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Jama rational

Peter W Jurutka, Ichiro Kaneko, Joanna Yang, Jaskaran S Bhogal, Johnathon C Swierski, Christa R Tabacaru, Luis A Montano, Chanh C Huynh, Rabia A Jama, Ryan D Mahelona, Joseph T Sarnowski, Lisa M Marcus, Alexis Quezada, Brittney Lemming, Maria A Tedesco, Audra J Fischer, Said A Mohamed, Joseph W Ziller, Ning Ma, Geoffrey M Gray, Arjan van der Vaart, Pamela A Marshall, Carl E Wagner
Three unreported analogues of 4-[1-(3,5,5,8,8-pentamethyl-5-6-7-8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), otherwise known as bexarotene, as well as four novel analogues of (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254), are described and evaluated for their retinoid X receptor (RXR) selective agonism. Compound 1 has FDA approval as a treatment for cutaneous T-cell lymphoma (CTCL), although treatment with 1 can elicit side-effects by disrupting other RXR-heterodimer receptor pathways...
November 14, 2013: Journal of Medicinal Chemistry
Sharon M Valente
Patients' end-of-life decisions challenge nurses to improve palliative care, symptom management, and patient advocacy, and examine ethical issues. When terminally ill patients take charge of the last stages of life, they may challenge nurses to reexamine attitudes about lifesaving technology and autonomy and values about preserving life. Staff members can become benevolent and believe that they know what is best despite the patient's independent decisions. When patients unsuccessfully decline continued aggressive, life prolonging strategies, they may decide to hasten dying rather than accept a natural death...
July 2004: Cancer Nursing
P Salama, P Spiegel, M Van Dyke, L Phelps, C Wilkinson
CONTEXT: Since the beginning of the North Atlantic Treaty Organization intervention in Kosovo in June 1999, few objective data have been available on relevant health indicators for the Serbian ethnic minority in Kosovo. OBJECTIVE: To determine the prevalence of undernutrition among Serbian adults aged 60 years or older and psychiatric morbidity among the adult Serbian population in Kosovo. DESIGN, SETTING, AND PARTICIPANTS: A systematic random sample survey of 212 households was conducted between September 27 and October 2, 1999, in Pristina, the capital city, and in 10 towns in the rural municipality of Gnjilane in Kosovo...
August 2, 2000: JAMA: the Journal of the American Medical Association
C A D'Arcy, S McGee
CONTEXT: History taking and physical examination maneuvers, including Tinel and Phalen signs, are widely used for the diagnosis of carpal tunnel syndrome (CTS). OBJECTIVE: To systematically review the precision and accuracy of history taking and physical examination in diagnosing CTS in adults. DATA SOURCES: English-language literature was searched using MEDLINE (January 1966-February 2000) as well as bibliographies of relevant articles. STUDY SELECTION: Studies of patients presenting to clinicians with symptoms suggestive of CTS in which findings from clearly described physical examination maneuvers were independently compared with electrodiagnostic testing...
June 21, 2000: JAMA: the Journal of the American Medical Association
J Rapoport, D Teres, J Steingrub, T Higgins, W McGee, S Lemeshow
CONTEXT: Hemodynamic monitoring of patients with a pulmonary artery catheter is controversial because there are few data confirming its effectiveness, and patient and intensive care unit (ICU) organizational factors associated with its use are unknown. OBJECTIVE: To determine pulmonary artery catheter use in relationship to type of ICU organization and staffing, and patient characteristics, including severity of illness and insurance coverage. DESIGN, SETTING, AND PATIENTS: Retrospective database study of 10,217 nonoperative patients who received treatment at 34 medical, mixed medical and surgical, and surgical ICUs at 27 hospitals during 1998 (patients were enrolled in Project IMPACT)...
May 17, 2000: JAMA: the Journal of the American Medical Association
D L Sackett, S E Straus
CONTEXT: Physicians need easy access to evidence for clinical decisions while they care for patients but, to our knowledge, no investigators have assessed use of evidence during rounds with house staff. OBJECTIVE: To determine if it was feasible to find and apply evidence during clinical rounds, using an "evidence cart" that contains multiple sources of evidence and the means for projecting and printing them. DESIGN: Descriptive feasibility study of use of evidence during 1 month (April 1997) and anonymous questionnaire (May 1997)...
October 21, 1998: JAMA: the Journal of the American Medical Association
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