keyword
MENU ▼
Read by QxMD icon Read
search

Early gastric cancer detection

keyword
https://www.readbyqxmd.com/read/27915451/interobserver-agreement-in-detection-of-white-globe-appearance-and-the-ability-of-educational-lectures-to-improve-the-diagnosis-of-gastric-lesions
#1
Hitoshi Omura, Naohiro Yoshida, Tomoyuki Hayashi, Kazuhiro Miwa, Hajime Takatori, Hirokazu Tsuji, Katsuhisa Inamura, Yukihiro Shirota, Hiroyuki Aoyagi, Takaharu Masunaga, Kazuyoshi Katayanagi, Hiroshi Kurumaya, Shuichi Kaneko, Hisashi Doyama
BACKGROUND: White globe appearance (WGA) refers to a small white lesion of globular shape underneath cancerous gastric epithelium that can be clearly visualized by magnifying endoscopy with narrowband imaging (M-NBI). WGA has been reported to be a novel endoscopic marker that is highly specific in differentiating early gastric cancer (GC) from low-grade adenoma, and has a significantly higher prevalence in early GCs than in noncancerous lesions. However, interobserver agreement in detecting WGA and whether training intervention can improve diagnostic accuracy are unknown...
December 3, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27895391/characteristics-of-gastric-cancer-detected-within-1-year-after-successful-eradication-of-helicobacter-pylori
#2
Toshihiro Nishizawa, Hidekazu Suzuki, Toru Arano, Shuntaro Yoshida, Hiroharu Yamashita, Keisuke Hata, Takanori Kanai, Naohisa Yahagi, Osamu Toyoshima
Gastric cancers are sometimes diagnosed in patients who have successfully undergone Helicobacter pylori (H. pylori) eradication. We analyzed the clinicopathological features of gastric cancers detected after eradication to clarify their characteristics. We reviewed 31 patients with 34 cases of gastric cancer detected after successful H. pylori eradication. Clinicopathological characteristics analyzed included interval since eradication, interval since last endoscopy, tumor size, and depth of invasion. Patients were classified into two groups: early detection (<1 year since eradication) and delayed detection (≥1 year since eradication)...
November 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27884752/quantitative-proteomic-analysis-reveals-that-proteins-required-for-fatty-acid-metabolism-may-serve-as-diagnostic-markers-for-gastric-cancer
#3
Zhen Jiang, Hongchun Shen, Bo Tang, Qin Yu, Xingli Ji, Li Wang
BACKGROUND: Gastric cancer is one of the leading causes of cancer-related deaths worldwide. The sensitivities and specificities of current biomarkers for gastric cancer are insufficient for clinical detection, and new diagnostic tests are therefore urgently required. METHODS: A discovery set of gastric cancer and adjacent normal tissues were analyzed for differentially expressed proteins by labeling of peptide digests with isobaric tag for relative and absolute quantitation (iTRAQ) reagents followed by liquid chromatography-electrospray ionization-tandem mass spectrometry...
November 21, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27875523/a-protein-fragment-derived-from-dna-topoisomerase-i-as-a-novel-tumour-associated-antigen-for-the-detection-of-early-stage-carcinoma
#4
Shang-Mian Yie, Shang-Rong Ye, Xiao-Li Ma, Ke Xie, Jian-Bo Zhang, Mei Cao, Xu He, Zhen-Bo Hu, Cheng-Lu Yang, Jia Zhang, Jie Zeng
BACKGROUND: The production of autoantibodies against tumour-associated antigens (TAAs) is believed to reflect greater immunologic reactivity in cancer patients and enhanced immune surveillance for cancer cells. Over the past few decades, a number of different TAAs and their corresponding autoantibodies have been investigated. However, positive frequency of autoantibody detection in cancer patients has been relatively low. Here we describe a novel TAA that was a fragment derived from human DNA-topoiomerase I and an autoantibody against the novel TAA with relatively high positive frequency in the sera of early-stage non-small-cell lung cancer (NSCLC), gastric cancer (GC), colorectal cancer (CRC) and oesophageal squamous cell carcinoma (ESCC)...
