keyword
https://read.qxmd.com/read/38510341/toward-next-generation-endoscopes-integrating-biomimetic-video-systems-nonlinear-optical-microscopy-and-deep-learning
#1
REVIEW
Stefan G Stanciu, Karsten König, Young Min Song, Lior Wolf, Costas A Charitidis, Paolo Bianchini, Martin Goetz
According to the World Health Organization, the proportion of the world's population over 60 years will approximately double by 2050. This progressive increase in the elderly population will lead to a dramatic growth of age-related diseases, resulting in tremendous pressure on the sustainability of healthcare systems globally. In this context, finding more efficient ways to address cancers, a set of diseases whose incidence is correlated with age, is of utmost importance. Prevention of cancers to decrease morbidity relies on the identification of precursor lesions before the onset of the disease, or at least diagnosis at an early stage...
June 2023: Biophysics reviews
https://read.qxmd.com/read/38505912/a-systems-biology-approach-unveils-a-critical-role-of-dpp4-in-upper-gastrointestinal-cancer-patient-outcomes
#2
JOURNAL ARTICLE
Sudhir Kotnala, Anupam Dhasmana, Swati Dhasmana, Shafiul Haque, Murali M Yallapu, Manish K Tripathi, Meena Jaggi, Subhash C Chauhan
Gastrointestinal (GI) cancers comprise of cancers that affect the digestive system and its accessory organs. The late detection and poor prognosis of GI cancer emphasizes the importance of identifying reliable and precise biomarkers for early diagnosis and prediction of prognosis. The membrane-bound glycoprotein dipeptidyl-peptidase 4 (DPP4), also known as CD26, is ubiquitously expressed and has a wide spectrum of biological roles. The role of DPP4/CD26 in tumor progression in different types of cancers remains elusive...
2024: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/38500905/comprehensive-review-on-pancreatic-head-cancer-pathogenesis-diagnosis-and-treatment-challenges-in-the-quest-for-improved-survival
#3
REVIEW
Shreya Singh, Anupama Sawal
This comprehensive review explores the complexities surrounding pancreatic head cancer, a highly fatal and challenging-to-treat illness with a survival rate of less than five years. Despite being a major contributor to cancer-related deaths, pancreatic head malignancy often eludes early detection due to its posterior location and high metastatic potential. The review delves into the associated symptoms, including gastric outlet obstruction and obstructive jaundice, highlighting the impact on the patient's eligibility for surgery...
February 2024: Curēus
https://read.qxmd.com/read/38500767/case-report-cutaneous-metastases-as-a-first-manifestation-from-breast-cancer-with-concurrent-gastric-metastases
#4
Lulu Xu, Congcong Wang, Xiaoling Yang, Liangliang Dong
Background: Breast cancer represents a leading cause of malignancy among Chinese women, posing a significant health burden. The diagnosis of metastatic breast cancer, particularly to uncommon sites like the skin and stomach, presents distinct challenges. Case introduction: This case report describes a 71-year-old Chinese women with a persistent back rash lasting more than 6 months. Physical examination revealed red papules on her back. Immunohistochemistry confirmed positive for cytokeratin 7(CK7), GATA-3 and GCDFP15, as well as negative staining of cytokeratin 20 (CK20), suggesting breast cancer metastasis...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38494808/-the-second-web-questionnaire-survey-on-cancer-cachexia-japanese-evidence-for-patients-of-cancer-cachexia-%C3%A2-j-epocc-%C3%A2-disease-awareness-and-issues-related-to-cancer-cachexia-among-healthcare-professionals
#5
JOURNAL ARTICLE
Maimi Kiguchi, Satomi Kanemata, Koji Machii, Issei Doi, Futoshi Kinoshita
In 2019, the Cancer Cachexia Web Questionnaire Survey(J-EPOCC)was conducted among cancer patients, their families and healthcare professionals in Japan, and it showed that the term"cancer cachexia"was highly recognized among health care professionals, whereas the staging and criteria for cancer cachexia defined by European Palliative Care Research Collaborative( EPCRC)was less understood. Also, many healthcare professionals tended to consider the term"cancer cachexia" as the terminal stage of cancer, and most of them lacked the knowledge that cancer cachexia is a disease complication which is potentially developed from the early stage of cancer...
