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Ferric citrate

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https://www.readbyqxmd.com/read/27898902/effect-of-ferric-ammonium-citrate-in-feedlot-diets-with-varying-dried-distillers-grains-inclusion-on-ruminal-hydrogen-sulfide-concentrations-and-steer-growth
#1
D J Pogge, M E Drewnoski, D Snider, W K Rumbeiha, S L Hansen
Angus-cross steers ( = 128) were used to examine the effects of supplementing ferric ammonium citrate (FAC; 300 mg ferric Fe/kg DM) to diets of 20, 40, or 60% dried distillers' grains plus solubles (DDGS) on growth performance, liver mineral and ruminal hydrogen sulfide (HS) concentrations, and carcass traits of finishing steers. Steers were blocked by initial BW (436 ± 10.6 kg) into pens of 4 and randomly assigned to 1 of 6 treatments ( = 5 or 6 pens per treatment) including a 20, 40, or 60% DDGS inclusion diet with (+) or without (-) 300 mg Fe/kg DM from FAC...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27884072/the-biological-effect-of-asbestos-exposure-is-dependent-on-changes-in-iron-homeostasis
#2
Andrew J Ghio, Joleen M Soukup, Lisa A Dailey, Judy H Richards, Haiyan Tong
Functional groups on the surface of fibrous silicates can complex iron. We tested the postulate that (1) asbestos complexes and sequesters host cell iron resulting in a disruption of metal homeostasis and (2) this loss of essential metal results in an oxidative stress and biological effect in respiratory epithelial cells. Exposure of BEAS-2B cells to 50 μg/mL chrysotile resulted in diminished concentrations of mitochondrial iron. Preincubation of these cells with 200 μM ferric ammonium citrate (FAC) prevented significant mitochondrial iron loss following the same exposure...
November 24, 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27862990/effects-of-ferric-citrate-supplementation-on-advanced-glycation-end-products-in-a-rat-model-of-streptozotocin-nicotinamide-induced-diabetes
#3
Kuo-Ching Chao, Seu-Hwa Chen, Chun-Chao Chang, Yu-Chieh Lee, Chi-Mei Wang, Jung-Su Chang
SCOPE: Diabetes is associated with increased risks of anemia and activation of advanced glycation end products (AGEs) and the receptor for AGEs (RAGE). However, the effects of pharmacological doses of iron supplementation on AGE metabolism are less clear. The aim was to investigate the effect of ferric citrate supplementation on AGE metabolism. METHODS AND RESULTS: Diabetes was induced in overnight starved rats by intraperitoneal injections of 40 mg/kg streptozotocin and 120 mg/kg nicotinamide...
November 10, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27852672/a-novel-selective-medium-for-isolation-of-bacteroides-fragilis-from-clinical-specimens
#4
Pak-Leung Ho, Lok-Yan Ho, Chong-Yee Yau, Man-Ki Tong, Kin-Hung Chow
A novel Bacteroides fragilis selective (BFS) medium, consisting of a brain-heart infusion agar base supplemented with yeast extract, cysteine hydrochloride, bile salts, Vitamin K, hemin, glucose, esculin, ferric ammonium citrate, bromothymol blue, gentamicin, kanamycin and novobiocin, was evaluated. When BFS agar was tested with a collection of 303 bacteria of different genera, it allowed the growth of B. fragilis as large yellow colonies with blackening of the medium after 48 h of anaerobic incubation while the growth of most other anaerobes, facultative anaerobes and aerobes were inhibited...