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27864121/gene-amplification-of-ccne1-ccnd1-and-cdk6-in-gastric-cancers-detected-by-multiplex-ligation-dependent-probe-amplification-and-fluorescence-in-situ-hybridization
#5
Akishi Ooi, Takeru Oyama, Ritsuko Nakamura, Ryousuke Tajiri, Hiroko Ikeda, Sachio Fushida, Yoh Dobashi
New and effective treatments for advanced gastric cancer are urgently needed. Cyclins E and D1 form a complex with cyclin-dependent kinase 2 (CDK2), 4 or 6 to regulate G1-S transition. The G1-S regulatory genes encoding cyclin E (CCNE1), cyclin D1 (CCND1) and CDK6 (CDK6) are frequently amplified in gastric cancer and may therefore influence molecularly targeted therapies against ERBB2 or EGFR when co-amplified. A total of 179 formalin-fixed and paraffin-embedded gastric cancer specimens were examined for these gene amplifications by multiplex ligation-dependent probe amplification (MLPA) and fluorescence in situ hybridization (FISH)...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27845158/the-application-of-nanoparticles-in-diagnosis-and-theranostics-of-gastric-cancer
#6
Rutian Li, Baorui Liu, Jiahui Gao
Gastric cancer is the fourth most common cancer and the second leading cause of cancer related death worldwide. For the diagnosis of gastric cancer, apart from regular systemic imaging, the locoregional imaging is also of great importance. Moreover, there are still other ways for the detecting of gastric cancer, including the early detection of gastric cancer by endoscopy, the detection of gastric-cancer related biomarkers and the detection of circulating tumor cells (CTCs) of gastric cancer. However, conventional diagnostic methods are usually lack of specificity and sensitivity...
November 11, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27810400/clinical-impact-of-colonoscopy-for-patients-with-early-gastric-cancer-treated-by-endoscopic-submucosal-dissection-a-matched-case-control-study
#7
Kenichiro Imai, Kinichi Hotta, Yuichiro Yamaguchi, Noboru Kawata, Naomi Kakushima, Masaki Tanaka, Kohei Takizawa, Hiroyuki Matsubayashi, Tadakazu Shimoda, Keita Mori, Hiroyuki Ono
BACKGROUND: Gastric cancer frequently occurs synchronously with colorectal cancer (CRC). AIMS: The aim of the present study was to assess the value of colonoscopy in patients with primariy early gastric cancer (EGC) indicated for endoscopic submucosal dissection (ESD) and to identify predictors for the risk of high-risk adenomas. METHODS: A total of 130 patients with EGC, who underwent both colonoscopy and gastric ESD, and 260 controls matched for age and sex, who underwent a colonoscopy as part of our institutional health check-up program...
October 17, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27797257/diagnostic-power-of-blood-parameters-as-screening-markers-in-gastric-cancer-patients
#8
Lukasz Pietrzyk, Zbigniew Plewa, Marta Denisow-Pietrzyk, Remigiusz Zebrowski, Kamil Torres
BACKGROUND: Gastric cancer (GC) is the fifth most common cancer worldwide. Since development is usually asymptomatic, it is generally diagnosed at an advanced stage. The value of screening in patients with nonspecific symptoms for GC is controversial. AIM: The study aimed to evaluate whether hematological parameters (platelet count (PC), mean platelet volume (MPV), MPV/PC ratio, red blood cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR)) are useful markers to differentiate between gastric cancer patients and healthy individuals...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27778124/early-detection-of-nonperitoneal-recurrence-may-contribute-to-survival-benefit-after-curative-gastrectomy-for-gastric-cancer
#9
Keiichi Fujiya, Masanori Tokunaga, Rie Makuuchi, Noriyuki Nishiwaki, Hayato Omori, Wataru Takagi, Fumiko Hirata, Makoto Hikage, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Masanori Terashima
BACKGROUND: There is no evidence that strict follow-up using cross-sectional imaging after curative gastrectomy benefits survival; however, nonperitoneal recurrence detected early might be treated with additional surgery. The present study examined whether early detection of recurrence by imaging modalities could increase survival, particularly in patients with nonperitoneal recurrence. METHODS: We retrospectively analyzed 218 patients with recurrent gastric cancer after curative gastrectomy performed from 2002 to 2014...
