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https://www.readbyqxmd.com/read/29199703/metastatic-nonsmall-cell-lung-cancer-in-south-india-a-regional-demographic-study
#1
K C Lakshmaiah, M P Kamath, K G Babu, U Amirtham, D Loknatha, A S Komaranchath
BACKGROUND: Nonsmall cell lung cancer (NSCLC) has varying epidemiological patterns in different countries and also in different regions of each country. In a country with a high prevalence of lung cancer such as India, regional variations in demography exist. AIM: A study of unique demographic trends of metastatic NSCLC patients presenting to our regional cancer center. MATERIALS AND METHODS: We did a retrospective analysis of histologically confirmed metastatic NSCLC patients who presented to our Department of Medical Oncology between August 2012 and July 2014...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29177066/non-acid-gastro-oesophageal-reflux-is-associated-with-squamous-cell-carcinoma-of-the-oesophagus
#2
Mpho Kgomo, Taole R Mokoena, James A Ker
Introduction: Squamous cell carcinoma of the oesophagus is a common cancer among South Africans. Due to the absence of effective screening and surveillance programme for early detection and late presentation, squamous cell carcinoma of the oesophagus is usually diagnosed at an advanced stage or when metastasis has already occurred. The 5-year survival is often quoted at 5%-10%, which is poor. Objectives: To determine the association between oesophageal squamous cell carcinoma (OSCC) and non-acid gastro-oesophageal reflux disease...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29176296/periostin-expression-in-non-small-cell-lung-cancer-clinical-significance
#3
Daigo Murakami, Shinzo Takamori, Akihiko Kawahara, Masahiro Mitsuoka, Masaki Kashihara, Koichi Yoshiyama, Ryoichi Matsumoto, Shintaro Yokoyama, Kiminori Fujimoto, Atsushi Kawaguchi, Kenji Izuhara, Yoshito Akagi
Periostin is an extracellular matrix N-glycoprotein that is a major constituent of the desmoplastic stroma around solid tumors. Periostin promotes tumor invasion and metastasis via epithelial-mesenchymal transition. The aims of this study were to evaluate periostin expression immunohistochemically and quantitatively in patients with non-small cell lung cancer (NSCLC) and to assess any associations with clinical features and prognosis. A total of 184 specimens of NSCLC tissue were investigated, including 134 adenocarcinomas, 39 squamous cell carcinomas, and 11 other histologic subtypes...
November 27, 2017: Kurume Medical Journal
https://www.readbyqxmd.com/read/29175386/impact-of-clinicopathologic-features-on-the-efficacy-of-pd-1-pd-l1-inhibitors-in-patients-with-previously-treated-non-small-cell-lung-cancer
#4
Tao Jiang, Hongcheng Liu, Meng Qiao, Xuefei Li, Chao Zhao, Chunxia Su, Shengxiang Ren, Caicun Zhou
BACKGROUND: The current study aimed to comprehensively investigate the impact of various clinicopathologic features on the efficacy of programmed cell death-1 (PD-1) and ligand (PD-L1) inhibitors in patients with previously treated non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Randomized controlled trials that compared PD-1/PD-L1-inhibitor monotherapy with chemotherapy or placebo in patients with previously treated NSCLC were included. RESULTS: Five trials were included (n = 3025)...
November 9, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29151950/mcms-expression-in-lung-cancer-implication-of-prognostic-significance
#5
Yi-Zhen Liu, Bo-Shi Wang, Yan-Yi Jiang, Jian Cao, Jia-Jie Hao, Yu Zhang, Xin Xu, Yan Cai, Ming-Rong Wang
Minichromosome Maintenance (MCM) proteins play essential roles in various cancers. We previously reported that MCM7 could be a prognostic biomarker in non-small cell lung cancer (NSCLC). The purpose of current study is to explore roles of other MCM proteins in NSCLC and their correlation with clinico-pathologic parameters of NSCLC patients. We evaluated the expression of MCM2, MCM5 and MCM6 immunohistochemically in 571 primary NSCLC samples. High expression of MCM2, MCM5 and MCM6 was detected in 42.2%, 38.3% and 52...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29142805/role-of-adjuvant-treatment-in-sinonasal-mucosal-melanoma
#6
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Michael E Kupferman, Shirley Y Su, Shaan M Raza, Franco DeMonte, Ehab Y Hanna
Purpose  Sinonasal mucosal melanoma (SNMM) is a locally aggressive tumor. This study aimed to define the role of adjuvant treatment and its association with survival outcomes of SNMM. Methods  This retrospective study investigated 152 patients with SNMM treated between 1991 and 2016 in MD Anderson Cancer Center. Patients were divided into the following treatment groups: surgery alone, surgery with postoperative radiotherapy (PORT), surgery with postoperative chemoradiation (POCRT), and induction chemotherapy followed by surgery and PORT...
