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review in critical medicine

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https://www.readbyqxmd.com/read/29649891/erratum
#1
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Singer AE, Ash T, Ochotorena C, Lorenz KA, Chong K, Shreve ST, Ahluwalia SC. A Systematic Review of Family Meeting Tools in Palliative and Intensive Care Settings. Am J Hosp Palliat Care. 2016; 33(8):797-806. (DOI: 10.1177/1049909115594353) It was noted that the following references were duplicated in the above mentioned article. (i) Billings JA, Block SD. The end-of-life family meeting in intensive care part III: A guide for structured discussions. J Palliat Med. 2011;14(9):1058-1064. (ii) Fineberg IC, Kawashima M, Asch SM...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29643049/evaluation-of-technology-enhanced-learning-programs-for-health-care-professionals-systematic-review
#2
REVIEW
Pam Nicoll, Sandra MacRury, Hugo C van Woerden, Keith Smyth
BACKGROUND: Technology-enhanced learning (TEL) programs are increasingly seen as the way in which education for health care professionals can be transformed, giving access to effective ongoing learning and training even where time or geographical barriers exist. Given the increasing emphasis on this mode of educational support for health care practitioners, it is vital that we can effectively evaluate and measure impact to ensure that TEL programs are effective and fit for purpose. This paper examines the current evidence base for the first time, in relation to the evaluation of TEL programs for health care professionals...
April 11, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29629572/anti-cancer-effect-of-toosendanin-and-its-underlying-mechanisms
#3
Sha Zhang, Liang Cao, Zong-Ren Wang, Zhe Li, Jing Ma
Toosendanin (TSN) is a triterpenoid purified from the medicinal herb Melia toosendan Sieb. et Zucc and has been used as an insecticide for decades. Recent studies have attracted increasing interest of TSN due to its novel anti-cancer effect in diverse cancer models. The broad spectrum anti-cancer activity suggests that TSN inhibits multiple pathways/targets that are critical for cancer cell survival and proliferation. Our recent study indicated that TSN has anti-cancer effect in glioblastoma through induction of estrogen receptor β (ERβ) and p53...
April 9, 2018: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29629385/barriers-to-medication-adherence-in-patients-with-hypertension-a-qualitative-study
#4
Arash Najimi, Firoozeh Mostafavi, Gholamreza Sharifirad, Parastoo Golshiri
INTRODUCTION: Barriers to medication adherence in patients with hypertension can have significant differences that made researchers confute to conclude that medication adherence is required to be more explored, and then, beneficial interventions develop to decrease these barriers. Thus, the current study was aimed to identify barriers to adherence in Iranian society. MATERIALS AND METHODS: A qualitative content analysis was carried out. Participants were as follow: Patients with hypertension who had clinic records in the health centers of Isfahan University of Medical Science...
2018: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29627355/contemporary-reviews-in-critical-care-medicine-atrial-fibrillation-in-the-intensive-care-unit
#5
REVIEW
Nicholas A Bosch, Jonathan Cimini, Allan J Walkey
Atrial fibrillation (AF) is the most common arrhythmia encountered in the intensive care unit. Pre-existing AF is highly prevalent among older patients with chronic conditions who are at risk for critical illness, while new-onset AF can be triggered by accelerated atrial remodeling and arrhythmogenic triggers encountered during critical illness. The acute loss of atrial systole and onset of rapid ventricular rates that characterize new-onset AF often lead to decreased cardiac output and hemodynamic compromise...
April 5, 2018: Chest
https://www.readbyqxmd.com/read/29625254/oligoaniline-based-conductive-biomaterials-for-tissue-engineering
#6
REVIEW
Payam Zarrintaj, Behnaz Bakhshandeh, Mohammad Reza Saeb, Farshid Sefat, Iraj Rezaeian, Mohammad Reza Ganjali, Seeram Ramakrishna, Masoud Mozafari
The science and engineering of biomaterials have improved the human life expectancy. Tissue engineering is one of the nascent strategies with an aim to fulfill this target. Tissue engineering scaffolds are one of the most significant aspects of the recent tissue repair strategies; hence, it is imperative to design biomimetic substrates with suitable features. Conductive substrates can ameliorate the cellular activity through enhancement of cellular signaling. Biocompatible polymers with conductivity can mimic the cells' niche in an appropriate manner...
April 3, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29623383/-mechanical-circulatory-support-in-terminal-heart-failure
#7
REVIEW
M Derwall, A Moza, A Brücken
BACKGROUND: After exhaustion of all conservative measures in the treatment of acute and chronic heart insufficiency, there is the possibility to temporarily or permanently support or replace the pump performance of the heart by mechanical circulatory support (MCS) systems. OBJECTIVE: Presentation of the most important cardiac support systems for intensive care medicine, their indications and important risk factors. MATERIAL AND METHODS: Critical review of device manufacturer's specifications, current research and expert opinions...
