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antibiotics in pregnancy

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https://www.readbyqxmd.com/read/28645088/risk-based-screening-combined-with-a-pcr-based-test-for-group-b-streptococci-diminishes-the-use-of-antibiotics-in-laboring-women
#1
Mohammed R Khalil, Niels Uldbjerg, Poul B Thorsen, Birgitte Henriksen, Jens K Møller
OBJECTIVE: To assess the performance of a polymerase chain reaction - group B streptococci test (PCR-GBS test) - in deciding antibiotic prophylaxis in term laboring women. STUDY DESIGN: In this observational study, we enrolled 902 unselected Danish term pregnant women. During labor, midwives obtained vaginal swabs that were used for both GBS cultures (reference standard) and for the PCR-GBS test. Furthermore, we recorded the presence of risk factors for EOGBS (Early Onset Group B Streptococcal disease): (1) Bacteriuria during current pregnancy, (2) Prior infant with EOGBS (3) Temperature above 38...
June 9, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28635531/drug-exposure-in-early-pregnancy-might-be-related-to-the-effects-of-increased-maternal-progesterone-in-implantation-period
#2
Necip Girit, Ibrahim Tugrul, Buket Demirci, Ozlem Bozkurt, Turhan Dost, Mustafa Birincioglu, H Alper Tanriverdi
AIM: This short communication aims to evaluate the relation in between drug exposure time and early pregnancy regarding gestational weeks. METHODS: The study covers the referrals made to the Department of Pharmacology for a teratogenic consultation in a 3-year period. From the recordings of pregnant women, the last menstrual period and the starting date of medication were used to determine the time of prescription with regard to gestational weeks. RESULTS: In all of the three years, potentially teratogenic medication was prescribed more frequently in the 3rd, 4th and 5th gestational weeks (in between 15-35 days of pregnancy)...
February 15, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28633864/perinatal-group-b-streptococcal-infections-virulence-factors-immunity-and-prevention-strategies
#3
REVIEW
Jay Vornhagen, Kristina M Adams Waldorf, Lakshmi Rajagopal
Group B streptococcus (GBS) or Streptococcus agalactiae is a β-hemolytic, Gram-positive bacterium that is a leading cause of neonatal infections. GBS commonly colonizes the lower gastrointestinal and genital tracts and, during pregnancy, neonates are at risk of infection. Although intrapartum antibiotic prophylaxis during labor and delivery has decreased the incidence of early-onset neonatal infection, these measures do not prevent ascending infection that can occur earlier in pregnancy leading to preterm births, stillbirths, or late-onset neonatal infections...
June 17, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28632191/sexually-transmitted-infections-a-novel-screening-strategy-for-improving-women-s-health-in-vulnerable-populations
#4
Elena R Frati, Ester Fasoli, Marianna Martinelli, Daniela Colzani, Silvia Bianchi, Luciana Carnelli, Antonella Amendola, Pierfranco Olivani, Elisabetta Tanzi
BACKGROUND: Migrant women are one of the most vulnerable population to health problems and well-being. This study aimed at implementing a counseling and preventive strategy for sexually transmitted infections (STIs) in undocumented migrant women in Milan, Italy. METHODS: Women (ages 18-65) were enrolled at the NAGA Centre (2012-2013) and asked for a urine sample in order to carry out molecular detection of Human papillomavirus (HPV), Chlamydia trachomatis (Ct), Trichomonas vaginalis (Tv), Neisseria gonorrhoeae (Ng)-DNA...