November 16, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27808258/significant-glial-alterations-in-response-to-iron-loading-in-a-novel-organotypic-hippocampal-slice-culture-model
#5
Sinead Healy, Jill McMahon, Peter Owens, Una FitzGerald
Aberrant iron deposition in the brain is associated with neurodegenerative disorders including Multiple Sclerosis, Alzheimer's disease and Parkinson's disease. To study the collective response to iron loading, we have used hippocampal organotypic slices as a platform to develop a novel ex vivo model of iron accumulation. We demonstrated differential uptake and toxicity of iron after 12 h exposure to 10 μM ferrous ammonium sulphate, ferric citrate or ferrocene. Having established the supremacy of ferrocene in this model, the cultures were then loaded with 0...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27791118/archaea-catalyze-iron-dependent-anaerobic-oxidation-of-methane
#6
Katharina F Ettwig, Baoli Zhu, Daan Speth, Jan T Keltjens, Mike S M Jetten, Boran Kartal
Anaerobic oxidation of methane (AOM) is crucial for controlling the emission of this potent greenhouse gas to the atmosphere. Nitrite-, nitrate-, and sulfate-dependent methane oxidation is well-documented, but AOM coupled to the reduction of oxidized metals has so far been demonstrated only in environmental samples. Here, using a freshwater enrichment culture, we show that archaea of the order Methanosarcinales, related to "Candidatus Methanoperedens nitroreducens," couple the reduction of environmentally relevant forms of Fe(3+) and Mn(4+) to the oxidation of methane...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27755990/effects-of-alpha-lipoic-acid-on-expression-of-iron-transport-and-storage-proteins-in-bv-2-microglia-cells
#7
Ping Chen, Fei-Mi Li, Yu-Fu Zhou, Christopher Qian, Juan Li, Li-Rong Jiang, Zhong-Ming Qian
BACKGROUND: The antioxidant properties of alpha-lipoic acid (ALA) are associated with its ability to reduce iron in cells and tissues, which is partly due to its inhibiting effect on iron uptake from transferrin and its promoting effect on iron deposition into ferritin. However, the relevant mechanisms are unknown. METHODS: We therefore investigated the effects of ALA on the expression of transferrin receptor 1 (TfR1), divalent metal transporter 1 (DMT1), ferroportin 1 (Fpn1) and ferritin in BV-2 microglia cells...
September 11, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27692637/a-review-of-ferric-pyrophosphate-citrate-triferic-use-in-hemodialysis-patients
#8
Tyler Albright, Akram Al-Makki, Rabih Kalakeche, Brian Shepler
PURPOSE: The objective of this short review is to evaluate the efficacy of ferric pyrophosphate citrate and to determine its place in therapy based on the current published literature. METHODS: A literature search was conducted and pared down to yield 4 placebo controlled Phase II and III clinically relevant trials. FINDINGS: Ferric pyrophosphate citrate is a new intradialytic iron supplementation product that has been found to reduce the dose of erythropoiesis-stimulating agents and intravenous iron supplementation and to increase serum ferritin concentrations...
September 27, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27615161/adherence-rates-to-ferric-citrate-as-compared-to-active-control-in-patients-with-end-stage-kidney-disease-on-dialysis
#9
Diana Jalal, Molly McFadden, Jamie P Dwyer, Kausik Umanath, Erwin Aguilar, Yoram Yagil, Barbara Greco, Mohammed Sika, Julia B Lewis, Tom Greene, Simin Goral
Introduction Oral phosphate binders are the main stay of treatment of hyperphosphatemia. Adherence rates to ferric citrate, a recently approved phosphate binder, are unknown. Methods We conducted a post-hoc analysis to evaluate whether adherence rates were different for ferric citrate vs. active control in 412 subjects with end stage kidney disease (ESKD) who were randomized to ferric citrate vs. active control (sevelamer carbonate and/or calcium acetate). Adherence was defined as percent of actual number of pills taken to total number of pills prescribed...
September 12, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27607448/astragalus-polysaccharide-attenuated-iron-overload-induced-dysfunction-of-mesenchymal-stem-cells-via-suppressing-mitochondrial-ros
#10
Fan Yang, Gege Yan, Yuan Li, Zhenbo Han, Lai Zhang, Simon Chen, Chao Feng, Qi Huang, Fengzhi Ding, Ying Yu, Chongwei Bi, Benzhi Cai, Lei Yang
BACKGROUND/AIMS: Bone marrow-derived mesenchymal stem cells (BMSCs) have the ability to differentiate into multilineage cells such as osteoblasts, chondrocytes, and cardiomyocytes. Dysfunction of BMSCs in response to pathological stimuli participates in the development of diseases such as osteoporosis. Astragalus polysaccharide (APS) is a major active ingredient of Astragalus membranaceus, a commonly used anti-aging herb in traditional Chinese medicine. The aim of this study was to investigate whether APS protects against iron overload-induced dysfunction of BMSCs and its underlying mechanisms...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27589831/cell-permeable-iron-inhibits-vascular-endothelial-growth-factor-receptor-2-signaling-and-tumor-angiogenesis
#11
Devika Kir, Manju Saluja, Shrey Modi, Annapoorna Venkatachalam, Erica Schnettler, Sabita Roy, Sundaram Ramakrishnan
Angiogenesis is important for tumor growth and metastasis. Hypoxia in tumors drives this angiogenic response by stabilizing Hypoxia Inducible Factors (HIF) and target genes like Vascular Endothelial Growth Factor (VEGF). HIF stability is regulated by Prolylhydroxylases (PHD)-mediated modification. Iron is an important cofactor in regulating the enzymatic activity of PHDs. Reducing intracellular iron, for instance, mimics hypoxia and induces a pro-angiogenic response. It is hypothesized that increasing the intracellular iron levels will have an opposite, anti-angiogenic effect...
