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https://www.readbyqxmd.com/read/29036223/evaluation-of-blood-brain-barrier-function-by-quotient-alpha2-macroglobulin-and-its-relationship-with-interleukin-6-and-complement-component-3-levels-in-neuropsychiatric-systemic-lupus-erythematosus
#1
Tomoyuki Asano, Hiromi Ito, Yoshinobu Kariya, Kyoka Hoshi, Akioh Yoshihara, Yoshikazu Ugawa, Hideharu Sekine, Shunsei Hirohata, Yoshiki Yamaguchi, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Hiromasa Ohira, Yasuhiro Hashimoto, Hiroshi Watanabe
Although quotient of alpha2 macroglobulin (Qα2MG) was previously reported to be useful for the evaluation of blood-brain barrier (BBB) function, it is not commonly used. We therefore evaluated BBB function among the various subsets of neuropsychiatric systemic lupus erythematosus (NPSLE) using quotient Q α2MG. Furthermore, we determined the correlation between Q α2MG and cerebrospinal (CSF) interleukin (IL)-6 level and quotient complement component 3 (Q C3). To determine intrathecal production of C3, the C3 index (Q C3/Q α2MG) was also calculated...
2017: PloS One
https://www.readbyqxmd.com/read/29032927/mortality-from-systemic-lupus-erythematosus-in-brazil-evaluation-of-causes-according-to-the-government-health-database
#2
Luisa Ribeiro Costi, Hatsumi Miyashiro Iwamoto, Dilma Costa de Oliveira Neves, Cezar Augusto Muniz Caldas
OBJECTIVE: To characterize the causes of mortality in patients with systemic lupus erythematosus (SLE) in Brazil between 2002 and 2011. METHODS: An exploratory ecological study of a time series using data from the Mortality Information System of DATASUS, the Department of the Unified Health System (Brazil's National Health System). RESULTS: Brazil's SLE mortality rate was 4.76 deaths/10(5) inhabitants. The mortality rate was higher in the Midwest, North and Southeast regions than in the country as a whole...
October 9, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29032100/-severity-of-illness-index-in-autoimmune-diseases-have-there-any-usefulness-in-medical-practice
#3
A Saunier, M-A Vandenhende, P Morlat, F Bonnet
INTRODUCTION: Assessing disease activity in patients suffering from autoimmune diseases is complex. Symptoms are multiple, often subjective and there are no reliable biomarkers. Many activity scores have been implemented to compare treatment efficacy in clinical trials. Their use in clinical practice is largely unknown. We performed a practical survey to analyze the use of activity scores in clinical practice to consider treatment response and to assess the determinants of their use. METHODS: A sample of French internists answered a questionnaire about activity scores of systemic lupus erythematosus, Sjögren's syndrome, autoimmune myositis and necrotizing vasculitis of small vessels...
October 11, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29029334/effect-of-long-term-hydroxychloroquine-on-vascular-events-in-patients-with-systemic-lupus-erythematosus-a-database-prospective-cohort-study
#4
Chung-Yuan Hsu, Yu-Sheng Lin, Yu-Jih Su, Hsing-Fen Lin, Ming-Shyan Lin, Ya-Jhu Syu, Tien-Tsai Cheng, Shan-Fu Yu, Jia-Feng Chen, Tien-Hsing Chen
Objectives: The incidence of thromboembolism in patients with SLE is higher than that in the general population. HCQ, widely used to treat lupus, may have vascular protective effects. The aim of this study was to determine whether long-term HCQ exposure is associated with decreased thromboembolism risk in SLE. Methods: We designed a prospective cohort study within an SLE population based on the National Health Insurance Research Database in Taiwan. We divided participants into HCQ and control groups according to HCQ prescription during the first year...
September 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/29027258/acquired-factor-xi-deficiency-and-therapeutic-plasma-exchange
#5
Geoffrey D Wool, Angela Treml, Jonathan L Miller
Congenital factor XI (FXI) deficiency is associated with a variable bleeding phenotype. Recent reports have documented the use of therapeutic plasma exchange to rapidly and isovolumetrically increase FXI levels before invasive procedures in patients with congenital FXI deficiency. We report a case of acquired FXI deficiency in a pregnant woman with lupus. We proved that the inhibitor was an IgG, therefore potentially capable of crossing the placenta. While immune suppression eliminated detectable circulating inhibitor, the woman's FXI remained quite low...
