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Murray Finkelstein
OBJECTIVE: To examine the relationship between household income and mortality in a primary care cohort while using personal information obtained from clinical records and administrative data linkages to adjust for confounders. DESIGN: Survey and analysis of data from several administrative databases. SETTING: Toronto, Ont. PARTICIPANTS: Patients of an urban academic family practice who were aged between 45 and 74 and who had made at least 3 visits to the clinic between 1996 and 1997...
April 2018: Canadian Family Physician Médecin de Famille Canadien
Joseph O Okeme, Congqiao Yang, Atousa Abdollahi, Suman Dhal, Shelley A Harris, Liisa M Jantunen, Dina Tsirlin, Miriam L Diamond
Passive air samplers (PAS) were evaluated for measuring indoor concentrations of phthalates, novel brominated flame retardants (N-BFRs), polybrominated diphenyl ethers (PBDEs), and organophosphate esters (OPEs). Sampling rates were obtained from a 50-day calibration study for two newly introduced PAS, polydimethylsiloxane (PDMS) or silicone rubber PAS (one with and one without a coating of styrene divinyl benzene co-polymer, XAD) and the commonly used polyurethane foam (PUF) PAS. Average sampling rates normalized to PAS surface area were 1...
April 9, 2018: Environmental Pollution
Emmanuel Wiernik, Cédric Lemogne, Léopold Fezeu, Nathalie Arnault, Serge Hercberg, Emmanuelle Kesse-Guyot, Pilar Galan
OBJECTIVE: Although alexithymia has been suggested to be associated with cardiovascular diseases, studies are scarce and a causal relationship is questionable. This study explored the prospective association between alexithymia and cardiovascular events in middle-aged participants without cardiovascular history at baseline. METHODS: The 26-item Toronto Alexithymia Scale (TAS-26) was completed by 5,586 participants of the French Supplémentation en Vitamines et Minéraux AntioXydants (SU...
April 11, 2018: Psychosomatic Medicine
Melissa H Manley, Melissa M Legge, Corey E Flanders, Abbie E Goldberg, Lori E Ross
The current study constitutes a qualitative investigation of experiences with and perceptions of consensual non-monogamy (CNM) among a sample of 21 bisexual and plurisexual women with different-gender partners. Participants from Massachusetts, USA, and Toronto, Canada were interviewed four times during pregnancy and the postpartum period. Using an inductive qualitative approach, we found participants were selective about CNM disclosure, and generally apprehensive about stigma surrounding CNM involvement. Additionally, results emphasize the importance of communication, and highlight the range of barriers to and benefits of CNM endorsed by these parents...
April 12, 2018: Journal of Sex & Marital Therapy
Michael K K Leung, Andrew Delong, Brendan J Frey
Motivation: Processing of transcripts at the 3'-end involves cleavage at a polyadenylation site followed by the addition of a poly(A)-tail. By selecting which site is cleaved, the process of alternative polyadenylation enables genes to produce transcript isoforms with different 3'-ends. To facilitate the identification and treatment of disease-causing mutations that affect polyadenylation and to understand the sequence determinants underlying this regulatory process, a computational model that can accurately predict polyadenylation patterns from genomic features is desirable...
April 10, 2018: Bioinformatics
Joshua Harold, Eric Fong
In this paper, we envisage how the sociohistorical experiences of groups are related to their residential patterns. We posit that the residential clustering of a group can be strongly related to the group's mnemonic institutions, which are organizational symbols of collective identity that link the present to the past. We present the case of Jewish residential clustering patterns in Toronto to demonstrate our arguments. We employ 2001 Canadian Census tract-level data to show Jewish residential clustering patterns in relation to the presence of a synagogue or Jewish community center, the mnemonic institutions of Jews...
April 11, 2018: Canadian Review of Sociology, Revue Canadienne de Sociologie
J Tanwani, K Tselios, D D Gladman, J Su, M B Urowitz
Background Lupus myocarditis (LM) is reported in 3-9% of patients with systemic lupus erythematosus (SLE) but limited evidence exists regarding optimal treatment and prognosis. This study aims to describe LM in a defined lupus cohort as compared with the existing literature. Patients and methods Patients with LM were identified from the University of Toronto Lupus Clinic database. Diagnosis was based on clinical manifestations and electrocardiographic, imaging, and biochemical criteria. Demographic, clinical, diagnostic and therapeutic variables and outcomes were collected in a standardized data retrieval form...
