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https://www.readbyqxmd.com/read/29053173/the-williams-legacy-a-critical-reappraisal-of-his-nine-predictions-about-the-evolution-of-senescence
#1
Jean-Michel Gaillard, Jean-François Lemaître
Williams' evolutionary theory of senescence based on antagonistic pleiotropy has become a landmark in evolutionary biology, and more recently in biogerontology and evolutionary medicine. In his original article, Williams launched a set of nine 'testable deductions' from his theory. Although some of these predictions have been repeatedly discussed, most have been overlooked and no systematic evaluation of the whole set of Williams' original predictions has been performed. For the sixtieth anniversary of the publication of the Williams' paper, we provide an updated evaluation of all these predictions...
October 20, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29051396/facial-transplantation-an-update-of-results-and-perspectives-from-tissue-engineering
#2
Francesco Simonacci, Roberto Toni, Edoardo Raposio
BACKGROUND/AIM: Facial transplantation is a revolutionary procedure developed recently, which is indicated if autologous transfers fail to restore human appearance. More than 30 patients have undergone facial transplantation in different centers worldwide. Here, we provide an update on its main anatomical, surgical, immunological, ethical, and follow- up aspects. We also provide innovative perspectives of regenerative medicine and tissue engineering that could hold promise for this emerging surgical field...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29047353/precision-medicine-for-all-challenges-and-opportunities-for-a-precision-medicine-approach-to-critical-illness
#3
REVIEW
Christopher W Seymour, Hernando Gomez, Chung-Chou H Chang, Gilles Clermont, John A Kellum, Jason Kennedy, Sachin Yende, Derek C Angus
All of medicine aspires to be precise, where a greater understanding of individual data will lead to personalized treatment and improved outcomes. Prompted by specific examples in oncology, the field of critical care may be tempted to envision that complex, acute syndromes could bend to a similar reductionist philosophy-where single mutations could identify and target our critically ill patients for treatment. However, precision medicine faces many challenges in critical care. These include confusion about terminology, uncertainty about how to divide patients into discrete groups, the challenges of multi-morbidity, scale, and the need for timely interventions...
October 18, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29042287/the-genus-lycium-as-food-and-medicine-a-botanical-ethnobotanical-and-historical-review
#4
REVIEW
Ruyu Yao, Michael Heinrich, Caroline S Weckerle
ETHNOPHARMACOLOGICAL RELEVANCE: Lycium is widely distributed in the arid to semi-arid environments of North and South America, Africa, and Eurasia. In recent years, Lycium barbarum and L. chinense have been advertised as "superfood" with healthy properties. Despite of its popularity, there is a lack of an integrated and critical appraisal of the existing evidence for the use of Lycium. AIM OF THE STUDY: There is a need to understand: 1) Which species were used and how the uses of Lycium developed spatially and over time, 2) how uses differ among regions with different culture backgrounds, and 3) how traditional and current therapeutic and preventive health claims correlate with pharmacological findings...
October 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29040510/genomic-fragmentation-and-extrachromosomal-telomeric-repeats-impact-assessment-of-telomere-length-in-human-spermatozoa-quantitative-experiments-and-systematic-review
#5
P Kurjanowicz, S Moskovtsev, C Librach
STUDY QUESTION: Can differences in DNA isolation alter assessment of sperm telomere length (spTL) and do they account for conflicting results in the literature on spTL and male fertility? SUMMARY ANSWER: DNA isolation methods preferentially include or exclude short, extrachromosomal (EC) telomere-specific sequences that alter spTL measurements, and are responsible for a proportion of the disparity observed between investigations. WHAT IS KNOWN ALREADY: The relationship between spTL and male fertility has become an active area of research...
September 29, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29038791/traditional-chinese-medicine-protects-against-cytokine-production-as-the-potential-immunosuppressive-agents-in-atherosclerosis
#6
REVIEW
Yan Ren, Wei Qiao, Dongliang Fu, Zhiwei Han, Wei Liu, Weijie Ye, Zunjing Liu
Atherosclerosis is a chronic inflammatory disease caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a critical factor at all stages of atherosclerosis progression. Proinflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. Accordingly, strategies to inhibit immune activation and impede immune responses towards anti-inflammatory activity are an alternative therapeutic strategy to conventional chemotherapy on cardiocerebrovascular outcomes...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29036901/importance-of-leadership-style-towards-quality-of-care-measures-in-healthcare-settings-a-systematic-review
#7
REVIEW
Danae F Sfantou, Aggelos Laliotis, Athina E Patelarou, Dimitra Sifaki-Pistolla, Michail Matalliotakis, Evridiki Patelarou
Effective leadership of healthcare professionals is critical for strengthening quality and integration of care. This study aimed to assess whether there exist an association between different leadership styles and healthcare quality measures. The search was performed in the Medline (National Library of Medicine, PubMed interface) and EMBASE databases for the time period 2004-2015. The research question that guided this review was posed as: "Is there any relationship between leadership style in healthcare settings and quality of care?" Eighteen articles were found relevant to our research question...