June 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28608793/the-immunopathogenesis-of-mycoplasma-genitalium-infections-in-women-a-narrative-review
#5
Patricia M Dehon, Chris L McGowin
Mycoplasma genitalium is a common, predominately asymptomatic, and often undiagnosed sexually transmitted infection that is associated with inflammatory urogenital and reproductive tract disease syndromes of men and women. Without programmatic screening in the United States, and with increasing resistance to antibiotics used in empiric sexually transmitted infection management, undiagnosed M. genitalium infections put many women at risk for cervicitis and pelvic inflammatory disease. Chronic infection may also lead to tubal-factor infertility, adverse pregnancy outcomes in expectant mothers, and is a risk factor for acquisition and transmission of human immunodeficiency virus...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28602871/outcomes-of-antibiotic-therapy-for-uncomplicated-appendicitis-in-pregnancy
#6
Jeong Il Joo, Hyoung-Chul Park, Min Jeong Kim, Bong Hwa Lee
OBJECTIVE: The aim of the present study is to determine the feasibility and safety of antibiotics for uncomplicated simple appendicitis in pregnancy. METHOD: Ours was a 6-year prospective observational study conducted on 20 pregnant women in whom uncomplicated simple appendicitis (appendiceal diameter ≤ 11 mm and without any signs of appendicoliths, perforation, or abscess) was radiologically verified and managed with a 4-day course of antibiotics. Treatment failure rate, defined as the need for an appendectomy during hospitalization and recurrence in the follow-up period (median 25 months), and maternal or fetal complications during the pregnancy were evaluated...
June 8, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28601159/abnormal-pregnancies-associated-with-deviation-in-progestin-and-estrogen-profiles-in-late-pregnant-mares-a-diagnostic-aid
#7
Mitsumori Shikichi, Katsuroku Iwata, Katsumi Ito, Daisuke Miyakoshi, Harutaka Murase, Fumio Sato, Kenji Korosue, Shunichi Nagata, Yasuo Nambo
Measurement of progestines and estrogens in maternal plasma has been advocated as an indicator of foeto-placental function. The goals of the present study were as follows: to determine progestin and estrogen concentrations in mares with normal and abnormal pregnancies during late gestation, evaluate the diagnostic value of hormone concentrations, and investigate the relationship between hormone concentrations after treatment and the survival of foals. Blood samples were collected monthly from 459 pregnant mares between Day 201 of gestation and foaling...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28600919/group-a-streptococci-infection-a-systematic-clinical-review-exemplified-by-cases-from-an-obstetric-department
#8
REVIEW
Line Winther Gustafson, Jan Blaakær, Rikke Bek Helmig
Group A streptococci infection has re-emerged since the 1980s and onward, despite the awareness of the etiology and the use of penicillin. It now accounts for more than 75,000 deaths worldwide every year. Postpartum women have a 20-fold increased incidence of group A streptococci disease compared to non-pregnant women. This review focuses on the epidemiology, pathophysiology, clinical presentation, prevention and treatment of group A streptococcal infection in pregnancy. SEARCH STRATEGY: We searched the following electronic databases from 1980-March 2016: PubMed-Medline, Embase, SveMed+, Bibliotek...
June 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28589214/-individualized-treatment-strategies-for-clostridium-difficile-infections
#9
REVIEW
P Solbach, P Dersch, O Bachmann
Upon hospitalization, up to 15.5% of patients are already colonized with a toxigenic Clostridium difficile strain (TCD). The rate of asymptomatic colonization is 0-3% in healthy adults and up to 20-40% in hospitalized patients. The incidence and mortality of C. difficile infection (CDI) has significantly increased during recent years. Mortality lies between 3 and 14%. CDI is generally caused by intestinal dysbiosis, which can be triggered by various factors, including antibiotics or immune suppressants. If CDI occurs, ongoing antibiotic therapy should be discontinued...
June 6, 2017: Der Internist
https://www.readbyqxmd.com/read/28562753/group-b-streptococcus-detection-in-pregnant-women-via-culture-and-pcr-methods
#10
Cláudia Wollheim, Rosa Dea Sperhacke, Sabrina Kahler Ribeiro Fontana, Andréa Cristina Vanni, Sérgio Kakuta Kato, Patricia Regina de Araújo, Afonso Luis Barth, José Mauro Madi
INTRODUCTION: Group B Streptococcus (GBS), a source of neonatal infection, colonizes the gastrointestinal and genitourinary tracts of pregnant women. Routine screening for maternal GBS in late pregnancy and consequent intrapartum antibiotic prophylaxis have reduced the incidence of early-onset GBS neonatal infection. The aim of this study was to evaluate the performance of PCR, compared to culture (gold standard), in GBS colonization screening of pregnant women, and to establish the prevalence of GBS colonization among this population...
