keyword
https://read.qxmd.com/read/38534490/deep-learning-for-generalized-eeg-seizure-detection-after-hypoxia-ischemia-preclinical-validation
#1
JOURNAL ARTICLE
Hamid Abbasi, Joanne O Davidson, Simerdeep K Dhillon, Kelly Q Zhou, Guido Wassink, Alistair J Gunn, Laura Bennet
Brain maturity and many clinical treatments such as therapeutic hypothermia (TH) can significantly influence the morphology of neonatal EEG seizures after hypoxia-ischemia (HI), and so there is a need for generalized automatic seizure identification. This study validates efficacy of advanced deep-learning pattern classifiers based on a convolutional neural network (CNN) for seizure detection after HI in fetal sheep and determines the effects of maturation and brain cooling on their accuracy. The cohorts included HI-normothermia term ( n = 7), HI-hypothermia term ( n = 14), sham-normothermia term ( n = 5), and HI-normothermia preterm ( n = 14) groups, with a total of >17,300 h of recordings...
February 24, 2024: Bioengineering
https://read.qxmd.com/read/38522417/association-between-portal-vein-thrombosis-after-umbilical-vein-catheterization-and-neonatal-asphyxia
#2
JOURNAL ARTICLE
Marina Colella, Anna Zanin, Artemis Toumazi, Aurélie Bourmaud, Priscilla Boizeau, Sophie Guilmin-Crepon, Noémie Leick, Sophea Khat, Marianne Alison, Olivier Baud, Valerie Biran
INTRODUCTION: Neonatal portal vein thrombosis (PVT) is frequently related to umbilical venous catheterization (UVC), but risk factors remain unclear. This study aims to analyze the variables associated to PVT in near- to full-term newborns with UVC, with a focus on newborns exposed to controlled therapeutic hypothermia (CTH) for hypoxic ischemic encephalopathy (HIE). METHODS: This is retrospective cohort study of infants delivered at or after 36 weeks and with a birthweight over 1,500 g...
March 22, 2024: Neonatology
https://read.qxmd.com/read/38509202/urine-biomarkers-of-acute-kidney-injury-and-association-with-brain-mri-abnormalities-in-neonatal-hypoxic-ischemic-encephalopathy
#3
JOURNAL ARTICLE
Megan J Turner, Jennifer A Rumpel, Beverly J Spray, Nicholas Stence, Ilana Neuberger, Adam Frymoyer, Valerie Y Chock, Sherry Courtney, Katja Gist
OBJECTIVE: Determine whether urine biomarkers NGAL (neutrophil gelatinase-associated lipocalin), KIM-1 (kidney injury molecule 1) and IL-18 (interleukin-18) are associated with abnormal MRI findings in neonates with hypoxic-ischemic encephalopathy (HIE) who underwent therapeutic hypothermia (TH). STUDY DESIGN: Secondary analysis of a multicenter, prospective study of neonates with HIE requiring TH. Urine biomarkers were obtained at 12 and 24 h of life (HOL)...
March 20, 2024: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/38503980/quantitative-eeg-and-prediction-of-outcome-in-neonatal-encephalopathy-a-review
#4
REVIEW
Sriya Roychaudhuri, Katie Hannon, John Sunwoo, Aisling A Garvey, Mohamed El-Dib
Electroencephalogram (EEG) is an important biomarker for neonatal encephalopathy (NE) and has significant predictive value for brain injury and neurodevelopmental outcomes. Quantitative analysis of EEG involves the representation of complex EEG data in an objective, reproducible and scalable manner. Quantitative EEG (qEEG) can be derived from both a limited channel EEG (as available during amplitude integrated EEG) and multi-channel conventional EEG. It has the potential to enable bedside clinicians to monitor and evaluate details of cortical function without the necessity of continuous expert input...
March 19, 2024: Pediatric Research
https://read.qxmd.com/read/38492741/-neurodevelopment-and-neuroprotection-in-young-children
#5
JOURNAL ARTICLE
Stéphane Marret, Alexandra Chadie, Jean-Baptiste Muller, Clément Chollat
In France, the most pessimistic estimates put the prevalence of neurodevelopmental disorders (NDD) at 15% of births. The two largest populations of newborns at highest risk of NDD are premature babies and babies born into siblings with one or more infants who already have an autism spectrum disorder or another NDD. The high prevalence of these disorders justifies a health promotion policy, centred on the child and his or her family. Prevention is based on the early identification of high-risk factors, by informing families and training pregnancy and early childhood professionals, and implementing perinatal prevention protocols for high-risk newborns (antenatal corticosteroid therapy and magnesium sulfate for women at risk of preterm delivery before 32 weeks, developmental care, therapeutic hypothermia for full-term infants with early neonatal encephalopathy presumed to be anoxic)...
