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https://www.readbyqxmd.com/read/29766384/increased-functional-meg-connectivity-as-a-hallmark-of-mri-negative-focal-and-generalized-epilepsy
#1
Yiwen Li Hegner, Justus Marquetand, Adham Elshahabi, Silke Klamer, Holger Lerche, Christoph Braun, Niels K Focke
Epilepsy is one of the most prevalent neurological diseases with a high morbidity. Accumulating evidence has shown that epilepsy is an archetypical neural network disorder. Here we developed a non-invasive cortical functional connectivity analysis based on magnetoencephalography (MEG) to assess commonalities and differences in the network phenotype in different epilepsy syndromes (non-lesional/cryptogenic focal and idiopathic/genetic generalized epilepsy). Thirty-seven epilepsy patients with normal structural brain anatomy underwent a 30-min resting state MEG measurement with eyes closed...
May 15, 2018: Brain Topography
https://www.readbyqxmd.com/read/29756278/sleep-related-motor-and-behavioral-disorders-recent-advances-and-new-entities
#2
REVIEW
David P Breen, Birgit Högl, Alfonso Fasano, Claudia Trenkwalder, Anthony E Lang
Patients with sleep-related motor and behavioral disorders present to a variety of subspecialty clinics (neurology, sleep medicine, respiratory medicine, psychiatry). Diagnosing these disorders can be difficult, and sometimes they have a significant impact on quality of life. Alongside a number of common and well-recognized conditions, several new disease entities have been described in recent years that present with abnormal nocturnal motor phenomena (such as ADCY5-associated disease and anti-IgLON5 disease)...
May 14, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29740268/study-of-resting-state-functional-connectivity-networks-using-eeg-electrodes-position-as-seed
#3
Gonzalo M Rojas, Carolina Alvarez, Carlos E Montoya, María de la Iglesia-Vayá, Jaime E Cisternas, Marcelo Gálvez
Electroencephalography (EEG) is the standard diagnosis method for a wide variety of diseases such as epilepsy, sleep disorders, encephalopathies, and coma, among others. Resting-state functional magnetic resonance (rs-fMRI) is currently a technique used in research in both healthy individuals as well as patients. EEG and fMRI are procedures used to obtain direct and indirect measurements of brain neural activity: EEG measures the electrical activity of the brain using electrodes placed on the scalp, and fMRI detects the changes in blood oxygenation that occur in response to neural activity...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29738522/de-novo-and-inherited-private-variants-in-map1b-in-periventricular-nodular-heterotopia
#4
Erin L Heinzen, Adam C O'Neill, Xiaolin Zhu, Andrew S Allen, Melanie Bahlo, Jamel Chelly, William B Dobyns, Saskia Freytag, Renzo Guerrini, Richard J Leventer, Annapurna Poduri, Stephen P Robertson, Christopher A Walsh, Mengqi Zhang
Periventricular nodular heterotopia (PVNH) is a malformation of cortical development commonly associated with epilepsy. We exome sequenced 202 individuals with sporadic PVNH to identify novel genetic risk loci. We first performed a trio-based analysis and identified 219 de novo variants. Although no novel genes were implicated in this initial analysis, PVNH cases were found overall to have a significant excess of nonsynonymous de novo variants in intolerant genes (p = 3.27x10-7), suggesting a role for rare new alleles in genes yet to be associated with the condition...
May 8, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29692970/language-recovery-after-epilepsy-surgery-of-the-broca-s-area
#5
Lilit Mnatsakanyan, Sumeet Vadera, Christopher W Ingalls, Jie Zheng, Mona Sazgar, Frank P Hsu, Jack J Lin
Epilepsy surgery is indicated in select patients with drug-resistant focal epilepsy. Seizure freedom or significant reduction of seizure burden without risking new neurological deficits is the expected goal of epilepsy surgery. Typically, when the seizure onset zone overlaps with eloquent cortex, patients are excluded from surgery. We present a patient with drug-resistant frontal lobe epilepsy who underwent successful surgery with resection of Broca's area, primarily involving the pars triangularis (BA 45)...
