Felix Fischbach, Johanna Richter, Lena Kristina Pfeffer, Boris Fehse, Susanna Carolina Berger, Stefanie Reinhardt, Jens Kuhle, Anita Badbaran, Kristin Rathje, Nico Gagelmann, Dominic Borie, Johan Seibel, Francis Ayuk, Manuel A Friese, Christoph Heesen, Nicolaus Kröger
BACKGROUND: Progressive multiple sclerosis (MS) is characterized by compartmentalized smoldering neuroinflammation caused by the proliferation of immune cells residing in the central nervous system (CNS), including B cells. Although inflammatory activity can be prevented by immunomodulatory therapies during early disease, such therapies typically fail to halt disease progression. CD19 chimeric antigen receptor (CAR)-T cell therapies have revolutionized the field of hematologic malignancies...
March 22, 2024: Med