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https://www.readbyqxmd.com/read/27931255/wealth-and-cardiovascular-health-a-cross-sectional-study-of-wealth-related-inequalities-in-the-awareness-treatment-and-control-of-hypertension-in-high-middle-and-low-income-countries
#1
Benjamin Palafox, Martin McKee, Dina Balabanova, Khalid F AlHabib, Alvaro Jr Avezum, Ahmad Bahonar, Noorhassim Ismail, Jephat Chifamba, Clara K Chow, Daniel J Corsi, Gilles R Dagenais, Rafael Diaz, Rajeev Gupta, Romaina Iqbal, Manmeet Kaur, Rasha Khatib, Annamarie Kruger, Iolanthe Marike Kruger, Fernando Lanas, Patricio Lopez-Jaramillo, Fu Minfan, Viswanathan Mohan, Prem K Mony, Aytekin Oguz, Lia M Palileo-Villanueva, Pablo Perel, Paul Poirier, Sumathy Rangarajan, Lei Rensheng, Annika Rosengren, Biju Soman, David Stuckler, S V Subramanian, Koon Teo, Lungiswa P Tsolekile, Andreas Wielgosz, Peng Yaguang, Karen Yeates, Mo Yongzhen, Khalid Yusoff, Rita Yusuf, Afzalhussein Yusufali, Katarzyna Zatońska, Salim Yusuf
BACKGROUND: Effective policies to control hypertension require an understanding of its distribution in the population and the barriers people face along the pathway from detection through to treatment and control. One key factor is household wealth, which may enable or limit a household's ability to access health care services and adequately control such a chronic condition. This study aims to describe the scale and patterns of wealth-related inequalities in the awareness, treatment and control of hypertension in 21 countries using baseline data from the Prospective Urban and Rural Epidemiology study...
December 8, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27897083/hawks-doves-and-rasch-decisions-understanding-the-influence-of-different-cycles-of-an-osce-on-students-scores-using-many-facet-rasch-modeling
#2
Peter Yeates, Stefanie S Sebok-Syer
INTRODUCTION: OSCEs are commonly conducted in multiple cycles (different circuits, times, and locations), yet the potential for students' allocation to different OSCE cycles is rarely considered as a source of variance-perhaps in part because conventional psychometrics provide limited insight. METHODS: We used Many Facet Rasch Modeling (MFRM) to estimate the influence of "examiner cohorts" (the combined influence of the examiners in the cycle to which each student was allocated) on students' scores within a fully nested multi-cycle OSCE...
November 29, 2016: Medical Teacher
https://www.readbyqxmd.com/read/27892612/the-prevalence-of-depressive-symptoms-among-older-patients-with-hypertension-in-rural-china
#3
Jiang Xue, Shulin Chen, Hillary R Bogner, Wan Tang, Lydia Li, Yeates Conwell
OBJECTIVE: The comorbidity of depression and hypertension (HTN) is common and complicates the management of both conditions. This study investigated the prevalence of depressive symptoms among older patients with HTN in rural China and explored the relationship between the two conditions. METHODS: The baseline data of older patients diagnosed with HTN included in the depression/HTN in Chinese Older Adults-Collaborations for Health Study were used for the analysis...
November 28, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27889283/suicidal-ideation-and-social-capital-community-matters
#4
EDITORIAL
Adam Simning, Yeates Conwell
No abstract text is available yet for this article.
November 8, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27886793/innovative-approaches-to-hypertension-control-in-low-and-middle-income-countries
#5
REVIEW
Rajesh Vedanthan, Antonio Bernabe-Ortiz, Omarys I Herasme, Rohina Joshi, Patricio Lopez-Jaramillo, Amanda G Thrift, Jacqui Webster, Ruth Webster, Karen Yeates, Joyce Gyamfi, Merina Ieremia, Claire Johnson, Jemima H Kamano, Maria Lazo-Porras, Felix Limbani, Peter Liu, Tara McCready, J Jaime Miranda, Sailesh Mohan, Olugbenga Ogedegbe, Brian Oldenburg, Bruce Ovbiagele, Mayowa Owolabi, David Peiris, Vilarmina Ponce-Lucero, Devarsetty Praveen, Arti Pillay, Jon-David Schwalm, Sheldon W Tobe, Kathy Trieu, Khalid Yusoff, Valentin Fuster
Elevated blood pressure, a major risk factor for ischemic heart disease, heart failure, and stroke, is the leading global risk for mortality. Treatment and control rates are very low in low- and middle-income countries. There is an urgent need to address this problem. The Global Alliance for Chronic Diseases sponsored research projects focus on controlling hypertension, including community engagement, salt reduction, salt substitution, task redistribution, mHealth, and fixed-dose combination therapies. This paper reviews the rationale for each approach and summarizes the experience of some of the research teams...
