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Ferric citrate

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https://www.readbyqxmd.com/read/29142965/ferritin-elevation-and-improved-responsiveness-to-erythropoiesis-stimulating-agents-in%C3%A2-patients-on-ferric-citrate-hydrate
#1
Keitaro Yokoyama, Masafumi Fukagawa, Takashi Akiba, Masaaki Nakayama, Toshiya Otoguro, Kana Yamada, Yasuo Nagamine, Steven Fishbane, Hideki Hirakata
Introduction: In hemodialysis patients on ferric citrate hydrate, the increase in ferritin level is mainly due to the administration of the compound. We investigated possible other factors associated with ferritin level and how erythropoietin resistance index and erythropoiesis in those patients were affected. We looked at ferritin-elevating factors using data from a Japanese phase III long-term clinical trial of ferric citrate hydrate. Methods: The factors with a strong association with ferritin levels at week 28 were selected by the process of variable selection...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29133393/sequential-induction-of-fur-regulated-genes-in-response-to-iron-limitation-in-bacillus-subtilis
#2
Hualiang Pi, John D Helmann
Bacterial cells modulate transcription in response to changes in iron availability. The ferric uptake regulator (Fur) senses intracellular iron availability and plays a central role in maintaining iron homeostasis in Bacillus subtilis Here we utilized FrvA, a high-affinity Fe(2+) efflux transporter from Listeria monocytogenes, as an inducible genetic tool to deplete intracellular iron. We then characterized the responses of the Fur, FsrA, and PerR regulons as cells transition from iron sufficiency to deficiency...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29128590/synthesis-and-characterization-of-a-new-soluble-soybean-polysaccharide-iron-iii-complex-using-ion-exchange-column
#3
Wenhong Gao, Yangping Huang, Ruixue He, Xin-An Zeng
A new ion exchange column method was investigated to synthesize the soluble soybean polysaccharide-iron(III) complex (SSPS-FeIII(1)) using soluble soybean polysaccharides (SSPS). The feasibility of ion exchange column reaction was explored firstly. Results indicated the D730 anion macroporous adsorption resin could effectively absorb SSPS and the static adsorption saturation time was 20h. The iron content of the complex reached up to 15.07% when trisodium citrate concentration was 2mg/mL. The structure of SSPS-FeIII complex synthesized by this method (SSPS-FeIII1(2)) was compared with that prepared by trisodium citrate - ferric chloride method (SSPS-FeIII2(3))...
November 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29127238/protective-effects-of-the-mechanistic-target-of-rapamycin-against-excess-iron-and-ferroptosis-in-cardiomyocytes
#4
Yuichi Baba, Jason K Higa, Briana K Shimada, Kate M Horiuchi, Tomohiro Suhara, Motoi Kobayashi, Jonathan D Woo, Hiroko Aoyagi, Karra S Marh, Hiroaki Kitaoka, Takashi Matsui
Clinical studies suggest that myocardial iron is a risk factor for left ventricular remodeling in patients after myocardial infarction (MI). Ferroptosis was recently reported as a mechanism of iron-dependent non-apoptotic cell death. However, ferroptosis in the heart is not well understood. The mechanistic target of rapamycin (mTOR) protects the heart against pathological stimuli such as ischemia. To define the role of cardiac mTOR on cell survival in iron-mediated cell death, we examined cardiomyocyte (CM) cell viability under excess iron and ferroptosis conditions...
