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https://www.readbyqxmd.com/read/29230798/botulinum-toxin-type-a-therapy-for-cervical-dystonia
#1
REVIEW
Mafalda Castelão, Raquel E Marques, Gonçalo S Duarte, Filipe B Rodrigues, Joaquim Ferreira, Cristina Sampaio, Austen P Moore, João Costa
BACKGROUND: This is an update of a Cochrane Review first published in 2005. Cervical dystonia is the most common form of focal dystonia and is a highly disabling movement disorder characterised by involuntary, usually painful, head posturing. Currently, botulinum toxin type A (BtA) is considered the first line therapy for this condition. OBJECTIVES: To compare the efficacy, safety, and tolerability of botulinum toxin type A (BtA) versus placebo in people with cervical dystonia...
December 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29228940/communicating-wisely-teaching-residents-to-communicate-effectively-with-patients-and-caregivers-about-unnecessary-tests
#2
Geetha Mukerji, Adina Weinerman, Sarah Schwartz, Adelle Atkinson, Lynfa Stroud, Brian M Wong
BACKGROUND: With rising healthcare costs and a focus on quality, there is a growing need to promote resource stewardship in medical education. Physicians need to be able to communicate effectively with patients/caregivers seeking tests and treatments that are unnecessary. This study aimed to evaluate the impact of an interactive workshop on residents' knowledge of resource stewardship and communication skills when counseling patients/caregivers about requests for unnecessary testing. METHODS: Participants were 83 Internal Medicine and Pediatrics residents at the University of Toronto in 2014-15...
December 11, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29227790/interpersonal-and-intrapersonal-emotional-processes-in-individuals-treated-for-alcohol-use-disorder-and-non-addicted-healthy-individuals
#3
Maciej Kopera, Elisa M Trucco, Andrzej Jakubczyk, Hubert Suszek, Aneta Michalska, Aleksandra Majewska, Natalia Szejko, Agata Łoczewska, Aleksandra Krasowska, Anna Klimkiewicz, Kirk J Brower, Robert A Zucker, Marcin Wojnar
INTRODUCTION: Prior work largely confirms the presence of various emotional processing deficits among individuals with an alcohol use disorder (AUD); however, their specificity and relevance still warrant investigation. The aim of the current study was to compare selected aspects of emotional processing (i.e., mental state recognition, alexithymia, and emotional intelligence) between individuals treated for an AUD and healthy individuals. METHODS: The AUD sample consisted of 92 abstinent men with AUD who were participating in an 8-week inpatient abstinence-based treatment program in Warsaw, Poland...
December 5, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29227216/front-of-package-nutrition-references-are-positively-associated-with-food-processing
#4
Anthea Christoforou, Naomi Dachner, Rena Mendelson, Valerie Tarasuk
OBJECTIVE: Foods characterized by a high degree of processing are pervasive in the global food supply and concerns have been raised about their contribution to the escalating burden of diet-related disease. It has been suggested that the dominance of these products relates in part to their aggressive on-package marketing. The purpose of the present study was to assess the relationship between the extent and nature of front-of-package (FOP) nutrition references on products sold in Canadian supermarkets and the level of food processing...
January 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29223120/de-icing-salt-contamination-reduces-urban-tree-performance-in-structural-soil-cells
#5
Camilo Ordóñez-Barona, Vadim Sabetski, Andrew A Millward, James Steenberg
Salts used for de-icing roads and sidewalks in northern climates can have a significant impact on water quality and vegetation. Sub-surface engineering systems, such as structural soil cells, can regulate water runoff and pollutants, and provide the necessary soil volume and irrigation to grow trees. However, the ability of such systems to manage de-icing salt contamination, and the impact of this contamination on the trees growing in them, have not been evaluated. We report on an field investigation of de-icing salt contamination in structural cells in two street-revitalization projects in Toronto, Canada, and the impact of this contamination on tree performance...
