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https://www.readbyqxmd.com/read/29221480/prevalence-and-etiologies-of-pulmonary-hypertension-in-africa-a-systematic-review-and-meta-analysis
#1
Jean Joel Bigna, Jean Jacques Noubiap, Jobert Richie Nansseu, Leopold Ndemnge Aminde
BACKGROUND: Despite the recent increasing worldwide attention towards pulmonary hypertension (PH), its epidemiology remains poorly described in Africa. Accordingly, we performed a systematic review and meta-analysis of PH prevalence, incidence and etiologies in Africa. METHODS: We searched PubMed, EMBASE, African Journals Online, and Africa Index Medicus. Published observational studies until September 20, 2017, including adult participants residing in Africa were considered...
December 8, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29217175/reactivity-of-igm-antibodies-elicited-by-pegylated-liposomes-or-pegylated-lipoplexes-against-auto-and-foreign-antigens
#2
Hidenori Ando, Amr S Abu Lila, Munehira Kawanishi, Taro Shimizu, Keiichiro Okuhira, Yu Ishima, Tatsuhiro Ishida
Polyethylene glycol (PEG) is an attractive tool for the development of nanoparticle-based cancer therapy since it endows nanoparticles with extended-circulation properties. Nevertheless, recent reports have revealed that intravenous injection of either PEGylated liposomes (SLs) or PEGylated lipoplex (PLpx) could elicit an anti-PEG immunoglobulin (IgM) response in a T cell-independent (TI) manner that would substantially compromise the in vivo fate of PEGylated products upon repeated administration. In the same context, viral or bacterial infections trigger the production of polyreactive IgM that binds both self and foreign antigens...
December 4, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29216396/short-term-efficacy-and-safety-of-rituximab-therapy-in-refractory-systemic-lupus-erythematosus-results-from-the-british-isles-lupus-assessment-group-biologics-register
#3
Eoghan M McCarthy, Emily Sutton, Stephanie Nesbit, James White, Ben Parker, David Jayne, Bridget Griffiths, David A Isenberg, Anisur Rahman, Caroline Gordon, David P D'Cruz, Benjamin Rhodes, Peter Lanyon, Edward M Vital, Chee-Seng Yee, Christopher J Edwards, Lee-Suan Teh, Mohammed Akil, Neil J McHugh, Asad Zoma, Ian N Bruce
Objectives: To describe the baseline characteristics of SLE patients requiring biologic therapy in the UK and to explore short term efficacy and infection rates associated with rituximab (RTX) use. Methods: Patients commencing biologic therapy for refractory SLE and who consented to join BILAG-BR were analysed. Baseline characteristics, disease activity (BILAG 2004/SLEDAI-2K) and rates of infection over follow-up were analysed. Response was defined as loss of all A and B BILAG scores to ⩽ 1 B score with no new A/B scores in other organ systems at 6 months...
December 5, 2017: Rheumatology
https://www.readbyqxmd.com/read/29214394/serious-adverse-events-associated-with-anti-tumor-necrosis-factor-alpha-agents-in-pediatric-onset-inflammatory-bowel-disease-and-juvenile-idiopathic-arthritis-in-a-real-life-setting
#4
Serena Pastore, Samuele Naviglio, Arianna Canuto, Loredana Lepore, Stefano Martelossi, Alessandro Ventura, Andrea Taddio
OBJECTIVES: Anti-tumor necrosis factor alpha (anti-TNF-α) agents are generally well tolerated, yet they can be associated with serious adverse events (SAEs) in a minority of patients. We examined the incidence of SAEs in a pediatric referral center for chronic rheumatologic and gastroenterological inflammatory disorders. METHODS: Retrospective analysis of SAEs occurring during treatment with anti-TNF-α agents in patients with juvenile idiopathic arthritis (JIA) (n = 78)  or pediatric-onset inflammatory bowel disease (IBD) (n = 105) seen at the Institute for Maternal and Child Health IRCCS "Burlo Garofolo" in Trieste, Italy, between June 2001 and February 2016...
December 6, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/29212518/effect-of-low-and-high-hdl-c-levels-on-the-prognosis-of-lupus-nephritis-patients-a-prospective-cohort-study
#5
Peiran Yin, Ying Zhou, Bin Li, Lingyao Hong, Wei Chen, Xueqing Yu
BACKGROUND: Few data has been available on the effect of serum HDL-C levels on the prognosis of lupus nephritis (LN) patients. The present study therefore aimed to explore the effect of serum HDL-C levels on LN patients. METHODS: We included 775 patients with follow-up information registered in an LN database between 1 January 2006 and 31 December 2011. The patients were divided into groups with low, intermediate and high HDL-C, according to NCEP ATPIII criteria...
