keyword
MENU ▼
Read by QxMD icon Read
search

cognitive overload

keyword
https://www.readbyqxmd.com/read/29126071/%C3%AE-lipoic-acid-improves-abnormal-behavior-by-mitigation-of-oxidative-stress-inflammation-ferroptosis-and-tauopathy-in-p301s-tau-transgenic-mice
#1
Yan-Hui Zhang, Da-Wei Wang, Shuang-Feng Xu, Shuai Zhang, Yong-Gang Fan, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Zhan-You Wang, Chuang Guo
Alzheimer's disease (AD) is the most common neurodegenerative disease and is characterized by neurofibrillary tangles (NFTs) composed of Tau protein. α-Lipoic acid (LA) has been found to stabilize the cognitive function of AD patients, and animal study findings have confirmed its anti-amyloidogenic properties. However, the underlying mechanisms remain unclear, especially with respect to the ability of LA to control Tau pathology and neuronal damage. Here, we found that LA supplementation effectively inhibited the hyperphosphorylation of Tau at several AD-related sites, accompanied by reduced cognitive decline in P301S Tau transgenic mice...
November 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/29089345/loss-of-female-sex-hormones-exacerbates-cerebrovascular-and-cognitive-dysfunction-in-aortic-banded-miniswine-through-a-neuropeptide-y-ca-2-activated-potassium-channel-nitric-oxide-mediated-mechanism
#2
T Dylan Olver, Jessica A Hiemstra, Jenna C Edwards, Todd R Schachtman, Cheryl M Heesch, Paul J Fadel, M Harold Laughlin, Craig A Emter
BACKGROUND: Postmenopausal women represent the largest cohort of patients with heart failure with preserved ejection fraction, and vascular dementia represents the most common form of dementia in patients with heart failure with preserved ejection fraction. Therefore, we tested the hypotheses that the combination of cardiac pressure overload (aortic banding [AB]) and the loss of female sex hormones (ovariectomy [OVX]) impairs cerebrovascular control and spatial memory. METHODS AND RESULTS: Female Yucatan miniswine were separated into 4 groups (n=7 per group): (1) control, (2) AB, (3) OVX, and (4) AB-OVX...
October 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29078915/effects-of-a-novel-mental-skills-curriculum-on-surgical-novices-attention
#3
RANDOMIZED CONTROLLED TRIAL
Nicholas E Anton, Neelam Mulji, Lisa D Howley, Ashley M Yurco, Daniel Tobben, Eric Bean, Dimitrios Stefanidis
BACKGROUND: Surgery is very cognitively demanding, particularly for novices. Novices are required to direct full attention on the procedure at hand, and additional demands can lead to cognitive overload. Through extensive practice, experts develop spare attentional capacity (SAC) for simultaneous tasks. However, little effort has been made to enhance novices' SAC. Mental skills may enhance attention management and increase SAC. The purpose of this study was to determine the efficacy of a novel mental skills curriculum (MSC) to enhance novices' attention management...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29060764/how-the-workload-impacts-on-cognitive-cooperation-a-pilot-study
#4
Nicolina Sciaraffa, Gianluca Borghini, Pietro Arico, Gianluca Di Flumeri, Jlenia Toppi, Alfredo Colosimo, Anastatios Bezerianos, Nitish V Thakor, Fabio Babiloni
Cooperation degradation can be seen as one of the main causes of human errors. Poor cooperation could arise from aberrant mental processes, such as mental overload, that negatively affect the user's performance. Using different levels of difficulty in a cooperative task, we combined behavioural, subjective and neurophysiological data with the aim to i) quantify the mental workload under which the crew was operating, ii) evaluate the degree of their cooperation, and iii) assess the impact of the workload demands on the cooperation levels...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29057453/5-ht1f-receptor-mediated-mitochondrial-biogenesis-for-the-treatment-of-parkinson-s-disease
#5
Natalie E Scholpa, Mary K Lynn, Daniel Corum, Heather A Boger, Rick G Schnellmann
BACKGROUND AND PURPOSE: Parkinson's disease is characterized by progressive decline in motor function due to degeneration of nigrostriatal dopaminergic neurons, as well as other deficits including cognitive impairment and behavioral abnormalities. Mitochondrial dysfunction, leading to loss of ATP-dependent cellular functions, calcium overload, excitotoxicity and oxidative stress, is implicated in the pathophysiology of Parkinson's disease. Using the 5-HT1F receptor agonist LY344864, a known inducer of mitochondrial biogenesis (MB), this study investigated the therapeutic efficacy of stimulating MB on dopaminergic neuron loss in a mouse model of Parkinson's disease...