January 1, 2018: Lupus
J D Stevenson, R Doxey, A Abudu, M Parry, S Evans, F Peart, L Jeys
Aims Preserving growth following limb-salvage surgery of the upper limb in children remains a challenge. Vascularized autografts may provide rapid biological incorporation with the potential for growth and longevity. In this study, we aimed to describe the outcomes following proximal humeral reconstruction with a vascularized fibular epiphyseal transfer in children with a primary sarcoma of bone. We also aimed to quantify the hypertrophy of the graft and the annual growth, and to determine the functional outcomes of the neoglenofibular joint...
April 1, 2018: Bone & Joint Journal
Thomas R J Todd
The ability to remove longer segments of airway and to extend resections into the larynx proper has managed to create novel situations that will require attention to postoperative management. This article deals with prophylactic measures to prevent the requirement of assisted ventilation. It, however, also emphasizes various bronchoscopic and intubation techniques, which if required, will help to avoid trauma to the airway anastomosis. In addition, a variety of ventilator modalities are discussed that were developed by the author over many years at the Toronto General Hospital...
May 2018: Thoracic Surgery Clinics
Parisa Nicole Fallah, Mark Bernstein
OBJECTIVE There is a global lack of access to surgical care, and this issue disproportionately affects those in low- and middle-income countries. Global surgery academic collaborations (GSACs) between surgeons in high-income countries and those in low- and middle-income countries are one possible sustainable way to address the global surgical need. The objective of this study was to examine the barriers to participation in GSACs and to suggest ways to increase involvement. METHODS A convenience sample of 86 surgeons, anesthesiologists, other physicians, residents, fellows, and nurses from the US, Canada, and Norway was used...
April 6, 2018: Journal of Neurosurgery
Ralph Crott
BACKGROUND: Several mapping or cross-walking algorithms for deriving utilities from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for Cancer (EORTC QLQ-C30) scores have been published in recent years. However, the large majority used ordinary least squares (OLS) regression, which proved to be not very accurate because of the specifics of the quality-of-life measures. OBJECTIVE: Our objective was to compare regression methods that have been used to map EuroQol 5 Dimensions 3 Levels (EQ-5D-3L) utility values from the general EORTC QLQ-C30 using OLS as a benchmark while fixing the number of explanatory variables and to explore an alternative three-part model...
August 7, 2017: PharmacoEconomics Open
George Li, Justin Trac, Shahid Husain, Olusegun Famure, Yanhong Li, S Joseph Kim
BACKGROUND: Kidney transplant recipients (KTR) may be at increased risk for Clostridium difficile infections (CDI) but risk factors and outcomes in this population have not been well studied. METHODS: An observational cohort study was conducted to determine the incidence, risk factors, and outcomes of CDI in KTR. A total of 1,816 KTR transplanted between 2000 and 2013 at Toronto General Hospital were included. Sixty-eight patients developed CDI. Controls were selected at a 4:1 ratio using risk-set sampling and risk factors were explored using conditional logistic regression models...
April 3, 2018: Transplantation
Hong Chen, Qiongsi Li, Jay S Kaufman, Jun Wang, Ray Copes, Yushan Su, Tarik Benmarhnia
BACKGROUND: Ambient air pollution is a major health risk globally. To reduce adverse health effects on days when air pollution is high, government agencies worldwide have implemented air quality alert programmes. Despite their widespread use, little is known about whether these programmes produce any observable public-health benefits. We assessed the effectiveness of such programmes using a quasi-experimental approach. METHODS: We assembled a population-based cohort comprising all individuals who resided in the city of Toronto (Ontario, Canada) from 2003 to 2012 (about 2·6 million people)...
January 2018: Lancet. Planetary Health
Tao Jin, Weifeng Liu, Hairong Xu, Yuan Li, Lin Hao, Xiaohui Niu
BACKGROUND: Whether reconstruction is more beneficial after iliosacral bone tumor resection remains controversial. Because of high rates of complications and recurrence, few patients benefit from reconstruction. The aim of this study is to assess functional outcomes and to reveal changes in the ipsilateral hip joint after partial iliosacral resection. METHODS: From 1998 to 2016, 21 patients aged 20-66 years underwent iliosacral resection, 18 without reconstruction (group 1) and 3 with reconstruction (group 2)...
