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https://www.readbyqxmd.com/read/29222033/multiple-perspectives-of-qingkailing-injection-fraction-single-compound-in-revealing-the-hepatotoxicity-of-baicalin-and-hyodeoxycholic-acid
#1
Jiayu Zhang, Shifeng Wang, Lulu Xu, Qiao Zhang, Zhanpeng Shang, Yanling Zhang, Qinghua Wu, Shiyou Li, Yanjiang Qiao
ETHNOPHARMACOLOGICAL RELEVANCE: The complexity of ingredients in traditional Chinese medical formulas and the limited consideration of toxicological responses are fundamental issues that hamper prognostic information of drug quality control. MATERIALS AND METHODS: A multidisciplinary approach for quality control of Qingkailing injection (QKL) regarding drug induced liver toxicity was described for the first time. High content image analysis (HCA) was combined with reverse-phase chromatographic separation and high-resolution MS detection technologies to provide the dynamic responses of HepG2 cell injury...
December 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29218359/-significance-of-the-doctorate-in-scientific-medical-education
#2
Matthias Frosch
According to European and German law, the medical education of physicians must take place in a scientific degree program at a university or under the supervision of a university. To keep up the ideal of a scientific degree program, various organizations and associations, such as the German Research Foundation, the German Council of Science and Humanities and the German Medical Faculty Association, see the need for an even stronger anchoring of academic learning content in the course of study. Traditionally, a scientific project, which is carried out during the studies, provides the basis for the Doctor of Medicine (Dr...
December 7, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29217871/development-and-validation-of-european-guidelines-for-seismic-qualification-of-post-installed-anchors
#3
Philipp Mahrenholtz, Richard L Wood, Rolf Eligehausen, Tara C Hutchinson, Matthew S Hoehler
This paper presents the technical background for the seismic qualification procedures for post-installed anchors in the European Technical Approval Guideline (ETAG 001) seismic annex issued in 2013. We discuss requirements for a comprehensive guideline and reference supporting documentation. Numerical studies to generate new simulated seismic protocols for anchors are summarized with focus on their application to Europe. To reduce the time and cost of anchor product qualification testing while fulfilling the requirement of European building codes to assess two performance categories, we combine the results of our numerical studies to generate novel testing protocols that allow for the assessment of anchor behavior at multiple levels in a unified protocol...
October 2017: Engineering Structures
https://www.readbyqxmd.com/read/29216263/roles-responsibilities-and-characteristics-of-lay-community-health-workers-involved-in-diabetes-prevention-programmes-a-systematic-review
#4
Jillian Hill, Nasheeta Peer, Brian Oldenburg, Andre Pascale Kengne
AIM: To examine the characteristics of community health workers (CHWs) involved in diabetes prevention programmes (DPPs) and their contributions to expected outcomes. METHODS: Electronic databases including PubMed-MEDLINE, EBSCOHost, and SCOPUS/EMBASE were searched for studies published between January 2000 and March 2016. All studies that used CHWs to implement DPP in ≥18-year-old participants without diabetes but at high risk for developing the condition, irrespective of the study design, setting or outcomes measured, were included...
2017: PloS One
https://www.readbyqxmd.com/read/29215127/midwives-in-england-and-in-italy-two-realities-compared
#5
C Dell'Omodarme, G Bocci, G Troiano, S Rossi, L Kundisova, N Nante, L Alaimo
BACKGROUND: Midwives have the responsibility to provide assistance to pregnant women for non-complicated deliveries. The aim of this study was to identify the distinctive features of midwives in Italy and in England in order to provide interesting comparisons. METHODS: From September to October 2015 we administered an online questionnaire to groups of Italian and English midwives. The questionnaire was composed by a part trying to collect the sociodemographic information and a second part to define the attitudes of care and the type of approach to birth and degree of attained professional autonomy...
January 2018: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29214929/-for-me-pressure-at-school-is-the-most-relevant-in-my-life-empirical-based-implications-for-life-world-orientation-in-health-promotion-at-school
#6
Anna Lena Rademaker
"For me, Pressure at School is the Most Relevant in my Life" - Empirical Based Implications for Life World Orientation in Health Promotion at School School is a key system that supports all processes of adolescent development. Next to qualification, as one part of personality development, all developmental tasks of adolescence can take place within the school environment, through close interplay. This interplay both influences, and is influenced by young people's health which is essential to promote adolescent development and foster wellbeing in everyday life for young people...
December 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29214608/a-science-and-risk-based-pragmatic-methodology-for-blend-and-content-uniformity-assessment
#7
Naheed Sayeed-Desta, Ajay Babu Pazhayattil, Jordan Collins, Chetan Doshi
This paper describes a pragmatic approach that can be applied in assessing powder blend and unit dosage uniformity of solid dose products at Process Design, Process Performance Qualification, and Continued/Ongoing Process Verification stages of the Process Validation lifecycle. The statistically based sampling, testing, and assessment plan was developed due to the withdrawal of the FDA draft guidance for industry "Powder Blends and Finished Dosage Units-Stratified In-Process Dosage Unit Sampling and Assessment...
