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https://www.readbyqxmd.com/read/29326842/barriers-to-peritoneal-dialysis-in-aboriginal-patients
#1
Anna T Mathew, Joonho Park, Mala Sachdeva, Manish M Sood, Karen Yeates
Background: Aboriginal people in Canada have an unduly high burden of end-stage kidney disease (ESKD) and many live in rural settings. Peritoneal dialysis (PD) is a home-based dialysis modality that may provide a valuable alternative to in-center hemodialysis which is relatively underutilized by the Aboriginal population. Objective: We aim to assess the barriers to PD utilization in Aboriginal patients with ESKD. Design: This article is a prospective observational cohort study...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29258978/the-effectiveness-of-text-messaging-for-detection-and-management-of-hypertension-in-indigenous-people-in-canada-protocol-for-a-randomized-controlled-trial
#2
Karen Yeates, Norm Campbell, Marion A Maar, Nancy Perkins, Peter Liu, Jessica Sleeth, Carter Smith, Colin McAllister, Diane Hua-Stewart, George Wells, Sheldon W Tobe
BACKGROUND: Hypertension, the leading cause of morbidity and mortality, affects more than 1 billion people and is responsible globally for 10 million deaths annually. Hypertension can be controlled on a national level; in Canada, for example, awareness, treatment, and control improved dramatically from only 16% in 1990 to 66% currently. The ongoing development, dissemination, and implementation of Hypertension Canada's clinical practice guidelines is considered to be responsible, in part, for achieving these high levels of control and the associated improvements in cardiovascular outcomes...
December 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29249313/in-silico-identification-and-high-throughput-screening-of-antigenic-proteins-as-candidates-for-a-mannheimia-haemolytica-vaccine
#3
Cassidy L Klima, Rahat Zaheer, Shaun R Cook, Jay Rasmussen, Trevor W Alexander, Andrew Potter, Steve Hendrick, Tim A McAllister
This study examined the use of comparative genomic analysis for vaccine design against Mannheimia haemolytica, a respiratory pathogen of ruminants. A total of 2,341genes were identified in at least half of the 23 genomes. Of these, a total of 240 were identified to code for N-terminal signal peptides with diverse sub-cellular localizations (78 periplasmic, 52 outer membrane, 15 extracellular, 13 cytoplasmic membrane and 82 unknown) and were examined in an ELISA assay using a coupled-cell free transcription/translation system for protein expressionwith antisera from cattle challenged with serovars 1, 2 or 6 of M...
January 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29217648/the-interaction-of-enl-with-paf1-mitigates-polycomb-silencing-and-facilitates-murine-leukemogenesis
#4
Katrin Hetzner, Maria-Paz Garcia-Cuellar, Christian Büttner, Robert K Slany
ENL is a chromatin reader present in complexes stimulating transcriptional elongation. It is fused to MLL in leukemia and missense mutations have been identified in Wilms' tumor and AML. Here we demonstrate that ENL overcomes polycomb silencing through recruitment of PAF1 via the conserved YEATS domain that recognizes acetylated histone H3. PAF1 was responsible for anti-repressive activities of ENL in vitro and it determined the transforming potential of MLL-ENL. MLL-ENL target loci showed supraphysiological PAF1 binding, hyper-ubiquitination of histone H2B and hypomodification with H2AUb resulting in accelerated transcription rates...
December 7, 2017: Blood
https://www.readbyqxmd.com/read/29217555/putting-the-rubisco-pieces-together
#5
Todd O Yeates, Nicole M Wheatley
No abstract text is available yet for this article.
December 8, 2017: Science
https://www.readbyqxmd.com/read/29207908/a-scoping-review-of-pain-in-children-following-traumatic-brain-injury-is-there-more-than-headache
#6
Vivian Kwan, Mai Vo, Melanie Noel, Keith Owen Yeates
AIM: Headache is a common source of pain in children following traumatic brain injury (TBI); however, relatively little is known about non-headache pain in this pediatric population. The present review seeks to map the extant literature to determine the prevalence, characteristics, and impact of non-headache pain in children following TBI of all severities. RESULTS: Of 109 studies published on pain in children following a TBI, 95 (87%) were focused exclusively on headache pain and only 14 (13%) reported on non-headache pain or overall pain, with half (n = 7) in the form of case studies...
December 5, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29205936/facile-methods-for-heterologous-production-of-bacterial-microcompartments-in-diverse-host-species
#7
Todd O Yeates, Thomas A Bobik
No abstract text is available yet for this article.
December 4, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29198271/the-neuropsychology-of-traumatic-brain-injury-looking-back-peering-ahead
#8
Keith Owen Yeates, Harvey S Levin, Jennie Ponsford
The past 50 years have been a period of exciting progress in neuropsychological research on traumatic brain injury (TBI). Neuropsychologists and neuropsychological testing have played a critical role in these advances. This study looks back at three major scientific advances in research on TBI that have been critical in pushing the field forward over the past several decades: The advent of modern neuroimaging; the recognition of the importance of non-injury factors in determining recovery from TBI; and the growth of cognitive rehabilitation...
