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https://www.readbyqxmd.com/read/28734246/topological-pattern-for-the-search-of-new-active-drugs-against-methicillin-resistant-staphylococcus-aureus
#1
Jose I Bueso-Bordils, Maria T Perez-Gracia, Beatriz Suay-Garcia, Maria J Duart, Rafael V Martin Algarra, Luis Lahuerta Zamora, Gerardo M Anton-Fos, Pedro A Aleman Lopez
Molecular topology was used to develop a mathematical model capable of classifying compounds according to antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA). Topological indices were used as structural descriptors and their relation to antimicrobial activity was determined by using linear discriminant analysis. This topological model establishes new structure activity relationships which show that the presence of cyclopropyl, chlorine and ramification pairs at a distance of two bonds favor this activity, while the presence of tertiary amines decreases it...
July 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28731542/total-syntheses-of-cystobactamids-and-structural-confirmation-of-cystobactamid-919-2
#2
Dirk Trauner, Bichu Cheng, Rolf Müller
The cystobactamids are a family of antibacterial natural products with unprecedented chemical scaffolds that are active against both Gram positive and negative pathogens. Herein, we describe the first total synthesis of cystobactamid 919-2 from three fragments. Our convergent synthesis both confirmed the correct structure and determined the absolute configuration of cystobactamid 919-2.
July 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28731389/protease-hydrolysates-of-filefish-thamnaconus-modestus-byproducts-effectively-inhibit-foodborne-pathogens
#3
Shaimaa Hatab, Mei-Ling Chen, Wenhua Miao, Jiheng Lin, Dandan Wu, Changyu Wang, Pengxiang Yuan, Shanggui Deng
In this study, novel antimicrobial peptides had been derived by enzymatic hydrolysis of filefish (Thamnaconus modestus) byproduct (HFBP). Different proteases, (papain [P], trypsin [T], neutrase [N], pepsin [PE], and the mixture I [PN] and mixture II [PT]) and different hydrolysis time (60, 120, 180, and 240 min), have been used to generate peptides with different lengths and amino acid sequences. The antimicrobial properties of HFBPs were tested, against Gram-positive and Gram-negative strains, using disc diffusion method...
July 21, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28731325/bioinspired-and-biomimetic-agnps-gentamicin-embedded-silk-fibroin-coatings-for-robust-antibacterial-and-osteogenetic-applications
#4
Wenhao Zhou, Zhaojun Jia, Pan Xiong, Jianglong Yan, Yangyang Li, Ming Li, Yan Cheng, Yufeng Zheng
With the progressively increasing demand for orthopedic Ti implants, the balance realization between two primary complications restricting implants applications is imperative needed to be solved that the lack of bone tissue integration and biomedical device-associated infections (BAI), where emergence of multi-resistance bacteria make it worse. Notably, a combination of silver nanoparticles (AgNPs) and a kind of antibiotic can synergistically inhibit bacterial growth, where low concentration of AgNPs has been confirmed to promote the proliferation and osteogenesis of osteoblasts...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28730677/discovery-and-total-synthesis-of-natural-cystobactamid-derivatives-with-superior-activity-against-gram-negative-pathogens
#5
Rolf Müller, Stephan Hüttel, Giambattista Testolin, Jennifer Herrmann, Therese Planke, Franziska Gille, Maria Moreno, Marc Stadler, Mark Brönstrup, Andreas Kirschning
Antibiotic discovery and development is challenging as chemical scaffolds of synthetic origin often lack the required pharmaceutical properties, and the discovery of novel ones from natural sources is tedious. Herein we report the discovery of new cystobactamids with a significantly improved antibacterial profile through detailed screening of myxobacterial producer strains. Some of these new derivatives display antibacterial activities in the sub µgmL-1 range against Gram-negative pathogens, including clinical isolates of Klebsiella oxytoca, Pseudomonas aeruginosa, and fluoroquinolone-resistant Enterobacteriaceae, which were not observed for previously reported cystobactamids...
