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reaction prosthesis heart

L Barbarash, I Kudryavtsev, N Rutkovskaya, A Golovkin
The study was aimed at assessing T cell subsets of peripheral blood from recipients of long-term functioning (more than 60 months) biological and mechanical heart valve prostheses. The absolute and relative number of CD4 and CD8 T cell subsets was analyzed: naïve (N, CD45RA(+)CD62L(+)), central memory (CM, CD45RA(-)CD62L(+)), effector memory (EM, CD45RA(-)CD62L(-)), and terminally differentiated CD45RA-positive effector memory (TEMRA, CD45RA(+)CD62L(-)) in 25 persons with biological and 7 with mechanical prosthesis compared with 48 apparently healthy volunteers...
2016: Mediators of Inflammation
Mustafa Ozan Gursoy, Suleyman Karakoyun, Macit Kalcik, Mahmut Yesin, Sabahattin Gunduz, Mehmet Ali Astarcioğlu, Ali Emrah Oğuz, Mehmet Ozkan
BACKGROUND AND AIM OF THE STUDY: Prosthetic valve dysfunction (PVD) due to pannus formation is considered to occur due to a bioreaction to prosthetic material. The p53 gene plays a critical role in apoptosis and cell proliferation. p53 Arg72Pro polymorphism has been found to be associated with coronary stent restenosis, but has not yet been studied in prosthetic heart valve dysfunction. The study aim was to evaluate the association between pannus-derived PVD and p53 G72C(Arg72Pro) polymorphism...
September 2015: Journal of Heart Valve Disease
A C Cheung, S Banerjee, J J Cherian, F Wong, J Butany, C Gilbert, C Overgaard, K Syed, M G Zywiel, J J Jacobs, M A Mont
UNLABELLED: Recently, the use of metal-on-metal articulations in total hip arthroplasty (THA) has led to an increase in adverse events owing to local soft-tissue reactions from metal ions and wear debris. While the majority of these implants perform well, it has been increasingly recognised that a small proportion of patients may develop complications secondary to systemic cobalt toxicity when these implants fail. However, distinguishing true toxicity from benign elevations in cobalt ion levels can be challenging...
January 2016: Bone & Joint Journal
Simon J Sonntag, Maximilan Kütting, Pejman Farhadi Ghalati, Tim Kaufmann, Jaime Vázquez-Jiménez, Ulrich Steinseifer, Janez Vodiskar
PURPOSE: Implanting the largest valved conduit possible - oversizing - to reconstruct an absent connection from the right ventricle to the pulmonary artery in certain types of congenital heart defects has been suggested as a compensating measure for somatic outgrowth of the patient. However, one effect that has not been investigated yet is the hemodynamic consequence. For this purpose, virtual implantation and flow simulations were conducted in this study. METHODS: To isolate the effects of conduit oversizing on the hemodynamics observed after conduit implantation and outgrowth, calculated wall shear stresses (WSS) of image-based computational fluid dynamic (CFD) simulations were used as indicators...
October 2015: International Journal of Artificial Organs
Robert A Dion
The tricuspid valve has been recently referred to as the "forgotten valve," because one now realizes that tricuspid regurgitation is bad for the patient and that reoperation for progressive tricuspid regurgitation after a left-sided valvular correction still carries a high mortality risk. However, the indication for concomitant tricuspid valve repair during a mitral valve repair procedure is still controversial, as illustrated by the reaction of Dr T. David to the presentation of Dr Chikwe and colleagues at the 2015 American Association for Thoracic Surgery meeting...
November 2015: Journal of Thoracic and Cardiovascular Surgery
Marián Kurečko, Gabriel Valočik, Marianna Vachalcová, Mariana Dvorožňáková
Transcatheter aortic valve implantation (TAVI) is an interventional method for the treatment of severe aortic stenosis. TAVI is indicated in patients who have been identified by the heart team as surgically inoperable or operable at very high risk. The advantage is minimal invasive approach with the absence of sternotomy and extracorporeal blood circulation. Interventional procedure does not allow direct visualization of the anatomical relations at the site of the final valve position (aortic anulus). For this reason it is essential to ensure appropriate view by high quality imaging methods...
July 2015: Vnitr̆ní Lékar̆ství
Yang Gao, Rimao Huang, Ri Chen, Jun Li, Wanjun Luo
BACKGROUND: Although the involvement of microRNAs (miRNAs) has been intensively studied in myocardial infarction, there is no report on the regulation of miRNAs by ischemic postconditioning in patients undergoing cardiac surgery. We aim to explore the regulation of miRNAs by ischemic postconditioning in double valve replacement. MATERIALS AND METHODS: In this prospective, controlled clinical study, consecutive 30 patients undergoing double valve replacement were enrolled...
