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Ruth Clark

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https://www.readbyqxmd.com/read/29734962/living-well-with-dementia-a-systematic-review-and-correlational-meta-analysis-of-factors-associated-with-quality-of-life-well-being-and-life-satisfaction-in-people-with-dementia
#1
Anthony Martyr, Sharon M Nelis, Catherine Quinn, Yu-Tzu Wu, Ruth A Lamont, Catherine Henderson, Rachel Clarke, John V Hindle, Jeanette M Thom, Ian Rees Jones, Robin G Morris, Jennifer M Rusted, Christina R Victor, Linda Clare
Current policy emphasises the importance of 'living well' with dementia, but there has been no comprehensive synthesis of the factors related to quality of life (QoL), subjective well-being or life satisfaction in people with dementia. We examined the available evidence in a systematic review and meta-analysis. We searched electronic databases until 7 January 2016 for observational studies investigating factors associated with QoL, well-being and life satisfaction in people with dementia. Articles had to provide quantitative data and include ⩾75% people with dementia of any type or severity...
May 8, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29724445/advancing-continuous-predictive-analytics-monitoring-moving-from-implementation-to-clinical-action-in-a-learning-health-system
#2
REVIEW
Jessica Keim-Malpass, Rebecca R Kitzmiller, Angela Skeeles-Worley, Curt Lindberg, Matthew T Clark, Robert Tai, James Forrest Calland, Kevin Sullivan, J Randall Moorman, Ruth A Anderson
In the intensive care unit, clinicians monitor a diverse array of data inputs to detect early signs of impending clinical demise or improvement. Continuous predictive analytics monitoring synthesizes data from a variety of inputs into a risk estimate that clinicians can observe in a streaming environment. For this to be useful, clinicians must engage with the data in a way that makes sense for their clinical workflow in the context of a learning health system (LHS). This article describes the processes needed to evoke clinical action after initiation of continuous predictive analytics monitoring in an LHS...
June 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/29718745/use-of-whole-genome-sequencing-in-surveillance-of-drug-resistant-tuberculosis
#3
Ruth McNerney, Matteo Zignol, Taane G Clark
The threat of resistance to anti-tuberculosis drugs is of global concern. Current efforts to monitor resistance rely on phenotypic testing where cultured bacteria are exposed to critical concentrations of the drugs. Capacity for such testing is low in TB endemic countries. Drug resistance is caused by mutations in the Mycobacterium tuberculosis genome and whole genome sequencing to detect these mutations offers an alternative means of assessing resistance. Areas covered: The challenges of assessing TB drug resistance are discussed...
May 2, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29680586/the-professional-and-personal-debriefing-needs-of-ward-based-nurses-after-involvement-in-a-cardiac-arrest-an-explorative-qualitative-pilot-study
#4
Ruth Clark, Chris McLean
BACKGROUND: Current research demonstrates that debriefing staff post cardiac arrest in clinical practice is rare, with little evidence of effectiveness. OBJECTIVES: The aim of this pilot study was to identify the needs of ward based nurses for debriefing after involvement in a cardiac arrest and to identify any barriers to participating in debriefing. METHODOLOGY: An explorative qualitative study was undertaken with a purposive sample of seven nurses working on acute adult wards in a United Kingdom hospital...
April 18, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29674744/author-correction-genome-wide-analysis-of-multi-and-extensively-drug-resistant-mycobacterium-tuberculosis
#5
Francesc Coll, Jody Phelan, Grant A Hill-Cawthorne, Mridul B Nair, Kim Mallard, Shahjahan Ali, Abdallah M Abdallah, Saad Alghamdi, Mona Alsomali, Abdallah O Ahmed, Stephanie Portelli, Yaa Oppong, Adriana Alves, Theolis Barbosa Bessa, Susana Campino, Maxine Caws, Anirvan Chatterjee, Amelia C Crampin, Keertan Dheda, Nicholas Furnham, Judith R Glynn, Louis Grandjean, Dang Minh Ha, Rumina Hasan, Zahra Hasan, Martin L Hibberd, Moses Joloba, Edward C Jones-López, Tomoshige Matsumoto, Anabela Miranda, David J Moore, Nora Mocillo, Stefan Panaiotov, Julian Parkhill, Carlos Penha, João Perdigão, Isabel Portugal, Zineb Rchiad, Jaime Robledo, Patricia Sheen, Nashwa Talaat Shesha, Frik A Sirgel, Christophe Sola, Erivelton Oliveira Sousa, Elizabeth M Streicher, Paul Van Helden, Miguel Viveiros, Robert M Warren, Ruth McNerney, Arnab Pain, Taane G Clark
In the version of this article initially published, the URL listed for TubercuList was incorrect. The correct URL is https://mycobrowser.epfl.ch/. The error has been corrected in the HTML and PDF versions of the article.