December 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29221815/corneal-confocal-microscopy-as-a-non-invasive-test-to-assess-diabetic-peripheral-neuropathy
#6
Qian Xiong, Bin Lu, Hong-Ying Ye, Si-Ying Liu, Hang-Ping Zheng, Rui-Yun Zhang, Xiao-Na Qiao, Shuo Zhang, Xiao-Xia Liu, Qing-Chun Li, Na Yi, Liang-Cheng Wu, Jie Wen, Tian-Song Zhang, Yi-Ming Li
OBJECTIVE: To evaluate the efficacy of corneal confocal microscopy (CCM)as a non-invasive test to assess diabetic peripheral neuropathy in Chinese patients diagnosed with type 2 diabetes. RESEARCH DESIGN AND METHODS: Diabetic distal symmetric polyneuropathy (DSPN) and its severity degrees were assessed based on the modified Toronto diagnostic criteria in 128 patients with type 2 diabetes (No DSPN [n = 49], mild DSPN [n = 43], moderate-to-severe DSPN [n = 36]) and 24 age-matched controls...
December 5, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29220727/the-health-impacts-of-weekday-traffic-a-health-risk-assessment-of-pm2-5-emissions-during-congested-periods
#7
Weeberb J Requia, Christopher D Higgins, Matthew D Adams, Moataz Mohamed, Petros Koutrakis
Little work has accounted for congestion, using data that reflects driving patterns, traffic volume, and speed, to examine the association between traffic emissions and human health. In this study, we performed a health risk assessment of PM2.5 emissions during congestion periods in the Greater Toronto and Hamilton Area (GTHA), Canada. Specifically, we used a micro-level approach that combines the Stochastic User Equilibrium Traffic Assignment Algorithm with a MOVES emission model to estimate emissions considering congestion conditions...
December 5, 2017: Environment International
https://www.readbyqxmd.com/read/29214181/cardiac-autonomic-neuropathy-why-should-cardiologists-care-about-that
#8
REVIEW
Andrzej Bissinger
Background: Cardiac autonomic neuropathy (CAN) is a frequent but underdiagnosed complication of diabetes mellitus. It has a strong influence on various cardiac disorders including myocardial ischemia and infarction, hypertension, orthostatic hypotonia, heart failure, and arrhythmias. CAN can lead to severe morbidity and mortality and increase the risk of sudden cardiac death. Methods: This review article summarizes the latest evidence regarding the epidemiology, pathogenesis, influence on the cardiovascular system, and diagnostic methods for CAN...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29212693/clinical-functional-and-radiological-outcomes-of-extracorporeal-irradiation-in-limb-salvage-surgery-for-bone-tumours
#9
C W Jones, J Shatrov, J M Jagiello, S Millington, A Hong, R Boyle, P D Stalley
AIMS: We present a retrospective review of patients treated with extracorporeally irradiated allografts for primary and secondary bone tumours with the mid- and long-term survivorship and the functional and radiographic outcomes. PATIENTS AND METHODS: A total of 113 of 116 (97.4%) patients who were treated with extracorporeally irradiated allografts between 1996 and 2014 were followed up. Forms of treatment included reconstructions, prostheses and composite reconstructions, both with and without vascularised grafts...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29212466/exploring-the-use-of-tablet-computer-based-electronic-data-capture-system-to-assess-patient-reported-measures-among-patients-with-chronic-kidney-disease-a-pilot-study
#10
Dorothy Wong, Shen Cao, Heather Ford, Candice Richardson, Dmitri Belenko, Evan Tang, Luca Ugenti, Eleanor Warsmann, Amanda Sissons, Yalinie Kulandaivelu, Nathaniel Edwards, Marta Novak, Madeline Li, Istvan Mucsi
BACKGROUND: Collecting patient reported outcome measures (PROMs) via computer-based electronic data capture system may improve feasibility and facilitate implementation in clinical care. We report our initial experience about the acceptability of touch-screen tablet computer-based, self-administered questionnaires among patients with chronic kidney disease (CKD), including stage 5 CKD treated with renal replacement therapies (RRT) (either dialysis or transplant). METHODS: We enrolled a convenience sample of patients with stage 4 and 5 CKD (including patients on dialysis or after kidney transplant) in a single-centre, cross-sectional pilot study...
