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Calcium acetate

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https://www.readbyqxmd.com/read/29655675/eupatilin-suppresses-the-allergic-inflammatory-response-in-vitro-and-in-vivo
#1
Eun-Hye Song, Kyung-Sook Chung, Yun-Mi Kang, Jong-Hyun Lee, Minho Lee, Hyo-Jin An
INTRODUCTION: Eupatilin, a pharmacologically active ingredient found in Artemisia asiatica, has been reported to have anti-oxidative, anti-inflammatory, and anti-apoptotic activities. However, molecular mechanisms underlying its anti-allergic properties are not yet clear. In this study, we investigated the effects of eupatilin on allergic inflammation in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells and a compound 48/80-induced anaphylactic shock model...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29628252/processing-and-antibacterial-properties-of-chitosan-coated-alginate-fibers
#2
Mélanie Dumont, Régis Villet, Manon Guirand, Alexandra Montembault, Thierry Delair, Stéphane Lack, Michel Barikosky, Agnès Crepet, Pierre Alcouffe, Frédéric Laurent, Laurent David
The preparation of chitosan-coated alginate fibers by a wet spin process is presented and the characterization of the antibacterial activities of these fibers is discussed. Preformed calcium alginate fibers were passed in chitosan acetate solutions. The coagulation method of the coating consisted in the immersion of fibers in a bath of calcium dihydroxide solution (0.1 M). The antibacterial evaluation was achieved by a CFU (Colony-Forming Units) counting method after 6 h of incubation at 37 °C. The incorporation of chitosan on calcium alginate fibers brings antibacterial activities against Staphylococcus epidermidis, Escherichia coli and various Staphylococcus aureus strains namely MSSA (Methicillin Sensitive Staphylococcus aureus), CA-MRSA (Community Associated Methicillin Resistant Staphylococcus aureus) and HA-MRSA (Healthcare Associated Methicillin Resistant Staphylococcus aureus) which make these chitosan-coated fibers potential candidates for wound dressing materials...
June 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29627829/effect-of-lanthanum-carbonate-on-all-cause-mortality-in-patients-receiving-maintenance-hemodialysis-a-meta-analysis-of-randomized-controlled-trials
#3
Fang Wang, Xiangxue Lu, Jingli Zhang, Ruifang Xiong, Han Li, Shixiang Wang
BACKGROUND/AIMS: Hyperphosphatemia is common in patients on hemodialysis. The efficacy of lanthanum carbonate (LC) in the treatment of hyperphosphatemia in these patients remains controversial. The objective of this meta-analysis was to evaluate the effect of LC on all-cause mortality in patients on maintenance hemodialysis. METHODS: We electronically searched the PubMed, EMBASE, and Cochrane Library databases for all randomized controlled trials (RCTs) comparing LC with other phosphate binders used in adult hemodialysis patients, including calcium carbonate, calcium acetate, and sevelamer...
March 29, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29621577/six-months-exposure-to-a-real-life-mixture-of-13-chemicals-below-individual-noaels-induced-non-monotonic-sex-dependent-biochemical-and-redox-status-changes-in-rats
#4
Anca Oana Docea, Eliza Gofita, Marina Goumenou, Daniela Calina, Otilia Rogoveanu, Marius Varut, Cristian Olaru, Efthalia Kerasioti, Polyxeni Fountoucidou, Ioannis Taitzoglou, Ovidiu Zlatian, Valerii N Rakitskii, Antonio F Hernandez, Dimitrios Kouretas, Aristidis Tsatsakis
This study assessed the potential adverse health effects of long-term low-dose exposure to chemical mixtures simulating complex real-life human exposures. Four groups of Sprague Dawley rats were administered mixtures containing carbaryl, dimethoate, glyphosate, methomyl, methyl parathion, triadimefon, aspartame, sodium benzoate, calcium disodium ethylene diamine tetra-acetate, ethylparaben, butylparaben, bisphenol A, and acacia gum at doses of 0, 0.25, 1 or 5 times the respective Toxicological Reference Values (TRV): acceptable daily intake (ADI) or tolerable daily intake (TDI) in a 24 weeks toxicity study...
April 2, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29605258/induced-macrophage-activation-in-live-excised-atherosclerotic-plaque
#5
Hannah Prebble, Sean Cross, Edward Marks, Joe Healy, Emily Searle, Raja Aamir, Anthony Butler, Justin Roake, Barry Hock, Nigel Anderson, Steven P Gieseg
Atherosclerotic plaques are complex tissues containing many different cell types. Macrophages contribute to inflammation, formation of the necrotic core, and plaque rupture. We examined whether macrophages in plaque can be activated and compared this to monolayer cells. The volume of calcium in the plaque was compared to the level of macrophage activation measured by total neopterin output. Carotid plaque samples were cut into 3 mm sections and cultured for up to 96 h. Live sections were stimulated with interferon-γ, phytohaemagglutinin or phorbol 12-myristate 13-acetate...
