keyword
MENU ▼
Read by QxMD icon Read
search

Trial sequential analysis

keyword
https://www.readbyqxmd.com/read/28231440/effects-of-acupressure-on-chemotherapy-induced-nausea-and-vomiting-a-systematic-review-with-meta-analyses-and-trial-sequential-analysis-of-randomized-controlled-trials
#1
REVIEW
Jing Miao, Xinyou Liu, Chaojun Wu, Hui Kong, Weiping Xie, Kouying Liu
BACKGROUND: Acupressure has been used as an effective way in treating with stomach upset. However the efficacy of acupressure in preventing chemotherapy-induced nausea and vomiting is uncertain. OBJECTIVE: To assess the effectiveness of acupressure on three categories of chemotherapy-induced nausea and vomiting. DATA SOURCES: Databases had been retrieved from inception through February 2016 for the randomized controlled trials in accordance with the inclusion criteria, including PubMed, Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, Science Direct, CINAHL, China Biology Medicine, Chinese National Knowledge infrastructure, Wan Fang and Database for Chinese Technical Periodicals...
February 14, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28230715/a-multireferral-centre-retrospective-cohort-analysis-on-the-experience-in-treatment-of-metastatic-uveal-melanoma-and-utilization-of-sequential-liver-directed-treatment-and-immunotherapy
#2
Malinda Itchins, Paolo A Ascierto, Alexander M Menzies, Meredith Oatley, Serigne Lo, Dariush Douraghi-Zadeh, Timmothy Harrington, Richard Maher, Antonio M Grimaldi, Alexander Guminski
Metastatic uveal melanoma is a rare malignancy with a poor prognosis. To date, systemic therapy has been ineffective; however, there are few data on the benefits of anti-CTLA4 or anti-PD-1 antibodies in sequence with liver-directed therapy. A retrospective cohort analysis was carried out on 37 consecutive patients managed in a tertiary referral centre examining the safety and efficacy of treatment; patterns of care; and impact on survival. The sequential treatment with transarterial chemotherapy (TAC), systemic immunotherapy (IT) and systemic chemotherapy was reviewed...
February 22, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28227809/feature-domain-specific-movement-intention-detection-for-stroke-rehabilitation-with-brain-computer-interfaces
#3
J T Hadsund, M B Sorensen, A C Royo, I K Niazi, H Rovsing, C Rovsing, M Jochumsen, J T Hadsund, M B Sorensen, A C Royo, I K Niazi, H Rovsing, C Rovsing, M Jochumsen, H Rovsing, M Jochumsen, M B Sorensen, C Rovsing, A C Royo, I K Niazi, J T Hadsund
Brain-computer interface (BCI) driven electrical stimulation has been proposed for neuromodulation for stroke rehabilitation by pairing intentions to move with somatosensory feedback from electrical stimulation. Movement intentions have been detected in several studies using different techniques, with temporal and spectral features being the most common. A few studies have compared temporal and spectral features, but conflicting results have been reported. In this study, the aim was to investigate if complexity measures can be used for movement intention detection and to compare the detection performance based on features extracted from three different domains (time, frequency and complexity) from single-trial EEG...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221205/muscle-relaxation-for-tracheal-intubation-during-paediatric-anaesthesia-a-meta-analysis-and-trial-sequential-analysis
#4
Florence Julien-Marsollier, Daphné Michelet, Myriam Bellon, Anne-Laure Horlin, Jean-Michel Devys, Souhayl Dahmani
BACKGROUND: Muscle relaxation for tracheal intubation during paediatric anaesthesia remains a subject of debate. OBJECTIVE: The aim of the current meta-analysis was to investigate the effect of muscle relaxants (MR) compared with opioids on intubation conditions in children. DESIGN: Meta-analysis of randomised controlled studies and GRADE analysis. DATA SOURCES: Exhaustive literature analysis. ELIGIBILITY CRITERIA: Clinical trials, with no high-risk bias, that examined the effect of MR in comparison with opioids on intubation conditions (excellent: primary outcome, acceptable: secondary outcome) in children were included...
