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https://www.readbyqxmd.com/read/28927211/a-pivotal-randomized-clinical-trial-evaluating-the-safety-and-effectiveness-of-a-novel-hydrogel-dural-sealant-as-an-adjunct-to-dural-repair
#1
Michael J Strong, G Alexander West, Henry Woo, Daniel E Couture, John A Wilson, Lorenzo F Munoz, Charles L Rosen, Jeremy D Greenlee, Harry R van Loveren, Mark Iantosca, Clinton J Baird, Mark Smith, Matt McGirt, Jonathan Parish, Anthony L Asher
BACKGROUND: A watertight dural repair is critical to minimizing the risk of postoperative complications secondary to cerebrospinal fluid (CSF) leaks. OBJECTIVE: To evaluate the safety and efficacy of a novel hydrogel, Adherus Dural Sealant, when compared with control, DuraSeal Dural Sealant System, as an adjunct to standard methods of dural repair. METHODS: In this 17-center, prospective, randomized clinical trial designed as a noninferiority, single-blinded study, 124 patients received Adherus Dural Sealant (test sealant) and 126 received DuraSeal (control)...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28927202/role-of-molecular-biomarkers-in-the-diagnosis-of-invasive-fungal-diseases-in-children
#2
Anna R Huppler, Brian T Fisher, Thomas Lehrnbecher, Thomas J Walsh, William J Steinbach
Invasive fungal diseases are important clinical problems that are often complicated by severe illness and therefore the inability to use invasive measures to definitively diagnose the disease. Tests for a range of fungal biomarkers that do not require an invasive sample-collection procedure have been incorporated into adult clinical practice, but pediatric data and pediatric-specific recommendations for some of these diagnostic tools are lacking. In this review, we summarize the published literature and contemporary strategies for using the biomarkers galactomannan, (1→3)-β-d-glucan, Candida mannan antigen and anti-mannan antibody, and fungal polymerase chain reaction for diagnosing invasive fungal disease in children...
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28926884/-a-study-on-the-diagnostic-value-of-tear-film-objective-scatter-index-in-dry-eye
#3
Y D Su, Q F Liang, N L Wang, Labbè Antoine
Objective: To study the sensitivity and specificity of tear film objective scatter index to the diagnosis dry eye disease (DED). Methods: A prospective case-controlled study. Fifty-three patients with DED and 32 healthy age- and sex-matched control subjects were included from July to October 2016. All subjects underwent the examinations sequentially as follows: evaluation of ocular surface disease symptoms using the Ocular Surface Disease Index, optical quality detection, lipid layer thickness, tear film breakup time and SchirmerⅠtest...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28926618/teneurin-2-presence-in-rat-and-human-odontoblasts
#4
K R Torres-da-Silva, G W L Tessarin, C A Dias, I Z Guiati, E Ervolino, A Gonçalves, I M Beneti, D A Lovejoy, C A Casatti
Teneurins are transmembrane proteins consisting of four paralogues (Ten-1-4), notably expressed in the central nervous system during development. All teneurins contain a bioactive peptide in their carboxyl terminal named teneurin C-terminal associated peptide (TCAP). The present study analyzed the detailed distribution of teneurin-2-like immunoreactive (Ten-2-LI) cells in developing and mature rat molar teeth, as well as in mature human dental pulps. Ten-2 and TCAP-2 genic expressions were also evaluated in rat and human dental pulps...
2017: PloS One
https://www.readbyqxmd.com/read/28926611/activation-of-the-unfolded-protein-response-in-sarcoma-cells-treated-with-rapamycin-or-temsirolimus
#5
Joseph W Briggs, Ling Ren, Kristi R Chakrabarti, Yien Che Tsai, Allan M Weissman, Ryan J Hansen, Daniel L Gustafson, Yousuf A Khan, Jonathan D Dinman, Chand Khanna
Activation of the unfolded protein response (UPR) in eukaryotic cells represents an evolutionarily conserved response to physiological stress. Here, we report that the mTOR inhibitors rapamycin (sirolimus) and structurally related temsirolimus are capable of inducing UPR in sarcoma cells. However, this effect appears to be distinct from the classical role for these drugs as mTOR inhibitors. Instead, we detected these compounds to be associated with ribosomes isolated from treated cells. Specifically, temsirolimus treatment resulted in protection from chemical modification of several rRNA residues previously shown to bind rapamycin in prokaryotic cells...
