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Soil Pathology

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https://www.readbyqxmd.com/read/27763256/target-of-rapamycin-tor-regulates-growth-in-response-to-nutritional-signals
#1
Ronit Weisman
All organisms can respond to the availability of nutrients by regulating their metabolism, growth, and cell division. Central to the regulation of growth in response to nutrient availability is the target of rapamycin (TOR) signaling that is composed of two structurally distinct complexes: TOR complex 1 (TORC1) and TOR complex 2 (TORC2). The TOR genes were first identified in yeast as target of rapamycin, a natural product of a soil bacterium, which proved beneficial as an immunosuppressive and anticancer drug and is currently being tested for a handful of other pathological conditions including diabetes, neurodegeneration, and age-related diseases...
October 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27708245/chronic-low-dose-rate-ionising-radiation-affects-the-hippocampal-phosphoproteome-in-the-apoe-alzheimer-s-mouse-model
#2
Stefan J Kempf, Dirk Janik, Zarko Barjaktarovic, Ignacia Braga-Tanaka Iii, Satoshi Tanaka, Frauke Neff, Anna Saran, Martin R Larsen, Soile Tapio
Accruing data indicate that radiation-induced consequences resemble pathologies of neurodegenerative diseases such as Alzheimer´s. The aim of this study was to elucidate the effect on hippocampus of chronic low-dose-rate radiation exposure (1 mGy/day or 20 mGy/day) given over 300 days with cumulative doses of 0.3 Gy and 6.0 Gy, respectively. ApoE deficient mutant C57Bl/6 mouse was used as an Alzheimer´s model. Using mass spectrometry, a marked alteration in the phosphoproteome was found at both dose rates...
September 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27680599/application-of-anchoring-stitch-prevents-rectal-prolapse-in-laparoscopic-assisted-anorectal-pullthrough
#3
Jessie L Leung, Patrick Hy Chung, Paul Kh Tam, Kenneth Ky Wong
BACKGROUND: Rectal prolapse has been reported after laparoscopic assisted anorectal pullthrough in children with anorectal malformation. We report our clinical outcome and study the application of an anchoring stitch to tack the rectum to the presacral fascia and the occurrence of rectal prolapse. MATERIAL AND METHODS: A retrospective review of all children who had undergone laparoscopic assisted anorectal pullthrough for anorectal malformation from 2000 to 2015 was performed...
September 17, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27541828/permeability-and-viability-of-baylisascaris-procyonis-eggs-in-southern-texas-soils
#4
Jacob L Ogdee, Scott E Henke, David B Wester, Alan M Fedynich
Baylisascaris procyonis is a nematode whose definitive host is the raccoon (Procyon lotor). Adult parasites are not particularly pathogenic to raccoons; however, larvae in intermediate hosts can cause visceral, ocular, and neural larva migrans. Humans serve as dead-end hosts and pathological responses are similar as those found in infected intermediate hosts. Infected raccoons expose intermediate hosts through their feces, which can contain millions of B. procyonis eggs. Our objective was to determine how the quantity and viability of B...
August 19, 2016: Journal of Parasitology
https://www.readbyqxmd.com/read/27422929/pathology-and-biology-of-radiation-induced-cardiac-disease
#5
Soile Tapio
Heart disease is the leading global cause of death. The risk for this disease is significantly increased in populations exposed to ionizing radiation, but the mechanisms are not fully elucidated yet. This review aims to gather and discuss the latest data about pathological and biological consequences in the radiation-exposed heart in a comprehensive manner. A better understanding of the molecular and cellular mechanisms underlying radiation-induced damage in heart tissue and cardiac vasculature will provide novel targets for therapeutic interventions...
