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reaction prosthesis prosthetic heart

L Barbarash, I Kudryavtsev, N Rutkovskaya, A Golovkin
The study was aimed at assessing T cell subsets of peripheral blood from recipients of long-term functioning (more than 60 months) biological and mechanical heart valve prostheses. The absolute and relative number of CD4 and CD8 T cell subsets was analyzed: naïve (N, CD45RA(+)CD62L(+)), central memory (CM, CD45RA(-)CD62L(+)), effector memory (EM, CD45RA(-)CD62L(-)), and terminally differentiated CD45RA-positive effector memory (TEMRA, CD45RA(+)CD62L(-)) in 25 persons with biological and 7 with mechanical prosthesis compared with 48 apparently healthy volunteers...
2016: Mediators of Inflammation
Mustafa Ozan Gursoy, Suleyman Karakoyun, Macit Kalcik, Mahmut Yesin, Sabahattin Gunduz, Mehmet Ali Astarcioğlu, Ali Emrah Oğuz, Mehmet Ozkan
BACKGROUND AND AIM OF THE STUDY: Prosthetic valve dysfunction (PVD) due to pannus formation is considered to occur due to a bioreaction to prosthetic material. The p53 gene plays a critical role in apoptosis and cell proliferation. p53 Arg72Pro polymorphism has been found to be associated with coronary stent restenosis, but has not yet been studied in prosthetic heart valve dysfunction. The study aim was to evaluate the association between pannus-derived PVD and p53 G72C(Arg72Pro) polymorphism...
September 2015: Journal of Heart Valve Disease
A C Cheung, S Banerjee, J J Cherian, F Wong, J Butany, C Gilbert, C Overgaard, K Syed, M G Zywiel, J J Jacobs, M A Mont
UNLABELLED: Recently, the use of metal-on-metal articulations in total hip arthroplasty (THA) has led to an increase in adverse events owing to local soft-tissue reactions from metal ions and wear debris. While the majority of these implants perform well, it has been increasingly recognised that a small proportion of patients may develop complications secondary to systemic cobalt toxicity when these implants fail. However, distinguishing true toxicity from benign elevations in cobalt ion levels can be challenging...
January 2016: Bone & Joint Journal
Coralie Bouchiat, Julien Saison, Sandrine Boisset, Jean-Pierre Flandrois, Bertrand Issartel, Olivier Dauwalder, Yvonne Benito, Sophie Jarraud, Jacqueline Grando, Andre Boibieux, Oana Dumitrescu, François Delahaye, Fadi Farhat, Françoise Thivolet-Bejui, Jean-Philippe Frieh, François Vandenesch
Background.  Atypical mycobacteria, or nontuberculous mycobacteria (NTM), have been barely reported as infective endocarditis (IE) agents. Methods.  From January 2010 to December 2013, cardiac valve samples sent to our laboratory as cases of blood culture-negative suspected IE were analyzed by 16S rDNA polymerase chain reaction (PCR). When positive for NTM, hsp PCR allowed species identification. Demographic, clinical, echocardiographic, histopathological, and Ziehl-Neelsen staining data were then collected...
April 2015: Open Forum Infectious Diseases
Min-Seok Kim, Hyoung Woo Chang, Seung-Pyo Lee, Dong Ki Kang, Eui-Chong Kim, Ki-Bong Kim
Eleven years ago, a 27-year-old non-drug abuser woman was admitted to the hospital due to a burn injury. During the treatment, she was diagnosed with tricuspid valve infective endocarditis caused by multi-drug resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa). She underwent tricuspid valve replacement (TVR) using a bioprosthetic valve, followed by 6 weeks of meropenem antibiotic therapy. Ten years later, she was again diagnosed with prosthetic valve infective endocarditis caused by MDR P. aeruginosa. She underwent redo-TVR with a bioprosthetic valve and was treated with colistin and ciprofloxacin...
June 9, 2015: Journal of Cardiothoracic Surgery
Robert W Jordan, Adnan Saithna, Nicholas Smith, Rory Norris, Andrew Sprowson, Pedro Foguet
OBJECTIVES: Biofilm formation reduces the efficacy of standard microbiological techniques in prosthetic joint infection. This study aimed to investigate the sensitivity, specificity and predictive values of tissue sample enrichment as a means to increase diagnostic yield. METHODS: Patients undergoing revision arthroplasty surgery between May 2004 and January 2013 had intraoperative tissue samples cultured in standard media as well as enriched in brain heart infusion broth...