October 24, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27752392/usefulness-of-endoscopic-imaging-to-visualize-regional-alterations-in-acid-secretion-of-noncancerous-gastric-mucosa-after-helicobacter-pylori-eradication
#10
Kaname Uno, Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Yasushi Takahashi, Nobuyuki Ara, Tooru Shimosegawa
PURPOSE: Endoscopic diagnosis of gastric cancer (GC) that emerges after eradication of Helicobacter pylori may be affected by unique morphological changes. Using comprehensive endoscopic imaging, which can reveal biological alterations in gastric mucosa after eradication, previous studies demonstrated that Congo red chromoendoscopy (CRE) might clearly show an acid non-secretory area (ANA) with malignant potential, while autofluorescence imaging (AFI) without drug injection or dyeing may achieve early detection or prediction of GC...
September 2016: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/27741275/the-implications-of-endoscopic-ulcer-in-early-gastric-cancer-can-we-predict-clinical-behaviors-from-endoscopy
#11
Yoo Jin Lee, Jie-Hyun Kim, Jae Jun Park, Young Hoon Youn, Hyojin Park, Jong Won Kim, Seung Ho Choi, Sung Hoon Noh
BACKGROUND: The presence of ulcer in early gastric cancer (EGC) is important for the feasibility of endoscopic resection, only a few studies have examined the clinicopathological implications of endoscopic ulcer in EGC. OBJECTIVES: To determine the role of endoscopic ulcer as a predictor of clinical behaviors in EGC. METHODS: Data of 3,270 patients with EGC who underwent surgery between January 2005 and December 2012 were reviewed. Clinicopathological characteristics were analyzed in relation to the presence and stage of ulcer in EGC...
2016: PloS One
https://www.readbyqxmd.com/read/27725906/microrna-17-5p-promotes-gastric-cancer-proliferation-migration-and-invasion-by-directly-targeting-early-growth-response-2
#12
Peng Chen, Huasi Zhao, Jingjing Huang, Xizhong Yan, Yunfei Zhang, Yongshun Gao
MicroRNA-17-5p (miR-17-5p) has previously been reported to play an important role in tumor development and progression. However, it functions differently regarding different kinds of malignant tumor, and its role and mechanism in gastric cancer (GC) still lacks investigation. In this study, we detected the relationship between miR-17-5p and the development of GC by qRT-PCR, and it turned out that the level of miR-17-5p was significantly higher in GC patients than that in normal controls, and the aberrant expression of miR-17-5p was correlated with lymph node metastasis...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27722599/glycomic-profiling-of-targeted-serum-haptoglobin-for-gastric-cancer-using-nano-lc-ms-and-lc-ms-ms
#13
Sung Hyeon Lee, Seunghyup Jeong, Jua Lee, In Seok Yeo, Myung Jin Oh, Unyong Kim, Sumin Kim, Su Hee Kim, Seung-Yeol Park, Jae-Han Kim, Se Hoon Park, Jung Hoe Kim, Hyun Joo An
Gastric cancer has one of the highest cancer mortality rates worldwide, largely because of difficulties in early-stage detection. Aberrant glycosylation in serum proteins is associated with many human diseases including inflammation and various types of cancer. Serum-based global glycan profiling using mass spectrometry has been explored and has already led to several potential glycan markers for several disease states. However, localization of the aberrant glycosylation is desirable in order to improve the specificity and sensitivity for clinical use...
October 5, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27722152/etiology-and-prevention-of-esophageal-cancer
#14
Chung S Yang, Xiaoxin Chen, Shuiping Tu
BACKGROUND: Esophageal cancer (EC) occurs commonly, especially in Asia, and is the sixth leading cause of cancer deaths worldwide. Recently, great progress has been made in research on the etiology and prevention of EC. SUMMARY: The major risk factors for esophageal squamous cell carcinoma (ESCC) are tobacco smoking and alcohol drinking, which act synergistically. Dietary parameters, including dietary carcinogens and insufficiency of micronutrients, could also be important risk factors in certain areas...
September 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27718753/proteomics-approach-to-identify-biomarkers-for-upper-gastrointestinal-cancer
#15
Kazuto Harada, Dilsa Mizrak Kaya, Yusuke Shimodaira, Shumei Song, Hideo Baba, Jaffer A Ajani
The prognosis for patients with upper gastrointestinal cancers remains dismal despite the development of multimodality therapies that incorporate surgery, chemotherapy, and radiotherapy. Early diagnosis and personalized treatment should lead to better prognosis. Given the advances in proteomic technologies over the past decades, proteomics promises to be the most effective technique to identify novel diagnostics and therapeutic targets. Areas covered: For this review, keywords were searched in combination with "proteomics" and "gastric cancer" or "esophageal cancer" in PubMed...
