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https://www.readbyqxmd.com/read/28416195/pitavastatin-versus-pravastatin-in-adults-with-hiv-1-infection-and-dyslipidaemia-intrepid-12-week-and-52-week-results-of-a-phase-4-multicentre-randomised-double-blind-superiority-trial
#1
Judith A Aberg, Craig A Sponseller, Douglas J Ward, Vladimir A Kryzhanovski, Stuart E Campbell, Melanie A Thompson
BACKGROUND: People living with HIV-1 infection are at greater risk for cardiovascular disease than seronegative adults. Treatment of dyslipidaemia with statins has been challenging in people with HIV because of an increased potential for drug interactions due to competing cytochrome P450 metabolism between statins and commonly used antiretroviral agents. Neither pitavastatin nor pravastatin depend on cytochrome P450 for primary metabolism. We aimed to assess the safety and efficacy of pitavastatin versus pravastatin in adults with HIV and dyslipidaemia...
April 13, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28400027/socioeconomic-status-as-a-predictor-of-mortality-in-patients-admitted-with-atrial-fibrillation
#2
Faraj Kargoli, Eric Shulman, Philip Aagaard, David F Briceno, Ethan Hoch, Luigi Di Biase, John D Fisher, Jay Gross, Soo G Kim, Andrew Krumerman, Kevin J Ferrick
Lower socioeconomic status (SES) is associated with a higher risk of cardiovascular disease. However, the association between SES and mortality in patients with atrial fibrillation (AF) is not clear. We examined whether SES predicts all-cause mortality in patients hospitalized with AF. This is a retrospective study of patients aged >18 years, admitted with a primary diagnosis of AF to Montefiore Medical Center between 2000 and 2010. Multivariable logistic regression models were used to determine predictors of survival adjusted for age, gender, heart failure, diabetes mellitus, chronic kidney disease, previous myocardial infraction, chronic obstructive pulmonary disease, hypertension, peripheral vascular disease, and SES...
March 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28387815/atherosclerotic-plaque-vulnerability-in-the-statin-era
#3
Jan Nilsson
Life style changes and improved medical therapy have decreased cardiovascular mortality in many countries over the last decades. This has been accompanied by changes in disease characteristics including more non-ST segment elevation myocardial infraction and less vulnerable plaques as assessed by histological analysis of surgical specimens. However, many patients with established disease still suffer from recurrent cardiovascular events in spite of treatment with state-of-the-art-therapy including statins. It is likely that this reflects a state of the disease in which statins control the pro-inflammatory effects of lipids allowing other statin-unresponsive disease mechanisms to become increasingly important...
April 6, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28374574/a-comparative-assessment-of-adipose-derived-stem-cells-from-subcutaneous-and-visceral-fat-as-a-potential-cell-source-for-knee-osteoarthritis-treatment
#4
Yan Tang, Zhang-Yi Pan, Ying Zou, Yi He, Peng-Yuan Yang, Qi-Qun Tang, Feng Yin
The intra-articular injection of adipose-derived stem cells (ASCs) is a novel potential therapy for patients with osteoarthritis (OA). However, the efficacy of ASCs from different regions of the body remains unknown. This study investigated whether ASCs from subcutaneous or visceral adipose tissue provide the same improvement of OA. Mouse and human subcutaneous and visceral adipose tissue were excised for ASC isolation. Morphology, proliferation, surface markers and adipocyte differentiation of subcutaneous ASCs (S-ASCs) and visceral ASCs (V-ASCs) were analysed...
April 4, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28363791/inhibition-of-long-noncoding-rna-bdnf-as-rescues-cell-death-and-apoptosis-in-hypoxia-reoxygenation-damaged-murine-cardiomyocyte
#5
Rong Zhao, Xin Wang, Tianhong Yu, Qunli Wang, Xiaoyu Yang, Jianhui Sun
BACKGROUND: Hypoxia/reoxygenation (H/R)-induced cardiomyocyte damage in vitro bears many similarities to myocardial infraction in vivo. In this study, we investigated whether long noncoding RNA (lncRNA) BDNF-AS has functional role in rescuing H/R-induced damage in cardiomyocyte in vitro. METHOD: Murine neonatal cardiomyocytes were cultured in vitro, and treated with either long (Hypoxia (L)) or short (Hypoxia (S)) H/R conditions. Viability and TUNEL assays were conducted to assess cardiomyocyte death or apoptosis...