January 2016: Journal of Surgical Research
Coralie Bouchiat, Julien Saison, Sandrine Boisset, Jean-Pierre Flandrois, Bertrand Issartel, Olivier Dauwalder, Yvonne Benito, Sophie Jarraud, Jacqueline Grando, Andre Boibieux, Oana Dumitrescu, François Delahaye, Fadi Farhat, Françoise Thivolet-Bejui, Jean-Philippe Frieh, François Vandenesch
Background.  Atypical mycobacteria, or nontuberculous mycobacteria (NTM), have been barely reported as infective endocarditis (IE) agents. Methods.  From January 2010 to December 2013, cardiac valve samples sent to our laboratory as cases of blood culture-negative suspected IE were analyzed by 16S rDNA polymerase chain reaction (PCR). When positive for NTM, hsp PCR allowed species identification. Demographic, clinical, echocardiographic, histopathological, and Ziehl-Neelsen staining data were then collected...
April 2015: Open Forum Infectious Diseases
Pamela Somers, Annelies Roosens, Filip De Somer, Maria Cornelissen, Guido Van Nooten
BACKGROUND AND AIM OF THE STUDY: Currently, no effective crosslinking reagents are available to treat xenogenic decellularized heart valve matrices. The study aim was to evaluate the crosslinking effect of quercetin, catechin, caffeic acid and tannic acid on porcine aortic valve matrices. METHODS: Cytotoxicity of the different crosslinkers was evaluated. The mechanical properties of crosslinked porcine matrices and control matrices (non-fixed) were examined by tensile strength testing, as was the cytocompatibility of the fixed matrices...
January 2015: Journal of Heart Valve Disease
Min-Seok Kim, Hyoung Woo Chang, Seung-Pyo Lee, Dong Ki Kang, Eui-Chong Kim, Ki-Bong Kim
Eleven years ago, a 27-year-old non-drug abuser woman was admitted to the hospital due to a burn injury. During the treatment, she was diagnosed with tricuspid valve infective endocarditis caused by multi-drug resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa). She underwent tricuspid valve replacement (TVR) using a bioprosthetic valve, followed by 6 weeks of meropenem antibiotic therapy. Ten years later, she was again diagnosed with prosthetic valve infective endocarditis caused by MDR P. aeruginosa. She underwent redo-TVR with a bioprosthetic valve and was treated with colistin and ciprofloxacin...
2015: Journal of Cardiothoracic Surgery
Frances Rosario-Quinones, Margret S Magid, Jen Yau, Amit Pawale, Khanh Nguyen
BACKGROUND: Decellularized porcine small intestine submucosa (CorMatrix, Atlanta, GA) patches have been used in the repair of congenital heart malformations. Tissue reaction to the material may create hemodynamic dysfunction and necessitate explantation. We reviewed our series of congenital cardiac patients who had a reoperation after the implantation of CorMatrix patches. METHODS: Medical records of pediatric cardiac patient who received CorMatrix patches and those of patients who underwent reoperation were reviewed...
April 2015: Annals of Thoracic Surgery
Torsten Christ, Pascal M Dohmen, Sebastian Holinski, Melanie Schönau, Georg Heinze, Wolfgang Konertz
BACKGROUND: Tissue engineering (TE) is a promising approach to overcome problems associated with biological heart valve prosthesis. Currently several animal models are used to advance this method. The rat subdermal model is uncomplicated and widely used, but its suitability for TE has not yet been shown. MATERIAL AND METHODS: Using the rat subdermal model we implanted two decellularized porcine aortic wall specimens (of which one was endothelialized) and one native porcine aortic wall specimen in 30 Lewis rats, respectively...
2014: Medical Science Monitor Basic Research
Myriam Amsallem, Bernard Iung, Claire Bouleti, Laurence Armand-Lefevre, Anne-Line Eme, Aziza Touati, Matthias Kirsch, Xavier Duval, Alec Vahanian
A 65 year-old woman was admitted for acute heart failure and severe sepsis revealing definite mitral infective endocarditis with severe regurgitation, complicated by multiple embolisms. Three blood cultures yielded a group G Streptococcus canis strain. Urgent surgery was performed with bioprosthetic valve replacement. Polymerase chain reaction analysis of the valve found S canis DNA. Amoxicillin and gentamicin were given for 2 weeks followed by 4 weeks of amoxicillin alone. She reported contact with a dog without bite...
