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https://www.readbyqxmd.com/read/29678531/-restructuring-of-medical-specialist-treatment-using-the-example-of-ambulatory-special-medical-care-asv-taking-a-critical-look-at-its-aims-and-implementation
#1
REVIEW
Robert Dengler, Manfred Cassens
With the GKV-VStG act in 2012, the former section 116b SGB V was transformed into ambulatory special medical care (ASV). This system comprises the diagnosis and therapy of rare or complex diseases which are difficult to treat, in need of a special qualification of doctors, an interdisciplinary cooperation and/or special facilities. For the first time, a uniform regulatory framework was established for the participation of office- as well as hospital-based doctors in ambulatory care. There is no planning of demand or licensed permission...
April 18, 2018: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29677683/application-of-solid-phase-microextraction-followed-by-liquid-chromatography-mass-spectrometry-in-the-determination-of-antibiotic-drugs-and-their-metabolites-in-human-whole-blood-and-tissue-samples
#2
Malgorzata Szultka-Mlynska, Pawel Pomastowski, Boguslaw Buszewski
A sensitive, rapid and specific analytical method using high performance liquid chromatography coupled with mass spectrometry (HPLC-QqQ-MS) was developed to determine selected antibiotic drugs and their metabolites (amoxicillin, cefotaxime, ciprofloxacin, clindamycin and metronidazole; amoxycilloic acid, 4-hydroxyphenyl glycyl amoxicillin, desacetyl cefotaxime, 3-desacetyl cefotaxime lactone, ciprofloxacin N-oxide, N-demethylclindamycin, clindamycin sulfoxide, and hydroxy metronidazole) in human whole blood and vascularized tissue after single oral administration...
April 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29676523/characterization-of-low-abundance-species-in-the-active-pharmaceutical-ingredient-of-cigb-300-a-clinical-grade-anticancer-synthetic-peptide
#3
Hilda Garay, Luis Ariel Espinosa, Yasser Perera, Aniel Sánchez, David Diago, Silvio E Perea, Vladimir Besada, Osvaldo Reyes, Luis Javier González
CIGB-300 is a first-in-class synthetic peptide-based drug of 25 amino acids currently undergoing clinical trials in cancer patients. It contains an amidated disulfide cyclic undecapeptide fused to the TAT cell-penetrating peptide through a beta-alanine spacer. CIGB-300 inhibits the CK2-mediated phosphorylation leading to apoptosis of tumor cells in vitro, and in vivo in cancer patients. Despite the clinical development of CIGB-300, the characterization of peptide-related impurities present in the active pharmaceutical ingredient has not been reported earlier...
April 20, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29675061/comorbidities-with-non-small-cell-lung-cancer-is-there-an-interdisciplinary-consensus-needed-to-qualify-patients-for-surgical-treatment
#4
Marta Lembicz, Piotr Gabryel, Beata Brajer-Luftmann, Wojciech Dyszkiewicz, Halina Batura-Gabryel
INTRODUCTION: Radical surgical treatment is the preferred action for patients with early-stage non-small cell lung cancer (NSCLC). Qualification for surgical treatment should consider a risk associated with the effect of comorbidities on the general condition of the patient. The aim of this article was an attempt to identify the risk factors for postoperative complications in patients treated for NSCLC, with a special focus on the coexisting diseases. METHODS: A total of 400 patients with NSCLC were included in this retrospective study...
