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Clinical trialls

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https://www.readbyqxmd.com/read/29761836/acceptability-and-caregiver-reported-outcomes-for-young-children-with-autism-spectrum-disorder-whose-parents-attended-a-preventative-population-based-intervention-for-anxiety-a-pilot-study
#1
Natalie L Bischof, Ronald M Rapee, Kristelle Hudry, Jordana K Bayer
This pilot study explored acceptability to parents and outcomes for children of a preventive intervention for anxiety problems in pre-schoolers with autism spectrum disorder (ASD) who were an identified sub-group within a population-based randomised trial of the Cool Little Kids parenting group programme. The population trial included 545 temperamentally inhibited pre-schoolers recruited across eight economically diverse areas of Melbourne, Australia. Within this sample, 26 parents reported that their child had received an ASD diagnosis...
May 15, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29752502/the-staged-management-of-gleno-humeral-joint-osteonecrosis-in-patients-with-haematological-induced-disease-a-cohort-review
#2
Toby J Colegate-Stone, Saurabh Aggarwal, Karthik Karuppaiah, Adel Tavakkolizadeh, Joydeep Sinha, Ines Lh Reichert
PURPOSE: A formalised, universally accepted, radiological staging system of gleno-humeral joint osteonecrosis (ON) is lacking. Consequently, there is absence of a standardised management strategy. The aim is to propose a simple radiological staging system of gleno-humeral joint ON based on principles of the Association Research Circulation Osseous (ARCO) Society and review of clinical practice. METHODS: A radiographic and clinical review of 45 patients with haematological-induced gleno-humeral ON was performed...
May 11, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29724107/mapping-the-interprofessional-education-landscape-for-students-on-rural-clinical-placements-an-integrative-literature-review
#3
Lorraine Walker, Merylin Cross, Tony Barnett
INTRODUCTION: Interprofessional collaboration and effective teamwork are core to optimising rural health outcomes; however, little is known about the opportunities available for interprofessional education (IPE) in rural clinical learning environments. This integrative literature review addresses this deficit by identifying, analysing and synthesising the research available about the nature of and potential for IPE provided to undergraduate students undertaking rural placements, the settings and disciplines involved and the outcomes achieved...
May 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29705831/deprescribing-benzodiazepines-in-older-patients-impact-of-interventions-targeting-physicians-pharmacists-and-patients
#4
REVIEW
Brendan J Ng, David G Le Couteur, Sarah N Hilmer
Benzodiazepines (BZDs; including the related Z-drugs) are frequently targets for deprescribing; long-term use in older people is harmful and often not beneficial. BZDs can result in significant harms, including falls, fractures, cognitive impairment, car crashes and a significant financial and legal burden to society. Deprescribing BZDs is problematic due to a complex interaction of drug, patient, physician and systematic barriers, including concern about a potentially distressing but rarely fatal withdrawal syndrome...
April 28, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29700828/therapeutic-potential-to-reduce-brain-injury-in-growth-restricted-newborns
#5
Julie A Wixey, Kirat K Chand, Lily Pham, Paul B Colditz, S Tracey Bjorkman
Brain injury in intrauterine growth restricted (IUGR) infants is a major contributing factor to morbidity and mortality worldwide. Adverse outcomes range from mild learning difficulties, to attention difficulties, neurobehavioral issues, cerebral palsy, epilepsy, and other cognitive and psychiatric disorders. While the use of medication to ameliorate neurological deficits in IUGR neonates have been identified as warranting urgent research for several years, few trials have been reported. This review summarises clinical trials focusing on brain protection in the IUGR newborn as well as therapeutic interventions trialled in animal models of IUGR...
April 27, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29697099/japanese-encephalitis-the-prospects-for-new-treatments
#6
REVIEW
Lance Turtle, Tom Solomon
Japanese encephalitis is a mosquito-borne disease that occurs in Asia and is caused by Japanese encephalitis virus (JEV), a member of the genus Flavivirus. Although many flaviviruses can cause encephalitis, JEV causes particularly severe neurological manifestations. The virus causes loss of more disability-adjusted life years than any other arthropod-borne virus owing to the frequent neurological sequelae of the condition. Despite substantial advances in our understanding of Japanese encephalitis from in vitro studies and animal models, studies of pathogenesis and treatment in humans are lagging behind...
