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https://www.readbyqxmd.com/read/28926485/depression-and-depressive-symptoms-in-pediatric-traumatic-brain-injury-a-scoping-review
#1
Christianne Laliberté Durish, Rosemary S Pereverseff, Keith O Yeates
OBJECTIVE: This scoping review aimed to summarize the existing knowledge base regarding depression and depressive symptoms in pediatric traumatic brain injury (TBI) and to identify gaps in the literature in an effort to guide future research. METHODS: MEDLINE Ovid and PsycINFO Ovid databases were each searched by the authors using search terms intended to identify any original research study that examined depressive symptoms in children (ie, aged 0-18 years) with TBI...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28913718/identify-a-shared-neural-circuit-linking-multiple-neuropsychiatric-symptoms-with-alzheimer-s-pathology
#2
Xixi Wang, Ping Ren, Mark Mapstone, Yeates Conwell, Anton P Porsteinsson, John J Foxe, Rajeev D S Raizada, Feng Lin
Neuropsychiatric symptoms (NPS) are common in Alzheimer's disease (AD)-associated neurodegeneration. However, NPS lack a consistent relationship with AD pathology. It is unknown whether any common neural circuits can link these clinically disparate while mechanistically similar features with AD pathology. Here, we explored the neural circuits of NPS in AD-associated neurodegeneration using multivariate pattern analysis (MVPA) of resting-state functional MRI data. Data from 98 subjects (70 amnestic mild cognitive impairment and 28 AD subjects) were obtained...
September 15, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28900003/local-optical-control-of-ferromagnetism-and-chemical-potential-in-a-topological-insulator
#3
Andrew L Yeats, Peter J Mintun, Yu Pan, Anthony Richardella, Bob B Buckley, Nitin Samarth, David D Awschalom
Many proposed experiments involving topological insulators (TIs) require spatial control over time-reversal symmetry and chemical potential. We demonstrate reconfigurable micron-scale optical control of both magnetization (which breaks time-reversal symmetry) and chemical potential in ferromagnetic thin films of Cr-(Bi,Sb)2Te3 grown on SrTiO3 By optically modulating the coercivity of the films, we write and erase arbitrary patterns in their remanent magnetization, which we then image with Kerr microscopy. Additionally, by optically manipulating a space charge layer in the underlying SrTiO3 substrates, we control the local chemical potential of the films...
September 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28844078/long-term-effects-of-radiation-therapy-on-white-matter-of-the-corpus-callosum-a-diffusion-tensor-imaging-study-in-children
#4
Monwabisi Makola, M Douglas Ris, E Mark Mahone, Keith Owen Yeates, Kim M Cecil
BACKGROUND: Despite improving survival rates, children are at risk for long-term cognitive and behavioral difficulties following the diagnosis and treatment of a brain tumor. Surgery, chemotherapy and radiation therapy have all been shown to impact the developing brain, especially the white matter. OBJECTIVE: The purpose of this study was to determine the long-term effects of radiation therapy on white matter integrity, as measured by diffusion tensor imaging, in pediatric brain tumor patients 2 years after the end of radiation treatment, while controlling for surgical interventions...
August 26, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28838593/scientific-autobiography
#5
EDITORIAL
Yeates Conwell
No abstract text is available yet for this article.
July 29, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28836809/teen-online-problem-solving-for-teens-with-traumatic-brain-injury-rationale-methods-and-preliminary-feasibility-of-a-teen-only-intervention
#6
Shari L Wade, Megan E Narad, Kathleen M Kingery, H Gerry Taylor, Terry Stancin, Michael W Kirkwood, Keith O Yeates
PURPOSE/OBJECTIVE: To describe the Teen Online Problem Solving-Teen Only (TOPS-TO) intervention relative to the original Teen Online Problem Solving-Family (TOPS-F) intervention, to describe a randomized controlled trial to assess intervention efficacy, and to report feasibility and acceptability of the TOPS-TO intervention. Research method and design: This is a multisite randomized controlled trial, including 152 teens (49 TOPS-F, 51 TOPS-TO, 52 IRC) between the ages of 11-18 who were hospitalized for a moderate to severe traumatic brain injury in the previous 18 months...
