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Early gastric cancer detection

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https://www.readbyqxmd.com/read/29786128/long-term-oncologic-outcomes-of-laparoscopic-sentinel-node-navigation-surgery-in-early-gastric-cancer-a-single-center-single-arm-phase-ii-trial
#1
Do Joong Park, Young Suk Park, Sang Yong Son, Ju-Hee Lee, Hye Seung Lee, Young Soo Park, Kyoung Ho Lee, Young Hoon Kim, Kyoung Un Park, Won Woo Lee, Soyeon Ahn, Sang-Hoon Ahn, Hyung-Ho Kim
BACKGROUND: Sentinel node navigation surgery (SNNS) in early gastric cancer (EGC) is technically feasible according to previous literature, however its long-term oncologic safety has not been reported. METHODS: A single-center, single-arm, phase II trial was conducted to determine the oncologic outcomes of laparoscopic sentinel node (SN) biopsy in clinical stage T1N0M0 gastric cancer patients. Cases with positive SNs on intraoperative pathologic examination underwent conventional gastrectomy with radical lymphadenectomy (SN-positive group), whereas those with negative SNs underwent laparoendoscopic-limited gastric resections without further lymph node dissections (SN-negative group)...
May 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29780112/lymph-node-metastasis-of-mixed-adenoneuroendocrine-carcinoma-after-curative-resection-using-the-expanded-criteria-for-early-gastric-cancer
#2
Tadashi Ochiai, Masaki Ominami, Yasuaki Nagami, Shusei Fukunaga, Takahiro Toyokawa, Hirokazu Yamagami, Tetsuya Tanigawa, Toshio Watanabe, Masaichi Ohira, Masahiko Ohsawa, Yasuhiro Fujiwara
Endoscopic submucosal dissection (ESD) of lesions using expanded indications for early gastric cancer (EGC) has been accepted as an alternative treatment for cases without lymph node metastasis. We herein report a rare case of metastatic lymph node tissue in mixed adenoneuroendocrine carcinoma (MANEC) after curative ESD using the expanded pathological criteria. A 70-year-old man underwent ESD for two EGC lesions. A pathological examination revealed lesions that required curative resection based on the expanded pathological criteria of the Japanese classification of gastric carcinoma...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29779861/hopq-impacts-the-integrin-%C3%AE-5%C3%AE-1-independent-nf-%C3%AE%C2%BAb-activation-by-helicobacter-pylori-in-ceacam-expressing-cells
#3
Michael Hartmut Feige, Olga Sokolova, Anna Pickenhahn, Gunter Maubach, Michael Naumann
Helicobacter pylori infection persists in more than half of the world's population and represents a risk factor for peptic ulcer disease and gastric cancer. Virulent strains of H. pylori carry a cag pathogenicity island (cagPAI), which encodes a type IV secretion system (T4SS) with the capability to inject the effector protein cytotoxin-associated gene A (CagA) into eukaryotic cells. Colonisation of the gastric epithelium by H. pylori provokes direct activation of the proinflammatory and survival factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)...
May 14, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29779696/preliminary-study-of-magnetically-controlled-capsule-gastroscopy-for-diagnosing-superficial-gastric-neoplasia
#4
Yang-Yang Qian, Shu-Guang Zhu, Xi Hou, Wei Zhou, Wei An, Xiao-Ju Su, Mark Edward McAlindon, Zhao-Shen Li, Zhuan Liao
BACKGROUND: Magnetically controlled capsule gastroscopy (MCCG) is a newly developed non-invasive method designed for gastric examination. Although favorable diagnostic accuracy has been reported, there is little if any data about its ability to diagnose gastric cancer. AIMS: To compare the detectability of superficial gastric neoplasia by MCCG and gastroscopy. METHODS: This study was a self-controlled comparison study. Ten subjects diagnosed with superficial gastric neoplasia and scheduled to undergo endoscopic submucosal dissection (ESD) at a tertiary hospital were prospectively invited for an MCCG examination...