April 19, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29650553/enduring-epigenetic-landmarks-define-the-cancer-microenvironment
#6
Ruth Pidsley, Mitchell G Lawrence, Elena Zotenko, Birunthi Niranjan, Aaron Statham, Jenny Song, Roman M Chabanon, Wenjia Qu, Hong Wang, Michelle Richards, Shalima S Nair, Nicola J Armstrong, Hieu T Nim, Melissa Papargiris, Preetika Balanathan, Hugh French, Timothy Peters, Sam Norden, Andrew Ryan, John Pedersen, James Kench, Roger J Daly, Lisa G Horvath, Phillip Stricker, Mark Frydenberg, Renea A Taylor, Clare Stirzaker, Gail P Risbridger, Susan J Clark
The growth and progression of solid tumors involves dynamic cross-talk between cancer epithelium and the surrounding microenvironment. To date, molecular profiling has largely been restricted to the epithelial component of tumors; therefore, features underpinning the persistent protumorigenic phenotype of the tumor microenvironment are unknown. Using whole-genome bisulfite sequencing, we show for the first time that cancer-associated fibroblasts (CAFs) from localized prostate cancer display remarkably distinct and enduring genome-wide changes in DNA methylation, significantly at enhancers and promoters, compared to nonmalignant prostate fibroblasts (NPFs)...
May 2018: Genome Research
https://www.readbyqxmd.com/read/29630162/fluctuating-lesion-of-the-scalp-after-a-journey-to-the-tropics-a-case-of-furunculoid-myiasis
#7
Sara Geyer, Galina Balakirski, Dennis Tappe, Claudio Cacch, Ruth Knüchel-Clarke, Laurenz Schmit
Fluctuating lesions or furuncles of the scalp occur frequently in dermatological practice. This clinical condition is often caused by gram positive bacteria (e.g. staphylococcal or streptococcal skin infection) or fungal infection (e.g. Kerion celsi). However, a rare diagnosis such as myiasis might be considered, especially if a journey to an endemic area is reported. Herein, we present a case of furunculoid myiasis of the scalp and review the pathogenesis and therapeutic options to treat this condition.
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29607242/genetic-testing-preferences-of-individuals-in-families-with-essential-tremor
#8
Kelly V Naranjo, Jemin Park, Karen P Chen, Nora Hernandez, Lorraine N Clark, Ruth Ottman, Elan D Louis
Background: The search for essential tremor (ET) genes is active, and it is only a matter of time before genetic tests become available. Genetic testing preferences in families have been studied in numerous other neurological disorders but there are no published data about ET. Methods: We surveyed 34 ET probands and their relatives (43 affected, 28 unaffected) enrolled in our Family Study of Essential Tremor to assess their interest in genetic testing. We examined whether clinical factors influenced their interest in testing...
2018: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29559379/clonal-expansion-across-the-seas-as-seen-through-cplp-tb-database-a-joint-effort-in-cataloguing-mycobacterium-tuberculosis-genetic-diversity-in-portuguese-speaking-countries
#9
João Perdigão, Carla Silva, Jaciara Diniz, Catarina Pereira, Diana Machado, Jorge Ramos, Hugo Silva, Fernanda Abilleira, Clarice Brum, Ana J Reis, Maíra Macedo, João L Scaini, Ana B Silva, Leonardo Esteves, Rita Macedo, Fernando Maltez, Sofia Clemente, Elizabeth Coelho, Sofia Viegas, Paulo Rabna, Amabélia Rodrigues, Nuno Taveira, Luísa Jordao, Afrânio Kritski, José Lapa E Silva, Igor Mokrousov, David Couvin, Nalin Rastogi, Isabel Couto, Arnab Pain, Ruth McNerney, Taane G Clark, Andrea von Groll, Elis R Dalla-Costa, Maria Lúcia Rossetti, Pedro E A da Silva, Miguel Viveiros, Isabel Portugal
Tuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. To address this, we have assembled and analysed the largest CPLP M. tuberculosis molecular and drug susceptibility dataset, comprised by a total of 1447 clinical isolates, including 423 multidrug-resistant isolates, from five CPLP countries...
