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https://www.readbyqxmd.com/read/29675623/influence-of-autoimmunity-and-inflammation-on-endothelial-function-and-thrombosis-in-systemic-lupus-erythematosus-patients
#1
Kamil Bugała, Adam Mazurek, Krzysztof Gryga, Monika Komar, Grzegorz Kopeć, Jacek Musiał, Piotr Podolec, Carlo Perricone, Wojciech Płazak
The aim of this study is to assess the relationship between autoimmunity and endothelial activation/damage (ICAM-1 and vWF serum levels) and the degree of prothrombotic activity (thrombin-antithrombin complexes-TAT serum levels) in SLE. In 60 clinically stable SLE patients, levels of the following parameters were estimated in their serum: lupus anticoagulant (LA), anticardiolipin antibodies in both IgG and IgM classes (aCL-IgG and aCL-IgM, respectively), antiβ2GPI antibodies in both IgG and IgM classes (antiβ2GPI-IgG and antiβ2GPI-IgM, respectively), ICAM, von Willebrand factor (vWF), TAT, CRP, C3c, C4, and IL-6...
April 20, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29671953/bone-marrow-as-a-target-organ-of-systemic-lupus-erythematosus-analysis-of-cases-with-myelofibrosis
#2
Döndü Üsküdar Cansu, Hava Üsküdar Teke, Serap Işiksoy, Cengiz Korkmaz
AIM: Cytopenia in the course of systemic lupus erythematosus (SLE) may be due to multiple factors. In this study, we aimed primarily to evaluate the detailed results of bone marrow (BM) biopsies of SLE patients, secondly to determine the myelofibrosis (MF) frequency and thirdly to compare BM morphologic findings as well as the clinical and laboratory parameters between groups (with MF and without MF) in cytopenic SLE patients. METHODS: We retrospectively analyzed 224 SLE patients' files...
April 19, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29671689/two-cases-of-anaphylactic-shock-by-methylprednisolone-in-neuromyelitis-optica
#3
Keita Takahashi, Tetsuya Asano, Yuichi Higashiyama, Shigeru Koyano, Hiroshi Doi, Hideyuki Takeuchi, Fumiaki Tanaka
Steroid pulse therapy with methylprednisolone (mPSL) succinate ester is the most common treatment for neuromyelitis optica (NMO); no cases of anaphylaxis have been reported to date. Here, we report two cases of anaphylactic shock induced by mPSL pulse therapy in patients with NMO and concurrent systemic lupus erythematosus. Both patients had received several courses of mPSL pulse therapy without any problems previously. Repeated mPSL pulse therapy and comorbid humoral autoimmune disease might increase the risk of anaphylaxis...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29670626/prophylactic-and-therapeutic-effects-of-interleukin-2-il-2-anti-il-2-complexes-in-systemic-lupus-erythematosus-like-chronic-graft-versus-host-disease
#4
Stefan Heiler, Jonas Lötscher, Matthias Kreuzaler, Johanna Rolink, Antonius Rolink
Murine chronic graft-versus-host-disease (cGvHD) induced by injection of parental lymphocytes into F1 hybrids results in a disease similar to systemic lupus erythematosus. Here, we have used DBA/2 T cell injection into (C57BL/6 × DBA/2)F1 (BDF1) mice as a model system to test the prophylactic and therapeutic effects of interleukin-2 (IL-2)/anti-IL-2 immune complexes on the course of cGvHD. Our findings demonstrate that pretreatment with Treg inducing JES6/IL-2 complexes render BDF1 mice largely resistant to induction of cGvHD, whereas pretreatment with CD8+ T cell/NK cell inducing S4B6/IL-2 complexes results in a more severe cGvHD...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29669399/the-impact-of-systemic-lupus-erythematosus-on-the-clinical-phenotype-of-antiphospholipid-antibody-positive-patients-results-from-antiphospholipid-syndrome-alliance-for-clinical-trials-and-international-networking-aps-action-clinical-database-and-repository
#5
Ozan Unlu, Doruk Erkan, Medha Barbhaiya, Danieli Andrade, Iana Nascimento, Renata Rosa, Alessandra Banzato, Vittorio Pengo, Amaia Ugarte, Maria Gerosa, Lanlan Ji, Maria Efthymiou, D Ware Branch, Guilherme Raires de Jesus, Angela Tincani, H Michael Belmont, Paul R Fortin, Michelle Petri, Esther Rodriguez, Guillermo J Pons-Estel, Jason S Knight, Tatsuya Atsumi, Rohan Willis, Stephane Zuily, Maria G Tektonidou
OBJECTIVE: Although systemic lupus erythematosus (SLE) is the most common autoimmune disease associated with antiphospholipid antibodies (aPL), limited data exist on the impact of SLE on the clinical phenotype of aPL-positive patients. The primary objective was to compare the clinical, laboratory, and treatment characteristics of aPL-positive patients with or without SLE. METHODS: A secure web-based data capture system stores patient demographics, and aPL-related clinical and laboratory characteristics...
