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https://www.readbyqxmd.com/read/27902597/whole-exome-sequencing-of-independent-lung-adenocarcinoma-lung-squamous-cell-carcinoma-and-malignant-peritoneal-mesothelioma-a-case-report
#1
Irene Vanni, Simona Coco, Silvia Bonfiglio, Davide Cittaro, Carlo Genova, Federica Biello, Marco Mora, Valeria Rossella, Maria Giovanna Dal Bello, Anna Truini, Barbara Banelli, Dejan Lazarevic, Angela Alama, Erika Rijavec, Giulia Barletta, Francesco Grossi
The presence of multiple primary tumors (MPT) in a single patient has been identified with an increasing frequency. A critical issue is to establish if the second tumor represents an independent primary cancer or a metastasis. Therefore, the assessment of MPT clonal origin might help understand the disease behavior and improve the management/prognosis of the patient.Herein, we report a 73-year-old male smoker who developed 2 primary lung cancers (adenocarcinoma and squamous cell carcinoma) and a malignant peritoneal mesothelioma (PM)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27899978/analysis-of-clinicopathological-characteristics-associated-with-the-outcome-of-oral-squamous-cell-carcinoma-and-the-establishment-of-tissue-microarrays
#2
Xin Jin, Dongjuan Liu, Xin Zhao, Yu Zhou, Lu Jiang, Jing Li, Xin Zeng, Qianming Chen
The aim of this study was to evaluate clinicopathological risk factors associated with the fatal outcome of oral squamous cell carcinoma (OSCC) in a large cohort of Chinese patients, and to construct tissue microarrays (TMAs) using this cohort. Univariate and multiple logistic regression analyses were performed to evaluate the predictors of poor prognosis in a cohort of 232 patients with OSCC, after which the patient tumor tissues were used to construct TMAs. Univariate logistic regression analysis indicated that a poor outcome of OSCC was associated with the male gender, a history of smoking, the tumor-node-metastasis stage and lymph node metastasis...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27894089/associations-between-single-nucleotide-polymorphisms-of-human-exonuclease-1-and-the-risk-of-hepatocellular-carcinoma
#3
Shengkui Tan, Ruoyun Qin, Xiaonian Zhu, Chao Tan, Jiale Song, Linyuan Qin, Liu Liu, Xiong Huang, Anhua Li, Xiaoqiang Qiu
Human exonuclease 1 (hEXO1) is an important nuclease involved in mismatch repair system that contributes to maintain genomic stability and modulate DNA recombination. This study is aimed to explore the associations between single-nucleotide polymorphisms (SNPs) of hEXO1 and the hereditary susceptibility of hepatocellular carcinoma (HCC). SNPs rs1047840, rs1776148, rs3754093, rs4149867, rs4149963, and rs1776181 of hEXO1 were examined from a hospital-based case-control study including 1,196 cases (HCC patients) and 1,199 controls (non-HCC patients) in Guangxi, China...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27835577/a-functional-variant-rs4442975-modulating-foxa1-binding-affinity-does-not-influence-the-risk-or-progression-of-breast-cancer-in-chinese-han-population
#4
Yi Zhang, Yan Li, Shaojie Jiang, Wei Chen, Jiao Lou, Juntao Ke, Jiaoyuan Li, Ying Zhu, Yajie Gong, Yang Yang, Jianbo Tian, Xiating Peng, Danyi Zou, Jing Gong, Jiang Chang, Xiaoping Miao, Rong Zhong
The DNA-binding protein FOXA1 has been shown to regulate nearly all estrogen receptor-chromatin interactions, thereby influencing target gene expression levels in breast cancer (BC) cells. Recently, the rs4442975 T-allele, which disrupts the recruitment of FOXA1 and interacts with the IGFBP5 promoter, was associated to BC susceptibility in a European population. We conducted a hospital-based case-control study that included 1227 cases and 1285 controls to explore the potential association between rs4442975 and BC risk in Chinese Han population, and the effect of this SNP on BC progression was also observed in cases...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27807803/choriocarcinoma-syndrome-after-resection-of-primary-pulmonary-choriocarcinoma-report-of-a-case
