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Calcium acetate

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https://www.readbyqxmd.com/read/29921464/the-influence-of-precursor-addition-order-on-the-porosity-of-sol-gel-bioactive-glasses
#1
Delihta Fernando, Pierre Colon, Mark Cresswell, Catherine Journet, Nelly Pradelle-Plasse, Phil Jackson, Brigitte Grosgogeat, Nina Attik
OBJECTIVE: The superior textural properties of sol-gel derived bioactive glasses compared to conventional melt quench glasses accounts for their accelerated bioactivity in vitro. Several studies have explored ways to improve the surface properties of sol-gel glasses in order to maximise their efficiency for bone and tooth regeneration. In this study, we investigated the effect of order of network modifying precursor addition on the textural properties of sol-gel derived bioactive glasses...
June 16, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29921020/physico-chemical-factors-influencing-spore-germination-in-cyanobacterium-fischerella-muscicola
#2
Biranchi N Mishra, Manish S Kaushik, Gerard Abraham, Pawan K Singh
Spore (akinete) formation in the heterocystous and branched filamentous cyanobacterium Fischerella muscicola involves a significant increase in cell size and formation of several endospores in each of the cells. In present study, the physico-chemical factors (pH, light sources, nutrient deficiency, nitrogen sources, carbon sources, and growth hormones) affecting the germination of spores of F. muscicola were examined. Increase in spore germination frequency was detected above pH 8 with maximum germination (46...
June 19, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29909236/antiepileptic-drugs-as-analgesics-adjuvants-in-inflammatory-pain-current-preclinical-evidence
#3
REVIEW
Tomić Maja, Pecikoza Uroš, Micov Ana, Vučković Sonja, Stepanović-Petrović Radica
Inflammatory pain is the most common type of pain that is treated clinically. The use of currently available treatments (classic analgesics - NSAIDs, paracetamol and opioids) is limited by insufficient efficacy and/or side effects/tolerance development. Antiepileptic drugs (AEDs) are widely used in neuropathic pain treatment, but there is substantial preclinical evidence on their efficacy against inflammatory pain, too. In this review we focus on gabapentinoids (gabapentin and pregabalin) and dibenzazepine AEDs (carbamazepine, oxcarbazepine, and recently introduced eslicarbazepine acetate) and their potential for relieving inflammatory pain...
June 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29907056/calcium-ions-in-aqueous-solutions-accurate-force-field-description-aided-by-ab-initio-molecular-dynamics-and-neutron-scattering
#4
Tomas Martinek, Elise Duboué-Dijon, Štěpán Timr, Philip E Mason, Katarina Baxová, Henry E Fischer, Burkhard Schmidt, Eva Pluhařová, Pavel Jungwirth
We present a combination of force field and ab initio molecular dynamics simulations together with neutron scattering experiments with isotopic substitution that aim at characterizing ion hydration and pairing in aqueous calcium chloride and formate/acetate solutions. Benchmarking against neutron scattering data on concentrated solutions together with ion pairing free energy profiles from ab initio molecular dynamics allows us to develop an accurate calcium force field which accounts in a mean-field way for electronic polarization effects via charge rescaling...
June 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29860419/acetate-free-citrate-acidified-bicarbonate-dialysis-improves-serum-calcification-propensity-a-preliminary-study
#5
Georg Lorenz, Christopher C Mayer, Quirin Bachmann, Sarah Stryeck, Matthias C Braunisch, Bernhard Haller, Javier Carbajo-Lozoya, Alina Schmidt, Simon Witthauer, Jasmin Abuzahu, Stephan Kemmner, Susanne Angermann, Naresh Koneru, Siegfried Wassertheurer, Richard Bieber, Uwe Heemann, Tobias Madl, Andreas Pasch, Christoph Schmaderer
Background: A novel in vitro test (T50 test) assesses ex vivo serum calcification propensity and predicts mortality in chronic kidney disease and haemodialysis (HD) patients. For the latter, a time-dependent decline of T50 was shown to relate to mortality. Here we assessed whether a 3-month switch to acetate-free, citrate-acidified, standard bicarbonate HD (CiaHD) sustainably improves calcification propensity. Methods: T50 values were assessed in paired midweek pre-dialysis sera collected before and 3 months after CiaHD in 78 prevalent European HD patients...