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29681927/altered-structural-and-functional-connectivity-of-juvenile-myoclonic-epilepsy-an-fmri-study
#6
Chengqing Zhong, Rong Liu, Cheng Luo, Sisi Jiang, Li Dong, Rui Peng, Fuqiang Guo, Pu Wang
The aim of this study was to investigate the structural and functional connectivity (FC) of juvenile myoclonic epilepsy (JME) using resting state functional magnetic resonance imaging (rs-fMRI). High-resolution T1-weighted magnetic resonance imaging (MRI) and rs-fMRI data were collected in 25 patients with JME and in 24 control subjects. A FC analysis was subsequently performed, with seeding at the regions that demonstrated between-group differences in gray matter volume (GMV). Then, the observed structural and FCs were associated with the clinical manifestations...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29677585/age-at-epilepsy-onset-in-patients-with-focal-cortical-dysplasias-gangliogliomas-and-dysembryoplastic-neuroepithelial-tumours
#7
Attila Rácz, Andreas-Markus Müller, Johannes Schwerdt, Albert Becker, Hartmut Vatter, Christian E Elger
PURPOSE: The age at epilepsy onset in patients with inborn or very early acquired brain lesions depends on the epileptogenic potential of the lesion and the patients' individual "susceptibility" to epileptic seizures. To gain insight into these determinants, we analysed the case history of patients with focal cortical dysplasias (FCDs) and neuroglial tumours. METHODS: In a systematic, retrospective analysis comprised of 233 patients who underwent surgery (116 with FCDs and 117 with neuroglial tumours), we evaluated the age at epilepsy onset according to histopathologic subgroups, lesion location and family history...
April 4, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29673722/density-spectral-array-of-bis-vista%C3%A2-monitoring-system-in-a-functional-hemispherectomy
#8
C Luis, E Vilà, L Moltó, A Pardo, J L Fernández Candila, S Pacreu
We present the case of an adult patient with drug-resistant epilepsy caused by extensive inflammation in the right cerebral hemisphere. She was scheduled to undergo right functional hemispherectomy, which is common in pediatric surgery, but about which few studies have been published with respect to adult patients. During the intraoperative period, the density spectral array of the bilateral bispectral index (BIS) VISTATM monitoring system was used. We observed a power increase in low frequency (0.1-4Hz) and alpha bands (8-12Hz) in the right hemisphere, where the epileptogenic focus was...
April 16, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29658987/does-bilingualism-increase-brain-or-cognitive-reserve-in-patients-with-temporal-lobe-epilepsy
#9
Anny Reyes, Brianna M Paul, Anisa Marshall, Yu-Hsuan A Chang, Naeim Bahrami, Leena Kansal, Vicente J Iragui, Evelyn S Tecoma, Tamar H Gollan, Carrie R McDonald
OBJECTIVE: Bilingual healthy adults have been shown to exhibit an advantage in executive functioning (EF) that is associated with microstructural changes in white matter (WM) networks. Patients with temporal lobe epilepsy (TLE) often show EF deficits that are associated with WM compromise. In this study, we investigate whether bilingualism can increase cognitive reserve and/or brain reserve in bilingual patients with TLE, mitigating EF impairment and WM compromise. METHODS: Diffusion tensor imaging was obtained in 19 bilingual and 26 monolingual patients with TLE, 12 bilingual healthy controls (HC), and 21 monolingual HC...
April 16, 2018: Epilepsia
https://www.readbyqxmd.com/read/29651571/correlation-of-neuropsychological-and-metabolic-changes-after-epilepsy-surgery-in-patients-with-left-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#10
Canan Güvenç, Patrick Dupont, Jan Van den Stock, Laura Seynaeve, Kathleen Porke, Eva Dries, Karen Van Bouwel, Johannes van Loon, Tom Theys, Karolien E Goffin, Wim Van Paesschen
BACKGROUND: Epilepsy surgery often causes changes in cognition and cerebral glucose metabolism. Our aim was to explore relationships between pre- and postoperative cerebral metabolism as measured with 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) and neuropsychological test scores in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), who were rendered seizure-free after epilepsy surgery. RESULTS: Thirteen patients were included...
