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https://www.readbyqxmd.com/read/28453595/-eyelid-retraction-of-neurologic-origin-report-of-three-cases
#1
Luis Cartier R, Jorge Guzmán S, Renzo Pasquali F
Eyelid retraction, has received limited attention and it has passively been interpreted as the result of an overactive levator palpebrae superioris muscle secondary to midbrain injury. However, eyelid retractions can occur in other neurological diseases, not directly related with the midbrain. We report three patients who developed eyelid retraction. One patient had a bilateral eyelid retraction, related with Creutzfeldt-Jakob disease (CJD). Another patient had a unilateral right eyelid retraction associated with a thalamic-mesencephalic infarct...
February 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28447150/anatomical-status-of-the-human-palatopharyngeal-sphincter-and-its-functional-implications
#2
Kaori Sumida, Yoshinori Ando, Shinichiro Seki, Kikuji Yamashita, Akira Fujimura, Otto Baba, Seiichiro Kitamura
PURPOSE: The transition muscle between the palatopharyngeus (PP) and the superior constrictor of the pharynx (SCP) encircles the pharyngeal isthmus from behind and is designated as the palatopharyngeal sphincter (PPS). The PPS is inferred to play important roles for velopharyngeal closure, but its existence remains controversial and its roles have been regarded as being played by the SCP. The present study aimed to clarify the anatomical status and functional implications of the PPS. MATERIALS AND METHODS: Macroscopic and microscopic examinations were performed on 39 and 4 cadavers, respectively...
April 26, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28445884/synergistic-action-of-presynaptic-muscarinic-acetylcholine-receptors-and-adenosine-receptors-in-developmental-axonal-competition-at-the-neuromuscular-junction
#3
Laura Nadal, Neus Garcia, Erica Hurtado, Anna Simó, Marta Tomàs, Maria Angel Lanuza, Victor Cilleros, Josep Maria Tomàs
The development of the nervous system involves the initial overproduction of synapses, which promotes connectivity. Hebbian competition between axons with different activities leads to the loss of roughly half of the overproduced elements and this refines connectivity. We used quantitative immunohistochemistry to investigate, in the postnatal day 7 (P7) to P9 neuromuscular junctions, the involvement of muscarinic receptors (muscarinic acetylcholine autoreceptors and the M1, M2, and M4 subtypes) and adenosine receptors (A1 and A2A subtypes) in the control of axonal elimination after the mouse levator auris longus muscle had been exposed to selective antagonists in vivo...
April 27, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28431598/apraclonidine-in-the-treatment-of-ptosis
#4
Subhashie Wijemanne, Dhanya Vijayakumar, Joseph Jankovic
Transient ptosis is a known complication of botulinum toxin (BoNT) injection due to inadvertent migration of toxin into the levator palpebrae superioris muscle. Currently there is no treatment available for BoNT induced ptosis. Apraclonidine hydrochloride is a topical ophthalmic solution with selective alpha-2 and weak alpha-1 receptor agonist activity that has the ability to elevate the eye lid. Apraclonidine has been used as a diagnostic test in Horner's syndrome. We evaluated the effects apraclonidine in a cohort of BoNT induced ptosis and a patient with Horner syndrome...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28412846/changes-in-levator-hiatus-dimensions-during-pregnancy-and-after-delivery-in-nulliparas-a-prospective-cohort-study-using-3d-transperineal-ultrasound
#5
A Sanozidis, T Mikos, E Assimakopoulos, A Athanasiadis, T Tantanassis, B C Tarlatzis, V Papameletiou
PURPOSE: The purpose of this study was to investigate the changes that occur in the levator ani muscle (1) during pregnancy and (2) after labor depending on the mode of delivery in a cohort of nulliparas. MATERIALS & METHODS: A prospective cohort longitudinal study, consisting of 84 primiparas who were examined and recruited in an antenatal clinic was conducted. All participants were submitted to a real-time three-dimensional (3D) ultrasonographic evaluation of the levator ani at (1) 12, (2) 22, and (3) 32 weeks of pregnancy (4) and 4-6 months post delivery...