March 23, 2018: Immunobiology
https://www.readbyqxmd.com/read/29604269/fisetin-inhibits-il-31-production-in-stimulated-human-mast-cells-possibilities-of-fisetin-being-exploited-to-treat-histamine-independent-pruritus
#6
Denis Nchang Che, Byoung Ok Cho, Jae Young Shin, Hyun Ju Kang, Young-Soo Kim, Seon Il Jang
Interleukin-31 (IL-31) is a recently discovered cytokine that is tightly linked to the pathogenesis of pruritus seen in atopic dermatitis. Flavonoids, like fisetin, are naturally occurring molecules with antioxidant, cytoprotective, and anti-inflammatory actions. AIM: the present study sought to investigate whether fisetin modulates IL-31 and histamine release in human mast cells (HMC-1). MAIN METHODS: HMC-1 cells were pretreated with fisetin at various doses and stimulated with phorbol-12-myristate 13-acetate and calcium ionophore A23187 (PI) for different time intervals...
March 28, 2018: Life Sciences
https://www.readbyqxmd.com/read/29601810/2-3-dihydroxy-5-methoxybiphenyl-suppresses-fmlp-induced-superoxide-anion-production-and-cathepsin-g-release-by-targeting-the-%C3%AE-subunit-of-g-protein-in-human-neutrophils
#7
Hsiang-Ruei Liao, Ih-Sheng Chen, Fu-Chao Liu, Shinn-Zhi Lin, Ching-Ping Tseng
This study investigates the effect and the underlying mechanism of 2',3-dihydroxy-5-methoxybiphenyl (RIR-2), a lignan extracted from the roots of Rhaphiolepis indica (L.) Lindl. ex Ker var. tashiroi Hayata ex Matsum. & Hayata (Rosaceae), on N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced respiratory burst and cathepsin G in human neutrophils. Signaling pathways regulated by RIR-2 which modulated fMLP-induced respiratory burst were evaluated by an interaction between β subunit of G-protein (Gβ) with downstream signaling induced by fMLP and by immunoblotting analysis of the downstream targets of Gβ-protein...
March 27, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29600137/heavy-metal-detectors-based-on-modified-ferrite-nanoparticles
#8
Urszula Klekotka, Ewelina Wińska, Elżbieta Zambrzycka-Szelewa, Dariusz Satuła, Beata Kalska-Szostko
In this work, we analyze artificial heavy-metal solutions with ferrite nanoparticles. Measurements of adsorption effectiveness of different kinds of particles, pure magnetite or magnetite doped with calcium, cobalt, manganese, or nickel ions, were carried out. A dependence of the adsorption efficiency on the composition of the inorganic core has been observed. Ferrites surfaces were modified by phthalic anhydride (PA), succinic anhydride (SA), acetic anhydride (AA), 3-phosphonopropionic acid (3-PPA), or 16-phosphohexadecanoic acid (16-PHDA) to compare the adsorption capability of the heavy metals Cd, Cu and Pb...
