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https://www.readbyqxmd.com/read/28320101/effect-of-melilotus-officinalis-extract-on-the-apoptosis-of-brain-tissues-by-altering-cerebral-thrombosis-and-inflammatory-mediators-in-acute-cerebral-ischemia
#1
Gui-Cun Zhao, Yan-Ling Yuan, Feng-Rong Chai, Fa-Jing Ji
Present investigation evaluates the protective effect of Melilotus officinalis (MO) extract on the brain tissues in acute cerebral ischemia. Acute cerebral ischemia was induced by occlusion of carotid artery and rats with cerebral ischemia were treated with MO (100, 250 & 500mg/kg) for the duration of three days. Cerebral ischemia was confirmed by estimating infract volume and neurological deficit score. Moreover biochemical parameters in plasma such as 6-keto-PGF1α and TXB2 and concentration of cytokine, oxidative stress, apoptosis ratio and protein expressions of Bcl2 & Bax were estimated in the brain tissues...
March 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28299967/reducing-the-use-and-impact-of-solitary-confinement-in-corrections
#2
Cyrus Ahalt, Craig Haney, Sarah Rios, Matthew P Fox, David Farabee, Brie Williams
Purpose Although the reform of solitary confinement is underway in many jurisdictions around world, isolation remains in widespread use in many jails and prisons. The purpose of this paper is to discuss opportunities for reform in the USA that could also be applied globally. Design/methodology/approach A review of the evidence on solitary confinement policies and practices in the USA to develop recommendations for reform with global application. Findings Focusing on this evidence, the authors argue that solitary confinement is overused and recommend a multi-level approach available to correctional systems worldwide including: immediately limiting solitary confinement to only those cases in which a violent behavioral infraction has been committed for which safety cannot otherwise be achieved, ensuring the briefest terms of isolation needed to achieve legitimate and immediate correctional goals, prohibiting its use entirely for some populations, regularly reviewing all isolated prisoners for as-soon-as-possible return to general population, including the immediate return of those showing mental and physical health risk factors, assisting individuals who are transitioning out of isolation (either to the general population or to the community), and partnering with medical, public health, and criminal justice experts to develop evidence-based alternatives to solitary confinement for nearly all prisoners...
March 13, 2017: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/28295592/knockdown-of-long-non-coding-rna-zfas1-protects-cardiomyocytes-against-acute-myocardial-infarction-via-anti-apoptosis-by-regulating-mir-150-crp
#3
Tao Wu, Dan Wu, Qinghua Wu, Bing Zou, Xiao Huang, Xiaoshu Cheng, Yanqing Wu, Kui Hong, Ping Li, Renqiang Yang, Yunde Li, Yingzhang Cheng
BACKGROUND: ZFAS1 is one of cardiac-specific or cardiac-related lncRNAs. This study was to explore the functional involvement of ZFAS1 and its regulatory role in AMI. METHODS: In this study, the models of AMI rat and myocardial cell cultured under hypoxia were made. The expression of ZFAS1 and miR-150 of myocardial infarction tissue or cardiac myocytes was determined by quantitative real time PCR. The regulatory role of ZFAS1 on miR-150 was examined by RNA pull down assay...
March 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28284496/qrs-duration-and-dispersion-for-predicting-ventricular-arrhythmias-in-early-stage-of-acute-myocardial-infraction
#4
E Chávez-González, A E Rodríguez Jiménez, F L Moreno-Martínez
OBJECTIVE: To determine the relationship between QRS duration and dispersion and the occurrence of ventricular arrhythmias in early stages of acute myocardial infarction (AMI). DESIGN: A retrospective, longitudinal descriptive study was carried out. SETTING: Hospital General Universitario "Camilo Cienfuegos", Sancti Spíritus, Cuba. Secondary health care. PATIENTS OR PARTICIPANTS: A total of 209 patients diagnosed with ST-segment elevation AMI from January 2012 to June 2014...