April 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28412085/in-vivo-evidence-of-significant-levator-ani-muscle-stretch-on-mr-images-of-a-live-childbirth
#6
Nikhil Sindhwani, Christian Bamberg, Nele Famaey, Geertje Callewaert, Joachim W Dudenhausen, Ulf Teichgräber, Jan Deprest
OBJECTIVE: Vaginal childbirth is believed to be a significant risk factor for the development of pelvic floor dysfunction later in life. Previous studies have explored the use of medical imaging and simulations of childbirth to determine the stretch in the levator ani muscle. Bamberg et al, 2012, have recorded MR images of a live childbirth of a 24 year old woman giving birth vaginally for the second time, using a 1.0 Tesla open high-field scanner. Our objective was to determine the stretch ratios in the levator muscle using these MR images of live childbirth...
April 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28397366/changes-in-the-global-strain-of-the-puborectalis-muscle-during-pregnancy-and-postpartum
#7
Anique T M Grob, Niklas Hitschrich, Maria K van de Waarsenburg, Mariëlla I J Withagen, Karlijn J Schweitzer, Carl H van der Vaart
INTRODUCTION: One of the functional parameters that can be assessed by ultrasound is muscle strain. Strain represents the amount of deformation from its original shape when forces are applied to the tissue under study. We set out to assess the global strain of the puborectalis muscle during and after pregnancy. OBJECTIVE: To evaluate the effect of pregnancy and child-delivery on global strain of the puborectalis muscle. METHOD: This is a secondary analysis of a prospective observational study on the association between stress urinary incontinence and levator muscle avulsion after delivery...
April 11, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28384736/examining-a-new-method-to-studying-velopharyngeal-structures-in-a-child-with-22q11-2-deletion-syndrome
#8
Lakshmi Kollara, Graham Schenck, Michael Jaskolka, Jamie L Perry
Purpose: To date, no studies have imaged the velopharynx in children with 22q11.2 deletion syndrome (22q11.2 DS) without the use of sedation. Dysmorphology in velopharyngeal structures has been shown to have significant negative implications on speech among these individuals. This single case study was designed to assess the feasibility of a child-friendly magnetic resonance imaging (MRI) scanning protocol in this clinically challenging population and to determine the utility of this MRI protocol for future work in this area...
April 6, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28383178/endoscopic-endonasal-nasopharyngectomy-tensor-veli-palatine-muscle-as-a-landmark-for-the-parapharyngeal-internal-carotid-artery
#9
Chiung-Lin Liu, Ning-I Hsu, Ping-Hung Shen
BACKGROUND: Endoscopic endonasal nasopharyngectomy(EEN) can be a promising option for select patients with recurrent nasopharyngeal carcinoma, but serious complications can occur in terms of parapharyngeal internal carotid artery (PPICA) injury. Several landmarks have been proposed for locating the PPICA. In this study, we investigated the spatial relationship between the tensor veli palatini (TVP) muscle and the PPICA in a cadaveric model. METHODS: Seven fresh cadaver heads were available for anatomic study...
April 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28380105/accidental-lacrimal-gland-removal-during-resection-of-the-levator-palpebrae-superioris-muscle
#10
Patricia Akaishi, Alicia Galindo-Ferreiro, Sahar M Elkhamary, Zakeya Al-Sadah, Alberto Galvez-Ruiz, A Augusto Cruz
Accidental removal of the lacrimal gland is a rare complication of ptosis surgery. We report two children who underwent large unilateral levator palpebrae superioris resections (LPSr). After surgery, both patients developed dry eye. Post-operatively, the parents of both patients noticed no tears in the affected eye when their child cried. Computed tomography proved the absence of the lacrimal gland in the operated eye in both patients. Oculoplastic surgeons should pay close attention to the anatomy of the levator muscle and its proximity to surrounding tissues in order to avoid lesions on important orbital structures, including the lacrimal gland, and to avoid the development of long-term dry eye...
