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https://www.readbyqxmd.com/read/29029446/a-potential-prognostic-biomarker-spc24-promotes-tumorigenesis-and-metastasis-in-lung-cancer
#1
Juan Zhou, Yang Yu, Yunfeng Pei, Chunping Cao, Chen Ding, Duping Wang, Li Sun, Guoping Niu
RESULTS: SPC24 is over-expressed in clinical lung adenocarcinoma samples, and high level of SPC24 is associated with advanced stages of lung tumors. Knocking down SPC24 repressed cell growth and promoted apoptosis. SPC24 deficiency reduced cancer cell migration as well. E-cadherin, one of the epithelial-mesenchymal transition markers, was up-regulated in the knockdown cells, along with down-regulation of N-cadherin and Vimentin. Oncomine expression analyses further confirmed that high level of SPC24 is associated with tumors from smokers, recurrent patients, or patients with shorter survivals...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026498/a-case-control-study-of-comparison-of-plasma-levels-of-matrix-metalloproteinase-9-in-inhaled-opium-addicts-and-clinically-healthy-persons
#2
Maryam Amizadeh, Shahryar Dabiri, Armin Javedan, Ali Eftekharian, Aliasghar Arabi-Mianroodi
BACKGROUND: Metalloproteinase-9 exists in the basement membrane of normal tissues and is a major factor in cancer invasion and lymphatic metastasis. Smoking has been reported to increase the metalloproteinase level, but the role of opium consumption in metalloproteinase level has not yet been examined. The current research intended to examine the impacts of opium consumption on the serum levels of metalloproteinase. METHODS: This case-control research was conducted in Kerman (in the southeast of Iran), after getting medical approve by the ethics committee...
January 2017: Addiction & Health
https://www.readbyqxmd.com/read/29023924/decreased-peritumoral-cd1a-cells-predicts-worse-prognosis-in-oral-squamous-cell-carcinoma
#3
Juscelino Freitas Jardim, Rogério Gondak, Marisol Miranda Galvis, Clovis Antonio Lopes Pinto, Luiz Paulo Kowalski
BACKGROUND: Dendritic cells (DCs) are known to play a central role in the regulation of both innate and adaptive immunologic responses, including antitumor immunity. This study aimed to evaluate the prognostic impact of intra and peritumoral dendritic cells in oral squamous cell carcinoma (OSCC) affecting tongue and floor of the mouth. PATIENTS AND METHODS: Immunohistochemical reactions for CD1a and CD83 were performed in 53 patients with OSCC in tongue and floor of the mouth...
October 11, 2017: Histopathology
https://www.readbyqxmd.com/read/29020937/the-prognostic-value-of-pretreatment-tumor-apparent-diffusion-coefficient-values-in-nasopharyngeal-carcinoma
#4
Dan-Fang Yan, Wen-Bao Zhang, Shan-Bao Ke, Feng Zhao, Sen-Xiang Yan, Qi-Dong Wang, Li-Song Teng
BACKGROUND: Diffusion-weighted MR imaging (DWI) has increasingly contributed to the management of nasopharyngeal carcinoma (NPC) patients. The objective of this paper was to explore the prognostic significance of apparent diffusion coefficient (ADC) values in 93 NPC patients. METHODS: This retrospective study included 93 newly diagnosed NPC patients. Pretreatment ADC values were determined and compared with patients' age, gender, alcohol intake, smoking, tumor volume, pathological type, tumor stage, and nodal stage...
October 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28983601/pkc%C3%AE-mmp%C3%A2-2-and-mmp%C3%A2-9-expression-in-lung-adenocarcinoma-and-association-with-a-metastatic-phenotype
#5
Xiaoshan Cai, Hongguang Zhu, Ying Li
The aim of the present study was to investigate protein kinase C ζ type (PKCζ), matrix metalloproteinase (MMP)‑2 and MMP‑9 expression in lung adenocarcinoma and to define their association with in vitro invasion and metastatic capacity. PKCζ, MMP‑2 and MMP‑9 expression was assessed by immunohistochemistry in 110 cases of lung adenocarcinoma. PKCζ small interfering (si)RNA was transfected into A549 cells, and western blotting was used to confirm PKCζ‑knockdown in transfected cells and to measure MMP‑2 and MMP‑9 levels...