April 26, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29690899/the-compas-trial-combined-treatment-model-for-acute-malnutrition-study-protocol-for-the-economic-evaluation
#7
Natasha Lelijveld, Jeanette Bailey, Amy Mayberry, Lani Trenouth, Dieynaba S N'Diaye, Hassan Haghparast-Bidgoli, Chloe Puett
BACKGROUND: Acute malnutrition is currently divided into severe (SAM) and moderate (MAM) based on level of wasting. SAM and MAM currently have separate treatment protocols and products, managed by separate international agencies. For SAM, the dose of treatment is allocated by the child's weight. A combined and simplified protocol for SAM and MAM, with a standardised dose of ready-to-use therapeutic food (RUTF), is being trialled for non-inferior recovery rates and may be more cost-effective than the current standard protocols for treating SAM and MAM...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29663658/understanding-consumers-initial-expectations-of-community-based-residential-mental-health-rehabilitation-in-the-context-of-past-experiences-of-care-a-mixed-methods-pragmatic-grounded-theory-analysis
#8
Stephen Parker, Carla Meurk, Ellie Newman, Clayton Fletcher, Isabella Swinson, Frances Dark
This study explores how consumers expect community-based residential mental health rehabilitation to compare with previous experiences of care. Understanding what consumers hope to receive from mental health services, and listening to their perspectives about what has and has not worked in previous care settings, may illuminate pathways to improved service engagement and outcomes. A mixed-methods research design taking a pragmatic approach to grounded theory guided the analysis of 24 semi-structured interviews with consumers on commencement at three Community Care Units (CCUs) in Australia...
April 16, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29625333/stem-cell-based-therapeutic-strategies-for-cartilage-defects-and-osteoarthritis
#9
REVIEW
Cosimo De Bari, Anke J Roelofs
The gold standard cell therapy for repair of articular cartilage defects is autologous chondrocyte implantation, with good outcomes long-term. Mesenchymal stromal/stem cells (MSCs) from bone marrow or connective tissues such as fat are being pursued as alternatives for cartilage repair, and are trialled via intra-articular administration in patients with knee osteoarthritis. Early-phase clinical studies concur on safety and provide some promising insight into efficacy, but the mechanism of action remains unclear...
April 3, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29609477/virtual-study-groups-and-online-observed-structured-clinical-examinations-practices-enabling-trainees-to-enable-themselves
#10
Dennisa Davidson, Lois Evans
OBJECTIVES: To explore online study groups as augmentation tools in preparing for the Royal Australian and New Zealand College of Psychiatrists Observed Structured Clinical Examinations (OSCE) for fellowship. METHODS: An online survey of New Zealand trainees was carried out to assess exam preparedness and openness to virtual study groups and results analysed. Relevant material around virtual study groups for fellowship examinations was reviewed and used to inform a pilot virtual study group...
March 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29606141/-researchers-have-love-for-life-opportunities-and-barriers-to-engage-pregnant-women-in-malaria-research-in-post-ebola-liberia
#11
Guillermo Martínez Pérez, Christine K Tarr-Attia, Bondey Breeze-Barry, Adelaida Sarukhan, Dawoh Peter Lansana, Ana Meyer García-Sípido, Anna Rosés, María Maixenchs, Quique Bassat, Alfredo Mayor
BACKGROUND: Adoption of prevention and therapeutic innovations to ensure that National Malaria Control Programmes meet their incidence reduction targets is highly dependent on the conduct of rigorous clinical trials. In Liberia, malaria control virtually halted during the recent Ebola epidemic, and could enormously benefit from innovations to protect its most vulnerable populations, including pregnant women, against malaria. Health policy-planners could feel more inclined to adopt novel interventions with demonstrated safety and efficacy when trialled among their women population...
April 2, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29561067/adjunctive-nutrients-in-first-episode-psychosis-a-systematic-review-of-efficacy-tolerability-and-neurobiological-mechanisms
#12
REVIEW
Joseph Firth, Simon Rosenbaum, Philip B Ward, Jackie Curtis, Scott B Teasdale, Alison R Yung, Jerome Sarris
AIM: The effects of nutrient-based treatments, including adjunctive vitamin or antioxidant supplementation, have been explored extensively in long-term schizophrenia. However, no systematic evaluation of trials in "first-episode psychosis" (FEP) has been conducted, despite the potential benefits of using these treatments during the early stages of illness. Therefore, we aimed to review all studies examining efficacy, tolerability and the biological mechanisms of action, of nutrient supplementation in FEP...
March 21, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29540132/royal-australian-and-new-zealand-college-of-psychiatrists-clinical-practice-guidelines-for-mood-disorders-bipolar-disorder-summary
#13
Gin S Malhi, Tim Outhred, Grace Morris, Philip M Boyce, Richard Bryant, Paul B Fitzgerald, Malcolm J Hopwood, Bill Lyndon, Roger Mulder, Greg Murray, Richard J Porter, Ajeet B Singh, Kristina Fritz
In December 2015, the Royal Australian and New Zealand College of Psychiatrists published a comprehensive set of mood disorder clinical practice guidelines for psychiatrists, psychologists and mental health professionals. This guideline summary, directed broadly at primary care physicians, is an abridged version that focuses on bipolar disorder. It is intended as an aid to the management of this complex disorder for primary care physicians working in collaboration with psychiatrists to implement successful long term management...
