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https://www.readbyqxmd.com/read/29784876/chca-1-is-a-copper-regulated-ctr1-homolog-required-for-normal-development-copper-accumulation-and-copper-sensing-behavior-in-caenorhabditis-elegans
#1
Sai Yuan, Anuj Kumar Sharma, Alexandria Richart, Jaekwon Lee, Byung-Eun Kim
Copper (Cu) plays key roles in catalytic and regulatory biochemical reactions essential for normal growth, development, and health. Dietary Cu deficiencies or mutations in Cu homeostasis genes can lead to abnormal musculoskeletal development, cognitive disorders, and poor growth. In yeast and mammals, Cu is acquired through the activities of the Ctr1 family of high-affinity Cu transporters. However, the mechanisms of systemic responses to dietary or tissue-specific Cu deficiency remain unclear. Here, taking advantage of the animal model Caenorhabditis elegans for studying whole-body Cu homeostasis, we investigated the role of a C...
May 21, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29780118/a-10-year-follow-up-study-of-a-japanese-family-with-ferroportin-disease-a-mild-iron-overload-with-mild-hyperferritinemia-co-occurring-with-hyperhepcidinemia-may-be-benign
#2
Hisao Hayashi, Motoyoshi Yano, Naohito Urawa, Akane Mizutani, Shima Hamaoka, Jun Araki, Yuji Kojima, Yutaka Naito, Ayako Kato, Yasuaki Tatsumi, Koichi Kato
This is a 10-year follow-up study of a family with ferroportin disease A. The proband, a 59-year-old man showed no noteworthy findings with the exception of an abnormal iron level. The proband's 90-year-old father showed reduced abilities in gait and cognition; however, with the exception of his iron level, his biochemistry results were almost normal. Brain imaging showed age-matched atrophy and iron deposition. In both patients, the serum levels of ferritin and hepcidin25, and liver CT scores declined over a 10-year period...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29776002/the-chaos-of-hospitalisation-for-patients-with-critical-limb-ischaemia-approaching-major-amputation
#3
Susan Monaro, Sandra West, Jana Pinkova, Janice Gullick
AIMS AND OBJECTIVES: To illuminate the hospital experience for patients and families when major amputation has been advised for critical limb ischaemia (CLI). BACKGROUND: CLI creates significant burden to the health system and the family, particularly as the person with CLI approaches amputation. Major amputation is often offered as a late intervention for CLI in response to the marked deterioration of an ischaemic limb, and functional decline from reduced mobility, intractable pain, infection and/or toxaemia...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29724145/elizabeth-usher-memorial-lecture-how-do-we-change-our-profession-using-the-lens-of-behavioural-economics-to-improve-evidence-based-practice-in-speech-language-pathology
#4
Patricia J McCabe
Evidence-based practice (EBP) is a well-accepted theoretical framework around which speech-language pathologists strive to build their clinical decisions. The profession's conceptualisation of EBP has been evolving over the last 20 years with the practice of EBP now needing to balance research evidence, clinical data and informed patient choices. However, although EBP is not a new concept, as a profession, we seem to be no closer to closing the gap between research evidence and practice than we were at the start of the movement toward EBP in the late 1990s...
May 3, 2018: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29683713/overloaded-and-stressed-a-case-study-of-women-working-in-the-health-care-sector
#5
Maggie Stevenson, Linda Duxbury
Although role overload has been shown to be prevalent and consequential, there has been little attempt to develop the associated theory. The fact that the consequences of role overload can be positive or negative implies that the relationship between role overload and perceived stress depends partly on the environment within which role overload is experienced (i.e., the perceived situation) and how the situation is evaluated (i.e., appraised). Guided by cognitive appraisal theory, this study applies qualitative methodology to identify the situation properties that contribute to variable stress reactions to role overload...