October 10, 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27714472/function-preserving-gastrectomy-based-on-the-sentinel-node-concept-in-early-gastric-cancer
#16
Hiroya Takeuchi, Osamu Goto, Naohisa Yahagi, Yuko Kitagawa
Recent meta-analyses and a prospective multicenter trial of sentinel node (SN) mapping in early gastric cancer have demonstrated acceptable SN detection rates and accuracy of determination of lymph node status. SN mapping may play a key role in obtaining individual metastatic information. It also allows modification of surgical procedures, including function-preserving gastrectomy in patients with early gastric cancer. A dual-tracer method that uses radioactive colloids and blue dye is currently considered the most reliable method for the stable detection of SNs in patients with early gastric cancer...
October 6, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27703523/mean-platelet-volume-provides-beneficial-diagnostic-and-prognostic-information-for-patients-with-resectable-gastric-cancer
#17
Xiao-Ming Shen, You-You Xia, Lian Lian, Chong Zhou, Xiang-Li Li, Shu-Guang Han, Yan Zheng, Fei-Ran Gong, Min Tao, Zhong-Qi Mao, Wei Li
Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related mortalities worldwide. Platelets play an important and multifaceted role in cancer progression. Elevated mean platelet volume (MPV) detected in peripheral blood has been identified in various types of cancer. In the present study, we investigated the application value of MPV in early diagnostic and prognostic prediction in patients with resectable gastric cancer. In total, 168 patients with resectable gastric cancer were included and separated into the gastric cancer and healthy control groups according to median pre-operatic MPV value (MPV low, <10...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27698878/tumor-suppressing-effects-of-microrna-429-in-human-renal-cell-carcinoma-via-the-downregulation-of-sp1
#18
Deyao Wu, Xiaobing Niu, Huixing Pan, Yunfeng Zhou, Zichun Zhang, Ping Qu, Jian Zhou
MicroRNA (miR)-429 has been frequently reported to be downregulated in various tumors, including renal cell carcinoma (RCC), nasopharyngeal carcinoma, Ehrlich ascites tumor cells, gastric cancer, non-small cell lung cancer and endometrial endometrioid carcinoma. The present study investigated the effects of miR-429 on human RCC A498 and 786-O cells. Following transfection of cells with miR-429 mimics and scrambled control, MTT, cell migration, cell invasion and luciferase assays were performed. In addition, western blotting was performed in order to assess the expression of specificity protein 1 (Sp1), which was predicted to be a target of miR-429 by TargetScan...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27685925/incidence-mortality-and-epidemiological-aspects-of-cancers-in-iran-differences-with-the-world-data
#19
Zeinab Almasi, Abdollah Mohammadian-Hafshejani, Hamid Salehiniya
PURPOSE: No comprehensive study of cancer incidence and mortality exists in Iran. This study aimed to evaluate the incidence, mortality and epidemiological aspects of cancers in our country. METHODS: In this study, information of cancer incidence and mortality in Iran was retrieved from International Cancer Registry data and reported by numbers, crude and standardized incidence and mortality rates. Cancer incidence and mortality in Iran were mapped and compared with neighboring countries and the world...
July 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27651161/rad51b-as-a-potential-biomarker-for-early-detection-and-poor-prognostic-evaluation-contributes-to-tumorigenesis-of-gastric-cancer
#20
Yikun Cheng, Bin Yang, Yanfeng Xi, Xing Chen
Gastric cancer (GC) is a common and deadly disease worldwide. Outcomes of patients are poor largely due to chemoresistance or recurrence. Thus, identifying novel biomarkers to predict response to therapy and/or prognosis are urgently needed. RAD51B, a key player in DNA repair/recombination, has the potential to be a candidate oncogene and biomarker for cancer diagnosis and prognosis. However, its relationship with GC remains unclear. To evaluate clinicopathological and prognostic significance of RAD51B in GC, we examined messenger RNA (mRNA) and protein expression via quantitative real-time polymerase chain reaction (qRT-PCR) from 69 and tissue microarray from 144 GC patients, respectively...
September 20, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
keyword
keyword
118942
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"