December 6, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29210959/acute-frosted-retinal-periphlebitis-in-a-patient-with-mediterranean-fever
#6
Köse Özlem, Willermain François, Caspers Laure, Postelmans Laurence, El Ouardighi Hind, Guillaume Marie-Paule, Makhoul Dorine
PURPOSE: To present a case of frosted branch periphlebitis in a young Armenian patient with familial Mediterranean fever. METHODS: Case report. RESULTS: A 37-year-old man presented with a unilateral decreased visual acuity and floaters for 4 days on the left eye (LE). Visual acuity was 20/20 in the right eye (RE) and 20/28 in the LE. Anterior segment and fundus examinations of the RE were normal. Slit-lamp examination of LE revealed a mild nongranulomatous anterior uveitis and vitritis...
November 23, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29210313/pain-predicts-poorer-health-related-quality-of-life-in-childhood-onset-systemic-lupus-erythematosus-a-cohort-study
#7
Ji Li, Jordan T Jones, Catherine Donnelly, Natoshia Cunningham, Susmita Kashikar-Zuck, Hermine I Brunner
Objectives To investigate the predictive value of pain on health-related quality of life (HRQoL) among patients with childhood-onset systemic lupus erythematous (cSLE), as increased adverse psychosocial events are reported in patients with cSLE, but the predictive impact of psychological events on HRQoL remains unclear. Methods This cohort study recruited patients with cSLE from the Cincinnati Children's Hospital Medical Centre rheumatology clinic. Data regarding pain due to lupus in past week, and HRQoL, were collected during a baseline and 6-month follow-up visit...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29208022/role-of-endoplasmic-reticulum-stress-in-the-protective-effects-of-ppar%C3%AE-%C3%AE-activation-on-endothelial-dysfunction-induced-by-plasma-from-patients%C3%A2-with-lupus
#8
Marta Toral, Rosario Jiménez, Miguel Romero, Iñaki Robles-Vera, Manuel Sánchez, Mercedes Salaices, José Mario Sabio, Juan Duarte
BACKGROUND: We tested whether GW0742, a peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) agonist, improves endothelial dysfunction induced by plasma from patients with systemic lupus erythematosus (SLE) involving the inhibition of endoplasmic reticulum (ER) stress. METHODS: A total of 12 non-pregnant women with lupus and 5 non-pregnant healthy women (controls) participated in the study. Cytokines and double-stranded DNA autoantibodies (anti-dsDNA) were tested in plasma samples...
December 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29207757/vitamin-d-levels-and-associations-in-indian-patients-with-primary-sj%C3%A3-gren-s-syndrome
#9
Pulukool Sandhya, Gowri Mahasampath, Puneet Mashru, Joseph Dian Bondu, Victoria Job, Debashish Danda
Introduction: Vitamin D is a steroid hormone belonging to the class of secosteroids with myriad immune functions and has been implicated in aetiopathogenesis of various autoimmune diseases. Although, there have been various studies showing the association of vitamin D in rheumatoid arthritis and lupus in different populations, there have been limited studies on vitamin D and primary Sjögren's Syndrome (pSS). There are no studies on association of vitamin D and pSS from any tropical country including Indian subcontinent...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205894/association-of-angiotensin-converting-enzyme-insertion-deletion-polymorphism-with-susceptibility-to-systemic-lupus-erythematosus-a-meta-analysis
#10
An-Fang Huang, Hui Li, Lei Ke, Chao Yang, Xiao-Yan Liu, Zu-Cheng Yang, Fen Xu, Hong Jia, Wang-Dong Xu
BACKGROUND: The aim of this study was to determine whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism confers susceptibility to systemic lupus erythematosus (SLE)/lupus nephritis (LN). METHODS: A meta-analysis was conducted on the association between the ACE I/D polymorphism and SLE/LN (when available) using: (i) the allelic contrast; (ii) the recessive; (iii) the dominant; and (iv) the additive models. RESULTS: A total of 27 relevant comparisons meeting the inclusion criteria were identified, involving 2718 SLE patients and 3655 controls...