April 23, 2018: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/29623030/on-the-role-of-store-operated-calcium-entry-in-acute-and-chronic-neurodegenerative-diseases
#6
REVIEW
Agnese Secondo, Giacinto Bagetta, Diana Amantea
In both excitable and non-excitable cells, calcium (Ca2+ ) signals are maintained by a highly integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of plasma membrane (PM) Ca2+ channels following the release of Ca2+ from intracellular stores. Upon depletion of Ca2+ store, the stromal interaction molecule (STIM) senses Ca2+ level reduction and migrates from endoplasmic reticulum (ER)-like sites to the PM where it activates the channel proteins Orai and/or the transient receptor potential channels (TRPC) prompting Ca2+ refilling...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29618742/early-life-stress-induces-long-term-changes-in-limbic-areas-of-a-teleost-fish-the-role-of-catecholamine-systems-in-stress-coping
#7
Marco A Vindas, Stefanos Fokos, Michail Pavlidis, Erik Höglund, Sylvia Dionysopoulou, Lars O E Ebbesson, Nikolaos Papandroulakis, Catherine R Dermon
Early life stress (ELS) shapes the way individuals cope with future situations. Animals use cognitive flexibility to cope with their ever-changing environment and this is mainly processed in forebrain areas. We investigated the performance of juvenile gilthead seabream, previously subjected to an ELS regime. ELS fish showed overall higher brain catecholaminergic (CA) signalling and lower brain derived neurotrophic factor (bdnf) and higher cfos expression in region-specific areas. All fish showed a normal cortisol and serotonergic response to acute stress...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29593605/eeg-correlates-of-the-flow-state-a-combination-of-increased-frontal-theta-and-moderate-frontocentral-alpha-rhythm-in-the-mental-arithmetic-task
#8
Kenji Katahira, Yoichi Yamazaki, Chiaki Yamaoka, Hiroaki Ozaki, Sayaka Nakagawa, Noriko Nagata
Flow experience is a subjective state experienced during holistic involvement in a certain activity, which has been reported to function as a factor promoting motivation, skill development, and better performance in the activity. To verify the positive effects of flow and develop a method to utilize it, the establishment of a reliable measurement of the flow state is essential. The present study utilized an electroencephalogram (EEG) during an experimentally evoked flow state and examined the possibility of objective measurement of immediate flow...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29593525/the-aging-of-iron-man
#9
REVIEW
Azhaar Ashraf, Maryam Clark, Po-Wah So
Brain iron is tightly regulated by a multitude of proteins to ensure homeostasis. Iron dyshomeostasis has become a molecular signature associated with aging which is accompanied by progressive decline in cognitive processes. A common theme in neurodegenerative diseases where age is the major risk factor, iron dyshomeostasis coincides with neuroinflammation, abnormal protein aggregation, neurodegeneration, and neurobehavioral deficits. There is a great need to determine the mechanisms governing perturbations in iron metabolism, in particular to distinguish between physiological and pathological aging to generate fruitful therapeutic targets for neurodegenerative diseases...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29582400/enhancing-endogenous-nitric-oxide-by-whole-body-periodic-acceleration-elicits-neuroprotective-effects-in-dystrophic-neurons
#10
Jose R Lopez, A Uryash, J Kolster, E Estève, R Zhang, J A Adams
We have previously shown that inadequate dystrophin in cortical neurons in mdx mice is associated with age-dependent dyshomeostasis of resting intracellular Ca2+ ([Ca2+ ]i ) and Na+ ([Na+ ]i ), elevated reactive oxygen species (ROS) production, increase in neuronal damage and cognitive deficit. In this study, we assessed the potential therapeutic properties of the whole body periodic acceleration (pGz) to ameliorate the pathology observed in cortical neurons from the mdx mouse. pGz adds small pulses to the circulation, thereby increasing pulsatile shear stress to the vascular endothelium, which in turn increases production of nitric oxide (NO)...