July 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28730403/functional-characterization-of-potential-probiotic-lactic-acid-bacteria-isolated-from-kalarei-and-development-of-probiotic-fermented-oat-flour
#6
Mahak Gupta, Bijender Kumar Bajaj
Considerable variations among probiotics with respect to their health benefitting attributes fuel the research on bioprospecting of proficient probiotic strains from various ecological niches especially the poorly unexplored ones. In the current study, kalarei, an indigenous cheese-like fermented milk product, and other dairy-based sources like curd and raw milk were used for isolation of lactic acid bacteria (LAB). Among 34 LAB isolates, 7 that could withstand simulated gastrointestinal (GI) conditions were characterized for functional probiotic attributes, viz...
July 20, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28730357/biosynthesis-of-silver-nanoparticles-from-spirulina-microalgae-and-its-antibacterial-activity
#7
Govarthanan Muthusamy, Selvankumar Thangasamy, Mythili Raja, Sudhakar Chinnappan, Selvam Kandasamy
The present work focuses on a low-cost, simple, and green synthesis of silver nanoparticles (AgNPs) by mixing AgNO3 solution with the extract of Spirulina platensis (SP) without any chemical reducing and/or capping agents. The green synthesis of AgNPs was confirmed by the color change from colorless to yellowish brown. The biosynthesis of AgNPs was further confirmed by UV-visible spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), biological transmission electron microscopy (Bio-TEM), and energy dispersive X-ray analysis (EDX)...
July 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28730145/prokaryotic-rna-associated-to-bacterial-viability-induces-polymorphonuclear-neutrophil-activation
#8
Nahuel Rodriguez-Rodrigues, Luis A Castillo, Verónica I Landoni, Daiana Martire-Greco, M Ayelén Milillo, Paula Barrionuevo, Gabriela C Fernández
Polymorphonuclear neutrophils (PMN) are the first cellular line of antibacterial host defense. They sense pathogens through recognition of pathogen-associated molecular patterns (PAMPs) by innate pattern recognition receptors, such as Toll-like receptors (TLR). The aim of this study was to investigate whether PMN sense bacterial viability and explore which viability factor could be involved in this phenomenon. For this purpose, different functions were evaluated in isolated human PMN using live Escherichia coli (Ec) and heat-killed Ec (HK-Ec)...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28729223/synthesis-characterization-and-antimicrobial-study-of-polymeric-transition-metal-complexes-of-mn-ii-co-ii-ni-ii-cu-ii-and-zn-ii
#9
Shamim Ahmad Khan, Shahab A A Nami, Shahnawaz Ahmad Bhat, Abdul Kareem, Nahid Nishat
Salen ligands comprising of o-phenylenediamine (salop) and p-phenylenediamine (salpp) have been synthesized. The salen ligand, salop undergo Schiff base reaction with Formaldehyde and Barbituric acid to generate novel polymeric Schiff base, SBOPA in one instance while the second salen ligand, salpp on Schiff base reaction with formaldehyde and piperazine gives another novel polymeric Schiff base, SBPBA. These polymeric Schiff base ligands, SBOPA and SBPBA generates polymeric metal complexes in high yields on reaction with transition metal acetates, M(CH3COO)2...
July 17, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28729216/self-assembled-aunps-for-ingrain-pigmentation-of-silk-fabrics-with-antibacterial-potency
#10
Hanan B Ahmed, Nancy S El-Hawary, Hossam E Emam
Nanogold was self-assembled for ingrain pigmentation of silk fabric with antibacterial properties. The functional groups of silk macromolecular polymeric chains were exploited for generation and stabilization of nanogold. Hydrogen peroxide was used for activation of silk molecular chains through increasing their reactivity and accessibility to be functionalized as manufacturer of nanogold without using any external agents. Effect of procedure sequencing was studied through addition of peroxide firstly (group A) and with Au salt (group B)...
July 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28728600/comparison-of-the-polyphenolic-profile-and-antibacterial-activity-of-the-leaves-fruits-and-flowers-of-rhododendron-ambiguum-and-rhododendron-cinnabarinum
#11
Abhinandan Shrestha, Ahmed Rezk, Inamullah Hakeem Said, Victoria von Glasenapp, Rachelle Smith, Matthias S Ullrich, Hartwig Schepker, Nikolai Kuhnert
BACKGROUND: Rhododendron species have been traditionally used in countries like China, Nepal, Russia and North America for treating human diseases. These species are known to be a good source of polyphenolic plant secondary plant metabolites. They are known to have beneficial health properties for humans and have been used to treat diseases like asthma, skin diseases. In this contribution we investigate the phenolic profile and antibacterial activity of extracts from several plant organs including for the first time from leaves of different development stages...
