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Smoking + metastasis

M C Mengoli, F Bertolini, M Maur, F Barbieri, L Longo, P Gasparri, M Tiseo, G Rossi
We report an ALK-rearranged adenocarcinoma of the lung presenting as a pituitary metastasis, clinically simulating a pituitary adenoma. The patient, a 50 year-old, former-smoking woman was admitted with a Parinaud's syndrome characterized by progressive oculomotor impairment of visual verticality, bitemporal hemianopsia and nystagmus. Imaging studies showed a sellar tumor and the biopsy revealed a TTF-1 and napsin positive lung adenocarcinoma strongly expressing synaptophysin and CD56, also harboring ALK rearrangement...
December 2017: Pathologica
Wei-Yuan Chang, Yi-Lin Wu, Po-Lan Su, Szu-Chun Yang, Chien-Chung Lin, Wu-Chou Su
Previous studies have demonstrated the association between EGFR mutations and distant metastasis. However, the association for subsequent brain metastasis (BM) in stages I-III non-small cell lung cancer (NSCLC) patients remains inconclusive. We conducted a retrospective analysis to clarify the impact of EGFR mutations on the incidence of BM and associated survival in patients with stage I-III NSCLC. A total of 491 patients screened for EGFR mutations were retrospectively enrolled. Brain MRI or CT was used to detect the BM...
2018: PloS One
Tian Xie, Xingyu Li, Fei Ye, Chenxi Lu, Haitao Huang, Fei Wang, Xiaolei Cao, Chongjun Zhong
The Kinesin family member 2a (KIF2A), that belongs to the Kinesin-13 microtubule depolymerases, plays an important role in cancer cell proliferation, migration and apoptosis in various types of cancer such as gastric cancer, breast cancer, and squamous cell carcinoma of the oral tongue, but, its role and mechanism in lung adenocarcinoma (LUAD) is largely unknown. The present study reported that KIF2A was overexpressed in LUAD tissues as compared with adjacent normal tissues. KIF2A was closely correlated with TNM stage and lymph node metastasis (P < 0...
February 7, 2018: Biochemical and Biophysical Research Communications
Alexandre Lafourcade, Mathilde His, Laura Baglietto, Marie-Christine Boutron-Ruault, Laure Dossus, Virginie Rondeau
BACKGROUND: In addition to tumor characteristics and lifestyle factors, cancer relapses are often related to the risk of death but have not been jointly studied. We investigate the prognostic factors of recurrent events and death after a diagnosis of breast cancer and predict individual deaths including a history of recurrences. METHODS: The E3N (Etude Epidémiologique auprès de Femmes de la Mutuelle Générale de l'Education Nationale) study is a prospective cohort study that was initiated in 1990 to investigate factors associated with the most common types of cancer...
February 9, 2018: BMC Cancer
Henriette Aurora Selvik, Anna Therese Bjerkreim, Lars Thomassen, Ulrike Waje-Andreassen, Halvor Naess, Christopher Elnan Kvistad
BACKGROUND AND PURPOSE: Ischemic stroke can be the first manifestation of cancer and it is therefore important to ascertain which stroke patients should be considered for cancer-diagnostic investigations. We aimed to determine the frequency of active cancer in patients with acute ischemic stroke and to compare clinical findings in stroke patients with active cancer to ischemic stroke patients with no history of cancer. Finally, we aimed to develop a predictive and feasible score for clinical use to uncover underlying malignancy...
January 9, 2018: Cerebrovascular Diseases
Yılmaz Özkul, Düzgün Ateş, Abdulkadir İmre, Murat Songu, Koray Balcı, Feda Bayrak, Kazım Önal
Objective: This study aimed to evaluate the recurrence and survival of patients treated with frontolateral laryngectomy for T1 and T2 glottic laryngeal carcinoma. Methods: Patients who underwent frontolateral laryngectomy for glottic laryngeal carcinoma at a tertiary hospital between March 2009 and June 2014 were included. Patient demographics, tumor stage, treatment and histopathological examination data, and adjuvant therapy details were evaluated. Results: Thirty patients with T1aN0, T1bN0, and T2N0 vocal fold carcinoma were examined...
March 2017: Turkish Archives of Otorhinolaryngology
Aya Harada Takeda, Yui Watanabe, Toshiyuki Nagata, Masaya Aoki, Tadashi Umehara, Soichi Suzuki, Go Kamimura, Kazuhiro Wakida, Tsunayuki Otsuka, Naoya Yokomakura, Kota Kariatsumari, Koichi Sakasegawa, Yoshihiro Nakamura, Masami Sato
PURPOSE: Pulmonary lymphatic fluid predominately flows along the bronchi. However, there are reports suggesting that an alternative lymphatic pathway exist, which may result in skip metastases. The aim of this study was to evaluate the subpleural lymph flow in vivo using indocyanine green (ICG) fluorescence. METHODS: One hundred cases were enrolled. ICG was injected into the macroscopically healthy subpleural space. Intraoperative fluorescence images were then observed in real time...