May 2015: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Meena S Ramchandani, Robert M Rakita, Rosario V Freeman, Wayne C Levy, Peter Von Homeyer, Nahush A Mokadam
We report a rare case of a patient with prosthetic valve endocarditis (PVE) requiring implantation of a total artificial heart (TAH) as a bridge to heart transplantation. Gemella haemolysans, an unusual cause of PVE, was identified as the organism responsible only by 16s rRNA polymerase chain reaction analysis of surgical tissue samples. We also describe one of the first uses of combined TAH and veno-venous extracorporeal membrane oxygenation therapy in the setting of severe respiratory and cardiac failure...
July 2014: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Michele Bartoletti, Fabio Tumietto, Giovanni Fasulo, Maddalena Giannella, Francesco Cristini, Rachele Bonfiglioli, Luigi Raumer, Cristina Nanni, Silvia Sanfilippo, Marco Di Eusanio, Pier Giorgio Scotton, Maddalena Graziosi, Claudio Rapezzi, Stefano Fanti, Pierluigi Viale
BACKGROUND: The diagnosis of prosthetic valve endocarditis is challenging. The gold standard for prosthetic valve endocarditis diagnosis is trans-esophageal echocardiography. However, trans-esophageal echocardiography may result in negative findings or yield images difficult to differentiate from thrombus in patients with prosthetic valve endocarditis. Combined computed tomography and fluorodeoxyglucose positron emission tomography is a potentially promising diagnostic tool for several infectious conditions and it has also been employed in patients with prosthetic valve endocarditis but data are still scant...
January 13, 2014: BMC Research Notes
B G Iskenderov, D A Vasil'ev
In 42 patients with rheumatic heart defects before implantation of mechanical valves and on days 5 and 20 after surgery we measured parameters of hemostasis, levels of proinflammatory cytokines (interleukin 6 [IL-6], tumor necrosis factor- [TNF-] and C-reactive protein [CRP]) as well as activity of enzymes (alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, creatine phosphokinase and its MB fraction). On day 5 after surgery we revealed substantial elevation of IL-6, TNF-, and CRP levels, increase of activity of the studied enzymes, contents of fibrinogen and soluble fibrin monomer complexes (SFMC), and to the contrary lowering of antithrombin III level and decrease of number of platelets...
2013: Kardiologiia
Jamil Hajj-Chahine, Hassan Houmaida, Chloé Plouzeau, Jacques Tomasi, Pierre Corbi
Bartonella henselae infection is typically associated with cat scratch disease. This microorganism can also lead to culture-negative infective endocarditis in immunocompromised patients. We present a rare case of a previously healthy 65-year-old man with B. henselae-associated endocarditis of a prosthetic aortic root. All blood cultures, as well as cultures of the resected aortic valve vegetations, remained negative. Polymerase chain reaction with specific bacterial primers with DNA sequencing was used to identify B...
April 2012: Annals of Thoracic Surgery
Attila Cziráki, Zénó Ajtay, Agnes Nagy, László Márton, Zsófia Verzár, Sándor Szabados
Heparin-induced thrombocytopenia (HIT) is one of the most common immune-mediated adverse drug reactions, with frequencies as high as 2-3% for certain groups of post-cardiac surgery patients. We report on an 50-year-old woman with early post-operative thrombosis of the prosthetic mitral valve due to heparin-induced thrombocytopenia. Non-invasive imaging (two-dimensional transesophageal echocardiography; 2D-TEE) allowed the exact localisation of thrombotic masses and revealed the increase of the mean diastolic mitral gradient...
2012: Journal of Cardiothoracic Surgery
Gennaro Mazzarella, Andrea Bianco, Angela Lucariello, Leonilde Savarese, Angelamaria Fiumarella, Flavio Cerasuolo, Franca Ferraraccio, Antonio De Luca
Cardiac valves have a very complex microscopic architecture, this is due to the presence of many cell types and to the variegated stroma. From a morphological point of view, both physiological and pathological processes clearly show there to be an anatomic continuity between valve leaflets and perivalvular tissues; indeed, both component should be taken into consideration during thrombotic processes and in fibrous tissue formation. At present, morphological features are well known and classified, while little is known about histogenetic features: fibrous tissue formation and the role of the various types of adhesion molecules and cells which participate in this process still have to be fully elucidated...
