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https://www.readbyqxmd.com/read/27933283/neonatal-diagnostics-toward-dynamic-growth-charts-of-neuromotor-control
#1
Elizabeth B Torres, Beth Smith, Sejal Mistry, Maria Brincker, Caroline Whyatt
The current rise of neurodevelopmental disorders poses a critical need to detect risk early in order to rapidly intervene. One of the tools pediatricians use to track development is the standard growth chart. The growth charts are somewhat limited in predicting possible neurodevelopmental issues. They rely on linear models and assumptions of normality for physical growth data - obscuring key statistical information about possible neurodevelopmental risk in growth data that actually has accelerated, non-linear rates-of-change and variability encompassing skewed distributions...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27926975/large-for-gestational-age-infants-and-adverse-outcomes-among-uncomplicated-pregnancies-at-term
#2
Hector Mendez-Figueroa, Van Thi Thanh Truong, Claudia Pedroza, Suneet P Chauhan
Background While traumatic delivery with large for gestational age (LGA; birth weight above 90%) is acknowledged, there is paucity of data regarding other morbidity and mortality associated with LGA. Our hypothesis was that compared with appropriate for gestational age (AGA), LGA have a significantly higher rate of composite neonatal morbidity (CNM). Objective Our objective was to compare the CNM among uncomplicated LGA versus AGA at term (37 weeks or more) among all available Maternal-Fetal Medicine Units (MFMU) databases...
December 7, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27926647/central-fetal-monitoring-with-and-without-computer-analysis-a-randomized-controlled-trial
#3
Inês Nunes, Diogo Ayres-de-Campos, Austin Ugwumadu, Pina Amin, Philip Banfield, Antony Nicoll, Simon Cunningham, Paulo Sousa, Cristina Costa-Santos, João Bernardes
OBJECTIVE: To evaluate whether intrapartum fetal monitoring with computer analysis and real-time alerts decreases the rate of newborn metabolic acidosis or obstetric intervention when compared with visual analysis. METHODS: A randomized clinical trial carried out in five hospitals in the United Kingdom evaluated women with singleton, vertex fetuses of 36 weeks of gestation or greater during labor. Continuous central fetal monitoring by computer analysis and online alerts (experimental arm) was compared with visual analysis (control arm)...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27923401/effectiveness-of-the-who-safe-childbirth-checklist-program-in-reducing-severe-maternal-fetal-and-newborn-harm-in-uttar-pradesh-india-study-protocol-for-a-matched-pair-cluster-randomized-controlled-trial
#4
Katherine E A Semrau, Lisa R Hirschhorn, Bhala Kodkany, Jonathan M Spector, Danielle E Tuller, Gary King, Stuart Lipsitz, Narender Sharma, Vinay Pratap Singh, Bharath Kumar, Neelam Dhingra-Kumar, Rebecca Firestone, Vishwajeet Kumar, Atul A Gawande
BACKGROUND: Effective, scalable strategies to improve maternal, fetal, and newborn health and reduce preventable morbidity and mortality are urgently needed in low- and middle-income countries. Building on the successes of previous checklist-based programs, the World Health Organization (WHO) and partners led the development of the Safe Childbirth Checklist (SCC), a 28-item list of evidence-based practices linked with improved maternal and newborn outcomes. Pilot-testing of the Checklist in Southern India demonstrated dramatic improvements in adherence by health workers to essential childbirth-related practices (EBPs)...
December 7, 2016: Trials
https://www.readbyqxmd.com/read/27922698/differentially-expressed-mirnas-in-oxygen%C3%A2-induced-retinopathy-newborn-mouse-models
#5
Yunpeng Wang, Suying Wu, Yang Yang, Fen Peng, Qintao Li, Peng Tian, Erying Xiang, Honglu Liang, Beibei Wang, Xiaoyu Zhou, Hua Huang, Xiaoguang Zhou
The present study aimed to identify microRNAs (miRNAs) involved in regulating retinal neovascularization and retinopathy of prematurity (ROP). A total of 80 healthy C57BL/6 neonatal mice were randomly divided into the oxygen‑induced retinopathy (OIR) group (n=40), in which 7‑day‑old mice were maintained in 75% oxygen conditions for 5 days, or the control group (n=40). Following collection of retinal tissue, retinal angiography and hematoxylin and eosin (H&E) staining were performed. Total RNA was also extracted from retinal tissue, and miRNA microarrays and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) were performed to identify differentially expressed miRNAs in the two groups...
