keyword
MENU ▼
Read by QxMD icon Read
search

YEATS

keyword
https://www.readbyqxmd.com/read/29145630/yaf9-subunit-of-the-nua4-and-swr1-complexes-targets-histone-h3k27ac-through-its-yeats-domain
#1
Brianna J Klein, Salar Ahmad, Kendra R Vann, Forest H Andrews, Zachary A Mayo, Gaelle Bourriquen, Joseph B Bridgers, Jinyong Zhang, Brian D Strahl, Jacques Côté, Tatiana G Kutateladze
Yaf9 is an integral part of the NuA4 acetyltransferase and the SWR1 chromatin remodeling complexes. Here, we show that Yaf9 associates with acetylated histone H3 with high preference for H3K27ac. The crystal structure of the Yaf9 YEATS domain bound to the H3K27ac peptide reveals that the sequence C-terminal to K27ac stabilizes the complex. The side chain of K27ac inserts between two aromatic residues, mutation of which abrogates the interaction in vitro and leads in vivo to phenotypes similar to YAF9 deletion, including loss of SWR1-dependent incorporation of variant histone H2A...
November 14, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29137132/maternal-vitamin-d-status-and-the-relationship-with-neonatal-anthropometric-and-childhood-neurodevelopmental-outcomes-results-from-the-seychelles-child-development-nutrition-study
#2
Eamon Laird, Sally W Thurston, Edwin van Wijngaarden, Conrad F Shamlaye, Gary J Myers, Philip W Davidson, Gene E Watson, Emeir M McSorley, Maria S Mulhern, Alison J Yeates, Mary Ward, Helene McNulty, J J Strain
Vitamin D has an important role in early life; however, the optimal vitamin D status during pregnancy is currently unclear. There have been recent calls for pregnant women to maintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yet little is known about the long-term potential benefits or safety of achieving such high maternal 25(OH)D concentrations for infant or child health outcomes. We examined maternal vitamin D status and its associations with infant anthropometric and later childhood neurocognitive outcomes in a mother-child cohort in a sun-rich country near the equator (4...
November 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29121973/in-vitro-investigations-on-extracellular-proteins-secreted-by-aphanomyces-invadans-the-causative-agent-of-epizootic-ulcerative-syndrome
#3
Muhammad Majeed, Gokhlesh Kumar, Sarah Schlosser, Mansour El-Matbouli, Mona Saleh
BACKGROUND: Proteases produced by many microorganisms, including oomycetes, are crucial for their growth and development. They may also play a critical role in disease manifestation. Epizootic ulcerative syndrome is one of the most destructive fish diseases known. It is caused by the oomycete Aphanomyces invadans and leads to mass mortalities of cultured and wild fish in many countries. The areas of concern are Australia, China, Japan, South and Southeast Asian countries and the USA. Extracellular proteases produced by this oomycete are believed to trigger EUS pathogenesis in fish...
November 9, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29096775/randomized-clinical-trial-of-online-parent-training-for-behavior-problems-after-early-brain-injury
#4
Shari L Wade, Amy E Cassedy, Emily L Shultz, Huaiyu Zang, Nanhua Zhang, Michael W Kirkwood, Terry Stancin, Keith O Yeates, H Gerry Taylor
OBJECTIVE: To evaluate the effectiveness of Internet-based Interacting Together Everyday: Recovery After Childhood TBI (I-InTERACT) versus abbreviated parent training (Express) or access to online resources (internet resources comparison [IRC]) in improving parenting skills and decreasing behavior problems after early traumatic brain injury (TBI). METHOD: In this randomized, controlled, clinical trial, 113 children 3 to 9 years old previously hospitalized for moderate to severe TBI were randomly assigned to receive Express (n = 36), I-InTERACT (n = 39), or IRC (n = 38)...