2017: PloS One
https://www.readbyqxmd.com/read/28926530/erratum-the-microrna-mir-31-inhibits-cd8-t-cell-function-in-chronic-viral-infection
#6
Howell F Moffett, Adam N R Cartwright, Hye-Jung Kim, Jernej Godec, Jason Pyrdol, Tarmo Äijö, Gustavo J Martinez, Anjana Rao, Jun Lu, Todd R Golub, Harvey Cantor, Arlene H Sharpe, Carl D Novina, Kai W Wucherpfennig
No abstract text is available yet for this article.
September 19, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28926502/limbal-cysts-a-subset-exhibiting-cornea-specific-cytokeratins
#7
Norman C Charles, Frederick A Jakobiec, Fouad R Zakka, Ilyse D Haberman, Kishore Reddy Katikireddy, Ula V Jurkunas
Two cases of limbal cysts lined by nonkeratinizing epithelium were studied with a panel of cytokeratins. One was a long-standing lesion in a 30-year-old man, whereas the other was excised from a 40-year-old man following pterygium surgery. Each cyst was immunostained with a panel of cytokeratins that were specific exclusively and separately for corneal and conjunctival epithelia. The epithelial lining of each cyst was CK12 positive for corneal epithelium and CK13 negative for conjunctival epithelium. It is hypothesized that a subset of corneoscleral cysts contain corneal epithelium, probably derived from a type of limbal stem cell differentiation...
September 13, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28926412/endoscopic-ultrasound-and-related-technologies-for-the-diagnosis-and-treatment-of-pancreatic-disease-research-gaps-and-opportunities-summary-of-a-national-institute-of-diabetes-and-digestive-and-kidney-diseases-workshop
#8
Linda S Lee, Dana K Andersen, Reiko Ashida, William R Brugge, Mimi I Canto, Kenneth J Chang, Suresh T Chari, John DeWitt, Joo Ha Hwang, Mouen A Khashab, Kang Kim, Michael J Levy, Kevin McGrath, Walter G Park, Aatur Singhi, Tyler Stevens, Christopher C Thompson, Mark D Topazian, Michael B Wallace, Sachin Wani, Irving Waxman, Dhiraj Yadav, Vikesh K Singh
A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to address the research gaps and opportunities in pancreatic endoscopic ultrasound (EUS). The event occurred on July 26, 2017 in 4 sessions: (1) benign pancreatic diseases, (2) high-risk pancreatic diseases, (3) diagnostic and therapeutics, and (4) new technologies. The current state of knowledge was reviewed, with identification of numerous gaps in knowledge and research needs. Common themes included the need for large multicenter consortia of various pancreatic diseases to facilitate meaningful research of these entities; to standardize EUS features of different pancreatic disorders, the technique of sampling pancreatic lesions, and the performance of various therapeutic EUS procedures; and to identify high-risk disease early at the cellular level before macroscopic disease develops...
September 18, 2017: Pancreas
https://www.readbyqxmd.com/read/28926360/relationship-of-vitamin-d-and-parathyroid-hormone-with-the-nocturnal-blood-pressure-decline-in-hypertension
#9
Makbule K Karadag, Ozlem Secen
OBJECTIVES: Vitamin D deficiency and high parathyroid hormone (PTH) levels have been linked with hypertension. Nondipper hypertension is associated with increased morbidity and mortality. We aimed to investigate the relationship of vitamin D and PTH levels with nondipper hypertension and nocturnal decline in untreated hypertensive patients. PATIENTS AND METHODS: This cross-sectional study included a total of 73 hypertensive and 34 normotensive participants. Each patient underwent 24-hour ambulatory blood pressure monitoring, routine biochemical tests, vitamin D, and PTH analysis...