March 14, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
https://read.qxmd.com/read/38471802/intranasal-administration-of-bdnf-improves-recovery-and-promotes-neural-plasticity-in-a-neonatal-mouse-model-of-hypoxic-ischemia
#6
JOURNAL ARTICLE
Serena-Kaye Sims, Madelynne Saddow, Lilly McGonegal, Catrina Sims-Robinson
The benefit of intranasal brain derived neurotrophic factor (BDNF) treatment on cognitive function in a neonatal postnatal day 7 (P7) mouse model of hypoxic ischemia (HI) was explored. Intranasal delivery is attractive in that it can promote widespread distribution of BDNF within both the brain and spinal cord. In this study we evaluated the effectiveness of intranasal BDNF to improve cognitive recovery following HI. HI is induced via ligation of the right carotid artery followed by a 45-minute exposure to an 8% oxygen/ 92% nitrogen mixture in an enclosed chamber...
February 29, 2024: Experimental Neurobiology
https://read.qxmd.com/read/38468452/neonatal-magnesium-sulphate-for-neuroprotection-a-systematic-review-and-meta-analysis
#7
REVIEW
Emily Shepherd, Tasneem Karim, Sarah McIntyre, Shona Goldsmith, Amy Keir, Nadia Badawi, Rod W Hunt, Robert Galinsky
AIM: To review the evidence of the effects of neonatal magnesium sulphate for neuroprotection in perinatal asphyxia and hypoxic-ischaemic encephalopathy (HIE). METHOD: This was a systematic review of randomized controlled trials (RCTs) (with meta-analysis) and non-RCTs assessing magnesium sulphate for treating perinatal asphyxia and HIE at 35 weeks or more gestation (primary outcomes: neonatal death and death or long-term major neurodevelopmental disability)...
March 11, 2024: Developmental Medicine and Child Neurology
https://read.qxmd.com/read/38453562/neuroprotective-efficacy-of-hypothermia-and-inter-alpha-inhibitor-proteins-after-hypoxic-ischemic-brain-injury-in-neonatal-rats
#8
JOURNAL ARTICLE
Xiaodi F Chen, Yuqi Wu, Boram Kim, Kevin V Nguyen, Ainuo Chen, Joseph Qiu, Andre R Santoso, Clemence Disdier, Yow-Pin Lim, Barbara S Stonestreet
Therapeutic hypothermia is the standard of care for hypoxic-ischemic (HI) encephalopathy. Inter-alpha Inhibitor Proteins (IAIPs) attenuate brain injury after HI in neonatal rats. Human (h) IAIPs (60 ​mg/kg) or placebo (PL) were given 15 ​min, 24 and 48 ​h to postnatal (P) day-7 rats after carotid ligation and 8% oxygen for 90 ​min with (30 ​°C) and without (36 ​°C) exposure to hypothermia 1.5 ​h after HI for 3 ​h...
March 6, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38450797/population-pharmacokinetics-of-vancomycin-in-term-neonates-with-perinatal-asphyxia-treated-with-therapeutic-hypothermia
#9
JOURNAL ARTICLE
Marlotte A A van der Veer, Timo R de Haan, Linda G W Franken, Reinier M van Hest, Floris Groenendaal, Peter H Dijk, Willem P de Boode, Sinno Simons, Koen P Dijkman, Henrica L M van Straaten, Monique Rijken, Filip Cools, Debbie H G M Nuytemans, Anton H van Kaam, Yuma A Bijleveld, Ron A A Mathôt
AIMS: Little is known about the population pharmacokinetics (PPK) of vancomycin in neonates with perinatal asphyxia treated with therapeutic hypothermia (TH). We aimed to describe the PPK of vancomycin and propose an initial dosing regimen for the first 48 h of treatment with pharmacokinetic/pharmacodynamic target attainment. METHODS: Neonates with perinatal asphyxia treated with TH were included from birth until Day 6 in a multicentre prospective cohort study...
March 7, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38442509/subcutaneous-fat-necrosis-of-the-newborn-a-systematic-review-of-surgical-management-and-outcomes
#10
REVIEW
Eric Bao, Dillan F Villavisanis, Taylor J Ibelli, Lior Levy, Peter J Taub
BACKGROUND: Subcutaneous fat necrosis of the newborn (SCFN) is a rare form of panniculitis manifesting as erythematous plaques or nodules at sites of brown fat in neonates. Surgical management may be indicated in severe cases; however, there is a paucity of literature compiling presentations and outcomes of these surgical patients. METHODS: The authors performed a systematic review, in consultation with a licensed librarian, on MEDLINE and Embase for studies including patients with SCFN who were surgically managed...
