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Early gastric cancer detection

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https://www.readbyqxmd.com/read/29141593/bidirectional-alteration-of-cav-1-expression-is-associated-with-mitogenic-conversion-of-its-function-in-gastric-tumor-progression
#1
Byung-Kyu Ryu, Min-Goo Lee, Nam-Hoon Kim, Kil Yeon Lee, Shin-Ju Oh, Jung-Rock Moon, Hyo Jong Kim, Sung-Gil Chi
BACKGROUND: Expression of caveolin-1 (Cav-1) is frequently altered in many human cancers and both tumor suppression and promotion functions of Cav-1 have been suggested based on its expression status. However, it remains unanswered how Cav-1 provokes opposite effects in different cancers or different phases of tumor progression. METHODS: To explore the implication of Cav-1 alteration in gastric tumorigenesis, the expression and mutational status of Cav-1 and its effects on tumor cell growth were characterized...
November 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29137412/long-non-coding-rna-snhg15-inhibits-p15-and-klf2-expression-to-promote-pancreatic-cancer-proliferation-through-ezh2-mediated-h3k27me3
#2
Zhonghua Ma, Hesuyuan Huang, Jirong Wang, Yan Zhou, Fuxing Pu, Qinghong Zhao, Peng Peng, Bingqing Hui, Hao Ji, Keming Wang
Long non-coding RNA (lncRNA) is emerging as an critical regulator in multiple cancers, including pancreatic cancer (PC). Recently, lncRNA SNHG15 was found to be up-regulated in gastric cancer and hepatocellular carcinoma, exerting oncogenic effects. Nevertheless, the biological function and regulatory mechanism of SNHG15 remain unclear in pancreatic cancer (PC). In this study, we reported that SNHG15 expression was also upregulated in PC tissues, and its overexpression was remarkably associated with tumor size, tumor node metastasis (TNM) stage and lymph node metastasis in patients with PC...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135096/silibinin-promotes-the-apoptosis-of-gastric-cancer-bgc823-cells-through-caspase-pathway
#3
Runfang Li, Jianmin Yu, Chengjun Wang
PURPOSE: To investigate the effects of silibinin, a natural compound, on the proliferation and apoptosis of BGC-823 gastric cancer cell line and to figure out the relevant pathways. METHODS: BGC-823 gastric cancer cells were treated with silibinin at various concentrations (0,25,50,100,150 and 200μM). Zero μM was the control group and the other concentrations were defined as the experimental groups. The effects of silibinin on the proliferation of BGC-823 gastric cancer cells were explored through methylthiazolyldiphenyltetrazolium bromide (MTT)...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29130221/-development-and-progress-of-diagnosis-and-treatment-for-gastric-cancer-in-china-what-inspiration-we-gained-from-japan-and-korea
#4
Enhao Zhao, Hui Cao
The incidence of gastric cancer in East Asia is highest in the world. Level of screening and inspection in high risk population, diagnosis and treatment in early stage, standardized surgery, minimally invasive techniques and clinical research always reach the international lead. In the past few years, the surgeons and researchers from China have already made considerable progress by learning the experience from Japan and Korea. The early detection of gastric cancer increases annually, the minimally invasive surgeries including endoscopic or laparoscopic operations are widely used, the standard surgical procedure and lymphadenectomy are popularized, meanwhile the clinical research for gastric cancer has also started...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29110039/-endoscopic-and-surgical-treatment-of-early-gastric-and-esophageal-carcinoma
#5
REVIEW
T Haist, M Knabe, A May, D Lorenz
BACKGROUND: The treatment of early gastric (EGC) and esophageal carcinomas (EEC) is an interdisciplinary challenge. The risk of lymph node metastasis (LNM) is the crucial point in choosing the correct treatment option. OBJECTIVE: This article gives an overview of the current treatment options and provides help in choosing the correct therapy. METHOD: Current concepts and therapy algorithms are presented on the basis of a literature review and data from our own center...