August 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27560154/assessment-of-the-toxic-potential-of-engineered-metal-oxide-nanomaterials-using-an-acellular-model-citrated-rat-blood-plasma
#12
Patrick Thomas Gormley, Neal Ingraham Callaghan, Tyson James MacCormack, Christopher Anthony Dieni
Citrated Sprague-Dawley rat blood plasma was used as a biologically relevant exposure medium to assess the acellular toxic potential of two metal oxide engineered nanomaterials (ENMs), zinc oxide (nZnO), and cerium oxide (nCeO2). Plasma was incubated at 37 °C for up to 48 h with ENM concentrations ranging between 0 and 200 mg/L. The degree of ENM-induced oxidation was assessed by assaying for reactive oxygen species (ROS) levels using dichlorofluorescein (DCF), pH, ferric reducing ability of plasma (FRAP), lipase activity, malondialdehyde (MDA), and protein carbonyls (PC)...
October 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27558654/oral-iron-supplementation-with-sodium-ferrous-citrate-reduces-the-serum-intact-and-c-terminal-fgf23-levels-of-maintenance-hemodialysis-patients
#13
Kazuomi Yamashita, Sonoo Mizuiri, Yoshiko Nishizawa, Shigemoto Kenichiro, Shigehiro Doi, Takao Masaki
BACKGROUND/AIM: Iron deficiency stimulates fibroblast growth factor 23 (FGF23) transcription. This study aimed to determine whether oral ferrous iron (Fe(2+) ) reduces the serum FGF23 levels of iron-deficient maintenance hemodialysis (MHD) patients in the same way as oral ferric iron (Fe(3+) ). METHODS: Thirty-one MHD patients with iron deficiency were enrolled in this prospective study. Patients who had taken iron supplements during the 8 weeks before the study were excluded...
August 25, 2016: Nephrology
https://www.readbyqxmd.com/read/27557937/pharmacokinetics-of-ferric-pyrophosphate-citrate-a-novel-iron-salt-administered-intravenously-to-healthy-volunteers
#14
Raymond D Pratt, Dorine W Swinkels, T Alp Ikizler, Ajay Gupta
Ferric pyrophosphate citrate (Triferic) is a water-soluble iron salt that is administered via dialysate to maintain iron balance and hemoglobin in hemodialysis patients. This double-blind, randomized, placebo-controlled, single-, ascending-dose study was conducted to evaluate the pharmacokinetics and safety of intravenous ferric pyrophosphate citrate in 48 healthy iron-replete subjects (drug, n = 36; placebo, n = 12). Single doses of 2.5, 5.0, 7.5, or 10 mg of ferric pyrophosphate citrate or placebo were administered over 4 hours, and single doses of 15 or 20 mg of ferric pyrophosphate citrate or placebo were administered over 12 hours via intravenous infusion...
August 25, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27555544/osfrdl1-expressed-in-nodes-is-required-for-distribution-of-iron-to-grains-in-rice
#15
Kengo Yokosho, Naoki Yamaji, Jian Feng Ma
Iron (Fe) is essential for plant growth and development, but the molecular mechanisms underlying its distribution to different organs are poorly understood. We found that OsFRDL1 (FERRIC REDUCTASE DEFECTIVE LIKE 1), a plasma membrane-localized transporter for citrate, was highly expressed in the upper nodes of rice at the reproductive growth stage. OsFRDL1 was expressed in most cells of enlarged vascular bundles, diffuse vascular bundles, and the interjacent parenchyma cell bridges of uppermost node I, as well as vascular tissues of the leaf blade, leaf sheath, peduncle, rachis, husk, and stamen...