April 5, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29621583/a-review-of-the-traditional-use-of-southern-african-medicinal-plants-for-the-treatment-of-selected-parasite-infections-affecting-humans
#8
REVIEW
I E Cock, M I Selesho, S F van Vuuren
ETHNOPHARMACOLOGICAL RELEVANCE: Worldwide, more than three billion cases of parasitic disease are reported yearly and it is likely that this figure is substantially under-estimated. Approximately one in six people globally are estimated to be infected with at least one parasite species annually. In South Africa, the prevalence of Schistosoma haematobium (bilharzia) and intestinal worms and helminths are particularly high, especially in children and in crowded or poorer rural communities with inadequate sanitation and nutritional status...
April 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29621311/global-trends-of-local-ecological-knowledge-and-future-implications
#9
Shankar Aswani, Anne Lemahieu, Warwick H H Sauer
Local and indigenous knowledge is being transformed globally, particularly being eroded when pertaining to ecology. In many parts of the world, rural and indigenous communities are facing tremendous cultural, economic and environmental changes, which contribute to weaken their local knowledge base. In the face of profound and ongoing environmental changes, both cultural and biological diversity are likely to be severely impacted as well as local resilience capacities from this loss. In this global literature review, we analyse the drivers of various types of local and indigenous ecological knowledge transformation and assess the directionality of the reported change...
2018: PloS One
https://www.readbyqxmd.com/read/29621027/cardiac-output-monitoring-how-to-choose-the-optimal-method-for-the-individual-patient
#10
Bernd Saugel, Jean-Louis Vincent
PURPOSE OF REVIEW: To review the different methods available for the assessment of cardiac output (CO) and describe their specific indications in intensive care and perioperative medicine. RECENT FINDINGS: In critically ill patients, persistent circulatory shock after initial resuscitation is an indication for the assessment of CO to monitor the response to fluids and vasoactive agents. In patients with circulatory shock associated with right ventricular dysfunction, pulmonary artery hypertension, or acute respiratory distress syndrome, invasive CO monitoring using indicator dilution methods is indicated...
April 4, 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29619627/new-advances-in-acute-postoperative-pain-management
#11
REVIEW
Sukanya Mitra, Daniel Carlyle, Gopal Kodumudi, Vijay Kodumudi, Nalini Vadivelu
PURPOSE OF REVIEW: Postoperative pain remains one of the most common challenges following inpatient and outpatient surgeries. With our advances in modern medicine, pain following surgical procedures still remains a challenge, though significant accomplishments have been made over the past few decades. This article highlights some of the promising new advances and approaches in postoperative pain management. RECENT FINDINGS: Over the last decade, Enhanced Recovery after Surgery (ERAS) pathways and protocols are becoming the benchmark standards for enhancing postoperative recovery...
April 4, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29615035/real-world-evidence-how-pragmatic-are-randomized-controlled-trials-labeled-as-pragmatic
#12
Rafael Dal-Ré, Perrine Janiaud, John P A Ioannidis
INTRODUCTION: Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and they are critical to inform decision-making by patients, clinicians and policy-makers in real-world settings. Pragmatic RCTs assess effectiveness of available medicines, while explanatory RCTs assess efficacy of investigational medicines. Explanatory and pragmatic are the extremes of a continuum. This debate article seeks to evaluate and provide recommendation on how to characterize pragmatic RCTs in light of the current landscape of RCTs...
April 3, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29611534/calcium-as-a-signal-integrator-in-developing-epithelial-tissues
#13
Pavel Brodskiy, Jeremiah Zartman
Decoding how tissue properties emerge across multiple spatial and temporal scales from the integration of local signals is a grand challenge in quantitative biology. For example, the collective behavior of epithelial cells is critical for shaping developing embryos. Understanding how epithelial cells interpret a diverse range of local signals to coordinate tissue-level processes requires a systems-level understanding of development. Integration of multiple signaling pathways that specify cell signaling information requires second messengers such as calcium ions...