September 18, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28926305/structural-relationships-among-the-revised-reinforcement-sensitivity-theory-and-grandiose-and-vulnerable-narcissism
#10
Christopher C Spencer, Joshua D Foster, Jeffrey S Bedwell
Research shows that grandiosity and vulnerability are distinct aspects of narcissism. The Contemporary Clinical Model (CCM) of narcissism suggests that individuals fluctuate between grandiose narcissism (GN) and vulnerable narcissism (VN). The authors examine the relative contributions of the Behavioral Approach System (BAS), the Behavioral Inhibition System (BIS), and the Fight-Flight-Freeze System (FFFS) in the Revised Reinforcement Sensitivity Theory of Personality (r-RST) to GN and VN. Few studies examine the r-RST, and even fewer examine the VN and GN distinction...
September 19, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28926020/animal-health-economics-an-aid-to-decisionmaking-on-animal-health-interventions-case-studies-in-the-united-states-of-america
#11
T L Marsh, D Pendell, R Knippenberg
For animal disease events the outcomes and consequences often remain unclear or uncertain, including the expected changes in benefits (e.g. profit to firms, prices to consumers) and in costs (e.g. response, clean-up). Moreover, the measurement of changes in benefits and costs across alternative interventions used to control animal disease events may be inexact. For instance, the economic consequences of alternative vaccination strategies to mitigate a disease can vary in magnitude due to trade embargoes and other factors...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28926011/the-economic-impact-of-peste-des-petits-ruminants-in-india
#12
D Bardhan, S Kumar, G Anandsekaran, J K Chaudhury, M Meraj, R K Singh, M R Verma, D Kumar, N Kumar P T, S Ahmed Lone, V Mishra, B S Mohanty, N Korade, U K De
Peste des petits ruminants (PPR) is an economically important livestock disease which affects a vast section of the small ruminant population in India. However, data on the incidence of PPR are limited and scant literature is available on the economic losses caused by the disease. In the present study, a structured sampling design was adopted, which covered the major agro-climatic regions of the country, to ascertain the morbidity and mortality rates of PPR. Available estimates of the economic losses in India due to various livestock diseases are based on single values of various epidemiological and economic parameters...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28926003/age-of-first-exposure-to-american-football-and-long-term-neuropsychiatric-and-cognitive-outcomes
#13
M L Alosco, A B Kasimis, J M Stamm, A S Chua, C M Baugh, D H Daneshvar, C A Robbins, M Mariani, J Hayden, S Conneely, R Au, A Torres, M D McClean, A C McKee, R C Cantu, J Mez, C J Nowinski, B M Martin, C E Chaisson, Y Tripodis, R A Stern
Previous research suggests that age of first exposure (AFE) to football before age 12 may have long-term clinical implications; however, this relationship has only been examined in small samples of former professional football players. We examined the association between AFE to football and behavior, mood and cognition in a large cohort of former amateur and professional football players. The sample included 214 former football players without other contact sport history. Participants completed the Brief Test of Adult Cognition by Telephone (BTACT), and self-reported measures of executive function and behavioral regulation (Behavior Rating Inventory of Executive Function-Adult Version Metacognition Index (MI), Behavioral Regulation Index (BRI)), depression (Center for Epidemiologic Studies Depression Scale (CES-D)) and apathy (Apathy Evaluation Scale (AES))...
September 19, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28926001/ketamine-differential-neurophysiological-dynamics-in-functional-networks-in-the-rat-brain
#14
A Ahnaou, H Huysmans, R Biermans, N V Manyakov, W H I M Drinkenburg
Recently, the N-methyl-d-aspartate-receptor (NMDAR) antagonist ketamine has emerged as a fast-onset mechanism to achieve antidepressant activity, whereas its psychomimetic, dissociative and amnestic effects have been well documented to pharmacologically model schizophrenia features in rodents. Sleep-wake architecture, neuronal oscillations and network connectivity are key mechanisms supporting brain plasticity and cognition, which are disrupted in mood disorders such as depression and schizophrenia. In rats, we investigated the dynamic effects of acute and chronic subcutaneous administration of ketamine (2...
