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Ferric citrate

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https://www.readbyqxmd.com/read/28894591/efficacy-of-oral-contrast-agents-for-upper-gastrointestinal-signal-suppression-in-mrcp-a-systematic-review-of-the-literature
#1
Anne Frisch, Thula C Walter, Bernd Hamm, Timm Denecke
BACKGROUND: Orally administered substances which suppress signals from gastrointestinal fluid can be used to enhance image quality in magnetic resonance cholangiopancreatography (MRCP). In daily practice, the available substances range from commercial products to regular viands such as fruit juices. PURPOSE: To provide an overview on the significance of and the substances used as gastrointestinal fluid signal suppressors in MRCP. MATERIAL AND METHODS: A systematic review of the existing literature was performed to evaluate the efficacy and efficiency of oral T2-signal suppressors in MRCP...
September 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28871946/-mechanism-for-the-inhibition-of-proliferation-and-promotion-of-apoptosis-in-huh7-5-cells-by-iron-overload
#2
Yuan Qin, Jing Wei, Yi Zhang, Ling Kang, Bibo Kang, Huanjun Shen, Xuyang Zheng, Yaning Wang, Zhansheng Jia, Ying Zhang
Objective To investigate the effect of iron overload on biological activity and apoptosis in Huh7.5 cells. Methods Huh7.5 cells were cultured in the medium supplemented with 50, 100, 200 μmol/L ferric ammonium citrate (FAC). Fluorescence microscopy was employed to determine cell iron load labeled by Phen Green FL; proliferation activity of Huh7.5 cells was evaluated by MTT assay; protein and mRNA levels of transferrin receptor (TfR1), TfR2, divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) in Huh7...
August 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28854238/elastic-network-model-of-learned-maintained-contacts-to-predict-protein-motion
#3
Ines Putz, Oliver Brock
We present a novel elastic network model, lmcENM, to determine protein motion even for localized functional motions that involve substantial changes in the protein's contact topology. Existing elastic network models assume that the contact topology remains unchanged throughout the motion and are thus most appropriate to simulate highly collective function-related movements. lmcENM uses machine learning to differentiate breaking from maintained contacts. We show that lmcENM accurately captures functional transitions unexplained by the classical ENM and three reference ENM variants, while preserving the simplicity of classical ENM...
2017: PloS One
https://www.readbyqxmd.com/read/28836584/iron-dysregulates-app-processing-accompanying-with-sapp%C3%AE-cellular-retention-and-%C3%AE-secretase-inhibition-in-rat-cortical-neurons
#4
Yu-Ting Chen, Wu-Yan Chen, Xiao-Tian Huang, Ye-Chun Xu, Hai-Yan Zhang
Amyloid precursor protein (APP) and iron both play pivotal roles in the central nervous system, but whether and how iron influences the processing of endogenous APP in neurons remain unclear. Here, we investigated the regulatory effects and underlying mechanisms of iron on non-amyloidogenic and amyloidogenic processing of APP in rat primary cortical neurons. Treatment of the neurons with ferric ammonium citrate (FAC, 100 μmol/L) markedly facilitated the non-amyloidogenic processing of APP, as evidenced by a robust increase in α-secretase-derived carboxy-terminal fragment α (CTFα)...
August 24, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28722332/functionalized-acupuncture-needle-as-surface-enhanced-resonance-raman-spectroscopy-sensor-for-rapid-and-sensitive-detection-of-dopamine-in-serum-and-cerebrospinal-fluid
#5
Liangbao Yang, Pan Li, Binbin Zhou, Xiaomin Cao, Xianghu Tang, Ling Hu, Jinhuai Liu
It is challenging to develop a robust sensor for simple and rapid operation and sensitive detection of neurotransmitter in complex specimen. In the present work, the ferric-citrate-functionalized Au nanoparticles [Au NPs/CA-Fe(III)] is utilized to develop a facile sensor based on Surface-enhanced Resonance Raman spectroscopy (SERRS) for sensitive detection of dopamine (DA). The sensor is prepared by decorating acupuncture needle with Au NPs, which enables the sufficient SERS enhancement. CA-Fe(III) structure was highly sensitive and selective to DA with formation of CA-Fe(III)-DA resonant structure, indicating the advantages of capturing, carrying and separating DA molecules from complicated samples with simple operation...