February 15, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38442443/plasmatic-profiles-of-cytokines-chemokines-glial-fibrillary-acidic-protein-gfap-and-mri-brain-damage-in-neonates-with-hypoxic-ischemic-encephalopathy-hie
#11
JOURNAL ARTICLE
Cinzia Auriti, Vito Mondì, Fiammetta Piersigilli, Laura Timelli, Tamara Del Pinto, Giusi Prencipe, Giulia Lucignani, Daniela Longo, Iliana Bersani
BACKGROUND: Perinatal hypoxia triggers the release of cytokines and chemokines by neurons, astrocytes and microglia. In response to hypoxia-ischemia resting/ramified microglia proliferate and undergo activation, producing proinflammatory molecules. The brain damage extension seems to be related to both the severity of hypoxia and the balance between pro and anti-inflammatory response and can be explored with neuroimaging. AIMS: The aim of this preliminary study was to explore possible relationships between plasma levels of inflammatory cytokines/chemokines and the severe brain damage detectable by Magnetic Resonance Imaging (MRI), performed during the hospitalization...
May 2024: Cytokine
https://read.qxmd.com/read/38440801/socioemotional-and-psychological-outcomes-of-hypoxic-ischemic-encephalopathy-a-systematic-review
#12
JOURNAL ARTICLE
Grace H Kromm, Hilary Patankar, Shubang Nagalotimath, Hilary Wong, Topun Austin
BACKGROUND AND OBJECTIVES: Therapeutic hypothermia has reduced the risk of death or major disability following perinatal hypoxic-ischemic encephalopathy (HIE); however, many children who experience perinatal HIE still go on to develop personal and behavioral challenges, which can be difficult for caregivers and a public health burden for society. Our objective with this review is to systematically identify and synthesize studies that evaluate associations between perinatal HIE and socioemotional or psychological outcomes...
March 5, 2024: Pediatrics
https://read.qxmd.com/read/38438129/nutrition-of-newborns-with-hypoxic-ischaemic-encephalopathy-during-therapeutic-hypothermia-a-survey-of-practice-in-polish-neonatal-care-units
#13
JOURNAL ARTICLE
Aleksandra Warchoł, Przemko Kwinta
BACKGROUND: The nutritional practice for newborns with hypoxic-ischaemic encephalopathy during therapeutic hypothermia differs among Polish neonatal care units, as no guidelines are provided. We assessed the prevailing procedures. MATERIAL AND METHODS: Data was collected through an anonymous, web-based questionnaire. We surveyed aspects of the current nutritional practices and the reasoning behind the choice of the feeding strategy. RESULTS: Thirty-one responses were obtained (31/33, 94%)...
February 1, 2024: Journal of mother and child
https://read.qxmd.com/read/38428637/-investigation-of-a-french-cohort-of-neonatal-anoxo-ischemic-encephalopathy-in-the-era-of-therapeutic-hypothermia-questions-and-answers
#14
JOURNAL ARTICLE
Thierry Debillon, Jonathan Beck, Isabelle Guellec, Antoine Vilotitch, Véronique Pierrat, Olivier Baud, Loïc Sentilhes, Gilles Kayem, Anne Ego
OBJECTIVE: to improve knowledge of Neonatal Hypoxic-Ischemic Encephalopathy, a prospective, nationwide, population-based cohort of affected children is being set up between September 2015 and March 2017. METHODS: during this period, 794 cases are collected, with information on pregnancy, delivery, neonatal stay and outcome at the end of hospitalization. Clinical and parental questionnaire follow-up is planned until the child is 4 years old. RESULTS: this article presents the clinical presentation of the newborns included, the analysis of factors associated with short-term outcome at hospital discharge and the organizational factors associated with treatment with Therapeutic Hypothermia...
February 28, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
https://read.qxmd.com/read/38424232/standardizing-neonatal-hypoxic-ischemic-encephalopathy-evaluation-and-documentation-practices
#15
JOURNAL ARTICLE
Patrick J Peebles, Lori Christ, John Flibotte, Liandra Presser, Leah H Carr
BACKGROUND: Infants at risk for hypoxic ischemic encephalopathy (HIE) require a time sensitive evaluation and decision-making regarding treatment with therapeutic hypothermia (TH). Prior to this project, there was no standardized approach to evaluating these infants locally. METHODS: Included infants were "at risk for HIE," defined as meeting the "patient characteristics" and "biochemical criteria" per the institutional HIE pathway. Our primary outcome was documentation of an HIE therapeutic hypothermia evaluation (HIETHE) within the first six hours of life which included: (1) recognition of at-risk status, (2) an encephalopathy exam, and (3) a decision regarding TH...