March 28, 2017: Biochimie
https://www.readbyqxmd.com/read/28320101/effect-of-melilotus-officinalis-extract-on-the-apoptosis-of-brain-tissues-by-altering-cerebral-thrombosis-and-inflammatory-mediators-in-acute-cerebral-ischemia
#6
Gui-Cun Zhao, Yan-Ling Yuan, Feng-Rong Chai, Fa-Jing Ji
Present investigation evaluates the protective effect of Melilotus officinalis (MO) extract on the brain tissues in acute cerebral ischemia. Acute cerebral ischemia was induced by occlusion of carotid artery and rats with cerebral ischemia were treated with MO (100, 250 & 500mg/kg) for the duration of three days. Cerebral ischemia was confirmed by estimating infract volume and neurological deficit score. Moreover biochemical parameters in plasma such as 6-keto-PGF1α and TXB2 and concentration of cytokine, oxidative stress, apoptosis ratio and protein expressions of Bcl2 & Bax were estimated in the brain tissues...
March 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28299967/reducing-the-use-and-impact-of-solitary-confinement-in-corrections
#7
Cyrus Ahalt, Craig Haney, Sarah Rios, Matthew P Fox, David Farabee, Brie Williams
Purpose Although the reform of solitary confinement is underway in many jurisdictions around world, isolation remains in widespread use in many jails and prisons. The purpose of this paper is to discuss opportunities for reform in the USA that could also be applied globally. Design/methodology/approach A review of the evidence on solitary confinement policies and practices in the USA to develop recommendations for reform with global application. Findings Focusing on this evidence, the authors argue that solitary confinement is overused and recommend a multi-level approach available to correctional systems worldwide including: immediately limiting solitary confinement to only those cases in which a violent behavioral infraction has been committed for which safety cannot otherwise be achieved, ensuring the briefest terms of isolation needed to achieve legitimate and immediate correctional goals, prohibiting its use entirely for some populations, regularly reviewing all isolated prisoners for as-soon-as-possible return to general population, including the immediate return of those showing mental and physical health risk factors, assisting individuals who are transitioning out of isolation (either to the general population or to the community), and partnering with medical, public health, and criminal justice experts to develop evidence-based alternatives to solitary confinement for nearly all prisoners...
March 13, 2017: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/28295592/knockdown-of-long-non-coding-rna-zfas1-protects-cardiomyocytes-against-acute-myocardial-infarction-via-anti-apoptosis-by-regulating-mir-150-crp
#8
Tao Wu, Dan Wu, Qinghua Wu, Bing Zou, Xiao Huang, Xiaoshu Cheng, Yanqing Wu, Kui Hong, Ping Li, Renqiang Yang, Yunde Li, Yingzhang Cheng
BACKGROUND: ZFAS1 is one of cardiac-specific or cardiac-related lncRNAs. This study was to explore the functional involvement of ZFAS1 and its regulatory role in AMI. METHODS: In this study, the models of AMI rat and myocardial cell cultured under hypoxia were made. The expression of ZFAS1 and miR-150 of myocardial infarction tissue or cardiac myocytes was determined by quantitative real time PCR. The regulatory role of ZFAS1 on miR-150 was examined by RNA pull down assay...
March 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28284496/qrs-duration-and-dispersion-for-predicting-ventricular-arrhythmias-in-early-stage-of-acute-myocardial-infraction
#9
E Chávez-González, A E Rodríguez Jiménez, F L Moreno-Martínez
OBJECTIVE: To determine the relationship between QRS duration and dispersion and the occurrence of ventricular arrhythmias in early stages of acute myocardial infarction (AMI). DESIGN: A retrospective, longitudinal descriptive study was carried out. SETTING: Hospital General Universitario "Camilo Cienfuegos", Sancti Spíritus, Cuba. Secondary health care. PATIENTS OR PARTICIPANTS: A total of 209 patients diagnosed with ST-segment elevation AMI from January 2012 to June 2014...