2018: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29593709/hypertonic-saline-suppresses-nadph-oxidase-dependent-neutrophil-extracellular-trap-formation-and-promotes-apoptosis
#9
Ajantha Nadesalingam, Jacky H K Chen, Armin Farahvash, Meraj A Khan
Tonicity of saline (NaCl) is important in regulating cellular functions and homeostasis. Hypertonic saline is administered to treat many inflammatory diseases, including cystic fibrosis. Excess neutrophil extracellular trap (NET) formation, or NETosis, is associated with many pathological conditions including chronic inflammation. Despite the known therapeutic benefits of hypertonic saline, its underlying mechanisms are not clearly understood. Therefore, we aimed to elucidate the effects of hypertonic saline in modulating NETosis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29593702/use-of-a-potential-probiotic-lactobacillus-plantarum-l7-for-the-preparation-of-a-rice-based-fermented-beverage
#10
Sib Sankar Giri, Shib Sankar Sen, Subrata Saha, Venkatachalam Sukumaran, Se Chang Park
This study aimed to isolate potential probiotic lactic acid bacteria from a traditional rice-based fermented beverage "bhaati jaanr" and to evaluate their role during preparation of the beverage. Among various isolates, Lactobacillus plantarum strain L7 exhibited satisfactory in vitro probiotic characteristics such as acid resistance and bile tolerance, cell surface hydrophobicity, auto-aggregation, antibiotic susceptibility, and antimicrobial activities. Therefore, performance of L7 as a starter culture in rice fermentation was determined during a 6-day rice fermentation study...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29593138/-milk-daily-products-and-bone-health-the-effect-of-lactulose-on-bone-health
#11
Yohei Sakai
Lactulose is a non-digestible oligosaccharide, consisting of galactose and fructose. Bifidobacteria in the large intestine assimilate and metabolize lactulose, which has not been degraded or absorbed by humans, and they subsequently proliferate. Predominant bifidobacteria release short chain fatty acids, such as acetic acid and lactic acid, into the intestinal tract by lactulose metabolization, which lowers the intraluminal pH. As a result, the calcium that has flowed into the large intestine without absorption in the small intestine is solubilized and absorbed in the large intestine...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/29571131/nuclear-magnetic-resonance-spectroscopy-as-a-tool-for-the-quantitative-analysis-of-water-and-ions-in-pharmaceuticals-example-of-heparin
#12
Yulia B Monakhova, Bernd W K Diehl
Heparin is a linear, highly sulfated glycosaminoglycan (GAG), which consists of repeating disaccharide units of β-d-glucuronic acid or α-l-iduronic acid and α-d-glucosamine. While robust analytical approaches exist for the characterization of organic composition of heparin preparations, there is a lack of methods for the simultaneous quantification of inorganic compounds (water, anions, cations) in this matrix. A nuclear magnetic resonance (NMR) spectrometric method for heparin characterization described in US Pharmacopeia was extended to simultaneous analysis of the inorganic ions (sodium, calcium, and chloride), acetate as well as water content...
March 15, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29565143/the-presence-of-inorganic-calcium-in-pediatric-parenteral-admixtures
#13
Dorota Watrobska-Swietlikowska, Agnieszka Szlagatys-Sidorkiewicz, Ronan MacLoughlin
INTRODUCTION: Newborn infants and small children require large amounts of calcium and phosphate in a low volume of solution which can increase the risk of precipitation of calcium phosphate. Calcium gluconate is the predominant calcium salt form employed in parenteral nutrition (PN) compounding due to its solubility profile with phosphate. Unfortunately, calcium gluconate contains higher levels of aluminum contamination than calcium chloride, resulting in an increased potential for aluminum toxicity in patients receiving traditional PN...
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29563790/development-of-liposomal-pemetrexed-for-enhanced-therapy-against-multidrug-resistance-mediated-by-abcc5-in-breast-cancer
#14
Fang Bai, You Yin, Ting Chen, Jihui Chen, Meixin Ge, Yunshu Lu, Fangyuan Xie, Jian Zhang, Kejin Wu, Yan Liu
Purpose: Breast cancer is the most common cancer among women. Pemetrexed, a new generation antifolate drug, is one of the primary treatments for breast cancer. However, multidrug resistance (MDR) in breast cancer greatly hampers the therapeutic efficacy of chemotherapies such as pemetrexed. Nanomedicine is emerging as a promising alternative technique to overcome cancer MDR. Thus, pemetrexed-loaded d-alpha tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS) liposomes (liposomal pemetrexed) were developed as a strategy to overcome MDR to pemetrexed in breast cancer...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29563324/binding-characteristics-and-analgesic-effects-of-mirogabalin-a-novel-ligand-for-the-%C3%AE-2-%C3%AE-subunit-of-voltage-gated-calcium-channels
#15
Yuki Domon, Naohisa Arakawa, Tatsuya Inoue, Fumihiko Matsuda, Makoto Takahashi, Naotoshi Yamamura, Kiyonori Kai, Yutaka Kitano
Mirogabalin ([(1 R ,5 S ,6 S )-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid), a novel ligand for the α2 δ subunit of voltage-gated calcium channels, is being developed to treat pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. In the present study, we investigated the in vitro binding characteristics and in vivo analgesic effects of mirogabalin, compared to those of pregabalin, a standard α2 δ ligand. Mirogabalin showed potent and selective binding affinities for the α2 δ subunits, while having no effects on 186 off-target proteins...
