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Antibacterial activity

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https://www.readbyqxmd.com/read/27933594/vegetable-peel-waste-for-the-production-of-zno-nanoparticles-and-its-toxicological-efficiency-antifungal-hemolytic-and-antibacterial-activities
#1
T V Surendra, Selvaraj Mohana Roopan, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Gargi Sarkar, K Suthindhiran
Zinc oxide (ZnO) nanoparticles (NPs) are important materials when making different products like sun screens, textiles, and paints. In the current study, the photocatalytic effect of prepared ZnO NPs from Moringa oleifera (M. oleifera) was evaluated on degradation of crystal violet (CV) dye, which is largely released from textile industries and is harmful to the environment. Preliminarily, ZnO NP formation was confirmed using a double beam ultraviolet visible (UV-Vis) spectrophotometer; further, the NP size was estimated using XRD analysis and the functional group analysis was determined using Fourier transform infrared (FT-IR) spectroscopy...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27933586/preparation-and-optimization-of-meropenem-loaded-solid-lipid-nanoparticles-in-vitro-evaluation-and-molecular-modeling
#2
Ellen K G Mhango, Rahul S Kalhapure, Mahantesh Jadhav, Sandeep J Sonawane, Chunderika Mocktar, Suresh Vepuri, Mahmoud Soliman, Thirumala Govender
Encapsulation of antibiotics into nanocarriers has the potential to overcome resistance and disadvantages associated with conventional dosage forms as well as increase half-life of an antibiotic. Encapsulation of meropenem (MRPN) into solid lipid nanoparticles (SLNs) remains unexplored among the limited work reported on nanoformulation incorporating MRPN. The study aimed to use an experimental design, to optimize MRPN-loaded SLNs, and to undertake in vitro and in silico evaluations. A Box-Behnken design (BBD) was used to optimize manufacturing conditions of glycerol monostearate (GMS) SLNs loaded with MRPN...
December 8, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27933456/penicillin-v-acylases-from-gram-negative-bacteria-degrade-n-acylhomoserine-lactones-and-attenuate-virulence-in-pseudomonas-aeruginosa
#3
Avinash Vellore Sunder, Putri Dwi Utari, Sureshkumar Ramasamy, Ronald van Merkerk, Wim Quax, Archana Pundle
Virulence pathways in gram-negative pathogenic bacteria are regulated by quorum sensing mechanisms, through the production and sensing of N-acylhomoserine lactone (AHL) signal molecules. Enzymatic degradation of AHLs leading to attenuation of virulence (quorum quenching) could pave the way for the development of new antibacterials. Penicillin V acylases (PVAs) belong to the Ntn hydrolase superfamily, together with AHL acylases. PVAs are exploited widely in the pharmaceutical industry, but their role in the natural physiology of their native microbes is not clearly understood...
December 8, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27933244/a-study-on-biological-activity-of-marine-fungi-from-different-habitats-in-coastal-regions
#4
Songlin Zhou, Min Wang, Qi Feng, Yingying Lin, Huange Zhao
In recent years, marine fungi have become an important source of active marine natural products. Former researches are limited in habitats selection of fungi with bioactive compounds. In this paper were to measure antibacterial and antitumor cell activity for secondary metabolites of marine fungi, which were isolated from different habitats in coastal regions. 195 strains of marine fungi were isolated and purified from three different habitats. They biologically active experiment results showed that fungi isolation from the mangrove habitats had stronger antibacterial activity than others, and the stains isolated from the estuarial habitats had the least antibacterial activity...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27932272/two-new-triterpenoids-and-a-new-naphthoquinone-derivative-isolated-from-a-hard-coral-derived-fungus-scopulariopsis-sp
#5
Mohamed S Elnaggar, Sherif S Ebada, Mohamed L Ashour, Weaam Ebrahim, Abdelnasser Singab, Wenhan Lin, Zhen Liu, Peter Proksch
Scopulariopsis sp. isolated from the Red Sea hard coral Stylophora sp. yielded two new triterpenoids (1-2) and a new naphthoquinone derivative (8) when cultured on white beans. In addition, fourteen known compounds including three triterpene analogues (3-5), two sesquiterpenoids (6-7), two polyketides (9-10) and seven nitrogenous compounds (11-17) were isolated. All structures were determined through extensive analysis of the NMR and MS data as well as by comparison with literature data. All isolated compounds were evaluated for their cytotoxic, antibacterial and antitubercular activities...