April 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29674081/duality-based-direct-resolution-of-unique-profiles-using-zero-concentration-region-information
#5
Elnaz Tavakkoli, Róbert Rajkó, Hamid Abdollahi
Self Modeling Curve Resolution (SMCR) is a class of techniques concerned with estimating pure profiles underlying a set of measurements on chemical systems. In general, the estimated profiles are ambiguous (non-unique) except if some special conditions fulfilled. Implementing the adequate information can reduce the so-called rotational ambiguity effectively, and in the most desirable cases lead to the unique solution. Therefore, studies on circumstances resulting in unique solution are of particular importance...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29670861/the-cynomolgus-macaque-natural-history-model-of-pneumonic-tularemia-for-predicting-clinical-efficacy-under-the-animal-rule
#6
Tina Guina, Lynda L Lanning, Kristian S Omland, Mark S Williams, Larry A Wolfraim, Stephen P Heyse, Christopher R Houchens, Patrick Sanz, Judith A Hewitt
Francisella tularensis is a highly infectious Gram-negative bacterium that is the etiologic agent of tularemia in animals and humans and a Tier 1 select agent. The natural incidence of pneumonic tularemia worldwide is very low; therefore, it is not feasible to conduct clinical efficacy testing of tularemia medical countermeasures (MCM) in human populations. Development and licensure of tularemia therapeutics and vaccines need to occur under the Food and Drug Administration's (FDA's) Animal Rule under which efficacy studies are conducted in well-characterized animal models that reflect the pathophysiology of human disease...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29668784/double-nursing-degree-potentialities-and-challenges-of-an-international-student-academic-experience
#7
Carlise Rigon Dalla Nora, Rafaela Schaefer, Mariana Cabral Schveitzer, Elma Lourdes Campos Pavone Zoboli, Margarida Maria Vieira
Objective To share the experience of a Double Nursing degree promoted between the Nursing School of the Universidade de São Paulo and the Health Sciences Institute of the Universidade Católica Portuguesa, reflecting on the potentialities and challenges of this opportunity for graduate students. Method This is an experience report presented in chronological order and of a descriptive nature. The double degree in Nursing was accomplished over a period of 6 months in a different institution from the institution of origin...
2018: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/29666131/doctors-on-the-move-a-european-case-study-on-the-key-characteristics-of-national-recertification-systems
#8
Carolin Sehlbach, Marjan J Govaerts, Sharon Mitchell, Gernot G U Rohde, Frank W J M Smeenk, Erik W Driessen
OBJECTIVES: With increased cross-border movement, ensuring safe and high-quality healthcare has gained primacy. The purpose of recertification is to ensure quality of care through periodically attesting doctors' professional proficiency in their field. Professional migration and facilitated cross-border recognition of qualifications, however, make us question the fitness of national policies for safeguarding patient care and the international accountability of doctors. DESIGN AND SETTING: We performed document analyses and conducted 19 semistructured interviews to identify and describe key characteristics and effective components of 10 different European recertification systems, each representing one case (collective case study)...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29662606/accouchement-g%C3%A3-mellaire-en-milieu-africain-une-analyse-de-10-ans-dans-le-district-de-bamako-au-mali-twin-deliveries-in-africa-10-years-analysis-in-bamako%C3%A2-s-district-in-mali
#9
Tiounkani Théra, Niani Mounkoro, Soumana Omar Traore, Albachar Hamidou, Mamadou Traore, Saleck Doumbia, Saoudatou Tall, Aminata Kouma
Introduction Aim: It was to determine the factors influencing the prognosis of the second twin's delivery. Methods: The study was retrospective and covered all cases of twin births registered at our maternity from 1st January 2007 to 31st December 2016 (10 years). Results: We recorded 34,899 deliveries among which 1374 twin deliveries (2.54%). Almost 15% were primiparous; 39.16% were referred; 69.10% and 15.5% without prenatal care. The factors negatively influencing prognosis for second twin were: a delay>15 minutes between twin deliveries, delayed caesarean section, non-qualification of the midwife, monochoreal, low birth weight...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29662022/parental-opinions-and-attitudes-about-children-s-vaccination-safety-in-silesian-voivodeship-poland
#10
Bogumiła Braczkowska, Małgorzata Kowalska, Kamil Barański, Maksymilian Gajda, Tomasz Kurowski, Jan E Zejda
Despite mandatory vaccinations in Poland, the final decision on vaccination in children is taken by their parents or legal guardians. Understanding parents' attitudes and opinions regarding vaccinations is essential for planning and undertaking extensive and properly targeted educational actions aimed at preventing their hesitancy. In 2016, a cross-sectional study was conducted in the Silesian Voivodeship (Poland) in 11 randomly selected educational institutions. The authors' self-administered questionnaire contained 24 mixed-type questions...