January 30, 2018: Surgery Today
Xiang Tan, Lei Dai, Yongyong Wang, Guanbiao Liang, Nuo Yang, Mingwu Chen
RATIONALE: Mesenchymal-to-epithelial transition (MET) exon 14 skipping mutation was a targetable alteration in nonsmall-cell lung cancer (NSCLC), and the MET inhibitor of crizotinib had the most efficacy among all the targeted drugs. Most of the cancer-related deaths are associated with metastasis. Circulating tumor cells (CTCs) have been a valuable biomarker in assessing metastasis. Recent experiences suggested that CTCs detection may help improve diagnosis and predict prognosis for patients with NSCLC...
November 2017: Medicine (Baltimore)
Ying-Chieh Su, Han Chang, Shih-Jung Sun, ChengYi Liao, Ling-Yi Wang, Jiunn-Lang Ko, Jinghua Tsai Chang
CX3CL1 is a unique chemokine, expressed in both soluble and membrane bound forms, which mediates different biological activities. Recent studies have revealed the potential of CX3CL1 signaling pathway as a target for the treatment of inflammation and cancer. The correlation between expression of CX3CL1 and prognosis of patients varies among cancers. In this study, based on CX3CL1 immunohistochemistry in non-small cell lung cancer, CX3CL1 levels were positively associated with cancer stage (Pearson chi-square, p = 0...
January 30, 2018: Molecular Carcinogenesis
Ganesan Arunkumar, Arunagiri Kuha Deva Magendhra Rao, Mayakannan Manikandan, Harikrishnan Prasanna Srinivasa Rao, Shanmugam Subbiah, Ramachandran Ilangovan, Avaniyapuram Kannan Murugan, Arasambattu Kannan Munirajan
MicroRNAs (miRNAs) are reported to function as a major component in the cellular signaling circuit, which regulates epithelial-mesenchymal transition (EMT). Dysregulation of the microRNA-200 (miR-200) family and EMT-associated genes enables tumor metastasis and resistance to therapy. The present study profiled miR-200 family members miR-200a, miR-200b, miR-200c, miR-141 and miR-429, and also several EMT-regulatory genes including zinc finger E-box-binding homeobox (ZEB)1, ZEB2, epithelial cadherin and vimentin in 40 oral primary tumors in order to understand their role(s) in oral squamous cell carcinoma (OSCC)...
January 2018: Oncology Letters
Paweł Kiczmer, Alicja Prawdzic Seńkowska, Joanna Katarzyna Strzelczyk, Błażej Szydło, Krzysztof Biernacki, Tadeusz Osadnik, Łukasz Krakowczyk, Zofia Ostrowska
Head and neck squamous cell carcinoma (HNSCC) is one of the leading cancers by incidence worldwide. The risk of these cancers is strictly associated with alkylation factors present in tobacco smoke. The crucial role in preventing DNA alkylation is played by O6-methylguanine-DNA methyltransferase (MGMT). Dysfunction or lack of MGMT is associated with an increased risk of cancer. The aim of the study was to assess the influence of MGMT polymorphisms: rs12917 and rs11016879 on HNSCC risk and course. The study consisted of 69 HNSCC patients and 242 healthy individuals...
January 25, 2018: Acta Biochimica Polonica
Amer Sebaaly, Daniel Shedid, Ghassan Boubez, Fahed Zairi, Michelle Kanhonou, Sung-Joo Yuh, Zhi Wang
BACKGROUND: Surgical site infection (SSI) inspinal metastasis surgery represents the most common postoperative surgical complication with high morbidity and mortality. OBJECTIVE: Evaluate the incidence of SSI in spinal metastasis surgery and its risk factors. STUDY DESIGN: Retrospective analysis of a prospective collected data. METHODS: Preoperative, operative and post-operative data were collected together with the Modified Tokuhashi score and Frankel score at all time checkpoints...
January 17, 2018: Spine Journal: Official Journal of the North American Spine Society
Guimei Hu, Lijun Qin, Xinjun Zhang, Guoliang Ye, Tao Huang
BACKGROUND/AIMS: Human mutL homolog 1 (MLH1) promoter methylation was reported in gastric cancer (GC). This study determined the clinicopathological, prognostic, and diagnostic effects of MLH1 promoter methylation in GC. METHODS: The combined odds ratio (OR) or hazard ratio (HR) and their corresponding 95% confidence intervals (95% CI) were calculated. The pooled sensitivity, specificity, and area under the curve (AUC) were analyzed. RESULTS: A total of 4654 GC patients and 3669 non-malignant controls were identified in this systematic analysis...
January 15, 2018: Cellular Physiology and Biochemistry
Xinjie Wu, Yingna Qi, Feng Yang, Mingsheng Tan, Jie Lin
BACKGROUND: Thymic carcinoid with spinal metastasis is an extremely rare entity. Clinically, the tumor presents either by its endocrine manifestations or by mechanical compression of surrounding structures. However, no previous studies reported a case with neck pain, and neurological deficit as initial presentation of an atypical thymic carcinoid. METHOD: A 56-year-old non-smoking man presented with 12-month history of intermittent neck pain and 1-month history of progressive numbness and weakness of the right upper limb...
