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Maya Gopalakrishnan

Francesca Petralia, Vasily N Aushev, Kalpana Gopalakrishnan, Maya Kappil, Nyan W Khin, Jia Chen, Susan L Teitelbaum, Pei Wang
Motivation: Integrative approaches characterizing the interactions among different types of biological molecules have been demonstrated to be useful for revealing informative biological mechanisms. One such example is the interaction between microRNA (miRNA) and messenger RNA (mRNA), whose deregulation may be sensitive to environmental insult leading to altered phenotypes. The goal of this work is to develop an effective data integration method to characterize deregulation between miRNA and mRNA due to environmental toxicant exposures...
July 15, 2017: Bioinformatics
Luz Angela Torres-de la Roche, Rajesh Devassy, Sreelatha Gopalakrishnan, Maya Sophie de Wilde, Anja Herrmann, Angelika Larbig, Rudy Leon De Wilde
Vaginal agenesis is a congenital anomaly that affects the life of one of each four thousand women around the world. There is a trend that patients request immediate surgical correction, instead of passive vaginal dilatation. Therefore a differentiated counselling should be provided. We present a comparative chart, based on published evidence, with aspect to the available techniques, which will facilitate the decision-making process in the clinical practice. From our point of view, the best results are achieved with techniques that combine the advantages of the minimal-invasive surgery with those derived of the use of peritoneum as covering tissue of the neovagina...
2016: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
Maya Gopalakrishnan, Suman Saurabh
Remote ischaemic preconditioning is emerging as a promising clinical technique which can afford immediate protection against coronary ischaemia. The mechanisms which mediate the signal transduction from remote organ to the heart are still unclear. The role of ATP sensitive potassium channels in ischaemic preconditioning has been established. It is known that the red blood cell (RBC) acts as a mediator of local autoregulation in adjusting oxygen supply to demand by sensing hypoxia and releasing ATP locally to achieve vasodilatation in the adjacent vascular beds...
December 2014: Medical Hypotheses
S Deepak Amalnath, Maya Gopalakrishnan, Tarun Kumar Dutta
Split-hand/foot malformation (SHFM) is a rare condition which can be either syndromic or nonsyndromic. We report three unrelated pedigrees, one with autosomal dominant (AD) inheritance and the other two with autosomal recessive (AR) pattern. We also briefly review the published reports from India.
January 2014: Indian Journal of Human Genetics
K V Vinod, Keerthi Talari, Maya Gopalakrishnan, K K Nisar, T K Dutta
No abstract text is available yet for this article.
March 2012: Journal of Vector Borne Diseases
Madanmohan, Sivasubramaniyan K Mahadevan, Selvakumar Balakrishnan, Maya Gopalakrishnan, E S Prakash
The present study was designed to test whether yoga training of six weeks duration modulates sweating response to dynamic exercise and improves respiratory pressures, handgrip strength and handgrip endurance. Out of 46 healthy subjects (30 males and 16 females, aged 17-20 yr), 23 motivated subjects (15 male and 8 female) were given yoga training and the remaining 23 subjects served as controls. Weight loss following Harvard step test (an index of sweat loss), maximum inspiratory pressure, maximum expiratory pressure, 40 mm endurance, handgrip strength and handgrip endurance were determined before and after the six week study period...
April 2008: Indian Journal of Physiology and Pharmacology
Selvakumar Balakrishnan, Maya Gopalakrishnan, Murali Alagesan, E Sankaranarayanan Prakash
It is common to see chapters on acid-base physiology state that the goal of acid-base regulatory mechanisms is to maintain the pH of arterial plasma and not arterial Pco(2) (Pa(CO(2))) or plasma HCO(3). A hypothetical situation in which the Pa(CO(2)) of arterial plasma is 80 mmHg and the plasma HCO(3) concentration is 48 mM is presented and analyzed to get over this misconception. As per the modified Henderson equation, the pH of arterial plasma would be 7.4; however, we explain that this may be associated with intracellular acidosis due to intracellular hypercapnia and that derangement of homeostasis is evident from the occurrence of respiratory depression and, eventually, coma in the patient described...
March 2007: Advances in Physiology Education
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