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https://www.readbyqxmd.com/read/28436378/outcomes-of-corpectomy-in-patients-with-metastatic-cancer
#1
Grzegorz Guzik
BACKGROUND: The objective of surgical management of spinal metastases is to reduce pain and improve the patient's quality of life. The operation should restore spinal stability and decompress neural structures. One surgical technique is corpectomy followed by vertebral body reconstruction and stabilisation of the spine. The procedure may be performed in patients in overall good health and a good survival prognosis. The aim of this paper is to present the outcomes of surgical management of spinal metastases in patients who underwent corpectomy followed by vertebral body reconstruction and stabilisation of the spine...
January 26, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28436374/factors-influencing-treatment-of-proximal-femoral-fractures
#2
Sławomir Dudko, Paweł Kosior, Damian Kusz, Anna Wagner, Marcin Kusz, Karolina Godyń
BACKGROUND: Orthopaedics and traumatology departments are dominated by patients with proximal femoral fractures, who represent 20-30% of all patients treated there. The aim of this study was identification and evaluation of factors influencing treatment of proximal femoral fractures. MATERIAL AND METHODS: Between 2008 and 2015, we treated 424 femoral neck fractures and 442 trochanteric fractures in patients over 40 y/o. The impact of fracture location (femoral neck/trochanteric), character (non-displaced/displaced) and the patient's general condition (metrical/biological age, health condition) on qualification and treatment used (fixations/hip pro-sthesis/non-operative) was analyzed...
January 26, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28435237/evaluation-of-ex-press-glaucoma-implant-in-elderly-diabetic-patients-after-23g-vitrectomy
#3
Anita Lyssek-Boroń, Adam Wylęgała, Dariusz Dobrowolski, Ewelina Kowalczyk, Katarzyna Polanowska, Edward Wylęgała
PURPOSE: The most frequent qualifications for pars plana vitrectomy (PPV) in diabetic patients include recurrent hemorrhage into the vitreous body chamber and vitreoretinal proliferation, also with traction retinal detachment. The aim of this study was to evaluate the effectiveness of EX-PRESS implant for the treatment of secondary glaucoma in elderly diabetic patients following PPV 23G with silicon oil or SF6 gas endotamponade. MATERIALS AND METHODS: This retrospective analysis comprised 18 patients (19 eyes)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28431539/pain-intervention-for-people-with-dementia-in-nursing-homes-pid-study-protocol-for-a-quasi-experimental-nurse-intervention
#4
Andrea Koppitz, Georg Bosshard, Geneviève Blanc, Hannele Hediger, Sheila Payne, Thomas Volken
BACKGROUND: It is estimated that 19 to 83% of people with dementia suffer from pain that is inadequately treated in the last months of life. A large number of healthcare workers who care for these people in nursing homes lack appropriate expertise and may therefore not always recognise, assess and treat pain in those with dementia who have complex problems on time, properly and efficiently. The aim of this intervention trial is to identify care needs of people with dementia suffering from pain living in a nursing home...
April 21, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28429207/organizational-and-welfare-mode-of-breast-centers-network-a-survey-of-sicilian-radiologists
#5
Maria Adele Marino, Orazio Pennisi, Annalisa Donia, Carmelo Sofia, Claudio Guerra, Carmelo Privitera, Placido Romeo
The European Society of Breast Cancer Specialists has created quality indicators for breast units to establish the minimum standards of care for patients. In Italy, each region differs, indeed, in terms of health care and services warranted to patients suffering from breast cancer. Since Sicilian Regional Administration today is still disregarding implementation of the provisions contained in the proposal of the Ministry of Health entitled "Guidelines on Organizational and Health Care Methods of Breast Centers Network" in November 2015 the Sicilian Regional Group of the Italian Society of Radiology (SIRM) decided to carry out a survey to see the position of the Sicilian Healthcare System and define the gap to bridge over...
April 20, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28428156/user-interest-in-digital-health-technologies-to-encourage-physical-activity-results-of-a-survey-in-students-and-staff-of-a-german-university
#6
Annett Salzwedel, Sophie Rabe, Thomas Zahn, Julia Neuwirth, Sarah Eichler, Kathrin Haubold, Anne Wachholz, Rona Reibis, Heinz Völler
BACKGROUND: Although the benefits for health of physical activity (PA) are well documented, the majority of the population is unable to implement present recommendations into daily routine. Mobile health (mHealth) apps could help increase the level of PA. However, this is contingent on the interest of potential users. OBJECTIVE: The aim of this study was the explorative, nuanced determination of the interest in mHealth apps with respect to PA among students and staff of a university...