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29076889/online-problem-solving-for-adolescent-brain-injury-a-randomized-trial-of-2-approaches
#5
Shari L Wade, Hudson Gerry Taylor, Keith Owen Yeates, Michael Kirkwood, Huaiyu Zang, Kelly McNally, Terry Stacin, Nanhua Zhang
OBJECTIVE: Adolescent traumatic brain injury (TBI) contributes to deficits in executive functioning and behavior, but few evidence-based treatments exist. We conducted a randomized clinical trial comparing Teen Online Problem Solving with Family (TOPS-Family) with Teen Online Problem Solving with Teen Only (TOPS-TO) or the access to Internet Resources Comparison (IRC) group. METHODS: Children, aged 11 to 18 years, who sustained a complicated mild-to-severe TBI in the previous 18 months were randomly assigned to the TOPS-Family (49), TOPS-TO (51), or IRC group (52)...
October 27, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29065875/a-randomised-trial-of-the-influence-of-racial-stereotype-bias-on-examiners-scores-feedback-and-recollections-in-undergraduate-clinical-exams
#6
Peter Yeates, Katherine Woolf, Emyr Benbow, Ben Davies, Mairhead Boohan, Kevin Eva
BACKGROUND: Asian medical students and doctors receive lower scores on average than their white counterparts in examinations in the UK and internationally (a phenomenon known as "differential attainment"). This could be due to examiner bias or to social, psychological or cultural influences on learning or performance. We investigated whether students' scores or feedback show influence of ethnicity-related bias; whether examiners unconsciously bring to mind (activate) stereotypes when judging Asian students' performance; whether activation depends on the stereotypicality of students' performances; and whether stereotypes influence examiner memories of performances...
October 25, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29057918/yeats2-links-histone-acetylation-to-tumorigenesis-of-non-small-cell-lung-cancer
#7
Wenyi Mi, Haipeng Guan, Jie Lyu, Dan Zhao, Yuanxin Xi, Shiming Jiang, Forest H Andrews, Xiaolu Wang, Mihai Gagea, Hong Wen, Laszlo Tora, Sharon Y R Dent, Tatiana G Kutateladze, Wei Li, Haitao Li, Xiaobing Shi
Recognition of modified histones by "reader" proteins constitutes a key mechanism regulating diverse chromatin-associated processes important for normal and neoplastic development. We recently identified the YEATS domain as a novel acetyllysine-binding module; however, the functional importance of YEATS domain-containing proteins in human cancer remains largely unknown. Here, we show that the YEATS2 gene is highly amplified in human non-small cell lung cancer (NSCLC) and is required for cancer cell growth and survival...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29051541/helicity-dependent-photocurrent-in-electrically-gated-bi1-x-sb-x-2te3-thin-films
#8
Yu Pan, Qing-Ze Wang, Andrew L Yeats, Timothy Pillsbury, Thomas C Flanagan, Anthony Richardella, Haijun Zhang, David D Awschalom, Chao-Xing Liu, Nitin Samarth
Circularly polarized photons are known to generate a directional helicity-dependent photocurrent in three-dimensional topological insulators at room temperature. Surprisingly, the phenomenon is readily observed at photon energies that excite electrons to states far above the spin-momentum locked Dirac cone and the underlying mechanism for the helicity-dependent photocurrent is still not understood. Here we show a comprehensive study of the helicity-dependent photocurrent in (Bi1-x Sb x )2Te3 thin films as a function of the incidence angle of the optical excitation, its wavelength and the gate-tuned chemical potential...
October 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29048277/retrospective-observational-study-of-atypical-winter-respiratory-illness-season-using-real-time-syndromic-surveillance-england-2014-15
#9
Sue Smith, Roger Morbey, Richard G Pebody, Thomas C Hughes, Simon de Lusignan, F Alex Yeates, Helen Thomas, Sarah J O'Brien, Gillian E Smith, Alex J Elliot
During winter 2014-15, England experienced severe strains on acute health services. We investigated whether syndromic surveillance could contribute to understanding of the unusually high level of healthcare needs. We compared trends for several respiratory syndromic indicators from that winter to historical baselines. Cumulative and mean incidence rates were compared by winter and age group. All-age influenza-like illness was at expected levels; however, severe asthma and pneumonia levels were above those expected...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29037751/discrimination-and-risk-for-suicide-in-later-life
#10
EDITORIAL
Yeates Conwell
No abstract text is available yet for this article.