May 30, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29859330/biochemical-characterization-of-the-skeletal-matrix-of-the-massive-coral-porites-australiensis-the-saccharide-moieties-and-their-localization
#6
Takeshi Takeuchi, Laurent Plasseraud, Isabelle Ziegler-Devin, Nicolas Brosse, Chuya Shinzato, Noriyuki Satoh, Frédéric Marin
To construct calcium carbonate skeletons of sophisticated architecture, scleractinian corals secrete an extracellular skeletal organic matrix (SOM) from aboral ectodermal cells. The SOM, which is composed of proteins, saccharides, and lipids, performs functions critical for skeleton formation. Even though polysaccharides constitute the major component of the SOM, its contribution to coral skeleton formation is poorly understood. To this end, we analyzed the SOM of the massive colonial coral, Porites australiensis, the skeleton of which has drawn great research interest because it records environmental conditions throughout the life of the colony...
May 30, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/29852462/source-and-chemical-species-characterization-of-pm-10-and-human-health-risk-assessment-of-semi-urban-urban-and-industrial-areas-of-west-bengal-india
#7
Suraj Ghosh, Rumi Rabha, Mallika Chowdhury, Pratap Kumar Padhy
Levels of particulate matter of size ten micron (PM10 ) in outdoor air, potential PM10 -bound seven metals - manganese, zinc, cadmium, lead, copper, nickel and cobalt - and twelve water-soluble organic and inorganic ionic components - fluoride, acetate, chloride, nitrite, bromide, nitrate, phosphate, sulfate, oxalate, sodium, potassium and calcium - were investigated during two different season. Atmospheric PM10 samples were collected concurrently from three different sites, i.e., Durgapur (Industrial), Berhampore (Urban) and Bolpur (Semi-urban), West Bengal, India, during summer (April-June 2014) and winter (December 2014-February 2015)...
May 23, 2018: Chemosphere
https://www.readbyqxmd.com/read/29804111/validation-of-a-real-time-ise-methodology-to-quantify-the-influence-of-inhibitors-of-demineralization-kinetics-in-vitro-using-a-hydroxyapatite-model-system
#8
Wei-Te Huang, Saroash Shahid, Paul Anderson
The aim was to validate a novel protocol to measure the cariostatic efficacies of demineralization inhibitors by repeating previous SMR (scanning microradiography) studies investigating the dose response of Zn2+ and F- on demineralization kinetics in vitro using real-time Ca2+ ion selective electrodes (ISEs). In this study, Ca2+ release was used as a proxy for the extent of demineralization. Forty-eight hydroxyapatite (HAP) discs were allocated into 16 groups (n = 3) and adding either increasing [Zn2+], or [F-], similar to those used in the previous SMR studies...
May 25, 2018: Caries Research
https://www.readbyqxmd.com/read/29799304/aggregation-is-impaired-in-starved-platelets-due-to-enhanced-autophagy-and-cellular-energy-depletion
#9
Manoj Paul, Mahadevappa Hemshekhar, Kempaiah Kemparaju, Kesturu S Girish
Platelet hyperactivity is the hallmark of thrombosis and hemostasis disorders including atherosclerosis, diabetes, stroke, arthritis, and cancer causing significant mortality and morbidity. Therefore, regulating platelet hyperactivity is an ever growing interest. Very recently, basal autophagic process has been demonstrated to be essential for normal functioning of platelets. However, autophagy can be elevated above basal level under conditions like starvation, and how platelets respond in these settings remains to be elucidative...
May 25, 2018: Platelets
https://www.readbyqxmd.com/read/29783873/current-and-potential-treatment-options-for-hyperphosphatemia
#10
Fabio Carfagna, Lucia Del Vecchio, Giuseppe Pontoriero, Francesco Locatelli
Hyperphosphatemia is common in late stages of chronic kidney disease and is often associated with elevated parathormone levels, abnormal bone mineralization, extra-osseous calcification, and increased risk of cardiovascular events and death. Several classes of oral phosphate binders are available to help control plasma phosphorus levels. Although effective at lowering serum phosphorus, they all have safety, tolerability, and compliance issues that need to be considered when selecting which one to use. Areas covered: This paper reviews the most established treatment options for hyperphosphatemia, in patients with chronic kidney disease, focusing on the new inhibitors of active phosphate absorption...