April 4, 2018: BMC Musculoskeletal Disorders
Victoria C Leung, Simon Fung, Rajeev Muni, Asim Ali
PURPOSE: To report a case of phacomorphic glaucoma following retinal detachment repair with silicone oil in a pediatric patient. STUDY DESIGN: Case report. METHODS: A chart review was conducted at St. Michael's Hospital and The Hospital for Sick Children (Toronto, Canada), where the patient received ophthalmic care from July 28, 2015 onwards. RESULTS: A 14 year-old boy with a history of traumatic retinal detachment and proliferative vitreoretinopathy in the left eye, requiring two pars plana vitrectomies, membrane peel, and silicone oil tamponade, presented with one-day history of decreased vision in the left eye, severe headache, nausea, and vomiting...
April 2, 2018: Journal of Glaucoma
John Hoon Rim, Hyunsoo Kim, Hyukmin Lee, Dongeun Yong, Seok Hoon Jeong, Kyungwon Lee
BACKGROUND: We investigated the molecular epidemiological characteristics and antimicrobial susceptibility pattern of penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates to monitor the change in distribution of bla(TEM) in Korea. METHODS: We collected 804 PPNG isolates from diverse hospitals and clinics mainly located in Seoul, Korea, over a period of 11 years (2005-2015). Isolate susceptibility to seven antimicrobials was determined using the agar dilution test...
July 2018: Annals of Laboratory Medicine
Sarah L Silverberg, Lacey Harding, Rachel F Spitzer, Meb Rashid
Refugees have health needs relating to unstable living situations and poor access to care. We examined the nature of health problems requiring gynaecological referrals for refugee women in Toronto. A retrospective cohort design was used to examine gynaecologic referrals of women at a refugee clinic between December, 2011 and June, 2016. The primary outcome measure was the indications for gynaecological referral. 125 out of 1040 women received a gynaecologic referral for 131 unique concerns. The most common referrals were for abnormal uterine bleeding and cervical dysplasia...
April 2, 2018: Journal of Immigrant and Minority Health
Angela Sekely, Graeme J Taylor, R Michael Bagby
The Toronto Structured Interview for Alexithymia (TSIA) was developed to provide a structured interview method for assessing alexithymia. One drawback of this instrument is the amount of time it takes to administer and score. The current study used item response theory (IRT) methods to analyze data from a large heterogeneous multi-language sample (N = 842) to investigate whether a subset of items could be selected to create a short version of the instrument. Samejima's (1969) graded response model was used to fit the item responses...
March 17, 2018: Psychiatry Research
Amanda Cristian Serafim de Barros, Ana Eliza Romano Furlan, Lucia Helena Neves Marques, Gerardo Maria de Araújo Filho
PURPOSE: Psychogenic nonepileptic seizures (PNES) are paroxysmal episodes superficially resembling epileptic seizures but are not associated with any electrical abnormalities. Despite the existence of recent evidence addressing psychological interventions on PNES, there is a scarcity of studies investigating such interventions on patients with dual diagnoses, such as in temporal lobe epilepsy/mesial temporal sclerosis (TLE-MTS) with comorbid PNES; TLE-MTS is a very frequent epilepsy syndrome found in tertiary centers...
March 27, 2018: Seizure: the Journal of the British Epilepsy Association
O Binns-Hall, D Selvarajah, D Sanger, J Walker, A Scott, S Tesfaye
AIMS: To evaluate the feasibility of a one-stop microvascular screening service for the early diagnosis of diabetic distal symmetrical polyneuropathy, painful distal symmetrical polyneuropathy and the at-risk diabetic foot. METHODS: People with diabetes attending retinal screening in hospital and community settings had their feet examined by a podiatrist. Assessment included: Toronto Clinical Neuropathy Score evaluation; a 10-g monofilament test; and two validated, objective and quick measures of neuropathy obtained using the point-of-care devices 'DPN-Check', a hand-held device that measures sural nerve conduction velocity and amplitude, and 'Sudoscan', a device that measures sudomotor function...
April 2, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
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