March 2012: In Vivo
Massimo Imazio, Enrico Cecchi, Rita Trinchero
No abstract text is available yet for this article.
May 2010: Heart: Official Journal of the British Cardiac Society
Franck Thuny, Pierre-Edouard Fournier, Jean-Paul Casalta, Frédérique Gouriet, Hubert Lepidi, Alberto Riberi, Frédéric Collart, Gilbert Habib, Didier Raoult
Context Early prosthetic valve endocarditis is a deadly disease and blood cultures remain negative in 14-30% of cases. Objectives To analyse the clinical and microbiological profile of patients with blood culture-negative (BCN) early prosthetic valve endocarditis (PVE) in order to define the most appropriate empiric treatment. Design, Setting and Participants From June 2001 to February 2009, a prospective multimodal strategy incorporating serological, molecular and histopathological assays was performed in all the samples referred to the laboratory for a suspicion of blood culture-negative endocarditis (BCNE) from France and abroad (n=718)...
May 2010: Heart: Official Journal of the British Cardiac Society
N A Khan, J Butany, S W Leong, V Rao, R J Cusimano, H J Ross
Prosthetic heart valve dysfunction due to thrombus or pannus formation can be a life-threatening complication. The present report describes a 47-year-old woman who developed valvular cardiomyopathy after chorda-sparing mitral valve replacement, and subsequently underwent heart transplantation for progressive heart failure. The explanted mitral valve prosthesis showed significant thrombus and pannus leading to reduced leaflet mobility and valvular stenosis. The present report illustrates the role of the subvalvular apparatus and pannus in prosthesis dysfunction...
March 2009: Canadian Journal of Cardiology
O V Zhirekhina, A B Chukhlovin, K A Sysoev, V V Gritsenko, A A Totolian
Infectious endocarditis can be caused by various microorganisms. Diagnostics of local infection by microbiological methods is not always effective. For that reason we performed a study aimed for direct detection of potential infectious agents by polymerase chain reaction in patients' heart valve tissue. DNA of infectious agents was revealed in 72% of heart valve tissue samples from patients with septic endocarditis; in studied samples, along with bacterial DNA, herpesviruses' DNA was detected. Obtained results confirm the presence of infection, which allows to perform specific diagnostics of infectious complications after implantation of prosthetic cardiac valves...
July 2008: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Nasir A Khan, Jagdish Butany, Taylor Zhou, Heather J Ross, Vivek Rao
AIMS: Ventricular assist devices (VADs) are now a mainstay in the management of patients with end-stage heart failure. An important consideration in the long-term durability of these devices is the structural integrity of the prosthetic valves. Herein, we report the morphological findings in inflow and outflow explanted bioprostheses from seven such devices. METHODS: The porcine bioprostheses (n = 7; HeartMate, Novacor) were examined from inflow and outflow valve conduits...
June 2008: Pathology
Risa M Hoffman, Jamil AboulHosn, John S Child, David A Pegues
Bartonella species are an important cause of culture-negative endocarditis, with recognized risk factors of alcoholism, homelessness, cat exposure, and pre-existing valvular disease. We report a case of Bartonella henselae endocarditis in a 36-year-old woman with complex congenital heart disease who presented with a 7-month history of hemolytic anemia, leukocytoclastic vasculitis, and recurrent fevers. Transesophageal echocardiogram revealed vegetations on the patient's native aortic valve and in the right ventricular to pulmonary artery conduit and associated bioprosthetic valve...
January 2007: Congenital Heart Disease
Tadahisa Sugiura, Masaaki Koide, Yoshifumi Kunii, Nobuhiro Umehara
No abstract text is available yet for this article.
May 2008: European Journal of Cardio-thoracic Surgery
James W Little, Donald A Falace, Craig S Miller, Nelson L Rhodus
Antibiotics are used in dentistry to treat an existing infection therapeutically or to prevent an infection prophylactically. To prevent a perioperative infection (primary prophylaxis), prophylactic antibiotics may be administered when a surgical device, such as a prosthetic cardiac valve, is placed. They also may be administered to patients who have an existing medical condition or have received a previously placed device to reduce the risk of infection from a bacteremia (secondary prophylaxis). Although it is common to prescribe secondary prophylaxis for many dental conditions, there is a general lack of scientific evidence of its effectiveness and accumulating evidence suggests that such prescriptions may be unnecessary...
January 2008: General Dentistry
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