December 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29142753/long-term-survival-in-a-patient-with-metastatic-squamous-cell-lung-carcinoma-a-case-report
#7
Emiddio Barletta, Piera Federico, Vincenza Tinessa, Domenico Germano, Lucia Cannella, Teresa Pironti, Bruno Daniele
Non-small-cell lung cancer (NSCLC) is the most common malignancy in industrialized countries, with a 5-year survival rate of only ~15%, as the majority of the patients have advanced-stage disease at diagnosis and the treatment options are limited. Squamous cell carcinoma the second most frequent type of NSCLC and is closely associated with cigarette smoking. We herein present the case of a 72-year-old male smoker, diagnosed with stage IV squamous cell lung carcinoma, with a solitary brain metastasis. After the diagnosis, stereotactic radiotherapy was performed on the brain metastasis...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29138815/curcumin-reverses-tobacco-smoke%C3%A2-induced-epithelial%C3%A2-mesenchymal-transition-by-suppressing-the-mapk-pathway-in-the-lungs-of-mice
#8
Zhaofeng Liang, Rui Wu, Wei Xie, Mingming Zhu, Chunfeng Xie, Xiaoting Li, Jianyun Zhu, Weiwei Zhu, Jieshu Wu, Shanshan Geng, Wenrong Xu, Caiyun Zhong, Hongyu Han
Tobacco smoke is a major risk factor for lung cancer. Epithelial‑mesenchymal transition (EMT) is decisive in cancer invasion and metastasis, and therefore promotes cancer progression. Mitogen‑activated protein kinase (MAPK) pathways are implicated in various aspects of cancer development and progression, including the EMT process. The chemopreventive effect of curcumin on carcinogenesis has been reported in vivo and in vitro. The present study investigated tobacco smoke‑induced alterations in the MAPK/activator protein‑1 (AP‑1) pathways, and pulmonary EMT changes in the lungs of mice, and further observed the chemopreventive effect of curcumin...
November 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29136605/scalp-metastasis-as-an-initial-presentation-of-lung-adenocarcinoma-a-case-report-and-literature-review
#9
Veena Gupta, Namita Bhutani, Nisha Marwah, Rajeev Sen
INTRODUCTION: Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence of 0.22%-10% among various series. However, the presence of cutaneous metastasis as the first sign of a clinically silent visceral cancer is exceedingly rare. PRESENTATION OF CASE: We describe here a case of an asymptomatic male patient who presented with a solitary scalp metastasis as the initial manifestation of an underlying lung cancer...
November 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29128478/protein-overexpression-and-gene-amplification-of-cellular-mesenchymal-epithelial-transition-factor-is-associated-with-poor-prognosis-in-micropapillary-predominant-subtype-pulmonary-adenocarcinoma
#10
Jing Zhang, Jian Sun, Zhiwen Zhang, Xiaolong Liang, Yufeng Luo, Shafei Wu, Zhiyong Liang
Micropapillary predominant subtype pulmonary adenocarcinoma (MPPAC) is a subtype of lung cancer with poor prognosis. Cellular mesenchymal-epithelial transition factor (c-MET) is a promising pharmaceutic target found to be associated with the survival of patients with pulmonary adenocarcinoma (PAC). In this study, we aimed to analyze c-MET protein overexpression and gene amplification in MPPAC samples and to elucidate their relationship with the clinicopathological characteristics of the patients. c-MET protein expression was examined by immunohistochemical analyses, and gene amplification was detected by fluorescence in situ hybridization(FISH)...