July 15, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27372296/anorectal-malformations-associated-spinal-cord-anomalies
#6
Giorgia Totonelli, Francesco Morini, Vincenzo Davide Catania, Paolo Maria Schingo, Giovanni Mosiello, Paolo Palma, Barbara Daniela Iacobelli, Pietro Bagolan
PURPOSE: The present study aims to identify clinical and pathological factors that can predict the risk of spinal cord anomalies (SCA) in patients with anorectal malformations (ARM), the need for neurosurgery, and to define the impact of SCA on the outcome of patients with ARM. METHODS: A 16-year retrospective analysis of all patients treated at a single tertiary children's Hospital with diagnosis of ARM. Data were collected to assess the impact of defined clinical characteristics on prevalence of SCA (detected at MRI)...
August 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27352439/correlations-between-the-autolytic-changes-and-postmortem-interval-in-refrigerated-cadavers
#7
Ela Andra Cocariu, V Mageriu, Florica Stăniceanu, Alexandra Bastian, C Socoliuc, Sabina Zurac
INTRODUCTION: In forensic pathology the autolytic process has been observed and documented in order to determine the postmortem interval as accurately as possible. The observation and experiments have been carried out on cadavers exposed to environmental conditions - heat, humidity, air currents, soil, water. METHODS: For this study hematoxylin and eosin (HE) stained sections of organ samples from 30 autopsied bodies were examined under the microscope. Modifications of tissue and cell structures were noted in correlation with the bodies' time spent in the Morgue's mortuary refrigerator until the autopsy was performed, which varied between 24 hours and 22 days...
April 2016: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/27174690/a-preliminary-study-on-health-effects-in-villagers-exposed-to-mercury-in-a-small-scale-artisanal-gold-mining-area-in-indonesia
#8
Stephan Bose-O'Reilly, Rudolf Schierl, Dennis Nowak, Uwe Siebert, Jossep Frederick William, Fradico Teorgi Owi, Yuyun Ismawati Ir
Cisitu is a small-scale gold mining village in Indonesia. Mercury (Hg) is used to extract gold from ore, heavily polluting air, soil, fish and rice paddy fields with Hg. Rice in Cisitu is burdened with mercury. The main staple food of the inhabitants of Cisitu is this polluted rice. Villagers were concerned that the severe diseases they observed in the community might be related to their mining activities, including high mercury exposure. Case report of the medical examinations and the mercury levels in urine and hair of 18 people with neurological symptoms...
August 2016: Environmental Research
https://www.readbyqxmd.com/read/27098509/sarcopenia-frailty-and-diabetes-in-older-adults
#9
REVIEW
Hak Chul Jang
Populations are aging and the prevalence of diabetes mellitus is increasing tremendously. The number of older people with diabetes is increasing unexpectedly. Aging and diabetes are both risk factors for functional disability. Thus, increasing numbers of frail or disabled older patients with diabetes will increase both direct and indirect health-related costs. Diabetes has been reported as an important risk factor of developing physical disability in older adults. Older people with diabetes have lower muscle mass and weaker muscle strength...
June 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/26944446/autochthonous-cutaneous-larva-migrans-infection-in-guip%C3%A3%C2%BAzcoa
#10
A Panés-Rodríguez, L Piera-Tuneu, A López-Pestaña, N Ormaetxea-Pérez, P Gutiérrez-Támara, S Ibarbia-Oruezabal, A Tuneu-Valls
INTRODUCTION: Cutaneous larva migrans (LM) infection forms a serpiginous eruption caused by the migration of nematode helminths through the epidermis. The parasites are acquired when the skin comes into contact with soil contaminated by the feces of infected animals. Until now, infections have been believed to be imported from tropical and subtropical regions. Our aim was to study cases of cutaneous LM diagnosed in residents of the Spanish province of Guipúzcoa who had not recently traveled to such regions...
June 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/26904749/inhibition-of-quorum-sensing-controlled-virulence-factors-and-biofilm-formation-in-pseudomonas-aeruginosa-by-culture-extract-from-novel-bacterial-species-of-paenibacillus-using-a-rat-model-of-chronic-lung-infection
#11
Saad Musbah Alasil, Rahmat Omar, Salmah Ismail, Mohd Yasim Yusof
Quorum sensing (QS) is a key regulator of virulence factors and biofilm formation in Gram-negative bacteria such as Pseudomonas aeruginosa. Microorganisms that inhabit soil are of strategic importance in the discovery of compounds with anti-QS properties. The objective of the study was to test the culture extract of a taxonomically novel species of Paenibacillus strain 139SI for its inhibitory effects on the QS-controlled virulence factors and biofilm formation of Pseudomonas aeruginosa both in vitro and in vivo...
