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https://www.readbyqxmd.com/read/29457923/flipping-social-determinants-on-its-head-medical-student-perspectives-on-the-flipped-classroom-and-simulated-patients-to-teach-social-determinants-of-health
#1
N Gostelow, J Barber, F Gishen, A Berlin
BACKGROUND: Inequalities in healthcare are increasing. Engaging medical students to tackle this urgent challenge alongside clinical sciences can be demanding. This study examines medical student perceptions of a flipped approach to health inequalities co-designed by faculty and sixth-year students. INNOVATION: A flipped learning session was piloted for year 4 medical students combining an online lesson followed by a tutorial with a simulated patient. METHODS: A mixed-methods approach collected questionnaire data using 4-point Likert scales and free text answers...
February 19, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29457336/high-school-biology-students-use-of-visual-molecular-dynamics-as-an-authentic-tool-for-learning-about-modeling-as-a-professional-scientific-practice
#2
Stephen R Burgin, Jennifer Oramous, Michael Kaminski, Linda Stocker, Mahmoud Moradi
Modeling is a practice of science that is underemphasized in biology classrooms in comparison to its central focus in the physical sciences. Visualizations of the submicroscopic world of molecules are becoming increasingly sophisticated with the evolution of new technologies. With this in mind, we introduced high school biology classrooms to a professional molecular modeling software program used by research biochemists to visualize proteins and other macromolecules. Analysis of surveys completed before and after the use of the program revealed significant student gains in their understandings of the nature of models...
February 19, 2018: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29456381/evaluation-of-teaching-clinical-pharmacology-of-antiarrhythmic-drugs-to-first-year-mbbs-students-through-worksheet-based-small-group-discussion
#3
Ameya A Hasamnis, Aditya Arya
Cardiac arrhythmias are a major cause of morbidity and mortality across the world. Learning the science behind the use of antiarrhythmic drugs is essential for all medical graduates. However, many antiarrhythmic drugs are available, and most of them have complex pharmacodynamic and pharmacokinetic profiles. We tried to improvise our teaching by conducting interactive, worksheet-based, small-group discussion on antiarrhythmic drugs with preclinical students of School of Medicine, Taylor's University, Malaysia...
October 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29453548/-big-data-from-clinical-routine
#4
REVIEW
U Mansmann
BACKGROUND: Over the past 100 years, evidence-based medicine has undergone several fundamental changes. Through the field of physiology, medical doctors were introduced to the natural sciences. Since the late 1940s, randomized and epidemiological studies have come to provide the evidence for medical practice, which led to the emergence of clinical epidemiology as a new field in the medical sciences. Within the past few years, big data has become the driving force behind the vision for having a comprehensive set of health-related data which tracks individual healthcare histories and consequently that of large populations...
February 16, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29451874/a-stochastic-and-dynamical-view-of-pluripotency-in-mouse-embryonic-stem-cells
#5
Yen Ting Lin, Peter G Hufton, Esther J Lee, Davit A Potoyan
Pluripotent embryonic stem cells are of paramount importance for biomedical sciences because of their innate ability for self-renewal and differentiation into all major cell lines. The fateful decision to exit or remain in the pluripotent state is regulated by complex genetic regulatory networks. The rapid growth of single-cell sequencing data has greatly stimulated applications of statistical and machine learning methods for inferring topologies of pluripotency regulating genetic networks. The inferred network topologies, however, often only encode Boolean information while remaining silent about the roles of dynamics and molecular stochasticity inherent in gene expression...
February 16, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29446316/impact-of-the-inbre-summer-student-mentored-research-program-on-undergraduate-students-in-arkansas
#6
Jean C McSweeney, Teresa J Hudson, Latrina Prince, Helen Beneš, Alan J Tackett, Caroline Miller Robinson, Roger Koeppe, Lawrence E Cornett
The Institutional Development Award (IDeA) program, housed within the National Institute for General Medical Sciences, administers the Networks of Biomedical Research Excellence (INBRE) as a strategic mission to broaden the geographic distribution of National Institutes of Health (NIH) funding within the United States. Undergraduate summer student mentored research programs (SSMRP) are a common feature of INBRE programs and are designed to increase undergraduate student interest in research careers in the biomedical sciences...
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29443053/neuroimaging-field-methods-using-functional-near-infrared-spectroscopy-nirs-neuroimaging-to-study-global-child-development-rural-sub-saharan-africa
#7
Kaja K Jasińska, Sosthène Guei
Portable neuroimaging approaches provide new advances to the study of brain function and brain development with previously inaccessible populations and in remote locations. This paper shows the development of field functional Near Infrared Spectroscopy (fNIRS) imaging to the study of child language, reading, and cognitive development in a rural village setting of Côte d'Ivoire. Innovation in methods and the development of culturally appropriate neuroimaging protocols allow a first-time look into the brain's development and children's learning outcomes in understudied environments...