October 22, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29038245/mitochondrial-calcium-dysregulation-contributes-to-dendrite-degeneration-mediated-by-pd-lbd-associated-lrrk2-mutants
#6
Manish Verma, Jason Callio, P Anthony Otero, Israel Sekler, Zachary P Wills, Charleen T Chu
Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to development of late-onset familial Parkinson's disease (PD), with clinical features of motor and cognitive dysfunction indistinguishable from sporadic PD. Calcium dysregulation plays an important role in PD pathogenesis, but the mechanisms of neurodegeneration remain unclear. Recent reports indicate enhanced excitatory neurotransmission in cortical neurons expressing mutant LRRK2, which occurs prior to the well-characterized phenotype of dendritic shortening...
October 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29016693/driving-simulator-scenarios-and-measures-to-faithfully-evaluate-risky-driving-behavior-a-comparative-study-of-different-driver-age-groups
#7
COMPARATIVE STUDY
Jesse Michaels, Romain Chaumillon, David Nguyen-Tri, Donald Watanabe, Pierro Hirsch, Francois Bellavance, Guillaume Giraudet, Delphine Bernardin, Jocelyn Faubert
To investigate the links between mental workload, age and risky driving, a cross-sectional study was conducted on a driving simulator using several established and some novel measures of driving ability and scenarios of varying complexity. A sample of 115 drivers was divided into three age and experience groups: young inexperienced (18-21 years old), adult experienced (25-55 years old) and older adult (70-86 years old). Participants were tested on three different scenarios varying in mental workload from low to high...
2017: PloS One
https://www.readbyqxmd.com/read/28960145/intergenerational-ambivalence-and-dyadic-strain-understanding-stress-in-family-care-partners-of-older-adults
#8
Jillian Pine, Ann M Steffen
OBJECTIVES: The present study used Pearlin, Mullan, Semple & Skaff's (1990) caregiving stress process model as a framework to examine the comparative influence of two stressors: (a) intergenerational ambivalence as a unified construct and (b) dyadic strain, which is one isolated component of intergenerational ambivalence. METHODS: Participants were 120 women providing healthcare and medication assistance to an earlier generation family member with physical and/or cognitive impairments...
July 28, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28915871/virtual-patients-in-the-acquisition-of-clinical-reasoning-skills-does-presentation-mode-matter-a-quasi-randomized-controlled-trial
#9
Fabian Schubach, Matthias Goos, Götz Fabry, Werner Vach, Martin Boeker
BACKGROUND: The objective of this study is to compare two different instructional methods in the curricular use of computerized virtual patients in undergraduate medical education. We aim to investigate whether using many short and focused cases - the key feature principle - is more effective for the learning of clinical reasoning skills than using few long and systematic cases. METHODS: We conducted a quasi-randomized, non-blinded, controlled parallel-group intervention trial in a large medical school in Southwestern Germany...
September 15, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28899812/the-starving-brain-overfed-meets-undernourished-in-the-pathology-of-mild-cognitive-impairment-mci-and-alzheimer-s-disease-ad
#10
REVIEW
Kelly J Gibas
Type II Diabetes affects 400 million people worldwide (IDF, 2013). The pathology is paradoxical: internal starvation activated by overfeeding. Hyperinsulinemic impairments of glucose homeostasis are treated with anti-hyperglycemics exacerbating cell starvation, inducing hypoglycemia and raising respiratory quotient. Reductions in hyperglycemia are achieved at the expense of glucose dependency and metabolic inflexibility (Gibas & Gibas, 2017). The brain is not immune from these cycles of starvation. The bioenergetic model characterizes propagation of late-onset, sporadic Alzheimer's disease as loss of molecular fidelity and compromised energy originating in brain networks with highest metabolic demand...