September 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28975027/second-lung-malignancy-and-richter-syndrome-in-chronic-lymphocytic-leukemia-case-report-and-literature-review
#6
Ghassen Soussi, Selsabil Daboussi, Samira Mhamdi, Zied Moatemri, Hela Ghedira, Chiraz Aichaouia, Mohsen Khadhraoui, Faouzi El Mezni, Rezaik Cheikh
BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most frequent lymphoproliferative disease. Transformation into Richter disease and occurrence of second malignancies involving the lungs are rare complications. The hallmarks of any thoracic involvement are still unknown. CASE PRESENTATION: We report a case of a 56-year-old male patient, with history of tobacco smoking, who presented with recurrent hemoptysis, fatigue and weight loss. Physical examination was normal except a slightly enlarged supraclavicular lymph node...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28966230/difference-in-postsurgical-prognostic-factors-between-lung-adenocarcinoma-and-squamous-cell-carcinoma
#7
Haruhiko Nakamura, Hiroki Sakai, Hiroyuki Kimura, Tomoyuki Miyazawa, Hideki Marushima, Hisashi Saji
PURPOSE: The aim of this study was to compare the clinicopathologic prognostic factors between patients who underwent lung resection for adenocarcinoma (AD) and those with squamous cell carcinoma (SQ). METHODS: A database of patients with lung AD or SQ who underwent surgery with curative intent in our department from January 2008 to December 2014 was reviewed. Associations between various clinicopathologic factors, postsurgical recurrence-free survival (RFS), and overall survival (OS) were analyzed to find significant prognostic factors...
October 2, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28950357/novel-perspective-to-evaluate-the-safety-of-segmentectomy-clinical-significance-of-lobar-and-segmental-lymph-node-metastasis-in-ct1n0m0-lung-adenocarcinoma
#8
Fei Xiao, Qiduo Yu, Zhenrong Zhang, Deruo Liu, Yongqing Guo, Chaoyang Liang, Bei Wang, Hongliang Sun
OBJECTIVES: The regularity of intrapulmonary lobar and segmental lymph node (LSN) metastasis in cT1N0M0 stage lung adenocarcinoma remains unclear. Thus, segmentectomy with uncertain LSN metastatic status remains a potential oncological risk. We aimed to facilitate more accurate determination of N staging and filter more suitable cases for segmentectomy. METHODS: A prospective study was performed from March 2014 to September 2016. A total of 196 patients diagnosed with cT1N0M0 stage lung adenocarcinoma were enrolled and received lobectomy together with mediastinal lymph node dissection...
July 4, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28949965/ct-characteristics-in-pulmonary-adenocarcinoma-with-epidermal-growth-factor-receptor-mutation
#9
Jing Zhao, Julien Dinkel, Arne Warth, Roland Penzel, Niels Reinmuth, Philipp Schnabel, Thomas Muley, Michael Meister, Heike Zabeck, Martin Steins, Jian-Yong Yang, Qian Zhou, Heinz-Peter Schlemmer, Felix J F Herth, Hans-Ulrich Kauczor, Claus Peter Heussel
Comprehensively investigate the association of CT morphology and clinical findings of adenocarcinoma with EGFR mutation status. Retrospectively included 282 patients who was pathologically proved as lung adenocarcinoma with known EGFR mutation status (mutations: 138 patients, female: 86, median age: 66 years; wildtype: 144 patients, female: 67, median age: 62 years) and their pre-treatment CT scans were analyzed. CT findings and clinical information were collected. Univariate and multivariable logistic regression analysis were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28940943/associations-between-epidermal-growth-factor-receptor-mutations-and-histological-subtypes-of-lung-adenocarcinoma-according-to-the-iaslc-ats-ers-classification-in-chinese-patients
#10
Tengteng Wang, Yi Zhang, Baodong Liu, Mu Hu, Naikang Zhou, Xiuyi Zhi
BACKGROUND: This retrospective study was conducted to investigate the relationship between epidermal growth factor receptor (EGFR) mutation and histological subtypes of lung adenocarcinoma according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification in Chinese patients. METHODS: Three hundred and seventy six surgically resected lung adenocarcinomas from Chinese PLA General Hospital were included in the study...