March 8, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28254571/structural-elucidation-of-a-polysaccharide-from-lonicera-japonica-flowers-and-its-neuroprotective-effect-on-cerebral-ischemia-reperfusion-injury-in-rat
#10
Danying Su, Shi Li, Wei Zhang, Jing Wang, Jingjing Wang, Manhua Lv
A water-soluble polysaccharide, LJPB2, was purified from Lonicera japonica flowers. The present study was aimed to illustrate its structural features and its neuroprotective effect via anti-oxidant activity on focal ischemia/reperfusion (I/R) injury in rat brain. Via chemical and spectral methods, LJPB2, a polysaccharide with molecular weight of 8.9×10(3)Da, was composed of arabinose, mannose, glucose, and galactose, in a molar ratio of 1.8: 1.0: 3.6: 3.7. In addition, the linkage analysis revealed that it mainly contained 1, 4, 6-linked mannose, 1, 4-linked glucose and 1, 4-linked galactose, with a highly branched structure of araban and terminal glucose...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28252371/restaurant-inspection-frequency-the-restofreq-study
#11
Olanrewaju Medu, Hollie Turner, Jennifer A Cushon, Deborah Melis, Leslie Rea, Treena Abdellatif, Cory O Neudorf, Michael Schwandt
OBJECTIVES: Foodborne illness is an important contributor to morbidity and health system costs in Canada. Using number of critical hazards as a proxy for food safety, we sought to better understand how to improve food safety in restaurants. We compared the current standard of annual inspections to twice-yearly inspections among restaurants "at risk" for food safety infractions. These were restaurants that had three or more elevated-risk inspection ratings in the preceding 36 months. METHODS: We conducted a two-arm randomized controlled trial between November 2012 and October 2014...
March 1, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28249798/mesenchymal-stem-cells-derived-extracellular-vesicles-via-mir-210-improve-infarcted-cardiac-function-by-promotion-of-angiogenesis
#12
Na Wang, Caiyu Chen, Dezhong Yang, Qiao Liao, Hao Luo, Xinquan Wang, Faying Zhou, Xiaoli Yang, Jian Yang, Chunyu Zeng, Wei Eric Wang
Mesenchymal stem cells (MSCs) exert therapeutic effect on treating acute myocardial infarction. Recent evidence showed that paracrine function rather than direct differentiation predominately contributes to the beneficial effects of MSCs, but how the paracrine factors function are not fully elucidated. In the present study, we tested if extracellular vesicles (EVs) secreted by MSC promotes angiogenesis in infracted heart via microRNAs. Immunostaining of CD31 and matrigel plug assay were performed to detect angiogenesis in a mouse myocardial infarction (MI) model...
February 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28212603/effects-of-renal-denervation-on-cardiac-oxidative-stress-and-local-activity-of-the-sympathetic-nervous-system-and-renin-angiotensin-system-in-acute-myocardial-infracted-dogs
#13
Qiaoli Feng, Chengzhi Lu, Li Wang, Lijun Song, Chao Li, Ravi Chandra Uppada
BACKGROUND: This study sought to evaluate the therapeutic effects of renal denervation (RDN) on acute myocardial infarction (MI) in canines and explore its possible mechanisms of action. METHODS: Eighteen healthy mongrel dogs were randomly assigned to either the control group, the MI group or the MI + RDN group. To assess cardiac function, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD) and fraction shortening (FS) were recorded...
February 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28207172/drivers-of-redistribution-of-fishing-and-non-fishing-effort-after-the-implementation-of-a-marine-protected-area-network
#14
Reniel B Cabral, Steven D Gaines, Brett A Johnson, Tom W Bell, Crow White
Marine spatial planning (MSP) is increasingly utilized to sustainably manage ocean uses. Marine protected areas (MPAs), a form of spatial management in which parts of the ocean are regulated to fishing, are now a common tool in MSP for conserving marine biodiversity and managing fisheries. However, the use of MPAs in MSP often neglects, or simplifies, the redistribution of fishing and non-fishing activities inside and outside of MPAs following their implementation. This redistribution of effort can have important implications for effective MSP...
October 3, 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28185309/initial-evaluation-of-99m-tc-tricarbonyl-cyclopentadienyl-fatty-acids-derivatives-as-spect-tracers-for-myocardium
#15
Jianping Liu, Huan Wang, Shuxia Wang, Qianqian Xue, Dawei Wang, Wang Hang, Huabei Zhang
Fatty acids are myocardial metabolic agent for detecting myocardial ischemia and infraction. However, no (99m) Tc-labeled fatty acids had potential use in clinical practice. In this study, (99m) Tc-CpTT-10-oxo-para-PPA (1d), (99m) Tc-CpTT-11-oxo-para-PPA (2d), (99m) Tc-CpTT-12-oxo-para-PPA (3d), (99m) Tc-CpTT-11-oxo-ortho-PPA (4d) and (99m) Tc-CpTT-11-oxo-meta-PPA (5d) were synthesized by a double ligand transfer reaction, their biological behaviors were investigated. Compound 2d achieved good heart/blood ratio (3...