April 12, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29625846/maturational-changes-of-gamma-aminobutyric-acid-a-receptors-measured-with-benzodiazepine-binding-of-iodine-123-iomazenil-single-photon-emission-computed-tomography
#11
Satoru Ikemoto, Shin-Ichiro Hamano, Yuko Hirata, Ryuki Matsuura, Kenjiro Kikuchi
BACKGROUND: Iodine 123 (I-123) iomazenil is a specific ligand of the central benzodiazepine receptor, which is a part of the postsynaptic gamma-aminobutyric acid A receptor complex. We performed statistical image processing of I-123 iomazenil single-photon emission computed tomography to elucidate maturational changes in the GABAergic system. METHODS: Thirty patients (18 boys and 12 girls, aged 17 days to 14 years) with cryptogenic focal epilepsy were enrolled and underwent I-123 iomazenil single-photon emission computed tomography...
April 3, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29625366/serial-changes-in-the-paroxysmal-discharges-in-rolandic-epilepsy-may-predict-seizure-recurrence-a-retrospective-3-year-follow-up-study
#12
Ebru Arhan, Ayse Serdaroglu, Zeynep Ozturk, Kursad Aydın, Tugba Hırfanoglu
OBJECTIVE: The aim of this study was to assess the electrographic criteria related to seizure recurrence and determine age-related seizure recurrence in children with rolandic epilepsy under long-term follow-up. METHODS: We retrospectively analyzed the data belonging to 109 patients with rolandic epilepsy with sufficient information regarding disease course and follow-up duration longer than 3years. Patients were divided into two categories: Group A (n: 75), comprised of "patients having fewer than four seizures", and Group B (n: 34), the "recurrence group comprised of patients having more than four seizures in the first three months"...
April 3, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29625365/morphometric-mri-features-and-surgical-outcome-in-patients-with-epilepsy-related-to-hippocampal-sclerosis-and-low-intellectual-quotient
#13
Larissa Botelho Gaça, Maria Teresa Fernandes Castilho Garcia, Gabriel Barbosa Sandim, Idaiane Batista Assumption Leme, Maria Helena Silva Noffs, Henrique Carrete, Ricardo Silva Centeno, João Ricardo Sato, Elza Márcia Targas Yacubian
OBJECTIVE: The objectives of this study were to verify in a series of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) if those with low intellectual quotient (IQ) levels have more extended areas of atrophy compared with those with higher IQ levels and to analyze whether IQ could be a variable implicated on a surgical outcome. MATERIAL AND METHODS: Patients (n=106) with refractory MTLE-HS submitted to corticoamygdalohippocampectomy (CAH) (57 left mesial temporal lobe epilepsy (MTLE); 45 males) were enrolled...
April 3, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29620012/rapid-antiepileptic-drug-withdrawal-may-obscure-localizing-information-obtained-during-presurgical-eeg-recordings
#14
Yulia Novitskaya, Mandy Hitz, Andreas Schulze-Bonhage
Withdrawal of antiepileptic drugs (AEDs) is a standard procedure during presurgical epilepsy assessment. Rapid and, at times, even pre-hospital withdrawal of medication is performed in some centres to enhance the yield of recorded seizures during video-EEG monitoring. AED withdrawal, however, affects the propensity and speed of propagation of epileptic activity, may evoke more severe seizures, and may cause pitfalls in EEG interpretation. We report a case which had been recommended to undergo intracranial EEG recordings in order to clarify apparently discordant MRI findings and ictal EEG patterns when monitoring was performed following complete AED withdrawal...
April 5, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29618099/surgical-treatment-of-extratemporal-epilepsy-results-and-prognostic-factors
#15
Daniel Delev, Bernhard Oehl, Bernhard J Steinhoff, Julia Nakagawa, Christian Scheiwe, Andreas Schulze-Bonhage, Josef Zentner
BACKGROUND: Surgery is a widely accepted option for the treatment of pharmacoresistant epilepsies of extratemporal origin. OBJECTIVE: To analyze clinical and epileptological results and to provide prognostic factors influencing seizure outcome. METHODS: This retrospective single-center study comprises a consecutive series of 383 patients, most of whom had an identifiable lesion on MRI, who underwent resective surgery for extratemporal epilepsy...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29605698/left-frontal-meningioangiomatosis-associated-with-type-iiic-focal-cortical-dysplasia-causing-refractory-epilepsy-and-literature-review
#16
Alexandre Roux, Charles Mellerio, Emmanuelle Lechapt-Zalcman, Megan Still, Michel Zerah, Marie Bourgeois, Johan Pallud
BACKGROUND: We report the surgical management of a lesional drug-resistant epilepsy caused by a meningioangiomatosis associated with a type IIIc focal cortical dysplasia located in the left supplementary motor area in a young male patient. CASE DESCRIPTION: A first anatomical-based partial surgical resection was performed at 11 years old under general anaesthesia without intraoperative mapping, which allowed for postoperative seizure control (Engel IA) for six years...