December 6, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27918382/conventional-versus-prolonged-infusion-of-meropenem-in-neonates-with-gram-negative-late-onset-sepsis-a-randomized-controlled-trial
#6
Abd Elazeez Shabaan, Islam Nour, Heba Elsayed Eldegla, Nehad Nasef, Basma Shouman, Hesham Abdel-Hady
BACKGROUND: Gram-negative bacteria are associated with significant morbidity and mortality in preterm and term newborns. Meropenem has widespread efficacy and often allows for monotherapy in this group. Prolonged infusion instead of infusion over 30 minutes has been suggested to result in higher microbiologic efficacy. OBJECTIVE: To compare the clinical and microbiologic efficacy and safety of prolonged infusions versus conventional dosing of meropenem in neonates with Gram negative late onset sepsis (GN-LOS)...
November 30, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27913258/an-experimental-study-on-the-effects-of-smoking-in-the-perinatal-period-and-during-lactation-on-the-intervertebral-discs-of-newborns
#7
Idiris Altun, Kasım Z Yuksel
OBJECTIVE: To evaluate the histopathological effects of smoking before, during and after pregnancy on the intervertebral disc structure of the newborns in an experimental rat model. METHODS: Seven adult female Wistar Albino rats were randomly allocated into 7 groups. Nicotine (2 mg/kg/day) was intraperitoneally introduced to these rats in 6 groups before, during and after pregnancy, while the rat in the control group received isotonic saline intraperitoneally. Fourteen newborns delivered by each rat were sacrificed at the end of 9 weeks after being breastfed for 3 weeks after birth...
November 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27905982/the-use-of-a-lot-quality-assurance-sampling-methodology-to-assess-and-manage-primary-health-interventions-in-conflict-affected-west-darfur-sudan
#8
Kiemanh Pham, Emily Chambers Sharpe, William M Weiss, Alexander Vu
BACKGROUND: Organizations working in conflict-affected areas have a need to monitor and evaluate their programs, however this is often difficult due to the logistical challenges of conflict areas. Lot quality assurance sampling may be a suitable method of assessing programs in these situations. METHODS: We conducted a secondary data analysis of information collected during Medair's routine program management functions. Medair's service area in West Darfur, Sudan was divided into seven supervisory areas...
October 6, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27904604/evaluating-the-role-of-maternal-folic-acid-supplementation-in-modifying-the-effects-of-methylenetetrahydrofolate-reductase-c677t-and-a1298c-gene-polymorphisms-in-oral-cleft-children
#9
Asghar Ebadifar, Nazila Ameli, Hamid Reza KhorramKhorshid, Koorosh Kamali, Mehdi Salehi Zeinabadi
BACKGROUND: We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts. MATERIALS AND METHODS: Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotypes was analyzed...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27904516/serum-pregnancy-associated-plasma-protein-a-levels-in-the-first-second-and-third-trimester-of-pregnancy-relation-to-newborn-anthropometric-parameters-and-maternal-tobacco-smoking
#10
Magdalena Chełchowska, Joanna Gajewska, Joanna Mazur, Jadwiga Ambroszkiewicz, Tomasz M Maciejewski, Jerzy Leibschang
INTRODUCTION: The purpose of this study was to evaluate the associations of the first, second and third trimester serum pregnancy-associated plasma protein A (PAPP-A) concentrations with neonatal anthropometric parameters. The effect of tobacco smoking during pregnancy on PAPP-A level was also studied. MATERIAL AND METHODS: One hundred and fifty healthy pregnant women were divided into smoking and tobacco-abstinent groups. Serum PAPP-A level was measured with the KRYPTOR rapid random-access immunoassay analyzer...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27900667/should-domperidone-be-used-as-a-galactagogue-possible-safety-implications-for-mother-and-child
#11
Luc M Hondeghem, Noël H Logghe
Domperidone has been used as a galactagogue; however, solid evidence from an adequate sized randomized clinical trial is missing. Optimal dosage, start of treatment, length of treatment and scope of patients who can benefit also remain unknown. Although milk obtained after domperidone administration has not been shown to have untoward effects on newborns, no sufficiently large randomized clinical trial has been done to establish safety. Domperidone has repeatedly been shown to produce sudden cardiac death, starting at 30 mg/day...