September 20, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28940393/clinical-features-and-prognosis-of-thymic-neuroendocrine-tumors-associated-with-multiple-endocrine-neoplasia-type-1-a-single-center-study-systematic-review-and-meta-analysis
#11
Lei Ye, Weixi Wang, Naykky Singh Ospina, Lei Jiang, Ioannis Christakis, Jieli Lu, Yulin Zhou, Wei Zhu, Yanan Cao, Shu Wang, Nancy D Perrier, William F Young, Guang Ning, Weiqing Wang
OBJECTIVE: Thymic neuroendocrine tumor (TH-NET) accounts for almost 20% of multiple endocrine neoplasia type 1 (MEN1)-associated mortality. Identifying risk factors for the development of these rare tumors and prognostic factors for clinical outcomes will be helpful in clinical practice. DESIGN AND PATIENTS: We performed a retrospective analysis of patients treated for TH-NET associated with MEN1 in a single institution and meta-analysis of literature reports. We used a fixed effect model to pool results across studies to evaluate the prevalence, clinical features, and prognosis...
September 20, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28938579/the-effects-of-air-pollution-on-mortality-and-clinicopathological-features-of-esophageal-cancer
#12
Xiaochen Huang, Shanghui Guan, Jiangfeng Wang, Linli Zhao, Yibin Jia, Zilong Lu, Cuiping Yin, Shengsi Yang, Qingxu Song, Lihui Han, Cong Wang, Jingyi Li, Wei Zhou, Xiaolei Guo, Yufeng Cheng
This study aimed to estimate the associations between air pollution and esophageal cancer. In the ecologic cross-sectional study, correlation analyses were made between city-level mean concentrations of particulate matter less than 10μm in aerodynamic diameter (PM10), SO2, NO2 and city-level age-standardized mortality rates of esophageal cancer in Shandong Province, China. PM10 (p=0.046) and NO2 (p=0.03) both had significant linear correlations with esophageal cancer mortality rates. After introducing smoking as a risk factor in models of multiple linear regression analyses, PM10 was still an independent risk factor that increased esophageal cancer mortality rates...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28932565/unique-distribution-of-programmed-death-ligand-1-pd-l1-expression-in-east-asian-non-small-cell-lung-cancer
#13
Yunjian Pan, Difan Zheng, Yuan Li, Xu Cai, Zongli Zheng, Yan Jin, Haichuan Hu, Chao Cheng, Lei Shen, Jian Wang, Hongbin Ji, Yihua Sun, Xiaoyan Zhou, Haiquan Chen
BACKGROUND: To determine the proportion and clinical features of programmed death ligand 1 (PD-L1) expression in East Asian non-small cell lung cancer (NSCLC). METHODS: PD-L1 expression was assessed by immunohistochemistry (IHC) and tumor proportion score (TPS) with the use of PD-L1 IHC 22C3 antibody (Dako North America) in 108 surgically resected lung squamous cell carcinomas (SCC) and 221 lung adenocarcinomas (LUADs), and was correlated with clinical variables, histologic subtypes, and common driver mutations...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932371/estimating-postoperative-survival-rate-of-gastric-cancer-patients-and-its-effective-factors-in-babol-northern-iran-2006-2011
#14
Seyed-Reza Modarres, Abdolrahim Gholizadeh-Pasha, Soheil Khatibi, Sepideh Siadati
BACKGROUND: The importance of gastric cancer, considering its progressive course and high mortality is one of the reasons we pay attention to patients' survival and the significance of this study was to estimate survival and determine the effective factors on patients with gastric cancer. METHODS: In this cross-sectional study, all patients with gastric cancer who underwent surgery in Shahid Beheshti Hospital, Babol, northern Iran during 2006-2011 were enrolled...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28928848/primary-lymphoepithelioma-like-carcinoma-of-the-lung-an-unusual-cancer-and-clinical-outcomes-of-14-patients
#15
Lan Lin, Tingyan Lin, Bangwei Zeng
Advanced lung cancer is considered to exhibit a poor prognosis; however, the pulmonary lymphoepithelioma-like carcinoma (LELC), a rare subtype of non-small cell lung cancer (NSCLC), exhibits an improved prognosis, compared with non-LELC. The present study aimed at investigating the clinical manifestation, imaging characteristics, pathology, tumor markers, treatment and prognosis of primary LELC of the lung. A total of 14 patients with pulmonary LELC were confirmed by surgery and pathology. Clinical data of those patients were retrospectively reviewed including age, sex, smoking history, symptoms, computed tomography (CT) results, Epstein-Barr virus-encoded RNA (EBER) status, treatment and outcomes...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927526/putative-biomarkers-for-cervical-cancer-snvs-methylation-and-expression-profiles