February 17, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28219818/ultrasonic-versus-electrosurgical-device-for-laparoscopic-cholecystectomy-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#5
REVIEW
Hong-Peng Jiang, Ya-Dong Liu, Yan-Sen Li, Zhan-Long Shen, Ying-Jiang Ye
BACKGROUND: Ultrasonic and electrosurgical energy dissectors are main dissecting devices widely used for the laparoscopic cholecystectomy. Trial sequential analyses can establish whether firm evidence favoring a specific device has been reached from accumulated literature. To explore this, we performed a meta-analysis and trial sequential analyses. METHODS: PubMed, Embase, and the Cochrane Library were searched from inception to October 2016. The primary outcome was operative time...
February 17, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28215126/new-sepsis-definition-changes-incidence-of-sepsis-in-the-intensive-care-unit
#6
James N Fullerton, Kelly Thompson, Amith Shetty, Jonathan R Iredell, Harvey Lander, John A Myburgh, Simon Finfer
OBJECTIVE: To estimate the impact of adopting the proposed new diagnostic criteria for sepsis, based on Sequential Organ Failure Assessment (SOFA) criteria, on the diagnosis and apparent mortality of sepsis in Australian and New Zealand intensive care units. DESIGN, SETTING AND PARTICIPANTS: A two-stage, post hoc analysis of prospectively collected ICU research data from 3780 adult patients in 77 Australian and New Zealand ICUs on 7 study days, between 2009 and 2014...
March 2017: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/28211076/comparison-of-conditional-bias-adjusted-estimators-for-interim-analysis-in-clinical-trials-with-survival-data
#7
Masashi Shimura, Masahiko Gosho, Akihiro Hirakawa
Group sequential designs are widely used in clinical trials to determine whether a trial should be terminated early. In such trials, maximum likelihood estimates are often used to describe the difference in efficacy between the experimental and reference treatments; however, these are well known for displaying conditional and unconditional biases. Established bias-adjusted estimators include the conditional mean-adjusted estimator (CMAE), conditional median unbiased estimator, conditional uniformly minimum variance unbiased estimator (CUMVUE), and weighted estimator...
February 17, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28210499/the-effectiveness-of-slow-stroke-back-massage-on-hospitalization-anxiety-and-physiological-parameters-in-school-age-children-a-randomized-clinical-trial-study
#8
Alia Jalalodini, Manijeh Nourian, Kiarash Saatchi, Amir Kavousi, Mahnaz Ghaljeh
BACKGROUND: The outcomes of hospitalization anxiety are mental health disorders. One of the methods of anxiety reduction is massage, which can cause reduction of pain and changes in physiological parameters. OBJECTIVES: This study aimed to investigate the effects of slow-stroke back massage (SSBM) on hospitalization anxiety and physiological parameters in school-age children. METHODS: This clinical trial study included 80 school-aged children from Ali Ebne Abi Taleb hospital, located in Zahedan, who were selected using sequential sampling and randomly divided into two groups: a massage group (40) and a control group (40)...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28195646/ns1209-spd-502-a-novel-selective-ampa-antagonist-for-stroke-neuropathic-pain-or-epilepsy-drug-development-lessons-learned
#9
Jan M Keppel Hesselink
Preclinical Research The selective AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor antagonist, NS1209 (also known as SPD 502) has been explored in several research and development campaigns since its selection as a lead drug candidate in the early 1990s by the Danish biotechnology company, NeuroSearch. The compound was successively tested in animal models of stroke, neuropathic pain and epilepsy. The preclinical data to support development for the treatment of stroke were incomplete, as the compound was administered after the stroke episode, and did not protect subcortical areas of the brain...
February 13, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28192742/breast-cancer-detection-using-single-reading-of-breast-tomosynthesis-3d-mammography-compared-to-double-reading-of-2d-mammography-evidence-from-a-population-based-trial
#10
Nehmat Houssami, Daniela Bernardi, Marco Pellegrini, Marvi Valentini, Carmine Fantò, Livio Ostillio, Paolina Tuttobene, Andrea Luparia, Petra Macaskill
BACKGROUND: Most population breast cancer (BC) screening programs use double-reading of 2D-mammography. We recently reported the screening with tomosynthesis or standard mammography-2 (STORM-2) trial, showing that double-read tomosynthesis (pseudo-3D-mammography) detected more BC than double-read 2D-mammography. In this study, we compare screen-detection measures for single-reading of 3D-mammography with those for double-reading of 2D-mammography, to inform screening practice. METHODS: This is a secondary analysis based on STORM-2 which prospectively compared 3D-mammography and 2D-mammography in sequential screen-readings...
