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https://www.readbyqxmd.com/read/28719693/effect-of-high-dose-vs-standard-dose-wintertime-vitamin-d-supplementation-on-viral-upper-respiratory-tract-infections-in-young-healthy-children
#1
Mary Aglipay, Catherine S Birken, Patricia C Parkin, Mark B Loeb, Kevin Thorpe, Yang Chen, Andreas Laupacis, Muhammad Mamdani, Colin Macarthur, Jeffrey S Hoch, Tony Mazzulli, Jonathon L Maguire
Importance: Epidemiological studies support a link between low 25-hydroxyvitamin D levels and a higher risk of viral upper respiratory tract infections. However, whether winter supplementation of vitamin D reduces the risk among children is unknown. Objective: To determine whether high-dose vs standard-dose vitamin D supplementation reduces the incidence of wintertime upper respiratory tract infections in young children. Design, Setting, and Participants: A randomized clinical trial was conducted during the winter months between September 13, 2011, and June 30, 2015, among children aged 1 through 5 years enrolled in TARGet Kids!, a multisite primary care practice-based research network in Toronto, Ontario, Canada...
July 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28712432/alexithymia-in-eating-disorders-systematic-review-and-meta-analyses-of-studies-using-the-toronto-alexithymia-scale
#2
REVIEW
Heather Westwood, Jess Kerr-Gaffney, Daniel Stahl, Kate Tchanturia
OBJECTIVE: The aim of this review was to synthesise the literature on the use of the Toronto Alexithymia Scale (TAS) in eating disorder populations and Healthy Controls (HCs) and to compare TAS scores in these groups. METHOD: Electronic databases were searched systematically for studies using the TAS and meta-analyses were performed to statistically compare scores on the TAS between individuals with eating disorders and HCs. RESULTS: Forty-eight studies using the TAS with both a clinical eating disorder group and HCs were identified...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28712348/an-exploratory-study-of-fatigue-and-physical-activity-in-canadian-thyroid-cancer-patients
#3
Ahmad Alhashemi, Jennifer Jones, David P Goldstein, Daniel Santa Mina, Lehana Thabane, Catherine Sabiston, Eugene K Chang, James Brierley, Anna M Sawka
BACKGROUND: Fatigue is common among cancer survivors, but fatigue in thyroid cancer (TC) survivors may be underappreciated. We investigated the severity and prevalence of moderate and severe fatigue in TC survivors. Potential predictive factors, including physical activity, were explored. METHODS: We performed a cross-sectional, written, self-administered TC patient survey and retrospective chart review in an outpatient academic Endocrinology clinic in Toronto, Canada...
July 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28711574/bath-psoralen-ultraviolet-a-and-narrowband-ultraviolet-b-phototherapy-as-initial-therapy-for-early-stage-mycosis-fungoides-a-retrospective-cohort-of-267-cases-at-the-university-of-toronto
#4
Mohammad Almohideb, Sandra Walsh, Scott Walsh, Neil Shear, Raed Alhusayen
BACKGROUND: Phototherapy is used frequently to treat early-stage mycosis fungoides (MF). The effectiveness of bath psoralen-ultraviolet A (bath PUVA) and narrowband ultraviolet B (nbUVB) in MF is well established. However, evidence is limited comparing the effectiveness of the 2 modalities for early-stage MF. The objective of the present study was to compare the responses between the study participants receiving bath PUVA versus nbUVB phototherapy. PATIENTS AND METHODS: The study included a retrospective cohort of stage 1A and 1B MF patients treated with bath PUVA or nbUVB at their initial presentation...
June 19, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28708081/modeling-the-effects-of-urban-design-on-emergency-medical-response-calls-during-extreme-heat-events-in-toronto-canada
#5
Drew A Graham, Jennifer K Vanos, Natasha A Kenny, Robert D Brown
Urban residents are at risk of health-related illness during extreme heat events but the dangers are not equal in all parts of a city. Previous studies have found a relationship between physical characteristics of neighborhoods and the number of emergency medical response (EMR) calls. We used a human energy budget model to test the effects of landscape modifications that are designed to cool the environment on the expected number of EMR calls in two neighborhoods in Toronto, Canada during extreme heat events...