November 29, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27895847/efficacy-of-a-low-cost-bubble-cpap-system-in-treatment-of-respiratory-distress-in-a-neonatal-ward-in-malawi
#12
Kondwani Kawaza, Heather E Machen, Jocelyn Brown, Zondiwe Mwanza, Suzanne Iniguez, Al Gest, E O'Brian Smith, Maria Oden, Rebecca R Richards-Kortum, Elizabeth Molyneux
BACKGROUND: Respiratory failure is a leading cause of neonatal mortality in the developing world. Bubble continuous positive airway pressure (bCPAP) is a safe, effective intervention for infants with respiratory distress and is widely used in developed countries. Because of its high cost, bCPAP is not widely utilized in low-resource settings. We evaluated the performance of a new bCPAP system to treat severe respiratory distress in a low resource setting, comparing it to nasal oxygen therapy, the current standard of care...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27888816/opinions-about-vaccination-among-mothers-who-delivered-newborns-in-two-hospitals-in-krakow-and-my%C3%A5-lenice
#13
Dorota Mrożek-Budzyn, Agnieszka Kiełtyka, Elżbieta Mróz
INTRODUCTION AND OBJECTIVE: Campaigns against vaccinations in Poland have been increasingly more frequently observed in recent years, that was the reason of bigger number of parents refusing a consent for their children immunization. The aim of study was to determine the sources of information which significantly influence mothers’ opinions about vaccinations. MATERIALS AND METHODS: A survey was conducted among 154 randomly selected mothers hospitalized after childbearing in two hospitals in Krakow and Myslenice at the end of 2014 and in 2015...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27888742/serological-evidence-for-high-prevalence-of-influenza-d-viruses-in-cattle-nebraska-united-states-2003-2004
#14
Junrong Luo, Lucas Ferguson, David R Smith, Amelia R Woolums, William B Epperson, Xiu-Feng Wan
Influenza D virus (IDV), a new member of the influenza virus family, was first reported in 2011 in swine in Oklahoma, USA, and then soon found in cattle across North America and Eurasia. Earlier studies suggested cattle serve as natural reservoir for IDV. The goal of this study is to perform a retrospective study looking at sera collected from Nebraska beef herds in 2003-2004 and 2014 for evidence of IDV antibodies. Results showed that all 40 randomly selected farms (2003-2004) we tested contained IDV seropositive adult animals and that approximately 98% of newborn calves (2014) had high levels of maternal antibodies against IDV...
November 23, 2016: Virology
https://www.readbyqxmd.com/read/27886191/hemodynamic-and-metabolic-effects-of-a-new-pediatric-dobutamine-formulation-in-hypoxic-newborn-pigs
#15
Victoria E Mielgo, Adolf Valls-I-Soler, Juan M Lopez de Heredia, Heike Rabe, Carmen Rey-Santano
BACKGROUND: The aim of our study was to measure drug-related changes in hemodynamics and oxygen metabolism in response to different doses of an age-appropriate dobutamine formulation in hypoxic pigs. A secondary aim was to validate superior vena cava flow (SVCF) as a marker of cardiac index (CI) for subsequent clinical trials of this formulation in humans. METHODS: Newborn pigs (n=18) were exposed to 2h-hypoxia (10-15% oxygen) followed by reoxygenation (21-30% oxygen 4h)...