February 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29441527/global-macroevolution-and-macroecology-of-passerine-song
#8
William D Pearse, Ignacio Morales-Castilla, Logan S James, Maxwell Farrell, Frédéric Boivin, T Jonathan Davies
Studying the macroevolution of the songs of Passeriformes (perching birds) has proved challenging. The complexity of the task stems not just from the macroevolutionary and macroecological challenge of modelling so many species, but also from the difficulty in collecting and quantifying birdsong itself. Using machine learning techniques, we extracted songs from a large citizen science dataset, and then analysed the evolution, and biotic and abiotic predictors of variation in birdsong across 578 passerine species...
February 14, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29438072/using-a-network-organisational-architecture-to-support-the-development-of-learning-healthcare-systems
#9
Maria T Britto, Sandra C Fuller, Heather C Kaplan, Uma Kotagal, Carole Lannon, Peter A Margolis, Stephen E Muething, Pamela J Schoettker, Michael Seid
The US National Academy of Sciences has called for the development of a Learning Healthcare System in which patients and clinicians work together to choose care, based on best evidence, and to drive discovery as a natural outgrowth of every clinical encounter to ensure innovation, quality and value at the point of care. However, the vision of a Learning Healthcare System has remained largely aspirational. Over the last 13 years, researchers, clinicians and families, with support from our paediatric medical centre, have designed, developed and implemented a network organisational model to achieve the Learning Healthcare System vision...
February 5, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29437774/uncharted-waters-next-generation-sequencing-and-machine-learning-software-allow-forensic-science-to-expand-into-phenotype-prediction-from-dna-samples
#10
https://www.readbyqxmd.com/read/29434042/maximizing-the-information-learned-from-finite-data-selects-a-simple-model
#11
Henry H Mattingly, Mark K Transtrum, Michael C Abbott, Benjamin B Machta
We use the language of uninformative Bayesian prior choice to study the selection of appropriately simple effective models. We advocate for the prior which maximizes the mutual information between parameters and predictions, learning as much as possible from limited data. When many parameters are poorly constrained by the available data, we find that this prior puts weight only on boundaries of the parameter space. Thus, it selects a lower-dimensional effective theory in a principled way, ignoring irrelevant parameter directions...
February 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29434004/a-systematic-review-of-adolescent-girl-program-implementation-in-low-and-middle-income-countries-evidence-gaps-and-insights
#12
REVIEW
Nicole A Haberland, Katharine J McCarthy, Martha Brady
Increasing attention to adolescent girls has generated an abundance of programs and a growing body of research on adolescent girls in low- and middle-income countries. Despite this, questions remain about what implementation approaches in program design are most effective, hindering efficient resource allocation, program scale-up, and replication across settings. To address these questions, we conducted a systematic review to identify lessons learned and gaps in the evidence base. We searched four electronic databases to identify studies published between 1990 and 2014 that evaluated health, social, and/or economic development programs targeting adolescent girls in low- and middle-income countries...
February 9, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29433505/why-nutrition-education-is-inadequate-in-the-medical-curriculum-a-qualitative-study-of-students-perspectives-on-barriers-and-strategies
#13
Victor Mogre, Fred C J Stevens, Paul A Aryee, Anthony Amalba, Albert J J A Scherpbier
BACKGROUND: The provision of nutrition care by doctors is important in promoting healthy dietary habits, and such interventions can lead to reductions in disease morbidity, mortality, and medical costs. However, medical students and doctors report inadequate nutrition education and preparedness during their training at school. Previous studies investigating the inadequacy of nutrition education have not sufficiently evaluated the perspectives of students. In this study, students' perspectives on doctors' role in nutrition care, perceived barriers, and strategies to improve nutrition educational experiences are explored...
February 12, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29433039/design-based-research-in-designing-the-model-for-educating-simulation-facilitators
#14
Jaana-Maija Koivisto, Leena Hannula, Rikke Buus Bøje, Stephen Prescott, Andrew Bland, Leena Rekola, Päivi Haho
The purpose of this article is to introduce the concept of design-based research, its appropriateness in creating education-based models, and to describe the process of developing such a model. The model was designed as part of the Nurse Educator Simulation based learning project, funded by the EU's Lifelong Learning program (2013-1-DK1-LEO05-07053). The project partners were VIA University College, Denmark, the University of Huddersfield, UK and Metropolia University of Applied Sciences, Finland. As an outcome of the development process, "the NESTLED model for educating simulation facilitators" (NESTLED model) was generated...