October 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29192288/optical-charge-state-control-of-spin-defects-in-4h-sic
#9
Gary Wolfowicz, Christopher P Anderson, Andrew L Yeats, Samuel J Whiteley, Jens Niklas, Oleg G Poluektov, F Joseph Heremans, David D Awschalom
Defects in silicon carbide (SiC) have emerged as a favorable platform for optically active spin-based quantum technologies. Spin qubits exist in specific charge states of these defects, where the ability to control these states can provide enhanced spin-dependent readout and long-term charge stability. We investigate this charge state control for two major spin qubits in 4H-SiC, the divacancy and silicon vacancy, obtaining bidirectional optical charge conversion between the bright and dark states of these defects...
November 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/29145630/yaf9-subunit-of-the-nua4-and-swr1-complexes-targets-histone-h3k27ac-through-its-yeats-domain
#10
Brianna J Klein, Salar Ahmad, Kendra R Vann, Forest H Andrews, Zachary A Mayo, Gaelle Bourriquen, Joseph B Bridgers, Jinyong Zhang, Brian D Strahl, Jacques Côté, Tatiana G Kutateladze
Yaf9 is an integral part of the NuA4 acetyltransferase and the SWR1 chromatin remodeling complexes. Here, we show that Yaf9 associates with acetylated histone H3 with high preference for H3K27ac. The crystal structure of the Yaf9 YEATS domain bound to the H3K27ac peptide reveals that the sequence C-terminal to K27ac stabilizes the complex. The side chain of K27ac inserts between two aromatic residues, mutation of which abrogates the interaction in vitro and leads in vivo to phenotypes similar to YAF9 deletion, including loss of SWR1-dependent incorporation of variant histone H2A...
November 14, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29137132/maternal-vitamin-d-status-and-the-relationship-with-neonatal-anthropometric-and-childhood-neurodevelopmental-outcomes-results-from-the-seychelles-child-development-nutrition-study
#11
Eamon Laird, Sally W Thurston, Edwin van Wijngaarden, Conrad F Shamlaye, Gary J Myers, Philip W Davidson, Gene E Watson, Emeir M McSorley, Maria S Mulhern, Alison J Yeates, Mary Ward, Helene McNulty, J J Strain
Vitamin D has an important role in early life; however, the optimal vitamin D status during pregnancy is currently unclear. There have been recent calls for pregnant women to maintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yet little is known about the long-term potential benefits or safety of achieving such high maternal 25(OH)D concentrations for infant or child health outcomes. We examined maternal vitamin D status and its associations with infant anthropometric and later childhood neurocognitive outcomes in a mother-child cohort in a sun-rich country near the equator (4...
November 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29121973/in-vitro-investigations-on-extracellular-proteins-secreted-by-aphanomyces-invadans-the-causative-agent-of-epizootic-ulcerative-syndrome
#12
Muhammad Majeed, Gokhlesh Kumar, Sarah Schlosser, Mansour El-Matbouli, Mona Saleh
BACKGROUND: Proteases produced by many microorganisms, including oomycetes, are crucial for their growth and development. They may also play a critical role in disease manifestation. Epizootic ulcerative syndrome is one of the most destructive fish diseases known. It is caused by the oomycete Aphanomyces invadans and leads to mass mortalities of cultured and wild fish in many countries. The areas of concern are Australia, China, Japan, South and Southeast Asian countries and the USA. Extracellular proteases produced by this oomycete are believed to trigger EUS pathogenesis in fish...
November 9, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29096775/randomized-clinical-trial-of-online-parent-training-for-behavior-problems-after-early-brain-injury
#13
Shari L Wade, Amy E Cassedy, Emily L Shultz, Huaiyu Zang, Nanhua Zhang, Michael W Kirkwood, Terry Stancin, Keith O Yeates, H Gerry Taylor
OBJECTIVE: To evaluate the effectiveness of Internet-based Interacting Together Everyday: Recovery After Childhood TBI (I-InTERACT) versus abbreviated parent training (Express) or access to online resources (internet resources comparison [IRC]) in improving parenting skills and decreasing behavior problems after early traumatic brain injury (TBI). METHOD: In this randomized, controlled, clinical trial, 113 children 3 to 9 years old previously hospitalized for moderate to severe TBI were randomly assigned to receive Express (n = 36), I-InTERACT (n = 39), or IRC (n = 38)...