November 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28882750/grey-areas-new-zealand-ambulance-personnel-s-experiences-of-challenging-resuscitation-decision-making
#11
Natalie Elizabeth Anderson, Merryn Gott, Julia Slark
INTRODUCTION: When faced with a patient in cardiac arrest, ambulance personnel must rapidly make complex decisions with limited information. Much of the research examining decisions to commence, continue, withhold or terminate resuscitation has used retrospective audits of registry data and clinical documentation. This study offers a provider-perspective which characterises uncertainty and highlights clinical, cognitive, emotional and physical demands associated with decision-making in the cardiac arrest context...
September 4, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28862266/genomic-and-epigenomic-mechanisms-of-glucocorticoids-in-the-brain
#12
REVIEW
Jason D Gray, Joshua F Kogan, Jordan Marrocco, Bruce S McEwen
Following the discovery of glucocorticoid receptors in the hippocampus and other brain regions, research has focused on understanding the effects of glucocorticoids in the brain and their role in regulating emotion and cognition. Glucocorticoids are essential for adaptation to stressors (allostasis) and in maladaptation resulting from allostatic load and overload. Allostatic overload, which can occur during chronic stress, can reshape the hypothalamic-pituitary-adrenal axis through epigenetic modification of genes in the hippocampus, hypothalamus and other stress-responsive brain regions...
November 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28856337/neurobiological-and-systemic-effects-of-chronic-stress
#13
Bruce S McEwen
The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as the behavioral and physiological responses to the stressor, which promote adaptation ("allostasis") but also contribute to pathophysiology ("allostatic load/overload") when overused and dysregulated. The adult as well as developing brain possesses a remarkable ability to show structural and functional plasticity in response to stressful and other experiences, including neuronal replacement, dendritic remodeling and synapse turnover...
January 2017: Chronic stress
https://www.readbyqxmd.com/read/28854205/the-more-total-cognitive-load-is-reduced-by-cues-the-better-retention-and-transfer-of-multimedia-learning-a-meta-analysis-and-two-meta-regression-analyses
#14
Heping Xie, Fuxing Wang, Yanbin Hao, Jiaxue Chen, Jing An, Yuxin Wang, Huashan Liu
Cueing facilitates retention and transfer of multimedia learning. From the perspective of cognitive load theory (CLT), cueing has a positive effect on learning outcomes because of the reduction in total cognitive load and avoidance of cognitive overload. However, this has not been systematically evaluated. Moreover, what remains ambiguous is the direct relationship between the cue-related cognitive load and learning outcomes. A meta-analysis and two subsequent meta-regression analyses were conducted to explore these issues...
2017: PloS One
https://www.readbyqxmd.com/read/28827155/effects-of-mental-workload-on-involuntary-attention-a-somatosensory-erp-study
#15
Sungchul Mun, Mincheol Whang, Sangin Park, Min-Chul Park
Previous psychophysiological assessments of mental workload have relied on the addition of visual or auditory stimuli. This study investigated the tactile ERP and EEG spectral power correlates of mental workload by relating limited-capacity involuntary attention allocation to changes in late positive potential (LPP) amplitude, alpha, and theta powers. We examined whether mental workload (high-level cognitive control) can be evaluated using somatosensory stimuli. Sixteen participants all performed three tasks of varying difficulty...
August 18, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28827127/temporary-removal-evidence-for-a-role-of-plasma-membrane-calcium-pumps-in-neurodegenerative-disease-recent-developments
#16
Emanuel E Strehler, Stanley A Thayer
No abstract text is available yet for this article.
