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danielle mcauliffe

Ajay S Pillai, Danielle McAuliffe, Balaji M Lakshmanan, Stewart H Mostofsky, Nathan E Crone, Joshua B Ewen
Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task-related changes in connectivity in disorder-relevant behavioral paradigms. In this paper, we examined the task-related changes in functional connectivity using EEG and a movement-based paradigm that has behavioral relevance to ASD. Resting-state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor-control task...
September 12, 2017: Autism Research: Official Journal of the International Society for Autism Research
Danielle Cotter, Michael J Turner, Fionnuala M McAuliffe, Mary F Higgins
OBJECTIVE: To study the educational value to medical students of a labour ward rotation. DESIGN: Qualitative research study was performed in two tertiary level obstetric hospitals attached to a large medical school in Dublin. Medical students attending a six-week rotation in Obstetrics and Gynaecology in University College Dublin were invited to participate. As part of this rotation, students spend one week as part of the clinical team working on the labour ward...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Danielle McAuliffe, Ajay S Pillai, Alyssa Tiedemann, Stewart H Mostofsky, Joshua B Ewen
Children with autism spectrum disorders (ASD) have long been known to have deficits in the performance of praxis gestures; these motor deficits also correlate with social and communicative deficits. To date, the precise nature of the errors involved in praxis has not been clearly mapped out. Based on observations of individuals with ASD performing gestures, we hypothesized that the simultaneous execution of multiple movement elements is especially impaired in affected children. We examined 25 school-aged participants with ASD and 25 age-matched controls performing seven simultaneous gestures that required the concurrent performance of movement elements and nine serial gestures, in which all elements were performed serially...
April 2017: Autism Research: Official Journal of the International Society for Autism Research
Joshua B Ewen, Balaji M Lakshmanan, Ajay S Pillai, Danielle McAuliffe, Carrie Nettles, Mark Hallett, Nathan E Crone, Stewart H Mostofsky
Autism spectrum disorders (ASD) are thought to result in part from altered cortical excitatory-inhibitory balance; this pathophysiology may impact the generation of oscillations on electroencephalogram (EEG). We investigated premotor-parietal cortical physiology associated with praxis, which has strong theoretical and empirical associations with ASD symptomatology. Twenty five children with high-functioning ASD (HFA) and 33 controls performed a praxis task involving the pantomiming of tool use, while EEG was recorded...
2016: Frontiers in Human Neuroscience
Joshua B Ewen, Ajay S Pillai, Danielle McAuliffe, Balaji M Lakshmanan, Katarina Ament, Mark Hallett, Nathan E Crone, Stewart H Mostofsky
Our primary goal was to develop and validate a task that could provide evidence about how humans learn praxis gestures, such as those involving the use of tools. To that end, we created a video-based task in which subjects view a model performing novel, meaningless one-handed actions with kinematics similar to praxis gestures. Subjects then imitated the movements with their right hand. Trials were repeated six times to examine practice effects. EEG was recorded during the task. As a control, subjects watched videos of a model performing a well-established (over learned) tool-use gesture...
2016: Frontiers in Human Neuroscience
Claudio F Sturino, Gary O'Neill, Nicolas Lachance, Michael Boyd, Carl Berthelette, Marc Labelle, Lianhai Li, Bruno Roy, John Scheigetz, Nancy Tsou, Yves Aubin, Kevin P Bateman, Nathalie Chauret, Stephen H Day, Jean-François Lévesque, Carmai Seto, Jose H Silva, Laird A Trimble, Marie-Claude Carriere, Danielle Denis, Gillian Greig, Stacia Kargman, Sonia Lamontagne, Marie-Claude Mathieu, Nicole Sawyer, Deborah Slipetz, William M Abraham, Tom Jones, Malia McAuliffe, Hana Piechuta, Deborah A Nicoll-Griffith, Zhaoyin Wang, Robert Zamboni, Robert N Young, Kathleen M Metters
The discovery of the potent and selective prostaglandin D2 (PGD2) receptor (DP) antagonist [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (13) is presented. Initial lead antagonists 6 and 7 were found to be potent and selective DP antagonists (DP Ki = 2.0 nM for each); however, they both suffered from poor pharmacokinetic profiles, short half-lives and high clearance rates in rats. Rat bile duct cannulation studies revealed that high concentrations of parent drug were present in the biliary fluid (Cmax = 1100 microM for 6 and 3900 microM for 7)...
February 22, 2007: Journal of Medicinal Chemistry
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