March 8, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28254571/structural-elucidation-of-a-polysaccharide-from-lonicera-japonica-flowers-and-its-neuroprotective-effect-on-cerebral-ischemia-reperfusion-injury-in-rat
#5
Danying Su, Shi Li, Wei Zhang, Jing Wang, Jingjing Wang, Manhua Lv
A water-soluble polysaccharide, LJPB2, was purified from Lonicera japonica flowers. The present study was aimed to illustrate its structural features and its neuroprotective effect via anti-oxidant activity on focal ischemia/reperfusion (I/R) injury in rat brain. Via chemical and spectral methods, LJPB2, a polysaccharide with molecular weight of 8.9×10(3)Da, was composed of arabinose, mannose, glucose, and galactose, in a molar ratio of 1.8: 1.0: 3.6: 3.7. In addition, the linkage analysis revealed that it mainly contained 1, 4, 6-linked mannose, 1, 4-linked glucose and 1, 4-linked galactose, with a highly branched structure of araban and terminal glucose...
February 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28252371/restaurant-inspection-frequency-the-restofreq-study
#6
Olanrewaju Medu, Hollie Turner, Jennifer A Cushon, Deborah Melis, Leslie Rea, Treena Abdellatif, Cory O Neudorf, Michael Schwandt
OBJECTIVES: Foodborne illness is an important contributor to morbidity and health system costs in Canada. Using number of critical hazards as a proxy for food safety, we sought to better understand how to improve food safety in restaurants. We compared the current standard of annual inspections to twice-yearly inspections among restaurants "at risk" for food safety infractions. These were restaurants that had three or more elevated-risk inspection ratings in the preceding 36 months. METHODS: We conducted a two-arm randomized controlled trial between November 2012 and October 2014...
March 1, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28249798/mesenchymal-stem-cells-derived-extracellular-vesicles-via-mir-210-improve-infarcted-cardiac-function-by-promotion-of-angiogenesis
#7
Na Wang, Caiyu Chen, Dezhong Yang, Qiao Liao, Hao Luo, Xinquan Wang, Faying Zhou, Xiaoli Yang, Jian Yang, Chunyu Zeng, Wei Eric Wang
Mesenchymal stem cells (MSCs) exert therapeutic effect on treating acute myocardial infarction. Recent evidence showed that paracrine function rather than direct differentiation predominately contributes to the beneficial effects of MSCs, but how the paracrine factors function are not fully elucidated. In the present study, we tested if extracellular vesicles (EVs) secreted by MSC promotes angiogenesis in infracted heart via microRNAs. Immunostaining of CD31 and matrigel plug assay were performed to detect angiogenesis in a mouse myocardial infarction (MI) model...
February 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28212603/effects-of-renal-denervation-on-cardiac-oxidative-stress-and-local-activity-of-the-sympathetic-nervous-system-and-renin-angiotensin-system-in-acute-myocardial-infracted-dogs
#8
Qiaoli Feng, Chengzhi Lu, Li Wang, Lijun Song, Chao Li, Ravi Chandra Uppada
BACKGROUND: This study sought to evaluate the therapeutic effects of renal denervation (RDN) on acute myocardial infarction (MI) in canines and explore its possible mechanisms of action. METHODS: Eighteen healthy mongrel dogs were randomly assigned to either the control group, the MI group or the MI + RDN group. To assess cardiac function, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD) and fraction shortening (FS) were recorded...
February 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28207172/drivers-of-redistribution-of-fishing-and-non-fishing-effort-after-the-implementation-of-a-marine-protected-area-network
#9
Reniel B Cabral, Steven D Gaines, Brett A Johnson, Tom W Bell, Crow White
Marine spatial planning (MSP) is increasingly utilized to sustainably manage ocean uses. Marine protected areas (MPAs), a form of spatial management in which parts of the ocean are regulated to fishing, are now a common tool in MSP for conserving marine biodiversity and managing fisheries. However, the use of MPAs in MSP often neglects, or simplifies, the redistribution of fishing and non-fishing activities inside and outside of MPAs following their implementation. This redistribution of effort can have important implications for effective MSP...
