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https://www.readbyqxmd.com/read/29751831/intravenous-injection-of-allogeneic-umbilical-cord-derived-multipotent-mesenchymal-stromal-cells-reduces-the-infarct-area-and-ameliorates-cardiac-function-in-a-porcine-model-of-acute-myocardial-infarction
#1
Meikuang Lim, Weiqiang Wang, Lu Liang, Zhi-Bo Han, Zongjin Li, Jie Geng, Meng Zhao, Honghong Jia, Jie Feng, Zhe Wei, Baoquan Song, Jiemin Zhang, Jun Li, Tianwen Liu, Fan Wang, Ting Li, Jianming Li, Yihu Fang, Jianhua Gao, Zhongchao Han
BACKGROUND: Multipotent mesenchymal stromal cell (MSC) therapy has been widely recognized as a feasible strategy for regenerating injured myocardial tissue. However, little is known about the efficacy of intravenous injection of allogeneic umbilical cord (UC) MSCs in preclinical models of porcine myocardial infarction. METHODS: Different dosages of allogeneic UC-MSCs or the vehicle [phosphate-buffered saline (PBS)] were delivered intravenously into an acute myocardial infarction (AMI) porcine model twice after coronary ligation...
May 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29730590/the-use-of-administrative-sanctions-to-prevent-environmental-damage-in-impact-assessment-follow-ups
#2
Luiz Carlos Garcia, Alberto Fonseca
Scholars have long been highlighting the value of administrative sanctions in improving environmental policy enforcement. However, few studies have evaluated how such sanctions are implemented, particularly in the context of environmental impact assessments (EIA) and their respective follow-up programs. The main objective of this article was to evaluate how administrative sanctions have been used in EIA follow-ups, using the Brazilian state of Minas Gerais as the empirical context. More specifically it tried to understand what have been the main triggers, frequency, nature and financial values of the sanctions issued to noncompliant mining projects operating under the conditions of environmental licenses...
May 3, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29713657/the-impact-of-university-sanctions-on-cannabis-use-individual-difference-factors-that-predict-change-in-cannabis-use
#3
Julia D Buckner, Katherine A Walukevich, Austin W Lemke, Emily R Jeffries
Over one-third of college students use cannabis, yet the majority of students experiencing cannabis-use problems are not interested in seeking treatment. Therefore, the campus judicial process following a violation of university cannabis policies may be an important point of intervention. This study examined whether cannabis use decreased following being sanctioned by the university for violation of campus drug policy. We also identified individual difference factors related to changes in post-infraction use...
March 2018: Translational Issues in Psychological Science
https://www.readbyqxmd.com/read/29706116/approved-and-off-label-use-of-prescribed-psychotropic-medications-among-federal-canadian-inmates
#4
Gregory P Brown, Lynn A Stewart, Terry Rabinowitz, Harold Boudreau, Angela J Wright
OBJECTIVE: To examine psychotropic medication prescription practices in federal Canadian penitentiaries. METHOD: 468 files were drawn from a purposive sample of thirteen Canadian federal institutions representing the five regions, different security levels, and male and female designated facilities. Information on the names of all psychotropic medications prescribed, indications for use, dosage, frequency, and route of administration was retrieved. Designation of approved or off-label use of medications was determined by consulting: (1) the Health Canada (2016) Drug Product Database, (2) the Canadian Compendium of Pharmaceuticals and Specialties 2016, and (3) the American Hospital Formulary Service Drug Information 2016...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29685057/sexual-violence-among-male-inmates
#5
Carly M Hilinski-Rosick, Tina L Freiburger
Inmate misconduct has been a widely studied topic for many decades. General studies of misconduct have found that there are certain factors that contribute to misconduct, including age, gender, sentence length, and facility type. Few studies, however, have examined the factors predicting sexual offenses in a prison conduct. Although many studies of victims of sexual offenses in prison have been conducted, there is a lack of studies examining the perpetrators of prison sexual violence. The current study attempted to expand this body of literature by examining the correlates of sexual misconduct among a sample of male inmates incarcerated in the state of North Carolina during 2010...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29677548/combination-of-curcumin-and-vagus-nerve-stimulation-attenuates-cerebral-ischemia-reperfusion-injury-induced-behavioral-deficits
