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https://www.readbyqxmd.com/read/29776807/public-health-surveillance-of-multidrug-resistant-clones-of-neisseria-gonorrhoeae-in-europe-a-genomic-survey
#1
Simon R Harris, Michelle J Cole, Gianfranco Spiteri, Leonor Sánchez-Busó, Daniel Golparian, Susanne Jacobsson, Richard Goater, Khalil Abudahab, Corin A Yeats, Beatrice Bercot, Maria José Borrego, Brendan Crowley, Paola Stefanelli, Francesco Tripodo, Raquel Abad, David M Aanensen, Magnus Unemo
BACKGROUND: Traditional methods for molecular epidemiology of Neisseria gonorrhoeae are suboptimal. Whole-genome sequencing (WGS) offers ideal resolution to describe population dynamics and to predict and infer transmission of antimicrobial resistance, and can enhance infection control through linkage with epidemiological data. We used WGS, in conjunction with linked epidemiological and phenotypic data, to describe the gonococcal population in 20 European countries. We aimed to detail changes in phenotypic antimicrobial resistance levels (and the reasons for these changes) and strain distribution (with a focus on antimicrobial resistance strains in risk groups), and to predict antimicrobial resistance from WGS data...
May 15, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29755943/holt-oram-syndrome-in-two-families-diagnosed-with-left-ventricular-noncompaction-and-conduction-disease
#2
Samantha Barratt Ross, Richard D Bagnall, Laura Yeates, Raymond W Sy, Christopher Semsarian
No abstract text is available yet for this article.
April 2018: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/29717712/microfocus-diffraction-from-different-regions-of-a-protein-crystal-structural-variations-and-unit-cell-polymorphism
#3
Michael C Thompson, Duilio Cascio, Todd O Yeates
Real macromolecular crystals can be non-ideal in a myriad of ways. This often creates challenges for structure determination, while also offering opportunities for greater insight into the crystalline state and the dynamic behavior of macromolecules. To evaluate whether different parts of a single crystal of a dynamic protein, EutL, might be informative about crystal and protein polymorphism, a microfocus X-ray synchrotron beam was used to collect a series of 18 separate data sets from non-overlapping regions of the same crystal specimen...
May 1, 2018: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/29717691/probability-of-major-depression-diagnostic-classification-using-semi-structured-versus-fully-structured-diagnostic-interviews
#4
Brooke Levis, Andrea Benedetti, Kira E Riehm, Nazanin Saadat, Alexander W Levis, Marleine Azar, Danielle B Rice, Matthew J Chiovitti, Tatiana A Sanchez, Pim Cuijpers, Simon Gilbody, John P A Ioannidis, Lorie A Kloda, Dean McMillan, Scott B Patten, Ian Shrier, Russell J Steele, Roy C Ziegelstein, Dickens H Akena, Bruce Arroll, Liat Ayalon, Hamid R Baradaran, Murray Baron, Anna Beraldi, Charles H Bombardier, Peter Butterworth, Gregory Carter, Marcos H Chagas, Juliana C N Chan, Rushina Cholera, Neerja Chowdhary, Kerrie Clover, Yeates Conwell, Janneke M de Man-van Ginkel, Jaime Delgadillo, Jesse R Fann, Felix H Fischer, Benjamin Fischler, Daniel Fung, Bizu Gelaye, Felicity Goodyear-Smith, Catherine G Greeno, Brian J Hall, John Hambridge, Patricia A Harrison, Ulrich Hegerl, Leanne Hides, Stevan E Hobfoll, Marie Hudson, Thomas Hyphantis, Masatoshi Inagaki, Khalida Ismail, Nathalie Jetté, Mohammad E Khamseh, Kim M Kiely, Femke Lamers, Shen-Ing Liu, Manote Lotrakul, Sonia R Loureiro, Bernd Löwe, Laura Marsh, Anthony McGuire, Sherina Mohd Sidik, Tiago N Munhoz, Kumiko Muramatsu, Flávia L Osório, Vikram Patel, Brian W Pence, Philippe Persoons, Angelo Picardi, Alasdair G Rooney, Iná S Santos, Juwita Shaaban, Abbey Sidebottom, Adam Simning, Lesley Stafford, Sharon Sung, Pei Lin Lynnette Tan, Alyna Turner, Christina M van der Feltz-Cornelis, Henk C van Weert, Paul A Vöhringer, Jennifer White, Mary A Whooley, Kirsty Winkley, Mitsuhiko Yamada, Yuying Zhang, Brett D Thombs
BACKGROUND: Different diagnostic interviews are used as reference standards for major depression classification in research. Semi-structured interviews involve clinical judgement, whereas fully structured interviews are completely scripted. The Mini International Neuropsychiatric Interview (MINI), a brief fully structured interview, is also sometimes used. It is not known whether interview method is associated with probability of major depression classification.AimsTo evaluate the association between interview method and odds of major depression classification, controlling for depressive symptom scores and participant characteristics...