April 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29668590/a-case-report-of-lupus-erythematosus-tumidus-converted-from-discoid-lupus-erythematosus
#6
Xiaomei Chen, Sheng Wang, Li Li
RATIONALE: Lupus erythematosus tumidus (LET) is an uncommon type of cutaneous lupus erythematosus (CLE) that is rarely associated with other forms of lupus erythematosus. PATIENT CONCERNS: We report a 62-year-old Chinese man presented with recurrent erythematous facial plaques for 1 year and a low-grade fever for 1 week. He had been diagnosed as discoid lupus erythematosus (DLE) 1 year before. Physical examination showed diverse lesions, including prominent swelling of the eyelids, a few erythematous, edematous plaques on the left forehead, face, and neck, and 2 hairless macules...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668584/combined-utilization-of-untimed-single-urine-of-mcp-1-and-tweak-as-a-potential-indicator-for-proteinuria-in-lupus-nephritis-a-case-control-study
#7
Xiwen Dong, Zhaohui Zheng, Xing Luo, Jin Ding, Ying Li, Zhiqin Li, Sijia Li, Mengyao Rong, Yalu Fu, Zhenbiao Wu, Ping Zhu
The aim of this study was to determine whether combined utilization of untimed single urine monocyte chemoattractant protein 1 (uMCP-1) and tumor necrosis factor (TNF)-like weak inducer of apoptosis (uTWEAK) could serve as a screening test for proteinuria in patients with lupus nephritis (LN).A case-control study that contained 39 biopsy-proven LN patients, 20 non-LN systemic lupus erythematosus (SLE) patients, and 10 healthy controls (HCs) were carried out. Correlations between uMCP-1, uTWEAK, and traditional clinical markers were analyzed by Spearman correlation test...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667858/longitudinal-analysis-of-varicella-zoster-virus-specific-antibodies-in-systemic-lupus-erythematosus-no-association-with-subclinical-viral-reactivations-or-lupus-disease-activity
#8
C Rondaan, C C van Leer, S van Assen, H Bootsma, K de Leeuw, S Arends, N A Bos, J Westra
Systemic lupus erythematosus (SLE) patients are at high risk of herpes zoster. Previously, we found increased immunoglobulin (Ig)G levels against varicella-zoster virus (VZV) in SLE patients compared to controls, while antibody levels against diphtheria and cellular immunity to VZV were decreased. We aimed to test our hypothesis that increased VZV-IgG levels in SLE result from subclinical VZV reactivations, caused by stress because of lupus disease activity or immunosuppressive drug use. Methods Antibody levels to VZV (IgG, IgA, IgM), total IgG and VZV-DNA were longitudinally determined in the serum of 34 SLE patients, using enzyme-linked immunosorbent assay and polymerase chain reaction...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29667857/determining-risk-factors-that-increase-hospitalizations-in-patients-with-systemic-lupus-erythematosus
#9
D Li, H M Madhoun, W N Roberts, W Jarjour
Introduction Systemic lupus erythematosus (SLE) is a complex disease that is associated with significant mortality and an increased risk of hospitalization. Several validated instruments are available to measure disease activity in SLE patients. However, these instruments were not designed to screen for SLE patients at an increased risk of hospitalization. These instruments also fail to incorporate some data that are easily obtainable from electronic health records, such as the frequency of missed outpatient appointments...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29665758/the-efficacy-of-adjunct-tacrolimus-treatment-in-pregnancy-outcomes-in-patients-with-systemic-lupus-erythematosus
#10
K Ichinose, S Sato, Y Kitajima, Y Horai, K Fujikawa, M Umeda, S Fukui, A Nishino, T Koga, S Y Kawashiri, N Iwamoto, M Tamai, H Nakamura, T Origuchi, I Yasuhi, H Masuzaki, A Kawakami
Systemic lupus erythematosus (SLE) involves multiple organ systems and primarily affects women during their reproductive years. Pregnancy in a woman with SLE may lead to higher rates of disease flares. Little is known regarding which medications are safe to maintain remission and/or treat flares throughout such pregnancies. Here we retrospectively analyzed the efficacy of tacrolimus (TAC) in the pregnancy outcomes of SLE patients. We studied the 54 deliveries of 40 SLE patients over an eight-year period from 2008 to 2016...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29665754/the-clinical-manifestations-and-response-to-treatment-in-south-africans-with-lupus-nephritis