November 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/29127022/genetic-and-immune-profiles-of-solid-predominant-lung-adenocarcinoma-reveal-potential-immunotherapeutic-strategies
#11
Zhong-Yi Dong, Chao Zhang, Yu-Fa Li, Jian Su, Zhi Xie, Si-Yang Liu, Li-Xu Yan, Zhi-Hong Chen, Xue-Ning Yang, Jun-Tao Lin, Hai-Yan Tu, Jin-Ji Yang, Qing Zhou, Yue-Li Sun, Wen-Zhao Zhong, Yi-Long Wu
BACKGROUND: Subtype classification of lung adenocarcinoma (LUAD) divides different survivals and therapeutic vulnerabilities, while the underlying molecular mechanism is little to be known. This study sought to determine the genetic and immune profiles of histologic subtypes and identify the evidence for adjuvant immunotherapy. PATIENTS AND METHODS: We performed an integrated analysis on multidimensional data from a discovery set including cohorts of The Cancer Genome Atlas (TCGA) and the Broad set from the LUAD public database, and a validation set from the Guangdong Lung Cancer Institute (GLCI)...
November 7, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29121049/haplotype-cgc-from-xpd-hogg1-and-itga2-polymorphisms-increases-the-risk-of-nasopharyngeal-carcinoma-in-malaysia
#12
Eng-Zhuan Ban, Munn-Sann Lye, Pei Pei Chong, Yoke-Yeow Yap, Siew Ying Crystale Lim, Hejar Abdul Rahman
BACKGROUND: 8-oxoG, a common DNA lesion resulting from reactive oxygen species (ROS), has been shown to be associated with cancer initiation. hOGG1 DNA glycosylase is the primary enzyme responsible for excision of 8-oxoG through base excision repair (BER). Integrins are members of a family of cell surface receptors that mediate the cell-cell and extracellular matrix (ECM) interactions. Integrins are involved in almost every aspect of carcinogenesis, from cell differentiation, cell proliferation, metastasis to angiogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/29113190/predictors-of-egfr-mutation-and-factors-associated-with-clinical-tumor-stage-at-diagnosis-experience-of-the-insight-study-in-poland
#13
Rodryg Ramlau, Paweł Krawczyk, Rafał Dziadziuszko, Izabela Chmielewska, Janusz Milanowski, Włodzimierz Olszewski, Katarzyna Stencel, Katarzyna Ramlau-Piątek, Agnieszka Segiet, Michał Skroński, Jacek Grudny, Joanna Chorostowska-Wynimko
Targeted therapy of non-small cell lung cancer (NSCLC) patients with mutations in the epidermal growth factor receptor (EGFR) gene has been associated with improved prognosis. However, there is a shortage on data from real-world clinical practice in management of EGFR-positive NSCLC patients in Poland. The present study retrospectively analyzed data from the INSIGHT study to evaluate the incidence and clinical management of EGFR-positive NSCLC in Poland. The authors additionally aimed to identify predictors of the EGFR mutation and factors associated with clinical stage of the tumor at diagnosis...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29108386/single-nucleotide-polymorphisms-in-mlh1-predict-poor-prognosis-of-hepatocellular-carcinoma-in-a-chinese-population
#14
Xiaonian Zhu, Wei Liu, Xiaoqiang Qiu, Zhigang Wang, Chao Tan, Chunhua Bei, Linyuan Qin, Yuan Ren, Shengkui Tan
Hepatocellular carcinoma (HCC) is a malignant cancer causing deleterious health effect worldwide, especially in China. So far clinical cure rate and long-term survival rate of HCC remains low. Most HCC patients after cancer resection have recurrence or metastasis within 5 years. This study aims to explore the genetic association of mutL homolog 1 (MLH1) polymorphisms with HCC risk and prognosis. Four candidate MLH1 polymorphisms, rs1800734, rs10849, rs3774343 and rs1540354 were studied from a hospital-based case-control study including 1,036 cases (HCC patients) and 1,036 controls (non-HCC patients) in Guangxi, China...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107665/eps8-expression-is-significantly-lower-in-p16-head-and-neck-squamous-cell-carcinomas-hnscc-compared-to-p16-hnscc
#15
Elham Nasri, Lisa B Wiesen, Jacquelyn A Knapik, Kristianna M Fredenburg
In vitro head and neck cancer studies have demonstrated that epidermal growth factor receptor kinase substrate 8 (Eps8) overexpression contributes to squamous carcinogenesis. Oral squamous cell carcinoma studies have correlated Eps8 expression with metastatic disease and poor prognosis. Head and neck squamous cell carcinoma (HNSCC) studies comparing its expression by anatomic site or in in vivo regional metastases have not been performed. In this study, we compared Eps8 expression in HNSCCs arising in the oral cavity (OCSCC) and oropharynx (OPSCC) along with their corresponding regional lymph nodes (LNs) metastases...