November 10, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29115497/studying-hepcidin-and-related-pathways-in-osteoblasts-using-a-mouse-model-with-insulin-receptor-substrate-1%C3%A2-loss-of-function
#5
Jia Liu, Ling Qian, Linna Guo, Yunzhi Feng
Hepcidin is one of the most important proteins in iron metabolism. In the present study, its role in iron metabolism and the associated signaling pathways involved was investigated in a mouse model with insulin receptor substrate 1‑loss of function (IRS‑/‑), and osteoblasts in the iron overload condition. Protein expression levels of hepcidin, interleukin 6 (IL‑6), bone morphogenetic protein receptor 1α and ferritin demonstrated a significant increase in the liver of the IRS‑/‑ mice compared with the IRS+/‑ and IRS+/+ mice...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29110513/ankaferd-influences-mrna-expression-of-iron-regulated-genes-during-iron-deficiency-anemia
#6
Afife Gulec, Sukru Gulec
Ankaferd Blood Stopper (ABS) comprises a mixture of plants and stops bleeding via forming a protein network by erythroid aggregation. Bleeding causes reduction of iron levels in body. It has been indicated that ABS contains significant amount of iron. Thus, we investigated the biological activity of ABS-derived iron on iron-regulated genes during iron-deficiency anemia (IDA). IDA We selected Caco-2 and HepG2 cell lines as in vitro models of human intestine and liver, respectively. Iron deficiency anemia was induced by deferoxamine...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29064631/ferric-citrate-supplementation-reduces-red-blood-cell-aggregation-and-improves-cd163-macrophage-mediated-hemoglobin-metabolism-in-a-rat-model-of-high-fat-diet-induced-obesity
#7
Ting-Yun Chang, Kai-Li Liu, Cheng Sheng Chang, Chien-Tien Su, Seu-Hwa Chen, Yu-Chieh Lee, Jung-Su Chang
SCOPE: In adults, >90% of the daily iron requirement is derived from macrophage-mediated heme iron recycling from senescent red blood cells (RBCs) or free hemoglobin (Hb). Currently, the effects of pharmacological doses of iron supplementation on RBCs and heme iron recycling in obesity are unclear. METHODS AND RESULTS: Sprague Dawley rats were fed a standard diet or a 50% high-fat diet (HFD) with (0.25, 1, and 2 g of ferric iron/kg diet) or without ferric citrate supplementation for 12 weeks...
October 24, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29042277/mir-455-3p-activates-nrf2-are-signaling-via-hdac2-and-protects-osteoblasts-from-oxidative-stress
#8
Shijun Zhang, Wenliang Wu, Guangjun Jiao, Ci Li, Haichun Liu
BACKGROUND: The important role of miR-455-3p in the pathogenesis of bone metabolism associated diseases is gradually emerging. This study aims to ascertain the involvement of miR-455-3p and its underlying mechanisms in osteoporosis. METHODS: The osteoblast cell lines MC3T3-E1 was treated with ferric ammonium citrate (FAC) to mimic a pathological environment for osteoporosis. The cytotoxic effect of iron overload was assessed by proliferation, apoptosis and oxidative stress of osteoblasts using commercial kits...
October 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28966887/rootstock-influence-on-iron-uptake-responses-in-citrus-leaves-and-their-regulation-under-the-fe-paradox-effect
#9
Mary-Rus Martinez-Cuenca, Amparo Primo-Capella, Ana Quiñones, Almudena Bermejo, Maria Angeles Forner-Giner
BACKGROUND AND AIMS: This work evaluates the regulation of iron uptake responses in Citrus leaves and their involvement in the Fe paradox effect. METHODS: Experiments were performed in field-grown 'Navelina' trees grafted onto two Cleopatra mandarin × Poncirus trifoliata (L.) Raf. hybrids with different Fe-chlorosis symptoms: 030146 (non-chlorotic) and 030122 (chlorotic). RESULTS: Chlorotic leaves were smaller than non-chlorotic ones for both dry weight (DW) and area basis, and exhibited marked photosynthetic state affection, but reduced catalase and peroxidase enzymatic activities...
2017: PeerJ
https://www.readbyqxmd.com/read/28937159/duodenal-cytochrome-b-cybrd1-ferric-reductase-functional-studies-in-cells
#10
F Schlottmann, M Vera-Aviles, G O Latunde-Dada
Dietary non-heme ferric iron is reduced by the ferric reductase enzyme, duodenal cytochrome b (Dcytb), before absorption by the divalent metal transporter 1 (DMT1). A single nucleotide polymorphism (SNP rs10455 mutant) that is located in the last exon of the Dcytb gene was reported in C282Y haemochromatosis HFE subjects. The present work therefore investigated the phenotype of this mutant Dcytb in Chinese hamster ovary (CHO) cells. These cultured cells were transfected with either wild type (WT) or the SNP vector plasmids of Dcytb...