March 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29556070/vitamin-d-alleviates-lead-induced-renal-and-testicular-injuries-by-immunomodulatory-and-antioxidant-mechanisms-in-rats
#16
Mohammad A BaSalamah, Abdelghany Hassan Abdelghany, Mohamed El-Boshy, Jawwad Ahmad, Shakir Idris, Bassem Refaat
This study measured the effects of vitamin D (VD) supplementation on the underlying molecular pathways involved in renal and testicular damage induced by lead (Pb) toxicity. Thirty two adult male Wistar rats were divided equally into four groups that were treated individually or simultaneously, except the negative control, for four weeks with lead acetate in drinking water (1,000 mg/L) and/or intramuscular VD (1,000 IU/kg; 3 days/week). Pb toxicity markedly reduced serum VD and Ca2+ , induced substantial renal and testicular injuries with concomitant significant alterations in the expression of VD metabolising enzymes, its receptor and binding protein, and the calcium sensing receptor...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29554732/metal-loid-immobilization-in-soils-with-biochars-pyrolyzed-in-n-2-and-co-2-environments
#17
Avanthi Deshani Igalavithana, Xiao Yang, Hilda Rizkia Zahra, Filip M G Tack, Daniel C W Tsang, Eilhann E Kwon, Yong Sik Ok
Previous studies indicated that using CO2 as a reaction agent in the pyrolysis of biomass led to an enhanced generation of syngas via direct reaction between volatile organic carbons (VOCs) evolved from the thermal degradation of biomass and CO2 . In addition, the physico-chemical properties of biochar in CO2 were modified. In this current study, biochars generated from red pepper stalks in N2 and CO2 (RPS-N and RPS-C, respectively) were tested for their effects on the immobilization of Pb, Cd, Zn, and As in contaminated soils...
March 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29549816/down-regulation-of-catsper-1-and-catsper-2-genes-by-lead-and-mercury
#18
Sh Mohammadi, M Gholamin, M Mohammadi, A Mansouri, R Mahmoodian, S Attari, S M Kebriaei, B Zibaei, M Roshanaei, F Daneshvar, M Khandehro, M A Khodadadegan, A Delshad, F Mohammadzadeh, Mostafa Peyvandi, Majid Ghayour-Mobarhan, Shima Tavallaie, Samaneh Boroumand-Noughabi, Gordon A A Ferns
In the study of the expression of CatSper genes, consideration of the effects of environmental metal toxicity is very important. Therefore, in this study, the effects of lead acetate and mercury chloride exposure on expression of CatSper genes, sperm parameters, histology of testis and prooxidant antioxidant balance (PAB) values of serum were investigated. A total of 28 mice was divided into four groups. The control group did not receive injections. The sham group received normal saline intraperitoneally. Lead and mercury groups were injected 60 and 1...
March 8, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29546579/the-antidiabetic-drug-metformin-blunts-netosis-in-vitro-and-reduces-circulating-netosis-biomarkers-in-vivo
#19
Lisa Menegazzo, Valentina Scattolini, Roberta Cappellari, Benedetta Maria Bonora, Mattia Albiero, Mario Bortolozzi, Filippo Romanato, Giulio Ceolotto, Saula Vigili de Kreutzeberg, Angelo Avogaro, Gian Paolo Fadini
AIMS: Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme instrumental to anti-microbial defences, but also involved in tissue damage. We herein investigated whether the antidiabetic drug metformin protects against NETosis. METHODS: We measured NET components in the plasma of patients with pre-diabetes who were randomized to receive metformin or placebo for 2 months. To control for the effect on glucose, we also measured NET components in the plasma of patients with type 2 diabetes before and after treatment with insulin or dapagliflozin...
March 15, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29535732/the-mek1-2-erk-pathway-inhibits-type-i-ifn-production-in-plasmacytoid-dendritic-cells
#20
Vaclav Janovec, Besma Aouar, Albert Font-Haro, Tomas Hofman, Katerina Trejbalova, Jan Weber, Laurence Chaperot, Joel Plumas, Daniel Olive, Patrice Dubreuil, Jacques A Nunès, Ruzena Stranska, Ivan Hirsch
Recent studies have reported that the crosslinking of regulatory receptors (RRs), such as blood dendritic cell antigen 2 (BDCA-2) (CD303) or ILT7 (CD85g), of plasmacytoid dendritic cells (pDCs) efficiently suppresses the production of type I interferons (IFN-I, α/β/ω) and other cytokines in response to toll-like receptor 7 and 9 (TLR7/9) ligands. The exact mechanism of how this B cell receptor (BCR)-like signaling blocks TLR7/9-mediated IFN-I production is unknown. Here, we stimulated BCR-like signaling by ligation of RRs with BDCA-2 and ILT7 mAbs, hepatitis C virus particles, or BST2 expressing cells...
2018: Frontiers in Immunology
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