March 19, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29523614/selective-internal-radiation-therapy-sirt-with-yttrium-90-microspheres-for-unresectable-intrahepatic-cholangiocarcinoma
#14
Vindya Abeysinghe, Siva Sundararajan, Luc Delriviere, Jonathan Tibballs
Unresectableintrahepaticcholangiocarcinoma has a very poor prognosis despite various treatment options. The case presented describes the diagnostic challenges of a young pregnant woman with unresectable cholangiocarcinoma. The current treatment options for cholangiocarcinoma have limited evidence and high recurrence rate. Given the young age of this patient, selective internal radiotherapy was trialled with traditional chemotherapy with a clinically significant result. This case highlights the delays when diagnosing cholangiocarcinoma in younger patients and the possibility of selective internal radiation therapy in combination with chemotherapy as a potential first-line treatment for a complete response in unresectable disease...
March 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29511570/protocol-for-the-star-sheffield-treatments-for-adhd-project-an-internal-pilot-study-assessing-the-feasibility-of-the-trials-within-cohorts-twics-design-to-test-the-effectiveness-of-interventions-for-children-with-adhd
#15
Philippa Fibert, Clare Relton, Tessa Peasgood, David Daley
Background: Attention deficit hyperactivity disorder (ADHD) is a common and growing problem and a leading cause of child referrals to Child and Adult Mental Health Services (CAMHS). It is a drain on resources across nationally funded support agencies and associated with negative outcomes such as early criminality, school disruption and antisocial behaviour. Mainstream interventions (pharmacological and behavioural) demonstrate effectiveness whilst implemented, but are costly, often have unwanted side effects and do not appear to be affecting long-term outcomes...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29456870/a-psychosocial-intervention-for-the-management-of-functional-dysphonia-complex-intervention-development-and-pilot-randomised-trial
#16
Vincent Deary, Elaine McColl, Paul Carding, Tracy Miller, Janet Wilson
Background: Medically unexplained loss or alteration of voice-functional dysphonia-is the commonest presentation to speech and language therapists (SLTs). Besides the impact on personal and work life, functional dysphonia is also associated with increased levels of anxiety and depression and poor general health. Voice therapy delivered by SLTs improves voice but not these associated symptoms. The aims of this research were the systematic development of a complex intervention to improve the treatment of functional dysphonia, and the trialling of this intervention for feasibility and acceptability to SLTs and patients in a randomised pilot study...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29447133/computerised-training-improves-cognitive-performance-in-chronic-pain-a-participant-blinded-randomised-active-controlled-trial-with-remote-supervision
#17
Katharine S Baker, Nellie Georgiou-Karistianis, Amit Lampit, Michael Valenzuela, Stephen J Gibson, Melita J Giummarra
Chronic pain is associated with reduced efficiency of cognitive performance, and few studies have investigated methods of remediation. We trialled a computerised cognitive training protocol to determine whether it could attenuate cognitive difficulties in a chronic pain sample. Thirty-nine adults with chronic pain (mean age = 43.3, 61.5% females) were randomised to an 8-week online course (3 sessions/week from home) of game-like cognitive training exercises, or an active control involving watching documentary videos...
April 2018: Pain
https://www.readbyqxmd.com/read/29379886/improving-colorectal-cancer-referrals
#18
Claire Gregory
The colorectal services at The Royal Bournemouth Hospital needed to adapt to meet the extra demand on fast-track patient referrals to the outpatient department, as a consequence of the changes in the National Institute for Health and Care Excellence (NICE) guidance on cancer referrals in June 2015. Learning from other units, a telephone assessment clinic (TAC) triaging patients straight to colonoscopy was trialled. A Plan-Do-Study-Act (PDSA) methodology was used. A baseline study showed that fast-track colorectal patients referred from their general practitioner (GP) were taking on average 30 days until they received their colonoscopy...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/29329202/epcam-immunotherapy-versus-specific-targeted-delivery-of-drugs
#19
REVIEW
Joanna Macdonald, Justin Henri, Kislay Roy, Emma Hays, Michelle Bauer, Rakesh Naduvile Veedu, Normand Pouliot, Sarah Shigdar
The epithelial cell adhesion molecule (EpCAM), or CD326, was one of the first cancer associated biomarkers to be discovered. In the last forty years, this biomarker has been investigated for use in personalized cancer therapy, with the first monoclonal antibody, edrecolomab, being trialled in humans more than thirty years ago. Since then, several other monoclonal antibodies have been raised to EpCAM and tested in clinical trials. However, while monoclonal antibody therapy has been investigated against EpCAM for almost 40 years as primary or adjuvant therapy, it has not shown as much promise as initially heralded...
January 12, 2018: Cancers
https://www.readbyqxmd.com/read/29284453/a-pilot-exploratory-investigation-on-pregnant-women-s-views-regarding-stan-fetal-monitoring-technology
#20
Kate Bryson, Chris Wilkinson, Sabrina Kuah, Geoff Matthews, Deborah Turnbull
BACKGROUND: Women's views are critical for informing the planning and delivery of maternity care services. ST segment analysis (STan) is a promising method to more accurately detect when unborn babies are at risk of brain damage or death during labour that is being trialled for the first time in Australia. This is the first study to examine women's views about STan monitoring in this context. METHODS: Semi-structured interviews were conducted with pregnant women recruited across a range of clinical locations at the study hospital...
December 29, 2017: BMC Pregnancy and Childbirth
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