October 28, 2017: Human Pathology
https://www.readbyqxmd.com/read/29103755/a-failure-type-specific-risk-prediction-tool-for-selection-of-head-and-neck-cancer-patients-for-experimental-treatments
#16
Katrin Håkansson, Jacob H Rasmussen, Gregers B Rasmussen, Jeppe Friborg, Thomas A Gerds, Barbara Malene Fischer, Flemming L Andersen, Søren M Bentzen, Lena Specht, Ivan R Vogelius
OBJECTIVES: The objective of this work was to develop a tool for decision support, providing simultaneous predictions of the risk of loco-regional failure (LRF) and distant metastasis (DM) after definitive treatment for head-and-neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Retrospective data for 560HNSCC patients were used to generate a multi-endpoint model, combining three cause-specific Cox models (LRF, DM and death with no evidence of disease (death NED))...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29061213/-clinical-and-prognosic-anylasis-of-30-cases-with-double-primary-lung-cancer
#17
Ziqi Wang, Jingjing Hou, Huijuan Wang, Guowei Zhang, Zhiyong Ma
BACKGROUND: Multiple primary lung cancer (MPLC) represents a rare variety of pulmonary malignant tumor while mainly consist of double primary lung cancer (DPLC), but the development of diagnostic techniques promotes the rate diagnosis of it in recent years. Here we summarize and anylasis the data of 30 cases with DPLC in expectation of improving congnitive of MPLC. METHODS: We retrospectly studied 30 MPLC patients who diagnosed from January 2010 to December 2015 in Affiliated Cancer Hospital of Zhengzhou University...
October 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29057536/the-combination-of-plasma-fibrinogen-and-neutrophil-lymphocyte-ratio-f-nlr-is-a-predictive-factor-in-patients-with-resectable-non-small-cell-lung-cancer
#18
Haiyan Wang, Jin Zhao, Mingyun Zhang, Lijie Han, Ming Wang, Li Xingde
BACKGROUND: The prognostic value of inflammation indexes in non small cell lung cancer (NSCLC) was not established. Therefore, we assessed the clinical applicability of the F-NLR score, which is based on fibrinogen (F) and the neutrophil-lymphocyte ratio (NLR), and the glasgow prognostic score (GPS) to predict the prognoses of NSCLC patients. METHODS: We retrospectively identified 515 patients with stage I/II/IIIA who underwent surgery at our institution, and evaluated their preoperative serum levels of CRP, albumin, fibrinogen, neutrophil count and the lymphocyte count...
October 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29037837/the-correlation-between-xiap-gene-polymorphisms-and-esophageal-squamous-cell-carcinoma-susceptibility-and-prognosis-in-a-chinese-population
#19
Hai Peng, Li-Guo Wang, Xue-Zhi Wang, Ai-Jun Liu
OBJECTIVE: This study aims to explore the correlation between X-linked inhibitor of apoptosis protein (XIAP) gene polymorphisms (rs8371 and rs9856) with the susceptibility and prognosis of esophageal squamous cell carcinoma (ESCC), providing a potential treatment for ESCC. METHOD: A total of 170 ESCC patients (case group) and 191 healthy people (control group) were enrolled in our study. Genotyping was conducted on the basis of the ligase detection reaction (LDR)...
October 9, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29029446/a-potential-prognostic-biomarker-spc24-promotes-tumorigenesis-and-metastasis-in-lung-cancer
#20
Juan Zhou, Yang Yu, Yunfeng Pei, Chunping Cao, Chen Ding, Duping Wang, Li Sun, Guoping Niu
RESULTS: SPC24 is over-expressed in clinical lung adenocarcinoma samples, and high level of SPC24 is associated with advanced stages of lung tumors. Knocking down SPC24 repressed cell growth and promoted apoptosis. SPC24 deficiency reduced cancer cell migration as well. E-cadherin, one of the epithelial-mesenchymal transition markers, was up-regulated in the knockdown cells, along with down-regulation of N-cadherin and Vimentin. Oncomine expression analyses further confirmed that high level of SPC24 is associated with tumors from smokers, recurrent patients, or patients with shorter survivals...
September 12, 2017: Oncotarget
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