April 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28422598/the-use-of-restorative-materials-in-primary-molars-among-pediatric-dentists-in-israel
#7
Sigalit Blumer, Benjamin Peretz, Tal Ratson
OBJECTIVES: To assess the current choice of various restoration materials among Israeli pediatric dentists according to seniority and specialty. STUDY DESIGN: Participating dentists completed a 23-item questionnaire on their qualifications, type of practice and preference of restorative material. RESULTS: Seventy-five dentists (average age 46.27±12.6 years, 58 females) participated. Forty-one were specialist pediatric dentists and 34 were general practitioners...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28418362/-individual-learning-curves-for-microsurgical-myocardial-revascularization
#8
A N Semchenko, A A Sadykov
AIM: To create individual learning curves for microsurgical myocardial revascularization. MATERIAL AND METHODS: It was analyzed duration of the individual stages of the first 100 CABG procedures which were performed using microsurgical technique and surgical microscope. Graphs reflecting correlation between duration of the individual surgical stages and their number were framed. RESULTS: Improvement in distal anastomosis time, aortic cross-clamping time, cardiopulmonary bypass time and duration of surgery was observed with increased surgeon's experience...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28416124/assessment-of-the-external-validity-of-the-national-comprehensive-cancer-network-and-european-society-for-medical-oncology-guidelines-for-non-small-cell-lung-cancer-in-a-population-of-patients-aged-80-years-and-older
#9
REVIEW
Nicolò Matteo Luca Battisti, Marina Sehovic, Martine Extermann
Non-small-cell lung cancer (NSCLC) is a disease of the elderly, who are under-represented in clinical trials. This challenges the external validity of the evidence base for its management and of current guidelines, that we evaluated in a population of older patients. We retrieved randomized clinical trials (RCTs) supporting the guidelines and identified 18 relevant topics. We matched a cohort of NSCLC patients aged older than 80 years from the Moffitt Cancer Center database with the studies' eligibility criteria to check their qualification for at least 2 studies...
March 21, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28411013/physician-reported-factors-that-encourage-collaboration-with-community-pharmacists
#10
Nicole C Pezzino, Macary Weck Marciniak, Megan G Smith, Stefanie P Ferreri
OBJECTIVE: To determine factors that encourage physicians to establish collaborative practice agreements with community pharmacists. METHODS: A 20-item cross-sectional survey was mailed to a random sample of 1000 family medicine physicians practicing in North Carolina. Two weeks after the initial mailing, a reminder was sent to physicians. Physicians were entered into a drawing to receive a gift card as an incentive for survey completion. The questionnaire collected demographic information, factors important to physicians for collaboration with a community pharmacist, and physician perceptions of pharmacist qualifications...
April 12, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28408004/development-of-the-diary-for-irritable-bowel-syndrome-symptoms-to-assess-treatment-benefit-in-clinical-trials-foundational-qualitative-research
#11
MULTICENTER STUDY
Sheri E Fehnel, Claire M Ervin, Robyn T Carson, Gianna Rigoni, Jeffrey M Lackner, Stephen Joel Coons
BACKGROUND: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and alterations in bowel habits. Three subtypes are defined on the basis of stool patterns: diarrhea-predominant IBS, constipation-predominant IBS, and alternating or mixed IBS. OBJECTIVES: To develop patient-reported outcome measures for qualification by the Food and Drug Administration to support product approvals and labeling in IBS; the article focuses on the qualitative research that provided the foundation for the new measures...
April 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28406093/antiviral-activity-of-nobiletin-against-chikungunya-virus-in-vitro
#12
Shih-Chao Lin, Mei-Chun Chen, Shiming Li, Chi-Chen Lin, Tony T Wang
BACKGROUND: Chikungunya virus (CHIKV), a highly contagious re-emerging virus, is transmitted by infected mosquitoes. CHIKV is prevalent in tropical countries and is continuing to creep farther north into temperate areas. CHIKV is responsible for induction of Chikungunya Fever (CF) and severe joint stiffness with the capability of developing into bilateral and systemic arthralgia or even encephalitis. Despite the high morbidity rate, no approved antiviral drug is available. Therefore, an anti-CHIKV therapy is necessary to control this disease...
