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https://www.readbyqxmd.com/read/28712343/overload-from-anxiety-a-non-motor-cause-for-gait-impairments-in-parkinson-s-disease
#1
Kaylena A Ehgoetz Martens, Carolina R A Silveira, Brittany N Intzandt, Quincy J Almeida
Threatening situations lead to observable gait deficits in individuals with Parkinson's disease (PD) who suffer from high trait anxiety levels. The specific characteristics of gait that are affected appear to be similar to behaviors observed while walking during a dual-task (DT) condition. Yet, it remains unclear whether anxiety is similar to a cognitive load. If it were, then those with PD who have high trait anxiety might be expected to be more susceptible to DT interference during walking. Thus, the overall aim of this study was to evaluate whether trait anxiety influences gait during single-task (ST) and DT walking...
July 17, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28644490/potentiating-role-of-copper-on-spatial-memory-deficit-induced-by-beta-amyloid-and-evaluation-of-mitochondrial-function-markers-in-the-hippocampus-of-rats
#2
Ladan Behzadfar, Mohammad Abdollahi, Omid Sabzevari, Rohollah Hosseini, Ahmad Salimi, Parvaneh Naserzadeh, Mohammad Sharifzadeh, Jalal Pourahmad
Mounting evidence suggests that copper, a crucial element in normal brain function, plays an important role in the etiology of Alzheimer's disease, which is known as a neurodegenerative mitochondrial disorder. However, the precise mechanisms of its effects on cognitive and mitochondrial functions through the CNS have not been thoroughly recognized yet. In this study, we aimed to investigate the long-term (3-week) effects of copper sulfate (50, 100 and 200 mg kg(-1) day(-1)) exposure on learning and memory as well as on mitochondrial function in the hippocampus of rats in the presence and absence of beta amyloid (1 μg μl(-1) per side) intrahippocampally (IH)...
July 19, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28548091/cellular-interplay-via-cytokine-hierarchy-causes-pathological-cardiac-hypertrophy-in-raf1-mutant-noonan-syndrome
#3
Jiani C Yin, Mathew J Platt, Xixi Tian, Xue Wu, Peter H Backx, Jeremy A Simpson, Toshiyuki Araki, Benjamin G Neel
Noonan syndrome (NS) is caused by mutations in RAS/ERK pathway genes, and is characterized by craniofacial, growth, cognitive and cardiac defects. NS patients with kinase-activating RAF1 alleles typically develop pathological left ventricular hypertrophy (LVH), which is reproduced in Raf1(L613V/+) knock-in mice. Here, using inducible Raf1(L613V) expression, we show that LVH results from the interplay of cardiac cell types. Cardiomyocyte Raf1(L613V) enhances Ca(2+) sensitivity and cardiac contractility without causing hypertrophy...
May 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28448453/working-memory-in-the-prefrontal-cortex
#4
REVIEW
Shintaro Funahashi
The prefrontal cortex participates in a variety of higher cognitive functions. The concept of working memory is now widely used to understand prefrontal functions. Neurophysiological studies have revealed that stimulus-selective delay-period activity is a neural correlate of the mechanism for temporarily maintaining information in working memory processes. The central executive, which is the master component of Baddeley's working memory model and is thought to be a function of the prefrontal cortex, controls the performance of other components by allocating a limited capacity of memory resource to each component based on its demand...