August 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28829618/molecular-dynamics-simulations-of-selective-metabolite-transport-across-the-propanediol-bacterial-microcompartment-shell
#7
Jiyong Park, Sunny Chun, Thomas A Bobik, Kendall N Houk, Todd O Yeates
Bacterial microcompartments are giant protein-based organelles that encapsulate special metabolic pathways in diverse bacteria. Structural and genetic studies indicate that metabolic substrates enter these microcompartments by passing through the central pores in hexameric assemblies of shell proteins. Limiting the escape of toxic metabolic intermediates created inside the microcompartments would confer a selective advantage for the host organism. Here, we report the first molecular dynamics (MD) simulation studies to analyze small-molecule transport across a microcompartment shell...
August 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28780927/white-matter-microstructure-predicts-longitudinal-social-cognitive-outcomes-after-paediatric-traumatic-brain-injury-a-diffusion-tensor-imaging-study
#8
N P Ryan, S Genc, M H Beauchamp, K O Yeates, S Hearps, C Catroppa, V A Anderson, T J Silk
BACKGROUND: Deficits in social cognition may be among the most profound and disabling sequelae of paediatric traumatic brain injury (TBI); however, the neuroanatomical correlates of longitudinal outcomes in this domain remain unexplored. This study aimed to characterize social cognitive outcomes longitudinally after paediatric TBI, and to evaluate the use of sub-acute diffusion tensor imaging (DTI) to predict these outcomes. METHODS: The sample included 52 children with mild complex-severe TBI who were assessed on cognitive theory of mind (ToM), pragmatic language and affective ToM at 6- and 24-months post-injury...
August 7, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28757445/phylogenetics-of-australasian-gall-flies-diptera-fergusoninidae-evolutionary-patterns-of-host-shifting-and-gall-morphology
#9
S J Scheffer, K A Davies, G S Taylor, A H Thornhill, M L Lewis, I S Winkler, D K Yeates, M F Purcell, J Makinson, R M Giblin-Davis
This study investigated host-specificity and phylogenetic relationships in Australian galling flies, Fergusonina Malloch (Diptera: Fergusoninidae), in order to assess diversity and explore the evolutionary history of host plant affiliation and gall morphology. A DNA barcoding approach using COI data from 203 Fergusonina specimens from 5gall types on 56 host plant species indicated 85 presumptive fly species. These exhibited a high degree of host specificity; of the 40 species with multiple representatives, each fed only on a single host genus, 29 (72...
July 27, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28746729/pleurotus-sajor-caju-can-be-used-to-synthesize-silver-nanoparticles-with-anti-fungal-activity-against-candida-albicans
#10
Siti Fadhilah Musa, Ting Seng Yeat, Laina Zarisa Mohd Kamal, Yasser M Tabana, Mowaffaq Adam Ahmed, Ahmad El Ouweini, Lim Vuangao, Lee Chee Keong, Doblin Sandai
BACKGROUND: Green synthesis of silver nanoparticles (AgNPs) has become widely practiced worldwide. In this study, AgNPs were synthesized using a hot-water extract of the edible mushroom, Pleurotus sajor-caju. The product, PSC-AgNPs, was characterized by using UV-Vis spectra, DLS analysis, TEM, XRD and FTIR spectrometry. To assess its antifungal activity against C. albicans, gene transcription and protein expression analyses were conducted for CaICL1 and its product, ICL using RT-qPCR and western blot, respectively...
July 26, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28724466/home-environment-as-a-predictor-of-long-term-executive-functioning-following-early-childhood-traumatic-brain-injury
#11
Christianne Laliberté Durish, Keith Owen Yeates, Terry Stancin, H Gerry Taylor, Nicolay C Walz, Shari L Wade
OBJECTIVES: This study examined the relationship of the home environment to long-term executive functioning (EF) following early childhood traumatic brain injury (TBI). METHODS: Participants (N=134) were drawn from a larger parent study of 3- to 6-year-old children hospitalized for severe TBI (n=16), complicated mild/moderate TBI (n=44), or orthopedic injury (OI; n=74), recruited prospectively at four tertiary care hospitals in the United States and followed for an average of 6...