#5
Tsuyoshi Takahashi, Ryo Kobayashi
BACKGROUND: Choriocarcinoma syndrome is known as a lethal complication from tumoral hemorrhage, which frequently occurs at the site of tumor metastasis. CASE PRESENTATION: A 59-year-old man with 60-pack-year smoking history was referred to our hospital because of hemoptysis. Chest computed tomography (CT) showed a 28 × 18 mm spiculated nodule with a cavity infiltrating the left upper lobe. A transbronchial lung biopsy was performed, and histopathological examinations revealed adenocarcinoma...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27784305/emerging-roles-of-t-helper-17-and-regulatory-t-cells-in-lung-cancer-progression-and-metastasis
#6
REVIEW
Erin A Marshall, Kevin W Ng, Sonia H Y Kung, Emma M Conway, Victor D Martinez, Elizabeth C Halvorsen, David A Rowbotham, Emily A Vucic, Adam W Plumb, Daiana D Becker-Santos, Katey S S Enfield, Jennifer Y Kennett, Kevin L Bennewith, William W Lockwood, Stephen Lam, John C English, Ninan Abraham, Wan L Lam
Lung cancer is a leading cause of cancer-related deaths worldwide. Lung cancer risk factors, including smoking and exposure to environmental carcinogens, have been linked to chronic inflammation. An integral feature of inflammation is the activation, expansion and infiltration of diverse immune cell types, including CD4(+) T cells. Within this T cell subset are immunosuppressive regulatory T (Treg) cells and pro-inflammatory T helper 17 (Th17) cells that act in a fine balance to regulate appropriate adaptive immune responses...
October 27, 2016: Molecular Cancer
https://www.readbyqxmd.com/read/27783167/clinicopathological-features-of-siewert-type-ii-adenocarcinoma-comparison-of-gastric-cardia-adenocarcinoma-and-barrett-s-esophageal-adenocarcinoma-following-endoscopic-submucosal-dissection
#7
Hiroki Osumi, Junko Fujisaki, Masami Omae, Tomoki Shimizu, Toshiyuki Yoshio, Akiyoshi Ishiyama, Toshiaki Hirasawa, Tomohiro Tsuchida, Yorimasa Yamamoto, Hiroshi Kawachi, Noriko Yamamoto, Masahiro Igarashi
OBJECTIVES: Siewert type II esophagogastric junction adenocarcinoma encompasses both gastric cardia adenocarcinoma (GCA) and Barrett's esophageal adenocarcinoma (BEA) due to short-segment Barrett's esophagus. We compared these two types of Siewert type II esophagogastric junction adenocarcinoma in terms of background factors and clinical outcomes of endoscopic submucosal dissection (ESD). METHODS: We enrolled 139 patients (142 lesions) who underwent ESD from 2006 to 2014 at our institution...
October 25, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27767028/genomic-heterogeneity-of-multiple-synchronous-lung-cancer
#8
Yu Liu, Jianjun Zhang, Lin Li, Guangliang Yin, Jianhua Zhang, Shan Zheng, Hannah Cheung, Ning Wu, Ning Lu, Xizeng Mao, Longhai Yang, Jiexin Zhang, Li Zhang, Sahil Seth, Huang Chen, Xingzhi Song, Kan Liu, Yongqiang Xie, Lina Zhou, Chuanduo Zhao, Naijun Han, Wenting Chen, Susu Zhang, Longyun Chen, Wenjun Cai, Lin Li, Miaozhong Shen, Ningzhi Xu, Shujun Cheng, Huanming Yang, J Jack Lee, Arlene Correa, Junya Fujimoto, Carmen Behrens, Chi-Wan Chow, William N William, John V Heymach, Waun Ki Hong, Stephen Swisher, Ignacio I Wistuba, Jun Wang, Dongmei Lin, Xiangyang Liu, P Andrew Futreal, Yanning Gao
Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent tumours. In this study we analyse genomic profiles of 15 lung adenocarcinomas and one regional lymph node metastasis from 6 patients with MSLC. All 15 lung tumours demonstrate distinct genomic profiles, suggesting all are independent primary tumours, which are consistent with comprehensive histopathological assessment in 5 of the 6 patients. Lung tumours of the same individuals are no more similar to each other than are lung adenocarcinomas of different patients from TCGA cohort matched for tumour size and smoking status...