September 20, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28988864/museum-genomics-confirms-that-the-lord-howe-island-stick-insect-survived-extinction
#11
Alexander S Mikheyev, Andreas Zwick, Michael J L Magrath, Miguel L Grau, Lijun Qiu, You Ning Su, David Yeates
The Lord Howe Island stick insect, Dryococelus australis, was once common on the island but was driven to extinction after the arrival of ship rats in the early 20(th) century [1, 2]. It was thought to be extinct for decades, until a tiny population of similar-looking stick insects was discovered 20 km away, on the islet of Ball's Pyramid, in 2001 [2]. Individuals from this population are currently being reared in Australia and elsewhere in the world, with the eventual goal of recolonizing Lord Howe Island [3]...
October 23, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28984377/age-and-sex-related-effects-in-children-with-mild-traumatic-brain-injury-on-diffusion-magnetic-resonance-imaging-properties-a-comparison-of-voxelwise-and-tractography-methods
#12
Naomi J Goodrich-Hunsaker, Tracy J Abildskov, Garrett Black, Erin D Bigler, Daniel M Cohen, Leslie K Mihalov, Barbara A Bangert, H Gerry Taylor, Keith O Yeates
Although there are several techniques to analyze diffusion-weighted imaging, any technique must be sufficiently sensitive to detect clinical abnormalities. This is especially critical in disorders like mild traumatic brain injury (mTBI), where pathology is likely to be subtle. mTBI represents a major public health concern, especially for youth under 15 years of age. However, the developmental period from birth to 18 years is also a time of tremendous brain changes. Therefore, it is important to establish the degree of age- and sex-related differences...
October 6, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28978678/pufa-status-and-methylmercury-exposure-are-not-associated-with-leukocyte-telomere-length-in-mothers-or-their-children-in-the-seychelles-child-development-study
#13
Alison J Yeates, Sally W Thurston, Huiqi Li, Maria S Mulhern, Emeir M McSorley, Gene E Watson, Conrad F Shamlaye, J J Strain, Gary J Myers, Philip W Davidson, Edwin van Wijngaarden, Karin Broberg
Background: Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on the determinants of TL in early life. Evidence suggests that dietary intake of marine n-3 (ω-3) polyunsaturated fatty acids (PUFAs) is protective of telomere attrition, yet the effect of methylmercury exposure, also found in fish, on TL is unknown.Objective: The aim of this study was to investigate the associations between prenatal PUFA status, methylmercury exposure, and TL in mothers and children in the SCDS (Seychelles Child Development Study), for whom fish consumption is high...
November 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28969306/the-acta-port-score-for-predicting-perioperative-risk-of-blood-transfusion-for-adult-cardiac-surgery
#14
A A Klein, T Collier, J Yeates, L F Miles, S N Fletcher, C Evans, T Richards
Background: A simple and accurate scoring system to predict risk of transfusion for patients undergoing cardiac surgery is lacking. Methods: We identified independent risk factors associated with transfusion by performing univariate analysis, followed by logistic regression. We then simplified the score to an integer-based system and tested it using the area under the receiver operator characteristic (AUC) statistic with a Hosmer-Lemeshow goodness-of-fit test. Finally, the scoring system was applied to the external validation dataset and the same statistical methods applied to test the accuracy of the ACTA-PORT score...
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28958040/physical-health-problems-as-a-late-life-suicide-precipitant-examination-of-coroner-medical-examiner-and-law-enforcement-reports
#15
Namkee G Choi, Diana M DiNitto, C Nathan Marti, Yeates Conwell
Background and Objectives: In light of high late-life suicide rates, we compared older suicide decedents with and without physical health problems as a suicide precipitant with respect to their clinical characteristics and suicide means. We also examined health-related concerns noted in summary coroner/medical examiner or law enforcement (CME/LE) reports. Research Design and Methods: The National Violent Death Reporting System, 2005-2014, provided data (N = 16,924 aged 65 or older)...