March 17, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29474227/caring-in-the-margins-a-scholarship-of-accompaniment-for-advanced-transcultural-nursing-practice
#10
Ruth C Enestvedt, Kathleen M Clark, Kaija Freborg, Joyce P Miller, Cheryl J Leuning, Deborah K Schuhmacher, Kristin M McHale, Katherine A Baumgartner, Susan L Loushin
Nurses must learn essential skills based in transcultural nursing to address issues of equity and social justice. The development of a model for nursing practice for an urban nurse-led drop-in center for individuals experiencing marginalization provides an opportunity for student nurses to learn transcultural nursing skills that shifts care from acknowledging the need of others to accompanying others on their health journey. The practice model provides the opportunity for undergraduate and graduate nursing students at Augsburg University to de-emphasize tasks and build relationships...
February 22, 2018: ANS. Advances in Nursing Science
https://www.readbyqxmd.com/read/29434571/knowledge-about-essential-tremor-a-study-of-essential-tremor-families
#11
Ashley D Cristal, Karen P Chen, Nora Cristina Hernandez, Pam Factor-Litvak, Lorraine N Clark, Ruth Ottman, Elan D Louis
Background: Essential tremor (ET) is among the most common neurological diseases and it often runs in families. How knowledgeable ET patients and their families are about their disease has been the subject of surprisingly little scholarship. Methods: To fill this gap in knowledge, we administered a comprehensive 32-item survey (i.e., questions about etiology, pathophysiology, symptoms and signs, natural history, and treatments) to 427 participants, including 76 ET probands, 74 affected relatives (AFRs), 238 unaffected relatives, and 39 spouses of unaffected relatives, all of whom were participating in two ET family studies...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29426299/the-delirium-and-population-health-informatics-cohort-study-protocol-ascertaining-the-determinants-and-outcomes-from-delirium-in-a-whole-population
#12
Daniel Davis, Sarah Richardson, Joanne Hornby, Helen Bowden, Katrin Hoffmann, Maryse Weston-Clarke, Fenella Green, Nishi Chaturvedi, Alun Hughes, Diana Kuh, Elizabeth Sampson, Ruth Mizoguchi, Khai Lee Cheah, Melanie Romain, Abhi Sinha, Rodric Jenkin, Carol Brayne, Alasdair MacLullich
BACKGROUND: Delirium affects 25% of older inpatients and is associated with long-term cognitive impairment and future dementia. However, no population studies have systematically ascertained cognitive function before, cognitive deficits during, and cognitive impairment after delirium. Therefore, there is a need to address the following question: does delirium, and its features (including severity, duration, and presumed aetiologies), predict long-term cognitive impairment, independent of cognitive impairment at baseline? METHODS: The Delirium and Population Health Informatics Cohort (DELPHIC) study is an observational population-based cohort study based in the London Borough of Camden...
February 9, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29420958/lipids-lipoproteins-and-metabolites-and-risk-of-myocardial-infarction-and-stroke
#13
Michael V Holmes, Iona Y Millwood, Christiana Kartsonaki, Michael R Hill, Derrick A Bennett, Ruth Boxall, Yu Guo, Xin Xu, Zheng Bian, Ruying Hu, Robin G Walters, Junshi Chen, Mika Ala-Korpela, Sarah Parish, Robert J Clarke, Richard Peto, Rory Collins, Liming Li, Zhengming Chen
BACKGROUND: Blood lipids are established risk factors for myocardial infarction (MI), but uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating metabolites for MI and stroke subtypes. OBJECTIVES: This study sought to investigate the associations of plasma metabolic markers with risks of incident MI, ischemic stroke (IS), and intracerebral hemorrhage (ICH). METHODS: In a nested case-control study (912 MI, 1,146 IS, and 1,138 ICH cases, and 1,466 common control subjects) 30 to 79 years of age in China Kadoorie Biobank, nuclear magnetic resonance spectroscopy measured 225 metabolic markers in baseline plasma samples...