October 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27750372/copy-number-gain-of-11q13-3-genes-associates-with-pathological-stage-in-hypopharyngeal-squamous-cell-carcinoma
#9
Samuel B Pattle, Natasa Utjesanovic, Athena Togo, Lucy Wells, Brendan Conn, Hannah Monaghan, Elizabeth Junor, Ingolfur Johannessen, Kate Cuschieri, Simon Talbot
Squamous cell carcinomas of the hypopharynx (HPSCC) and oropharynx (OPSCC) have markedly different patient outcomes. Differences in HPV prevalence between these two patient groups may account for some of this difference, but other molecular markers of prognosis or pathological phenotype have not been established. Copy number gain of oncogenes is a well-established molecular change contributing to HNSCC development. Quantitative PCR was used to explore copy number gains of specific genes (3q-PIK3CA, TP63; 11q13...
October 17, 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27747151/a-long-term-survivor-of-non-small-cell-lung-cancer-harboring-concomitant-egfr-mutation-and-alk-translocation
#10
Fumio Imamura, Takako Inoue, Madoka Kimura, Kazumi Nishino, Toru Kumagai
In January 2003, a 55-year old, non-smoking woman visited our hospital to undergo treatment for T4N0M0 pulmonary adenocarcinoma of the left lung. Until death in October 2015, she received over 20 lines of treatment including a second line therapy with gefitinib, which showed long response. In March 2014, she noticed the left axillar lymph node swelling. Aspiration cytology of the lymph node revealed the presence of adenocarcinoma harboring EGFR exon 19 deletion (Ex19del) but not T790M. Concomitant ALK translocation of variant 1 was also detected...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27747015/clinicopathological-features-and-prognosis-of-primary-pulmonary-lymphoepithelioma-like-carcinoma
#11
Wen-Yang Jiang, Rui Wang, Xu-Feng Pan, Yu-Zhou Shen, Tian-Xiang Chen, Yun-Hai Yang, Jin-Cheng Shao, Lei Zhu, Bao-Hui Han, Jun Yang, Heng Zhao
BACKGROUND: Lymphoepithelioma-like carcinoma (LELC) is a rare form of non-small cell lung carcinoma. The current study focused on its clinicopathological features and potential factors influencing the prognosis. METHODS: The statistical analysis was based on the clinicopathological records and the prognosis of 43 LELC patients, analyzed by Kaplan-Meier method, Log-rank test, and COX regression analysis. RESULTS: The patients' average age was 57...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27741355/multi-institutional-experience-of-stereotactic-body-radiotherapy-for-large-%C3%A2-5-centimeters-non-small-cell-lung-tumors
#12
Vivek Verma, Valerie K Shostrom, Sameera S Kumar, Weining Zhen, Christopher L Hallemeier, Steve E Braunstein, John Holland, Matthew M Harkenrider, Adrian S Iskhanian, Hanmanth J Neboori, Salma K Jabbour, Albert Attia, Percy Lee, Fiori Alite, Joshua M Walker, John M Stahl, Kyle Wang, Brian S Bingham, Christina Hadzitheodorou, Roy H Decker, Ronald C McGarry, Charles B Simone
BACKGROUND: Stereotactic body radiotherapy (SBRT) is the standard of care for patients with nonoperative, early-stage non-small cell lung cancer (NSCLC) measuring < 5 cm, but its use among patients with tumors measuring ≥5 cm is considerably less defined, with the existing literature limited to small, single-institution reports. The current multi-institutional study reported outcomes evaluating the largest such population reported to date. METHODS: Clinical/treatment characteristics, outcomes, toxicities, and patterns of failure were assessed in patients with primary NSCLC measuring ≥5 cm without evidence of distant/lymph node metastasis who underwent SBRT using ≤5 fractions...