October 14, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29035744/a-systematic-review-of-instrumental-variable-analyses-using-geographic-region-as-an-instrument
#8
Emily A Vertosick, Melissa Assel, Andrew J Vickers
BACKGROUND: Instrumental variables analysis is a methodology to mitigate the effects of measured and unmeasured confounding in observational studies of treatment effects. Geographic area is increasingly used as an instrument. METHODS: We conducted a literature review to determine the properties of geographic area in studies of cancer treatments. We identified cancer studies performed in the United States which incorporated instrumental variable analysis with area-wide treatment rate within a geographic region as the instrument...
October 13, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29035404/-biological-significance-of-chromium-iii-for-the-human-organism
#9
REVIEW
Anna Piotrowska, Wanda Pilch, Łukasz Tota, Gabriel Nowak
Currently, chromium is probably the most controversial transition metal. In recent publications it is clearly stated that it is not an essential micronutrient and should be considered to have a pharmacological effect. Conflicting scientific reports along with a huge amount of dietary supplements, as well as dietary and sports nutrients available on the market have prompted the authors to investigate the available information on the range of possible application, efficacy and safety of products containing salts or chelates of chromium III...
October 12, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/29035308/gut-microbiota-and-nonalcoholic-fatty-liver-disease-insights-on-mechanisms-and-therapy
#10
REVIEW
Junli Ma, Qihang Zhou, Houkai Li
The gut microbiota plays critical roles in development of obese-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes(T2D), and insulin resistance(IR), highlighting the potential of gut microbiota-targeted therapies in these diseases. There are various ways that gut microbiota can be manipulated, including through use of probiotics, prebiotics, synbiotics, antibiotics, and some active components from herbal medicines. In this review, we review the main roles of gut microbiota in mediating the development of NAFLD, and the advances in gut microbiota-targeted therapies for NAFLD in both the experimental and clinical studies, as well as the conclusions on the prospect of gut microbiota-targeted therapies in the future...
October 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29032331/unraveling-the-mechanistic-effects-of-electric-field-stimulation-towards-directing-stem-cell-fate-and-function-a-tissue-engineering-perspective
#11
REVIEW
Greeshma Thrivikraman, Sunil Kumar Boda, Bikramjit Basu
Electric field (EF) stimulation can play a vital role in eliciting appropriate stem cell response. Such an approach is recently being established to guide stem cell differentiation through osteogenesis/neurogenesis/cardiomyogenesis. Despite significant recent efforts, the biophysical mechanisms by which stem cells sense, interpret and transform electrical cues into biochemical and biological signals still remain unclear. The present review critically analyses the variety of EF stimulation approaches that can be employed to evoke appropriate stem cell response and also makes an attempt to summarize the underlying concepts of this notion, placing special emphasis on stem cell based tissue engineering and regenerative medicine...
October 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/29031132/effectiveness-of-policy-changes-to-reduce-harm-from-unrecorded-alcohol-in-russia-between-2005-and-now
#12
Maria Neufeld, Jürgen Rehm
BACKGROUND: Consumption of unrecorded alcohol (alcohol that is not taxed and reflected in official statistics, but consumed as a beverage) has been identified as one of the main contributors to alcohol-attributable premature mortality in Russia. The problem was highlighted by a recent a mass poisoning with surrogate alcohol occurred in the Siberian city of Irkutsk. METHODS: Based on key publications and legislative documents, a narrative review was undertaken about alcohol-related harm reduction policies in Russia for the period between 2005 and 2017, as well as the impact of these policies on the recorded and unrecorded alcohol consumption and alcohol market...
October 11, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29030249/sex-as-a-biological-variable-drug-use-and-abuse
#13
Anthony L Riley, Briana J Hempel, Matthew M Clasen
The study of sex as a biological variable is a necessary emphasis across a wide array of endpoints, including basic neuroscience, medicine, mental health, physiology and behavior. The present review summarizes work from clinical and preclinical populations on sex differences in drug use and abuse, ranging from initiation to escalation/dysregulation and from drug cessation/abstinence to relapse. These differences are analyzed in the context of the addiction cycle conceptualization of Koob and his colleagues and address patterns of drug use (binge/intoxication), motivation underlying its use (withdrawal/negative affect) and likelihood and causes of craving and relapse of drug taking (anticipation/preoccupation)...
October 10, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29029586/use-and-misuse-of-opioids-in-chronic-pain
#14
Nora Volkow, Helene Benveniste, A Thomas McLellan
The prescribing of opioid analgesics for pain management-particularly for management of chronic noncancer pain (CNCP)-has increased more than fourfold in the United States since the mid-1990s. Yet there is mounting evidence that opioids have only limited effectiveness in the management of CNCP, and the increased availability of prescribed opioids has contributed to upsurges in opioid-related addiction cases and overdose deaths. These concerns have led to critical revisiting and modification of prior pain management practices (e...