March 26, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29532057/association-of-excessive-daytime-sleepiness-with-longitudinal-%C3%AE-amyloid-accumulation-in-elderly-persons-without-dementia
#11
Diego Z Carvalho, Erik K St Louis, David S Knopman, Bradley F Boeve, Val J Lowe, Rosebud O Roberts, Michelle M Mielke, Scott A Przybelski, Mary M Machulda, Ronald C Petersen, Clifford R Jack, Prashanthi Vemuri
Importance: Aging is associated with excessive daytime sleepiness (EDS), which has been linked to cognitive decline in the elderly. However, whether EDS is associated with the pathologic processes of Alzheimer disease remains unclear. Objective: To investigate whether EDS at baseline is associated with a longitudinal increase in regional β-amyloid (Aβ) accumulation in a cohort of elderly individuals without dementia. Design, Setting, and Participants: This prospective analysis included participants enrolled in the Mayo Clinic Study of Aging, a longitudinal population-based study in Olmsted County, Minnesota...
March 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29510187/rhynchophylline-suppresses-soluble-a%C3%AE-1-42-induced-impairment-of-spatial-cognition-function-via-inhibiting-excessive-activation-of-extrasynaptic-nr2b-containing-nmda-receptors
#12
Yang Yang, Wei-Gang Ji, Zhi-Ru Zhu, Yu-Ling Wu, Zhi-Yang Zhang, Shao-Chen Qu
Rhynchophylline (RIN) is a significant active component isolated from the Chinese herbal medicine Uncaria rhynchophylla. The overproduction of soluble amyloid β protein (Aβ) oligomers in the hippocampus is closely involved in impairments in cognitive function at the early stage of Alzheimer's disease (AD). Growing evidences show that RIN possesses neuroprotective effects against Aβ-induced neurotoxicity. However, whether RIN can prevent soluble Aβ1-42 -induced impairments in spatial cognitive function and synaptic plasticity is still unclear...
March 3, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29462631/rapidly-dissolving-microneedle-patches-for-transdermal-iron-replenishment-therapy
#13
Abhijeet Maurya, Shivakumar H Nanjappa, Swati Honnavar, M Salwa, S Narasimha Murthy
The prevalence of iron deficiency anemia (IDA) is predominant in women and children especially in developing countries. The disorder affects cognitive functions and physical activity. Although oral iron supplementation and parenteral therapy remains the preferred choice of treatment, gastric side effects and risk of iron overload decreases adherence to therapy. Transdermal route is an established approach, which circumvents the side effects associated with conventional therapy. In this project, an attempt was made to investigate the use of rapidly dissolving microneedles loaded with ferric pyrophosphate (FPP) as a potential therapeutic approach for management of IDA...
February 17, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29458418/amyloid-%C3%AE-induced-impairments-on-mitochondrial-dynamics-hippocampal-neurogenesis-and-memory-are-restored-by-phosphodiesterase-7-inhibition
#14
Fernando Bartolome, Macarena de la Cueva, Consuelo Pascual, Desiree Antequera, Tamara Fernandez, Carmen Gil, Ana Martinez, Eva Carro
BACKGROUND: The phosphodiesterase (PDE) 7 inhibitor S14 is a cell-permeable small heterocyclic molecule that is able to cross the blood-brain barrier. We previously found that intraperitoneal treatment with S14 exerted neuroprotection in an Alzheimer's disease (AD) model (in APP/PS1 mice). The objective of this study was to investigate the neurogenic and cellular effects of oral administration of S14 on amyloid β (Aβ) overload. METHODS: We orally administered the PDE7 inhibitor S14 (15 mg/kg/day) or vehicle in 6-month-old APP/PS1 mice...
February 20, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29378621/novel-botanical-drug-da-9803-prevents-deficits-in-alzheimer-s-mouse-models
#15
Guillaume J Pagnier, Ksenia V Kastanenka, Miwon Sohn, Sangzin Choi, Song-Hyen Choi, HyeYeon Soh, Brian J Bacskai
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by deposition of amyloid plaques and disruption of neural circuitry, leading to cognitive decline. Animal models of AD deposit senile plaques and exhibit structural and functional deficits in neurons and neural networks. An effective treatment would prevent or restore these deficits, including calcium dyshomeostasis observed with in-vivo imaging. METHODS: We examined the effects of DA-9803, a multimodal botanical drug, in 5XFAD and APP/PS1 transgenic mice which underwent daily oral treatment with 30 or 100 mg/kg DA-9803 or vehicle alone...