April 24, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29774942/-progress-and-controversy-on-diagnosis-and-treatment-of-gastric-stump-cancer
#5
Zhidong Gao, Yongbai Li, Kewei Jiang, Yingjiang Ye, Shan Wang
Gastric stump cancer (GSC) is a carcinoma arising from the remnant stomach following gastric surgery for benign or malignant disease, and is more common in men. The risk of morbidity has an obvious time dependence. GSC incidence is likely to rise with lengthening of the initial operation interval. The GSC time interval after malignant disease is significantly shorter than that of benign disease. GSC etiologies mainly include duodenogastric reflux and denervation of the gastric mucosa resulting in the change of the gastric environment after gastrectomy and the Helicobacter pylori infection...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774929/-epidemiological-characteristics-and-inducing-factors-of-gastric-stump-cancer
#6
Lin Chen
Gastric stump cancer was initially defined as a carcinoma of the stomach occurring more than 5 years after surgery for gastric or duodenal benign disease. In recent years, as the number of total gastrectomy for benign disease has gradually decreased and the gastric cancer detection and operation rate have annually increased, residual recurrence of primary gastric cancer more than 10 years after gastric cancer surgery has also been considered as gastric stump cancer. The incidence of gastric stump cancer is increasing annually...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29755768/detecting-promoter-methylation-pattern-of-apoptotic-genes-apaf1-and-caspase8-in-gastric-carcinoma-patients-undergoing-chemotherapy
#7
Fatemeh Azarkhazin, Golnaz Asaadi Tehrani
Background: DNA methylation patterns in cells dysregulation CpG island methylation of genes involved in cancer leads to increased levels of the cancer. Restoration of the apoptotic route in tumor cells of stomach in order for placing Casp8 and Apaf1 genes is a proper approach for new treatments of gastric cancer. The objective of the present study was to investigate the relationship between the pattern of methylation promoter in apoptotic genes of Casp8 and Apaf1 and gastric carcinoma in patients receiving chemotherapy...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29743854/microsatellite-instability-in-colorectal-cancer
#8
REVIEW
Jafar Nouri Nojadeh, Shahin Behrouz Sharif, Ebrahim Sakhinia
Colorectal cancer (CRC) is a heterogeneous disease that is caused by the interaction of genetic and environmental factors. Although it is one of the most common cancers worldwide, CRC would be one of the most curable cancers if it is detected in the early stages. Molecular changes that occur in colorectal cancer may be categorized into three main groups: 1) Chromosomal Instability (CIN), 2) Microsatellite Instability (MSI), and 3) CpG Island Methylator phenotype (CIMP). Microsatellites, also known as Short Tandem Repeats (STRs) are small (1-6 base pairs) repeating stretches of DNA scattered throughout the entire genome and account for approximately 3 % of the human genome...
2018: EXCLI journal
https://www.readbyqxmd.com/read/29743108/-18-fdg-pet-ct-identifies-histopathological-non-responders-after-neoadjuvant-chemotherapy-in-locally-advanced-gastric-and-cardia-cancer-cohort-study
#9
Paul M Schneider, Dilmurodjon Eshmuminov, Tamara Rordorf, Diana Vetter, Patrick Veit-Haibach, Achim Weber, Peter Bauerfeind, Panagiotis Samaras, Kuno Lehmann
BACKGROUND: Pathologic response to neoadjuvant chemotherapy (neoCTX) is a prognostic factor in many cancer types, and early prediction would help to modify treatment. In patients with gastric and esophagogastric junction (AEG) cancer, the accuracy of FDG PET-CT to predict early pathologic response after neoadjuvant chemotherapy (neoCTX) is currently not known. METHODS: From a consecutive cohort of 72 patients, 44 patients with resectable, locally-advanced gastric cancer or AEG Siewert type II and III received neoCTX after primary staging with endoscopic ultrasound, PET-CT and laparoscopy...
May 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29742692/five-common-tumor-biomarkers-and-cea-for-diagnosing-early-gastric-cancer-a-protocol-for-a-network-meta-analysis-of-diagnostic-test-accuracy
#10
Minghui Shen, Hui Wang, Kongyuan Wei, Jianling Zhang, Chongge You
BACKGROUND: Although surgical resection is the recommended treatment for the patients with gastric cancer, lots of patients show advanced or metastatic gastric cancer at the time of diagnosis. Detection of gastric cancer at early stages is a huge challenge because of lack of appropriate detection tests. Unfortunately, existing clinical guidelines focusing on early diagnosis of gastric cancer do not provide consistent and prudent evidence. Serum carcinoembryonic antigen was considered as a complementary test, although it is not good enough to diagnose early gastric cancer...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29736829/circulating-microrna-22-3p-predicts-the-malignant-progression-of-precancerous-gastric-lesions-from-intestinal-metaplasia-to-early-adenocarcinoma
#11
Tsung-Hsing Chen, Cheng-Tang Chiu, Chieh Lee, Yin-Yi Chu, Hao-Tsai Cheng, Jun-Te Hsu, Ren-Chin Wu, Ta-Sen Yeh, Kwang-Huei Lin
BACKGROUND: Gastric cancer has a poor outcome and identifying useful biomarkers from peripheral blood or tissue could allow its early detection, or potentially precancerous changes, thus improving the curative rates. MicroRNAs (miRNAs) have been shown to offer great potential in cancer diagnosis and prediction. AIM: Here, we investigated the role of plasma miRNAs in the natural course of gastric cancer, from intestinal metaplasia to early cancer. The findings were used to understand whether patients at a high risk of malignancy could be given appropriate interventions in the early disease process, such as using endoscopic submucosal dissection to treat gastric dysplasia or early gastric cancer...