October 3, 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28185309/initial-evaluation-of-99m-tc-tricarbonyl-cyclopentadienyl-fatty-acids-derivatives-as-spect-tracers-for-myocardium
#10
Jianping Liu, Huan Wang, Shuxia Wang, Qianqian Xue, Dawei Wang, Wang Hang, Huabei Zhang
Fatty acids are myocardial metabolic agent for detecting myocardial ischemia and infraction. However, no (99m) Tc-labeled fatty acids had potential use in clinical practice. In this study, (99m) Tc-CpTT-10-oxo-para-PPA (1d), (99m) Tc-CpTT-11-oxo-para-PPA (2d), (99m) Tc-CpTT-12-oxo-para-PPA (3d), (99m) Tc-CpTT-11-oxo-ortho-PPA (4d) and (99m) Tc-CpTT-11-oxo-meta-PPA (5d) were synthesized by a double ligand transfer reaction, their biological behaviors were investigated. Compound 2d achieved good heart/blood ratio (3...
February 9, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28178170/use-of-susceptibility-weighted-imaging-in-assessing-ischemic-penumbra-a-case-report
#11
Xiujuan Wu, Song Luo, Ying Wang, Yang Chen, Jun Liu, Jing Bai, Jiachun Feng, Hongliang Zhang
RATIONALE: The ischemic penumbra assessment is essential for the subsequent therapy and prediction of evolution in patients with acute ischemic infraction. Although controversial as a perfect equivalence to penumbra, perfusion-weighted imaging (PWI)-diffusion-weighted imaging (DWI) mismatch may predict the response to thrombolysis. Due to the reliance of PWI on contrast agents, noninvasive alternatives remain an unmet need. PATIENT CONCERNS: We reported a 65-year-old man complained of paroxysmal hemiplegia of his right limbs and anepia for 2 days, whereas the symptoms lasted for about 12 hours when he admitted to the hospital...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28176299/loss-of-institutional-trust-among-racial-and-ethnic-minority-adolescents-a-consequence-of-procedural-injustice-and-a-cause-of-life-span-outcomes
#12
David S Yeager, Valerie Purdie-Vaughns, Sophia Yang Hooper, Geoffrey L Cohen
This research tested a social-developmental process model of trust discernment. From sixth to eighth grade, White and African American students were surveyed twice yearly (ages 11-14; Study 1, N = 277). African American students were more aware of racial bias in school disciplinary decisions, and as this awareness grew it predicted a loss of trust in school, leading to a large trust gap in seventh grade. Loss of trust by spring of seventh grade predicted African Americans' subsequent discipline infractions and 4-year college enrollment...
February 8, 2017: Child Development
https://www.readbyqxmd.com/read/28164397/four-main-active-ingredients-derived-from-a-traditional-chinese-medicine-guanxin-shutong-capsule-cause-cardioprotection-during-myocardial-ischemia-injury-calcium-overload-suppression
#13
Feng Liu, Zhuang-Zhuang Huang, Yu-Hong Sun, Ting Li, Dong-Hua Yang, Gang Xu, Ying-Ying Su, Tao Zhang
Guanxin Shutong capsule is a traditional Chinese medicine for the treatment of myocardial ischemia (MI). Previous studies have shown that the formula has four main active ingredients (FMAI), protocatechuic acid, cryptotanshinone, borneol, and eugenol. However, the mechanisms of action of these FMAI against MI injury are still not well known. The aim of the present study was to evaluate the protective effects of the FMAI on MI in vitro and in vivo. In vitro, rat neonatal cardiomyocytes were isolated, the cell viability and apoptosis rate were, respectively, measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and fluorescence activating cell sorter, and the intracellular calcium concentration ([Ca(2+) ]i ) and CaM and CaMKII δ mRNA as well as protein levels were determined...