October 13, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29025354/cell-bound-complement-activation-products-as-lupus-biomarkers-diagnosis-monitoring-and-stratification
#6
Joseph M Ahearn, Chau-Ching Liu, Susan Manzi
Cell-bound complement activation products (CB-CAPs) were first reported in 2004, since which time multiple laboratories have demonstrated their value as biomarkers for diagnosis, monitoring, and stratification of patients with systemic lupus erythematosus. Areas Covered: This review summarizes the highlights of these 14 years of CB-CAPs discovery and validation, concluding with a view toward their future potential for precision medicine. Expert Commentary: The practice of medicine is both art and science and each physician can be considered both artist and scientist with a variable blend of the two skill sets...
October 13, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29020082/expression-patterns-of-signaling-lymphocytic-activation-molecule-family-members-in-peripheral-blood-mononuclear-cell-subsets-in-patients-with-systemic-lupus-erythematosus
#7
Maria P Karampetsou, Denis Comte, Katalin Kis-Toth, Vasileios C Kyttaris, George C Tsokos
Genome-wide linkage analysis studies (GWAS) studies in systemic lupus erythematosus (SLE) identified the 1q23 region on human chromosome 1, containing the Signaling Lymphocytic Activation Molecule Family (SLAMF) cluster of genes, as a lupus susceptibility locus. The SLAMF molecules (SLAMF1-7) are immunoregulatory receptors expressed predominantly on hematopoietic cells. Activation of cells of the adaptive immune system is aberrant in SLE and dysregulated expression of certain SLAMF molecules has been reported...
2017: PloS One
https://www.readbyqxmd.com/read/29018537/safety-pharmacokinetics-and-pharmacodynamics-of-amg-811-an-anti-interferon-%C3%AE-monoclonal-antibody-in-sle-subjects-without-or-with-lupus-nephritis
#8
Michael J Boedigheimer, David A Martin, Zahir Amoura, Jorge Sánchez-Guerrero, Juanita Romero-Diaz, Alan Kivitz, Cynthia Aranow, Tak Mao Chan, Yip Boon Chong, Kit Chiu, Christine Wang, Winnie Sohn, Gregory E Arnold, Michael A Damore, Andrew A Welcher, Barbara A Sullivan, Brian L Kotzin, James B Chung
OBJECTIVE: To evaluate safety, pharmacokinetics and pharmacodynamics of anti-interferon (IFN)-γ monoclonal antibody AMG 811 in subjects with SLE without or with lupus nephritis (LN). METHODS: In this phase Ib, randomised, multiple-dose escalation study (NCT00818948), subjects without LN were randomised to subcutaneous AMG 811 (6, 20 or 60 mg) or placebo and subjects with LN were randomised to subcutaneous AMG 811 (20, 60 or 120 mg) or placebo every four weeks for three total doses...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/28993663/renal-iron-accumulation-occurs-in-lupus-nephritis-and-iron-chelation-delays-the-onset-of-albuminuria
#9
Eileen S Marks, Mathilde L Bonnemaison, Susan K Brusnahan, Wenting Zhang, Wei Fan, Jered C Garrison, Erika I Boesen
Proteins involved in iron homeostasis have been identified as biomarkers for lupus nephritis, a serious complication of systemic lupus erythematosus (SLE). We tested the hypothesis that renal iron accumulation occurs and contributes to renal injury in SLE. Renal non-heme iron levels were increased in the (New Zealand Black x New Zealand White) F1 (NZB/W) mouse model of lupus nephritis compared with healthy New Zealand White (NZW) mice in an age- and strain-dependent manner. Biodistribution studies revealed increased transferrin-bound iron accumulation in the kidneys of albuminuric NZB/W mice, but no difference in the accumulation of non-transferrin bound iron or ferritin...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28988316/interspecies-transmission-of-emotional-information-via-chemosignals-from-humans-to-dogs-canis-lupus-familiaris
#10
Biagio D'Aniello, Gün Refik Semin, Alessandra Alterisio, Massimo Aria, Anna Scandurra
We report a study examining interspecies emotion transfer via body odors (chemosignals). Do human body odors (chemosignals) produced under emotional conditions of happiness and fear provide information that is detectable by pet dogs (Labrador and Golden retrievers)? The odor samples were collected from the axilla of male donors not involved in the main experiment. The experimental setup involved the co-presence of the dog's owner, a stranger and the odor dispenser in a space where the dogs could move freely...