2015: International Journal of Bacteriology
https://www.readbyqxmd.com/read/26868644/cadmium-accumulation-and-pathological-alterations-in-the-midgut-gland-of-terrestrial-snail-helix-pomatia-l-from-a-zinc-smelter-area-role-of-soil-ph
#12
Tadeusz Włostowski, Paweł Kozłowski, Barbara Łaszkiewicz-Tiszczenko, Ewa Oleńska
The purpose of this study was to determine whether cadmium (Cd) accumulation and toxicity in the midgut gland of Helix pomatia snails living in a Cd-contaminated area were related to soil pH. Toxic responses in the midgut gland (i.e., increased vacuolization and lipid peroxidation) occurred in H. pomatia snails exhibiting the highest Cd levels in the gland (265-274 µg/g dry wt) and living on acidic soil (pH 5.3-5.5), while no toxicity was observed in snails accumulating less Cd (90 µg/g) and ranging on neutral soil (pH 7...
April 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/26863445/microbial-communities-in-globodera-pallida-females-raised-in-potato-monoculture-soil
#13
Caroline Eberlein, Holger Heuer, Stefan Vidal, Andreas Westphal
Globodera spp. are under strict quarantine in many countries. Suppressiveness to cyst nematodes can evolve under monoculture of susceptible hosts. Females developing in potato monoculture soil infested with G. pallida populations Chavornay or Delmsen were examined for inherent microbial communities. In the greenhouse, nonheated and heat-treated (134°C for 10 min) portions of this soil were placed in root observation chambers, planted with Solanum tuberosum 'Selma', and inoculated with G. pallida Pa3 Chavornay...
June 2016: Phytopathology
https://www.readbyqxmd.com/read/26856161/-the-features-of-prevalence-of-skin-disease-as-an-index-of-ecologically-related-morbidity-of-population-in-bioclimatic-zones-of-primorye-krai
#14
M V Yarygina, P F Kiku, T V Gorborukova
There are presented results of the socio-hygienic analysis of ecologically related skin pathology ofthe population of Primorsky Krai. The aim of the work is to establish the patterns of distribution of ecologically related skin diseases in various ecological bioclimatic zones of Primorsky Krai. There was performed an analysis of skin diseases ofform 12 according to ICD-10 main demographic groups (children, adolescents and adults) of the population of Primorsky Krai, residing in various bioclimatic zones of Krai with different levels of environmental stringency in rural and urban areas for the period of 2000-2013...
2015: Gigiena i Sanitariia
https://www.readbyqxmd.com/read/26842961/schistosoma-haematobium-and-soil-transmitted-helminths-in-tana-delta-district-of-kenya-infection-and-morbidity-patterns-in-primary-schoolchildren-from-two-isolated-villages
#15
Kariuki H Njaanake, Birgitte J Vennervald, Paul E Simonsen, Henry Madsen, Dunstan A Mukoko, Gachuhi Kimani, Walter G Jaoko, Benson B Estambale
BACKGROUND: Schistosomes and soil-transmitted helminths (STH) (hookworm, Trichuris trichiura and Ascaris lumbricoides) are widely distributed in developing countries where they infect over 230 million and 1.5 billion people, respectively. The parasites are frequently co-endemic and many individuals are co-infected with two or more of the species, but information on how the parasites interact in co-infected individuals is scarce. The present study assessed Schistosoma haematobium and STH infection and morbidity patterns among school children in a hyper-endemic focus in the Tana River delta of coastal Kenya...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/26829122/multifactorial-theory-applied-to-the-neurotoxicity-of-paraquat-and-paraquat-induced-mechanisms-of-developing-parkinson-s-disease
#16
Xiao-Feng Zhang, Mark Thompson, Yi-Hua Xu
Laboratory studies involving repeated exposure to paraquat (PQ) in different animal models can induce many of the pathological features of Parkinson's disease (PD), such as the loss of dopaminergic neurons in the nigrostriatal dopamine system. Epidemiological studies identify an increased risk of developing PD in human populations living in areas where PQ exposure is likely to occur and among workers lacking appropriate protective equipment. The mechanisms involved in developing PD may not be due to any single cause, but rather a multifactorial situation may exist where PQ exposure may cause PD in some circumstances...
