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Calcium acetate

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https://www.readbyqxmd.com/read/28724254/effects-of-calcium-on-the-performance-bacterial-population-and-microbial-metabolism-of-a-denitrifying-phosphorus-removal-system
#1
Hongliang Dai, Yifeng Wu, Lihong Peng, Zheqin Dai, Xiang Li, Xiwu Lu
A sequencing batch reactor was operated to study the effects of influent Ca(2+) on the efficiency, bacterial population, and microbial metabolism of denitrifying phosphorus removal system. Results showed that high Ca(2+) loading (≥80mg/L) significantly inhibited the performance of simultaneous nitrogen and phosphorus removal. The abundance of phosphorus removal-related organisms (Dechloromonas and Candidatus Accumulibacter) decreased with increasing Ca(2+) concentration from 20 to 140mg/L, while the abundance of glycogen-accumulating organisms and other bacteria increased...
July 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28712890/amburana-cearensis-seed-extract-protects-brain-mitochondria-from-oxidative-stress-and-cerebellar-cells-from-excitotoxicity-induced-by-glutamate
#2
E P L Pereira, C S Santos, J Amparo, R Short, Y Nuñez-Figueredo, L G Fernandez, P R Ribeiro, S Braga-de-Souza, V D A Silva, S L Costa
ETHNOPHARMACOLOGICAL RELEVANCE: Amburana cearensis (Allemao) A.C.Sm. is a medicinal plant of the Brazilian Caatinga reported to present antioxidant and anti-inflammatory activity. This study aimed to evaluate the neuroprotective effect of the extracts obtained from the seeds of A. cearensis in primary cultures of cerebellar cells subjected to excitotoxicity induced by glutamate and brain mitochondria submitted to oxidative stress. MATERIALS: and methods: Primary cultures of cerebellar cells were treated with the ethanol (ETAC), hexane (EHAC), dichloromethane (EDAC) and ethyl acetate (EAAC) extracts of the seeds of A...
July 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28701639/synthesized-mesoporous-silica-and-calcium-aluminate-cement-fillers-increased-the-fluoride-recharge-and-lactic-acid-neutralizing-ability-of-a-resin-based-pit-and-fissure-sealant
#3
Atikom Surintanasarn, Krisana Siralertmukul, Niyom Thamrongananskul
This study evaluated the effect of different types of filler in a resin-based pit and fissure sealant on fluoride release, recharge, and lactic acid neutralization. Resin-based sealant was incorporated with 5% w/w of the following fillers: calcium aluminate cement (CAC), synthesized mesoporous silica (SI), a CAC and SI mixture (CAC+SI), glass-ionomer powder (GIC), and acetic acid-treated GIC (GICA). Sealant without filler served as control. The samples were immersed in deionized water or a lactic acid solution and the concentration of fluoride in the water, before and after fluoride recharge, and the lactic acid pH change, respectively, were determined...
July 12, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28694089/the-potential-protective-role-of-taurine-against-experimental-allergic-inflammation
#4
Sun-Young Nam, Hyung-Min Kim, Hyun-Ja Jeong
AIMS: Taurine has been widely evaluated as a potential therapeutic agent in chronic inflammatory disorders and various infections. However, the potential role of taurine in regulating allergic inflammatory responses is currently unknown. MATERIALS AND METHODS: The present study was designed to evaluate the in vitro effects of taurine on the levels of thymic stromal lymphopoietin (TSLP) and other pro-inflammatory cytokines and activation of caspase-1 and nuclear factor (NF)-κB as well as the phosphorylations of c-Jun N-terminal kinase (JNK) and p38 in phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-triggered human mast cell line, HMC-1 cells...
July 7, 2017: Life Sciences
https://www.readbyqxmd.com/read/28688948/kondogogu-gum-zn-2-pectinate-emulgel-matrices-reinforced-with-mesoporous-silica-for-intragastric-furbiprofen-delivery
#5
Hriday Bera, Jhansirani Nadimpalli, Sanoj Kumar, Pavani Vengala
Flurbiprofen (FLU), a non-steroidal anti-inflammatory drug, exhibits limited clinical response due to its poor physicochemical properties. This study aimed at developing reliable drug carriers for intrgastric FLU delivery with a view to improve biopharmaceutical characteristics of drug and modulate its release in a controlled manner. In this context, FLU-loaded kondogogu gum (KG)-Zn(+2)-low methoxyl (LM) pectinate emulgel matrices reinforced with calcium silicate (CS) were accomplished by ionotropic gelation technique employing zinc acetate as cross-linker and characterized for their in vitro performances...