April 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29652311/-inflammatory-factors-and-immunophenotypes-in-adjustment-disorders
#11
T P Klyushnik, V B Nikitina, L V Androsova, T P Vetlugina, S A Zozulya, M M Aksenov, N A Bokhan
AIM: To identify inflammatory and autoimmune markers (enzymatic activity of leukocyte elastase (LE), functional α1-proteinase inhibitor (α1-PI), the level of autoantibodies to neurospecific antigens S100b and myelin basic protein (MBP)) as well as phagocytic activity of blood neutrophils of patients with disorders of adaptation, to determine certain immunophenotypes and analyze their possible relationships with disease characteristics. MATERIAL AND METHODS: The study included 40 patients with adaptation disorders, mostly women...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29643613/medical-council-of-india-s-amended-qualifications-for-indian-medical-teachers-well-intended-yet-half-hearted
#12
EDITORIAL
Sunita Vs Bandewar, Amita Aggarwal, Rajeev Kumar, Rakesh Aggarwal, Peush Sahni, Sanjay A Pai
No abstract text is available yet for this article.
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29627314/understanding-contextual-barriers-and-enablers-to-pressure-injury-prevention-practice-in-an-australian-intensive-care-unit-an-exploratory-study
#13
Fiona Coyer, Jane-Louise Cook, Anna Doubrovsky, Jill Campbell, Amanda Vann, Greg McNamara
BACKGROUND: Skin integrity management is often a low clinical priority in the intensive care environment, possibly resulting in high pressure injury (PI) prevalence. This article reports the results of the first phase of a multiphased project, "Translating evidence-based pressure injury prevention strategies to the intensive care environment (SUSTAIN study)". The SUSTAIN study used a research translation framework to guide the assessment of research uptake, development, and monitoring of translational strategies to reduce PIs...
April 4, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29626532/container-closure-integrity-testing-of-prefilled-syringes
#14
Sarah S Peláez, Hanns-Christian Mahler, Anja Matter, Atanas Koulov, Satish K Singh, Oliver Germershaus, Roman Mathaes
Prefilled syringes (PFSs) are increasingly preferred over vials as container closure systems (CCSs) for injectable drug products when facilitated or self-administration is required. However, PFSs are more complex compared to CCSs consisting of vial, rubber stopper and crimp cap. Container closure integrity (CCI) assurance and verification has been a specific challenge for PFSs as they feature several sealing areas. A comprehensive understanding of the CCS is necessary for an appropriate CCI assessment as well as for packaging development and qualification...
April 4, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29626121/reproducibility-and-repeatability-of-semi-quantitative-18-f-fluorodihydrotestosterone-fdht-uptake-metrics-in-castration-resistant-prostate-cancer-metastases-a-prospective-multi-center-study
#15
Hebert Alberto Vargas, Gem M Kramer, Andrew M Scott, Andrew Weickhardt, Andreas A Meier, Nicole Parada, Bradley J Beattie, John L Humm, Kevin D Staton, Pat B Zanzonico, Serge K Lyashchenko, Jason S Lewis, Maqsood Yaqub, Ramon E Sosa, Alfons J van den Eertwegh, Ian D Davis, Uwe Ackermann, Kunthi Pathmaraj, Robert C Schuit, Albert D Windhorst, Sue Chua, Wolfgang A Weber, Steven M Larson, Howard I Scher, Adriaan A Lammertsma, Otto Hoekstra, Michael J Morris
18 F-fluorodihydrotestosterone (18 F-FDHT) is a radiolabeled analogue of the androgen receptor's primary ligand that is currently being credentialed as a biomarker for prognosis, response, and pharmacodynamic effects of new therapeutics. As part of the biomarker qualification process, we prospectively assessed its reproducibility and repeatability in men with metastatic castration-resistant prostate cancer (mCRPC). Methods: We conducted a prospective multi-institutional study of mCRPC patients undergoing two (test/re-test)18 F-FDHT PET/CT scans on two consecutive days...
