-chemotherapy-for-treatment-of-newly-diagnosed-fms-like-tyrosine-kinase-3-flt3-mutation-positive-acute-myeloid-leukemia
#9
Miryoung Kim, Sherry Williams
OBJECTIVE: To evaluate the efficacy and safety of midostaurin in combination with standard cytarabine and daunorubicin induction and cytarabine consolidation in newly diagnosed FLT3-mutated acute myeloid leukemia (AML). DATA SOURCE: A literature search of PubMed and MEDLINE (September 2017) was performed using the terms midostaurin, PKC412, FLT3 gene, and acute myeloid leukemia. STUDY SELECTION/DATA EXTRACTION: Clinical trials evaluating the efficacy and safety of midostaurin in combination with standard cytarabine and daunorubicin induction and cytarabine consolidation were reviewed for the treatment of newly diagnosed FLT3-mutated AML...
December 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29230958/treatment-related-mortality-in-relapsed-childhood-acute-lymphoblastic-leukemia
#10
Trausti Oskarsson, Stefan Söderhäll, Johan Arvidson, Erik Forestier, Thomas Leth Frandsen, Marit Hellebostad, Päivi Lähteenmäki, Ólafur G Jónsson, Ida Hed Myrberg, Mats Heyman
BACKGROUND: Treatment of relapsed childhood acute lymphoblastic leukemia (ALL) is particularly challenging due to the high treatment intensity needed to induce and sustain a second remission. To improve results, it is important to understand how treatment-related toxicity impacts survival. PROCEDURE: In this retrospective population-based study, we described the causes of death and estimated the risk for treatment-related mortality in patients with first relapse of childhood ALL in the Nordic Society of Paediatric Haematology and Oncology ALL-92 and ALL-2000 trials...
December 12, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29230832/management-of-chronic-myeloid-leukemia-in-the-setting-of-pregnancy-when-is-leukocytapheresis-appropriate-a-case-report-and-review-of-the-literature
#11
Elizabeth M Staley, Sierra C Simmons, Alexander Z Feldman, Robin G Lorenz, Marisa B Marques, Lance A Williams, X Long Zheng, Huy P Pham
BACKGROUND: Chronic myeloid leukemia (CML) is a common hematologic malignancy; however, its occurrence during pregnancy is unusual due to its low prevalence in females of childbearing age. There are conflicting reports of how to best manage CML in pregnancy, particularly in the setting of leukocytosis. CASE REPORT: A 30-year-old female was diagnosed with CML at 18 weeks' estimated gestational age. On initial presentation she reported fatigue, night sweats, and early satiety, and was found to have a white blood cell (WBC) count of 69...
December 11, 2017: Transfusion
https://www.readbyqxmd.com/read/29230244/tumor-lysis-syndrome-in-patients-with-hematological-malignancies
#12
REVIEW
Yohannes Belay, Ketsela Yirdaw, Bamlaku Enawgaw
Tumor lysis syndrome is a metabolic complication that may follow the initiation of cancer therapy. It commonly occurs in hematological malignant patients particularly non-Hodgkin's lymphoma and acute leukemia due to chemotherapy or spontaneously. It is characterized by a biochemical abnormality such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia and its clinical outcome is directly related to these biochemical abnormalities. Prevention and treatment of tumor lysis syndrome depend on immediate recognition of patients at risk...
2017: Journal of Oncology
https://www.readbyqxmd.com/read/29230125/older-patients-with-acute-myeloid-leukemia-treatment-challenges-and-future-directions
#13
REVIEW
Laura Finn, Andrew Dalovisio, James Foran
Background: Even though acute myeloid leukemia (AML) occurs most commonly in adults ≥60 years, the treatment of AML in older patients remains a significant challenge. Methods: We reviewed the current literature regarding patient assessment tools, treatment options, and current therapies in clinical trial for patients with AML who are ≥60 years. Results: Our approach to the older patient with AML is evolving with better understanding of the unique disease epidemiology in this population and the development of tools to assess individual patient functional status, including grading systems for comorbidities, geriatric assessment tools, and measurements of frailty...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29229977/proteomic-and-genomic-integration-identifies-kinase-and-differentiation-determinants-of-kinase-inhibitor-sensitivity-in-leukemia-cells
#14
P Casado, E H Wilkes, F Miraki-Moud, M M Hadi, A Rio-Machin, V Rajeeve, R Pike, S Iqbal, S Marfa, N Lea, S Best, J Gribben, J Fitzgibbon, P R Cutillas
Leukemia accepted article preview online, 12 December 2017. doi:10.1038/leu.2017.349.