#6
Jian Xu, Xinjuan Kong, Hong Xiu, Yihe Dou, Zeyu Wu, Peng Sun
AIM: Previous studies indicated that cerebral ischemia/reperfusion injury (CI/RI) could induce behavioral deficits. Single treatment of vagus nerve stimulation (VNS) or curcumin is reported to restore CI/RI-induced behavioral deficits. However, the synergic effect remains unclear. MATERIALS AND METHODS: Rats were divided into 6 groups: sham, CI/RI, VNS, CI/RI + VNS, VNS + curcumin and CI/RI + VNS + curcumin groups. Each group was further divided into three or four subgroups for further assessments...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29665017/prognostic-value-of-exercise-capacity-among-patients-with-treated-depression-the-henry-ford-exercise-testing-fit-project
#7
Amjad M Ahmed, Waqas T Qureshi, Sherif Sakr, Michael J Blaha, Clinton A Brawner, Jonathan K Ehrman, Steven J Keteyian, Mouaz H Al-Mallah
BACKGROUND: Exercise capacity is associated with survival in the general population. Whether this applies to patients with treated depression is not clear. HYPOTHESIS: High exercise capacity remains associated with lower risk of all-cause mortality (ACM) and nonfatal myocardial infraction (MI) among patients with treated depression. METHODS: We included 5128 patients on antidepressant medications who completed a clinically indicated exercise stress test between 1991 and 2009...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29660674/the-relation-of-borderline-personality-disorder-to-aggression-victimization-and-institutional-misconduct-among-prisoners
#8
Kelly E Moore, Robyn L Gobin, Heather L McCauley, Chien-Wen Kao, Stephanie M Anthony, Sheryl Kubiak, Caron Zlotnick, Jennifer E Johnson
OBJECTIVE: Borderline personality disorder (BPD) is highly prevalent among incarcerated populations; however, research has yet to examine whether prisoners diagnosed with BPD experience greater interpersonal dysfunction and institutional misconduct while incarcerated. PROCEDURE: This study drew from a sample of 184 male and female prisoners diagnosed with major depressive disorder (MDD) in a randomized trial of depression treatment. The presence of a BPD diagnosis (n = 69) was analyzed as a predictor of disciplinary incidents/infractions (i...
March 21, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29627893/fabrication-of-an-immunosensor-for-early-and-ultrasensitive-determination-of-human-tissue-plasminogen-activator-tpa-in-myocardial-infraction-and-breast-cancer-patients
#9
Haidar Saify Nabiabad, Khosro Piri, Fatemeh Kafrashi, Abbas Afkhami, Tayyebeh Madrakian
Sensitive detection of biomarkers will mean accurate and early diagnosis of diseases. A tissue plasminogen activator (tPA) has a crucial role in many cardiovascular diseases and it is related to many processes such as angiogenesis in cancer cells. Therefore, sensitive determination of tPA is important in diagnosis and clinical research. tPA monoclonal antibody was covalently attached onto single-wall carbon nanotubes (SWCNTs) using diimide-activated imidation coupling. Functionalized SWCNTs were immobilized onto a glassy carbon electrode and the modification process was investigated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), SEM, cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS)...
April 7, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29611444/combination-oral-antithrombotic-therapy-for-the-treatment-of-myocardial-infarction-recent-developments
#10
Udaya S Tantry, Eliano P Navarese, Aung Myat, Rahul Chaudhary, Paul A Gurbel
There have been significant new developments in the treatment of patients with myocardial infarction with respect to oral antithrombotic agents over the past decade. Recent studies have explored the potential utility of targeting the dual pathway inhibition of platelet function with single or dual antiplatelet agents and the thrombin pathway with direct thrombin inhibitors or factor Xa inhibitors. Areas covered: In this review, the authors focus on the recent developments of oral antithrombotic agents including antiplatelet and antithrombin agents...