November 6, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29109763/survivin-and-xiap-expression-in-distinct-tumor-compartments-of-surgically-resected-gastric-cancer-xiap-as-a-prognostic-marker-in-diffuse-and-mixed-type-adenocarcinomas
#6
Levent Dizdar, Monika Tomczak, Thomas A Werner, Sami A Safi, Jasmin C Riemer, Pablo E Verde, Nikolas H Stoecklein, Wolfram T Knoefel, Andreas Krieg
There is considerable evidence that the inhibitor of apoptosis protein (IAP) family serves a role in tumorigenesis. The most studied IAP family members, survivin and X-linked inhibitor of apoptosis (XIAP), have been demonstrated to serve as biomarkers in distinct tumor entities. Thus, the present study aimed to investigate the expression levels of both IAPs in the tumor center, invasion front and lymph node metastases of surgically resected gastric cancer (GC) specimens. Tissue microarrays containing samples from 201 primary GCs were analyzed...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29094049/diagnostic-predictive-prognostic-and-therapeutic-molecular-biomarkers-in-third-millennium-a-breakthrough-in-gastric-cancer
#7
REVIEW
Nicola Carlomagno, Paola Incollingo, Vincenzo Tammaro, Gaia Peluso, Niccolò Rupealta, Gaetano Chiacchio, Maria Laura Sandoval Sotelo, Gianluca Minieri, Antonio Pisani, Eleonora Riccio, Massimo Sabbatini, Umberto Marcello Bracale, Armando Calogero, Concetta Anna Dodaro, Michele Santangelo
Introduction: Gastric cancer is the fifth most common cancer and the third cause of cancer death. The clinical outcomes of the patients are still not encouraging with a low rate of 5 years' survival. Often the disease is diagnosed at advanced stages and this obviously negatively affects patients outcomes. A deep understanding of molecular basis of gastric cancer can lead to the identification of diagnostic, predictive, prognostic, and therapeutic biomarkers. Main Body: This paper aims to give a global view on the molecular classification and mechanisms involved in the development of the tumour and on the biomarkers for gastric cancer...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29084052/personalizing-gastric-cancer-screening-with-predictive-modeling-of-disease-progression-biomarkers
#8
Rachel Walker, Jaime Mejia, Jae K Lee, Jose M Pimiento, Mokenge Malafa, Anna R Giuliano, Domenico Coppola, Heiko Enderling
Gastric cancer (GC) remains the third most common cause of cancer-related death worldwide. Infection with Helicobacter pylori is responsible for over 70% of GC incidence; colonization induces chronic inflammation, which can facilitate progression to intestinal metaplasia, dysplasia, and GC (Correa pathway). Although H. pylori eradication is a necessary first step in GC prevention, some patients continue to progress to advanced stage disease if substantial tissue damage has occurred or inflammation persists...
October 27, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29081696/implication-of-gastric-cancer-molecular-genetic-markers-in-surgical-practice
#9
REVIEW
Marina V Nemtsova, Vladimir V Strelnikov, Alexander S Tanas, Igor I Bykov, Dmitry V Zaletaev, Viktoria V Rudenko, Alexander I Glukhov, Tatiana V Kchorobrich, Yi Li, Vadim V Tarasov, George E Barreto, Gjumrakch Aliev
INTRODUCTION: We have investigated aberrant methylation of genes CDH1, RASSF1A, MLH1, N33, DAPK, expression of genes hTERT, MMP7, MMP9, BIRC5 (survivin), PTGS2, and activity of telomerase of 106 gastric tumor samples obtained intra-operatively and 53 gastric tumor samples from the same group of patients obtained endoscopically before surgery. Biopsy specimens obtained from 50 patients with chronic calculous cholecystitis were used as a control group. Together with tissue samples obtained from different sites remote to tumors, a total of 727 samples have been studied...