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29199038/association-of-interleukin-10-gene-single-nucleotide-polymorphisms-with-susceptibility-to-systemic-lupus-erythematosus-in-a-chinese-population
#11
Tian-Tian Lv, Jun Wu, Jun Li, Tian-Ping Zhang, Xiao-Ke Yang, Nan Xiang, Yin-Guang Fan, Hai-Feng Pan, Bin Wang
The aim of this study was to investigate the association of interleukin (IL)-10 gene single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese population. 848 SLE patients and 461 normal controls were recruited in this study. Nine SNPs in IL-10 gene (rs1518110, rs1518111, rs1554286, rs1800890, rs1800893, rs3024493, rs3024495, rs3024498 and rs6667202) were genotyped using TaqMan genotyping assays on Fluidigm 192.24 system. The frequency of IL-10 rs3024498-C allele was significantly higher in patient group compared with control subjects (OR=5...
November 30, 2017: Gene
https://www.readbyqxmd.com/read/29197836/systemic-lupus-erythematosus-sle-an-unusual-cause-of-ileocolic-intussusception
#12
Naomi Glijn, Lindy-Anne Korswagen, Wai-Kwan Lam-Tse
Intussusception is a rare diagnosis in adults. Gastrointestinal involvement is not unusual in systemic lupus erythematosus (SLE).1 A case of intussusception as first presenting symptom of SLE is described. A 50-year-old woman of Chinese origin came to the emergency room with symptoms of high fever, nausea, vomiting and weight loss of 10 kg. Three months before, an episode with abdominal pain due to ileal invagination in the colon occurred. Laboratory analysis showed: thrombocytopaenia, lymphopaenia, positive antinuclear antibody, antidouble-stranded DNA, Coombs tests and low C3 in combination with an active urine sediment and proteinuria...
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29196891/sodium-valproate-modulates-immune-response-by-alternative-activation-of-monocyte-derived-macrophages-in-systemic-lupus-erythematosus
#13
Saeed Mohammadi, Marie Saghaeian-Jazi, Sima Sedighi, Ali Memarian
The anti-inflammatory role of macrophages in apoptotic cells (ACs) clearance is involved in Systemic Lupus Erythematosus (SLE) pathogenesis. The efferocytic capability of macrophages is altered by M1/M2 polarization. Histone deacetylase inhibitors (HDACi) are proposed to enhance the expansion of M2 macrophages. Sodium valproate (VPA) is an HDACi with different anti-inflammatory properties. Here, we aimed to investigate the effects of HDACi by VPA on the polarization of monocyte-derived macrophages (MDMs) and regulating the expression of anti-inflammatory cytokines in SLE...
December 1, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29196292/gut-microbiota-in-human-sle-and-a-mouse-model-of-lupus
#14
Xin M Luo, Michael R Edwards, Qinghui Mu, Yang Yu, Miranda D Vieson, Christopher M Reilly, S Ansar Ahmed, Adegbenga A Bankole
Gut microbiota dysbiosis has been observed in a number of autoimmune diseases. However, the role of gut microbiota in systemic lupus erythematosus (SLE), a prototypical autoimmune disease characterized by persistent inflammation in multiple organs of the body, remains elusive. Here we report the dynamics of gut microbiota in a murine lupus model, NZB/W F1, as well as intestinal dysbiosis in a small group of SLE patients with active disease. The composition of gut microbiota changed markedly before and after the onset of lupus disease in NZB/W F1 mice, with higher diversity and increased representation of several bacterial species as lupus progressed from pre-disease to the diseased stage...
December 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29194681/a-population-based-study-of-perinatal-infection-risk-in-women-with-and-without-systemic-lupus-erythematosus-and-their-infants
#15
Rachel A Bender Ignacio, Amy T Madison, Ata Moshiri, Noel S Weiss, Beth A Mueller
BACKGROUND: Increased risk of adverse birth outcomes is well described in women with systemic lupus erythematosus (SLE), but risk of maternal or infant infection in the peripartum period has not been well studied. We conducted a population-based cohort study of infection risk in women with and without SLE and their infants. METHODS: Linked birth-hospital discharge data identified 1297 deliveries to women with SLE and a 4:1 comparison cohort of deliveries to women without SLE in Washington State, 1987-2013...