February 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29406910/immunohistochemistry-and-electrophysiological-findings-in-swine-abattoir-workers-with-immune-mediated-polyradiculoneuropathy
#14
Suraj A Muley, Stacy Holzbauer, Brent Clark, James Sejvar, Ruth Lynfield, Gareth Parry, Aaron S DeVries
IMPORTANCE: Workers exposed to aerosolized brain in a swine-processing plant developed immune-mediated polyradiculoneuropathy (IP) possibly triggered by an immune response. OBJECTIVE: Immunohistochemistry results were correlated with electrophysiological variables to examine the immunopathogenesis of this disorder. DESIGN/SETTING: Laboratory studies used normal nerve tissue that was exposed to sera from 12 IP patients; 10 exposed controls; and 10 unexposed controls...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29386298/longitudinal-profiling-of-the-lung-microbiome-in-the-aeris-study-demonstrates-repeatability-of-bacterial-and-eosinophilic-copd-exacerbations
#15
David Mayhew, Nathalie Devos, Christophe Lambert, James R Brown, Stuart C Clarke, Viktoriya L Kim, Michal Magid-Slav, Bruce E Miller, Kristoffer K Ostridge, Ruchi Patel, Ganesh Sathe, Daniel F Simola, Karl J Staples, Ruby Sung, Ruth Tal-Singer, Andrew C Tuck, Stephanie Van Horn, Vincent Weynants, Nicholas P Williams, Jeanne-Marie Devaster, Tom M A Wilkinson
BACKGROUND: Alterations in the composition of the lung microbiome associated with adverse clinical outcomes, known as dysbiosis, have been implicated with disease severity and exacerbations in COPD. OBJECTIVE: To characterise longitudinal changes in the lung microbiome in the AERIS study (Acute Exacerbation and Respiratory InfectionS in COPD) and their relationship with associated COPD outcomes. METHODS: We surveyed 584 sputum samples from 101 patients with COPD to analyse the lung microbiome at both stable and exacerbation time points over 1 year using high-throughput sequencing of the 16S ribosomal RNA gene...
May 2018: Thorax
https://www.readbyqxmd.com/read/29358649/genome-wide-analysis-of-multi-and-extensively-drug-resistant-mycobacterium-tuberculosis
#16
Francesc Coll, Jody Phelan, Grant A Hill-Cawthorne, Mridul B Nair, Kim Mallard, Shahjahan Ali, Abdallah M Abdallah, Saad Alghamdi, Mona Alsomali, Abdallah O Ahmed, Stephanie Portelli, Yaa Oppong, Adriana Alves, Theolis Barbosa Bessa, Susana Campino, Maxine Caws, Anirvan Chatterjee, Amelia C Crampin, Keertan Dheda, Nicholas Furnham, Judith R Glynn, Louis Grandjean, Dang Minh Ha, Rumina Hasan, Zahra Hasan, Martin L Hibberd, Moses Joloba, Edward C Jones-López, Tomoshige Matsumoto, Anabela Miranda, David J Moore, Nora Mocillo, Stefan Panaiotov, Julian Parkhill, Carlos Penha, João Perdigão, Isabel Portugal, Zineb Rchiad, Jaime Robledo, Patricia Sheen, Nashwa Talaat Shesha, Frik A Sirgel, Christophe Sola, Erivelton Oliveira Sousa, Elizabeth M Streicher, Paul Van Helden, Miguel Viveiros, Robert M Warren, Ruth McNerney, Arnab Pain, Taane G Clark
To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mixed-regression framework was followed by a phylogenetics-based test for independent mutations. In addition to mutations in established and recently described resistance-associated genes, novel mutations were discovered for resistance to cycloserine, ethionamide and para-aminosalicylic acid...