December 12, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29229640/adverse-effects-of-intravenous-vancomycin-based-prophylaxis-during-therapy-for-pediatric-acute-myeloid-leukemia
#15
Yilun Sun, Rachael L Huskey, Li Tang, Hiroto Inaba, Aditya H Gaur, Raul Ribeiro, Jeffrey E Rubnitz, Joshua Wolf
Background Children and adolescents with acute myeloid leukemia (AML) are at risk of life-threatening bacterial infection, especially with viridans group streptococci. Primary antibacterial prophylaxis with vancomycin-based regimens reduces this risk, but might increase risk of renal or liver toxicity, or Clostridium difficile infection (CDI).Methods A retrospective review was conducted of patients treated for newly diagnosed AML at St. Jude Children's Research Hospital from 2002 to 2008. Nephrotoxicity was classified according to pediatric Risk, Injury, Failure, Loss, End Stage Renal Disease (RIFLE) criteria, and hepatotoxicity according to Common Terminology Criteria for Adverse Events criteria...
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29229602/vegfr-2-mediated-reprogramming-of-mitochondrial-metabolism-regulates-the-sensitivity-of-acute-myeloid-leukemia-to-chemotherapy
#16
Sandrina Nóbrega-Pereira, Francisco Caiado, Tânia Carvalho, Inês Matias, Gonçalo Graça, Luís Gafeira Gonçalves, Bruno Silva-Santos, Haakan Norell, Sérgio Dias
Metabolic reprogramming is central to tumorigenesis, but whether chemotherapy induces metabolic features promoting recurrence remains unknown. We established a mouse xenograft model of human acute myeloid leukemia (AML) that enabled chemotherapy-induced regressions of established disease followed by lethal regrowth of more aggressive tumor cells. Human AML cells from terminally ill mice treated with chemotherapy (chemoAML) had higher lipid content, increased lactate production and ATP levels, reduced expression of PPARG coactivator 1α (PGC-1α), and fewer mitochondria than controls from untreated AML animals...
December 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29229546/changes-in-cognition-and-dendritic-complexity-following-intrathecal-methotrexate-and-cytarabine-treatment-in-a-juvenile-murine-model
#17
Tyler C Alexander, Christy M Simecka, Frederico Kiffer, Thomas Groves, Julie Anderson, Hannah Carr, Jing Wang, Gwendolyn Carter, Antiño R Allen
Acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer and accounts for 26.8% of cancer diagnoses among children, worldwide-approximately 3,000 children each year. While advancements in treating ALL have led to a remission rate of more than 90%, many survivors experience adverse neurocognitive and/or neurobehavioral effects as a result of intrathecal chemotherapy. Methotrexate (MTX) is commonly administered with cytosine arabinoside (AraC, cytarabine) during intrathecal chemotherapy for ALL...
December 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29229137/effects-of-mgso4-on-inhibiting-nod-like-receptor-protein-3-inflammasome-involve-decreasing-intracellular-calcium
#18
Ya-Ying Chang, Ming-Chang Kao, Jui-An Lin, Tsung-Ying Chen, Ching-Feng Cheng, Chih-Shung Wong, I-Shiang Tzeng, Chun-Jen Huang
BACKGROUND: Nod-like receptor protein 3 (NLRP3) inflammasome is a multiprotein complex composed of NLRP3, caspase-1, and apoptosis-associated speck-like protein containing a caspase recruitment domain. Activation of NLRP3 inflammasome leads to interleukin-1β (IL-1β) upregulation and pyroptosis, a proinflammatory cell death characterized by increased cell size. Of note, calcium signaling is crucial for NLRP3 inflammasome activation. This study elucidated the effects of magnesium sulfate (MgSO4), a potent calcium antagonist, on modulating NLRP3 inflammasome...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29228756/interim-pet-ct-may-predict-pfs-and-os-in-t-all-lbl-adult-patients
#19
Liang Wang, Jing-Hua Wang, Xi-Wen Bi, Xiao-Qin Chen, Yue Lu, Zhong-Jun Xia
T lymphoblastic leukemia/lymphoma (T-ALL/LBL) is highly aggressive. Although intensive chemotherapies such as ALL-type regimens are commonly used, about half adult patients eventually relapse and die of T-ALL/LBL. Overwhelming evidences have confirmed that interim PET can predict survival outcomes and guide subsequent treatments in Hodgkin lymphoma. However, whether interim PET-CT can predict survival outcomes or not in T-ALL/LBL patients remains unclear. 47 adult patients of T-ALL/LBL were retrospectively reviewed...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228749/the-bcl2l11-deletion-polymorphism-is-not-associated-with-imatinib-resistance-in-chronic-myeloid-leukemia-patients-meta-analysis
#20
Jinyun Xu, Jiaowei Gu, Yan Zhao, Huihua Meng, Li'an Du, Ruibo Zhang, Hao Jiang, Jianming Luo
A common deletion polymorphism of the gene Bcl-2 like protein 11 (BCL2L11, BIM) has been reported to cause tyrosine kinase inhibitors (TKIs) resistance in several malignant tumors. However, the conclusions were not consistent in chronic myeloid leukemia (CML) individuals. In order to obtain a reliable conclusion, we systematically searched PubMed, Embase, Web of Science, Chinese Biomedical Database, and China National Knowledge Infrastructure and performed the meta-analysis. Six published articles contain 760 East Asian patients were identified from these electronic databases...
November 17, 2017: Oncotarget
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