October 13, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/29029541/cancer-and-the-kidney-dangereoux-liasons-or-price-paid-for-the-progress-in-medicine
#15
REVIEW
Jolanta Małyszko, Leszek Kozlowski, Klaudia Kozłowska, Maciej Małyszko, Jacek Małyszko
A long time ago, the links between renal disease and malignancy were observed, however, quite recently, their importance was recognized and 'new' subspecialty in nephrology, namely 'onconephrology' was established. In the XXI century, patients with malignancy make up the most growing number of the subjects seen for nephrology consult and/or critical care nephrology services. A plethora of renal problems may be found in patients with malignancy. They may influence not only their short-term outcomes but also the adequate therapy of the underlying oncological problem...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028071/how-to-isolate-a-ready-to-use-adipose-derived-stem-cells-pellet-for-clinical-application
#16
E Raposio, N Bertozzi
Adipose-derived stem cells (ASCs) are multipotent mesenchymal stem cells (MSCs) that show definitive stem cell characteristics such as plastic adherence in culture, ability to maintain multipotency upon in vitro expansion, and self-renewal capacity. ASCs are particularly promising for use in regenerative medicine because they can be harvested easily from adipose tissue by standard liposuction, with minimal donor site morbidity. Since ASCs do not necessitate ex vivo expansion to obtain clinically significant cell numbers, it is critical to identify a standardized method that maximizes the number of ASCs collected...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027412/-research-advances-in-secondary-development-of-chinese-patent-medicines-based-on-quality-by-design-concept
#17
Xing-Chu Gong, Teng Chen, Hai-Bin Qu
Quality by design (QbD) concept is an advanced pharmaceutical quality control concept. The application of QbD concept in the research and development of pharmaceutical processes of traditional Chinese medicines (TCM) mainly contains five parts, including the definition of critical processes and their evaluation criteria, the determination of critical process parameters and critical material attributes, the establishment of quantitative models, the development of design space, as well as the application and continuous improvement of control strategy...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29026930/-burnout-a%C3%A2-call-for-action
#18
REVIEW
C S Hartog
BACKGROUND: Burnout is an emerging topic and has recently been the subject of a position paper of the US American Society of Critical Care Medicine. OBJECTIVES: To give an overview over prevalence, causes, and relevance of burnout in intensive care unit (ICU) clinicians and point to potential prevention strategies MATERIALS AND METHODS: Narrative review. RESULTS AND CONCLUSION: Burnout is a job-related state which results from long-lasting, permanent work overload when short spells of recreation, for instance during the weekend, are not effective to reduce exhaustion, vegetative symptoms, loss of efficiency, and depersonalization...
October 12, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29025377/18f-fdg-pet-ct-in-breast-cancer-evidence-based-recommendations-in-initial-staging
#19
REVIEW
Ana Paula Caresia Aroztegui, Ana María García Vicente, Soledad Alvarez Ruiz, Roberto Carlos Delgado Bolton, Javier Orcajo Rincon, Jose Ramon Garcia Garzon, Maria de Arcocha Torres, Maria Jose Garcia-Velloso
Current guidelines do not systematically recommend 18F-FDG PET/CT for breast cancer staging; and the recommendations and level of evidence supporting its use in different groups of patients vary among guidelines. This review summarizes the evidence about the role of 18F-FDG PET/CT in breast cancer staging and the therapeutic and prognostic impact accumulated in the last decade. Other related aspects, such as the association of metabolic information with biology and prognosis are considered and evidence-based recommendations for the use of 18F-FDG PET/CT in breast cancer staging are offered...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29025360/best-practice-of-identification-and-proteomic-analysis-of-extracellular-vesicles-in-human-health-and-disease
#20
Barbara W Sódar, Árpád Kovács, Tamás Visnovitz, Éva Pállinger, Károly Vékey, Gabriella Pocsfalvi, Lilla Turiák, Edit I Buzás
Extracellular vesicles are emerging sources of biomarkers for modern preventive and precision medicine. Extracellular vesicles in body fluids offer a unique opportunity for integrative biomarker approaches due to their complex biocargo that includes proteins, lipids, nucleic acids and metabolites. Mass spectrometry-based proteomics data suggest that a significant portion of human proteins are sorted into extracellular vesicles and amenable for biomarker discovery schemes. Areas covered: this review focuses on key aspects of isolation, quality control and subsequent analysis of blood plasma- and conditioned medium-derived extracellular vesicle proteins, and summarizes the current state-of-the-art in the field...
October 13, 2017: Expert Review of Proteomics
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