November 25, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27885658/early-skin-to-skin-contact-for-mothers-and-their-healthy-newborn-infants
#16
REVIEW
Elizabeth R Moore, Nils Bergman, Gene C Anderson, Nancy Medley
BACKGROUND: Mother-infant separation post birth is common. In standard hospital care, newborn infants are held wrapped or dressed in their mother's arms, placed in open cribs or under radiant warmers. Skin-to-skin contact (SSC) begins ideally at birth and should last continually until the end of the first breastfeeding. SSC involves placing the dried, naked baby prone on the mother's bare chest, often covered with a warm blanket. According to mammalian neuroscience, the intimate contact inherent in this place (habitat) evokes neuro-behaviors ensuring fulfillment of basic biological needs...
November 25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27882439/obstetric-and-perinatal-outcome-of-babies-born-from-sperm-selected-by-macs-from-a-randomized-controlled-trial
#17
Laura Romany, Nicolas Garrido, Ana Cobo, Belen Aparicio-Ruiz, Vicente Serra, Marcos Meseguer
PURPOSE: The purpose of this study is to assess outcomes after magnetic-activated cell sorting (MACS) technology on obstetric and perinatal outcomes compared with those achieved after swim up from randomized controlled trial. METHODS: This is a two-arm, unicentric, prospective, randomized, and triple-blinded trial and has a total of 237 infertile couples, between October 2010 and January 2013. A total of 65 and 66 newborns from MACS and control group, respectively, were described...
November 23, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27881297/a-randomized-controlled-clinical-trial-investigating-the-effects-of-omega-3-fatty-acids-and-vitamin-e-co-supplementation-on-biomarkers-of-oxidative-stress-inflammation-and-pregnancy-outcomes-in-gestational-diabetes
#18
Mehri Jamilian, Shahrzad Hashemi Dizaji, Fereshteh Bahmani, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Maryam Karamali, Maryam Akbari, Zatollah Asemi
OBJECTIVES: Limited data are available for assessing the effects of omega-3 fatty acids and vitamin E co-supplementation on metabolic profiles and pregnancy outcomes in gestational diabetes (GDM). This study was designed to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on biomarkers of oxidative stress, inflammation and pregnancy outcomes in women with GDM. METHODS: This randomized, double-blind, placebo-controlled clinical trial was conducted in 60 patients with GDM who were not taking oral hypoglycemic agents...
November 21, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27875703/prevalence-and-characterization-of-neonatal-skin-disorders-in-the-first-72h-of-life
#19
Flávia Pereira Reginatto, Damie DeVilla, Fernanda M Muller, Juliano Peruzzo, Letícia P Peres, Raquel B Steglich, Tania F Cestari
OBJECTIVE: To determine the prevalence of neonatal dermatological findings and analyze whether there is an association between these findings and neonatal and pregnancy characteristics and seasonality. METHODS: Newborns from three maternity hospitals in a Brazilian capital city were randomly selected to undergo dermatological assessment by dermatologists. RESULTS: 2938 neonates aged up to three days of life were randomly selected, of whom 309 were excluded due to Intensive Care Unit admission...
November 19, 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27866182/homeopathic-treatment-of-overweight-and-obesity-in-pregnant-women-with-mental-disorders-a-double-blind-controlled-clinical-trial
#20
Edgard Costa de Vilhena, Euclides Ayres de Castilho
Context • Worldwide, 35 million people suffer from obesity. Mental disorders have been associated with being overweight or obese. Considerable evidence has shown a correlation between stress and the use of homeopathy and stress and obesity. However, few studies have examined the relationship between weight loss and homeopathic treatment of obesity. Objective • The study intended to evaluate the efficacy of a homeopathic treatment in preventing excessive weight gain during pregnancy in overweight or obese women who were suspected of having a common mental disorder...
October 2016: Alternative Therapies in Health and Medicine
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