June 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29717643/the-national-institute-of-neurological-disorders-and-stroke-and-department-of-defense-sport-related-concussion-common-data-elements-version-1-0-recommendations
#5
Steven P Broglio, Anthony P Kontos, Harvey Levin, Kathryn Schneider, Elisabeth A Wilde, Robert C Cantu, Nina Feddermann-Demont, Gordon Fuller, Isabelle Gagnon, Gerry Gioia, Christopher C Giza, Grace Sophia Griesbach, John J Leddy, Michael L Lipton, Andrew Mayer, Thomas McAllister, Michael McCrea, Lara McKenzie, Margot Putukian, Stefano Signoretti, Stacy J Suskauer, Robert Tamburro, Michael Turner, Keith Owen Yeates, Roger Zemek, Sherita Ala'i, Joy Esterlitz, Katelyn Gay, Patrick S F Bellgowan, Kristen Joseph
AIM: Through a partnership with the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), and Department of Defense (DoD), the development of Sport-Related Concussion (SRC) Common Data Elements (CDEs) was initiated. The aim of this collaboration was to increase the efficiency and effectiveness of clinical research studies and clinical treatment outcomes, increase data quality, facilitate data sharing across studies, reduce study start-up time, more effectively aggregate information into metadata results, and educate new clinical investigators...
May 2, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29717626/the-moderating-effect-of-ankk1-on-the-association-of-family-environment-with-longitudinal-executive-function-following-traumatic-brain-injury-in-early-childhood-a-preliminary-study
#6
Julia Smith-Paine, Shari L Wade, Amery Treble-Barna, Nanhua Zhang, Huaiyu Zang, Lisa J Martin, Keith Owen Yeates, H Gerry Taylor, Brad G Kurowski
This study examined whether the ankyrin repeat and kinase domain containing 1 gene (ANKK1) C/T single-nucleotide polymorphism (SNP) rs1800497 moderated the association of family environment with long-term executive function (EF) following traumatic injury in early childhood. Caregivers of children with traumatic brain injury (TBI) and children with orthopedic injury (OI) completed the Behavior Rating Inventory of Executive Function (BRIEF) at post injury visits. DNA was collected to identify the rs1800497 genotype in the ANKK1 gene...
May 2, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29705573/the-long-term-outcomes-of-sport-related-concussion-in-pediatric-populations
#7
R Davis Moore, Jacob J Kay, Dave Ellemberg
Although the field of concussion research is rapidly growing, the majority of research has focused on injured adults, with children being an often-neglected population (Kirkwood et al., 2006). Traumatic brain injury is a leading cause of death and disability in children (Langlois et al., 2003), with over 1.5 million cases being treated in North America annually (Yeates et al., 1999). Approximately 75% of these injuries are classified as a concussion (Faul et al., 2010). Further, children are disproportionately affected by sports-related injuries, with 65% of all pediatric concussions occurring during sport and recreation (CDC, 2007)...
April 26, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29703091/exploring-the-relationship-between-examiners-memories-for-performances-domain-separation-and-score-variability
#8
Natasha Cleaton, Peter Yeates, Gareth McCray
BACKGROUND: OSCE examiners' scores are variable and may discriminate domains of performance poorly. Examiners must hold their observations of OSCE performances in "episodic memory" until performances end. We investigated whether examiners vary in their recollection of performances; and whether this relates to their score variability or ability to separate disparate performance domains. METHODS: Secondary analysis was performed on data where examiners had: 1/scored videos of OSCE performances showing disparate student ability in different domains; and 2/performed a measure of recollection for an OSCE performance...
April 27, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29689912/immature-stages-of-the-australian-flower-loving-fly-apiocera-striativentris-diptera-apioceridae
#9
David J Ferguson, David K Yeates
The Apioceridae (Diptera) are relatively large asiloid flies with just over 140 described species worldwide. They are closely related to both Mydidae and Asilidae, and most species are found in Australia and North America, however a handful are found in both southern Africa and southern South America. The immature stages of only one species is known, the Australian beach dune inhabiting species Apiocera maritima Hardy. Like most asiloid larvae, apiocerid larvae are assumed to be predators of other soft-bodied invertebrates in the soil...