October 14, 2016: Cancer
https://www.readbyqxmd.com/read/27734981/malignant-salivary-gland-tumours-of-the-larynx-a-single-institution-review
#13
S Karatayli-Ozgursoy, J A Bishop, A T Hillel, L M Akst, S R Best
Malignant salivary gland tumours of the larynx are very rare, with limited reports of clinical outcomes. We present the decade-long experience of a single institution. A 10-year retrospective chart review of a tertiary head and neck cancer centre was performed. Index patients were identified from a review of a pathology database, and reviewed by a head and neck pathologist. Patient demographics, presenting signs and symptoms, treatment modalities and clinical outcomes were extracted from electronic medical records...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27729745/programmed-death-ligand-1-expression-and-its-prognostic-role-in-esophageal-squamous-cell-carcinoma
#14
Ryul Kim, Bhumsuk Keam, Dohee Kwon, Chan-Young Ock, Miso Kim, Tae Min Kim, Hak Jae Kim, Yoon Kyung Jeon, In Kyu Park, Chang Hyun Kang, Dong-Wan Kim, Young Tae Kim, Dae Seog Heo
AIM: To investigate the expression and prognostic role of programmed death ligand-1 (PD-L1) in locally advanced esophageal squamous cell carcinoma (ESCC). METHODS: A total of 200 patients with ESCC who underwent radical esophagectomy with standard lymphadenectomy as the initial definitive treatment in Seoul National University Hospital from December 2000 to April 2013 were eligible for this analysis. Tissue microarrays were constructed by collecting tissue cores from surgical specimens, and immunostained with antibodies directed against PD-L1, p16, and c-Met...
October 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27726294/role-of-comorbidity-on-outcome-of-head-and-neck-cancer-a-population-based-study-in-thuringia-germany
#15
Irene Göllnitz, Johanna Inhestern, Thomas G Wendt, Jens Buentzel, Dirk Esser, Daniel Böger, Andreas H Mueller, Jörn-Uwe Piesold, Stefan Schultze-Mosgau, Ekkehard Eigendorff, Peter Schlattmann, Orlando Guntinas-Lichius
To examine the impact of comorbidity on overall survival (OS) in a population-based study of patients with head and neck cancer who were treated between 2009 and 2011. Data of 1094 patients with primary head and neck carcinomas without distant metastasis from the Thuringian cancer registries were evaluated concerning the influence of patient's characteristics and comorbidity on OS. Data on comorbidity prior to head and neck cancer diagnosis was adapted to the Charlson Comorbidity (CCI), age-adjusted CCI (ACCI), head and neck CCI (HNCCI), simplified comorbidity score (SCS), and to the Adult Comorbidity Evaluation-27 (ACE-27)...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27720649/clinicopathologic-evaluation-of-malignancy-adjacent-to-dental-implants
#16
Ilana Kaplan, Itai Zeevi, Haim Tal, Eli Rosenfeld, Gavriel Chaushu
OBJECTIVE: The aim of this study was to describe a new case series of peri-implant malignancy, review the literature, and discuss the implications of malignancies resembling peri-implantitis. STUDY DESIGN: This study was a retrospective analysis of cases from 2000 to 2016. RESULTS: Seven patients (two males and five females), aged 44 to 89 years, were included, representing 1.5% of oral malignancy cases. Five cases were squamous carcinoma, one of basal cell carcinoma, and one of carcinoma of metastatic origin...