December 6, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29212643/designing-a-resilience-program-for-critical-care-nurses
#8
Meredith Mealer, Rachel Hodapp, David Conrad, Sona Dimidjian, Barbara O Rothbaum, Marc Moss
BACKGROUND: Workplace stress can affect job satisfaction, increase staff turnover and hospital costs, and reduce quality of patient care. Highly resilient nurses adapt to stress and use a variety of skills to cope effectively. OBJECTIVE: To gain data on a mindfulness-based cognitive therapy resilience intervention for intensive care unit nurses to see if the intervention program would be feasible and acceptable. METHODS: Focus-group interviews were conducted by videoconference with critical care nurses who were members of the American Association of Critical-Care Nurses...
2017: AACN Advanced Critical Care
https://www.readbyqxmd.com/read/29209960/systematic-reviews-meta-analyses-of-integrative-medicine-in-chinese-need-regulation-and-monitoring-urgently-and-some-suggestions-for-its-solutions
#9
Jia-Ying Wang, Gui-Hua Tian, You-Ping Li, Tai-Xiang Wu, Zhao-Xiang Bian, Liang Du, Hong-Cai Shang
With the introduction and development of evidence-based medicine in China, it has been spread rapidly in the area of integrative medicine (IM) and has become a new unique discipline. During almost 20 years, as one of the most important parts of evidence-based IM, systematic review (SR)/meta-analysis (MA) of IM have shown a good development momentum in the aspects of quantity, depth, breadth and influence, but also face the harsh situation of the uncontrolled quantity and quality, especially for SRs in Chinese...
December 5, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29205901/dissecting-the-role-of-sessional-anatomy-teachers-a-systematic-literature-review
#10
REVIEW
Danielle Rhodes, Quentin A Fogg, Michelle D Lazarus
Worldwide there is a growing reliance on sessional teachers in universities. This has impacted all disciplines in higher education including medical anatomy programs. The objective of this review was to define the role and support needs of sessional anatomy teachers by reporting on the (1) qualifications, (2) teaching role, (3) training, and (4) performance management of this group of educators. A systematic literature search was conducted on the 27 July 2017 in Scopus, Web of Science, and several databases on the Ovid, ProQuest and EBSCOhost platforms...
December 4, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29205185/knowledge-attitude-and-practices-of-primary-health-care-physicians-toward-colorectal-cancer-screening
#11
Mahmoud Mosli, Yaser Alnahdi, Abdusalam Alghamdi, Mohammad Baabdullah, Afnan Hadadi, Khaleel Khateery, Ibrahim Alsulami, Abdulaziz AlHoqail, Majid Almadi, Hani Jawa, Emad Aljahdli, Salem Bazarah, Yousif Qari
BACKGROUND/AIM: Early diagnosis of chronic illnesses and cancers mainly occurs at primary health care centers (PHCs) by primary health care physicians (PHPs). The incidence of colorectal cancer (CRC) in the Kingdom of Saudi Arabia (KSA) is rising and this has been attributed to many factors. The increasing incidence of CRC is compounded by nonadherence to screening recommendations. Therefore, evaluating PHPs knowledge, attitudes, and practices of screening for CRC is clinically important...
November 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29190816/a-national-survey-of-clinical-pharmacy-services-in-county-hospitals-in-china
#12
Dongning Yao, Xiaoyu Xi, Yuankai Huang, Hao Hu, Yuanjia Hu, Yitao Wang, Wenbing Yao
BACKGROUND: Clinical pharmacy is not only a medical science but also an elaborate public health care system firmly related to its subsystems of education, training, qualification authentication, scientific research, management, and human resources. China is a developing country with a tremendous need for improvements in the public health system, including the clinical pharmacy service system. OBJECTIVES: The aim of this research was to evaluate the infrastructure and personnel qualities of clinical pharmacy services in China...
2017: PloS One
https://www.readbyqxmd.com/read/29186881/a-novel-strategy-for-quantitative-analysis-of-major-ginsenosides-in-panacis-japonici-rhizoma-with-a-standardized-reference-fraction
#13
Fan-Cheng Meng, Qiu-Shuang Wu, Ruibing Wang, Shao-Ping Li, Li-Gen Lin, Ping Chen, Qing-Wen Zhang
Panacis Japonici Rhizoma (Zhu-Jie-Shen in Chinese), the root of P. japonicus C.A. Mey., is commonly used in traditional Chinese Medicine. Saponins are the major bioactive compounds in this herb. The similarity of polarity and structure of the natural products in herb caused the difficulty of purification and resulted in the shortage and high cost of the reference compounds, which has greatly hindered efforts toward quantification in quality control. A novel strategy using a standardized reference fraction for qualification of the major saponins in Panacis Japonici Rhizoma was proposed to easily and effectively control the quality of PJR...
