Vera Beckert, Sebastian Rassmann, Amir Hossein Kayvanjoo, Christina Klausen, Lorenzo Bonaguro, Dominik Simon Botermann, Melanie Krause, Kristin Moreth, Nadine Spielmann, Patricia da Silva-Buttkus, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis, Kristian Händler, Thomas Ulas, Anna C Aschenbrenner, Elvira Mass, Dagmar Wachten
CRELD1 (Cysteine-Rich with EGF-Like Domains 1) is a risk gene for non-syndromic atrioventricular septal defects in human patients. In a mouse model, Creld1 has been shown to be essential for heart development, particularly in septum and valve formation. However, due to the embryonic lethality of global Creld1 knockout (KO) mice, its cell type-specific function during peri- and postnatal stages remains unknown. Here, we generated conditional Creld1 KO mice lacking Creld1 either in the endocardium (KOTie2 ) or the myocardium (KOMyHC )...
March 24, 2021: Journal of Molecular and Cellular Cardiology