March 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28550827/randomized-controlled-trial-for-helicobacter-pylori-eradication-in-a-naive-portuguese-population-is-sequential-treatment-superior-to-triple-therapy-in-real-world-clinical-setting
#11
Pedro Boal Carvalho, Joana Magalhães, Francisca Dias de Castro, Bruno Rosa, José Cotter
INTRODUCTION: Helicobacter pylori eradication has become increasingly difficult as resistances to several antibiotics develop. We aimed to compare Helicobacter pylori eradication rates between triple therapy and sequential therapy in a naive Portuguese population. MATERIAL AND METHODS: Prospective randomized trial including consecutive patients referred for first-line Helicobacter pylori eradication treatment. EXCLUSION CRITERIA: previous gastric surgery/neoplasia, pregnancy/lactancy, allergy to any of the drugs...
March 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28536957/brief-report-association-between-autism-spectrum-disorder-gastrointestinal-problems-and-perinatal-risk-factors-within-sibling-pairs
#12
Johan Isaksson, Erik Pettersson, Elzbieta Kostrzewa, Rochellys Diaz Heijtz, Sven Bölte
Autism spectrum disorder (ASD) has been associated with gastrointestinal (GI) problems, but the nature of this association is unclear. Parents to siblings, concordant or discordant for ASD (N = 217), participated in a web survey covering mother's weight gain during pregnancy, maternal viral/bacterial infection and use of antibiotics, duration of breastfeeding, mode of delivery, birth weight and child GI problems. ASD was associated with GI problems and perinatal environmental risk, based on a summation of maternal infection and antibiotic use during pregnancy and/or the breastfeeding period...
May 23, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28523055/antibiotics-and-over-the-counter-medication-use-and-its-correlates-among-arab-pregnant-women-visiting-a-tertiary-care-hospital-in-riyadh-saudi-arabia
#13
Hafsa Raheel, Sulaiman Alsakran, Abdulkhaliq Alghamdi, Majed Ajarem, Salman Alsulami, Afzal Mahmood
BACKGROUND AND OBJECTIVE: The use of over the counter medications (OTCMs) is a common practice globally. OTCMs are of special concern among pregnant women as they pose risk to the mother and fetus. The objective was to assess the use of OTCMs by pregnant woman, and factors associated with it. METHODS: A cross-sectional study, using a structured self-administrated questionnaire was conducted at the obstetric and antenatal clinics at King Khalid University hospital, Riyadh...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28512085/self-reported-outcomes-and-adverse-events-after-medical-abortion-through-online-telemedicine-population-based-study-in-the-republic-of-ireland-and-northern-ireland
#14
Abigail R A Aiken, Irena Digol, James Trussell, Rebecca Gomperts
Objectives To assess self reported outcomes and adverse events after self sourced medical abortion through online telemedicine.Design Population based study.Setting Republic of Ireland and Northern Ireland, where abortion is unavailable through the formal healthcare system except in a few restricted circumstances.Population 1000 women who underwent self sourced medical abortion through Women on Web (WoW), an online telemedicine service, between 1 January 2010 and 31 December 2012.Main outcome measures Successful medical abortion: the proportion of women who reported ending their pregnancy without surgical intervention...
May 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28501367/old-habits-die-hard-retrospective-analysis-of-outcomes-with-use-of-corticosteroids-and-antibiotics-before-embryo-transfer
#15
Leah Kaye, Chantal Bartels, Alison Bartolucci, Lawrence Engmann, John Nulsen, Claudio Benadiva
OBJECTIVE: To evaluate clinical pregnancy rates in embryo transfer (ET) cycles with and without peri-implantation corticosteroid and oral antibiotic administration. DESIGN: Retrospective cohort study. SETTING: University-affiliated in vitro fertilization (IVF) clinic. PATIENT(S): Eight hundred and seventy-six ETs with or without the routine use of methylprednisolone and doxycycline. INTERVENTION(S): Embryo transfer procedures...