July 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28704728/development-of-a-novel-multiplexed-qpcr-and-pyrosequencing-method-for-the-detection-of-human-pathogenic-yersiniae
#6
M C Thomas, T W Janzen, G Huscyzynsky, A Mathews, K K Amoako
The purpose of this study was to develop a novel and robust molecular assay for the detection of human pathogenic yersiniae (i.e. Yersinia enterocolitica, Y. pseudotuberculosis and Y. pestis) in complex food samples. The assay combines multiplexed real-time PCR (qPCR) and Pyrosequencing for detecting and differentiating human pathogenic yersiniae with high confidence through sequence based confirmation. The assay demonstrated 100% specificity and inclusivity when tested against a panel of 14 Y. enterocolitica, 22 Y...
June 20, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28704595/results-of-implementation-of-a-hospital-based-strategy-to-reduce-cesarean-delivery-among-low-risk-women-in-canada
#7
Esther S Shoemaker, Ivy L Bourgeault, Carol Cameron, Ian D Graham, Eileen K Hutton
OBJECTIVE: To assess the cesarean delivery (CD) rate among low-risk pregnancies before and after implementation of a hospital-based program in Canada. METHODS: A prospective before-and-after study was conducted to assess the effects of the CARE (CAesarean REduction) strategy, which was developed and implemented at Markham Stouffville Hospital, Toronto, ON, Canada, in 2010 to reduce CD among low-risk women. Hospital records were reviewed to identify changes in the proportions of CD performed during 12 months (April 2009-March 2010) before implementation of the CARE strategy versus 12 months after implementation (April 2012-March 2013) at Markham Stouffville Hospital and 36 hospitals of the same level in the same province...
July 13, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28700527/magnetic-resonance-imaging-in-psoriatic-arthritis-a-descriptive-study-of-indications-features-and-effect-on-treatment-change
#8
Hernán Maldonado-Ficco, Barry J Sheane, Arane Thavaneswaran, Vinod Chandran, Dafna D Gladman
OBJECTIVE: The aims of this study were to describe the indications for, and features of, axial/peripheral joint magnetic resonance imaging (MRI) in psoriatic arthritis (PsA) and to examine the influence of MRI findings on clinical practice. METHODS: All axial and peripheral (hand and/or foot) MRI scans on patients attending the Toronto PsA clinic l between 2003 and 2014 were included. Scan details were garnered from the radiologist's official report. A chart review was performed to determine if MRI findings contributed to a change of treatment...
July 11, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28699149/is-the-clavicula-pro-humero-technique-of-value-for-reconstruction-after-resection-of-the-proximal-humerus-in-children
#9
Dominique Barbier, Benoît De Billy, Philippe Gicquel, Sophie Bourelle, Pierre Journeau
BACKGROUND: There are several options for reconstruction of proximal humerus resections after wide resection for malignant tumors in children. The clavicula pro humero technique is a biologic option that has been used in the past, but there are only scant case reports and small series that comment on the results of the procedure. Because the longevity of children mandates a reconstruction with potential longevity not likely to be achieved by other techniques, the clavicula pro humero technique may be a potential option in selected patients...
July 11, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28692399/risk-assessment-during-the-pan-american-and-parapan-american-games-toronto-2015
#10
Adam van Dijk, Emily Dawson, Kieran Michael Moore, Paul Belanger
During the summer of 2015, the Pan American and Parapan American Games took place in the Greater Toronto area of Ontario, Canada, bringing together thousands of athletes and spectators from around the world. The Acute Care Enhanced Surveillance (ACES) system-a syndromic surveillance system that captures comprehensive hospital visit triage information from acute care hospitals across Ontario-monitored distinct syndromes throughout the games. We describe the creation and use of a risk assessment tool to evaluate alerts produced by ACES during this period...