May 7, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29736661/abdominal-drainage-and-amylase-measurement-for-detection-of-leakage-after-gastrectomy-for-gastric-cancer
#12
Judith P M Schots, Misha D P Luyer, Grard A P Nieuwenhuijzen
PURPOSE: To investigate the value of daily measurement of drain amylase for detecting leakage in gastric cancer surgery. METHODS: This was a retrospective analysis including all patients who underwent a gastrectomy for gastric cancer. From January 2013 until December 2015, an intra-abdominal drain was routinely placed. Drain amylase was measured daily. Receiver operator characteristic curves were created to assess the ability of amylase to predict leakage. Sensitivity, specificity, and negative and positive predictive value of amylase in drain fluid were determined...
May 7, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29729233/simultaneous-quantitation-of-carbohydrate-antigen-125-and-carcinoembryonic-antigen-in-human-serum-via-time-resolved-fluoroimmunoassay
#13
Zhen Huang, Xiang-Ming Zhai, Hao Wang, Qiao-Ting Deng, Kun Li, Bi-Sen Liu, Gang Wang, Tian-Cai Liu
In clinical diagnosis of cancer, immunology assay with single tumor marker often lead to a false and missed inspection. A quantitative method with a high degree of accuracy, sensitivity, and effectiveness is required for its diagnosis. We developed a dual-label time-resolved fluoroimmunoassay (TRFIA) to simultaneously detect carbohydrate antigen 125 (CA125) and carcinoembryonic antigen (CEA) in human serum to aid the diagnosis and prognosis of gastric cancer. The method was based on a microplate sandwich immunoassay using europium-labeled anti-CA125 antibodies and samarium-labeled anti-CEA antibodies as fluorescent reporters...
May 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29722342/gastric-cancer-screening-by-combined-determination-of-serum-helicobacter-pylori-antibody-and-pepsinogen-concentrations-abc-method-for-gastric-cancer-screening
#14
REVIEW
Xian-Zhe Chen, Cheng-Zhi Huang, Wei-Xian Hu, Ying Liu, Xue-Qing Yao
Objective: Gastroscopy combined with gastric mucosa biopsies is currently regarded as a gold standard for diagnosis of gastric cancer. However, its application is restricted in clinical practice due to its invasive property. A new noninvasive population screening process combining the assay of anti-Helicobacter pylori antibody and serum pepsinogen (PG) (ABC method) is adopted to recognize the high-risk patients for further endoscopy examination, avoiding the unnecessary gastroscopy for most population and saving the cost consumption for mass screening annually...
May 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29719906/totally-laparoscopic-versus-open-gastrectomy-for-gastric-cancer-a-matched-pair-analysis
#15
Kaja Ludwig, Sylke Schneider-Koriath, Uwe Scharlau, Holger Steffen, Daniela Möller, Jörn Bernhardt
BACKGROUND: Laparoscopic gastrectomy has been established for treatment of early gastric cancer (EGC) especially in Eastern Asian countries. Currently, it still needs evaluation for advanced gastric cancer (AGC, T ≥ 2). Difficulty is how far Asian study data are valid for western conditions. METHODS: Out of 502 patients who underwent gastric cancer surgery between 2003 and 2016 at Klinikum Suedstadt Rostock 90 patients were selected for a retrospective study to compare totally laparoscopic D2-gastrectomy (LG, n = 45) with open D2-gastrectomy (OG, n = 45)...