October 18, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28894591/efficacy-of-oral-contrast-agents-for-upper-gastrointestinal-signal-suppression-in-mrcp-a-systematic-review-of-the-literature
#11
Anne Frisch, Thula C Walter, Bernd Hamm, Timm Denecke
BACKGROUND: Orally administered substances which suppress signals from gastrointestinal fluid can be used to enhance image quality in magnetic resonance cholangiopancreatography (MRCP). In daily practice, the available substances range from commercial products to regular viands such as fruit juices. PURPOSE: To provide an overview on the significance of and the substances used as gastrointestinal fluid signal suppressors in MRCP. MATERIAL AND METHODS: A systematic review of the existing literature was performed to evaluate the efficacy and efficiency of oral T2-signal suppressors in MRCP...
September 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28871946/-mechanism-for-the-inhibition-of-proliferation-and-promotion-of-apoptosis-in-huh7-5-cells-by-iron-overload
#12
Yuan Qin, Jing Wei, Yi Zhang, Ling Kang, Bibo Kang, Huanjun Shen, Xuyang Zheng, Yaning Wang, Zhansheng Jia, Ying Zhang
Objective To investigate the effect of iron overload on biological activity and apoptosis in Huh7.5 cells. Methods Huh7.5 cells were cultured in the medium supplemented with 50, 100, 200 μmol/L ferric ammonium citrate (FAC). Fluorescence microscopy was employed to determine cell iron load labeled by Phen Green FL; proliferation activity of Huh7.5 cells was evaluated by MTT assay; protein and mRNA levels of transferrin receptor (TfR1), TfR2, divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) in Huh7...
August 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28854238/elastic-network-model-of-learned-maintained-contacts-to-predict-protein-motion
#13
Ines Putz, Oliver Brock
We present a novel elastic network model, lmcENM, to determine protein motion even for localized functional motions that involve substantial changes in the protein's contact topology. Existing elastic network models assume that the contact topology remains unchanged throughout the motion and are thus most appropriate to simulate highly collective function-related movements. lmcENM uses machine learning to differentiate breaking from maintained contacts. We show that lmcENM accurately captures functional transitions unexplained by the classical ENM and three reference ENM variants, while preserving the simplicity of classical ENM...
2017: PloS One
https://www.readbyqxmd.com/read/28836584/iron-dysregulates-app-processing-accompanying-with-sapp%C3%AE-cellular-retention-and-%C3%AE-secretase-inhibition-in-rat-cortical-neurons
#14
Yu-Ting Chen, Wu-Yan Chen, Xiao-Tian Huang, Ye-Chun Xu, Hai-Yan Zhang
Amyloid precursor protein (APP) and iron both play pivotal roles in the central nervous system, but whether and how iron influences the processing of endogenous APP in neurons remain unclear. Here, we investigated the regulatory effects and underlying mechanisms of iron on non-amyloidogenic and amyloidogenic processing of APP in rat primary cortical neurons. Treatment of the neurons with ferric ammonium citrate (FAC, 100 μmol/L) markedly facilitated the non-amyloidogenic processing of APP, as evidenced by a robust increase in α-secretase-derived carboxy-terminal fragment α (CTFα)...
August 24, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28722332/functionalized-acupuncture-needle-as-surface-enhanced-resonance-raman-spectroscopy-sensor-for-rapid-and-sensitive-detection-of-dopamine-in-serum-and-cerebrospinal-fluid
#15
Pan Li, Binbin Zhou, Xiaomin Cao, Xianghu Tang, Liangbao Yang, Ling Hu, Jinhuai Liu
It is a challenge to develop a robust sensor for simple, rapid operation and sensitive detection of neurotransmitters in complex specimens. Herein, ferric citrate functionalized gold nanoparticles (CA-Fe(III) /Au NPs) are utilized to develop a facile sensor based on surface-enhanced resonance Raman spectroscopy (SERRS) for sensitive detection of dopamine (DA). The sensor is prepared by decorating the acupuncture needle with Au NPs, which enables sufficient surface-enhanced Raman spectroscopy enhancement. The CA-Fe(III) structure is highly sensitive and selective for DA due to the formation of the CA-Fe(III) -DA resonant structure; this indicates the advantages of capturing, carrying, and separating DA molecules from complicated samples in a simple operation...