#11
P G Mody, G M Mody, A Assounga
There are varying observations on the influence of ethnicity on the clinical spectrum and response to treatment in lupus nephritis (LN). We studied a multiethnic South African LN cohort to determine the clinical manifestations, histological involvement and response to therapy. We reviewed the records of LN patients at Inkosi Albert Luthuli Central Hospital in Durban. There were 105 patients, 92.5% females and they comprised 49.1% Indians and 45.3% African Blacks. The mean age was 31.3 ± 12.5 years, and 41...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29661905/randomized-study-of-adjunctive-belimumab-in-participants-with-generalized-myasthenia-gravis
#12
Karen Hewett, Donald B Sanders, Richard A Grove, Christine L Broderick, Todd J Rudo, Ashlyn Bassiri, Marina Zvartau-Hind, Vera Bril
OBJECTIVE: To investigate the efficacy and safety of belimumab, a fully human immunoglobulin G1λ monoclonal antibody against B-lymphocyte stimulator, in participants with generalized myasthenia gravis (MG) who remained symptomatic despite standard of care (SoC) therapy. METHODS: Eligible participants with MG were randomized 1:1 to receive IV belimumab 10 mg/kg or placebo in this phase II, placebo-controlled, multicenter, double-blind study (NCT01480596; BEL115123)...
April 17, 2018: Neurology
https://www.readbyqxmd.com/read/29661540/mif-functional-polymorphisms-794-catt-5-8-and-173-g-c-are-associated-with-mif-serum-levels-severity-and-progression-in-male-multiple-sclerosis-from-western-mexican-population
#13
V A Castañeda-Moreno, U De la Cruz-Mosso, N Torres-Carrillo, M A Macías-Islas, O Padilla-De la Torre, M A Mireles-Ramírez, O González-Pérez, J L Ruiz-Sandoval, M Huerta, X Trujillo, D Ortuño-Sahagún, Muñoz-Valle Jf
Macrophage migration inhibitory factor (MIF) is a cytokine associated with tissue damage in multiple autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and psoriatic arthritis. The role of MIF in multiple sclerosis (MS) and the contribution of its polymorphisms are unknown in our population. Therefore, we decided to investigate the genetic association of -794 CATT5-8 (rs5844572) and -173 G>C (rs755622) MIF polymorphisms with MS, clinical variables and MIF serum levels in the population of western Mexico...
April 10, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29660305/temporomandibular-joint-reconstruction-in-patients-with-autoimmune-connective-tissue-disease
#14
Pushkar Mehra, Charles Henry, Mohammed Nadershah
PURPOSE: To evaluate clinical outcomes in patients with autoimmune or connective tissue (CT) disease undergoing temporomandibular joint (TMJ) reconstruction. MATERIALS AND METHODS: Patients were divided into 2 groups based on type of TMJ reconstruction. Patients in group 1 (n = 9) underwent autogenous reconstruction and had a diagnosis of rheumatoid arthritis (5), lupus arthritis (1), and psoriatic arthritis (3). Patients in group 2 (n = 2l) had alloplastic reconstruction with a patient-fitted total joint prosthesis (TMJ Concepts, Ventura, CA) and had a diagnosis of rheumatoid arthritis (15), lupus (3), and psoriatic arthritis (3)...
March 22, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29659615/natural-regeneration-on-seismic-lines-influences-movement-behaviour-of-wolves-and-grizzly-bears
#15
Laura Finnegan, Karine E Pigeon, Jerome Cranston, Mark Hebblewhite, Marco Musiani, Lalenia Neufeld, Fiona Schmiegelow, Julie Duval, Gordon B Stenhouse
Across the boreal forest of Canada, habitat disturbance is the ultimate cause of caribou (Rangifer tarandus caribou) declines. Habitat restoration is a focus of caribou recovery efforts, with a goal to finding ways to reduce predator use of disturbances, and caribou-predator encounters. One of the most pervasive disturbances within caribou ranges in Alberta, Canada are seismic lines cleared for energy exploration. Seismic lines facilitate predator movement, and although vegetation on some seismic lines is regenerating, it remains unknown whether vegetation regrowth is sufficient to alter predator response...