July 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28642302/residual-erythropoiesis-protects-against-myocardial-hemosiderosis-in-transfusion-dependent-thalassemia-by-lowering-labile-plasma-iron-via-transient-generation-of-apotransferrin
#6
Maciej W Garbowski, Patricia Evans, Evangelia Vlachodimitropoulou, Robert Hider, John B Porter
Cardiosiderosis is a leading cause of mortality in transfusion-dependent thalassemias. Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis. Risk factors were identified in 73 patients with or without cardiosiderosis. Soluble transferrin receptor-1 levels were significantly lower in patients with cardiosiderosis (odds ratio 21). This risk increased when transfusion-iron loading rates exceeded the erythroid transferrin uptake rate (derived from soluble transferrin receptor-1) by >0...
June 22, 2017: Haematologica
https://www.readbyqxmd.com/read/28632119/alkaliphilus-namsaraevii-sp-nov-an-alkaliphilic-iron-and-sulfur-reducing-bacterium-isolated-from-a-steppe-soda-lake
#7
Anastasiya Zakharyuk, Lyudmila Kozyreva, Elena Ariskina, Olga Troshina, Dmitry Kopitsyn, Viktoria Shcherbakova
A novel alkaliphilic spore-forming bacterium was isolated from the benthic sediments of the highly mineralized steppe Lake Khilganta (Transbaikal Region, Russia). Cells of the strain, designated Х-07-2T, were straight to slightly curved rods, Gram-stain-positive and motile. Strain Х-07-2T grew in the pH range from 7.0 to 10.7 (optimum pH 9.6-10.3). Growth was observed at 25-47 °C (optimum 30 °C) and at an NaCl concentration from 5 to 150 g l-1 with an optimum at 40 g l-1. Strain Х-07-2T was a chemo-organoheterotroph able to reduce amorphous ferric hydroxide, Fe(III) citrate and elemental sulfur in the presence of yeast extract as the electron donor...
June 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28610916/the-rhizoferrin-biosynthetic-gene-in-the-fungal-pathogen-rhizopus-delemar-is-a-novel-member-of-the-nis-gene-family
#8
Cassandra S Carroll, Clark L Grieve, Indu Murugathasan, Andrew J Bennet, Clarissa M Czekster, Huanting Liu, James Naismith, Margo M Moore
Iron is essential for growth and in low iron environments such as serum many bacteria and fungi secrete ferric iron-chelating molecules called siderophores. All fungi produce hydroxamate siderophores with the exception of Mucorales fungi, which secrete rhizoferrin, a polycarboxylate siderophore. Here we investigated the biosynthesis of rhizoferrin by the opportunistic human pathogen, Rhizopus delemar. We searched the genome of R. delemar 99-880 for a homologue of the bacterial NRPS-independent siderophore (NIS) protein, SfnaD, that is involved in biosynthesis of staphyloferrin A in Staphylococcus aureus...
June 10, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28584909/a-review-of-phosphate-binders-in-chronic-kidney-disease-incremental-progress-or-just-higher-costs
#9
REVIEW
Wendy L St Peter, Lori D Wazny, Eric Weinhandl, Katie E Cardone, Joanna Q Hudson
As kidney disease progresses, phosphorus retention also increases, and phosphate binders are used to treat hyperphosphatemia. Clinicians prescribe phosphate binders thinking that reducing total body burden of phosphorus may decrease risks of mineral and bone disorder, fractures, cardiovascular disease, progression of kidney disease, and mortality. Recent meta-analyses suggest that sevelamer use results in lower mortality than use of calcium-containing phosphate binders. However, studies included in meta-analyses show significant heterogeneity, and exclusion or inclusion of specific studies alters results...
July 2017: Drugs
https://www.readbyqxmd.com/read/28583206/iron-availability-affects-west-nile-virus-infection-in-its-mosquito-vector
#10
Jean-Bernard Duchemin, Prasad N Paradkar
BACKGROUND: Mosquitoes are responsible for transmission of viruses, including dengue, West Nile and chikungunya viruses. Female mosquitoes are infected when they blood-feed on vertebrates, a required step for oogenesis. During this process, mosquitoes encounter high iron loads. Since iron is an essential nutrient for most organisms, including pathogens, one of the defense mechanisms for the host includes sequestration of iron away from the invading pathogen. Here, we determine whether iron availability affects viral replication in mosquitoes...