February 26, 2018: Zootaxa
https://www.readbyqxmd.com/read/29674358/unmet-rehabilitation-needs-after-hospitalization-for-traumatic-brain-injury
#10
Molly M Fuentes, Jin Wang, Juliet Haarbauer-Krupa, Keith Owen Yeates, Dennis Durbin, Mark R Zonfrillo, Kenneth M Jaffe, Nancy Temkin, David Tulsky, Hilary Bertisch, Frederick P Rivara
OBJECTIVES: In this study, we describe unmet service needs of children hospitalized for traumatic brain injury (TBI) during the first 2 years after injury and examine associations between child, family, and injury-related characteristics and unmet needs in 6 domains (physical therapy, occupational therapy, speech therapy, mental health services, educational services, and physiatry). METHODS: Prospective cohort study of children age 8 to 18 years old admitted to 6 hospitals with complicated mild or moderate to severe TBI...
April 19, 2018: Pediatrics
https://www.readbyqxmd.com/read/29667761/plant-glycosylphosphatidylinositol-gpi-anchored-proteins-at-the-plasma-membrane-cell-wall-nexus
#11
REVIEW
Trevor H Yeats, Antony Bacic, Kim L Johnson
Approximately 1% of plant proteins are predicted to be post-translationally modified with a glycosylphosphatidylinositol (GPI) anchor that tethers the polypeptide to the outer leaflet of the plasma membrane. While the synthesis and structure of GPI anchors is largely conserved across eukaryotes, the repertoire of functional domains present in the GPI-anchored proteome has diverged substantially. In plants, this includes a large fraction of the GPI-anchored proteome being further modified with plant-specific arabinogalactan (AG) O-glycans...
April 18, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29652902/relations-between-right-ventricular-morphology-and-clinical-electrical-and-genetic-parameters-in-brugada-syndrome
#12
Belinda Gray, Ganesh Kumar Gnanappa, Richard D Bagnall, Giuseppe Femia, Laura Yeates, Jodie Ingles, Charlotte Burns, Rajesh Puranik, Stuart M Grieve, Christopher Semsarian, Raymond W Sy
BACKGROUND: Increasing evidence suggests the presence of structural changes affecting the right ventricular outflow tract (RVOT) in patients with Brugada Syndrome (BrS). The aim of this study was to characterise the RV morphology in BrS and explore associations between morphologic, clinical, electrical, and genetic parameters using non-invasive multimodality testing. METHODS: Consecutive BrS patients (recruited 2013-2015) underwent clinical assessment, dedicated RV imaging using cardiac magnetic resonance (CMR) imaging (unless contra-indicated), electrical assessment (electrocardiogram, Holter monitoring, signal-averaged ECG[SAECG]) and genotyping...
2018: PloS One
https://www.readbyqxmd.com/read/29621934/processing-speed-in-children-treated-for-brain-tumors-effects-of-radiation-therapy-and-age
#13
Lisa A Jacobson, E Mark Mahone, Keith O Yeates, M Douglas Ris
The current study examined processing speed in children two years post-treatment for brain tumors (BT) with radiation therapy (RT) compared to those treated with without RT. Participants included 59 children (4-17 years) with BT assessed as part of the Brain Radiation Investigative Study Consortium (BRISC). Processing speed was assessed at two time points: Time1 (3-9 months post-surgery) for 26 children who received whole brain or focal RT (RT group) and 33 treated without RT (no-RT group), and again two years later (Time2) for 42 participants (17 RT, 25 no-RT)...
April 6, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/29621140/naturalness-and-animal-welfare
#14
James Yeates
Naturalness is considered important for animals, and is one criterion for assessing how we care for them. However, it is a vague and ambiguous term, which needs definition and assessments suitable for scientific and ethical questions. This paper makes a start on that aim. This paper differentiates the term from other related concepts, such as species-typical behaviour and wellbeing. It identifies contingent ways in which naturalness might be used, as: (i) prompts for further welfare assessment; (ii) a plausible hypothesis for what safeguards wellbeing; (iii) a threshold for what is acceptable; (iv) constraints on what improvements are unacceptable; and (v) demarcating what is not morally wrong, because of a lack of human agency...