May 21, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29751530/effect-of-dc-plasma-electrolytic-oxidation-on-surface-characteristics-and-corrosion-resistance-of-zirconium
#11
Maciej Sowa, Wojciech Simka
Zr is a valve metal, the biocompatibility of which is at least on par with Ti. Recently, numerous attempts of the formation of bioactive coatings on Zr by plasma electrolytic oxidation (PEO) in solutions that were based on calcium acetate and calcium β-glycerophosphate were made. In this study, the direct current (DC) PEO of commercially pure zirconium in the solutions that contained Ca(H₂PO₂)₂, Ca(HCOO)₂, and Mg(CH₃COO)₂ was investigated. The treatment was conducted at 75 mA/cm² up to 200, 300, or 400 V...
May 3, 2018: Materials
https://www.readbyqxmd.com/read/29748238/mir-302e-attenuates-allergic-inflammation-in-vitro-model-by-targeting-rela
#12
Lifeng Xiao, Li Jiang, Qi Hu, Yuru Li
Allergic inflammation is the foundation of allergic rhinitis and asthma. Although microRNAs are implicated in the pathogenesis of various diseases, information regarding the functional role of microRNAs in allergic diseases is limited. Herein, we reported that microRNA-302e (miR-302e) serves as an important regulator of allergic inflammation in human mast cell line, HMC-1 cells. Our results showed that miR-302e is the dominant member of miR-302 family expressed in HMC-1 cells. Moreover, the expression of miR-302e was significantly decreased in response to phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 or ovalbumin (OVA) stimulation...
May 10, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29740803/du-zhong-eucommia-ulmoides-oliv-cortex-extract-alleviates-lead-acetate-induced-bone-loss-in-rats
#13
Shanshan Qi, Hongxing Zheng, Chen Chen, Hai Jiang
The purpose of this study was to evaluate the protective effect of Du-Zhong cortex extract (DZCE) on lead acetate-induced bone loss in rats. Forty female Sprague-Dawley rats were randomly divided into four groups: group I (control) was provided with distilled water. Group II (PbAc) received 500 ppm lead acetate in drinking water for 60 days. Group III (PbAc+DZCE) received 500 ppm lead acetate in drinking water, and given intragastric DZCE (100 mg/kg body weight) for 60 days. Group IV (DZCE) was given intragastric DZCE (100 mg/kg body weight) for 60 days...
May 9, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29706452/comparative-effects-of-meso-2-3-dimercaptosuccinic-acid-monensin-and-salinomycin-on-the-concentrations-of-cadmium-and-some-essential-elements-in-skeletal-muscles-of-cd-exposed-mice
#14
Yordanka Gluhcheva, Kalina Kamenova, Petar Dorkov, Yulia Lobanova, Margarita Skalnaya, Juliana Ivanova
Cadmium (Cd) is an environmental pollutant shown to induce multi organ dysfunction. In this study we present novel data about the effects of meso-2,3-dimercaptosuccinic acid (DMSA), monensin and salinomycin on the concentration of Cd in skeletal muscles of mice exposed to Cd (II) acetate treatment for 14 days. The impact of Cd and the chelating agents on the endogenous concentrations of calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), phosphorous (P), selenium (Se) and zinc (Zn) was also investigated. Subacute exposure of mice to Cd (II) acetate resulted in a significant accumulation of the toxic metal ion in the skeletal muscles compared to the untreated controls...
April 20, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29655675/eupatilin-suppresses-the-allergic-inflammatory-response-in-vitro-and-in-vivo
#15
Eun-Hye Song, Kyung-Sook Chung, Yun-Mi Kang, Jong-Hyun Lee, Minho Lee, Hyo-Jin An
INTRODUCTION: Eupatilin, a pharmacologically active ingredient found in Artemisia asiatica, has been reported to have anti-oxidative, anti-inflammatory, and anti-apoptotic activities. However, molecular mechanisms underlying its anti-allergic properties are not yet clear. In this study, we investigated the effects of eupatilin on allergic inflammation in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells and a compound 48/80-induced anaphylactic shock model...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29628252/processing-and-antibacterial-properties-of-chitosan-coated-alginate-fibers
#16
Mélanie Dumont, Régis Villet, Manon Guirand, Alexandra Montembault, Thierry Delair, Stéphane Lack, Michel Barikosky, Agnès Crepet, Pierre Alcouffe, Frédéric Laurent, Laurent David
The preparation of chitosan-coated alginate fibers by a wet spin process is presented and the characterization of the antibacterial activities of these fibers is discussed. Preformed calcium alginate fibers were passed in chitosan acetate solutions. The coagulation method of the coating consisted in the immersion of fibers in a bath of calcium dihydroxide solution (0.1 M). The antibacterial evaluation was achieved by a CFU (Colony-Forming Units) counting method after 6 h of incubation at 37 °C. The incorporation of chitosan on calcium alginate fibers brings antibacterial activities against Staphylococcus epidermidis, Escherichia coli and various Staphylococcus aureus strains namely MSSA (Methicillin Sensitive Staphylococcus aureus), CA-MRSA (Community Associated Methicillin Resistant Staphylococcus aureus) and HA-MRSA (Healthcare Associated Methicillin Resistant Staphylococcus aureus) which make these chitosan-coated fibers potential candidates for wound dressing materials...
