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https://www.readbyqxmd.com/read/29353455/the-interplay-between-apolipoprotein-e4-and-the-autophagic-endocytic-lysosomal-axis
#1
REVIEW
E Schmukler, D M Michaelson, R Pinkas-Kramarski
Since its discovery as a genetic risk factor for Alzheimer's disease, the APOE4 allele has been linked to the majority of the pathological findings associated with the disease progression. These include abnormalities of the endocytic, autophagic, and lysosomal machineries, which begin at the most early stages of Alzheimer's disease development. Considering that these three vesicular systems share common features and, in fact, comprise an interconnected cargo-trafficking and degradation network, some of the effects of APOE4 are interrelated, while others are system-specific...
January 20, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29353444/mortality-is-rare-following-elective-and-non-elective-surgery-for-ulcerative-colitis-but-mild-postoperative-complications-are-common
#2
Joseph D Feuerstein, Thomas Curran, Michael Alosilla, Thomas Cataldo, Kenneth R Falchuk, Vitaliy Poylin
BACKGROUND DATA: Currently, data regarding the rates of morbidity and mortality following non-elective colectomy for ulcerative colitis (UC) are variable. We sought to determine the rates and predictors of 90-day mortality and complications following colectomy for UC. METHODS: Patients undergoing an initial surgery for UC at a tertiary care center between January 2002 and January 2014 were included. Patients were identified using ICD-9 code 556.x. Each record was manually reviewed for demographic information, medical histories, UC history, medications, and data regarding the admission and discharge...
January 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29353388/outcomes-and-cost-effectiveness-of-ultrasound-guided-injection-of-the-trochanteric-bursa
#3
William G Mitchell, Sharon C Kettwich, Wilmer L Sibbitt, Randy R Sibbitt, Maheswari Muruganandam, Noelle A Rolle, William A Hayward, Roderick A Fields, Luis P Roldan, N Suzanne Emil, Monthida Fangtham, Arthur D Bankhurst
We hypothesized that ultrasound (US) guidance improves outcomes of corticosteroid injection of trochanteric bursitis. 40 patients with greater trochanteric pain syndrome defined by pain to palpation over the trochanteric bursa were randomized to injection with 5 ml of 1% lidocaine and 80 mg of methylprednisolone using (1) conventional anatomic landmark palpation guidance or (2) US guidance. Procedural pain (Visual Analogue Pain Scale), pain at outcome (2 weeks and 6 months), therapeutic duration, time-to-next intervention, and costs were determined...
January 20, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29353379/coagulase-negative-staphylococci-are-associated-to-the-mild-inflammatory-pattern-of-healthcare-associated-meningitis-a-retrospective-study
#4
S Couffin, D Lobo, F Cook, P H Jost, V Bitot, R Birnbaum, B Nebbad, B Aït-Mamar, W Lahiani, M Martin, G Dhonneur, R Mounier
The epidemiology of healthcare-associated meningitis (HAM) is dominated by commensal bacteria from the skin, as coagulase-negative staphylococci (CoNS). We hypothesized that the pauci-symptomatic and mild inflammatory patterns of HAM are related to the low pathogenic state of CoNS. Our aim was to describe clinical and biological features of CoNS HAM, compared to other HAM. All consecutive patients with HAM admitted in our hospital were retrospectively included from 2007 to 2014. HAM due to CoNS were compared to HAM caused by other bacteria (controls) for clinical and laboratory patterns...
January 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29353163/time-interval-between-neoadjuvant-chemoradiotherapy-and-surgery-for-oesophageal-or-junctional-cancer-a-nationwide-study
#5
L R van der Werf, J L Dikken, E M van der Willik, M I van Berge Henegouwen, G A P Nieuwenhuijzen, B P L Wijnhoven
INTRODUCTION: The optimal time between end of neoadjuvant chemoradiotherapy (nCRT) and oesophagectomy is unknown. The aim of this study was to assess the association between this interval and pathologic complete response rate (pCR), morbidity and 30-day/in-hospital mortality. METHODS: Patients with oesophageal cancer treated with nCRT and surgery between 2011 and 2016 were selected from a national database: the Dutch Upper Gastrointestinal Cancer Audit (DUCA). The interval between end of nCRT and surgery was divided into six periods: 0-5 weeks (n = 157;A), 6-7 weeks (n = 878;B), 8-9 weeks (n = 972;C), 10-12 weeks (n = 720;D), 13-14 weeks (n = 195;E) and 15 or more weeks (n = 180;F)...