January 29, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29368326/-spanish-translation-and-validation-of-the-neuromuscular-module-of-the-pediatric-quality-of-life-inventory-pedsql-evaluation-of-the-quality-of-life-perceived-by-the-parents-of-2-4-year-old-children-with-neuromuscular-diseases
#16
M Girabent-Farres, L Monne-Guasch, C Bagur-Calafat, J Fagoaga
INTRODUCTION: Paediatric neuromuscular disorders, which negatively impact on children's health-related quality of life (HRQoL), are a frequent cause of parental consultation with a physiotherapist. Parents' stress overload triggers a poor perception of their children's HRQoL. For this reason, it is essential to have psychometrically sound instrument to measure parent's perceptions such as the Pediatric Quality of Life Inventory (PedsQL) Neuromuscular Module. AIM: To assess the validity and reliability of the Spanish version of PedsQL Neuromuscular Module for parent perceived quality of life of children aged 2-4 with neuromuscular disorders...
February 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29350556/rehabilitation-of-a-young-athlete-with-extension-based-low-back-pain-addressing-motor-control-impairments-and-central-sensitization
#17
John J Winslow, Mark Jackson, Andrew Getzin, Michael Costello
OBJECTIVE:   To describe the conservative management of a young athlete with extension-based (EB) low back pain (LBP). BACKGROUND:   We present the case of a 15-year-old female high school gymnast with a 4-year history of EB LBP. Magnetic resonance imaging revealed a healed spondylolysis and significant atrophy with fatty infiltrate of the lumbar multifidi muscles (LMM). She had several courses of outpatient orthopaedic rehabilitation that focused on core muscle strengthening (improving activation and strength of the LMM and transversus abdominus muscle in a neutral pelvic position) without long-lasting improvement...
February 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29290330/affective-science-and-avoidant-end-of-life-communication-can-the-science-of-emotion-help-physicians-talk-with-their-patients-about-the-end-of-life
#18
Jesse A Soodalter, Greg J Siegle, Michele Klein-Fedyshin, Robert Arnold, Yael Schenker
Despite believing end-of-life (EOL) discussions with patients are important, doctors often do not have them. Multiple factors contribute to this shortfall, which interventions including reimbursement changes and communication skills training have not significantly improved to date. One commonly cited but under-researched reason for physician avoidance of EOL discussion is emotional difficulty. High occupational demand for frequent difficult discussions may overload physicians' normal emotional functioning, leading to avoidance or failure...
December 11, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/29283047/is-it-all-said-for-nsaids-in-alzheimer-s-disease-role-of-mitochondrial-calcium-uptake
#19
Sara Sanz-Blasco, Maria Calvo-Rodríguez, Erica Caballero, Monica Garcia-Durillo, Lucía Nunez, Carlos Villalobos
Epidemiological data suggest that non-steroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer's disease (AD). Unfortunately, recent trials have failed in providing compelling evidence of neuroprotection. Discussion as to why NSAIDs effectivity is uncertain is ongoing. Possible explanations include the view that NSAIDs and other possible disease-modifying drugs should be provided before the patients develop symptoms of AD or cognitive decline. In addition, NSAID targets for neuroprotection are unclear...
December 27, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29282900/barriers-to-effective-case-management-for-disabled-patients-on-hemodialysis
#20
Hidehiro Sugisawa, Yumiko Shimizu, Tamaki Kumagai, Hiroaki Sugisaki, Seiji Ohira, Toshio Shinoda
The present study examined the performance level and its related factors on the process of case management for disabled patients on hemodialysis. Case management performance was evaluated at three stages: patient assessment, making a care plan, and monitoring/evaluation. Candidates for targeting the factors relating to performance included four dimensions: nursing care level, physical malfunction, cognitive malfunction, and barriers to service were used as patient factors; the period of case management for the patient and the knowledge of dialysis emerged as case manager factors; work load was included as an organizational factor; and community resources for these services and communication with surrounding persons were included as system factors...
April 2018: Therapeutic Apheresis and Dialysis
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