March 29, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29604610/long-term-outcome-after-epilepsy-surgery-in-older-adults
#17
Johannes D Lang, Laura Grell, Mareike Hagge, Müjgan Dogan Onugoren, Stephanie Gollwitzer, Wolfgang Graf, Michael Schwarz, Roland Coras, Ingmar Blümcke, Björn Sommer, Karl Rössler, Michael Buchfelder, Stefan Schwab, Hermann Stefan, Hajo M Hamer
PURPOSE: The incidence of epilepsy in older adults is growing, as does the incidence of comorbidities. Therefore, when it comes to epilepsy surgery in medically intractable epilepsy, age is often seen as a limiting factor. To investigate the outcome after epilepsy surgery in a population of older adults, we compared the benefit for patients aged 50-59 years with those aged 60 years and older in respect of efficacy and safety. METHOD: Patients aged ≥50 years with medically intractable epilepsy who underwent epilepsy surgery from 1990 to 2013 were selected from the database of a German epilepsy center...
March 6, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29594410/-18-f-fdg-pet-in-drug-resistant-epilepsy-due-to-focal-cortical-dysplasia-type-2-additional-value-of-electroclinical-data-and-coregistration-with-mri
#18
Serge Desarnaud, Charles Mellerio, Franck Semah, Agathe Laurent, Elisabeth Landre, Bertrand Devaux, Catherine Chiron, Vincent Lebon, Francine Chassoux
PURPOSE: To assess the localizing value of18 F-FDG PET in patients operated on for drug-resistant epilepsy due to focal cortical dysplasia type 2 (FCD2 ). METHODS: We analysed18 F-FDG PET scans from 103 consecutive patients (52 males, 7-65 years old) with histologically proven FCD2 . PET and MRI data were first reviewed by visual analysis blinded to clinical information and FCD2 location. The additional value of electroclinical data and PET/MRI coregistration was assessed by comparison with pathological results and surgical outcomes...
March 29, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29588979/claustrum-hyperintensities-a-potential-clue-to-autoimmune-epilepsy
#19
Claude Steriade, David F Tang-Wai, Timo Krings, Richard Wennberg
In a cohort of 34 patients with autoimmune limbic encephalitis and/or epilepsy, we identified 4 patients exhibiting claustrum fluid-attenuated inversion recovery (FLAIR) hyperintensities. All 4 patients presented with explosive onset of seizures and developed medically intractable epilepsy, and 2 exhibited a marked response to immunotherapy. Associated features included cognitive and behavioral disturbances (4/4), cerebrospinal fluid (CSF) lymphocytic pleocytosis (3/4), and a neural autoantibody (2/4). Electroencephalogram (EEG) features consisted of slow wave activity and epileptiform discharges in frontal and parasagittal regions, where ictal patterns were captured in 1 patient...
December 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29588950/decreased-functional-connectivity-within-a-language-subnetwork-in-benign-epilepsy-with-centrotemporal-spikes
#20
Colm J McGinnity, Anna B Smith, Siti N Yaakub, Sofia Weidenbach Gerbase, Anya Gammerman, Adam L Tyson, Tiffany K Bell, Marwa Elmasri, Gareth J Barker, Mark P Richardson, Deb K Pal
Objective: Benign epilepsy with centrotemporal spikes (BECTS, also known as Rolandic epilepsy) is a common epilepsy syndrome that is associated with literacy and language impairments. The neural mechanisms of the syndrome are not known. The primary objective of this study was to test the hypothesis that functional connectivity within the language network is decreased in children with BECTS. We also tested the hypothesis that siblings of children with BECTS have similar abnormalities. Methods: Echo planar magnetic resonance (MR) imaging data were acquired from 25 children with BECTS, 12 siblings, and 20 healthy controls, at rest...
June 2017: Epilepsia Open
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