November 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29186267/incidence-of-skin-diseases-diagnosed-in-a-public-institution-comparison-between-2003-and-2014
#14
Livia Maria Zanardi Miguel, Marilia Formentini Scotton Jorge, Bruna Rocha, Hélio Amante Miot
Epidemiology of diseases is influenced by population socio-demographic circumstances. Therefore it can be modified along the time. There are no studies exploring epidemiological transition in dermatology. This study investigated the incidence of dermatoses in new patients from a Brazilian country town public service in 2003 and 2014. There was a significant increase in the incidence of sexually transmitted diseases, leprosy, melasma, pruritus and hidradenitis suppurativa. However, a prominent reduction in scheduling of appointments for surgeries of benign lesions, drug reactions, urticaria and superficial mycoses was detected...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29185641/development-and-regulation-of-advanced-nurse-practitioners-in-the-uk-and-internationally
#15
Rachel King, Angela Tod, Tom Sanders
The NHS in the UK is under increasing pressure as a result of financial and recruitment issues, as well as an ageing population. Nursing has continued to adapt to this challenging time. Over the past few years, the advanced nurse practitioner (ANP) role has been implemented widely in primary and secondary care. However, the ANP role has lacked consistency in scope of practice, training and regulation. This article summarises the development of the ANP role in the UK and internationally, and issues relating to regulation...
November 29, 2017: Nursing Standard
https://www.readbyqxmd.com/read/29183831/-she-s-sort-of-breathing-what-linguistic-factors-determine-call-taker-recognition-of-agonal-breathing-in-emergency-calls-for-cardiac-arrest
#16
Marine Riou, Stephen Ball, Teresa A Williams, Austin Whiteside, Peter Cameron, Daniel M Fatovich, Gavin D Perkins, Karen Smith, Janet Bray, Madoka Inoue, Kay L O'Halloran, Paul Bailey, Deon Brink, Judith Finn
BACKGROUND: In emergency ambulance calls, agonal breathing remains a barrier to the recognition of out-of-hospital cardiac arrest (OHCA), initiation of cardiopulmonary resuscitation, and rapid dispatch. We aimed to explore whether the language used by callers to describe breathing had an impact on call-taker recognition of agonal breathing and hence cardiac arrest. METHODS: We analysed 176 calls of paramedic-confirmed OHCA, stratified by recognition of OHCA (89 cases recognised, 87 cases not recognised)...
November 26, 2017: Resuscitation
https://www.readbyqxmd.com/read/29181592/selection-and-qualification-of-simplified-qsp-models-when-using-model-order-reduction-techniques
#17
Chihiro Hasegawa, Stephen B Duffull
Quantitative systems pharmacology (QSP) models are increasingly used in drug development to provide a deep understanding of the mechanism of action of drugs and to identify appropriate disease targets. Such models are, however, not suitable for estimation purposes due to their high dimensionality. Based on any desired and specific input-output relationship, the system may be reduced to a model with fewer states and parameters. However, any simplification process will be a trade-off between model performance and complexity...
November 27, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29179850/a-nurse-led-review-of-a-child-with-asthma
#18
Ghislaine Young
Eliza is a practice nurse working in a large general practice in England. She is a trained nurse with additional qualifications in chronic disease management, and is also a registered prescriber. This means she can initiate or repeat medical prescriptions. Today Eliza is reviewing her asthma patients.
December 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/29177438/evaluating-quality-indicators-of-tertiary-care-hospitals-for-trauma-care-in-japan
#19
Shinji Nakahara, Tetsuya Sakamoto, Takashi Fujita, Yasuyuki Uchida, Yoichi Katayama, Seizan Tanabe, Yasuhiro Yamamoto
Objective: This study examined the associations between trauma mortality and quality of care indicators currently used in Japan. Design: This is a retrospective two-level discrete-time survival analysis. Quality indicators were derived from the 2012-2013 annual hospital survey conducted by the Ministry of Health, Labour and Welfare. Trauma mortality data were derived from the Japan Trauma Data Bank for the period of April 2012 to March 2013. Setting: Tertiary care centers designated as emergency and critical care centers (ECCCs) in Japan...
November 21, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29175595/the-development-of-an-instructional-video-for-the-teaching-of-acupressure-for-pain-management-in-acute-musculoskeletal-injuries-a-knowledge-translation-study
#20
Aleksandra Katarzyna Mącznik, Anthony Gerard Schneiders, Josie Athens, Stephen John Sullivan
OBJECTIVES: To survey potential stakeholders to obtain information relevant to the production of a video on teaching acupressure for sports injury management, and gain feedback from potential users on the prototype video. DESIGN: Focus groups and online survey methods nested within a knowledge translation framework. PARTICIPANTS: Four focus groups (n = 24) were conducted, two with sports medics and two with sports physiotherapists as a part of the development of a prototype video...
October 25, 2017: Physical Therapy in Sport
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