July 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28727774/inhibitors-of-mycobacterium-marinum-virulence-identified-in-a-dictyostelium-discoideum-host-model
#12
Hajer Ouertatani-Sakouhi, Sébastien Kicka, Gianpaolo Chiriano, Christopher F Harrison, Hubert Hilbi, Leonardo Scapozza, Thierry Soldati, Pierre Cosson
Tuberculosis remains one of the major threats to public health worldwide. Given the prevalence of multi drug resistance (MDR) in Mycobacterium tuberculosis strains, there is a strong need to develop new anti-mycobacterial drugs with modes of action distinct from classical antibiotics. Inhibitors of mycobacterial virulence might target new molecular processes and may represent a potential new therapeutic alternative. In this study, we used a Dictyostelium discoideum host model to assess virulence of Mycobacterium marinum and to identify compounds inhibiting mycobacterial virulence...
2017: PloS One
https://www.readbyqxmd.com/read/28727431/pd-catalyzed-iodide-promoted-%C3%AE-arylation-of-ketones-for-the-regioselective-synthesis-of-isocoumarins
#13
Alessandra Casnati, Raimondo Maggi, Giovanni Maestri, Nicola Della Ca', Elena Motti
A variety of isocoumarins have been synthesized directly from 2-halobenzoates and ketones through a palladium-catalyzed α-arylation step followed by an intramolecular cyclization process. The addition of iodide anions to the reaction mixture increased yields and selectivities especially when 2-bromobenzoates were employed. This phosphine-free one-pot synthesis features a high functional group tolerance and gives access to richly decorated isocoumarins. This general methodology was successful in the total synthesis of Xyridin A, an important natural product with antibacterial and antifungal activity...
July 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28727146/antimicrobial-effects-of-silver-nanoparticles-synthesized-by-fatsia-japonica-leaf-extracts-for-preservation-of-citrus-fruits
#14
Jing Zhang, Guoguo Si, Jun Zou, Ruiliang Fan, Ailing Guo, Xuetuan Wei
Due to their potent antimicrobial activity, silver nanoparticles (AgNPs) synthesized by biomass might be promising in food preservation, whereas effects of AgNPs on Penicillium italicum-induced rot of Citrus fruits have not been investigated. In this study, a novel AgNPs biosynthesis method was developed based on Fatsia japonica leaf extracts. It was revealed that concentrations of leaf extracts, AgNO3 and NaCl affected AgNPs yields and particle sizes obviously. Under the optimized conditions (8 mg/mL extracts, 2 mM AgNO3 and 1 mM NaCl), AgNPs, synthesized within 80 min, showed potent preservative effect against P...
July 20, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28726498/antibacterial-activity-of-extract-and-fractions-from-branches-of-protium-spruceanum-and-cytotoxicity-on-fibroblasts
#15
Tatiane Roquete Amparo, Ivanildes Vasconcelos Rodrigues, Janaína Brandão Seibert, Rafaella Hilda Zaniti Souza, Amanda Ribeiro de Oliveira, Vivette Appolinário Rodrigues Cabral, Paula Melo de Abreu Vieira, Geraldo Célio Brandão, Adriana Akemi Okuma, Sidney Augusto Vieira Filho, Luiz Fernando Medeiros Teixeira, Gustavo Henrique Bianco de Souza
The crude ethanol extract (CEE) and fractions from branches of Protium spruceanum were subjected to antibacterial and cytotoxicity assays. Compounds of the most active fraction were identified by GC-MS and LC-MS. CEE was active against 19 bacteria and the ethyl acetate fraction (EAF) showed the lowest minimum bactericidal concentration (MBC 0.3-80.0 mg/mL). Through time-kill assay was observed that EAF induced rapid bactericidal effect against Staphylococcus saprophyticus. The cytotoxicity tests against L929 fibroblasts showed great potential of EAF on the treatment of infections caused by five bacteria (MBC < IC50)...