2018: PloS One
https://www.readbyqxmd.com/read/29657153/repeat-testing-of-antibodies-and-complements-in-systemic-lupus-erythematosus-when-is-it-enough
#16
Thomas C Raissi, Carly Hewson, Janet E Pope
OBJECTIVE: Patients with systemic lupus erythematosus (SLE) frequently undergo repeat testing for antibodies against extractable nuclear antigens (anti-ENA), but it is not known whether this is necessary or cost-effective. This study characterized the frequencies of changes in anti-ENA, anti-dsDNA, and complement C3 and C4 upon repeat testing. METHODS: Chart review was done at one site of 130 patients with SLE enrolled in the 1000 Canadian Faces of Lupus prospective registry with annual antibody and complement testing...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29657143/clinical-and-serological-associations-with-the-development-of-incident-proteinuria-in-danish-patients-with-systemic-lupus-erythematosus
#17
Nima Tanha, Renata Baronaite Hansen, Christoffer Tandrup Nielsen, Mikkel Faurschou, Søren Jacobsen
OBJECTIVE: In a longitudinal cohort study, we investigated whether clinical and serological manifestations at the time of classification of systemic lupus erythematosus (SLE) were predictive of subsequent development of incident proteinuria as a biomarker of incident lupus nephritis. METHODS: Patients fulfilling SLE classification criteria but having no proteinuria prior to or at the time of classification were included. Data on SLE manifestations, vital status, criteria-related autoantibodies, and SLE-associated medications were collected during clinical visits and supplemented by chart review...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29655919/endocannabinoid-system-in-systemic-lupus-erythematosus-first-evidence-for-a-deranged-2-arachidonoylglycerol-metabolism
#18
Luca Navarini, Tiziana Bisogno, Pamela Mozetic, Fabiana Piscitelli, Domenico Paolo Emanuele Margiotta, Fabio Basta, Antonella Afeltra, Mauro Maccarrone
The endocannabinoid (eCB) system plays a key role in many physiological and pathological conditions and its dysregulation has been described in several rheumatological and autoimmune diseases. Yet, its possible alteration in systemic lupus erythematosus (SLE) has never been investigated. Here, we aimed filling this gap in plasma and peripheral blood mononuclear cells (PBMCs) of patients with SLE and age- and sex- matched healthy subjects (HS). Liquid chromatography-mass spectrometry quantitation of eCB levels highlighted that plasma levels of 2-arachidonoylglycerol (2-AG) were significantly increased in SLE patients compared to HS (p = 0...
April 12, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29652832/sympathetic-nerve-hyperactivity-in-the-spleen-causal-for-nonpathogenic-driven-chronic-immune-mediated-inflammatory-diseases-imids
#19
REVIEW
Denise L Bellinger, Dianne Lorton
Immune-Mediated Inflammatory Diseases (IMIDs) is a descriptive term coined for an eclectic group of diseases or conditions that share common inflammatory pathways, and for which there is no definitive etiology. IMIDs affect the elderly most severely, with many older individuals having two or more IMIDs. These diseases include, but are not limited to, type-1 diabetes, obesity, hypertension, chronic pulmonary disease, coronary heart disease, inflammatory bowel disease, and autoimmunity, such as rheumatoid arthritis (RA), Sjőgren's syndrome, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and multiple sclerosis...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29648686/development-and-validation-of-a-novel-evidence-based-lupus-multivariable-outcome-score-for-clinical-trials
#20
Michal Abrahamowicz, John M Esdaile, Rosalind Ramsey-Goldman, Lee S Simon, Vibeke Strand, Peter E Lipsky
BACKGROUND: Trials of new SLE treatments are hampered by the lack of effective outcome measures. To address this, we developed a new Lupus Multivariable Lupus Outcome Score (LuMOS). METHOD: The LuMOS formula was developed by analyzing raw data of two pivotal trials: BLISS-52 and BLISS-76, the basis for approval of belimumab (Bel). Using data from BLISS-76 as the learning dataset, we optimized discrimination between outcomes for patients treated with 10mg/kg Bel versus placebo over the first 52 weeks of follow-up using multivariable logistic regression analyses...
April 12, 2018: Arthritis & Rheumatology
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