July 20, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28717721/evaluation-of-a-smartphone-based-training-strategy-among-health-care-workers-screening-for-cervical-cancer-in-northern-tanzania-the-kilimanjaro-method
#12
Karen E Yeates, Jessica Sleeth, Wilma Hopman, Ophira Ginsburg, Katharine Heus, Linda Andrews, Mary Rose Giattas, Safina Yuma, Godwin Macheku, Aziz Msuya, Olola Oneko
PURPOSE: Almost nine of 10 deaths resulting from cervical cancer occur in low-income countries. Visual inspection under acetic acid (VIA) is an evidence-based, cost-effective approach to cervical cancer screening (CCS), but challenges to effective implementation include health provider training costs, provider turnover, and skills retention. We hypothesized that a smartphone camera and use of cervical image transfer for real-time mentorship by experts located distantly across a closed user group through a commercially available smartphone application would be both feasible and effective in enhancing VIA skills among CCS providers in Tanzania...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28710227/advancing-concussion-assessment-in-pediatrics-a-cap-a-prospective-concurrent-cohort-longitudinal-study-of-mild-traumatic-brain-injury-in-children-protocol-study
#13
Keith Owen Yeates, Miriam Beauchamp, William Craig, Quynh Doan, Roger Zemek, Bruce Bjornson, Jocelyn Gravel, Angelo Mikrogianakis, Bradley Goodyear, Nishard Abdeen, Christian Beaulieu, Mathieu Dehaes, Sylvain Deschenes, Ashley Harris, Catherine Lebel, Ryan Lamont, Tyler Williamson, Karen Maria Barlow, Francois Bernier, Brian L Brooks, Carolyn Emery, Stephen B Freedman, Kristina Kowalski, Kelly Mrklas, Lianne Tomfohr-Madsen, Kathryn J Schneider
INTRODUCTION: Paediatric mild traumatic brain injury (mTBI) is a public health burden. Clinicians urgently need evidence-based guidance to manage mTBI, but gold standards for diagnosing and predicting the outcomes of mTBI are lacking. The objective of the Advancing Concussion Assessment in Pediatrics (A-CAP) study is to assess a broad pool of neurobiological and psychosocial markers to examine associations with postinjury outcomes in a large sample of children with either mTBI or orthopaedic injury (OI), with the goal of improving the diagnosis and prognostication of outcomes of paediatric mTBI...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28701360/multicentre-randomised-clinical-trial-of-paediatric-concussion-assessment-of-rest-and-exertion-pedcare-a-study-to-determine-when-to-resume-physical-activities-following-concussion-in-children
#14
Andrée-Anne Ledoux, Nicholas J Barrowman, Kathy Boutis, Adrienne Davis, Sarah Reid, Gurinder Sangha, Ken J Farion, Kevin Belanger, Mark S Tremblay, Keith Owen Yeates, Carol DeMatteo, Nick Reed, Roger Zemek
INTRODUCTION: Rest until symptom-free, followed by a progressive stepwise return to activities, is often prescribed in the management of paediatric concussions. Recent evidence suggests prolonged rest may hinder recovery, and early resumption of physical activity may be associated with more rapid recovery postconcussion. The primary objective is to determine whether the early reintroduction of non-contact physical activity beginning 72 hours postinjury reduces postconcussive symptoms at 2 weeks in children following an acute concussion as compared with a rest until asymptomatic protocol...
July 12, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28689643/suicide-means-among-decedents-aged-50-years-2005-2014-trends-and-associations-with-sociodemographic-and-precipitating-factors
#15
Namkee G Choi, Diana M DiNitto, C Nathan Marti, Mark S Kaplan, Yeates Conwell
OBJECTIVE: To examine 1) temporal trends between 2005 and 2014 in the three most frequently used suicide means (firearms, hanging/suffocation, alcohol/drug/medicine overdose) by decedents aged 50+ years and 2) associations of suicide means with sociodemographic and precipitating factors. METHODS: The National Violent Death Reporting System, 2005-2014, provided data (N = 46,857). Suicide means were identified from ICD-10 codes for underlying cause of death and coroner/medical examiner (CME) reports...