January 17, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29353144/effects-of-the-hdac-inhibitor-scriptaid-on-the-in%C3%A2-vitro-development-of-bovine-embryos-and-on-imprinting-gene-expression-levels
#6
R Laguna-Barraza, M J Sánchez-Calabuig, A Gutiérrez-Adán, D Rizos, S Pérez-Cerezales
This study examines the effects of the histone deacetylation inhibitor scriptaid (SCR) on preimplantation embryo development in vitro and on imprinting gene expression. We hypothesized that SCR would increase histone acetylation levels, enhance embryonic genome activation, and regulate imprinting and X-chromosome inactivation (XCI) in in vitro produced bovine embryos. Zygotes were cultured in vitro in presence or absence of SCR added at different time points. We assessed cleavage and blastocyst rates as well as the quality of blastocysts through: (i) differential cell counts; (ii) survival after vitrification/thawing and (iii) gene expression analysis -including imprinted genes...
January 11, 2018: Theriogenology
https://www.readbyqxmd.com/read/29353127/physical-comorbidities-increase-the-risk-of-psychiatric-comorbidity-in-immune-mediated-inflammatory-disease
#7
Ruth Ann Marrie, Randy Walld, James M Bolton, Jitender Sareen, John R Walker, Scott B Patten, Alexander Singer, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, Alan Katz, John D Fisk, Charles N Bernstein
OBJECTIVE: We tested the association between physical comorbidity and incident depression, anxiety disorder and bipolar disorder in three immune-mediated inflammatory diseases (IMID): inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA) versus age-, sex- and geographically-matched controls. METHODS: Using population-based administrative data we identified 6119 persons with IBD, 3514 persons with MS, 10,206 persons with RA and 97,727 matched controls...
January 11, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29353082/3d-extrusion-printing-of-high-drug-loading-immediate-release-paracetamol-tablets
#8
Shaban A Khaled, Morgan R Alexander, Ricky D Wildman, Martin J Wallace, Sonja Sharpe, Jae Yoo, Clive J Roberts
The manufacture of immediate release high drug loading paracetamol oral tablets was achieved using an extrusion based 3D printer from a premixed water based paste formulation. The 3D printed tablets demonstrate that a very high drug (paracetamol) loading formulation (80% w/w) can be printed as an acceptable tablet using a method suitable for personalisation and distributed manufacture. Paracetamol is an example of a drug whose physical form can present challenges to traditional powder compression tableting...
January 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29353048/cardiac-events-after-non-cardiac-surgery-in-patients-undergoing-pre-operative-dobutamine-stress-echocardiography-findings-from-the-mayo-poce-dse-investigators
#9
R Jay Widmer, Michael W Cullen, Bradley R Salonen, Karna K Sundsted, David Raslau, Arya B Mohabbat, Brian M Dougan, D Mike Bierle, Donna K Lawson, A Jimmy Widmer, Mary Bundrick, Prakriti Gaba, Rene Tellez, Darrell R Schroeder, Robert B McCully, Karen F Mauck
BACKGROUND: Current guidelines support the use of dobutamine stress echocardiography (DSE) prior to non-cardiac surgery in higher risk patients who are unable to perform at least 4 metabolic equivalents of physical activity. We evaluated post-operative outcomes of patients in different operative risk categories after pre-operative DSE. METHODS: We collected data from the medical record on 4,494 patients from January 1, 2006 to December 31, 2011 who had DSE up to 90 days prior to a non-cardiac surgery...