June 5, 2017: Virology Journal
https://www.readbyqxmd.com/read/28578696/nasal-delivery-of-nanoliposome-encapsulated-ferric-ammonium-citrate-can-increase-the-iron-content-of-rat-brain
#11
Xueling Guo, Hong Zheng, Yuetong Guo, Yan Wang, Gregory J Anderson, Yunzhe Ci, Peng Yu, Lina Geng, Yan-Zhong Chang
BACKGROUND: Iron deficiency in children can have significant neurological consequences, and iron supplementation is an effective treatment of choice. However, traditional routes of iron supplementation do not allow efficient iron delivery to the brain due to the presence of the blood-brain barrier. So an easily delivered iron formulation with high absorption efficiency potentially could find widespread application in iron deficient infants. RESULTS: In this study, we have developed and characterized a nanovesicular formulation of ferric ammonium citrate (ferric ammonium citrate nanoliposomes, FAC-LIP) and have shown that it can increase brain iron levels in rats following nasal administration...
June 2, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28561732/ferric-citrate-controls-serum-phosphorus-in-dialysis-patients-retrospective-data%C3%A2
#12
Debra J Hain, Meredith Marinaro, David W Koeper, Melissa A Rosenthal, Salvatore Chillemi, Jennifer M Huffman, Teresa Gerbeling, James M Pritsiolas, Lisa C Loram, Pablo E Pergola
Ferric citrate is an approved phosphate binder for use in patients with chronic kidney disease on dialysis. Clinical trials demonstrated that ferric citrate controlled serum phosphorus levels and increased iron stores. The aim of this retrospective chart review was to evaluate real-world bone mineral and anemia parameter data from patients treated with ferric citrate. 92 adult dialysis patients taking ferric citrate (average starting dose of 6 tablets/day) for at least 6 months were included. Bone mineral, anemia, and iron biomarker levels were extracted from patient medical records before and during the first 6 months of ferric citrate treatment; 21 (23%) patients were phosphate binder naïve, and 71 (77%) patients had been on other phosphate binders...
July 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28531849/heterotrophy-of-filamentous-oleaginous-microalgae-tribonema-minus-for-potential-production-of-lipid-and-palmitoleic-acid
#13
Wenjun Zhou, Hui Wang, Lin Chen, Wentao Cheng, Tianzhong Liu
Heterotrophic fermentation and high valuable co-product producing are thought to be effective ways to improve the economic viability and feasibility of commercial production of microalgae biofuels. This work reported the heterotrophic cultivation of Tribonema minus for lipid and palmitoleic acid (a novel functional fatty acid) production. Firstly, the heterotrophic ability of T. minus was identified for the first time with significant promotion in biomass and lipid productivity, and glucose and urea were then selected as the optimal carbon and nitrogen sources...
September 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28523645/enhancement-of-total-lipid-yield-by-nitrogen-carbon-and-iron-supplementation-in-isolated-microalgae
#14
Ramachandran Sivaramakrishnan, Aran Incharoensakdi
The biochemical contents and biodiesel production ability of three microalgal strains grown under different sodium nitrate, sodium carbonate, and ferric ammonium citrate (iron) levels were investigated. The highest biomass and lipid contents were found in Scenedesmus sp., Chlorella sp., and Chlamydomonas sp. when grown in normal BG-11 containing sodium carbonate concentration at 0.03 g · L(-1) , and in normal BG-11 containing iron concentration (IC) at 0.009 or 0.012 g · L(-1) . Increasing the sodium nitrate level increased the biomass content, but decreased the lipid content in all three microalgae...
August 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28515173/heme-oxygenase-1-mitigates-ferroptosis-in-renal-proximal-tubule-cells
#15
Oreoluwa Adedoyin, Ravindra Boddu, Amie M Traylor, Jeremie M Lever, Subhashini Bolisetty, James George, Anupam Agarwal
Ferroptosis is an iron-dependent form of regulated, non-apoptotic cell death, which contributes to damage in models of acute kidney injury (AKI). Heme oxygenase-1 (HO-1) is a cytoprotective enzyme induced in response to cellular stress, and is protective against AKI due to its anti-apoptotic and anti-inflammatory properties. However, the role of HO-1 in regulating ferroptosis is unclear. The purpose of this study was to elucidate the role of HO-1 in regulating ferroptotic cell death in renal proximal tubule cells (PTCs)...