April 27, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28424602/assessing-the-driver-s-current-level-of-working-memory-load-with-high-density-functional-near-infrared-spectroscopy-a-realistic-driving-simulator-study
#5
Anirudh Unni, Klas Ihme, Meike Jipp, Jochem W Rieger
Cognitive overload or underload results in a decrease in human performance which may result in fatal incidents while driving. We envision that driver assistive systems which adapt their functionality to the driver's cognitive state could be a promising approach to reduce road accidents due to human errors. This research attempts to predict variations of cognitive working memory load levels in a natural driving scenario with multiple parallel tasks and to reveal predictive brain areas. We used a modified version of the n-back task to induce five different working memory load levels (from 0-back up to 4-back) forcing the participants to continuously update, memorize, and recall the previous 'n' speed sequences and adjust their speed accordingly while they drove for approximately 60 min on a highway with concurrent traffic in a virtual reality driving simulator...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28399463/distraction-or-cognitive-overload-using-modulations-of-the-autonomic-nervous-system-to-discriminate-the-possible-negative-effects-of-advanced-assistance-system
#6
D Ruscio, A J Bos, M R Ciceri
The interaction with Advanced Driver Assistance Systems has several positive implications for road safety, but also some potential downsides such as mental workload and automation complacency. Malleable attentional resources allocation theory describes two possible processes that can generate workload in interaction with advanced assisting devices. The purpose of the present study is to determine if specific analysis of the different modalities of autonomic control of nervous system can be used to discriminate different potential workload processes generated during assisted-driving tasks and automation complacency situations...
June 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28395667/effects-of-workload-work-complexity-and-repeated-alerts-on-alert-fatigue-in-a-clinical-decision-support-system
#7
Jessica S Ancker, Alison Edwards, Sarah Nosal, Diane Hauser, Elizabeth Mauer, Rainu Kaushal
BACKGROUND: Although alert fatigue is blamed for high override rates in contemporary clinical decision support systems, the concept of alert fatigue is poorly defined. We tested hypotheses arising from two possible alert fatigue mechanisms: (A) cognitive overload associated with amount of work, complexity of work, and effort distinguishing informative from uninformative alerts, and (B) desensitization from repeated exposure to the same alert over time. METHODS: Retrospective cohort study using electronic health record data (both drug alerts and clinical practice reminders) from January 2010 through June 2013 from 112 ambulatory primary care clinicians...
April 10, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28334149/higher-striatal-iron-concentration-is-linked-to-frontostriatal-underactivation-and-poorer-memory-in-normal-aging
#8
Grégoria Kalpouzos, Benjamín Garzón, Rouslan Sitnikov, Carmel Heiland, Alireza Salami, Jonas Persson, Lars Bäckman
In the brain, intracellular iron is essential for cellular metabolism. However, an overload of free iron is toxic, inducing oxidative stress and cell death. Although an increase of striatal iron has been related to atrophy and impaired cognitive performance, the link between elevated iron and altered brain activity in aging remains unexplored. In a sample of 37 younger and older adults, we examined whether higher striatal iron concentration could underlie age-related differences in frontostriatal activity induced by mental imagery of motor and non-motor scenes, and poorer recall of the scenes...
June 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28298276/early-life-nutritional-programming-of-cognition-the-fundamental-role-of-epigenetic-mechanisms-in-mediating-the-relation-between-early-life-environment-and-learning-and-memory-process
#9
REVIEW
Laura Moody, Hong Chen, Yuan-Xiang Pan
The perinatal period is a window of heightened plasticity that lays the groundwork for future anatomic, physiologic, and behavioral outcomes. During this time, maternal diet plays a pivotal role in the maturation of vital organs and the establishment of neuronal connections. However, when perinatal nutrition is either lacking in specific micro- and macronutrients or overloaded with excess calories, the consequences can be devastating and long lasting. The brain is particularly sensitive to perinatal insults, with several neurologic and psychiatric disorders having been linked to a poor in utero environment...
March 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28291277/diagnostiska-fel-och-misstag-%C3%A3-r-vanliga-och-sv%C3%A3-ra-att-m%C3%A3-ta
#10
Anders von Heijne
Diagnostic errors are prevalent and hard to measure Diagnostic errors are prevalent in all aspects of healthcare and a common cause of adverse events. They are often the result of multifactorial events, where there is a complex interplay between cognitive factors, system factors and lack of adequate knowledge. The generic, iterative diagnostic process, with abductive, deductive and inductive components supported by tests and the physical exam, leads to a correct diagnosis for the great majority of patients, but can be derailed by suboptimal thinking, lack of adequate information and external factors such as stress and work overload...