March 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38491808/novel-metabolic-biomarker-for-early-detection-and-diagnosis-to-the-patients-with-gastric-cardia-adenocarcinoma
#6
JOURNAL ARTICLE
Meng Xia Wei, Zheng Yang, Pan Pan Wang, Xue Ke Zhao, Xin Song, Rui Hua Xu, Jing Feng Hu, Kan Zhong, Ling Ling Lei, Wen Li Han, Miao Miao Yang, Fu You Zhou, Xue Na Han, Zong Min Fan, Jia Li, Ran Wang, Bei Li, Li Dong Wang
BACKGROUND: Gastric cardia adenocarcinoma (GCA) is classified as Siewert type II adenocarcinoma at the esophagogastric junction in Western countries. The majority of GCA patients do not exhibit early warning symptoms, leading to over 90% of diagnoses at an advanced stage, resulting in a grim prognosis, with less than a 20% 5-year survival rate. METHOD: Metabolic features of 276 GCA and 588 healthy controls were characterized through a widely-targeted metabolomics by UPLC-MS/MS analysis...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491214/early-detection-of-anthracycline-induced-cardiotoxicity-using-68-%C3%A2-ga-ga-fapi-04-imaging
#7
JOURNAL ARTICLE
Zhuxin Wei, Hongchuang Xu, Bixi Chen, Jiaxin Wang, Xing Yang, Min-Fu Yang, Shihua Zhao
PURPOSE: Anthracycline-induced cardiotoxicity (AIC), whose major manifestation is diffuse myocardial fibrosis, is an important clinical problem in cancer therapy. Therefore, early identification and treatment are clinically important. This study aims to explore the feasibility of using 68  Ga-labelled fibroblast activation protein (FAP) inhibitor ([68  Ga]Ga-FAPI) positron emission tomography/computed tomography (PET/CT) for the early identification of the fibrotic process and guidance of antifibrosis therapy in AIC...
March 16, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38482223/two-autopsied-gastric-cancer-cases-of-rare-drug-induced-pneumonia-associated-with-nivolumab-plus-s-1-and-oxaliplatin-a-case-report
#8
Taku Noumi, Shoka Kimura, Takuro Fushimi, Shuichi Sakamoto, Kayo Nakamura, Soichiro Fushimi, Toshiaki Ohara, Shuko Mashimo, Hiroyuki Tao, Takanori Watanabe, Daizo Kishino
BACKGROUND: Drug-induced pneumonia, especially immune-related adverse events, can sometimes be fatal, and it is crucial to seize the signs for early treatment. A clinical trial (ATTRACTION-4) reported no cases of grade 4 or 5 pneumonia or interstitial lung disease associated with nivolumab plus S-1 and oxaliplatin. However, we encountered two cases of fatal pneumonia induced by this regimen. CASE DESCRIPTION: The two patients were in their 70s, male and diagnosed gastric cancer with peritoneal dissemination...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38481775/demographics-distance-to-gastrointestinal-specialists-and-social-deprivation-are-associated-with-advanced-stage-of-gastrointestinal-cancer-diagnosis
#9
JOURNAL ARTICLE
Shria Kumar, Saltenat Moghaddam, Darius E Chyou, Ibrahim Soumare, Daniel A Sussman
BACKGROUND: Gastrointestinal (GI) luminal cancers can be detected at early stages by endoscopic procedures. Place-based factors, such as social deprivation and distance to specialist care, are under-investigated with regard to the stage of diagnosis. METHODS: This was a retrospective cohort study among persons ≥18 years of age in the Florida Cancer Data System, a population-based cancer incidence registry. We included persons diagnosed with esophageal cancer, gastric canceror colorectal cancer, with at least 1 measure of geographic location during the period January 1, 1981, to December 31, 2016...
2024: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://read.qxmd.com/read/38478628/genome-wide-repeat-landscapes-in-cancer-and-cell-free-dna
#10
JOURNAL ARTICLE
Akshaya V Annapragada, Noushin Niknafs, James R White, Daniel C Bruhm, Christopher Cherry, Jamie E Medina, Vilmos Adleff, Carolyn Hruban, Dimitrios Mathios, Zachariah H Foda, Jillian Phallen, Robert B Scharpf, Victor E Velculescu
Genetic changes in repetitive sequences are a hallmark of cancer and other diseases, but characterizing these has been challenging using standard sequencing approaches. We developed a de novo kmer finding approach, called ARTEMIS (Analysis of RepeaT EleMents in dISease), to identify repeat elements from whole-genome sequencing. Using this method, we analyzed 1.2 billion kmers in 2837 tissue and plasma samples from 1975 patients, including those with lung, breast, colorectal, ovarian, liver, gastric, head and neck, bladder, cervical, thyroid, or prostate cancer...