February 10, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28188612/hepatitis-b-immunoglobulin-during-pregnancy-for-prevention-of-mother-to-child-transmission-of-hepatitis-b-virus
#11
REVIEW
Ahizechukwu C Eke, George U Eleje, Uzoamaka A Eke, Yun Xia, Jiao Liu
BACKGROUND: Hepatitis is a viral infection of the liver. It is mainly transmitted between people through contact with infected blood, frequently from mother to baby in-utero. Hepatitis B poses significant risk to the fetus and up to 85% of infants infected by their mothers at birth develop chronic hepatitis B virus (HBV) infection. Hepatitis B immunoglobulin (HBIG) is a purified solution of human immunoglobulin that could be administered to the mother, newborn, or both. HBIG offers protection against HBV infection when administered to pregnant women who test positive for hepatitis B envelope antigen (HBeAg) or hepatitis B surface antigen (HBsAg), or both...
February 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28188529/dual-color-multiplex-analysis-of-protein-microarrays-for-precision-medicine
#12
Solomon Yeon, Florian Bell, Michael Shultz, Grace Lawrence, Michael Harpole, Virginia Espina
Generating molecular information in a clinically relevant time frame is the first hurdle to truly integrating precision medicine in health care. Reverse phase protein microarrays are being utilized in clinical trials for quantifying posttranslationally modified signal transduction proteins and cellular signaling pathways, allowing direct comparison of the activation state of proteins from multiple specimens, or individual patient specimens, within the same array. This technology provides diagnostic and therapeutic information critical to precision medicine...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28186942/use-of-combination-therapy-in-the-treatment-of-primary-osteoporosis-protocol-for-a-network-meta-analysis-of-randomised-trials
#13
Shenghan Lou, Houchen Lv, Yuxiang Chen, Licheng Zhang, Peifu Tang
INTRODUCTION: The existing medications approved for treatment of primary osteoporosis can be divided into antiresorptive drugs and anabolic drugs. According to the mechanisms of action, the combined therapy may produce a synergistic effect on bone mineral density (BMD) compared with monotherapy, and thus improves the efficacy of fracture resistance. This network meta-analysis aims to compare the efficacies of different combined methods for the treatment of primary osteoporosis. METHODS AND ANALYSIS: MEDLINE, EMBASE and Cochrane databases will be searched to identify all randomised controlled trials (RCTs) and quasi-RCTs that evaluate the effectiveness of combined therapy versus monotherapy for primary osteoporosis...
November 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/28181684/exercise-based-cardiac-rehabilitation-for-adults-with-atrial-fibrillation
#14
REVIEW
Signe S Risom, Ann-Dorthe Zwisler, Pernille P Johansen, Kirstine L Sibilitz, Jane Lindschou, Christian Gluud, Rod S Taylor, Jesper H Svendsen, Selina K Berg
BACKGROUND: Exercise-based cardiac rehabilitation may benefit adults with atrial fibrillation or those who had been treated for atrial fibrillation. Atrial fibrillation is caused by multiple micro re-entry circuits within the atrial tissue, which result in chaotic rapid activity in the atria. OBJECTIVES: To assess the benefits and harms of exercise-based rehabilitation programmes, alone or with another intervention, compared with no-exercise training controls in adults who currently have AF, or have been treated for AF...
February 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28178949/selective-serotonin-reuptake-inhibitors-versus-placebo-in-patients-with-major-depressive-disorder-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#15
Janus Christian Jakobsen, Kiran Kumar Katakam, Anne Schou, Signe Gade Hellmuth, Sandra Elkjær Stallknecht, Katja Leth-Møller, Maria Iversen, Marianne Bjørnø Banke, Iggiannguaq Juhl Petersen, Sarah Louise Klingenberg, Jesper Krogh, Sebastian Elgaard Ebert, Anne Timm, Jane Lindschou, Christian Gluud
BACKGROUND: The evidence on selective serotonin reuptake inhibitors (SSRIs) for major depressive disorder is unclear. METHODS: Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo, 'active' placebo, or no intervention in adult participants with major depressive disorder. We searched for eligible randomised clinical trials in The Cochrane Library's CENTRAL, PubMed, EMBASE, PsycLIT, PsycINFO, Science Citation Index Expanded, clinical trial registers of Europe and USA, websites of pharmaceutical companies, the U...