December 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29209585/video-microscope-robotic-arm-assisted-neuronavigation-guided-glioma-resection-and-regional-sampling
#11
Muhammad Waqas, Syed Ather Enam, Fauzan A Hashmi, Fatima Mubarak, Fazal Arain
High-grade gliomas possess internal pathological heterogeneity. Selective sampling of different tumor regions can help in the study of this heterogeneity. In this report, we have described the use of a novel navigation and optical system for the selective regional sampling of a high-grade glioma lesion. A 45-year-old gentleman presented to us with complaints of intermittent frontal headaches for past eight months. On examination, he had subtle pyramidal weakness in left upper and lower extremities. Magnetic resonance imaging (MRI) showed a large contrast-enhancing, space-occupying lesion in the right frontal lobe causing perilesional edema and midline shift...
October 2, 2017: Curēus
https://www.readbyqxmd.com/read/29202886/rhythm-and-rate-control-of-atrial-fibrillation-in-the-emergency-department-a-large-community-based-observational-study
#12
Cameron J Gilbert, Paul Angaran, Zana Mariano, Theresa Aves, Paul Dorian
OBJECTIVE: Atrial fibrillation (AF) is the most common arrhythmia presentation to the emergency department (ED) and frequently results in admission to the hospital. Although rarely life-threatening and not usually an emergent condition, AF places a large burden on our health-care system. The objective of this study was to describe the practices of ED physicians in the management of AF in a large urban Canadian city. METHODS: From January 1, 2010 to December 31, 2010, patients with a primary diagnosis of AF were identified across 10 EDs in Toronto, Canada (N=2,609)...
December 5, 2017: CJEM
https://www.readbyqxmd.com/read/29202861/the-mcmaster-toronto-arthritis-patient-preference-questionnaire-mactar-a-methodological-study-of-reliability-and-minimal-detectable-change-after-a-6%C3%A2-week-period-of-acupuncture-treatment-in-patients-with-rheumatoid-arthritis
#13
Nina Brodin, Wilhelmus J A Grooten, Sara Stråt, Elin Löfberg, Helene Alexanderson
OBJECTIVES: The McMaster Toronto Arthritis patient preference questionnaire (MACTAR) is a semi-structured interview consisting of a baseline and a follow-up interview. The MACTAR baseline is reliable and valid, however the reliability of the MACTAR follow-up is scarcely described. The aim of this study was to describe aspects of reliability and ability to detect changes of the Swedish MACTAR follow-up following acupuncture treatment in individuals with rheumatoid arthritis. RESULTS: The study was of Single Subject Experimental Design, with a 2-week non-interventional A-phase and a 6-week intervention B-phase...
December 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29202605/toxic-epidermal-necrolysis-spectrum-management-at-sunnybrook-health-sciences-centre-our-multidisciplinary-approach-after-review-of-the-current-evidence
#14
Alexandra Mereniuk, Alejandra Jaque, Marc G Jeschke, Neil H Shear
Toxic epidermal necrolysis spectrum (TENS) is a rare yet severe adverse drug reaction associated with a high mortality rate. Beyond supportive care, there is still no established therapy for TENS, although recent meta-analyses and UK guideline recommendations have attempted to offer a review of relevant literature on this difficult topic. As most directed treatments lack clear consensual evidence, care centres often resort to establishing their own strategies. As Canada's largest adult burn centre and the provincial reference centre for most burn patients in Ontario, our team at the Ross Tilley Burn Centre, in collaboration with the Department of Dermatology at Sunnybrook Health Sciences Centre, Toronto, Canada, has managed over 60 confirmed cases of TENS over the past 2 decades...
December 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29198806/toronto-bridges-to-successful-lung-transplantation
#15
EDITORIAL
Dirk Van Raemdonck, Arne Neyrinck, Robin Vos, Geert M Verleden
No abstract text is available yet for this article.