February 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/27886219/elderly-suicide-trends-in-the-context-of-transforming-china-1987-2014
#6
Bao-Liang Zhong, Helen F K Chiu, Yeates Conwell
In the context of rapid ageing, understanding the time-trend of elderly suicide (ES) could inform China's efforts on suicide prevention. We examined time-trends in Chinese ES rates (ESRs) from 1987 to 2014, a period of profound social changes. Suicide rates by residence (rural/urban), gender, and 5-year age-group (65+) in 1987-2014 were provided by the Chinese Ministry of Health. Time-trends were analyzed with joinpoint analysis. The time-trend of national ESRs was downward (average annual percent change [AAPC] = -3...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27855727/iodine-knowledge-is-positively-associated-with-dietary-iodine-intake-among-women-of-childbearing-age-in-the-uk-and-ireland
#7
S Maria O'Kane, L Kirsty Pourshahidi, Kayla M Farren, Maria S Mulhern, J J Strain, Alison J Yeates
Adequate I intake is important before conception and during pregnancy for optimal infant neurodevelopment. Recent studies have highlighted the prevalence of I deficiency in the UK and Ireland. It is possible that optimal I intake may be impeded by a poor knowledge of I nutrition. This study aimed to investigate I knowledge among women of childbearing age in the UK and Ireland and to determine whether a relationship exists between I knowledge and dietary I intake. Females (aged 18-45 years) were invited to complete an online questionnaire, which assessed knowledge of I and estimated dietary I intake using a FFQ...
November 18, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27814965/the-global-burden-of-women-s-cancers-a-grand-challenge-in-global-health
#8
REVIEW
Ophira Ginsburg, Freddie Bray, Michel P Coleman, Verna Vanderpuye, Alexandru Eniu, S Rani Kotha, Malabika Sarker, Tran Thanh Huong, Claudia Allemani, Allison Dvaladze, Julie Gralow, Karen Yeates, Carolyn Taylor, Nandini Oomman, Suneeta Krishnan, Richard Sullivan, Dominista Kombe, Magaly M Blas, Groesbeck Parham, Natasha Kassami, Lesong Conteh
Every year, more than 2 million women worldwide are diagnosed with breast or cervical cancer, yet where a woman lives, her socioeconomic status, and agency largely determines whether she will develop one of these cancers and will ultimately survive. In regions with scarce resources, fragile or fragmented health systems, cancer contributes to the cycle of poverty. Proven and cost-effective interventions are available for both these common cancers, yet for so many women access to these is beyond reach. These inequities highlight the urgent need in low-income and middle-income countries for sustainable investments in the entire continuum of cancer control, from prevention to palliative care, and in the development of high-quality population-based cancer registries...
November 1, 2016: Lancet
https://www.readbyqxmd.com/read/27814963/interventions-to-close-the-divide-for-women-with-breast-and-cervical-cancer-between-low-income-and-middle-income-countries-and-high-income-countries
#9
REVIEW
Lynette Denny, Silvia de Sanjose, Miriam Mutebi, Benjamin O Anderson, Jane Kim, Jose Jeronimo, Rolando Herrero, Karen Yeates, Ophira Ginsburg, Rengaswamy Sankaranarayanan
Breast and cervical cancers are the commonest cancers diagnosed in women living in low-income and middle-income countries (LMICs), where opportunities for prevention, early detection, or both, are few. Yet several cost-effective interventions could be used to reduce the burden of these two cancers in resource-limited environments. Population- wide vaccination against human papillomavirus (HPV) linked to cervical screening, at least once, for adult women has the potential to reduce the incidence of cervical cancer substantially...