March 13, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28287803/benefit-finding-and-effect-on-caregiver-depression-a-double-blind-randomized-controlled-trial
#11
Sheung-Tak Cheng, Emily P M Mak, Helene H Fung, Timothy Kwok, Diana T F Lee, Linda C W Lam
OBJECTIVE: To examine the effects of using cognitive reappraisal to find positive gains on caregivers' depressive symptoms, burden, and psychological well-being. METHOD: Ninety-six caregivers of persons with Alzheimer's disease were randomly assigned to receive a benefit-finding intervention or 1 of 2 treatment-as-usual conditions, namely, simplified psychoeducation (lectures only; SIM-PE) or standard psychoeducation (STD-PE). Each participant received 4 biweekly interventions of 3 hr each, over a 2-month period, at home...
May 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28249040/effects-of-deferoxamine-on-blood-brain-barrier-disruption-after-subarachnoid-hemorrhage
#12
Yanjiang Li, Heng Yang, Wei Ni, Yuxiang Gu
Blood brain barrier (BBB) disruption is a key mechanism of subarachnoid hemorrhage (SAH)-induced brain injury. This study examined the mechanism of iron-induced BBB disruption after SAH and investigated the potential therapeutic effect of iron chelation on SAH. Male adult Sprague-Dawley rats had an endovascular perforation of left internal carotid artery bifurcation or sham operation. The rats were treated with deferoxamine (DFX) or vehicle (100mg/kg) for a maximum of 7 days. Brain edema, BBB leakage, behavioral and cognitive impairment were examined...
2017: PloS One
https://www.readbyqxmd.com/read/28231024/incorporating-behavioral-techniques-into-a-serious-videogame-for-children
#13
Debbe Thompson
INTRODUCTION: Little is known about how to design serious videogames for children. The purpose of this article is to describe how behavior change techniques promoting self-regulation were incorporated into a serious videogame to help children consume more fruits and vegetables (FVs) and the extent to which these techniques were used by players. A secondary goal is to contribute to the body of scientific knowledge regarding how to design effective serious videogames for children. MATERIALS AND METHODS: This research examines the gameplay data from an effective 10-episode online serious videogame promoting FV consumption to preadolescent children in the United States (roughly 9-11-year-olds)...
April 2017: Games for Health
https://www.readbyqxmd.com/read/28225852/tryptophan-overloading-activates-brain-regions-involved-with-cognition-mood-and-anxiety
#14
Luana C A Silva, Milena B Viana, José S Andrade, Melyssa A Souza, Isabel C Céspedes, Vânia D'Almeida
Tryptophan is the only precursor of serotonin and mediates serotonergic activity in the brain. Previous studies have shown that the administration of tryptophan or tryptophan depletion significantly alters cognition, mood and anxiety. Nevertheless, the neurobiological alterations that follow these changes have not yet been fully investigated. The aim of this study was to verify the effects of a tryptophan-enriched diet on immunoreactivity to Fos-protein in the rat brain. Sixteen male Wistar rats were distributed into two groups that either received standard chow diet or a tryptophan-enriched diet for a period of thirty days...
January 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28212704/neurochemical-differences-in-learning-and-memory-paradigms-among-rats-supplemented-with-anthocyanin-rich-blueberry-diets-and-exposed-to-acute-doses-of-56-fe-particles
#15
Shibu M Poulose, Bernard M Rabin, Donna F Bielinski, Megan E Kelly, Marshall G Miller, Nopporn Thanthaeng, Barbara Shukitt-Hale
The protective effects of anthocyanin-rich blueberries (BB) on brain health are well documented and are particularly important under conditions of high oxidative stress, which can lead to "accelerated aging." One such scenario is exposure to space radiation, consisting of high-energy and -charge particles (HZE), which are known to cause cognitive dysfunction and deleterious neurochemical alterations. We recently tested the behavioral and neurochemical effects of acute exposure to HZE particles such as (56)Fe, within 24-48h after exposure, and found that radiation primarily affects memory and not learning...