July 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28726387/aryl-substituted-ruthenium-ii-complexes-a-strategy-for-enhanced-photocleavage-and-efficient-dna-binding
#16
Felipe Diógenes Abreu, Tercio de F Paulo, Marcelo H Gehlen, Rômulo A Ando, Luiz G F Lopes, Ana Cláudia S Gondim, Mayron A Vasconcelos, Edson H Teixeira, Eduardo Henrique Silva Sousa, Idalina Maria Moreira de Carvalho
Ruthenium polypyridine complexes have shown promise as agents for photodynamic therapy (PDT) and tools for molecular biology (chromophore-assisted light inactivation). To accomplish these tasks, it is important to have at least target selectivity and great reactive oxygen species (ROS) photogeneration: two properties that are not easily found in the same molecule. To prepare such new agents, we synthesized two new ruthenium complexes that combine an efficient DNA binding moiety (dppz ligand) together with naphthyl-modified (1) and anthracenyl-modified (2) bipyridine as a strong ROS generator bound to a ruthenium complex...
July 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28725637/opportunistic-pathogen-porphyromonas-gingivalis-modulates-danger-signal-atp-mediated-antibacterial-nox2-pathways-in-primary-epithelial-cells
#17
JoAnn S Roberts, Kalina R Atanasova, Jungnam Lee, Gill Diamond, Jeff Deguzman, Chul Hee Choi, Özlem Yilmaz
Porphyromonas gingivalis, a major opportunistic pathogen in the etiology of chronic periodontitis, successfully survives in human gingival epithelial cells (GECs). P. gingivalis abrogates the effects of a host danger molecule, extracellular ATP (eATP)/P2X7 signaling, such as the generation of reactive oxygen species (ROS) via the mitochondria and NADPH oxidases (NOX) from primary GECs. However, antimicrobial functions of ROS production are thoroughly investigated in myeloid-lineage immune cells and have not been well-understood in epithelial cells...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28725238/a-non-targeted-metabolomics-approach-unravels-the-vocs-associated-with-the-tomato-immune-response-against-pseudomonas-syringae
#18
María Pilar López-Gresa, Purificación Lisón, Laura Campos, Ismael Rodrigo, José Luis Rambla, Antonio Granell, Vicente Conejero, José María Bellés
Volatile organic compounds (VOCs) emitted by plants are secondary metabolites that mediate the plant interaction with pathogens and herbivores. These compounds may perform direct defensive functions, i.e., acting as antioxidant, antibacterial, or antifungal agents, or indirectly by signaling the activation of the plant's defensive responses. Using a non-targeted GC-MS metabolomics approach, we identified the profile of the VOCs associated with the differential immune response of the Rio Grande tomato leaves infected with either virulent or avirulent strains of Pseudomonas syringae DC3000 pv...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28725148/isolation-biological-evaluation-and-validated-hptlc-quantification-of-the-marker-constituent-of-the-edible-saudi-plant-sisymbrium-irio-l
#19
Shaza M Al-Massarani, Ali A El Gamal, Perwez Alam, Ebtesam S Al-Sheddi, Mai M Al-Oqail, Nida N Farshori
Phytochemical investigation and chromatographic purification of the n-hexane fraction of the aerial parts of the edible Saudi plant Sisymbrium irio led to the isolation of β-sitosterol (1), stigmasterol (2) and β-sitosterol-β-d-glucoside (3). The cytotoxic effects of the n-hexane, dichloromethane, ethyl acetate and n-butanol fractions were tested against three cancer cell lines viz., MCF-7, HCT-116 and HepG2, using the crystal violet staining (CVS) method, while the antibacterial activity against a number of pathogenic bacterial strains, was also estimated using the broth microdilution assay...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28724927/dual-functionality-nanobioconjugates-targeting-intracellular-bacteria-in-cancer-cells-with-enhanced-antimicrobial-activity
#20
Rohini Singh, Smita Patil, Neetu Singh, Shalini Gupta
Bacterial drug resistance has emerged as a serious global threat mandating the development of novel methodologies that allow facile modulation of antimicrobial action in a controlled fashion. Conjugating antibiotics to nanoparticles helps to meet this goal by increasing the drug's overall avidity, bioavailability and easier internalisation into mammalian cells, targeting bacteria that otherwise escape antibacterial action by host cell-localisation. We used polymyxin B sulfate (PMB) and sushi peptide as model drugs against Gram-negative bacteria and established their enhanced antimicrobial activity on Escherichia coli (E...
July 19, 2017: Scientific Reports
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