November 1, 2016: Lancet
https://www.readbyqxmd.com/read/27809667/social-and-behavioral-outcomes-following-traumatic-brain-injury-what-predicts-outcome-at-12-months-post-insult
#10
Cathy Catroppa, Stephen J C Hearps, Louise Crossley, Keith Owen Yeates, Miriam Helen Beauchamp, Jessica Fussela, Vicki Anderson
This study sought to investigate social and behavioral outcomes 12 months following childhood traumatic brain injury (TBI) and to identify predictors of these outcomes. The study also compared rates of impairment in social and behavioral outcomes at 12 months post-injury between children with TBI and a typically developing (TD) control group. The study comprised 114 children ages 5.5 to 16 years, 79 with mild, moderate, or severe TBI and 35 TD children, group-matched for age, sex and SES. Children with TBI were recruited via consecutive hospital admissions and TD children from the community...
November 3, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27800147/the-role-of-isocitrate-lyase-icl1-in-the-metabolic-adaptation-of-candida-albicans-biofilms
#11
Oluwaseun Ayodeji Ishola, Seng Yeat Ting, Yasser M Tabana, Mowaffaq Adam Ahmed, Muhammad Amir Yunus, Rafeezul Mohamed, Leslie Thian Lung Than, Doblin Sandai
BACKGROUND: A major characteristic of Candida biofilm cells that differentiates them from free-floating cells is their high tolerance to antifungal drugs. This high resistance is attributed to particular biofilm properties, including the accumulation of extrapolymeric substances, morphogenetic switching, and metabolic flexibility. OBJECTIVES: This study evaluated the roles of metabolic processes (in particular the glyoxylate cycle) on biofilm formation, antifungal drug resistance, morphology, and cell wall components...
September 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27786528/observed-parent-behaviors-as-time-varying-moderators-of-problem-behaviors-following-traumatic-brain-injury-in-young-children
#12
Amery Treble-Barna, Huaiyu Zang, Nanhua Zhang, H Gerry Taylor, Terry Stancin, Keith Owen Yeates, Shari L Wade
Parent behaviors moderate the adverse consequences of pediatric traumatic brain injury (TBI); however, it is unknown how these moderating effects change over time. This study examined the moderating effect of observed parent behaviors over time since injury on the relation between TBI and behavioral outcomes. Participants included children, ages 3-7 years, hospitalized for moderate (n = 52) or severe (n = 20) TBI or orthopedic injury (OI; n = 95). Parent-child dyads were videotaped during structured task and free play conditions, and parents completed child behavior ratings...
November 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27779719/downregulation-of-yeats4-by-mir-218-sensitizes-colorectal-cancer-cells-to-l-ohp-induced-cell-apoptosis-by-inhibiting-cytoprotective-autophagy
#13
Qiang Fu, Jing Cheng, Jindai Zhang, Yonglei Zhang, Xiaobing Chen, Jianguo Xie, Suxia Luo
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Deregulation of microRNAs (miRNAs) has been reported to participate in CRC progression. In the present study, we observed downregulation of miR-218 and upregulation of YEATS domain containing 4 (YEATS4) in CRC tissues and in multidrug-resistant HCT-116/L-OHP cells compared with these levels in normal tissues and parental HCT-116 cells, respectively. The results indicated that miR-218 overexpression significantly decreased the IC50 value of oxaliplatin (L-OHP) in the HCT-116/L-OHP cells, and suppression of miR-218 significantly enhanced the IC50 of L-OHP in the HCT-116 cells...
October 21, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27775762/association-of-persistent-postconcussion-symptoms-with-pediatric-quality-of-life
#14
Zuzana Novak, Mary Aglipay, Nick Barrowman, Keith O Yeates, Miriam H Beauchamp, Jocelyn Gravel, Stephen B Freedman, Isabelle Gagnon, Gerard Gioia, Kathy Boutis, Emma Burns, Andrée-Anne Ledoux, Martin H Osmond, Roger L Zemek
Importance: Persistent postconcussion symptoms (PPCS) pose long-term challenges and can negatively affect patients' health-related quality of life (HRQoL). To date, no large comprehensive study has addressed the association between PPCS and HRQoL. Objectives: To determine the association between HRQoL and PPCS at 4 weeks after concussion and assess the degree of impairment of HRQoL in the subsequent 12 weeks. Design, Setting, and Participants: In a prospective, multicenter cohort study (Predicting Persistent Postconcussive Problems in Pediatrics [5P]) from August 14, 2013, to September 30, 2014, children aged 5 to 18 years who presented to the emergency department within 48 hours after head injury and were considered to have an acute concussion were enrolled across 9 pediatric emergency departments within the Pediatric Emergency Research Canada Network...