June 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28484835/effectiveness-of-the-contemporary-treatment-of-preterm-labor-a-comparison-with-a-historical-cohort
#16
Philipp Wagner, Jiri Sonek, Harald Abele, Loefler Sarah, Markus Hoopmann, Sara Brucker, Qinging Wu, Karl Oliver Kagan
OBJECTIVE: To compare the effectiveness of contemporary treatment of preterm labor to a historical cohort. STUDY DESIGN: Retrospective matched case-control study to compare the outcomes of patients that were treated for preterm labor at the University Hospital of Tuebingen, Germany in 2014/2015 (current treatment cohort) and 2006/2007 (historical cohort). The study included women with singleton gestations who were admitted with the diagnosis of preterm labor between 24 + 0 and 34 + 0 weeks' gestation and a cervical length of ≤15 mm...
May 8, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28483402/doxycycline-for-outpatient-treated-acute-exacerbations-of-copd-a-randomised-double-blind-placebo-controlled-trial
#17
Patricia van Velzen, Gerben Ter Riet, Paul Bresser, Jeroen J Baars, Bob T J van den Berg, Jan W K van den Berg, Paul Brinkman, Jennece W F Dagelet, Johannes M A Daniels, Dewi R G L Groeneveld-Tjiong, René E Jonkers, Coen van Kan, Frans H Krouwels, Karin Pool, Arjan Rudolphus, Peter J Sterk, Jan M Prins
BACKGROUND: Antibiotics do not reduce mortality or short-term treatment non-response in patients receiving treatment for acute exacerbations of COPD in an outpatient setting. However, the long-term effects of antibiotics are unknown. The aim of this study was to investigate if the antibiotic doxycycline added to the oral corticosteroid prednisolone prolongs time to next exacerbation in patients with COPD receiving treatment for an exacerbation in the outpatient setting. METHODS: In this randomised double-blind placebo-controlled trial, we recruited a cohort of patients with COPD from outpatient clinics of nine teaching hospitals and three primary care centres in the Netherlands...
May 5, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28464600/-the-composition-of-gut-microbiota-in-infant-and-its-influencing-factors
#18
W Liu, J Q Feng, A Q Fan, M J Zhang, Y L Zhou, T Liu, Y J Xu
Gut microbiota provide enzymes and additional biochemical metabolic pathways for the host, which together with the host genome and the external environment, influence the body function. The composition of gut microbiota in infant is closely related to health in later life. However, it is influenced by many factors, including delivery mode, feeding pattern, prenatal diet, pregnancy psychology and antepartum antibiotic treatment. Vaginal delivery and breastfeeding is beneficial for shaping gut microbiota, while cesarean section and formula feeding would reduce the amount of gut dominant bacteria...
May 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28451045/-prelabour-rupture-of-membranes-prom-at-term-prognostic-factors-and-neonatal-consequences
#19
Asmama Yasmina, Amina Barakat
Prelabour rupture of membranes (PROM) at term occurs in 5 to 10% of pregnancies. It accounts for a significant proportion of neonatal morbidity and mortality. The aim of this case study was to determine the maternal and obstetric prognostic factors as well as full-term newborns outcomes in pregnancies complicated by prelabour rupture of membranes in patients hospitalized or managed at the outpatient clinic. We conducted a retrospective study of all cases of full-term infants born to mothers whose pregnancy was complicated by PROM, recorded in the neonatology department at the Children's Hospital of Rabat between 1 January and 31 July 2014...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28444157/risk-of-congenital-syphilis-following-treatment-of-maternal-syphilis-results-of-a-congenital-syphilis-control-program-in-china
#20
Fu-Chang Hong, Xiao-Bing Wu, Fan Yang, Li-Na Lan, Yang Guan, Chun-Lai Zhang, Tie-Jian Feng, Ying-Zhou Yang, Yue-Ping Yin, Wei-Ye Yu, Xiang-Sheng Chen
Background.: Early screening for syphilis among pregnant women and the effective treatment of maternal syphilis is fundamental to prevent congenital syphilis (CS). Methods.: We obtained data from the Shenzhen Program for Prevention of Congenital Syphilis (SPPCS) and estimated incidence rates of CS among infants born to syphilis-seropositive women treated with different regimens or untreated for maternal syphilis. Results.: 4746 matched cases of syphilis-seropositive mothers and their infants were included for analyses and 162 infants were diagnosed with CS, providing an overall incidence of 3...
April 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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