July 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28679150/microarray-based-bioinformatics-analysis-of-the-combined-effects-of-sinps-and-pbac-on-cardiovascular-system-in-zebrafish
#6
Hejing Hu, Yannan Zhang, Yanfeng Shi, Lin Feng, Junchao Duan, Zhiwei Sun
With rapid development of nanotechnology and growing environmental pollution, the combined toxic effects of SiNPs and pollutants of heavy metals like lead have received global attentions. The aim of this study was to explore the cardiovascular effects of the co-exposure of SiNPs and lead acetate (PbAc) in zebrafish using microarray and bioinformatics analysis. Although there was no other obvious cardiovascular malformation except bleeding phenotype, bradycardia, angiogenesis inhibition and declined cardiac output in zebrafish co-exposed of SiNPs and PbAc at NOAEL level, significant changes were observed in mRNA and microRNA (miRNA) expression patterns...
June 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28676270/synthesis-of-novel-2-pyrazoline-analogues-with-potent-anti-inflammatory-effect-mediated-by-inhibition-of-phospholipase-a2-crystallographic-in-silico-docking-and-qsar-analysis
#7
Devirammanahalli Mahadevaswamy Lokeshwari, Dileep Kumar Achutha, Bharath Srinivasan, Naveen Shivalingegowda, Lokanath Neratur Krishnappagowda, Ajay Kumar Kariyappa
Oxidative-stress induces inflammatory diseases. Further, infections caused by drug-resistant microbial strains are on the rise. This necessitates the discovery of novel small-molecules for intervention therapy. A series of 3-(2,3-dichlorophenyl)-1-(aryl)prop-2-en-1-ones are synthesized as intermediates via Claisen-Schmidt reaction approach. Subsequently, these intermediates were transformed into 2-pyrazolines by their reaction with phenylhydrazine hydrochlorides in methanol and few drops of acetic acid under reflux conditions...
June 24, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28675318/immunomodulatory-and-antioxidant-protective-effect-of-sarcocornia-perennis-l-swampfire-in-lead-intoxicated-rat
#8
Manel Gargouri, Houda Hamed, Amel Akrouti, Christian Magné, Riadh Ksouri, Abdelfattah El Feki
Lead (Pb) is a very toxic metal present in the environment, causing disturbances of several functions. Preventive or curative effects of halophytic plants against these disorders may be a promising and safe therapeutic strategy. Thus, this study was designed to evaluate in vivo immunomodulatory and antioxidant effects of Sarcocornia perennis extract (Sp) against lead toxicity in rats. Groups of six animals each were treated with plant extract (via food), 6 g/L lead acetate (via drinking water) or a combination of both...
July 4, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28670618/minute-impurities-contribute-significantly-to-olfactory-receptor-ligand-studies-tales-from-testing-the-vibration-theory
#9
M Paoli, D Münch, A Haase, E Skoulakis, L Turin, C G Galizia
Several studies have attempted to test the vibrational hypothesis of odorant receptor activation in behavioral and physiological studies using deuterated compounds as odorants. The results have been mixed. Here, we attempted to test how deuterated compounds activate odorant receptors using calcium imaging of the fruit fly antennal lobe. We found specific activation of one area of the antennal lobe corresponding to inputs from a specific receptor. However, upon more detailed analysis, we discovered that an impurity of 0...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28639010/modulation-of-calcium-carbonate-precipitation-by-exopolysaccharide-in-bacillus-sp-jh7
#10
Hyun Jung Kim, Bora Shin, Yun Suk Lee, Woojun Park
Extracellular polymeric substance (EPS) is proposed to facilitate calcium ion supersaturation through its nucleation effect during the microbially induced calcium carbonate precipitation (MICP) process. However, the supersaturation effect of Ca(2+) via EPS in MICP has not been clearly demonstrated. Enhanced exopolysaccharide production of the alkali- and halotolerant MICP-capable bacteria, Bacillus sp. JH7, was achieved through glycerol addition. This was demonstrated by measuring cellular precipitation and Congo red binding...