January 15, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29352878/in-vitro-fermentation-of-cookeina-speciosa-glucans-stimulates-the-growth-of-the-butyrogenic-clostridium-cluster-xiva-in-a-targeted-way
#10
Thaisa Moro Cantu-Jungles, Andrea Caroline Ruthes, Marwa El-Hindawy, Roberta Barbara Moreno, Xiaowei Zhang, Lucimara M C Cordeiro, Bruce R Hamaker, Marcello Iacomini
Dietary fiber chemical and physical structures may be critical to the comprehension of how they may modulate gut bacterial composition. We purified insoluble polymers from Cookeina speciosa, and investigated its fermentation profile in an in vitro human fecal fermentation model. Two glucans, characterized as a (1 → 3),(1 → 6)-linked and a (1→3)-linked β-D-glucans were obtained. Both glucans were highly butyrogenic and propiogenic, with low gas production, during in vitro fecal fermentation and led to distinct bacterial shifts if compared to fructooligosaccharides...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352828/sensitivity-of-fatty-acid-desaturation-and-elongation-to-plasma-zinc-concentration-a-randomised-controlled-trial-in-beninese-children
#11
Tsitsi Chimhashu, Linda Malan, Jeannine Baumgartner, Paul J van Jaarsveld, Valeria Galetti, Diego Moretti, Cornelius M Smuts, Michael B Zimmermann
Zn status may affect fatty acid (FA) metabolism because it acts as a cofactor in FA desaturase and elongase enzymes. Zn supplementation affects the FA desaturases of Zn-deficient rats, but whether this occurs in humans is unclear. We evaluated the associations between baseline plasma Zn (PZn) concentration and plasma total phospholipid FA composition, as well as the effect of daily consumption of Zn-fortified water on FA status in Beninese children. A 20-week, double-blind randomised controlled trial was conducted in 186 school age children...
January 21, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29352789/hydrodynamic-relaxations-in-dissipative-particle-dynamics
#12
J S Hansen, Michael L Greenfield, Jeppe C Dyre
This paper studies the dynamics of relaxation phenomena in the standard dissipative particle dynamics (DPD) model [R. D. Groot and P. B. Warren, J. Chem. Phys. 107, 4423 (1997)]. Using fluctuating hydrodynamics as the framework of the investigation, we focus on the collective transverse and longitudinal dynamics. It is shown that classical hydrodynamic theory predicts the transverse dynamics at relatively low temperatures very well when compared to simulation data; however, the theory predictions are, on the same length scale, less accurate for higher temperatures...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352698/gastric-varices-bleed-at-lower-portosystemic-pressure-gradients-than-esophageal-varices
#13
Joseph D Morrison, Nasya Mendoza-Elias, Andrew J Lipnik, R Peter Lokken, James T Bui, Charles E Ray, Ron C Gaba
PURPOSE: To quantify and compare portosystemic pressure gradients (PSGs) between bleeding esophageal varices (EV) and gastric varices (GV). MATERIALS AND METHODS: In a single-center, retrospective study, 149 patients with variceal bleeding (90 men, 59 women, mean age 52 y) with EV (n = 69; 46%) or GV (n = 80; 54%) were selected from 320 consecutive patients who underwent successful transjugular intrahepatic portosystemic shunt (TIPS) creation from 1998 to 2016...
January 15, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29352623/effect-of-method-of-anesthesia-on-the-reproductive-and-obstetric-outcomes-of-heterotopic-pregnancies
#14
F Liu, Y F Liu, J Liu, Y Huang, G F Xu, J Cai, Y Chen, Y Q Wu, Y Y Ying, R J Zhang, D Zhang
BACKGROUND: Anesthesia is commonly used for surgical termination of the extrauterine component of heterotopic pregnancy. We sought to evaluate the effects of general and regional anesthesia during salpingectomy on reproductive and obstetric outcomes of heterotopic pregnancies. METHODS: A two-center, retrospective cohort study was conducted, and 49 heterotopic pregnancies were included. Baseline characteristics, reproductive and obstetric outcomes were compared between the general anesthesia and regional anesthesia groups...
December 7, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29352562/cbs-mutations-are-good-predictors-for-b6-responsiveness-a-study-based-on-the-analysis-of-35-brazilian-classical-homocystinuria-patients
#15
Soraia Poloni, Fernanda Sperb-Ludwig, Taciane Borsatto, Giovana Weber Hoss, Maria Juliana R Doriqui, Emília K Embiruçu, Ney Boa-Sorte, Charles Marques, Chong A Kim, Carolina Fischinger Moura de Souza, Helio Rocha, Marcia Ribeiro, Carlos E Steiner, Carolina A Moreno, Pricila Bernardi, Eugenia Valadares, Osvaldo Artigalas, Gerson Carvalho, Hector Y C Wanderley, Johanna Kugele, Melanie Walter, Lorena Gallego-Villar, Henk J Blom, Ida Vanessa D Schwartz
BACKGROUND: Classical homocystinuria (HCU) is a monogenic disease caused by the deficient activity of cystathionine β-synthase (CβS). The objective of this study was to identify the CBS mutations in Brazilian patients with HCU. METHODS: gDNA samples were obtained for 35 patients (30 families) with biochemically confirmed diagnosis of HCU. All exons and exon-intron boundaries of CBS gene were sequenced. Gene expression analysis by qRT-PCR was performed in six patients...