February 7, 2018: Nurse Education in Practice
https://www.readbyqxmd.com/read/29432176/detection-of-aneuploidy-in-patients-with-cancer-through-amplification-of-long-interspersed-nucleotide-elements-lines
#15
Christopher Douville, Simeon Springer, Isaac Kinde, Joshua D Cohen, Ralph H Hruban, Anne Marie Lennon, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Rachel Karchin
Aneuploidy is a feature of most cancer cells, and a myriad of approaches have been developed to detect it in clinical samples. We previously described primers that could be used to amplify ∼38,000 unique long interspersed nucleotide elements (LINEs) from throughout the genome. Here we have developed an approach to evaluate the sequencing data obtained from these amplicons. This approach, called Within-Sample AneupLoidy DetectiOn (WALDO), employs supervised machine learning to detect the small changes in multiple chromosome arms that are often present in cancers...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29431584/horizon-scanning-how-will-metabolomics-applications-transform-food-science-bioengineering-and-medical-innovation-in-the-current-era-of-foodomics
#16
Mustafa Bayram, Çağlar Gökırmaklı
Food and engineering sciences have tended to neglect the importance of human nutrition sciences and clinical study of new molecules discovered by food engineering community, and vice versa. Yet, the value of systems thinking and use of omics technologies in food engineering are rapidly emerging. Foodomics is a new concept and practice to bring about "precision nutrition" and integrative bioengineering studies of food composition, quality, and safety, and applications to improve health of humans, animals, and other living organisms on the planet...
February 12, 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29430558/therapeutic-angiogenesis-for-peripheral-artery-disease-lessons-learned-in-translational-science
#17
Sunil R Iyer, Brian H Annex
Peripheral arterial disease (PAD) is a major health care problem. There have been limited advances in medical therapies, and a huge burden of symptomatic patients with intermittent claudication and critical limb ischemia who have limited treatment options. Angiogenesis is the growth and proliferation of blood vessels from existing vasculature. For approximately 2 decades, "therapeutic angiogenesis" has been studied as an investigational approach to treat patients with symptomatic PAD. Despite literally hundreds of positive preclinical studies, results from human clinical studies thus far have been disappointing...
October 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/29428544/development-and-evaluation-of-a-capacity-building-program-in-gender-relevant-tobacco-control-research-a-brazilian-experience
#18
Regina C Cruz, Sharina D Person, Lorna Bittencourt, Ana C Efing, Isabel C Scarinci
INTRODUCTION: There is an increased need for capacity building of researchers and professionals in low- and middle-income countries with evidence-based approaches across the tobacco control continuum, particularly with regard to gender-relevant strategies. We describe the development, implementation, and evaluation of a Career Development and Research Training Program (CDRTP) in tobacco control. METHODS: The CDRTP is organized into two modules: Module I is open to the public and provides an overview of tobacco control; Module II, consists of a one-year program with multi-mode sessions toward the development of a pilot research project...
February 2, 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29428074/machine-learning-techniques-for-breast-cancer-computer-aided-diagnosis-using-different-image-modalities-a-systematic-review
#19
REVIEW
Nisreen I R Yassin, Shaimaa Omran, Enas M F El Houby, Hemat Allam
BACKGROUND AND OBJECTIVE: The high incidence of breast cancer in women has increased significantly in the recent years. Physician experience of diagnosing and detecting breast cancer can be assisted by using some computerized features extraction and classification algorithms. This paper presents the conduction and results of a systematic review (SR) that aims to investigate the state of the art regarding the computer aided diagnosis/detection (CAD) systems for breast cancer. METHODS: The SR was conducted using a comprehensive selection of scientific databases as reference sources, allowing access to diverse publications in the field...
March 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29427726/role-development-in-midwifery-education-a-place-for-simulation
#20
Sharon L Ruyak, Laura Migliaccio, Amy Levi, Sarah Patel
OBJECTIVE: simulation-based learning is increasingly seen as an effective strategy to develop student nurse-midwives into effective healthcare team members. A gap exists concerning the use of simulation to promote role transition/development of the student midwife. The purpose of this paper is to describe an evolving simulation curriculum aimed at role development of the student midwife as well as technical skills training. SETTING: the University of New Mexico, College of Nursing and the Interprofessional Healthcare Simulation Center...
February 2, 2018: Midwifery
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