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29076889/online-problem-solving-for-adolescent-brain-injury-a-randomized-trial-of-2-approaches
#14
Shari L Wade, Hudson Gerry Taylor, Keith Owen Yeates, Michael Kirkwood, Huaiyu Zang, Kelly McNally, Terry Stacin, Nanhua Zhang
OBJECTIVE: Adolescent traumatic brain injury (TBI) contributes to deficits in executive functioning and behavior, but few evidence-based treatments exist. We conducted a randomized clinical trial comparing Teen Online Problem Solving with Family (TOPS-Family) with Teen Online Problem Solving with Teen Only (TOPS-TO) or the access to Internet Resources Comparison (IRC) group. METHODS: Children, aged 11 to 18 years, who sustained a complicated mild-to-severe TBI in the previous 18 months were randomly assigned to the TOPS-Family (49), TOPS-TO (51), or IRC group (52)...
October 27, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29065875/a-randomised-trial-of-the-influence-of-racial-stereotype-bias-on-examiners-scores-feedback-and-recollections-in-undergraduate-clinical-exams
#15
Peter Yeates, Katherine Woolf, Emyr Benbow, Ben Davies, Mairhead Boohan, Kevin Eva
BACKGROUND: Asian medical students and doctors receive lower scores on average than their white counterparts in examinations in the UK and internationally (a phenomenon known as "differential attainment"). This could be due to examiner bias or to social, psychological or cultural influences on learning or performance. We investigated whether students' scores or feedback show influence of ethnicity-related bias; whether examiners unconsciously bring to mind (activate) stereotypes when judging Asian students' performance; whether activation depends on the stereotypicality of students' performances; and whether stereotypes influence examiner memories of performances...
October 25, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29057918/yeats2-links-histone-acetylation-to-tumorigenesis-of-non-small-cell-lung-cancer
#16
Wenyi Mi, Haipeng Guan, Jie Lyu, Dan Zhao, Yuanxin Xi, Shiming Jiang, Forest H Andrews, Xiaolu Wang, Mihai Gagea, Hong Wen, Laszlo Tora, Sharon Y R Dent, Tatiana G Kutateladze, Wei Li, Haitao Li, Xiaobing Shi
Recognition of modified histones by "reader" proteins constitutes a key mechanism regulating diverse chromatin-associated processes important for normal and neoplastic development. We recently identified the YEATS domain as a novel acetyllysine-binding module; however, the functional importance of YEATS domain-containing proteins in human cancer remains largely unknown. Here, we show that the YEATS2 gene is highly amplified in human non-small cell lung cancer (NSCLC) and is required for cancer cell growth and survival...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29051541/helicity-dependent-photocurrent-in-electrically-gated-bi1-x-sb-x-2te3-thin-films
#17
Yu Pan, Qing-Ze Wang, Andrew L Yeats, Timothy Pillsbury, Thomas C Flanagan, Anthony Richardella, Haijun Zhang, David D Awschalom, Chao-Xing Liu, Nitin Samarth
Circularly polarized photons are known to generate a directional helicity-dependent photocurrent in three-dimensional topological insulators at room temperature. Surprisingly, the phenomenon is readily observed at photon energies that excite electrons to states far above the spin-momentum locked Dirac cone and the underlying mechanism for the helicity-dependent photocurrent is still not understood. Here we show a comprehensive study of the helicity-dependent photocurrent in (Bi1-x Sb x )2Te3 thin films as a function of the incidence angle of the optical excitation, its wavelength and the gate-tuned chemical potential...
October 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29048277/retrospective-observational-study-of-atypical-winter-respiratory-illness-season-using-real-time-syndromic-surveillance-england-2014-15
#18
Sue Smith, Roger Morbey, Richard G Pebody, Thomas C Hughes, Simon de Lusignan, F Alex Yeates, Helen Thomas, Sarah J O'Brien, Gillian E Smith, Alex J Elliot
During winter 2014-15, England experienced severe strains on acute health services. We investigated whether syndromic surveillance could contribute to understanding of the unusually high level of healthcare needs. We compared trends for several respiratory syndromic indicators from that winter to historical baselines. Cumulative and mean incidence rates were compared by winter and age group. All-age influenza-like illness was at expected levels; however, severe asthma and pneumonia levels were above those expected...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29037751/discrimination-and-risk-for-suicide-in-later-life
#19
EDITORIAL
Yeates Conwell
No abstract text is available yet for this article.
September 20, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28988864/museum-genomics-confirms-that-the-lord-howe-island-stick-insect-survived-extinction
#20
Alexander S Mikheyev, Andreas Zwick, Michael J L Magrath, Miguel L Grau, Lijun Qiu, You Ning Su, David Yeates
The Lord Howe Island stick insect, Dryococelus australis, was once common on the island but was driven to extinction after the arrival of ship rats in the early 20th century [1, 2]. It was thought to be extinct for decades, until a tiny population of similar-looking stick insects was discovered 20 km away, on the islet of Ball's Pyramid, in 2001 [2]. Individuals from this population are currently being reared in Australia and elsewhere in the world, with the eventual goal of recolonizing Lord Howe Island [3]...
October 23, 2017: Current Biology: CB
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