Tim R E Harris, Zain A Bhutta, Isma Qureshi, Nadir Kharma, Tasleem Raza, Ali Ait Hssain, Ankush Suresh Pathare, Ashwin D'Silva, Mohamad Yahya Khatib, Mohamed Gafar Hussein Mohamedali, Ignacio Miguel Gomez Macineira, Victor Ramon Garcia Hernandez, Jorge Rosales Garcia, Stephen H Thomas, Sameer A Pathan
BACKGROUND: Awake prone position (APP) has been reported to improve oxygenation in patients with COVID-19 disease and to reduce the requirement for invasive mechanical ventilation for patients requiring support with high flow nasal cannula. There is conflicting data for patients requiring lower-level oxygen support. RESEARCH QUESTION: Does APP reduce escalation of oxygen support in COVID-19 patients requiring supplementary oxygen?The primary outcome was defined as an escalation of oxygen support from simple supplementary oxygen (NP, HM, NRB) to NIV (CPAP or BiPAP), HFNC or IMV; OR from NIV (CPAP or BiPAP) or HFNC to IMV by day30...
June 2024: Contemporary Clinical Trials Communications