February 9, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28178170/use-of-susceptibility-weighted-imaging-in-assessing-ischemic-penumbra-a-case-report
#16
Xiujuan Wu, Song Luo, Ying Wang, Yang Chen, Jun Liu, Jing Bai, Jiachun Feng, Hongliang Zhang
RATIONALE: The ischemic penumbra assessment is essential for the subsequent therapy and prediction of evolution in patients with acute ischemic infraction. Although controversial as a perfect equivalence to penumbra, perfusion-weighted imaging (PWI)-diffusion-weighted imaging (DWI) mismatch may predict the response to thrombolysis. Due to the reliance of PWI on contrast agents, noninvasive alternatives remain an unmet need. PATIENT CONCERNS: We reported a 65-year-old man complained of paroxysmal hemiplegia of his right limbs and anepia for 2 days, whereas the symptoms lasted for about 12 hours when he admitted to the hospital...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28176299/loss-of-institutional-trust-among-racial-and-ethnic-minority-adolescents-a-consequence-of-procedural-injustice-and-a-cause-of-life-span-outcomes
#17
David S Yeager, Valerie Purdie-Vaughns, Sophia Yang Hooper, Geoffrey L Cohen
This research tested a social-developmental process model of trust discernment. From sixth to eighth grade, White and African American students were surveyed twice yearly (ages 11-14; Study 1, N = 277). African American students were more aware of racial bias in school disciplinary decisions, and as this awareness grew it predicted a loss of trust in school, leading to a large trust gap in seventh grade. Loss of trust by spring of seventh grade predicted African Americans' subsequent discipline infractions and 4-year college enrollment...
February 8, 2017: Child Development
https://www.readbyqxmd.com/read/28164397/four-main-active-ingredients-derived-from-a-traditional-chinese-medicine-guanxin-shutong-capsule-cause-cardioprotection-during-myocardial-ischemia-injury-calcium-overload-suppression
#18
Feng Liu, Zhuang-Zhuang Huang, Yu-Hong Sun, Ting Li, Dong-Hua Yang, Gang Xu, Ying-Ying Su, Tao Zhang
Guanxin Shutong capsule is a traditional Chinese medicine for the treatment of myocardial ischemia (MI). Previous studies have shown that the formula has four main active ingredients (FMAI), protocatechuic acid, cryptotanshinone, borneol, and eugenol. However, the mechanisms of action of these FMAI against MI injury are still not well known. The aim of the present study was to evaluate the protective effects of the FMAI on MI in vitro and in vivo. In vitro, rat neonatal cardiomyocytes were isolated, the cell viability and apoptosis rate were, respectively, measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and fluorescence activating cell sorter, and the intracellular calcium concentration ([Ca(2+) ]i ) and CaM and CaMKII δ mRNA as well as protein levels were determined...
February 6, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28157741/avoiding-infractions-in-the-management-of-infarctions
#19
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28133020/-examination-of-patients-with-malignant-obstruction-treated-with-chemotherapy-after-ileo-coleostomy
#20
Hidemi Nishi, Ken Nakata, Yoko Hiraki, Junpei Yoshimura, Shingo Sasamatsu, Katsushu Shimizu, Toshiya Inoue, Jota Mikami, Genta Sawada, Shin Nakahira, Yoichi Makari, Tameyoshi Yamamoto, Masaki Tsujie, Yutaka Kimura, Hiroki Ohsato
Management for obstructive cancer of the colon diverges into many ways. The aim of this study was to evaluate the treatment course of patients with malignant obstruction after ileo/coleostomy. Thirty-six patients with malignant obstruction who underwent ileo/coleostomy in our hospital from May 2012 to January 2016were enrolled in the study. Clinical outcomes were the period before treatment initiation, chemotherapy, radiotherapy, primary lesion resection, and death, and these were retrospectively analyzed. Although 9 stomal complications occurred, no case experienced a delayed treatment start...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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