April 3, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29606286/referral-regions-for-time-sensitive-acute-care-conditions-in-the-united-states
#11
David J Wallace, Deepika Mohan, Derek C Angus, Julia R Driessen, Christopher M Seymour, Donald M Yealy, Mark M Roberts, Kristen S Kurland, Jeremy M Kahn
STUDY OBJECTIVE: Regional, coordinated care for time-sensitive and high-risk medical conditions is a priority in the United States. A necessary precursor to coordinated regional care is regions that are actionable from clinical and policy standpoints. The Dartmouth Atlas of Health Care, the major health care referral construct in the United States, uses regions that cross state and county boundaries, limiting fiscal or political ownership by key governmental stakeholders in positions to create incentive and regulate regional care coordination...
March 24, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29568858/cardioprotective-effect-of-rosuvastatin-against-isoproterenol-induced-myocardial-infarction-injury-in-rats
#12
Ying Yu, Lin Jin, Yamin Zhuang, Yan Hu, Jing Cang, Kefang Guo
Rosuvastatin, a member of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, exerts various pharmacological activities. This study evaluated the cardioprotective effect of rosuvastatin on isoproterenol-induced myocardial infarction injury in rats. A rat model of myocardial infarction injury was induced by isoproterenol (ISO) for 2 consecutive days, rosuvastatin was administered for 8 weeks. The levels of myocardial infarct size, aspartate transaminase (AST), alanine transaminase (ALT), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) activities, as well as malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) activities and reduced glutathione (GSH) concentrations were determined...
March 15, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29565510/analysis-of-related-factors-of-orolingual-angioedema-after-rt-pa-intravenous-thrombolytic-therapy
#13
Y-X Wang, Y-Q Li, Y Chen, C-H Zhang, Z Dong, Z Wang, S-N Zhao, C-H Li, P-L Zhang
OBJECTIVE: Orolingual angioedema (OA) is a rare clinical complication with a potentially fatal risk that occurs after the intravenous application of alteplase (rt-PA) in patients with acute ischemic stroke. The purpose of this work is to investigate the related factors of OA in patients with acute ischemic stroke after the administration of intravenous thrombolytic therapy, to improve the predictive ability of OA during intravenous thrombolytic therapy, and to reduce the prevalence of complications...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29559953/secretoneurin-a-directly-regulates-the-proteome-of-goldfish-radial-glial-cells-in-vitro
#14
Dillon F Da Fonte, Chris J Martyniuk, Lei Xing, Vance L Trudeau
Radial glial cells (RGCs) are the main macroglia in the teleost brain and have established roles in neurogenesis and neurosteroidogenesis. They are the only brain cell type expressing aromatase B ( cyp19a1b ), the enzyme that synthesizes estrogens from androgen precursors. There are few studies on the regulation of RGC functions, but our previous investigations demonstrated that dopamine stimulates cyp19a1b expression in goldfish RGCs, while secretoneurin A (SNa) inhibits the expression of this enzyme. Here, we determine the range of proteins and cellular processes responsive to SNa treatments in these steroidogenic cells...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29525809/proliferation-of-bilateral-nerve-fibers-following-thalamic-infarction-contributes-to-neurological-function-recovery-a-diffusion-tensor-imaging-dti-study
#15
Yayuan Liu, Li Chen, Jinseng Zeng, Wenmei Li, Sudan Zeng, Bin Ye, Zhijian Liang
BACKGROUND The aim of this study was to investigate the reorganization in ipsilesional and contralesional thalamic radiation fibers after unilateral focal thalamic stroke in sensory disturbance patients. MATERIAL AND METHODS We recruited 12 patients with acute unilateral thalamic infarction and sensory disturbance and 12 healthy age- and sex-matched controls. All patients underwent diffusion tensor imaging (DTI) and were assessed with National Institutes of Health stroke scale (NIHSS), Barthel index (BI), and paragraph 8 of NIHSS (NIHSS8) at 1 week (W1), 4 weeks (W4), 3 months (M3), and 6 months (M6) after thalamic infraction...