February 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28169349/dynamic-hub-load-predicts-cognitive-decline-after-resective-neurosurgery
#16
Ellen W S Carbo, Arjan Hillebrand, Edwin van Dellen, Prejaas Tewarie, Philip C de Witt Hamer, Johannes C Baayen, Martin Klein, Jeroen J G Geurts, Jaap C Reijneveld, Cornelis J Stam, Linda Douw
Resective neurosurgery carries the risk of postoperative cognitive deterioration. The concept of 'hub (over)load', caused by (over)use of the most important brain regions, has been theoretically postulated in relation to symptomatology and neurological disease course, but lacks experimental confirmation. We investigated functional hub load and postsurgical cognitive deterioration in patients undergoing lesion resection. Patients (n = 28) underwent resting-state magnetoencephalography and neuropsychological assessments preoperatively and 1-year after lesion resection...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28146674/rest-is-still-best
#17
William S Helton, Paul N Russell
OBJECTIVE: We examined the impact task interruptions of differing qualitative and quantitative load have on visuospatial vigilance sensitivity. BACKGROUND: The vigilance decrement and attempts to develop countermeasures to the decrement is one of the most important human factors issues. There is an ongoing debate between those who interpret the increase in the rate of failures to detect signals over time as being due to objective task monotony or task underload and those who interpret this increased failure proneness as being predominately due to cognitive-resource depletion and task overload...
February 2017: Human Factors
https://www.readbyqxmd.com/read/28109413/biobehavioral-factors-that-shape-nutrition-in-low-income-populations-a-narrative-review
#18
EDITORIAL
Barbara A Laraia, Tashara M Leak, June M Tester, Cindy W Leung
Although evidence exists for an association between income level and diet quality, a causal relationship has not been established. A number of studies found that the price of nutritious food and the time cost to prepare foods are economically driven reasons for this relationship. However, in addition to economic constraints, low-income individuals and families face a number of additional challenges linked with food choice, eating behaviors, and diet-related chronic conditions that contribute to diet quality and health...
February 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27964962/improving-community-ambulation-after-hip-fracture-protocol-for-a-randomised-controlled-trial
#19
D Orwig, K K Mangione, M Baumgarten, M Terrin, R Fortinsky, A M Kenny, A L Gruber-Baldini, B Beamer, Ana Tosteson, M Shardell, L Magder, E Binder, K Koval, B Resnick, R L Craik, J Magaziner
INTRODUCTION: After a hip fracture in older persons, significant disability often remains; dependency in functional activities commonly persists beyond 3 months after surgery. Endurance, dynamic balance, quadriceps strength, and function are compromised, and contribute to an inability to walk independently in the community. In the United States, people aged 65 years and older are eligible to receive Medicare funding for physiotherapy for a limited time after a hip fracture. A goal of outpatient physiotherapy is independent and safe household ambulation 2 to 3 months after surgery...
January 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/27899903/reading-touch-screen-storybooks-with-mothers-negatively-affects-7-year-old-readers-comprehension-but-enriches-emotional-engagement
#20
Kirsty M Ross, Rachel E Pye, Jordan Randell
Touch screen storybooks turn reading into an interactive multimedia experience, with hotspot-activated animations, sound effects, and games. Positive and negative effects of reading multimedia stories have been reported, but the underlying mechanisms which explain how children's learning is affected remain uncertain. The present study examined the effect of storybook format (touch screen and print) on story comprehension, and considered how level of touch screen interactivity (high and low) and shared reading behaviors (cognitive and emotional scaffolding, emotional engagement) might contribute to comprehension...
2016: Frontiers in Psychology
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