Mohamed El-Tanani, Syed Arman Rabbani, Rasha Babiker, Imran Rangraze, Sumedha Kapre, Sushesh Srivastsa Palakurthi, Abdullah M Alnuqaydan, Alaa A Aljabali, Manfredi Rizzo, Yahia El-Tanani, Murtaza M Tambuwala
This comprehensive review delves into the pivotal role of the tumor microenvironment (TME) in cancer metastasis and therapeutic response, offering fresh insights into the intricate interplay between cancer cells and their surrounding milieu. The TME, a dynamic ecosystem comprising diverse cellular and acellular elements, not only fosters tumor progression but also profoundly affects the efficacy of conventional and emerging cancer therapies. Through nuanced exploration, this review illuminates the multifaceted nature of the TME, elucidating its capacity to engender drug resistance via mechanisms such as hypoxia, immune evasion, and the establishment of physical barriers to drug delivery...
April 14, 2024: Cancer Letters