January 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28378186/a-modified-levator-resection-technique-involving-retention-of-the-levator-palpebrae-superioris-muscle-suspension-system-for-treatment-of-congenital-ptosis
#11
Lan Zuo, Xing X Wang, Xin Y Huang, Jia L Zhang, Yuan Y Du
BACKGROUND: The classical levator resection (LR) technique for correcting ptosis involves separating the levator palpebrae superioris muscle (LPS) completely, which will inevitably collapse the muscle. The modified surgical method involving retention of the LPS suspensory system can allow for more contractility of the levator muscle and thus maximize protection of the eyelid structure. METHODS: Ninety patients (132 eyelids) with different degrees of ptosis were enrolled...
April 4, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28366755/postoperative-ptosis-and-diplopia-induced-by-the-intraoperative-application-of-bone-wax
#12
Yoshinori Maki, Ryota Ishibashi, Daisuke Yamada, Takumi Morita, Masaki Chin, Sen Yamagata
BACKGROUND: Bone wax is a hemostatic agent well used by neurosurgeons to prevent bleeding from bone. However, several complications involving bone wax have been reported, such as ptosis, infection, paraplegia, osteohypertrophy, edema, pain, granuloma formation, allergic reaction and thrombosis. CASE DESCRIPTION: A 47-year-old female patient presented to our neurosurgery department complaining of headache and vomiting. Subarachnoid hemorrhage from a ruptured aneurysm was detected on computed tomography (CT), and we performed emergent clipping of the ruptured aneurysm...
March 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28363748/synthesis-and-biological-evaluation-of-novel-selective-androgen-receptor-modulators-sarms-part-ii-optimization-of-4-pyrrolidin-1-yl-benzonitrile-derivatives
#13
Moriteru Asano, Takenori Hitaka, Takashi Imada, Masami Yamada, Megumi Morimoto, Hiromi Shinohara, Takahito Hara, Masuo Yamaoka, Takashi Santou, Masaharu Nakayama, Yumi Imai, Noriyuki Habuka, Jason Yano, Keith Wilson, Hisashi Fujita, Atsushi Hasuoka
We recently reported a class of novel tissue-selective androgen receptor modulators (SARMs), represented by a naphthalene derivative A. However, their pharmacokinetic (PK) profiles were poor due to low metabolic stability. To improve the PK profiles, we modified the hydroxypyrrolidine and benzonitrile substituents of 4-(pyrrolidin-1-yl)benzonitrile derivative B, which had a comparable potency as that of compound A. This optimization led us to further modifications, which improved metabolic stability while maintaining potent androgen agonistic activity...
May 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28338402/testosterone-plus-finasteride-prevents-bone-loss-without-prostate-growth-in-a-rodent-spinal-cord-injury-model
#14
Joshua F Yarrow, Ean G Phillips, Christine F Conover, Taylor E Bassett, Cong Chen, Tyler Teurlings, Andrea Vasconez, Jonathan Alerte, Hannah M Prock, Jessica M Jiron, Micah Flores, J Ignacio Aguirre, Stephen E Borst, Fan Ye
We have reported that testosterone-enanthate (TE) prevents the musculoskeletal decline occurring acutely after spinal cord injury (SCI), but results in a near doubling of prostate mass. Our purpose was to test the hypothesis that administration of TE plus finasteride (FIN, type II 5α-reductase inhibitor) would prevent the chronic musculoskeletal deficits in our rodent severe contusion SCI model, without inducing prostate enlargement. Forty-three 16-week old male Sprague-Dawley rats received: (1) SHAM surgery (T9 laminectomy), (2) severe (250 kdyne) contusion SCI, (3) SCI+TE (7...
March 24, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28325564/the-effect-of-age-at-surgery-and-compensatory-articulation-on-speech-outcome-in-submucous-cleft-palate-patients-treated-with-double-opposing-z-plasty-a-10-year-experience
#15
Rong-Min Baek, Baek-Kyu Kim, Jae Hoon Jeong, Taeseon Ahn, Mikyong Park, Jihyeon Han
BACKGROUND: Submucous cleft palate is a congenital deformity that may present as velopharyngeal insufficiency. The degree of anatomical abnormality varies widely among patients and does not predict severity of symptom. We present our 10-year experience treating submucous cleft palate patients with double opposing z-plasty and explore the effect of age at surgery and compensatory articulation on speech. METHODS: Preoperative assessment included intraoral examination, nasoendoscopy, and perceptual speech evaluation...