June 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29627829/effect-of-lanthanum-carbonate-on-all-cause-mortality-in-patients-receiving-maintenance-hemodialysis-a-meta-analysis-of-randomized-controlled-trials
#17
Fang Wang, Xiangxue Lu, Jingli Zhang, Ruifang Xiong, Han Li, Shixiang Wang
BACKGROUND/AIMS: Hyperphosphatemia is common in patients on hemodialysis. The efficacy of lanthanum carbonate (LC) in the treatment of hyperphosphatemia in these patients remains controversial. The objective of this meta-analysis was to evaluate the effect of LC on all-cause mortality in patients on maintenance hemodialysis. METHODS: We electronically searched the PubMed, EMBASE, and Cochrane Library databases for all randomized controlled trials (RCTs) comparing LC with other phosphate binders used in adult hemodialysis patients, including calcium carbonate, calcium acetate, and sevelamer...
2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29621577/six-months-exposure-to-a-real-life-mixture-of-13-chemicals-below-individual-noaels-induced-non-monotonic-sex-dependent-biochemical-and-redox-status-changes-in-rats
#18
Anca Oana Docea, Eliza Gofita, Marina Goumenou, Daniela Calina, Otilia Rogoveanu, Marius Varut, Cristian Olaru, Efthalia Kerasioti, Polyxeni Fountoucidou, Ioannis Taitzoglou, Ovidiu Zlatian, Valerii N Rakitskii, Antonio F Hernandez, Dimitrios Kouretas, Aristidis Tsatsakis
This study assessed the potential adverse health effects of long-term low-dose exposure to chemical mixtures simulating complex real-life human exposures. Four groups of Sprague Dawley rats were administered mixtures containing carbaryl, dimethoate, glyphosate, methomyl, methyl parathion, triadimefon, aspartame, sodium benzoate, calcium disodium ethylene diamine tetra-acetate, ethylparaben, butylparaben, bisphenol A, and acacia gum at doses of 0, 0.25, 1 or 5 times the respective Toxicological Reference Values (TRV): acceptable daily intake (ADI) or tolerable daily intake (TDI) in a 24 weeks toxicity study...
May 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29605258/induced-macrophage-activation-in-live-excised-atherosclerotic-plaque
#19
Hannah Prebble, Sean Cross, Edward Marks, Joe Healy, Emily Searle, Raja Aamir, Anthony Butler, Justin Roake, Barry Hock, Nigel Anderson, Steven P Gieseg
Atherosclerotic plaques are complex tissues containing many different cell types. Macrophages contribute to inflammation, formation of the necrotic core, and plaque rupture. We examined whether macrophages in plaque can be activated and compared this to monolayer cells. The volume of calcium in the plaque was compared to the level of macrophage activation measured by total neopterin output. Carotid plaque samples were cut into 3 mm sections and cultured for up to 96 h. Live sections were stimulated with interferon-γ, phytohaemagglutinin or phorbol 12-myristate 13-acetate...
March 23, 2018: Immunobiology
https://www.readbyqxmd.com/read/29604269/fisetin-inhibits-il-31-production-in-stimulated-human-mast-cells-possibilities-of-fisetin-being-exploited-to-treat-histamine-independent-pruritus
#20
Denis Nchang Che, Byoung Ok Cho, Jae Young Shin, Hyun Ju Kang, Young-Soo Kim, Seon Il Jang
Interleukin-31 (IL-31) is a recently discovered cytokine that is tightly linked to the pathogenesis of pruritus seen in atopic dermatitis. Flavonoids, like fisetin, are naturally occurring molecules with antioxidant, cytoprotective, and anti-inflammatory actions. AIM: the present study sought to investigate whether fisetin modulates IL-31 and histamine release in human mast cells (HMC-1). MAIN METHODS: HMC-1 cells were pretreated with fisetin at various doses and stimulated with phorbol-12-myristate 13-acetate and calcium ionophore A23187 (PI) for different time intervals...
May 15, 2018: Life Sciences
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