March 13, 2024: Science Translational Medicine
https://read.qxmd.com/read/38473395/advanced-diagnostic-and-therapeutic-endoscopy-for-early-gastric-cancer
#11
REVIEW
Mitsuhiro Fujishiro
Endoscopy is mandatory to detect early gastric cancer (EGC). When considering the cost-effectiveness of the endoscopic screening of EGC, risk stratification by combining serum pepsinogen values and anti- H. pylori IgG antibody values is very promising. After the detection of suspicious lesions of EGC, a detailed observation using magnifying endoscopy with band-limited light is necessary, which reveals an irregular microsurface and/or an irregular microvascular pattern with demarcation lines in the case of cancerous lesions...
March 3, 2024: Cancers
https://read.qxmd.com/read/38473010/feasibility-and-efficacy-of-gastric-underwater-endoscopic-mucosal-resection
#12
JOURNAL ARTICLE
Dong Hyun Kim, Seon Young Park, Jin Won Kim, Hyun Soo Kim
Gastric cancer, a leading cause of cancer-related deaths globally, necessitates effective and early detection and treatment strategies. Endoscopic resection techniques, particularly endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), have evolved significantly, enhancing the treatment of gastric neoplasms. Underwater endoscopic mucosal resection (UEMR) is a widely used technique for the resection of duodenal and colorectal neoplasms. However, the feasibility and efficacy of UEMR in the stomach are not well established...
March 3, 2024: Diagnostics
https://read.qxmd.com/read/38471421/research-progress-of-human-key-dna-and-rna-methylation-related-enzymes-assay
#13
REVIEW
Tiantian Ma, Qiongwen Zhang, Shuying Zhang, Dan Yue, Fanting Wang, Yujie Ren, Hengmiao Zhang, Yinuo Wang, Yongjun Wu, Li-E Liu, Fei Yu
Gene methylation-related enzymes (GMREs) are disfunction and aberrantly expressed in a variety of cancers, such as lung, gastric, and pancreatic cancers and have important implications for human health. Therefore,it is critical for early diagnosis and therapy of tumor to develop strategies that allow rapid and sensitive quantitative and qualitative detection of GMREs. With the development of modern analytical techniques and the application of various biosensors, there are numerous methods have been developed for analysis of GMREs...
March 5, 2024: Talanta
https://read.qxmd.com/read/38455396/cell-free-dna-methylation-profiles-enable-early-detection-of-colorectal-and-gastric-cancer
#14
JOURNAL ARTICLE
Xiaotian Lei, Dongxun Zhou, Ying Wen, Weihong Sha, Juan Ma, Xixiang Tu, Kewei Zhai, Caixia Li, Hong Wang, Jinsheng Tao, Zhiwei Chen, Weimei Ruan, Jian-Bing Fan, Bin Wang, Chunhui Cui
Colorectal cancer (CRC) and gastric cancer (GC) rank the top five common and lethal cancers worldwide. Early detection can significantly reduce the mortality of CRC and GC. However, current clinical screening methods including invasive endoscopic techniques and noninvasive fecal occult blood test screening tests/fecal immunochemical test have shown low sensitivity or unsatisfactory patient's compliance. Aberrant DNA methylation occurs frequently in tumorigenesis and cell-free DNA (cfDNA) methylation has shown the potential in multi-cancer detection...
2024: American Journal of Cancer Research
https://read.qxmd.com/read/38449402/-the-second-web-questionnaire-survey-on-cancer-cachexia-japanese-evidence-for-patients-of-cancer-cachexia%C3%A2-j-epocc%C3%A2-challenges-in-early-detection-and-early-intervention-for-appetite-loss-and-weight-loss-during-cancer-treatment
#15
JOURNAL ARTICLE
Maimi Kiguchi, Satomi Kanemata, Koji Machii, Issei Doi, Futoshi Kinoshita
In 2019, the Cancer Cachexia Web Questionnaire Survey(J-EPOCC), conducted among cancer patients, their families and healthcare professionals in Japan showed that nearly half of patients who had experienced appetite loss or weight loss during cancer treatment had not consulted with healthcare professionals about their symptoms, and it meant that patients missed the opportunity to receive medical intervention. Since anamorelin was approved in 2021 fo"r Cancer cachexia in non- small cell lung cancer, gastric cancer, pancreatic cancer and colorectal cancer", the treatment environment for cancer cachexia has greatly changed...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38448623/impact-of-endoscopic-surveillance-on-the-early-diagnosis-and-endoscopic-resection-likelihood-of-gastric-cancer
#16
JOURNAL ARTICLE
Lu Sun, Yanjie Shen, Liang Huang, Jing Zhao, Meng Li, Yue Hu, Bin Lyu
BACKGROUND: Endoscopy could help detect early gastric cancer (EGC) and improve the prognosis of patients. The aim of this study was to analyze the impact of endoscopy and endoscopic surveillance on the early detection of gastric cancer (GC), GC staging, and treatment selection. METHODS: Patients with GC diagnosed at our center from 2010 to 2022 were retrospectively analyzed and allocated to the short-interval group (had received endoscopy within 3 years before diagnosis), the long-interval group (had received endoscopy more than 3 years before diagnosis), and the unchecked group (had not received endoscopy before diagnosis)...