October 2017: Current Genomics
https://www.readbyqxmd.com/read/29072067/stage-association-of-preoperative-serum-carcinoembryonic-antigen-with-gastric-adenocarcinoma-in-iranian-patients
#10
Afshin Shafaghi, Fariborz Mansour- Ghanaei, Farahnaz Joukar, Farhad Nabavi, Alireza Mansour- Ghanaei, Aidin Esrafilian Soltani
Background: Gastric cancer is the second leading cause of cancer-related mortality and the fourth most common cancer globally. Tumor markers are needed for appropriate management and monitoring of treatment to improve quality of life. Recently, carcinoembryonic antigen (CEA) has been widely used as a tumor marker in the diagnosis and follow-up of some malignancies. The aim of this study was to evaluate the significance of CEA detection in the course of disease in gastric cancer patients at different stages...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29065877/postoperative-c-reactive-protein-albumin-ratio-as-a-novel-predictor-for-short-term-complications-following-gastrectomy-of-gastric-cancer
#11
Feng Sun, Xiaolong Ge, Zhijian Liu, Shangce Du, Shichao Ai, Wenxian Guan
BACKGROUND: Postoperative complications following gastric cancer resection remain a clinical problem. Early detection of postoperative complications is needed before critical illness develops. The purpose of this study was to evaluate the prognostic value of C-reactive protein/albumin ratio in patients with gastric cancer. METHODS: A total of 322 patients undergoing curative (R0) gastrectomy between 2015 and 2017 were retrospectively analyzed. Univariate and multivariate analyses were performed to identify clinical factors predicting postoperative complications...
October 24, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29051398/relationship-between-postoperative-complications-and-survival-after-gastrectomy-for-cancer
#12
Paolo Del Rio, Emiliano Bernuzzi, Elisa Bertocchi, Lorenzo Viani, Federico Cozzani, Chiara Montana
BACKGROUND: Surgical resection remains the main curative treatment for gastric cancer but is still affected by high postoperative morbidity and mortality rates, especially in Western countries. MATERIALS AND METHODS: We've analyzed patients treated for gastric cancer at our Operative Unit of ent, extent of lymphadenectomy and survival. General Surgery and Organ Transplantation of the University Hospital of Parma from January 2006 till December 2010, relating the occurrence of eventual complications to sex, age at diagnosis, definitive histological examination, type and duration of surgical treatment...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29046960/endoscopic-submucosal-dissection-for-undifferentiated-type-early-gastric-cancer-short-and-long-term-outcomes
#13
Hye Kyung Jeon, Seong Jun Lee, Gwang Ha Kim, Do Youn Park, Bong Eun Lee, Geun Am Song
BACKGROUND AND AIMS: Application of endoscopic submucosal dissection (ESD) for undifferentiated-type early gastric cancers (EGCs) remains controversial owing to limited data regarding long-term outcomes. We aimed to evaluate the feasibility of ESD for undifferentiated-type EGCs that meet the expanded criteria (EC). METHODS: We performed a retrospective analysis of 66 patients who underwent ESD for undifferentiated-type EGC between January 2005 and December 2014...
October 18, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29039602/lncrna-miat-regulates-cell-biological-behaviors-in-gastric-cancer-through-a-mechanism-involving-the-mir-29a-3p-hdac4-axis
#14
Yanfeng Li, Kuan Wang, Yuzhe Wei, Qiang Yao, Qifan Zhang, Hongyan Qu, Guanyu Zhu
Gastric cancer (GC) is one of the most common malignant diseases worldwide. Although significant progress has been made in the early detection and treatment of GC over the past decades, the prognosis is still not satisfactory and the underlying mechanisms of carcinogenesis remain unknown. Long non-coding RNA MIAT has been established as a key player in the regulation of various biological and pathological processes including chronic lymphocytic leukemias, acute myocardial infarction and neuroendocrine prostate cancer...