April 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29625566/passing-mrcp-uk-paces-a-cross-sectional-study-examining-the-performance-of-doctors-by-sex-and-country
#16
Emily Unwin, Henry W W Potts, Jane Dacre, Andrew Elder, Katherine Woolf
BACKGROUND: There is much discussion about the sex differences that exist in medical education. Research from the United Kingdom (UK) and United States has found female doctors earn less, and are less likely to be senior authors on academic papers, but female doctors are also less likely to be sanctioned, and have been found to perform better academically and clinically. It is also known that international medical graduates tend to perform more poorly academically compared to home-trained graduates in the UK, US, and Canada...
April 6, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29623095/understanding-unlicensed-drug-vendor-practices-related-to-childhood-malaria-in-one-rural-district-of-uganda-an-exploratory-study
#17
Eric Liow, Rosemin Kassam, Richard Sekiwunga
This study investigated unlicensed drug outlets' practices for the management of malaria in the rural district of Butaleja, Uganda. A qualitative design using semistructured interviews was used. Interviews were recorded, translated, transcribed, and analyzed using thematic analysis. A total of 75 vendors, representing 85% of the outlets in the study area, were interviewed. Most of the vendors were associated with a drug shop type of outfit. About three-quarters reported having completed some level of postsecondary education, but just one-tenth of the vendors had qualifications that made them eligible to apply for a license to operate a drug shop...
2018: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29621995/labour-force-participation-and-the-cost-of-lost-productivity-due-to-cancer-in-australia
#18
Nicole Bates, Emily Callander, Daniel Lindsay, Kerrianne Watt
BACKGROUND: In Australia, 40% of people diagnosed with cancer will be of working age (25-64 years). A cancer diagnosis may lead to temporary or permanent changes in a person's labour force participation, which has an economic impact on both the individual and the economy. However, little is known about this economic impact of cancer due to lost productivity in Australia. This paper aims to determine the labour force participation characteristics of people with cancer, to estimate the indirect cost due to lost productivity, and to identify any inequality in the distribution of labour force absence in Australia...
April 6, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29620971/benefits-and-barriers-to-telehealth-credentialing-by-proxy
#19
Annalise Baker-Whitcomb, Jillian Harvey
BACKGROUND: Medical staff credentialing is the time-intensive process of verifying a provider's qualifications before granting privileges within a hospital. This process creates a large administrative barrier for telehealth services, as a large number of providers must be credentialed at each participating originating site within a telehealth network. INTRODUCTION: Despite the availability of a streamlined telehealth credentialing method called Credentialing by Proxy (CBP), a significant number of hospitals still opt for traditional credentialing...
March 13, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29619370/an-original-approach-to-evaluating-the-quality-of-blood-donor-selection-checking-donor-questionnaires-and-analyzing-donor-deferral-rate
#20
Philippe Gillet, Esther Neijens
Blood donor selection is a cornerstone for blood transfusion safety, designed to safeguard the health of both donors and recipients. In the Service du Sang, Belgian Red Cross, French and German-speaking part of Belgium (SFS), health professionals (HPs) are allowed to interview donors on their own after formal qualification. This qualification is afterward evaluated by means of two complementary quality indicators: monitoring of donor health questionnaires (DHQs) and analysis of donor deferral rate. The study aims to evaluate the degree to which both quality indicators may be useful and appropriate tools to evaluate the quality of blood donor selection...
2018: Frontiers in Medicine
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