June 22, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28616734/di-2-pyridylketone-4-4-dimethyl-3-thiosemicarbazone-dp44mt-an-anticancer-agent-exerts-an-anti-inflammatory-effect-in-activated-human-mast-cells
#11
Sun-Young Nam, Na-Ra Han, Kyoung Wan Yoon, Hyung-Min Kim, Hyun-Ja Jeong
OBJECTIVE: Inflammation has been closely associated with the development and progression of cancer. Previously, we reported that mast cells play a critical role in tumor growth. The purpose of this study is to investigate the anti-inflammatory effect of an anticancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), on an activated human mast cell line, in this case HMC-1 cells. METHODS: We evaluated the effect and specific molecular mechanism of Dp44mT on phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI) using HMC-1 cells...
June 14, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28614613/population-pharmacokinetic-and-exposure-response-analysis-of-weekly-teriparatide-in-osteoporosis-patients
#12
Atsushi Ose, Masashi Serada, Keiko Yamashita, Kazuyuki Tsurui, Yusuke Tanigawara
Teriparatide is a potent therapeutic agent for the treatment of osteoporosis. One of the aims of this analysis was to develop a population pharmacokinetic (PPK) model to understand the pharmacokinetic characteristics of the once-weekly formulation of teriparatide. Another aim was to develop an exposure-response model to describe the relationship between change in bone mineral density (BMD) and teriparatide exposure after weekly subcutaneous administration. The PPK analysis showed that apparent total body clearance was significantly influenced by estimated creatinine clearance and the presence of osteoporosis...
June 14, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28598364/isoprenoids-production-from-lipid-extracted-microalgal-biomass-residues-using-engineered-e-coli
#13
Sumeng Wang, Jianming Yang
Microalgae are recognized as a third generation feedstock for biofuel production due to their rapid growth rates and lignin-free characteristics. In this study, a lipid extracted microalgal biomass residues was used as the raw material to produce isoprene, α-pinene and β-pinene with an engineered E. coli strain. We adopted an optimal sulfuric acid hydrolysis method (1:7 ratio of solid to acid solution, 32% (w/v) concentration of sulfuric acid solution at 90 °C for 90 min) to efficiently convert holocellulose into glucose efficiently (6...
June 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28585818/oxidation-of-secondary-methyl-ethers-to-ketones
#14
Pieter J Gilissen, Daniel Blanco-Ania, Floris P J T Rutjes
We present a mild way of converting secondary methyl ethers into ketones using calcium hypochlorite in aqueous acetonitrile with acetic acid as activator. The reaction is compatible with various oxygen- and nitrogen-containing functional groups and afforded the corresponding ketones in up to 98% yield. The use of this methodology could expand the application of the methyl group as a useful protecting group.
July 7, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28584909/a-review-of-phosphate-binders-in-chronic-kidney-disease-incremental-progress-or-just-higher-costs
#15
REVIEW
Wendy L St Peter, Lori D Wazny, Eric Weinhandl, Katie E Cardone, Joanna Q Hudson
As kidney disease progresses, phosphorus retention also increases, and phosphate binders are used to treat hyperphosphatemia. Clinicians prescribe phosphate binders thinking that reducing total body burden of phosphorus may decrease risks of mineral and bone disorder, fractures, cardiovascular disease, progression of kidney disease, and mortality. Recent meta-analyses suggest that sevelamer use results in lower mortality than use of calcium-containing phosphate binders. However, studies included in meta-analyses show significant heterogeneity, and exclusion or inclusion of specific studies alters results...