March 6, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38445116/a-case-report-of-the-coexistence-of-gastric-cancer-with-polycystic-kidney-and-liver-disease-unveiling-the-complexity
#17
Amit Girme, Vernika Gupta
Polycystic kidney disease (PKD) is a genetic disorder that comprises multiple cystic lesions in the kidneys. The association of PKD with gastric cancer has been studied. We present a rare presentation of stomach cancer with polycystic liver and kidney disease. A male patient in his 40s presented with epigastric pain, nausea, retrosternal burning, and occasional episodes of vomiting. Esophagogastroduodenoscopy revealed ulceroproliferative growth in the prepyloric region. Biopsies revealed moderately differentiated adenocarcinoma which was confirmed by contrast-enhanced computed tomography of the abdomen and pelvis...
February 2024: Curēus
https://read.qxmd.com/read/38444883/population-level-cancer-screening-and-cancer-care-in-bhutan-2020-2023-a-review
#18
REVIEW
Thinley Dorji, Sangay Wangmo, Sonam Dargay, Namkha Dorji, Yeshey Dorjey, Birendra Pradhan, Dechen Pema, Choney Dema, Jamyang Choden, Tandin Dorji, Mimi Lhamu Mynak, Pempa, Kinga Jamphel
Screening of cancers is an important intervention in reducing the incidence and mortality related to cancers. Bhutan is one small country that is witnessing an increasing incidence and mortality related to cancers. The government implemented a time-bound population-level screening for gastric, cervical and breast cancers from 2020 to 2023 with an overall coverage of 91.2% of the eligible population. Among 370,225 individuals screened for H pylori , 32.4% tested positive; among 53,182 who underwent upper gastrointestinal endoscopy and biopsy, 255 (0...
May 2024: Lancet Reg Health Southeast Asia
https://read.qxmd.com/read/38440419/predictive-factors-associated-with-survival-in-female-gastric-cancer-patients-in-southeast-asia
#19
JOURNAL ARTICLE
Phubordee Bongkotvirawan, Natsuda Aumpan, Bubpha Pornthisarn, Soonthorn Chonprasertsuk, Sith Siramolpiwat, Patommatat Bhanthumkomol, Pongjarat Nunanun, Navapan Issariyakulkarn, Varocha Mahachai, Kammal Kumar Pawa, Ratha-Korn Vilaichone
INTRODUCTION: Association of Southeast Asian Nations (ASEAN) countries have high Helicobacter pylori infections, and gastric cancer (GC) is a leading fatal cancer in this region, especially in female patients. This study aimed to compare clinical manifestations, histopathological subtypes, and prognostic factors associated with the overall survival rate of female GC patients in this important region. METHODS: This retrospective cohort study was conducted between 2007 and 2022 at a tertiary care center in Thailand...
2024: Women's health reports
https://read.qxmd.com/read/38436760/racial-disparities-of-gastric-cancer-in-the-usa-an-overview-of-epidemiology-global-screening-guidelines-and-targeted-screening-in-a-heterogeneous-population
#20
REVIEW
Jean Woo Mok, Yeong Ha Oh, Deepa Magge, Sekhar Padmanabhan
Gastric cancer is the fifth most common cancer diagnosis and fourth leading cause of cancer-related death globally. The incidence of gastric cancer in the USA shows significant racial and ethnic disparities with gastric cancer incidence in Korean Americans being over five times higher than in non-Hispanic whites. Since gastric cancer is not common in the USA, there are no current screening guidelines. In countries with higher incidences of gastric cancer, screening guidelines have been implemented for early detection and intervention and this has been associated with a reduction in mortality...
March 4, 2024: Gastric Cancer
keyword
keyword
118942
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.