April 13, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28404887/the-mutation-of-trp64arg-in-%C3%AE-3-adrenoreceptor-encoding-gene-is-significantly-associated-with-increased-hypertension-risk-and-elevated-blood-pressure-a-meta-analysis
#13
Hualing Yang, Dongmiao Cai, Qingping Zhu, Dongjin Wu, Qingxiang Wang, Zhanxiang Wang
This meta-analysis was implemented to test the association of a missense mutation, Trp64Arg, in β3-adrenoreceptor-encoding gene (ADRB3) with both hypertension risk and blood pressure (BP) changes. A systematic search of three publicly-available databases was launched to look for articles published as of December 2016. Qualification appraisal and data extraction were independently done by two researchers. Pooled estimates were expressed as odds ratio (OR) or weighted mean difference (WMD), and their 95% confidence intervals (95% CIs)...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28403301/conformity-of-nurse-prescribing-to-care-needs-nurses-understanding
#14
Marília Silveira Faeda, Márcia Galan Perroca
OBJECTIVE: investigate the understanding of nurses on nurse prescribing conformity to the care needs of hospitalized patients and factors associated with that conformity. METHOD: a descriptive study, with a quantitative approach, was conducted at 20 in-patient units of a teaching hospital in the state of São Paulo. The participants (N=139) answered a semi-structured questionnaire. RESULTS: For 43 (30.9%) nurses, nurse prescribing is always in line with patients' care needs...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28403079/toward-a-mediation-model-for-nurses-well-being-and-psychological-distress-effects-of-quality-of-leadership-and-social-support-at-work
#15
Beatrice I J M Van der Heijden, Regina H Mulder, Christoph König, Veronika Anselmann
Given the lack of active nurses in industrialized countries throughout the world, in combination with demographic changes, it is of utmost importance to protect nurses' well-being and to prevent psychological distress, because of their strong association with premature occupational leave. The aim of this study was to investigate the effects of quality of leadership and social support at work on well-being and psychological distress of nurses and to determine whether nurses' overcommitment mediates the relationship between the abovementioned determinants and the outcomes...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28402432/educational-outcomes-of-a-medical-physicist-program-over-the-past-10%C3%A2-years-in-japan
#16
Noriyuki Kadoya, Kumiko Karasawa, Iori Sumida, Hidetaka Arimura, Yasumasa Kakinohana, Shigeto Kabuki, Hajime Monzen, Teiji Nishio, Hiroki Shirato, Syogo Yamada
The promotion plan for the Platform of Human Resource Development for Cancer (Ganpro) was initiated by the Ministry of Education, Culture, Sports, Science and Technology of Japan in 2007, establishing a curriculum for medical physicists. In this study, we surveyed the educational outcomes of the medical physicist program over the past 10 years since the initiation of Ganpro. The Japan Society of Medical Physics mailing list was used to announce this survey. The questionnaire was created by members of the Japanese Board for Medical Physicist Qualification, and was intended for the collection of information regarding the characteristics and career paths of medical physics students...
April 11, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28401823/-socioeconomic-differences-and-smoking-clear-connections-with-implications-for-tobacco-policy
#17
A E Kunst
- Smoking is more common among people with a lower educational level, professional qualifications and income. This is a major contributor to inequalities in health and mortality.- Inequalities in smoking appear to have their origin in early adolescence. Later in life these inequalities increase due to differences in smoking cessation between higher and lower socioeconomic status groups.- The inequalities in smoking cessation have already been explained in great detail. The close association between smoking and a lower level of education during adolescence is much less clear...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28398693/development-and-qualification-of-physiologically-based-pharmacokinetic-models-for-drugs-with-atypical-distribution-behavior-a-desipramine-case-study
#18
T S Samant, V Lukacova, S Schmidt
Desipramine is a secondary tricyclic amine, which is primarily metabolized by cytochrome 2D6. It shows a high volume of distribution (Vss) (10-50 L/kg) due to its high lipophilicity, unspecific phospholipid binding, and lysosomal trapping. The objective of this study was to develop and qualify a physiologically based pharmacokinetic (PBPK) model for desipramine, which accounts for the high Vss of the drug following intravenous and oral administration of doses up to 100 mg. The model also accounts for the extended time to reach maximum concentration after oral dosing due to enterocyte trapping...
April 11, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28395794/performance-observations-of-scanner-qualification-of-nci-designated-cancer-centers-results-from-the-centers-of-quantitative-imaging-excellence-cqie-program
#19
Mark Rosen, Paul E Kinahan, James F Gimpel, Adam Opanowski, Barry A Siegel, G Craig Hill, Linda Weiss, Lalitha Shankar
We present an overview of the Centers for Quantitative Imaging Excellence (CQIE) program, which was initiated in 2010 to establish a resource of clinical trial-ready sites within the National Cancer Institute (NCI)-designated Cancer Centers (NCI-CCs) network. The intent was to enable imaging centers in the NCI-CCs network capable of conducting treatment trials with advanced quantitative imaging end points. We describe the motivations for establishing the CQIE, the process used to initiate the network, the methods of site qualification for positron emission tomography, computed tomography, and magnetic resonance imaging, and the results of the evaluations over the subsequent 3 years...
February 2017: Academic Radiology
https://www.readbyqxmd.com/read/28395097/artesunate-to-treat-severe-malaria-in-travellers-review-of-efficacy-and-safety-and-practical-implications
#20
Camille Roussel, Eric Caumes, Marc Thellier, Papa Alioune Ndour, Pierre A Buffet, Stéphane Jauréguiberry
Background: Artesunate (AS) is the WHO first-line treatment of severe malaria in endemic countries, in adults and children. However, despite solid evidence that AS is safe and more effective than quinine in endemic areas, its deployment in non-endemic areas has been slow, due in part to the absence of a full good manufacturing practice (GMP) qualification (although prequalification has been granted in 2010). Prospective comparative trials were not conducted in travellers, but several retrospective studies and case reports are providing insights into the efficacy and safety of AS in imported severe malaria...
March 1, 2017: Journal of Travel Medicine
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