October 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28642302/residual-erythropoiesis-protects-against-myocardial-hemosiderosis-in-transfusion-dependent-thalassemia-by-lowering-labile-plasma-iron-via-transient-generation-of-apotransferrin
#16
Maciej W Garbowski, Patricia Evans, Evangelia Vlachodimitropoulou, Robert Hider, John B Porter
Cardiosiderosis is a leading cause of mortality in transfusion-dependent thalassemias. Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis. Risk factors were identified in 73 patients with or without cardiosiderosis. Soluble transferrin receptor-1 levels were significantly lower in patients with cardiosiderosis (odds ratio 21). This risk increased when transfusion-iron loading rates exceeded the erythroid transferrin uptake rate (derived from soluble transferrin receptor-1) by >0...
October 2017: Haematologica
https://www.readbyqxmd.com/read/28632119/alkaliphilus-namsaraevii-sp-nov-an-alkaliphilic-iron-and-sulfur-reducing-bacterium-isolated-from-a-steppe-soda-lake
#17
Anastasiya Zakharyuk, Lyudmila Kozyreva, Elena Ariskina, Olga Troshina, Dmitry Kopitsyn, Viktoria Shcherbakova
A novel alkaliphilic spore-forming bacterium was isolated from the benthic sediments of the highly mineralized steppe Lake Khilganta (Transbaikal Region, Russia). Cells of the strain, designated Х-07-2T, were straight to slightly curved rods, Gram-stain-positive and motile. Strain Х-07-2T grew in the pH range from 7.0 to 10.7 (optimum pH 9.6-10.3). Growth was observed at 25-47 °C (optimum 30 °C) and at an NaCl concentration from 5 to 150 g l-1 with an optimum at 40 g l-1. Strain Х-07-2T was a chemo-organoheterotroph able to reduce amorphous ferric hydroxide, Fe(III) citrate and elemental sulfur in the presence of yeast extract as the electron donor...
June 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28610916/the-rhizoferrin-biosynthetic-gene-in-the-fungal-pathogen-rhizopus-delemar-is-a-novel-member-of-the-nis-gene-family
#18
Cassandra S Carroll, Clark L Grieve, Indu Murugathasan, Andrew J Bennet, Clarissa M Czekster, Huanting Liu, James Naismith, Margo M Moore
Iron is essential for growth and in low iron environments such as serum many bacteria and fungi secrete ferric iron-chelating molecules called siderophores. All fungi produce hydroxamate siderophores with the exception of Mucorales fungi, which secrete rhizoferrin, a polycarboxylate siderophore. Here we investigated the biosynthesis of rhizoferrin by the opportunistic human pathogen, Rhizopus delemar. We searched the genome of R. delemar 99-880 for a homologue of the bacterial NRPS-independent siderophore (NIS) protein, SfnaD, that is involved in biosynthesis of staphyloferrin A in Staphylococcus aureus...
June 10, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28584909/a-review-of-phosphate-binders-in-chronic-kidney-disease-incremental-progress-or-just-higher-costs
#19
REVIEW
Wendy L St Peter, Lori D Wazny, Eric Weinhandl, Katie E Cardone, Joanna Q Hudson
As kidney disease progresses, phosphorus retention also increases, and phosphate binders are used to treat hyperphosphatemia. Clinicians prescribe phosphate binders thinking that reducing total body burden of phosphorus may decrease risks of mineral and bone disorder, fractures, cardiovascular disease, progression of kidney disease, and mortality. Recent meta-analyses suggest that sevelamer use results in lower mortality than use of calcium-containing phosphate binders. However, studies included in meta-analyses show significant heterogeneity, and exclusion or inclusion of specific studies alters results...
July 2017: Drugs
https://www.readbyqxmd.com/read/28583206/iron-availability-affects-west-nile-virus-infection-in-its-mosquito-vector
#20
Jean-Bernard Duchemin, Prasad N Paradkar
BACKGROUND: Mosquitoes are responsible for transmission of viruses, including dengue, West Nile and chikungunya viruses. Female mosquitoes are infected when they blood-feed on vertebrates, a required step for oogenesis. During this process, mosquitoes encounter high iron loads. Since iron is an essential nutrient for most organisms, including pathogens, one of the defense mechanisms for the host includes sequestration of iron away from the invading pathogen. Here, we determine whether iron availability affects viral replication in mosquitoes...
June 5, 2017: Virology Journal
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