February 8, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28177921/axillary-staging-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy-in-two-dutch-phase-iii-studies
#16
Birgit E P J Vriens, Kristien B M I Keymeulen, Judith R Kroep, Ayoub Charehbili, Petronella G Peer, Maaike de Boer, Maureen J B Aarts, Esther M Heuts, Vivianne C G Tjan-Heijnen, The Dutch Breast Cancer Research Group Boog
BACKGROUND: Primary aim of our study was to assess the impact of timing of sentinel node procedure, pre- versus post-neoadjuvant chemotherapy, on final pathologic node-negative rate (pN0) in patients with clinically node-negative (cN0) breast cancer. Secondary endpoint was the usability of the sentinel node procedure in patients with clinically node-positive disease that converted to cN0 after neoadjuvant chemotherapy. PATIENTS AND METHODS: Patients were enrolled in two sequentially conducted Dutch phase III trials, studying the impact of two neoadjuvant chemotherapy schedules and use of zoledronic acid on complete pathologic response rate...
February 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28177897/comparison-between-transrectal-and-transperineal-prostate-biopsy-for-detection-of-prostate-cancer-a-meta-analysis-and-trial-sequential-analysis
#17
Jianxin Xue, Zhiqiang Qin, Hongzhou Cai, Chuanjie Zhang, Xiao Li, Weizhang Xu, Jingyuan Wang, Zicheng Xu, Bin Yu, Ting Xu, Qin Zou
To systematically assess the efficacy and complications of transrectal (TR) versus transperineal (TP) prostate biopsy in the detection of prostate cancer (PCa). A meta-analysis was performed by searching the databases Pubmed, Embase and Web of science for the relevant available studies until September 1st, 2016, and thirteen studies met the inclusion criteria. The pooled odds ratios with 95% confidence intervals were calculated to evaluate the differences of TR and TP groups in PCa detection rate. Then, trial sequential analysis was performed to reduce the risk of type I error and estimated whether the evidence of the results was reliable...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28174232/exposure-response-analysis-of-alvocidib-flavopiridol-treatment-by-bolus-or-hybrid-administration-in-newly-diagnosed-or-relapsed-refractory-acute-leukemia-patients
#18
Carl LaCerte, Vijay Deep Ivaturi, Jogarao Gobburu, Jacqueline M Greer, Austin Doyle, John J Wright, Judith Karp, Michelle A Rudek
PURPOSE: To elucidate any differences in the exposure-response of alvocidib (flavopiridol) given by 1 hour bolus or a hybrid schedule (30 minute bolus followed by a 4 hour infusion) using a flavopiridol/cytosine arabinoside/mitoxantrone sequential protocol (FLAM) in acute leukemia patients. The hybrid schedule was devised to be pharmacologically superior in chronic leukemia based on unbound exposure. EXPERIMENTAL DESIGN: Data from 129 patients in 3 FLAM studies were used for pharmacokinetic/pharmacodynamic modeling...
February 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28166457/sample-size-re-estimation-and-other-mid-course-adjustments-with-sequential-parallel-comparison-design
#19
Rachel K Silverman, Anastasia Ivanova
Sequential parallel comparison design (SPCD) was proposed to reduce placebo response in a randomized trial with placebo comparator. Subjects are randomized between placebo and drug in stage 1 of the trial and then placebo non-responders are re-randomized in stage 2. Efficacy analysis includes all data from stage 1 and all placebo non-responding subjects from stage 2. This article investigates the possibility to re-estimate the sample size and adjust the design parameters, allocation proportion to placebo in stage 1 of SPCD and weight of stage 1 data in the overall efficacy test statistic, during an interim analysis...
February 6, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28148534/single-visit-or-multiple-visit-root-canal-treatment-systematic-review-meta-analysis-and-trial-sequential-analysis
#20
Falk Schwendicke, Gerd Göstemeyer
OBJECTIVES: Single-visit root canal treatment has some advantages over conventional multivisit treatment, but might increase the risk of complications. We systematically evaluated the risk of complications after single-visit or multiple-visit root canal treatment using meta-analysis and trial-sequential analysis. DATA: Controlled trials comparing single-visit versus multiple-visit root canal treatment of permanent teeth were included. Trials needed to assess the risk of long-term complications (pain, infection, new/persisting/increasing periapical lesions ≥1 year after treatment), short-term pain or flare-up (acute exacerbation of initiation or continuation of root canal treatment)...
February 1, 2017: BMJ Open
keyword
keyword
118899
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"