December 5, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27689977/group-i-intron-internal-guide-sequence-binding-strength-as-a-component-of-ribozyme-network-formation
#15
Laura Elizabeth Satterwhite, Jessica A M Yeates, Niles Lehman
Origins-of-life research requires searching for a plausible transition from simple chemicals to larger macromolecules that can both hold information and catalyze their own production. We have previously shown that some group I intron ribozymes possess the ability to help synthesize other ribozyme genotypes by recombination reactions in small networks in an autocatalytic fashion. By simplifying these recombination reactions, using fluorescent anisotropy, we quantified the thermodynamic binding strength between two nucleotides of two group I intron RNA fragments for all 16 possible genotype combinations...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27661789/yeats-domain-linking-histone-crotonylation-to-gene-regulation
#16
Yuanyuan Li, Dan Zhao, Zhonglei Chen, Haitao Li
Recent research reveals that the YEATS domains preferentially recognize crotonylated lysines on histones. Here, we discuss the molecular mechanisms that enable this recognition and the biological significances of this interaction. The dynamics of histone crotonylation and its potential roles in the regulation of gene expression will also be discussed.
September 23, 2016: Transcription
https://www.readbyqxmd.com/read/27650475/disability-in-prison-activities-of-daily-living-and-likelihood-of-depression-and-suicidal-ideation-in-older-prisoners
#17
Lisa C Barry, Dorothy B Wakefield, Robert L Trestman, Yeates Conwell
OBJECTIVE: The study objective was to determine if disability in activities of daily living specific to prison, prison activities of daily living (PADLs), is associated with depression and severity of suicidal ideation (SI) in older prisoners, a rapidly growing population at high risk of suicide. METHODS: Cross-sectional design using data from a study of prisoners age ≥50 years (N = 167). Depression was operationalized as a score of ≥15 on the 9-item Physician Health Questionnaire (PHQ-9)...
September 21, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27639861/rates-and-characteristics-of-elderly-suicide-in-china-2013-14
#18
Bao-Liang Zhong, Helen F K Chiu, Yeates Conwell
BACKGROUND: The number of older adults (OAs) is growing rapidly and the elderly suicide rate (ESR) is highest among all age-groups in China. Examining the epidemiology of elderly suicide (ES) may facilitate population-specific suicide prevention efforts, however, little is known about the patterns of ES in China. OBJECTIVE: To describe the rates and characteristics of ES in China during 2013-14. METHODS: Suicide mortality data by gender, quinquennial age-group, residence (urban/rural) and geographic location (east/central/west) were obtained from China's Integrated National Mortality Surveillance System for 2013-14...
September 13, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27633324/maternal-and-paternal-distress-and-coping-over-time-following-pediatric-traumatic-brain-injury
#19
Megan E Narad, Keith O Yeates, H Gerry Taylor, Terry Stancin, Shari L Wade
OBJECTIVE : Examine differences in maternal and paternal coping and distress following traumatic brain injury (TBI) and orthopedic injuries (OI).  METHOD : Concurrent cohort/prospective design with five assessments between 1 and an average of 7 years after injury of children aged 3-6 years hospitalized for TBI (n = 87) or OI (n = 119). Mixed models analyses were used to examine hypotheses. RESULTS : Overall, fathers reported greater depression and general distress than mothers 18 months after injury, but not at long-term follow-up...
September 15, 2016: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/27610048/challenges-associated-with-managing-suicide-risk-in-long-term-care-facilities
#20
Alisa O'Riley, Michael R Nadorff, Yeates Conwell, Barry Edelstein
Little information about suicidal ideation and behavior in long-term care (LTC) facilities is available. Nonetheless, the implementation of the Minimum Data Set 3.0 requires that LTC facilities screen their residents for suicide risk and have protocols in place to effectively manage residents' responses. In this article, the authors briefly discuss the risk factors of suicide in the elderly and the problems that suicidal ideation and behavior pose in the LTC environment. The authors explain issues that arise when trying to manage suicide risk in the elderly LTC population with general, traditional approaches...
June 2013: Annals of Long-term Care: the Official Journal of the American Medical Directors Association
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