January 20, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29352526/ectrims-ean-guideline-on-the-pharmacological-treatment-of-people-with-multiple-sclerosis
#16
X Montalban, R Gold, A J Thompson, S Otero-Romero, M P Amato, D Chandraratna, M Clanet, G Comi, T Derfuss, F Fazekas, H P Hartung, E Havrdova, B Hemmer, L Kappos, R Liblau, C Lubetzki, E Marcus, D H Miller, T Olsson, S Pilling, K Selmaj, A Siva, P S Sorensen, M P Sormani, C Thalheim, H Wiendl, F Zipp
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a complex disease of the central nervous system. As new drugs are becoming available, knowledge on diagnosis and treatment must continuously evolve. There is therefore a need for a reference tool compiling current data on benefit and safety, to aid professionals in treatment decisions and use of resources across Europe. The European Committee of Treatment and Research in Multiple Sclerosis (ECTRIMS) and the European Academy of Neurology (EAN) have joined forces to meet this need...
January 19, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29352512/trpv1-antagonists-that-cause-hypothermia-instead-of-hyperthermia-in-rodents-compounds-pharmacological-profiles-in-vivo-targets-thermoeffectors-recruited-and-implications-for-drug-development
#17
Andras Garami, Eszter Pakai, Heath A McDonald, Regina M Reilly, Arthur Gomtsyan, Joshua J Corrigan, Erika Pinter, Dawn X D Zhu, Sonya G Lehto, Narender R Gavva, Philip R Kym, Andrej A Romanovsky
AIM: Thermoregulatory side effects hinder the development of transient receptor potential vanilloid-1 (TRPV1) antagonists as new painkillers. While many antagonists cause hyperthermia, a well-studied effect, some cause hypothermia. The mechanisms of this hypothermia are unknown and were studied herein. METHODS: Two hypothermia-inducing TRPV1 antagonists, the newly synthesized A-1165901 and the known AMG7905, were used in physiological experiments in rats and mice...
January 20, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29352510/identification-of-a-novel-hla-c-12-allele-hla-c-12-221
#18
M-R Huo, Y Yu, B Xi, D Li
HLA-C*12:221 differs from C*12:02:03 by a single nucleotide substitution at position 367 of exon 3.
January 20, 2018: HLA
https://www.readbyqxmd.com/read/29352495/ultrasonographic-based-predictive-factors-influencing-successful-return-to-racing-after-superficial-digital-flexor-tendon-injuries-in-flat-racehorses-a-retrospective-cohort-study-in-469-thoroughbred-racehorses-in-hong-kong
#19
R Alzola, C Easter, C M Riggs, D S Gardner, S L Freeman
BACKGROUND: Superficial digital flexor tendon (SDFT) injury is an important health and welfare concern in racehorses. It is generally diagnosed with ultrasonography, predictive ultrasonographic features have not been reported. OBJECTIVES: To determine ultrasonographic features of forelimb SDFT injury at initial presentation in Thoroughbred racehorses, that could predict a successful return to racing (completing ≥5 races). STUDY DESIGN: Retrospective cohort study...
January 20, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29352453/measuring-surgical-safety-during-minimally-invasive-surgical-procedures-a-validation-study
#20
Mathijs D Blikkendaal, Sara R C Driessen, Sharon P Rodrigues, Johann P T Rhemrev, Maddy J G H Smeets, Jenny Dankelman, John J van den Dobbelsteen, Frank Willem Jansen
BACKGROUND: During the implementation of new interventions (i.e., surgical devices and technologies) in the operating room, surgical safety might be compromised. Current safety measures are insufficient in detecting safety hazards during this process. The aim of the study was to observe whether surgical teams are capable of measuring surgical safety, especially with regard to the introduction of new interventions. METHODS: A Surgical Safety Questionnaire was developed that had to be filled out directly postoperative by three surgical team members...
January 19, 2018: Surgical Endoscopy
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