February 6, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28157741/avoiding-infractions-in-the-management-of-infarctions
#14
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28133020/-examination-of-patients-with-malignant-obstruction-treated-with-chemotherapy-after-ileo-coleostomy
#15
Hidemi Nishi, Ken Nakata, Yoko Hiraki, Junpei Yoshimura, Shingo Sasamatsu, Katsushu Shimizu, Toshiya Inoue, Jota Mikami, Genta Sawada, Shin Nakahira, Yoichi Makari, Tameyoshi Yamamoto, Masaki Tsujie, Yutaka Kimura, Hiroki Ohsato
Management for obstructive cancer of the colon diverges into many ways. The aim of this study was to evaluate the treatment course of patients with malignant obstruction after ileo/coleostomy. Thirty-six patients with malignant obstruction who underwent ileo/coleostomy in our hospital from May 2012 to January 2016were enrolled in the study. Clinical outcomes were the period before treatment initiation, chemotherapy, radiotherapy, primary lesion resection, and death, and these were retrospectively analyzed. Although 9 stomal complications occurred, no case experienced a delayed treatment start...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28129703/risk-factors-associated-with-near-lethal-suicide-attempts-during-incarceration-among-men-in-the-spanish-prison-system
#16
Francisco Caravaca Sánchez, Noelle Fearn, Michael G Vaughn
Studies conducted worldwide indicate that near-lethal suicide attempts are common among incarcerated populations. However, little research attention has been focused on the Spanish prison population. To address this gap in the literature, data were drawn from a sample of men ( N = 2,270) incarcerated in seven prisons in Spain. We compared sociodemographic, criminal/offense, health and mental health, and life events in prison variables between inmates who reported making near-lethal suicide attempts ( n = 616) and those who did not ( n = 1,654) during their current incarceration term...
January 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/28114093/-cotard-s-syndrome-case-report-and-a-brief-review-of-literature
#17
N P Moschopoulos, S Kaprinis, J Nimatoudis
The term "Cotard's syndrome" is used to describe a number of clinical features, mostly hypochondriac and nihilistic delusions, the most characteristic of which are the ideas "I am dead" and "my internal organs do not exist". Besides, anxious and depressed mood, delusions of damnation, possession and immortality, suicidal and self-mutilating behavior are included. The first description of the syndrome was made in 1880 by Cotard, who presented the case of a female patient in a lecture. He originally named it "hypochondriac delusion", and some years later "delusion of negations", while it was named "Cotard delusion" after his death...
October 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28111239/benefits-and-harms-of-atypical-antipsychotics-for-agitation-in-adults-with-dementia
#18
REVIEW
Martin R Farlow, Tatyana A Shamliyan
We evaluated the most current evidence regarding the benefits and harms of atypical antipsychotics in adults with dementia. In June 2016, following a protocol developed a priori, we systematically searched several databases for published and unpublished data from randomized controlled trials (RCT), observational studies, and meta-analyses; conducted direct meta-analyses using a random effects model; and graded the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group...
March 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28101856/relationship-of-long-term-prognosis-to-mmp-and-timp-polymorphisms-in-patients-after-st-elevation-myocardial-infarction
#19
Monika Pavkova Goldbergova, Jiri Jarkovsky, Jolana Lipkova, Simona Littnerova, Martin Poloczek, Jindrich Spinar, Lenka Kubkova, Krystyna Kluz, Petr Kala, Jan Manousek, Anna Vasku, Jiri Parenica
The influence of polymorphisms in the large group of MMP and TIMP genes on clinical outcomes in patients after ST elevation myocardial infarction (STEMI) treated with primary PCI was analysed. In total, 550 consecutive Caucasian patients with STEMI were included in the present study, with a median of 32 months. We analysed 19 polymorphisms in the genes coding MMP and TIMP genes. The MMP-1 -519A/G and -422A/T polymorphisms are associated with combined endpoint after myocardial infarction. The hazard ratio for AT variant of MMP-1 -422A/T was 1...
January 18, 2017: Journal of Applied Genetics
https://www.readbyqxmd.com/read/28100343/-effect-of-stenting-for-the-proximal-atherosclerotic-extracranial-vertebral-artery-stenosis
#20
W Q Che, X J Jiang, H Dong, M Peng, Y B Zou, L Song, H M Zhang, H L Xiong, H Y Wu
Objective: To evaluate the effect of stenting for proximal atherosclerotic extracranial vertebral artery stenosis. Methods: A total of 204 proximal atherosclerotic extracranial vertebral artery stenosis patients underwent stent implantation at Fuwai Hospital were enrolled consecutively between August 2007 and June 2014 prospectively. Medical records were collected and the clinical results were obtained through outpatient and telephone follow up. Results: (1) The patients were (64.1±7.9) years old, and 179 were male (87...
January 25, 2017: Zhonghua Xin Xue Guan Bing za Zhi
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