November 2014: Canadian Journal of Cardiology
Robert W Jordan, Adnan Saithna, Nicholas Smith, Rory Norris, Andrew Sprowson, Pedro Foguet
OBJECTIVES: Biofilm formation reduces the efficacy of standard microbiological techniques in prosthetic joint infection. This study aimed to investigate the sensitivity, specificity and predictive values of tissue sample enrichment as a means to increase diagnostic yield. METHODS: Patients undergoing revision arthroplasty surgery between May 2004 and January 2013 had intraoperative tissue samples cultured in standard media as well as enriched in brain heart infusion broth...
May 2015: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Thomas Strecker, Johannes Rösch, Michael Weyand, Abbas Agaimy
BACKGROUND AND AIM: Ventricular assist devices (VAD) have become an established therapy for patients with end-stage heart failure. The two main reasons for this development are the shortage of appropriate donor organs and the increasing number of patients waiting for heart transplantation (HTX). Furthermore, the enormous advances in the technical equipment and the rising clinical experience have improved the implantation technique, the durability and the long-term patient outcomes. METHODS: We reviewed all cases of left ventricular assist device (LVAD) implantation at our Erlangen Heart Center during January 2000-July 2013...
2014: International Journal of Clinical and Experimental Pathology
Hong-Gook Lim, Gi Beom Kim, Saeromi Jeong, Yong Jin Kim
OBJECTIVES: Conventional crosslinking with glutaraldehyde (GA) renders cardiac xenografts inert, non-biodegradable and non-antigenic, but is a main cause for dystrophic calcification due to phospholipids, free aldehyde groups and residual antigenicity. A significant immune reaction to the galactose-α-1,3 galactose β-1,4-N-acetylglucosamine (α-Gal) of a GA-fixed cardiac xenograft occurs, leading to calcification. We developed a next-generation α-Gal-free tissue valve with GA-fixed cardiac xenografts, treated using a novel combined anticalcification protocol including immunological modification, which was demonstrated effective in a small animal study...
July 2015: European Journal of Cardio-thoracic Surgery
Brian R Englum, Elizabeth N Pavlisko, Molly C Mack, Asvin M Ganapathi, Matthew A Schechter, Jennifer M Hanna, G Chad Hughes
BACKGROUND: A growing literature describes aneurysmal deterioration after implantation of the stentless porcine aortic Medtronic Freestyle bioprosthesis (MFB; Medtronic Inc, Minneapolis, MN), with some suggesting inadequate tissue fixation with immune response as a cause. However, disjointed reports make the significance of these findings difficult to interpret. We address this concern by aggregating available data. METHODS: We reviewed institutional data, the Food and Drug Administration's Manufacturer and User Facility Device Experience registry, and the medical literature for mention of aneurysm or pseudoaneurysm after MFB...
December 2014: Annals of Thoracic Surgery
V P Sitnikov, S V Shil'ko, Él'-Refaĭ Khusam, É A Nadyrov, V P Kazachenko, N T Dzhaĭnakbaev
The objective of the present study was to elucidate general and local characteristics of the tissue reactions to the implantation of radiation-modified polytetrafluoroethylene (PTFE)-based fluoroplast F-4PM20 with a diamond-like carbon (DLC) nanocoating or with the diamond-like carbon coating containing the dispersed nano-sized silver particles to the experimental animals (rats). A total of 150 inbred white rats were included into the experiment; they were divided into 3 groups comprised of 50 animals each...
2014: Vestnik Otorinolaringologii
Hong-Gook Lim, Sun Young Choi, Saeromi Jeong, Jun-Seop Shin, Chung-Gyu Park, Yong Jin Kim
The animal immune response against Galα1,3-Galβ1-4GlcNAc-R(α-Gal) epitopes gives an important cause for the failure of glutaraldehyde(GA)-fixed cardiac xenografts. This study aimed to assess the in vivo effect of our novel combined anticalcification treatment, which includes immunologic modification, using α1,3-galactosyltransferase knock-out mice to mimic human immunologic environment. Bovine pericardia were cross-linked with GA and treated with decellularization, immunologic modification with α-galactosidase, space-filler with polyethylene glycol, organic solvent, and detoxification...
February 2015: Journal of Biomaterials Applications
Michel Wolff, Bruno Mourvillier, Romain Sonneville, Jean-François Timsit
INTRODUCTION: Although the recent literature contains plenty of studies concerning all aspects of infective endocarditis (IE), very few focus on severe IE requiring admission to the ICU. RESULTS: In 2004, we published a report on the clinical spectrum and prognostic factors in 228 consecutive critically ill patients with IE. Septic shock, neurological complications and immunocompromised state were independently associated with in-hospital mortality. Cardiac surgery during the acute phase of EI was associated with better survival...
December 2014: Intensive Care Medicine
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