May 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28323222/laparoscopic-nerve-preserving-sacropexy
#16
Alfredo Ercoli, Stefano Cosma, Francesca Riboni, Giuseppe Campagna, Paolo Petruzzelli, Daniela Surico, Saverio Danese, Giovanni Scambia, Chiara Benedetto
STUDY OBJECTIVE: to demonstrate our developed nerve preserving technique during laparoscopic sacropexy (LSP) for multicompartment pelvic organ prolapse. DESIGN: exemplificative case of our surgical procedure based on a multicentric experience consisting of more than 800 cases in 10 years without major intraoperative complications. Informed consent was taken from the subject, and the institutional review board approved this research. SETTING: public practice at Maggiore della Carità University Hospital, Novara; at Sant'Anna Hospital, City of Health and Science, University of Torino; at A...
March 17, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28318922/surgical-rehabilitation-for-anophthalmic-sockets-devoid-of-orbital-implant
#17
Doo-Ri Eo, Yoon-Duck Kim, Kyung In Woo
PURPOSE: To determine the necessity of rehabilitative surgical procedures for no implant anophthalmic sockets, and predictive factors of corrective operations after secondary orbital implantation. MATERIAL AND METHODS: Nineteen unilateral anophthalmic patients without orbital implant were included. The distance of eyebrow, upper eyelid margin, and lower eyelid margin from the horizontal medial canthal line (BM, UM, and LM, respectively) was measured using photographs...
February 13, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28299781/architectural-differences-in-the-anterior-and-middle-compartments-of-the-pelvic-floor-of-young-adult-and-postmenopausal-females
#18
Yi Wu, Noshir F Dabhoiwala, Jaco Hagoort, Li-Wen Tan, Shao-Xiang Zhang, Wouter H Lamers
The pelvic floor guards the passage of the pelvic organs to the exterior. The near-epidemic prevalence of incontinence in women continues to generate interest in the functional anatomy of the pelvic floor. However, due to its complex architecture and poor accessibility, the classical 'dissectional' approach has been unable to come up with a satisfactory description, so that many aspects of its anatomy continue to raise debate. For this reason, we opted for a 'sectional' approach, using the Chinese Visible Human project (four females, 21-35 years) and the Visible Human Project (USA; one female, 59 years) datasets to investigate age-related changes in the architecture of the anterior and middle compartments of the pelvic floor...
March 16, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28296517/therapeutic-algorithm-for-congenital-ptosis-repair-with-levator-resection-and-frontalis-suspension-results-and-literature-review
#19
Riccardo Gazzola, Elena Piozzi, Luca Vaienti, Franz Wilhelm Baruffaldi Preis
BACKGROUND: Several treatments have been described for the treatment of congenital ptosis, but there are few studies that analyze the effectiveness of a therapeutic approach rather than a single technique. AIMS: In this study, we aim to evaluate the effectiveness of our therapeutic algorithm, which relies on levator muscle resection and frontalis suspension with silicone rods, polytetrafluoroethylene (PTFE), or autologous fascia lata. METHODS: We retrospectively analyzed all patients affected by congenital ptosis who underwent corrective surgery at a single department between January 1998 and January 2016...
March 15, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28282764/influence-of-difficulty-of-instrumentation-with-vacuum-on-the-rate-of-levator-ani-muscle-avulsion-identified-by-3-4%C3%A2-d-transperineal-ultrasound
#20
José Antonio García Mejido, Paloma De la Fuente Vaquero, Ana Fernández Palacín, Adriana Aquise Pino, María José Bonomi Barby, José Antonio Sainz Bueno
OBJECTIVES: Evaluation of the influence of difficulty of instrumentation with vacuum on the rate of levator ani muscle (LAM) avulsions. MATERIALS AND METHODS: Prospective observational study with 86 nulliparous women with at term gestation who required instrumentation with vacuum to complete fetal extraction. After every delivery, each explorer reported the number of vacuum tractions needed to complete fetal extraction, as well as the subjective complexity of the instrumentation...
March 1, 2017: Journal of Maternal-fetal & Neonatal Medicine
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