May 17, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28500782/melatonin-protects-bone-marrow-mesenchymal-stem-cells-against-iron-overload-induced-aberrant-differentiation-and-senescence
#16
Fan Yang, Lei Yang, Yuan Li, Gege Yan, Chao Feng, Tianyi Liu, Rui Gong, Ye Yuan, Ning Wang, Elina Idiiatullina, Timur Bikkuzin, Valentin Pavlov, Yang Li, Chaorun Dong, Dawei Wang, Yang Cao, Zhenbo Han, Lai Zhang, Qi Huang, Fengzhi Ding, Zhengang Bi, Benzhi Cai
Bone marrow mesenchymal stem cells (BMSCs) are an expandable population of stem cells which can differentiate into osteoblasts, chondrocytes and adipocytes. Dysfunction of BMSCs in response to pathological stimuli contributes to bone diseases. Melatonin, a hormone secreted from pineal gland, has been proved to be an important mediator in bone formation and mineralization. The aim of this study was to investigate whether melatonin protected against iron overload-induced dysfunction of BMSCs and its underlying mechanisms...
May 13, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28494293/fate-of-arsenic-before-and-after-chemical-enhanced-washing-of-an-arsenic-containing-soil-in-hong-kong
#17
Jingzi Beiyuan, Jiang-Shan Li, Daniel C W Tsang, Lei Wang, Chi Sun Poon, Xiang-Dong Li, Scott Fendorf
This study evaluated the feasibility of 2-h chemical-enhanced washing of As-containing soil resulting from geogenic sources in Hong Kong and the fate of As before and after remediation. The soil morphology and As speciation in soil was elucidated by scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffractometer, X-ray photoelectron spectroscopy, and X-ray absorption spectroscopy. Integrated analysis of the results suggests that the As (>90%) resides predominantly as arsenate bound to ferric iron oxides, with a minor contribution (<10%) from an As(III)-sulphide phase...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28465262/non-thermal-plasma-induces-a-stress-response-in-mesothelioma-cells-resulting-in-increased-endocytosis-lysosome-biogenesis-and-autophagy
#18
Lei Shi, Fumiya Ito, Yue Wang, Yasumasa Okazaki, Hiromasa Tanaka, Masaaki Mizuno, Masaru Hori, Tasuku Hirayama, Hideko Nagasawa, Des R Richardson, Shinya Toyokuni
Non-thermal plasma (NTP) is a potential new therapeutic modality for cancer. However, its mechanism of action remains unclear. Herein, we studied the effect of NTP on mesothelioma cells and fibroblasts to understand its anti-proliferative efficacy. Interestingly, NTP demonstrated greater selective anti-proliferative activity against mesothelioma cells relative to fibroblasts than cisplatin, which is used for mesothelioma treatment. The anti-proliferative effect of NTP was enhanced by pre-incubation with the cellular iron donor, ferric ammonium citrate (FAC), and inhibited by iron chelation using desferrioxamine (DFO)...
May 2, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28465088/nrf2-are-signaling-provides-neuroprotection-in-traumatic-brain-injury-via-modulation-of-the-ubiquitin-proteasome-system
#19
Hui Ding, Xiaoliang Wang, Handong Wang, Lin Zhu, Qiang Wang, Yue Jia, Wuting Wei, Chenhui Zhou, Heming Wu, Ke Ding
The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway exhibits protective effects in a variety of neurological diseases. However, the role of this pathway in traumatic brain injury (TBI) is not fully understood. This study investigates whether the Nrf2-ARE pathway provides neuroprotection following TBI via regulation of the ubiquitin proteasome system (UPS), and examines the involvement of this pathway in redox homeostasis. We found that activation the Nrf2-ARE pathway can mitigate secondary brain injury induced by TBI...
April 29, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28415572/inhibition-of-iron-overload-induced-apoptosis-and-necrosis-of-bone-marrow-mesenchymal-stem-cells-by-melatonin
#20
Fan Yang, Yuan Li, Gege Yan, Tianyi Liu, Chao Feng, Rui Gong, Ye Yuan, Fengzhi Ding, Lai Zhang, Elina Idiiatullina, Valentin Pavlov, Zhenbo Han, Wenya Ma, Qi Huang, Ying Yu, Zhengyi Bao, Xiuxiu Wang, Bingjie Hua, Zhimin Du, Benzhi Cai, Lei Yang
Iron overload induces severe damage to several vital organs such as the liver, heart and bone, and thus contributes to the dysfunction of these organs. The aim of this study is to investigate whether iron overload causes the apoptosis and necrosis of bone marrow mesenchymal stem cells (BMSCs) and melatonin may prevent its toxicity. Perls' Prussion blue staining showed that exposure to increased concentrations of ferric ammonium citrate (FAC) induced a gradual increase of intracellular iron level in BMSCs. Trypan blue staining demonstrated that FAC decreased the viability of BMSCs in a concentration-dependent manner...
May 9, 2017: Oncotarget
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