April 5, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29619648/on-the-relation-between-theory-of-mind-and-executive-functioning-a-developmental-cognitive-neuroscience-perspective
#15
Mark Wade, Heather Prime, Jennifer M Jenkins, Keith O Yeates, Tricia Williams, Kang Lee
Theory of mind (ToM) and executive functioning (EF) show marked interrelatedness across childhood, and developmental psychologists have long been interested in understanding the nature of this association. The present review addresses this issue from a cognitive neuroscience perspective by exploring three hypotheses regarding their functional overlap: (1) ToM relies on EF (EF→ToM); (2) EF relies on ToM (ToM→EF); and (3) ToM and EF are mutually related, owing to shared neural structures or networks (ToM↔EF)...
April 4, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29617953/interpersonal-stressors-and-resources-as-predictors-of-adolescent-adjustment-following-traumatic-brain-injury
#16
Ann Lantagne, Robin L Peterson, Michael W Kirkwood, H Gerry Taylor, Terry Stancin, Keith Owen Yeates, Shari L Wade
Objective: The present study sought to examine adolescents' perceptions of their interpersonal stressors and resources across parent, sibling, friend, and school relationships, and the longitudinal associations with self-reported adjustment after traumatic brain injury (TBI) over a 12-month period. Methods: We examined the main effects of stressors and resources on internalizing and externalizing symptoms in 152 adolescents who had sustained complicated mild-to-severe TBI...
March 29, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29615024/re-tamd-exploring-interactions-between-h3-peptide-and-yeats-domain-using-enhanced-sampling
#17
Gilles Lamothe, Thérèse E Malliavin
BACKGROUND: Analysis of preferred binding regions of a ligand on a protein is important for detecting cryptic binding pockets and improving the ligand selectivity. RESULT: The enhanced sampling approach TAMD has been adapted to allow a ligand to unbind from its native binding site and explore the protein surface. This so-called re-TAMD procedure was then used to explore the interaction between the N terminal peptide of histone H3 and the YEATS domain. Depending on the length of the peptide, several regions of the protein surface were explored...
April 3, 2018: BMC Structural Biology
https://www.readbyqxmd.com/read/29601344/effects-of-web-based-parent-training-on-caregiver-functioning-following-pediatric-traumatic-brain-injury-a-randomized-control-trial
#18
Stacey P Raj, Emily L Shultz, Huaiyu Zang, Nanhua Zhang, Michael W Kirkwood, H Gerry Taylor, Terry Stancin, Keith Owen Yeates, Shari L Wade
OBJECTIVE: To examine the effects of a Web-based parenting intervention (I-InTERACT), and an abbreviated version (Express), on caregiver depression, psychological distress, parenting stress, and parenting efficacy following pediatric traumatic brain injury (TBI). SETTING: Four children's hospitals and 1 general hospital in the United States. PARTICIPANTS: 148 caregivers of 113 children aged 3 to 9 years with a moderate to severe TBI. DESIGN: Multicenter randomized controlled trial...
March 29, 2018: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29596650/micronutrients-iodine-status-and-concentrations-of-thyroid-hormones-a-systematic-review
#19
S Maria O'Kane, Maria S Mulhern, L Kirsty Pourshahidi, J J Strain, Alison J Yeates
Context: The metabolism of thyroid hormones, which are essential for normal development, involves many proteins and enzymes. It requires iodine as a key component but is also influenced by several other micronutrients, including selenium, zinc, iron, and vitamin A. Objective: This systematic review was designed to investigate the effect of micronutrient status and supplementation on iodine status and thyroid hormone concentrations. Data Sources: Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines, electronic databases were searched from their inception to April 2016...
March 27, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29573653/maternal-polymorphisms-in-glutathione-related-genes-are-associated-with-maternal-mercury-concentrations-and-early-child-neurodevelopment-in-a-population-with-a-fish-rich-diet
#20
Karin Wahlberg, Tanzy M Love, Daniela Pineda, Karin Engström, Gene E Watson, Sally W Thurston, Alison J Yeates, Maria S Mulhern, Emeir M McSorley, J J Strain, Tristram H Smith, Philip W Davidson, Conrad F Shamlaye, G J Myers, Matthew D Rand, Edwin van Wijngaarden, Karin Broberg
INTRODUCTION: Glutathione (GSH) pathways play a key role the metabolism and elimination of the neurotoxicant methylmercury (MeHg). We hypothesized that maternal genetic variation linked to GSH pathways could influence MeHg concentrations in pregnant mothers and children and thereby also affect early life development. METHODS: The GCLM (rs41303970, C/T), GCLC (rs761142, T/G) and GSTP1 (rs1695, A/G) polymorphisms were genotyped in 1449 mothers in a prospective study of the Seychellois population with a diet rich in fish...
March 21, 2018: Environment International
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