October 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27498774/acetylcholinesterase-independent-protective-effects-of-huperzine-a-against-iron-overload-induced-oxidative-damage-and-aberrant-iron-metabolism-signaling-in-rat-cortical-neurons
#16
Ling-Xue Tao, Xiao-Tian Huang, Yu-Ting Chen, Xi-Can Tang, Hai-Yan Zhang
AIM: Iron dyshomeostasis is one of the primary causes of neuronal death in Alzheimer's disease (AD). Huperzine A (HupA), a natural inhibitor of acetylcholinesterase (AChE), is a licensed anti-AD drug in China and a nutraceutical in the United Sates. Here, we investigated the protective effects of HupA against iron overload-induced injury in neurons. METHODS: Rat cortical neurons were treated with ferric ammonium citrate (FAC), and cell viability was assessed with MTT assays...
November 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27481217/iron-overload-induced-calcium-signals-modulate-mitochondrial-fragmentation-in-ht-22-hippocampal-neuron-cells
#17
Dong Gil Lee, Junghyung Park, Hyun-Shik Lee, Sang-Rae Lee, Dong-Seok Lee
Iron is necessary for neuronal functions; however, excessive iron accumulation caused by impairment of iron balance could damage neurons. Neuronal iron accumulation has been observed in several neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Nevertheless, the precise mechanisms underlying iron toxicity in neuron cells are not fully understood. In this study, we investigated the mechanism underlying iron overload-induced mitochondrial fragmentation in HT-22 hippocampal neuron cells that were incubated with ferric ammonium citrate (FAC)...
July 15, 2016: Toxicology
https://www.readbyqxmd.com/read/27406686/fe3o4-carbon-nanosheets-for-all-solid-state-supercapacitor-electrodes
#18
Huailin Fan, Ruiting Niu, Jiaqi Duan, Wei Liu, Wenzhong Shen
Fe3O4@carbon nanosheet composites were synthesized using ammonium ferric citrate as the Fe3O4/carbon precursor and graphene oxide as the structure-directing agent under a hydrothermal process. The surface chemical compositions, pore structures, and morphology of the composite were analyzed and characterized by nitrogen adsorption isotherms, TG analysis, FT-IR, X-ray photoelectron energy spectrum, transmission electron microscopy, and scanning electron microscopy. The composites showed excellent specific capacitance of 586 F/g, 340 F/g at 0...
August 3, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27381468/anaerosporomusa-subterranea-gen-nov-sp-nov-a-spore-forming-anaerobe-belonging-to-the-class-negativicutes-isolated-from-saprolite
#19
Jessica K Choi, Madhavi Shah, Nathan Yee
A Gram-stain-negative, spore-forming, anaerobic bacterium designated strain RU4T was isolated from a saprolite core collected from Oak Ridge, Tennessee, USA. Cells were slightly curved rods and exhibited an outer membrane exterior to a thin cell wall. Strain RU4T formed heat-resistant endospores in late-log phase and stationary phase cultures. Under anaerobic conditions, strain RU4T grew by fermenting fumarate and maleate, but did not grow on glucose, glycerol, pyruvate, lactate, succinate, citrate, formate, acetate, propionate, butyrate or valerate...
October 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27294920/studies-to-prevent-degradation-of-recombinant-fc-fusion-protein-expressed-in-mammalian-cell-line-and-protein-characterization
#20
Sanjukta Chakrabarti, Colin J Barrow, Rupinder K Kanwar, Venkata Ramana, Jagat R Kanwar
Clipping of recombinant proteins is a major issue in animal cell cultures. A recombinant Fc-fusion protein, VEGFR1(D1-D3)-Fc expressed in CHOK1SV GS-KO cells was observed to be undergoing clippings in lab scale cultures. Partial cleaving of expressed protein initiated early on in cell culture and was observed to increase over time in culture and also on storage. In this study, a few parameters were explored in a bid to inhibit clipping in the fusion protein The effects of culture temperature, duration of culture, the addition of an anti-clumping agent, ferric citrate and use of protease inhibitor cocktail on inhibition of proteolysis of the Fc fusion were studied...
2016: International Journal of Molecular Sciences
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