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https://www.readbyqxmd.com/read/22280460/structural-basis-for-telomeric-g-quadruplex-targeting-by-naphthalene-diimide-ligands
#1
Gavin W Collie, Rossella Promontorio, Sonja M Hampel, Marialuisa Micco, Stephen Neidle, Gary N Parkinson
The folding of the single-stranded 3' end of the human telomere into G-quadruplex arrangements inhibits the overhang from hybridizing with the RNA template of telomerase and halts telomere maintenance in cancer cells. The ability to thermally stabilize human telomeric DNA as a four-stranded G-quadruplex structure by developing selective small molecule compounds is a therapeutic path to regulating telomerase activity and thereby selectively inhibit cancer cell growth. The development of compounds with the necessary selectivity and affinity to target parallel-stranded G-quadruplex structures has proved particularly challenging to date, relying heavily upon limited structural data...
February 8, 2012: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/13420605/-epidemiological-studies-of-kala-azar-in-the-promontorio-garganico-puglie-province-of-foggia
#2
A CORRADETTI, G SACCA, I NERI
No abstract text is available yet for this article.
1956: Rendiconti—Istituto Superiore di Sanità
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