November 7, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29194856/toronto-clinical-neuropathy-score-is-valid-for-a-wide-spectrum-of-polyneuropathies
#16
Alon Abraham, Carolina Barnett, Hans D Katzberg, Leif E Lovblom, Bruce A Perkins, Vera Bril
BACKGROUND: The Toronto Clinical Neuropathy Score (TCNS) is a valid and reliable scale for the diagnosis and staging of diabetic sensorimotor polyneuropathy. In this study, we aimed to explore the performance of the TCNS in non-diabetic polyneuropathies. METHODS: We performed a prospective study from November 2016 to May 2017 of patients with non-diabetic polyneuropathy. Patients had clinical, electrophysiological and functional assessments of their polyneuropathy, and the findings were correlated with the TCNS...
November 30, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29194191/brca-mutation-status-is-not-associated-with-increased-hematologic-toxicity-among-patients-undergoing-platinum-based-chemotherapy-for-ovarian-cancer
#17
Joanne Kotsopoulos, Karla Willows, Sandra Trat, Raymond H Kim, Alexandra Volenik, Ping Sun, Steven A Narod, Jeffrey Boyd, Taymaa May
OBJECTIVE: Women with an inherited BRCA1 or BRCA2 mutation may have an impaired ability to repair chemotherapy-induced damage as a result of a state of haploinsufficiency and may experience greater treatment-related toxicity. The objective of this study was to compare the hematologic adverse effect profiles associated with platinum-based chemotherapy in ovarian cancer patients with and without germline BRCA mutations. METHODS: We conducted a retrospective analysis of patients treated for high-grade serous ovarian cancer at Princess Margaret Cancer Center, Toronto, Ontario between January 2000 and December 2015...
November 30, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29188166/tractography-for-optic-radiation-preservation-in-transcortical-approaches-to-intracerebral-lesions
#18
Vijay Agarwal, James G Malcolm, Gustavo Pradilla, Daniel L Barrow
We present a case of intraventricular meningioma resected via a transcortical approach using tractography for optic radiation and arcuate fasciculus preservation. We include a review of the literature. A 54-year-old woman with a history of breast cancer presented with gait imbalance. Workup revealed a mass in the atrium of the left lateral ventricle consistent with a meningioma. Whole brain automated diffusion tensor imaging (DTI) was used to plan a transcortical resection while sparing the optic radiations and arcuate fasciculus...
September 28, 2017: Curēus
https://www.readbyqxmd.com/read/29188165/diffusion-tensor-imaging-for-ruptured-cerebral-arteriovenous-malformation
#19
Muhammad Waqas, Ayesha Siddiqui, Fatima Mubarak, Syed Ather Enam
Non-ruptured arteriovenous malformations (AVMs) rarely cause tract disruption. Few studies have described how ruptured AVMs influence white matter (WM) tract morphology. We reviewed consecutive AVM cases treated at a tertiary care hospital where diffusion tensor imaging (DTI) tractography was obtained preoperatively. DTI was performed using the Synaptive Plan (Synaptive Medical Inc., Toronto, Canada). Quality control was performed by clinical application specialist. Perinidal fractional anisotropy (FA) value of corticospinal tracts (CST) was obtained...
September 28, 2017: Curēus
https://www.readbyqxmd.com/read/29185801/the-pre-exposure-prophylaxis-prep-stigma-paradox-learning-from-canada-s-first-wave-of-prep-users
#20
Daniel Grace, Jody Jollimore, Paul MacPherson, Matthew J P Strang, Darrell H S Tan
With the emergence of daily oral tenofovir disoproxil fumarate and emtricitabine-based pre-exposure prophylaxis (PrEP) use in Canada, questions have emerged concerning the impacts of this HIV prevention tool on gay men's social and sexual lives. We conducted small focus groups and individual qualitative interviews with 16 gay men in Toronto who were part of the 'first wave' of Canadian PrEP users. Participants were on PrEP for at least one year as part of a demonstration project (November 2014-June 2016). These participants accessed PrEP before regulatory approval by Health Canada in February 2016...
November 29, 2017: AIDS Patient Care and STDs
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