December 5, 2016: Fitoterapia
https://www.readbyqxmd.com/read/27932257/antioxidant-antibacterial-and-anti-aging-activities-of-intracellular-zinc-polysaccharides-from-grifola-frondosa-sh-05
#6
Chen Zhang, Zheng Gao, Chunlong Hu, Jianjun Zhang, Xinyi Sun, Chengbo Rong, Le Jia
In present work, the strain of Grifola frondosa SH-05 was used as a vector of zinc biotransformation to produce the IZPS. The bioactivities including antioxidant and antibacterial activities in vitro and anti-aging properties in vivo of IZPS were investigated comparing with the IPS. The results which were in consistent with the results of histopathology assay demonstrated that the IZPS had superior antioxidant and anti-aging activities by scavenging the hydroxyl and DPPH radicals, increasing enzyme activities, decreasing the MDA contents and ameliorating the anile condition of mice...
December 5, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27931851/spanish-broom-spartium-junceum-l-fibers-impregnated-with-vancomycin-loaded-chitosan-nanoparticles-as-new-antibacterial-wound-dressing-preparation-characterization-and-antibacterial-activity
#7
T Cerchiara, A Abruzzo, R A Ñahui Palomino, B Vitali, R De Rose, G Chidichimo, L Ceseracciu, A Athanassiou, B Saladini, F Dalena, F Bigucci, B Luppi
In this work, we propose as new wound dressing, the Spanish Broom fibers impregnated with vancomycin (VM) loaded chitosan nanoparticles. Spanish Broom fibers were extracted by patented method DiCoDe and the morphological, physical and mechanical properties were investigated. Chitosan nanoparticles were prepared by ionic gelation using different weight ratios between chitosan (CH) and tripolyphosphate (TPP). Nanoparticles were characterized in terms of size, zeta potential, yield, encapsulation efficiency, stability and drug release...
December 5, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27931683/in-silico-pass-analysis-and-determination-of-antimycobacterial-antifungal-and-antioxidant-efficacies-of-maslinic-acid-in-an-extract-rich-in-pentacyclic-triterpenoids
#8
Prasad G Jamkhande, Shahbaz K Pathan, Shailesh J Wadher
OBJECTIVE/BACKGROUND: Microbial infections such as tuberculosis is a major cause of mortality worldwide. Plant-derived phytochemicals have a long history of providing much-needed novel therapeutics. Triterpenoids are among the prominent phytochemicals that possess numerous biological activities. Among them is maslinic acid (MA), a biologically active olean-type pentacyclic triterpenoid. In search of a novel antimicrobial agent, we aimed to evaluate the antimicrobial potential of MA. METHODS: Antibacterial and antifungal activity was evaluated through the agar well diffusion method...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27931116/a-new-diphenyl-ether-derivative-from-mirabilis-himalaica
#9
Si-Yu Zhou, Guo-Wei Wang, Yan-Lin Zou, Li-Qing Deng, Ming-Xu Liu, Zhi-Hua Liao, Xiao-Zhong Lan, Min Chen
One new compound, himalain A (1), together with 12 known compounds were isolated from Mirabilis himalaica. Their structures were determined by spectroscopic methods, including 2D NMR techniques, and the absolute configuration of the 1,2-diol moiety in 1 was defined through Riguera's method. All isolated compounds were tested for their cytotoxic and antibacterial activities.
December 8, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27930849/searching-for-a-potential-antibacterial-lead-structure-against-bacterial-biofilms-among-new-naphthoquinone-compounds
#10
Caroline S Moreira, Ana Carolina J A Silva, Juliana S Novais, Agnes Marie Sá Figueiredo, Vítor F Ferreira, David R da Rocha, Helena C Castro
AIMS: The aims of this study were design, synthesis and the evaluation of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones against gram-negative and Gram-positive strains, including MRSA and its biofilm, to probe for potential lead structures METHODS AND RESULTS: Thus, 36 new analogs were prepared with good yields using a simple, fast, operational three-procedure reaction and a thiol addition to an ο-quinone methide using microwave irradiation. All compounds were tested against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Proteus mirabilis ATCC 15290, Serratia marcescens ATCC 14756, Klebsiella pneumoniae ATCC 4352, Enterobacter cloacae ATCC 23355, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, S...