September 18, 2017: Gerontologist
https://www.readbyqxmd.com/read/28953005/do-children-who-sustain-traumatic-brain-injury-in-early-childhood-need-and-receive-academic-services-7-years-after-injury
#16
Kathleen M Kingery, Megan E Narad, H Gerry Taylor, Keith Owen Yeates, Terry Stancin, Shari L Wade
OBJECTIVE: To examine the prevalence of academic need, academic service utilization, and unmet need as well as factors associated with academic service utilization 6.8 years after traumatic brain injury (TBI) in early childhood. METHODS: Fifty-eight (16 severe, 14 moderate, 28 complicated mild) children with TBI and 72 children with orthopedic injury (OI) completed the long-term follow-up 6.8 years after injury in early childhood (ages 3-7 years). Injury group differences in rates of need for academic services, academic service utilization, and unmet need as well as factors associated with service utilization and unmet need were examined...
November 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28927484/validation-of-telephone-based-behavioral-assessments-in-aging-services-clients
#17
Yeates Conwell, Adam Simning, Nicole Driffill, Yinglin Xia, Xin Tu, Susan P Messing, David Oslin
BACKGROUND: The Behavioral Health Laboratory (BHL), a telephone-based mental health assessment, is a cost-effective approach that can improve mental illness identification and management. The individual BHL instruments, which were originally designed to be administered in-person, have not yet been validated with an in-person BHL assessment. This study therefore aims to characterize the concordance between the BHL data gathered by telephone and in-person interviews. METHODS: A cross-sectional study was conducted with English-speaking aging services network (ASN) clients aged 60 years and older in Monroe County, NY who were randomized to a BHL interview either in-person (n = 55) or by telephone (n = 53)...
September 20, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28926485/depression-and-depressive-symptoms-in-pediatric-traumatic-brain-injury-a-scoping-review
#18
Christianne Laliberté Durish, Rosemary S Pereverseff, Keith O Yeates
OBJECTIVE: This scoping review aimed to summarize the existing knowledge base regarding depression and depressive symptoms in pediatric traumatic brain injury (TBI) and to identify gaps in the literature in an effort to guide future research. METHODS: MEDLINE Ovid and PsycINFO Ovid databases were each searched by the authors using search terms intended to identify any original research study that examined depressive symptoms in children (ie, aged 0-18 years) with TBI...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28913718/identify-a-shared-neural-circuit-linking-multiple-neuropsychiatric-symptoms-with-alzheimer-s-pathology
#19
Xixi Wang, Ping Ren, Mark Mapstone, Yeates Conwell, Anton P Porsteinsson, John J Foxe, Rajeev D S Raizada, Feng Lin
Neuropsychiatric symptoms (NPS) are common in Alzheimer's disease (AD)-associated neurodegeneration. However, NPS lack a consistent relationship with AD pathology. It is unknown whether any common neural circuits can link these clinically disparate while mechanistically similar features with AD pathology. Here, we explored the neural circuits of NPS in AD-associated neurodegeneration using multivariate pattern analysis (MVPA) of resting-state functional MRI data. Data from 98 subjects (70 amnestic mild cognitive impairment and 28 AD subjects) were obtained...
September 15, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28900003/local-optical-control-of-ferromagnetism-and-chemical-potential-in-a-topological-insulator
#20
Andrew L Yeats, Peter J Mintun, Yu Pan, Anthony Richardella, Bob B Buckley, Nitin Samarth, David D Awschalom
Many proposed experiments involving topological insulators (TIs) require spatial control over time-reversal symmetry and chemical potential. We demonstrate reconfigurable micron-scale optical control of both magnetization (which breaks time-reversal symmetry) and chemical potential in ferromagnetic thin films of Cr-(Bi,Sb)2Te3 grown on SrTiO3 By optically modulating the coercivity of the films, we write and erase arbitrary patterns in their remanent magnetization, which we then image with Kerr microscopy. Additionally, by optically manipulating a space charge layer in the underlying SrTiO3 substrates, we control the local chemical potential of the films...
September 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
118969
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"