February 2018: Nature Genetics
https://www.readbyqxmd.com/read/29317751/methylation-in-mycobacterium-tuberculosis-is-lineage-specific-with-associated-mutations-present-globally
#17
Jody Phelan, Paola Florez de Sessions, Leopold Tientcheu, Joao Perdigao, Diana Machado, Rumina Hasan, Zahra Hasan, Indra L Bergval, Richard Anthony, Ruth McNerney, Martin Antonio, Isabel Portugal, Miguel Viveiros, Susana Campino, Martin L Hibberd, Taane G Clark
DNA methylation is an epigenetic modification of the genome involved in regulating crucial cellular processes, including transcription and chromosome stability. Advances in PacBio sequencing technologies can be used to robustly reveal methylation sites. The methylome of the Mycobacterium tuberculosis complex is poorly understood but may be involved in virulence, hypoxic survival and the emergence of drug resistance. In the most extensive study to date, we characterise the methylome across the 4 major lineages of M...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29305308/mast-cell-activation-syndrome-mimicking-breast-cancer-case-report-with-pathophysiologic-considerations
#18
Gerhard J Molderings, Ruth Knüchel-Clarke, Hans-Jörg Hertfelder, Christiane Kuhl
No abstract text is available yet for this article.
December 12, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29298069/identification-of-n-cis-3-methyl-7h-pyrrolo-2-3-d-pyrimidin-4-yl-amino-cyclobutyl-propane-1-sulfonamide-pf-04965842-a-selective-jak1-clinical-candidate-for-the-treatment-of-autoimmune-diseases
#19
Michael L Vazquez, Neelu Kaila, Joseph W Strohbach, John D Trzupek, Matthew F Brown, Mark E Flanagan, Mark J Mitton-Fry, Timothy A Johnson, Ruth E TenBrink, Eric P Arnold, Arindrajit Basak, Steven E Heasley, Soojin Kwon, Jonathan Langille, Mihir D Parikh, Sarah H Griffin, Jeffrey M Casavant, Brian A Duclos, Ashley E Fenwick, Thomas M Harris, Seungil Han, Nicole Caspers, Martin E Dowty, Xin Yang, Mary Ellen Banker, Martin Hegen, Peter T Symanowicz, Li Li, Lu Wang, Tsung H Lin, Jason Jussif, James D Clark, Jean-Baptiste Telliez, Ralph P Robinson, Ray Unwalla
Janus kinases (JAKs) are intracellular tyrosine kinases that mediate the signaling of numerous cytokines and growth factors involved in the regulation of immunity, inflammation, and hematopoiesis. As JAK1 pairs with JAK2, JAK3, and TYK2, a JAK1-selective inhibitor would be expected to inhibit many cytokines involved in inflammation and immune function while avoiding inhibition of the JAK2 homodimer regulating erythropoietin and thrombopoietin signaling. Our efforts began with tofacitinib, an oral JAK inhibitor approved for the treatment of rheumatoid arthritis...
February 8, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29247113/outcomes-of-specialist-discharge-coordination-and-intermediate-care-schemes-for-patients-who-are-homeless-analysis-protocol-for-a-population-based-historical-cohort
#20
Ruth M Blackburn, Andrew Hayward, Michelle Cornes, Martin McKee, Dan Lewer, Martin Whiteford, Dee Menezes, Serena Luchenski, Alistair Story, Spiros Denaxas, Michela Tinelli, Fatima B Wurie, Richard Byng, Michael C Clark, James Fuller, Mark Gabbay, Nigel Hewett, Alan Kilmister, Jill Manthorpe, Joanne Neale, Robert W Aldridge
INTRODUCTION: People who are homeless often experience poor hospital discharge arrangements, reflecting ongoing care and housing needs. Specialist integrated homeless health and care provision (SIHHC) schemes have been developed and implemented to facilitate the safe and timely discharge of homeless patients from hospital. Our study aims to investigate the health outcomes of patients who were homeless and seen by a selection of SIHHC services. METHODS AND ANALYSIS: Our study will employ a historical population-based cohort in England...
December 14, 2017: BMJ Open
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