October 7, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28988206/cigarette-smoking-and-the-risk-of-systemic-lupus-erythematosus-overall-and-by-anti-double-stranded-dna-antibody-subtype-in-the-nurses-health-study-cohorts
#11
Medha Barbhaiya, Sara K Tedeschi, Bing Lu, Susan Malspeis, David Kreps, Jeffrey A Sparks, Elizabeth W Karlson, Karen H Costenbader
OBJECTIVES: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, subtyped according to clinical manifestations and autoantibodies. Evidence concerning cigarette smoking and SLE risk has been conflicting. We investigated smoking and SLE risk, overall and by anti-double stranded DNA (dsDNA) presence, in two prospective cohort studies. METHODS: The Nurses' Health Study (NHS) enrolled 121 701 US female nurses in 1976; Nurses' Health Study II (NHSII) enrolled 116 430 in 1989...
October 7, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28985591/antiphospholipid-syndrome-and-recurrent-miscarriage-a-systematic-review-and-meta-analysis
#12
REVIEW
Thaís da Silva Santos, Andressa Lorena Ieque, Hayalla Corrêa de Carvalho, Ana Maria Sell, Maria Valdrinez Campana Lonardoni, Izabel Galhardo Demarchi, Quirino Alves de Lima Neto, Jorge Juarez Vieira Teixeira
Antiphospholipid syndrome (APS) is an autoimmune condition that is associated with thrombosis and morbidity in pregnancy. The exact mechanisms by which these associations occur appear to be heterogeneous and are not yet well understood. The aim of this study was to identify and analyze publications in recent years to better understand the diagnosis and its contribution to monitoring APS among women with recurrent miscarriage (RM). This systematic review and meta-analysis was conducted using the PubMed and Web of Knowledge databases, with articles published between 2010 and 2014, according to the PRISMA statement...
September 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28984075/association-of-glucocorticoid-receptor-gene-polymorphisms-with-systemic-lupus-erythematosus-in-a-chinese-population
#13
Yang-Fan Chen, Jian-Hua Xu, Yan-Feng Zou, Li Lian, Fen Wang, Shan-Yu Chen, Jing Cai, Mu Li
OBJECTIVES: To identify the association of glucocorticoid receptor (GR) gene polymorphism with systemic lupus erythematosus (SLE). METHODS: A case-control study was carried out, in which 400 Chinese patients with SLE and 400 normal people were enrolled. DNA was extracted using a genomic DNA extraction kit, and tagged single nucleotide polymorphisms (SNPs) were identified by Haploview (4.0) Project from the Chinese HapMap Project. Eighteen tagged SNPs of the GR gene were genotyped by the Multiplex SNaPshot technique...
October 6, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28975431/comparison-of-plasma-serum-levels-of-procalcitonin-between-infection-and-febrile-disease-flare-in-patients-with-systemic-lupus-erythematosus-a-meta-analysis
#14
Li-Na Liu, Peng Wang, Shi-Yang Guan, Xiao-Mei Li, Bao-Zhu Li, Rui-Xue Leng, Hai-Feng Pan
Currently published data regarding the potential role of procalcitonin (PCT) for the discrimination between systemic lupus erythematosus (SLE) flare and infection are contradictory. To derive a more precise evaluation, a meta-analysis was performed. Published literatures from PubMed, Embase, and the Cochrane Library were obtained. The Newcastle-Ottawa Scale was used to assess the study quality. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by random-effect model analysis...
October 3, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28973834/the-relationship-between-poverty-and-mortality-in-systemic-lupus-erythematosus
#15
Edward Yelin, Jinoos Yazdany, Laura Trupin
OBJECTIVES: A prior study established that concurrent poverty, persistent poverty, and exiting poverty were associated with the subsequent extent of damage accumulation in systemic lupus erythematosus (SLE). The present study examines whether concurrent poverty affects mortality after taking extent of damage accumulation into account. METHODS: Analyses were conducted on 807 persons with SLE participating in the UCSF Lupus Outcomes Study in 2009, stratified by whether they were in households ≤125% of the Federal Poverty Level in that year...