April 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29700972/a-panel-consisting-of-three-novel-circulating-lncrnas-is-it-a-predictive-tool-for-gastric-cancer
#16
Jingjing Liu, Jiajun Wang, Yongxi Song, Bin Ma, Junlong Luo, Zhongran Ni, Peng Gao, Jingxu Sun, Junhua Zhao, Xiaowan Chen, Zhenning Wang
Early detection is vital for prolonging 5-year survival for patients with gastric cancer (GC). Numerous studies indicate that circulating long non-coding RNAs (lncRNAs) can be used to diagnose malignant tumours. This study aimed to investigate the capacity of novel lncRNAs for diagnosing GC. A lncRNA microarray assay was used to screen differentially expressed lncRNAs between plasma of patients with GC and healthy controls. Plasma samples from 100 patients with healthy controls were used to construct a multiple-gene panel...
April 26, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29666402/expression-of-kk-lc-1-a-cancer-testis-antigen-at-non-tumour-sites-of-the-stomach-carrying-a-tumour
#17
Takashi Fukuyama, Nobue Futawatari, Rui Yamamura, Taiga Yamazaki, Yoshinobu Ichiki, Akira Ema, Hideki Ushiku, Yatsushi Nishi, Yoshihito Takahashi, Toshikazu Otsuka, Hitoshi Yamazaki, Wasaburo Koizumi, Kosei Yasumoto, Noritada Kobayashi
Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) and predominant target for cancer immunotherapy. Our previous study indicated that KK-LC-1 was expressed in 82% of gastric cancers, and also in 79% of early stage of gastric cancers, with a correlation to Helicobacter pylori (H. pylori) infection. In addition, we found that KK-LC-1 was occasionally expressed at non-tumour sites of stomachs carrying tumours. Here, we investigated the characteristics of KK-LC-1 expression at non-tumour sites and the clinical utility of these phenomena...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29664654/annual-trends-of-gastrointestinal-cancers-mortality-in-iran-during-1990-2015-nasbod-study
#18
Hamideh Salimzadeh, Farnaz Delavari, Catherine Sauvaget, Negar Rezaee, Alireza Delavari, Farzad Kompani, Nazila Rezaei, Ali Sheidaei, Mitra Modirian, Rosa Haghshenas, Maryam Chegini, Kimiya Gohari, Hossein Zokaiee, Farshad Farzadfar, Reza Malekzadeh
BACKGROUND: Gastrointestinal (GI) neoplasms are among the most common cancers in Iran. This study aimed to measure annual trends in mortality rates from GI cancers in Iran between 1990 and 2015. METHODS: This study was part of an ongoing study termed the 'National and Subnational Burden of Diseases' study in Iran. Data used in this study was obtained from the Iranian Death Registration System (1995 to 2010) and from 2 major cemeteries in Tehran (1995 to 2010) and Isfahan (2007 to 2010)...
February 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29650930/-a-case-of-early-gastric-cancer-with-multiple-lymph-node-metastases-revealed-by-additional-surgical-resection-after-esd
#19
Yoshitaka Nakamura, Masayuki Yubakami, Yutaka Kondo, Yukihisa Nishimura, Momoko Todo, Kiyoto Atsuji, Akihiro Yamaguchi, Naoki Kakihara, Osamu Ikawa, Hiroki Taniguchi
A 74-year-old man was referred to our hospital for further investigation of a cystic lesion in the pancreatic body, which had been detected by ultrasonography at a local hospital. He was diagnosed as intraductal papillary mucinous neoplasm(IPMN) and further preoperative examinations were conducted. Upper gastrointestinal endoscopy demonstrated a type 0-II c tumor of the greater curvature in the upper third of the stomach. Endoscopic ultrasonography showed no sign of submucosal invasion. Endoscopic submucosal dissection(ESD)was carried out and pathological examination of a specimen revealed well differentiated adenocarcinoma with submucosal invasion, which fulfilled the indication for additional gastrectomy with lymph node dissection...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650923/-a-case-of-gastric-gist-with-pathological-complete-response-achieved-by-long-term-chemotherapy-with-imatinib-mesylate
#20
Junya Kondo, Hikari Chijimatsu, Taiki Kijima, Yukiko Nagashima, Hideto Hayashi, Katsuhiko Morita, Kouichiro Sakata, Mihoko Setoguchi
A 78-year-old woman was diagnosed with a gastrointestinal stromal tumor(GIST)of the stomach, gradually increasing from 5 years prior. The tumor was suspected to invade the pancreatic body tail and spleen, as observed with computed tomography. Because the patient refused to undergo resection, we administered imatinib mesylate for 6 years. Since early rectal cancer was revealed, the patient was referred for resection and underwent laparoscopic low anterior resection and partial gastrectomy. Histopathologically, the tumor was replaced by tissues with myxomatous changes, and no viable tumor cells were detected...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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