July 2017: Public Health Reports
https://www.readbyqxmd.com/read/28689706/the-innovative-canadian-pharmacogenomic-screening-initiative-in-community-pharmacy-icanpic-study
#11
John Papastergiou, Peter Tolios, Wilson Li, Jane Li
OBJECTIVES: The safety and efficacy of medications can vary significantly between patients as a result of genetic variability. As genomic screening technologies become more widely available, pharmacists are ideally suited to use such tools to optimize medication therapy management. The objective of this study was to evaluate the feasibility of implementing personalized medication services into community pharmacy practice and to assess the number of drug therapy problems identified as a result of pharmacogenomic screening...
July 6, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28688686/hardware-complications-in-oromandibular-defects-comparing-scapular-and-fibular-based-free-flap-reconstructions
#12
Gordon F Z Tsang, Han Zhang, Christopher Yao, Mirko Kolarski, Patrick J Gullane, Jonathan C Irish, Dale H Brown, Douglas B Chepeha, David P Goldstein, Ralph W Gilbert, John R de Almeida
BACKGROUND: Despite improvements in surgical technique and technology, hardware complications occur relatively frequently. This study analyzes hardware complications in patients undergoing oromandibular reconstruction using scapular (SFF) or fibular (FFF) free flaps. METHODS: Retrospective data for 178 patients was obtained (1999-2014) at University Hospital Network (Toronto, Canada). Univariable and multivariable analyses were performed to identify risk factors for hardware complications...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28688558/bilateral-congenital-cholesteatoma-surgical-treatment-and-considerations
#13
Daniele Marchioni, Alessia Rubini, Mauricio Gonzalez-Navarro, Matteo Alicandri-Ciufelli, Adrian James, Livio Presutti
OBJECTIVES: To describe a multicenter study regarding surgical management of bilateral congenital cholesteatoma (BCC) and underline the importance of endoscopes in the management of this condition. In BCC, hearing preservation is more crucial than in unilateral cases. The endoscopic approach allows complete removal of cholesteatoma via a minimally invasive technique offering low residual disease rates while preserving the normal physiology of the middle ear and possibly the ossicular chain...
August 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28688264/the-role-of-ventromedial-prefrontal-cortex-volume-in-the-association-of-expressive-suppression-and-externally-oriented-thinking
#14
Xu Li, Jiamei Lu, Bingbing Li, Haijiang Li, Li Jin, Jiang Qiu
BACKGROUND: Studies have suggested that expressive suppression (ES) is linked to externally oriented thinking (EOT) through the ventromedial prefrontal cortex (vmPFC), and there are gender differences in their association. The present structural magnetic resonance imaging study was to investigate the neural bases of ES and EOT and their association in females versus males in a Chinese college sample. METHODS: A total of 142 participants (83 females) were enrolled, and they completed the ES subscale of the Emotion Regulation Questionnaire, 20-item Toronto Alexithymia Scale, and anatomical scanning...
June 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28686119/management-of-peripheral-nerve-sheath-tumors-17-years-of-experience-at-toronto-western-hospital
#15
Daipayan Guha, Benjamin Davidson, Mustafa Nadi, Naif M Alotaibi, Michael G Fehlings, Fred Gentili, Taufik A Valiante, Charles H Tator, Michael Tymianski, Abhijit Guha, Gelareh Zadeh
OBJECTIVE A surgical series of 201 benign and malignant peripheral nerve sheath tumors (PNSTs) was assessed to characterize the anatomical and clinical presentation of tumors and identify predictors of neurological outcome, recurrence, and extent of resection. METHODS All surgically treated PNSTs from the Division of Neurosurgery at Toronto Western Hospital from 1993 to 2010 were reviewed retrospectively. Data were collected on patient demographics, clinical presentation, surgical technique, extent of resection, postoperative neurological outcomes, and recurrence...