July 6, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28674683/infusion-of-sibling-marrow-in-a-patient-with-purine-nucleoside-phosphorylase-deficiency-leads-to-split-mixed-donor-chimerism-and-normal-immunity
#16
Laura Yeates, Mary A Slatter, Andrew R Gennery
Purine nucleoside phosphorylase (PNP) deficiency, a rare autosomal recessive metabolic disease causes combined immunodeficiency and developmental delay, hypotonia, and spasticity. Patients present with recurrent infections associated with T-lymphocytopenia, characteristically presenting later than patients with classical severe combined immunodeficiency (SCID). PNP, with adenosine deaminase (ADA), is part of the purine salvage pathway. The only curative therapy is hematopoietic stem cell transplantation. Myeloablative conditioning is recommended to prevent rejection caused by residual immune function...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28665690/reducing-concussion-symptoms-among-teenage-youth-evaluation-of-a-mobile-health-app
#17
Lise Worthen-Chaudhari, Jane McGonigal, Kelsey Logan, Marcia A Bockbrader, Keith O Yeates, W Jerry Mysiw
OBJECTIVE: To evaluate whether a mobile health application that employs elements of social game design could compliment medical care for unresolved concussion symptoms. DESIGN: Phase I and Phase II (open-label, non-randomized, ecological momentary assessment methodology). SETTING: Outpatient concussion clinic. PARTICIPANTS: Youth, aged 13-18 years, with concussion symptoms 3+ weeks after injury; Phase I: n = 20; Phase II: n = 19...
June 30, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28658609/postharvest-changes-in-lin5-down-regulated-plants-suggest-a-role-for-sugar-deficiency-in-cuticle-metabolism-during-ripening
#18
José G Vallarino, Trevor H Yeats, Eugenia Maximova, Jocelyn K Rose, Alisdair R Fernie, Sonia Osorio
The cell wall invertase gene (LIN5) was reported to be a key enzyme influencing sugar uptake of tomato (Solanum lycopersicum) fruit. It was additionally revealed to be a key regulator of total soluble solids content in fruit as well as for reproductive development, being mainly involved in flower development, early fruit and seed development but also in ripening. Here, we demonstrate that silencing of the LIN5 gene promotes changes affecting fruit cuticle development which has a direct effect on postharvest properties...
October 2017: Phytochemistry
https://www.readbyqxmd.com/read/28627915/long-term-classroom-functioning-and-its-association-with-neuropsychological-and-academic-performance-following-traumatic-brain-injury-during-early-childhood
#19
Amery Treble-Barna, Hanna Schultz, Nori Minich, H Gerry Taylor, Keith Owen Yeates, Terry Stancin, Shari L Wade
OBJECTIVE: The present study utilized ecobehavioral assessment to examine classroom functioning several years following early childhood traumatic brain injury (TBI) or orthopedic injury (OI) and its association with injury factors, neuropsychological abilities, and academic performance. METHOD: Participants included 39 children with moderate to severe TBI and 51 children with OI sustained between ages 3 and 7 years. At 7.2 (± 1.3) years post injury, ecobehavioral assessment was used to examine classroom functioning...
July 2017: Neuropsychology
https://www.readbyqxmd.com/read/28594412/attitudes-knowledge-and-consequences-of-uncertain-genetic-findings-in-hypertrophic-cardiomyopathy
#20
Charlotte Burns, Laura Yeates, Catherine Spinks, Christopher Semsarian, Jodie Ingles
With the surge of next-generation sequencing (NGS) technologies making almost all genetic tests more affordable and available, cardiac genetic testing now routinely encompasses a large number of genes within a panel setting. The additional sensitivity of this practice is limited and has the potential to inflict a spectrum of uncertainty. We sought to explore attitudes, preferences, recall and psychological consequences of informative and uninformative genetic results amongst probands diagnosed with hypertrophic cardiomyopathy (HCM)...
June 2017: European Journal of Human Genetics: EJHG
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