February 29, 2024: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/38422458/risk-factors-and-outcomes-for-cerebral-palsy-with-hypoxic-ischemic-brain-injury-patterns-without-documented-neonatal-encephalopathy
#16
JOURNAL ARTICLE
Olivier Fortin, Nafisa Husein, Maryam Oskoui, Michael I Shevell, Adam Kirton, Mary Dunbar
BACKGROUND AND OBJECTIVES: Perinatal hypoxic-ischemic brain injury is a leading cause of term-born cerebral palsy, the most common lifelong physical disability. Diagnosis is commonly made in the neonatal period by the combination of neonatal encephalopathy (NE) and typical neuroimaging findings. However, children without a history of neonatal encephalopathy may present later in childhood with motor disability and neuroimaging findings consistent with perinatal hypoxic-ischemic injury...
March 26, 2024: Neurology
https://read.qxmd.com/read/38388007/therapeutic-hypothermia-after-perinatal-asphyxia-in-vietnam-medium-term-outcomes-at-18-months-a-prospective-cohort-study
#17
JOURNAL ARTICLE
Hang Thi Thanh Tran, Ha Thi Le, Dien Minh Tran, Giang Thi Huong Nguyen, Lena Hellström-Westas, Tobias Alfven, Linus Olson
AIM: To determine neurodevelopmental outcome at 18 months after therapeutic hypothermia for hypoxic-ischaemic encephalopathy (HIE) infants in Vietnam, a low-middle-income country. METHOD: Prospective cohort study investigating outcomes at 18 months in severely asphyxiated outborn infants who underwent therapeutic hypothermia for HIE in Hanoi, Vietnam, during the time period 2016-2019. Survivors were examined at discharge and at 6 and 18 months by a neonatologist, a neurologist and a rehabilitation physician, who were blinded to the infants' clinical severity during hospitalisation using two assessment tools: the Ages and Stages Questionnaire (ASQ) and the Hammersmith Infant Neurological Examination (HINE), to detect impairments and promote early interventions for those who require it...
February 21, 2024: BMJ Paediatrics Open
https://read.qxmd.com/read/38386136/rbm3-promotes-anti-inflammatory-responses-in-microglia-and-serves-as-a-neuroprotective-target-of-ischemic-stroke
#18
JOURNAL ARTICLE
Junyi Zhao, Siyu Liu, Kunyu Li, Yulu Yang, Yue Zhao, Xinzhou Zhu
Ischemic stroke is a major cause of death and disability in adults. Hypothermic treatment is successful in treating neonatal cerebral ischemia, but its application is restricted in adult patients due to complex management strategies and severe adverse effects. Two homologous RNA-binding proteins, RBM3 and CIRP, are the only known cold-inducible proteins in vertebrates, and their expression levels are robustly elevated by mild to moderate hypothermia. In previous studies, we and others have demonstrated that both RBM3 and CIRP mediate the neuroprotective and neurogenic effects of hypothermia in cell and animal models...
February 22, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38375125/hypoxic-ischemic-encephalopathy-indicators-of-sarnat-and-sarnat-scoring-in-neonatal-subjects-with-perinatal-asphyxia
#19
JOURNAL ARTICLE
Parvaneh Sadeghi Moghaddam, Mohammad Aghaali, Seyede Zeinab Modarresy, Samira Shahhamzei, Maryam Aljaboori
OBJECTIVES: Hypoxic-ischemic encephalopathy (HIE) is still a relevant cause of neonatal mortality and morbidity. HIE severity can predict long-term outcomes. Sarnat staging is one of the most common methods used to evaluate HIE severity. However, an ongoing urge exists to find other accurate and affordable ways to accompany this clinical staging for HIE. This study aimed to evaluate the relationship between cerebral arteries' resistive indices and other hypoxic-ischemic encephalopathy indicators using Sarnat scoring of newborns subjected to perinatal asphyxia...
2024: Iranian Journal of Child Neurology
https://read.qxmd.com/read/38369239/racial-and-ethnic-inequities-in-therapeutic-hypothermia-and-neonatal-hypoxic-ischemic-encephalopathy-a-retrospective-cohort-study
#20
JOURNAL ARTICLE
Carolyn Fall, Rebecca J Baer, Laura Jelliffe-Pawlowski, Nana Matoba, Henry C Lee, Christina D Chambers, Gretchen Bandoli
OBJECTIVE: To investigate racial inequities in the use of therapeutic hypothermia (TH) and outcomes in infants with hypoxic ischemic encephalopathy (HIE). STUDY DESIGN: We queried an administrative birth cohort of mother-baby pairs in California from 2010 through 2019 using ICD codes to evaluate the association between race and ethnicity and the application of TH in infants with HIE. We identified 4,779 infants with HIE. Log-linear regression was used to calculate risk ratios (RR) for TH, adjusting for hospital transfer, rural location, gestational age between 35 and 37 weeks, and HIE severity...
February 16, 2024: Journal of Pediatrics
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