April 3, 2018: Physical Biology
https://www.readbyqxmd.com/read/29609928/complementary-and-alternative-medicine-utilisation-for-the-management-of-acute-respiratory-tract-infection-in-children-a-systematic-review
#14
REVIEW
S Lucas, M Leach, S Kumar
INTRODUCTION: As many as one in two children across the globe use complementary and alternative medicine (CAM) to manage a health condition. Despite the high prevalence of use, there is still limited information on the types of CAM used in children, particularly for the management of one of the most common childhood health complaints - acute respiratory tract infection (ARTI). This systematic review was undertaken to address this knowledge gap. METHODS: Eligible studies reporting the use of CAM in children with ARTI were identified using a targeted search of seven electronic databases and the grey literature...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29608503/risk-adjusted-overall-mortality-as-a-quality-measure-in-the-cardiovascular-intensive-care-unit
#15
Michael Goldfarb
Risk-adjusted mortality has been proposed as a quality of care indicator to gauge Cardiovascular Intensive Care Unit (CICU) performance. Mortality is easily measured, readily understandable, and a meaningful outcome for the patient, provider, administrative agencies, and other key stakeholders. Disease-specific risk-adjusted mortality is commonly used in cardiovascular medicine as an indicator of care quality, for external accreditation, and to determine payer reimbursement. However, the evidence base for overall risk-adjusted mortality in the CICU is limited, with most available data coming from the general critical care literature...
March 30, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29606538/the-evolution-of-radiation-therapy-in-treating-cancer
#16
REVIEW
Dorothy Abshire, Matthew K Lang
OBJECTIVES: Describe the significant changes that have occurred to elevate radiation therapy as a significant modality in treating cancer. DATA SOURCES: Peer-reviewed and lay publications. CONCLUSION: Radiation has been used in medicine since its discovery in the 19th century. Since the start of the 20th century, radiation has been increasingly used to diagnose and treat cancer. Although, radiation therapy was often known to destroy healthy tissue in its attempt to kill cancer cells, technological advancements have allowed for precise and accurate therapy, providing a viable option as a cure for individuals diagnosed with cancer...
March 29, 2018: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/29605206/the-100-most-influential-publications-in-asthma-from-1960-to-2017-a-bibliometric-analysis
#17
REVIEW
Yulan Qu, Chen Zhang, Zhenli Hu, Sha Li, Chen Kong, Yunye Ning, Yan Shang, Chong Bai
BACKGROUND: The area of asthma medicine has produced a large volume of important clinical and scientific papers that can be found in those most influential journals. The purpose of our study was to identify the 100 most cited papers in asthma research and to analyze their characteristics. METHODS: We used the Institute for Scientific Information Web of Knowledge Database to identify the most frequently cited articles published from 1960 to December 2017. Original articles and reviews were included in the study...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29603847/inclusion-of-non-english-speaking-patients-in-research-a-single-institution-experience
#18
Rachel Bernier, Erin Halpin, Steven J Staffa, Lindsey Benson, James A DiNardo, Viviane G Nasr
BACKGROUND: Considering the recent increase in medical care provided to patients from foreign countries and the diversity of languages spoken by families living within the United States, it is important to determine whether non-English-speaking patients have access to participate in clinical research from which they may benefit. AIMS: We aimed to determine the number of non-English-speaking patients presenting to Boston Children's Hospital for medical care between 2011 and 2016, the number of clinical research protocols active within the Department of Anesthesiology, Critical Care and Pain Medicine approved to enroll non-English-speaking patients, as well as the number of both non-English- and English-speaking patients approached and enrolled in these studies...
March 30, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29603634/current-status-of-o-heterocycles-a-synthetic-and-medicinal-overview
#19
Pankaj Kumar Singh, Om Silakari
O-heterocycles have been explored since long in the field of medicinal chemistry but they have not yet been given their due significance and are usually shunned out in comparison to N-heterocycles. Designing of bioactive molecules for almost every pathophysiological condition is primarily focused on designing novel N-heterocycles. The basic reasons for this bias are the ease of synthesis and possible mimicking of physiological molecules by N-heterocycles. But considering only this criteria never provides any breakthrough molecule for any disease condition, rather risk of toxicity/side effects are increased with such molecules...
March 30, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29602854/acupuncture-for-constipation-in-patients-with-stroke-protocol-of-a-systematic-review-and-meta-analysis
#20
Jingbo Zhai, Wei Mu, Jinhua Si, Yan Li, Chen Zhao, Hongcai Shang, Huanan Li, Guihua Tian
INTRODUCTION: Constipation is one of the most common complications in patients with stroke. Acupuncture has gained increased popularity for the management of constipation. However, there is a lack of supportive evidence on the efficacy of acupuncture for poststroke constipation. This systematic review aims to collect and critically appraise all the available evidence about the efficacy and safety of the acupuncture for constipation in poststroke patients. METHODS AND ANALYSIS: A comprehensive search of Pubmed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, four Chinese databases (National Knowledge Infrastructure (CNKI), Chinese Biomedical Literatures database (CBM), Wanfang Digital Periodicals (WANFANG) and Chinese Science and Technology Periodicals (VIP) database), one Japanese medical database (National Institute of Informatics, CiNii) and one Korean medical database (Oriental Medicine Advanced Searching Integrated System, OASIS) will be conducted to identify randomised controlled trials of acupuncture for constipation in poststroke patients...
March 30, 2018: BMJ Open
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