Ying Lin, Qifan Yang, Xiaoping Lin, Xianbao Liu, Yi Qian, Dilin Xu, Naifang Cao, Ximeng Han, Yanqing Zhu, Wangxing Hu, Xiaopeng He, Zhengyang Yu, Xiangmin Kong, Lianlian Zhu, Zhiwei Zhong, Kai Liu, Bin Zhou, Yidong Wang, Jinrong Peng, Wei Zhu, Jian'an Wang
BACKGROUND: A better understanding of the molecular mechanism of aortic valve development and bicuspid aortic valve (BAV) formation would significantly improve and optimize the therapeutic strategy for BAV treatment. Over the past decade, the genes involved in aortic valve development and BAV formation have been increasingly recognized. On the other hand, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) gene family members have been reported to be able to modulate cardiovascular development and diseases...
November 29, 2023: Circulation