July 2017: Drugs
https://www.readbyqxmd.com/read/28578568/calcium-l-lactate-frameworks-as-naturally-degradable-carriers-for-pesticides
#16
Jingjing Yang, Christopher A Trickett, Salman B Alahmadi, Ahmad S Alshammari, Omar M Yaghi
Two porous, chiral metal-organic frameworks (MOFs), Ca14(l-lactate)20(acetate)8(C2H5OH)(H2O) (MOF-1201) and Ca6(l-lactate)3(acetate)9(H2O) (MOF-1203), are constructed from Ca(2+) ions and l-lactate [CH3CH(OH)COO(-)], where Ca(2+) ions are bridged by the carboxylate and hydroxyl groups of lactate and the carboxylate group of acetate to give a three-dimensional arrangement of Ca(-COO, -OH) polyhedra supporting one-dimensional pores with apertures and internal diameters of 7.8 and 9.6 Å (MOF-1201) and 4.6 and 5...
June 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28572961/development-and-evaluation-of-floating-alginate-microspheres-for-oral-delivery-of-anthocyanins-a-preliminary-investigation
#17
Giovana B Celli, Amyl Ghanem, Marianne S Brooks
The goal of this study was to develop floating microspheres that could be used as gastroretentive systems for the delivery of anthocyanins (ACNs). These compounds are absorbed in the stomach and small intestine, and insufficient residence time in these organs could result in limited absorption and contribute to degradation. The microparticles containing freeze-dried haskap berry extract (321.96 ± 8.35 mg cyanidin 3-glucoside equivalents per g) were prepared by ionotropic gelation of alginate (9%, w/w) with calcium ions (CaCl2 at 2%, w/v) in the gelation bath, with calcium carbonate as the gas-generating compound (added at different ratios in the alginate/extract mixture)...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28560646/synergistic-effect-of-chryseobacterium-gleum-sp-suk-with-acc-deaminase-activity-in-alleviation-of-salt-stress-and-plant-growth-promotion-in-triticum-aestivum-l
#18
Komal K Bhise, Prashant K Bhagwat, Padma Babulal Dandge
Soil salinity is major abiotic stresses affecting morphological, biochemical and physiological processes of plant growth. Chryseobacterium gleum sp. SUK isolated from salt-stressed soil exhibited ACC (1-aminocyclopropane-1-carboxylate) deaminase activity with IAA (indole acetic acid), siderophore, ammonia, hydrogen cyanide production, 2% salt tolerance and fungal cell wall degrading enzyme production (cellulase, protease). The isolate also showed a poultry feather degrading activity which is the main waste material of poultry industry and opulent source of proteins, amino acids, nitrogen, phosphorous, calcium, potassium, manganese, zinc and copper...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28554984/the-effect-of-deoxycholic-acid-on-secretion-and-motility-in-the-rat-and-guinea-pig-large-intestine
#19
Nam Hee Kim, Jung Ho Park, Jae-Soon Park, Yeun-Ho Joung
Background/Aims: Bile acid is an important luminal factor that affects gastrointestinal motility and secretion. We investigated the effect of bile acid on secretion in the proximal and distal rat colon and coordination of bowel movements in the guinea pig colon. Methods: The short-circuit current from the mucosal strip of the proximal and distal rat colon was compared under control conditions after induction of secretion with deoxycholic acid (DCA) as well as after inhibition of secretion with indomethacin, 1,2-bis (o-aminophenoxy) ethane-N, N,N',N'-tetra-acetic acid (an intracellular calcium chelator; BAPTA), and tetrodotoxin (TTX) using an Ussing chamber...
May 29, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28544090/functional-tuning-of-the-catalytic-residue-pka-in-a-de-novo-designed-esterase
#20
Katharina Hiebler, Zsófia Lengyel, Carlos A Castañeda, Olga V Makhlynets
AlleyCatE is a de novo designed esterase that can be allosterically regulated by calcium ions. This artificial enzyme has been shown to hydrolyze p-nitrophenyl acetate (pNPA) and 4-nitrophenyl-(2-phenyl)-propanoate (pNPP) with high catalytic efficiency. AlleyCatE was created by introducing a single histidine residue (His(144) ) into a hydrophobic pocket of calmodulin. In this work, we explore the determinants of catalytic properties of AlleyCatE. We obtained the pKa value of the catalytic histidine using experimental measurements by NMR and pH rate profile and compared these values to those predicted from electrostatics pKa calculations (from both empirical and continuum electrostatics calculations)...
May 24, 2017: Proteins
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