July 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28686006/mindfulness-based-stress-reduction-in-women-with-overweight-or-obesity-a-randomized-clinical-trial
#16
Nazia Raja-Khan, Katrina Agito, Julie Shah, Christy M Stetter, Theresa S Gustafson, Holly Socolow, Allen R Kunselman, Diane K Reibel, Richard S Legro
OBJECTIVE: To evaluate the feasibility and cardiometabolic effects of mindfulness-based stress reduction (MBSR) in women with overweight or obesity. METHODS: Eighty-six women with BMI ≥ 25 kg/m(2) were randomized to 8 weeks of MBSR or health education and followed for 16 weeks. The primary outcome was the Toronto Mindfulness Scale. Secondary outcomes included the Perceived Stress Scale-10, fasting glucose, and blood pressure. RESULTS: Compared to health education, the MBSR group demonstrated significantly improved mindfulness at 8 weeks (mean change from baseline, 4...
July 7, 2017: Obesity
https://www.readbyqxmd.com/read/28685277/ko-pamoja-the-feasibility-of-a-lay-health-educator-led-breast-and-cervical-screening-program-for-black-women-in-ontario-canada-short-report
#17
Aisha Lofters, Ankur Jain, Winnie Siu, Meghan Kyte, Nakia Lee-Foon, Fran Scott, Onye Nnorom
BACKGROUND: Effective strategies are needed to actively encourage Black women in Canada to adhere to breast and cervical cancer screening and follow-up. In this study, we describe "Ko-Pamoja," a pilot peer education program for breast and cervical cancer screening targeted specifically at Black women in Toronto, Canada. METHODS: We used an Afrocentric lens to design the program, whose purpose was to increase awareness of cancer susceptibility and the benefits of screening for breast and cervical cancer for Black women...
July 6, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28684229/reverse-shoulder-endoprosthesis-for-pathologic-lesions-of-the-proximal-humerus-a-minimum-3-year-follow-up
#18
Simon Maclean, Shahbaz S Malik, Scott Evans, Jonathan Gregory, Lee Jeys
BACKGROUND: The Bayley Walker (Stanmore Implants, Elstree, UK) reversed polarity, linked shoulder replacement is designed to provide stable function in the treatment of a painful shoulder with poor soft tissue coverage. We reviewed the results of the prosthesis in destructive pathologic lesions of the proximal humerus at a United Kingdom tumor center. METHODS: We identified 8 patients (2 men, 6 women) in our database. Clinical information and functional outcome scores were collected, including range of movement, Toronto Extremity Salvage Score, the Musculoskeletal Tumor Score...
July 3, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28683843/canadian-normative-data-for-minimal-assessment-of-cognitive-function-in-multiple-sclerosis
#19
Lisa A S Walker, David Marino, Jason A Berard, Anthony Feinstein, Sarah A Morrow, Denis Cousineau
OBJECTIVE: The Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) is a consensus-based collection of neuropsychological tests that evaluate cognitive functioning in individuals with multiple sclerosis (MS). The tests are typically scored using each respective published test manual, leaving the examiner to make interpretations from norms derived from different American populations. Given demographic differences, this may lead to misinterpretation of findings in Canadians...
July 7, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28683228/effect-of-housing-first-on-suicidal-behaviour-a-randomised-controlled-trial-of-homeless-adults-with-mental-disorders
#20
Joshua P Aquin, Leslie E Roos, Jino Distasio, Laurence Y Katz, Jimmy Bourque, James M Bolton, Shay-Lee Bolton, Jacquelyne Y Wong, Dan Chateau, Julian M Somers, Murray W Enns, Stephen W Hwang, James C Frankish, Jitender Sareen
OBJECTIVE: This study attempted to determine if Housing First (HF) decreased suicidal ideation and attempts compared to treatment as usual (TAU) amongst homeless persons with mental disorders, a population with a demonstrably high risk of suicidal behaviour. METHOD: The At Home/Chez Soi project is an unblinded, randomised control trial conducted across 5 Canadian cities (Vancouver, Winnipeg, Toronto, Montreal, Moncton) from 2009 to 2013. Homeless adults with a diagnosed major mental health disorder were recruited through community agencies and randomised to HF ( n = 1265) and TAU ( n = 990)...
July 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
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