August 19, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28821470/design-of-the-drepagreffe-trial-a-prospective-controlled-multicenter-study-evaluating-the-benefit-of-genoidentical-hematopoietic-stem-cell-transplantation-over-chronic-transfusion-in-sickle-cell-anemia-children-detected-to-be-at-risk-of-stroke-by-transcranial
#17
Sylvie Chevret, Suzanne Verlhac, Elisabeth Ducros-Miralles, Jean-Hugues Dalle, Regis Peffault de Latour, Mariane de Montalembert, Malika Benkerrou, Corinne Pondarré, Isabelle Thuret, Corinne Guitton, Emmanuelle Lesprit, Maryse Etienne-Julan, Gisèle Elana, Jean-Pierre Vannier, Patrick Lutz, Bénédicte Neven, Claire Galambrun, Catherine Paillard, Camille Runel, Charlotte Jubert, Cécile Arnaud, Annie Kamdem, Valentine Brousse, Florence Missud, Marie Petras, Lydia Doumdo-Divialle, Claire Berger, Françoise Fréard, Olivier Taieb, Elise Drain, Monique Elmaleh, Manuela Vasile, Yacine Khelif, Myriam Bernaudin, Philippe Chadebech, France Pirenne, Gérard Socié, Françoise Bernaudin
BACKGROUND: Children with sickle cell anemia (SCA) have an 11% risk of stroke by the age of 18. Chronic transfusion applied in patients detected to be at risk by transcranial Doppler allows a significant reduction of stroke risk. However, chronic transfusion exposes to several adverse events, including alloimmunization and iron overload, and is not curative. Hematopoietic stem cell transplantation allows termination of the transfusion program, but its benefit has not been demonstrated...
November 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28802436/quantifying-the-cognitive-cost-of-laparo-endoscopic-single-site-surgeries-gaze-based-indices
#18
Leandro L Di Stasi, Carolina Díaz-Piedra, Juan Francisco Ruiz-Rabelo, Héctor Rieiro, Jose M Sanchez Carrion, Andrés Catena
BACKGROUND: Despite the growing interest concerning the laparo-endoscopic single-site surgery (LESS) procedure, LESS presents multiple difficulties and challenges that are likely to increase the surgeon's cognitive cost, in terms of both cognitive load and performance. Nevertheless, there is currently no objective index capable of assessing the surgeon cognitive cost while performing LESS. We assessed if gaze-based indices might offer unique and unbiased measures to quantify LESS complexity and its cognitive cost...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28763355/regulatory-considerations-for-physiological-closed-loop-controlled-medical-devices-used-for-automated-critical-care-food-and-drug-administration-workshop-discussion-topics
#19
Bahram Parvinian, Christopher Scully, Hanniebey Wiyor, Allison Kumar, Sandy Weininger
Part of the mission of the Center for Devices and Radiological Health (CDRH) at the US Food and Drug Administration is to facilitate medical device innovation. Therefore, CDRH plays an important role in helping its stakeholders such as manufacturers, health care professionals, patients, patient advocates, academia, and other government agencies navigate the regulatory landscape for medical devices. This is particularly important for innovative physiological closed-loop controlled (PCLC) devices used in critical care environments, such as intensive care units, emergency settings, and battlefield environments...
July 28, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28761885/self-directed-learning-barriers-in-a-virtual-environment-a-qualitative-study
#20
Noushin Kohan, Kamran Soltani Arabshahi, Rita Mojtahedzadeh, Abbas Abbaszadeh, Tayebeh Rakhshani, Amirhousein Emami
INTRODUCTION: There is a growing trend in online education courses in higher education institutes. Previous studies have shown that high levels of self-direction are essential for successful online learning. The present study aims to investigate challenges of and barriers to self-directed virtual-learning among postgraduate students of medical sciences. METHOD: 23 postgraduate virtual students of medical sciences in Iran, collected through maximum variation purposive sampling and semi-structured interviews, served as the sample of this study...
July 2017: Journal of Advances in Medical Education & Professionalism
keyword
keyword
118905
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"