May 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/26826229/airborne-and-grain-dust-fungal-community-compositions-are-shaped-regionally-by-plant-genotypes-and-farming-practices
#17
Loïc Pellissier, Anne Oppliger, Alexandre H Hirzel, Dessislava Savova-Bianchi, Guilain Mbayo, Fabio Mascher, Stefan Kellenberger, Hélène Niculita-Hirzel
Chronic exposure to airborne fungi has been associated with different respiratory symptoms and pathologies in occupational populations, such as grain workers. However, the homogeneity in the fungal species composition of these bioaerosols on a large geographical scale and the different drivers that shape these fungal communities remain unclear. In this study, the diversity of fungi in grain dust and in the aerosols released during harvesting was determined across 96 sites at a geographical scale of 560 km(2) along an elevation gradient of 500 m by tag-encoded 454 pyrosequencing of the internal transcribed spacer (ITS) sequences...
April 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/26825985/5-years-after-an-ace-what-happens-then
#18
Clara Chong, Neil Featherstone, Shazia Sharif, Abraham Cherian, Peter Cuckow, Imran Mushtaq, Paolo De Coppi, Kate Cross, Joseph Curry
PURPOSE: Antegrade continence enema (ACE) revolutionised the lives of children with chronic constipation and soiling. Parents often ask how long the ACE will be required. We looked at our patients 5 years after ACE formation to answer the question. METHODS: We reviewed clinical notes of all patients undergoing ACE procedure during January 1990 to December 2010. Only patients with >5 years follow-up were included. Data are given as median (range). RESULTS: 133 patients were included with >5 years of follow-up...
April 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/26825607/disseminated-and-circulating-tumor-cells-in-bone-marrow-and-blood-of-breast-cancer-patients-properties-enrichment-and-potential-targets
#19
REVIEW
C Schindlbeck, U Andergassen, J Jueckstock, B Rack, W Janni, U Jeschke
INTRODUCTION: From the early days of pathology back in the nineteenth century until now, there has been an ongoing search for the missing link between solid tumors such as breast cancer and distant metastases, which sometimes occur many years after removal of the primary tumor. The "seed and soil" theory hypothesizes the early dissemination of occult tumor cells into blood or bone marrow, which can persist in a dormant state for a long time and then become precursors of metastases in distant organs which offer appropriate conditions...
September 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/26706959/pantoea-agglomerans-a-marvelous-bacterium-of-evil-and-good-part-i-deleterious-effects-dust-borne-endotoxins-and-allergens-focus-on-cotton-dust
#20
REVIEW
Jacek Dutkiewicz, Barbara Mackiewicz, Marta Kinga Lemieszek, Marcin Golec, Janusz Milanowski
The ubiquitous Gram-negative bacterium Pantoea agglomerans (synonyms: Enterobacter agglomerans, Erwinia herbicola) is known both as an epiphytic microbe developing on the surface of plants and as an endophytic organism living inside the plants. The bacterium occurs also abundantly in plant and animal products, in the body of arthropods and other animals, in water, soil, dust and air, and occasionally in humans. From the human viewpoint, the role of this organism is ambiguous, both deleterious and beneficial: on one side it causes disorders in people exposed to inhalation of organic dusts and diseases of crops, and on the other side it produces substances effective in the treatment of cancer and other diseases of humans and animals, suppresses the development of various plant pathogens, promotes plant growth, and appears as a potentially efficient biofertilizer and bioremediator...
2015: Annals of Agricultural and Environmental Medicine: AAEM
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