March 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29524303/tanshinone-iia-prevents-left-ventricular-remodelling-via-the-tlr4-myd88-nf-%C3%AE%C2%BAb-signalling-pathway-in-rats-with-myocardial-infarction
#16
Dong-Mei Wu, Yong-Jian Wang, Xin-Rui Han, Xin Wen, Lei Li, Lan Xu, Jun Lu, Yuan-Lin Zheng
In this study, we aim to investigate the role of tanshinone IIA in myocardial infarction (MI), especially in left ventricular remodelling (VR) and the underlying mechanism involving the TLR4/MyD88/NF-κB signalling pathway. Sprague-Dawley (SD) rats (n = 96) were selected, and 12 of them underwent sham surgery. The remaining 84 rats were subjected to MI modelling. HE and MT staining were carried out to estimate infract size, histopathological changes and fibrosis degree. Macrophage infiltration and cardiomyocyte apoptosis were evaluated by immunohistochemistry and TUNEL staining...
March 10, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29496587/traumatic-brain-injury-a-potential-cause-of-violent-crime
#17
REVIEW
W Huw Williams, Prathiba Chitsabesan, Seena Fazel, Tom McMillan, Nathan Hughes, Michael Parsonage, James Tonks
Traumatic brain injury (TBI) is the biggest cause of death and disability in children and young people. TBI compromises important neurological functions for self-regulation and social behaviour and increases risk of behavioural disorder and psychiatric morbidity. Crime in young people is a major social issue. So-called early starters often continue for a lifetime. A substantial majority of young offenders are reconvicted soon after release. Multiple factors play a role in crime. We show how TBI is a risk factor for earlier, more violent, offending...
February 26, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29491626/cerebroprotective-actions-of-triticum-aestivum-linn-powder-and-bauhinia-purpurea-flower-powder-in-surgically-induced-cerebral-infraction-in-rats
#18
Akula Annapurna, Thonangi C Vishala, Veera R Bitra, Deepthi Rapaka, Asmath Shaik
Objective: The prime objective of this study is to evaluate the cerebroprotective actions of Triticum aestivum (wheatgrass) powder and Bauhinia purpurea flower (dev kanchan) powder against the experimentally induced global ischemia reperfusion injury in rats. Materials and Methods: In the first phase of the studies, 1 h before the surgical procedure, the Wistar rats were orally served with varied doses of wheatgrass powder (5, 10, 30, and 100 μg/kg) and Bauhinia flower powder (30, 100, 200, and 300 μg/kg), respectively...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29489821/design-monitoring-and-evaluation-of-a-direct-payments-approach-for-an-ecotourism-strategy-to-reduce-illegal-hunting-and-trade-of-wildlife-in-lao-pdr
#19
Paul Frederick Eshoo, Arlyne Johnson, Sivilay Duangdala, Troy Hansel
Ecotourism as a strategy for achieving biodiversity conservation often results in limited conservation impact relative to its investment and revenue return. In cases where an ecotourism strategy has been used, projects are frequently criticized for not providing sufficient evidence on how the strategy has reduced threats or improved the status of the biodiversity it purports to protect. In Lao PDR, revenue from ecotourism has not been directly linked to or dependent on improvements in biodiversity and there is no evidence that ecotourism enterprises have contributed to conservation...
2018: PloS One
https://www.readbyqxmd.com/read/29484378/exosomes-derived-from-human-umbilical-cord-mesenchymal-stem-cells-improve-myocardial-repair-via-upregulation-of-smad7
#20
Xin-Long Wang, Yuan-Yuan Zhao, Li Sun, Yu Shi, Zhu-Qian Li, Xiang-Dong Zhao, Chang-Gen Xu, Hong-Ge Ji, Mei Wang, Wen-Rong Xu, Wei Zhu
It has been previously reported that exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC)‑exosomes exhibit cardioprotective effects on the rat acute myocardial infarction (AMI) models and cardiomyocyte hypoxia injury models in vitro, however the exact mechanisms involved require further investigation. The present study aimed to investigate the repair effects of hucMSC‑exosomes on myocardial injury via the regulation of mothers against decapentaplegic homolog 7 (Smad7) expression...
May 2018: International Journal of Molecular Medicine
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