December 8, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27928613/evaluation-of-the-antibacterial-activity-of-a-cationic-polymer-in-aqueous-solution-with-a-convenient-electrochemical-method
#11
Yihong Wang, Qing Guo, Huafu Wang, Kun Qian, Liang Tian, Chen Yao, Wei Song, Weixia Shu, Ping Chen, Jinxu Qi
Quaternized chitosan is a cationic biopolymer with good antibacterial activity, biocompatibility, and biodegradability, and it has been widely applied in many fields. We have developed a convenient method to evaluate the antibacterial activity of hydroxypropyltrimethylammonium chloride chitosan (HACC) with a nonionic surfactant poloxamer in aqueous solution by monitoring the change of the oxidation peak current in cyclic voltammetry. Increasing values of the oxidation peak current were positively correlated with the antibacterial activity of HACC-poloxamer solutions...
December 7, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27927090/antioxidant-anticholinesterase-and-antibacterial-activities-of-stachys-guyoniana-and-mentha-aquatica
#12
Maria Ferhat, Ebru Erol, Khadidja Aya Beladjila, Yunus Çetintaş, Mehmet Emin Duru, Mehmet Öztürk, Ahmed Kabouche, Zahia Kabouche
CONTEXT: Stachys guyoniana Noë ex. Batt. and Mentha aquatica L. are two Algerian Lamiaceae used in folk medicine. OBJECTIVE: To investigate their antioxidant, anticholinesterase and antibacterial activities. MATERIAL AND METHODS: n-Butanol (BESG), ethyl acetate (EESG) and chloroform (CESG) extracts of S. guyoniana and methanol (MEMA) and chloroform (CEMA) aerial part extracts of M. aquatica and methanol (MERMA) and acetone (AERMA) roots extracts of M...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27927082/effects-of-%C3%AE-caryophyllene-and-murraya-paniculata-essential-oil-in-the-murine-hepatoma-cells-and-in-the-bacteria-and-fungi-24-h-time-kill-curve-studies
#13
Maria Cipriano Selestino Neta, Catia Vittorazzi, Aline Cristina Guimarães, João Damasceno Lopes Martins, Marcio Fronza, Denise Coutinho Endringer, Rodrigo Scherer
CONTEXT: Orange Jessamine [Murraya paniculata L. (Rutaceae)] has been used worldwide in folk medicine as an anti-inflammatory, antibiotic and analgesic. OBJECTIVE: The objective of this study is to investigate the in vitro antioxidant, cytotoxic, antibacterial and antifungal activity and the time-kill curve studies of orange jessamine essential oil and β-caryophyllene, as well as the chemical composition of the essential oil. MATERIAL AND METHODS: The cytotoxic activity of M...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27925615/positive-selection-in-cathelicidin-host-defense-peptides-adaptation-to-exogenous-pathogens-or-endogenous-receptors
#14
S Zhu, B Gao
The cause of adaptive protein evolution includes internal (for example, co-evolution of ligand-receptor pairs) and external (for example, adaptation to different ecological niches) mechanisms. Host defense peptides (HDPs) are a class of vertebrate-specific cationic antimicrobial peptides evolving under positive selection. Besides their antibiotic activity, HDPs also exert an effect on multiple host immune cells, thus providing an ideal model to study selective agents driving their evolution. On the basis of a combination of computational and experimental approaches, we studied the evolution of LL-37-type HDPs in mammals, the mature peptide of cathelicidin CAP18 (herein termed CAP18-MP) and investigated the driving force behind the evolution...
December 7, 2016: Heredity
https://www.readbyqxmd.com/read/27925510/passive-therapy-with-humanized-anti-staphylococcal-enterotoxin-b-antibodies-attenuates-systemic-inflammatory-response-and-protects-from-lethal-pneumonia-caused-by-staphylococcal-enterotoxin-b-producing-staphylococcus-aureus
#15
Melissa J Karau, Mulualem E Tilahun, Ashton Krogman, Barbara A Osborne, Richard A Goldsby, Chella S David, Jayawant N Mandrekar, Robin Patel, Govindarajan Rajagopalan
Drugs such as linezolid that inhibit bacterial protein synthesis may be beneficial in treating infections caused by toxigenic Staphylococcus aureus. As protein synthesis inhibitors have no effect on preformed toxins, neutralization of pathogenic exotoxins with anti-toxin antibodies may be beneficial in conjunction with antibacterial therapy. Herein, we evaluated the efficacy of human-mouse chimeric high-affinity neutralizing anti-staphylococcal enterotoxin B (SEB) antibodies in the treatment of experimental pneumonia caused by SEB-producing S...