October 10, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29021452/a-case-of-familial-adenomatous-polyposis-with-multiple-helicobacter-negative-early-gastric-cancers-treated-by-endoscopic-submucosal-dissection
#15
Katsuki Yaguchi, Makomo Makazu, Kingo Hirasawa, Makoto Sugimori, Ryosuke Kobayashi, Chiko Sato, Ryosuke Ikeda, Takehide Fukuchi, Yasuaki Ishii, Hiroaki Kaneko, Wataru Shibata, Shoji Yamanaka, Yoshiaki Inayama, Shin Maeda
Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for MUC2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28989999/gallstone-cholecystectomy-and-risk-of-gastric-cancer
#16
Sung Hwa Kang, Young Hoon Kim, Young Hoon Roh, Kwan Woo Kim, Chan Joong Choi, Min Chan Kim, Su Jin Kim, Hee Jin Kwon, Jin Han Cho, Jin Seok Jang, Jong Hun Lee
BACKGROUNDS/AIMS: The aim of this retrospective study is to compare stomach cancer incidence, characteristics between gallstones, cholecystectomy and control groups. It also aims to investigate key variables' potential effects on overall survival. METHODS: A total of 99 patients, diagnosed with stomach cancers between April 1994 and December 2015, were identified. We excluded stomach cancer patients, accrued during the first year of follow-up in both the gallstones and cholecystectomy groups, assuming that they missed cancers...
August 2017: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/28987697/perfusion-ct-a-novel-quantitative-and-qualitative-imaging-biomarker-in-gastric-cancer
#17
Joanna Kruk-Bachonko, Witold Krupski, Michał Czechowski, Ewa Kurys-Denis, Przemysław Mądro, Jadwiga Sierocińska-Sawa, Andrzej Dąbrowski, Grzegorz Wallner, Tomasz Skoczylas
OBJECTIVES: The aim of this research was to examine whether Perfusion Computed Tomography (P-CT) can qualitatively and quantitatively help detect gastric cancer neoangiogenesis in vivo as well as treatment response evaluation. We attempted to explore which P-CT parameters are best used in neoangiogenesis and neoadjuvant therapy for most effective evaluation. We also tried to recognize a positive prediction value of P-CT in early responders and non-responders patients identification. MATERIALS AND METHODS: Twenty-four patients with positive biopsy results and/or clinically proven gastric cancer were enrolled in the P-CT exam...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987558/endoscopic-resection-versus-radical-gastrectomy-for-early-gastric-cancer-in-asia-a-meta-analysis
#18
REVIEW
Fei-Long Ning, Chun-Dong Zhang, Peng Wang, Shuai Shao, Dong-Qiu Dai
BACKGROUND: To compare the efficacy and safety of endoscopic resection (ER) and radical gastrectomy (RG) for early gastric cancer (EGC) in Asia. MATERIALS AND METHODS: We systematically searched relevant articles published before September 1, 2017. We evaluated the quality of the included non-randomized studies using the Newcastle-Ottawa Scale (NOS). Meta-analysis was carried out using RevMan 5.3 software. The odds ratio (OR) with 95% confidence intervals (CI) were used for the dichotomous data...
October 5, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28971758/circulating-micrornas-valuable-biomarkers-for-diagnosis-and-prognosis-of-gastric-cancer
#19
Najibeh Shekari, Behzad Baradaran, Dariush Shanehbandi, Tohid Kazemi
Gastric cancer (GC) as a global health problem is one of the deadliest cancer all over the world. Poor clinical symptoms, unfavorable prognosis and absence of proper diagnostic techniques for early detection cause GC as the third lethal cancer in the world. Presence of sensitive and specific biomarkers for early detection and monitoring the progression of GC could lead to the reduction of mortality. MicroRNAs (miRNAs) are gene regulator RNAs play important roles in tumorgenesis. In addition to intracellular miRNAs, circulating miRNAs faithfully reflect the state of cancer progression and provide a promising perspective on early diagnosis of GC...
October 3, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28970949/single-incision-laparoscopic-gastrectomy-for-gastric-cancer
#20
REVIEW
Yoontaek Lee, Hyung-Ho Kim
The implementation of national cancer screening has increased the detection rates of early gastric cancer (EGC) in Korea. Since the successful introduction of laparoscopic gastrectomy for gastric cancer in the early 1990s, this technique has demonstrated improved short-term outcomes without compromising long-term oncologic results. It is associated with reduced pain, shorter hospitalization, reduced morbidity rates, better cosmetic outcomes, and equivalent mortality rates as those for open surgery. Laparoscopic gastrectomy improves patients' quality of life (QOL) and provides favorable prognosis...
September 2017: Journal of Gastric Cancer
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