December 1, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29193951/-disseminated-tuberculosis-in-a-patient-with-overlap-syndrome-challenges-in-preventing
#16
Sergio García-Méndez, Lamberto Miguel Caballero-Zavala, Imelda García-Olivera, Fortunato Vásquez-Manuel, Gerardo Pérez-Bustamante, Fabián Tafoya-Ramírez
Patients with autoimmune rheumatic diseases are at increased risk for developing infections and these are associated with increased morbidity and mortality from these diseases, especially in patients with systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis and autoimmune inflammatory myopathies. The objective of this paper is to address the challenges in detecting latent tuberculosis in immunosuppressed patients and the initiation of prophylactic treatment because currently there are no well-defined guidelines indicating what action to take for detection and treatment; so far the available scientific evidence is scarce and some methodological shortcomings...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29193893/sex-differences-in-healthcare-utilization-end-stage-renal-disease-and-mortality-among-medicaid-beneficiaries-with-incident-lupus-nephritis
#17
Candace H Feldman, Anna Broder, Hongshu Guan, Jinoos Yazdany, Karen H Costenbader
OBJECTIVE: While systemic lupus erythematosus (SLE) and lupus nephritis (LN) disproportionately affect females, prior studies suggest that males may experience poorer outcomes. We investigated sex differences in healthcare utilization, end-stage renal disease (ESRD) and mortality among patients with LN receiving Medicaid, public insurance for low-income individuals. METHODS: Within Medicaid Analytic eXtract (MAX) from 29 states (2000-2010), we used billing claims to identify individuals 5-65 years with incident LN (PPV 80%)...
November 28, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29193883/economic-evaluation-of-lupus-nephritis-in-the-systemic-lupus-international-collaborating-clinics-inception-cohort-using-a-multistate-model-approach
#18
Megan R W Barber, John G Hanly, Li Su, Murray B Urowitz, Yvan St Pierre, Juanita Romero-Diaz, Caroline Gordon, Sang-Cheol Bae, Sasha Bernatsky, Daniel J Wallace, David A Isenberg, Anisur Rahman, Ellen M Ginzler, Michelle Petri, Ian N Bruce, Paul R Fortin, Dafna D Gladman, Jorge Sanchez-Guerrero, Rosalind Ramsey-Goldman, Munther A Khamashta, Cynthia Aranow, Meggan Mackay, Graciela S Alarcón, Susan Manzi, Ola Nived, Andreas Jönsen, Asad A Zoma, Ronald F van Vollenhoven, Manuel Ramos-Casals, Guillermo Ruiz-Irastorza, S Sam Lim, Kenneth C Kalunian, Murat Inanc, Diane L Kamen, Christine A Peschken, Soren Jacobsen, Anca Askanase, Chris Theriault, Vernon Farewell, Ann E Clarke
OBJECTIVE: Little is known about the long-term costs of lupus nephritis (LN). These were compared between patients with and without LN based on multistate modelling. METHODS: Patients from 32 centres in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis and provided annual data on renal function, hospitalizations, medications, dialysis, and selected procedures. LN was diagnosed by renal biopsy or the American College of Rheumatology classification criteria...
November 28, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29190882/functional-polymorphisms-in-pre-mir146a-and-pre-mir499-are-associated-with-systemic-lupus-erythematosus-but-not-with-rheumatoid-arthritis-or-graves-disease-in-mexican-patients
#19
Isidro Alemán-Ávila, Mayra Jiménez-Morales, Olga Beltrán-Ramírez, Rosa Elda Barbosa-Cobos, Silvia Jiménez-Morales, Fausto Sánchez-Muñoz, Guillermo Valencia-Pacheco, Luis M Amezcua-Guerra, Yaneli Juárez-Vicuña, Dulce Milagro Razo-Blanco Hernández, María Concepción Aguilera-Cartas, Ricardo F López-Villanueva, Oscar Peralta-Zaragoza, Carlos Tovilla-Zárate, Julian Ramírez-Bello
Recently, different microRNA (miRNA) gene polymorphisms have been evaluated in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Graves' disease (GD). In the present study, we examined three single-nucleotide polymorphisms (SNPs) located in the pre-miR-146a (rs2910164G/C), pre-miR-196a-2 (rs11614913C/T), and pre-miR-499 (rs3746444A/G) genes. Our study population included 900 Mexican patients with RA, SLE, or GD, as well as 486 healthy control individuals with no family history of inflammatory or autoimmune diseases...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29186654/treatment-with-allogenic-mesenchymal-stromal-cells-in-a-murine-model-of-systemic-lupus-erythematosus
#20
Chiara Tani, Sabrina Vagnani, Linda Carli, Francesca Querci, Anja A Kühl, Simone Spieckermann, Constanze Pamela Cieluch, Simone Pacini, Rita Fazzi, Marta Mosca
Objective: Pre-clinical and uncontrolled studies in patients with systemic lupus erythematosus (SLE) showed that mesenchymal stromal cells (MSCs) have a potential therapeutic role in refractory cases. The optimal therapeutic strategy in these patients remain to be elucidated. Our aim was to test the hypothesis that repeated administrations of 1×106/kg body weight of allogenic MSCs, that is a significantly lower dosage with respect to the fixed 1×106 MSC used in animal models, can be effective in improving the clinical course of a murine SLE model...
November 30, 2017: International Journal of Stem Cells
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