December 7, 2016: Virulence
https://www.readbyqxmd.com/read/27925492/antibacterial-antioxidant-and-anti-proliferative-properties-and-zinc-content-of-five-south-portugal-herbs
#16
Ricardo Nunes, Pawel Pasko, Malgorzata Tyszka-Czochara, Agnieszka Szewczyk, Marek Szlosarczyk, Isabel S Carvalho
CONTEXT: Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. luisieri (Lamiaceae) (LS) are all medicinal. OBJECTIVE: To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zinc. MATERIAL AND METHODS: Aerial part extracts were prepared with water (W), ethanol (E) and an 80% mixture (80EW)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27925174/natural-selection-on-immune-defense-a-field-experiment
#17
Laura Langeloh, Jasminca Behrmann-Godel, Otto Seppälä
Predicting the evolution of phenotypic traits requires an understanding of natural selection on them. Despite its indispensability in the fight against parasites, selection on host immune defense has remained understudied. Theory predicts immune traits to be under stabilizing selection due to associated trade-offs with other fitness-related traits. Empirical studies, however, report mainly positive directional selection. This discrepancy could be caused by low phenotypic variation in the examined individuals and/or variation in host resource level that confounds trade-offs in empirical studies...
December 7, 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27925153/targeting-the-hard-to-reach-challenges-and-novel-strategies-in-the-treatment-of-intracellular-bacterial-infections
#18
REVIEW
Nor Fadhilah Kamaruzzaman, Sharon Kendall, Liam Good
Infectious diseases continue to threaten human and animal health and welfare globally, impacting millions of lives and causing substantial economic loss. The use of antibacterials has been only partially successful in reducing disease impact. Bacterial cells are inherently resilient, and the therapy challenge is increased by the development of antibacterial resistance, the formation of biofilms and the ability of certain clinically important pathogens to invade and localize within host cells. Invasion into host cells provides protection from both antibacterials and the host immune system...
November 7, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27924114/total-synthesis-of-%C3%A2-naphthacemycin-a9-possessing-both-antibacterial-activity-against-methicillin-resistant-staphylococcus-aureus-and-circumventing-effect-of-%C3%AE-lactam-resistance
#19
Tomoyasu Hirose, Yasuhiro Kojima, Hidehito Matsui, Hideaki Hanaki, Masato Iwatsuki, Kazuro Shiomi, Satoshi Ōmura, Toshiaki Sunazuka
The total synthesis of KB-3346-5A9, named naphthacemycin A9, has been accomplished by combining the Dötz reaction and Suzuki-Miyaura cross coupling as well as employing Friedel-Crafts reaction with dienone-phenol rearrangement as key steps. We also describe the preparation of the simplified tetarimycin A and naphthacemycin A analogs as a model study, which coincidentally reveal unique properties of naturally occurring naphthacene-5,6,11(12H)-trione framework. The synthesized compounds were evaluated for antibacterial activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus (VRE) to elucidate their structure-activity relationships (SARs), the results of which agreed with a previously reported preliminary SAR study of tetarimycin A...
December 7, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27924113/synthesis-and-antibacterial-activity-of-novel-lincomycin-derivatives-ii-exploring-7s-7-5-aryl-1-3-4-thiadiazol-2-yl-thio-7-deoxylincomycin-derivatives
#20
Ko Kumura, Yoshinari Wakiyama, Kazutaka Ueda, Eijiro Umemura, Takashi Watanabe, Megumi Kumura, Takuji Yoshida, Keiichi Ajito
The synthesis and antibacterial activity of (7S)-7-(5-aryl-1,3,4-thiadiazol-2-yl-thio)-7-deoxylincomycin derivatives are described. These derivatives were mainly prepared by the Mitsunobu reaction of 2,3,4-tris-O-(trimethylsilyl)lincomycin and the corresponding thiols. Exploring structure-activity relationships of the substituent at the 5 position of a thiadiazole ring revealed that compounds with the ortho substituted phenyl group showed improved antibacterial activities against Streptococcus pneumoniae and Streptococcus pyogenes with erm gene compared with the reported compound (1) that had an unsubstituted benzene ring...
December 7, 2016: Journal of Antibiotics
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