October 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28970217/lupus-low-disease-activity-state-is-associated-with-a-decrease-in-damage-progression-in-caucasian-patients-with-sle-but-overlaps-with-remission
#16
Margherita Zen, Luca Iaccarino, Mariele Gatto, Francesca Saccon, Maddalena Larosa, Anna Ghirardello, Leonardo Punzi, Andrea Doria
OBJECTIVE: To evaluate the prevalence, duration and effect on damage accrual of the 'Lupus Low Disease Activity State' (LLDAS) in a monocentric cohort of patients with systemic lupus erythematosus (SLE). METHODS: We studied 293 Caucasian patients with SLE during a 7-year follow-up period. Disease activity was assessed by SLE Disease Activity Index 2000 (SLEDAI-2K) and SELENA-SLEDAI physician global assessment (PGA), and damage by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)...
September 26, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28967499/multiple-primary-squamous-cell-carcinomas-of-the-lower-lip-and-tongue-arising-in-discoid-lupus-erythematosus-a-case-report
#17
Ioanna-Eirini Arvanitidou, Nikolaos G Nikitakis, Maria Georgaki, Nick Papadogeorgakis, Athanasios Tzioufas, Alexandra Sklavounou
Squamous cell carcinoma (SCC) developing in lesions of discoid lupus erythematosus (DLE) is rare, most frequently arising on sun-exposed skin and very rarely affecting the lips. A review of the English language literature revealed only 21 published cases of labial SCC in patients with DLE. Here, an unusual case of a patient with DLE who developed 3 primary SCCs of the oral and perioral region is presented. A 40-year-old female with a 24-year history of DLE with peri- and intraoral involvement initially developed SCC of the vermillion border of the right lower lip; the lesion was surgically removed and did not recur within 6 months...
August 30, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28963441/pathological-significance-and-regulatory-mechanism-of-lymphotoxin-%C3%AE-receptor-overexpression-in-t-cells-of-patients-with-systemic-lupus-erythematosus
#18
Cheng Yin, Xu-Bing Cai, Hui-Juan Wang, Bing-Jie Gu, Xiao-Fan Yang, Rong Zhang, Xiao-Hui Ji
Systemic lupus erythematosus (SLE) is a typical autoimmune disease. Lymphotoxin β receptor (LTβR) signaling plays an important role in autoimmune inflammations. LTβR-Ig fusion protein, LTβR blocking agent, has been used to treat SLE, while its mechanism remains to be fully elucidated. In this study, to investigate the expression of LTβR in the T cells of SLE patients and its roles in the pathogenesis of SLE, we isolated the peripheral blood T cells of SLE patients and normal controls to detect expression of LTβR by flow cytometry and RNA assay...
September 30, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28955334/the-role-of-brain-reactive-autoantibodies-in-brain-pathology-and-cognitive-impairment
#19
REVIEW
Simone Mader, Lior Brimberg, Betty Diamond
Antibodies to different brain proteins have been recently found to be associated with an increasing number of different autoimmune diseases. They need to penetrate the blood-brain barrier (BBB) in order to bind antigens within the central nervous system (CNS). They can target either neuronal or non-neuronal antigen and result in damage either by themselves or in synergy with other inflammatory mediators. Antibodies can lead to acute brain pathology, which may be reversible; alternatively, they may trigger irreversible damage that persists even though the antibodies are no longer present...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28953716/five-year-safety-data-for-more-than-55-000-subjects-following-breast-implantation-comparison-of-rare-adverse-event-rates-with-silicone-implants-versus-national-norms-and-saline-implants
#20
MULTICENTER STUDY
Navin Singh, George J Picha, Bhushan Hardas, Andrew Schumacher, Diane K Murphy
BACKGROUND: The U.S. Food and Drug Administration has required postapproval studies of silicone breast implants to evaluate the incidence of rare adverse events over 10 years after implantation. METHODS: The Breast Implant Follow-Up Study is a large 10-year study (>1000 U.S. sites) evaluating long-term safety following primary augmentation, revision-augmentation, primary reconstruction, or revision-reconstruction with Natrelle round silicone breast implants compared with national norms and outcomes with saline implants...
October 2017: Plastic and Reconstructive Surgery
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