September 19, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28925999/an-evaluation-of-the-effects-of-intensity-and-duration-on-outcomes-across-treatment-domains-for-children-with-autism-spectrum-disorder
#15
E Linstead, D R Dixon, E Hong, C O Burns, R French, M N Novack, D Granpeesheh
Applied behavior analysis (ABA) is considered an effective treatment for individuals with autism spectrum disorder (ASD), and many researchers have further investigated factors associated with treatment outcomes. However, few studies have focused on whether treatment intensity and duration have differential influences on separate skills. The aim of the current study was to investigate how treatment intensity and duration impact learning across different treatment domains, including academic, adaptive, cognitive, executive function, language, motor, play, and social...
September 19, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28925738/psychometric-properties-of-the-saint-louis-university-mental-status-examination
#16
Susan K Shwartz, Robin D Morris, Suzanne Penna
The Saint Louis University Mental Status (SLUMS) Examination is a brief screening measure for mild neurocognitive disorder developed for use with veterans. To date, there has been a paucity of research on its psychometric properties. The purpose of this study is to evaluate the psychometric properties of the SLUMS in a referred sample to a specialty clinic. Using a sample of 148 male veterans referred to a Mild Cognitive Impairment (MCI) Clinic for evaluation, the ability of the SLUMS to discriminate between MCI versus Major Depressive Disorder (MDD) or no diagnosis was compared to results from a more comprehensive neuropsychological battery...
September 19, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28925710/highly-localized-strain-in-a-mos2-au-heterostructure-revealed-by-tip-enhanced-raman-spectroscopy
#17
Mahfujur Rahaman, Raul D Rodriguez, Gerd Plechinger, Stefan Moras, Christian Schüller, Tobias Korn, Dietrich R T Zahn
Tip-enhanced Raman spectroscopy (TERS) has been rapidly improved over the last decade and opened up opportunities to study phonon properties of materials at the nanometer scale. In this contribution we report on tip-enhanced Raman spectroscopy (TERS) of an ultra-thin MoS2 flake on a nanostructured Au on silicon surface forming a two-dimensional (2D) crystal/plasmonic heterostructure. Au nanostructures (shaped in triangles) are prepared by nanosphere lithography and then MoS2 is mechanically exfoliated on top of them...
September 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/28925647/aseptic-and-bacterial-meningitis-evaluation-treatment-and-prevention
#18
Hillary R Mount, Sean D Boyle
The etiologies of meningitis range in severity from benign and self-limited to life-threatening with potentially severe morbidity. Bacterial meningitis is a medical emergency that requires prompt recognition and treatment. Mortality remains high despite the introduction of vaccinations for common pathogens that have reduced the incidence of meningitis worldwide. Aseptic meningitis is the most common form of meningitis with an annual incidence of 7.6 per 100,000 adults. Most cases of aseptic meningitis are viral and require supportive care...
September 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28925586/haemopref-further-evaluation-of-patient-perception-and-preference-for-treatment-in-a-real-world-setting
#19
S Bonanad, M Schulz, A Gordo, D Spurden, M Cicchetti, J C Cappelleri, C Tolley, H Staunton, E Brohan
INTRODUCTION: Adherence to haemophilia A (HA) treatment may be influenced by patients' beliefs about their condition and treatment. Furthermore, difficulties administering treatment may lead to poor adherence. New treatment strategies aim to reduce the burden associated with administration and to improve patient perception of treatment, which, in turn, increase adherence levels. AIMS: This study aimed to examine patient perception of HA treatment and related factors using patient-reported outcome (PRO) questionnaires and to confirm the psychometric properties of a recently developed questionnaire, the HaemoPREF...
September 19, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28925585/resemblance-in-physical-activity-levels-the-portuguese-sibling-study-on-growth-fitness-lifestyle-and-health
#20
S Pereira, P T Katzmarzyk, T N Gomes, M Souza, R N Chaves, F K Santos, D Santos, A Bustamante, T V Barreira, D Hedeker, J A Maia
OBJECTIVES: To investigate the relationships of biological, behavioral, familial, and environmental characteristics with siblings´ physical activity (PA) levels as well as the intrapair resemblance in PA. METHODS: The sample comprises 834 (390 females) biological siblings [brother-brother (BB), sister-sister (SS), brother-sister (BS)] aged 9 to 20 years. Total PA index (TPAI) was estimated by questionnaire. Information on potential behavioral, familial, and environmental correlates was obtained by self-report; body mass index (BMI), biological maturation, and physical fitness were measured...
September 19, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
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