September 9, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27681476/squamous-cell-carcinoma-complicating-a-chronic-lesion-of-hidradenitis-suppurativa-a-case-report-and-review-of-the-literature
#17
Natanel Jourabchi, Alexander H Fischer, Ashley Cimino-Mathews, Kevin M Waters, Ginette A Okoye
Squamous cell carcinoma (SCC) arising from chronic hidradenitis suppurativa (HS) is rare; however, the morbidity associated with this presentation is high and management has not been standardised or optimised. We present a case of HS of the perineum and buttocks complicated by SCC, requiring multiple extensive surgical resections. Adjuvant radiotherapy was withheld initially because of concern for poor healing of the surgical wound but was eventually initiated after a second recurrence was identified. The patient ultimately expired 4 years after the initial diagnosis of SCC...
September 29, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27592612/pulmonary-anthracosis-mimicking-lung-metastases-in-pediatric-rhabdomyosarcoma
#18
Gabrielle Karpinsky, Malgorzata Anna Krawczyk, Aleksandra Fatyga, Ewa Izycka-Swieszewska, Miroslawa Dubaniewicz-Wybieralska, Dagmara Szmyd, Monika Luboch-Furmanczyk, Ewa Bien
Although childhood rhabdomyosarcoma typically metastasizes to lungs, various processes may mimic metastatic etiology. Described herein is the case of an 8½-year-old boy with orbital embryonal rhabdomyosarcoma (RME) in whom three small foci were detected within both lungs on computed tomography. The lesion number and size, however, did not fulfil the Cooperative Weichteilsarkom Study Group 2006 protocol criteria for lung metastasis. Chemotherapy for localized RME produced primary tumor regression and vanishing of the left lung lesion...
September 5, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27575421/clinicopathological-immunohistochemical-and-genetic-features-of-primary-lung-adenocarcinoma-occurring-in-the-setting-of-usual-interstitial-pneumonia-pattern
#19
Kyohei Masai, Koji Tsuta, Noriko Motoi, Kouya Shiraishi, Koh Furuta, Shigeki Suzuki, Keisuke Asakura, Kazuo Nakagawa, Hiroyuki Sakurai, Shun-Ichi Watanabe, Nobuyoshi Hiraoka, Hisao Asamura
INTRODUCTION: An association between usual interstitial pneumonia (UIP) and carcinogenesis has been well established. However, few detailed analyses have investigated the clinicopathological, immunohistochemical, and genetic features of patients with primary lung adenocarcinoma (ADC) with UIP (UIP-ADC). METHODS: We identified 44 patients with ADC in the setting of UIP (the UIP-ADC group) (1.9%) from 2309 patients with primary ADC and compared clinicopathological, immunohistochemical, and genetic features between the UIP-ADC group and patients with ADC without UIP (the non-UIP-ADC group)...
December 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27542207/chronic-exposure-to-cigarette-smoke-leads-to-activation-of-p21-rac1-activated-kinase-6-pak6-in-non-small-cell-lung-cancer-cells
#20
Remya Raja, Nandini A Sahasrabuddhe, Aneesha Radhakrishnan, Nazia Syed, Hitendra S Solanki, Vinuth N Puttamallesh, Sai A Balaji, Vishalakshi Nanjappa, Keshava K Datta, Niraj Babu, Santosh Renuse, Arun H Patil, Evgeny Izumchenko, T S Keshava Prasad, Xiaofei Chang, Annapoorni Rangarajan, David Sidransky, Akhilesh Pandey, Harsha Gowda, Aditi Chatterjee
Epidemiological data clearly establishes cigarette smoking as one of the major cause for lung cancer worldwide. Recently, targeted therapy has become one of the most preferred modes of treatment for cancer. Though certain targeted therapies such as anti-EGFR are in clinical practice, they have shown limited success in lung cancer patients who are smokers. This demands discovery of alternative drug targets through systematic investigation of cigarette smoke-induced signaling mechanisms. To study the signaling events activated in response to cigarette smoke, we carried out SILAC-based phosphoproteomic analysis of H358 lung cancer cells chronically exposed to cigarette smoke...
August 16, 2016: Oncotarget
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