January 8, 2018: World Neurosurgery
Yesol Bak, Hui-Joo Jang, Ji-Hye Seo, Su-Hyun No, Jung-Il Chae, Jintae Hong, Do-Young Yoon
Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a principal component of cigarette smoke. B[a]P can cause lung carcinogenesis and plays a key role in lung cancer progression. The role of B[a]P has been reported in lung cancer, but its effects on lung cancer stem cells have not been investigated. Emerging evidence indicates that cancer stem cells (CSCs) are associated with carcinogenesis, tumor initiation, relapse, and metastasis. Therefore, targeting CSCs to defeat cancer is a challenging issue in the clinic...
January 11, 2018: Journal of Microbiology and Biotechnology
Yikun Yang, Yousheng Mao, Lin Yang, Jie He, Shugeng Gao, Juwei Mu, Qi Xue, Dali Wang, Jun Zhao, Yushun Gao, Zhirong Zhang, Ningning Ding, Ding Yang
Background: Patients with pathological stage I (p I) lung adenocarcinoma show variabilities in prognosis even after complete resection. The factors resulting in heterogeneities of prognosis remain controversy. The aim of this study was to identify the risk factors affecting recurrence/metastasis and survival in patients with curatively resected p I lung adenocarcinoma. Methods: A total of 252 patients with p I lung adenocarcinoma underwent curative resection between January 1st, 2009 to September 30th, 2011 were retrospectively reviewed to analyze the associations of recurrence and survival with the following clinicopathological variables: gender, age, cigarette smoking, family cancer history, tumor size, TNM stage, tumor differentiation, visceral pleural invasion, bronchial involvement, lymphovascular invasion, postoperative adjuvant treatment, pathological subtypes and micropapillary pattern...
December 2017: Journal of Thoracic Disease
Min Kong, Jiang Jin, Xiuyu Cai, Jianfei Shen, Dehua Ma, Minhua Ye, Chengchu Zhu, Samuel Freedman, Kelly Walters, Xin Xu, Baofu Chen
The aim of this study was to retrospectively analyze the clinical data of resected adenosquamous lung cancer (ASLC) and to explore the influencing factors and clinicopathological characteristics of the metastasis lymph nodes. A total of 1156 consecutive patients with surgically resected lung cancer from January 2009 to June 2014 were studied. Fifty-four previously diagnosed ASLC patients were re-evaluated by experienced pathologists. IHC and H&E staining were employed to examine the primary focus and metastasis lymph nodes...
December 2017: Medicine (Baltimore)
Shuguang Wen, Wenbiao Ren, Bichen Xue, Yi Fan, Yongjun Jiang, Chunming Zeng, Yujia Li, Xiongbing Zu
PURPOSE: To examine the possible prognostic factors in patients with penile cancer after surgical management and to identify the independent predictive factors of the prognosis. MATERIALS AND METHODS: Clinical data of 135 patients with penile cancer who underwent surgical management in two medical centers were collected. Follow-up data were available for 103 patients. Possible prognostic factors including patient's age; smoking or not; course of disease; phimosis or not; type of surgery; tumor stage; nodal stage; tumor grade and pathological lymph nodes metastasis were retrospectively analyzed by univariate and multivariate analyses with Cox regression...
January 3, 2018: World Journal of Urology
Fadi Nemeh, Anderson H Kuo, Jenny Ross, Carlos S Restrepo
Pulmonary blastomas are rare malignancies, representing 0.25% to 0.5% of all primary lung neoplasms with often aggressive progression and poor prognosis. Clinical management of pulmonary blastomas depends on histologic subtype, staging, and presentation, and may consist of surgery, chemotherapy, and radiation. Biphasic pulmonary blastoma is a subtype of pulmonary blastoma that exhibits biphasic histology, with both epithelial and mesenchymal malignant elements. We report a case of biphasic pulmonary blastoma in a 33-year-old female with 1 pack per day history of smoking for approximately 16 years, who presented with left-sided pleuritic chest pain on deep inspiration without otherwise significant pat medical history...
September 2017: Journal of Radiology Case Reports
S C Su, M J Hsieh, C W Lin, C Y Chuang, Y F Liu, C M Yeh, S F Yang
Genetic and acquired factors are thought to be interrelated and imperative to estimate the risk and prognosis of oral squamous cell carcinoma (OSCC). HOX transcript antisense intergenic RNA ( HOTAIR) plays crucial roles in gene regulation and is regulated in a variety of cancers. Polymorphisms in HOTAIR have been recently linked to the predisposition to diverse malignancies. In the present study, we aimed to evaluate the influences of HOTAIR gene polymorphisms, combined with environmental triggers, on the susceptibility to oral tumorigenesis...
January 1, 2018: Journal of Dental Research
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