#16
REVIEW
Maria de Fátima Senra Cardoso, Carlos Henrique Madeiros Castelletti, José Luiz de Lima-Filho, Danyelly Bruneska Gondim Martins, José António Couto Teixeira
Cervical cancer is primarily caused by Human papillomavirus (HPV) infection, but other factors such as smoking habits, co-infections and genetic background, can also contribute to its development. Although this cancer is avoidable, it is the fourth most frequent type of cancer in females worldwide and can only be treated with chemotherapy and radical surgery. There is a need for biomarkers that will enable early diagnosis and targeted therapy for this type of cancer. Therefore, a systems biology pipeline was applied in order to identify potential biomarkers for cervical cancer, which show significant reports in three molecular aspects: DNA sequence variants, DNA methylation pattern and alterations in mRNA/protein expression levels...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28923576/dose-escalation-intensity-modulated-radiotherapy-based-concurrent-chemoradiotherapy-is-effective-for-advanced-stage-thoracic-esophageal-squamous-cell-carcinoma
#17
Chia-Lun Chang, Hsieh-Chih Tsai, Wei-Cheng Lin, Jer-Hwa Chang, Han-Lin Hsu, Jyh-Ming Chow, Kevin Sheng-Po Yuan, Alexander T H Wu, Szu-Yuan Wu
PURPOSE: No studies have investigated the effects of irradiation-dose escalation intensity-modulated radiotherapy (IMRT)-based concurrent chemoradiotherapy (CCRT) in patients with thoracic esophageal squamous cell carcinoma (TESCC). PATIENTS AND METHODS: We analyzed data from patients with TESCC who were enrolled in the Taiwan Cancer Registry database. To compare treatment outcomes, the patients were categorized into two groups according to their radiotherapy doses: group 1, who received CCRT<60Gy with IMRT, and group 2, who received CCRT≥60Gy with IMRT...
October 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28922727/the-relevance-of-gastric-cancer-biomarkers-in-prognosis-and-pre-and-post-chemotherapy-in-clinical-practice
#18
REVIEW
Muhammad Abbas, Murad Habib, Muhammad Naveed, Kumaragurubaran Karthik, Kuldeep Dhama, Meiqi Shi, Chen Dingding
Gastric cancer (GC) is one among the major cancer types, causing human deaths and present noticeable heterogeneity. The incidences and mortality rates are higher in males in comparison to females with a male to female ratio of 2.3:1. A lot of studies have revealed out the molecular basis, pathogenesis, invasion and metastasis related findings of gastric stomach cancer. Present review encompasses the salient information on various biomarkers for the early diagnosis, treatment and prognosis of gastric cancer elaborate the clinical importance of serum tumor markers in patients with this cancer as well as checking the growths, together with epigenetic changes and genetic polymorphisms...
September 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28903383/association-between-abo-blood-types-and-sporadic-pancreatic-neuroendocrine-tumors-in-the-chinese-han-population
#19
Qiwen Ben, Jun Liu, Weiyi Wang, Fang Guo, Weiyan Yao, Jie Zhong, Yaozong Yuan
BACKGROUND: Although the relationship between non-O blood types and the risk of exocrine pancreatic cancer has been demonstrated, the association between ABO blood types and sporadic pancreatic neuroendocrine tumor (PNET) has not been reported thus far. METHODS: This hospital-based, case-control study included 387 patients with PNET and 542 age- and sex-matched controls. Unconditional multivariable logistic regression analysis was performed to estimate the adjusted odds ratios (AORs) and 95% confidence intervals (CIs)...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28895416/associations-of-the-variable-number-of-tandem-repeats-polymorphism-in-the-smyd3-gene-with-risk-and-prognosis-of-esophageal-cancer-a-case-control-study
#20
H F Wang, Y L Qu, L Y Ma, Y Tang
The aim of this study was to explore the associations between the variable number of tandem repeats (VNTR) polymorphism in the SMYD3 gene and the risk and prognosis of esophageal cancer (EC). A total of 546 EC patients (case group) and 580 healthy individuals (control group) were recruited for this study. Direct DNA sequencing of polymerase chain reaction (PCR) products was applied to detect the SMYD3 VNTR genotypes. A non-conditional logistic regression model was used to analyze the associations between different VNTR genotypes and clinicopathological features with the risk of EC...
September 12, 2017: Neoplasma
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