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Kossmann Robert

Kamyar Kalantar-Zadeh, Vidhya Parameswaran, Linda H Ficociello, Ludmila Anderson, Norma J Ofsthun, Christopher Kwoh, Claudy Mullon, Robert J Kossmann, Daniel W Coyne
BACKGROUND: A database analysis was conducted to assess the effectiveness of sucroferric oxyhydroxide (SO) on lowering serum phosphorus and phosphate binder (PB) pill burden among adult peritoneal dialysis (PD) patients prescribed SO as part of routine care. METHODS: Adult PD patients (n = 258) prescribed SO through a renal pharmacy service were analyzed. Baseline was 3 months before SO prescription. SO-treated follow-up was for 6 months or until either a new PB was prescribed, SO was not refilled, PD modality changed, or patient was discharged...
2018: American Journal of Nephrology
Brent W Miller, Rainer Himmele, Dixie-Ann Sawin, Jeeseon Kim, Robert J Kossmann
BACKGROUND/AIM: Home hemodialysis (HHD) has been associated with improved clinical outcomes vs. in-center HD (ICHD). The prevalence of HHD in the United States is still very low at 1.8%. This critical review compares HHD and ICHD outcomes for survival, hospitalization, cardiovascular (CV), nutrition, and quality of life (QoL). METHODS: Of 545 publications identified, 44 were not selected after applying exclusion criteria. A systematic review of the identified publications was conducted to compare HHD to ICHD outcomes for survival, hospitalization, CV outcomes, nutrition, and QoL...
2018: Blood Purification
Shakil Aslam, Subodh J Saggi, Moro Salifu, Robert J Kossmann
Dialysis dose is an important determinant of clinical outcomes in patients with end stage renal disease on maintenance dialysis. In clinical practice dialysis dose is monitored at least monthly by urea clearance based on Urea Kinetic Modeling. Online clearance monitoring using effective ionic dialysance (EID) of sodium (Na+ ) is available on some hemodialysis machines. This paper reviews the background, methodology, additional applications, and potential risks associated with EID. Effective ionic dialysance provides a reliable, real-time, noninvasive, and inexpensive measurement of dialysis dose during an ongoing hemodialysis (HD) session to allow interventions and assess the impact of these changes on clearance...
December 6, 2017: Hemodialysis International
Daniel W Coyne, Linda H Ficociello, Vidhya Parameswaran, Ludmila Anderson, Sharanya Vemula, Norma J Ofsthun, Claudy Mullon, Franklin W Maddux, Robert J Kossmann, Stuart M Sprague
AIMS: Hyperphosphatemia has been associated with an increased risk of mortality in patients with end-stage renal disease. We sought to assess the real-world effectiveness of sucroferric oxyhydroxide (SO), an iron-based phosphate binder (PB), in control of serum phosphorus levels, and to determine the associated pill burden in hemodialysis patients. MATERIALS AND METHODS: Adult, in-center hemodialysis patients first prescribed SO through a renal pharmacy service as part of routine clinical care between April 1, 2014 and March 31, 2015 were included in the analysis...
August 2017: Clinical Nephrology
Shakil Aslam, Robert J Kossmann
No abstract text is available yet for this article.
March 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Blaine R Roberts, Dominic J Hare, Catriona A McLean, Alison Conquest, Monica Lind, Qiao-Xin Li, Ashley I Bush, Colin L Masters, Maria-Christina Morganti-Kossmann, Tony Frugier
Traumatic brain injury (TBI) is the most common cause of death and disability in young adults, yet the molecular mechanisms that follow TBI are poorly understood. We previously reported a perturbation in iron (Fe) levels following TBI. Here we report that the distribution of cobalt (Co) is modulated in post-mortem human brain following injury. We also investigated how the distribution of other biologically relevant elements changes in TBI. Cobalt is increased due to TBI while copper (Cu), magnesium (Mg), manganese (Mn), phosphorus (P), potassium (K), rubidium (Rb), selenium (Se) and zinc (Zn) remain unchanged...
January 2015: Metallomics: Integrated Biometal Science
Peter J Crack, Moses Zhang, Maria Cristina Morganti-Kossmann, Andrew J Morris, Jonathan M Wojciak, Jonathan K Fleming, Ila Karve, David Wright, Maithili Sashindranath, Yona Goldshmit, Alison Conquest, Maria Daglas, Leigh A Johnston, Robert L Medcalf, Roger A Sabbadini, Alice Pébay
BACKGROUND: Lysophosphatidic acid (LPA) is a bioactive phospholipid with a potentially causative role in neurotrauma. Blocking LPA signaling with the LPA-directed monoclonal antibody B3/Lpathomab is neuroprotective in the mouse spinal cord following injury. FINDINGS: Here we investigated the use of this agent in treatment of secondary brain damage consequent to traumatic brain injury (TBI). LPA was elevated in cerebrospinal fluid (CSF) of patients with TBI compared to controls...
February 27, 2014: Journal of Neuroinflammation
Christopher P Larsen, Robert J Kossmann, Marjorie L Beggs, Alan Solomon, Patrick D Walker
Leukocyte chemotactic factor 2 amyloidosis (ALECT2) is a recently described form of amyloidosis that most frequently manifests clinically with progressive renal failure. In a series of 414 cases of amyloidosis, there were 40 cases of ALECT2: the second most common type of renal amyloidosis in this series. This was particularly common in Hispanic patients in the Southwest United States, where more than half of amyloidosis cases were ALECT2. It is possible that this represents a familial amyloidosis as there were two brothers with ALECT2 in our study...
August 2014: Kidney International
Robert J Kossmann
My service within the RPA began with my need to be a part of the solution, to help navigate the direction of inevitable change, and to ensure we do not lose focus of our ultimate goal as nephrologists-the provision of excellent kidney care. I would encourage all of you to participate in this process as well. It is essential that we maintain our independence, ethics and principals, and excellence in our roles and responsibilities as nephrologists and dialysis unit medical directors, especially in challenging times such as these...
October 2013: Nephrology News & Issues
Stephan Thijssen, Robert J Kossmann, Anja Kruse, Peter Kotanko
BACKGROUND/AIM: Citrate anticoagulation in hemodialysis (HD) is increasingly drawing attention in the nephrology community. One of the major deterrents to a more widespread use are the monitoring requirements for fear of systemic calcium derangements. Means of accurately predicting systemic ionized calcium (iCa) may help to overcome this challenge. We have previously presented a mathematical model of regional citrate anticoagulation (RCA) to address this need. Here, we present a refined model and show results in an independent validation cohort of maintenance HD patients on Citrasate®, a calcium- and citrate-containing dialysate...
2013: Blood Purification
Maithili Sashindranath, Eunice Sales, Maria Daglas, Roxann Freeman, Andre L Samson, Elisa J Cops, Simone Beckham, Adam Galle, Catriona McLean, Cristina Morganti-Kossmann, Jeffrey V Rosenfeld, Rime Madani, Jean-Dominique Vassalli, Enming J Su, Daniel A Lawrence, Robert L Medcalf
The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is a serine protease that converts plasminogen to plasmin, a protease that dissolves blood clots. Besides its role in fibrinolysis, tissue plasminogen activator is abundantly expressed in the brain where it mediates extracellular proteolysis. However, proteolytically active tissue plasminogen activator also promotes neurovascular disruption after ischaemic stroke; the molecular mechanisms of this process are still unclear...
November 2012: Brain: a Journal of Neurology
Matthias Oelze, Maike Knorr, Swenja Kröller-Schön, Sabine Kossmann, Anna Gottschlich, Robert Rümmler, Alexandra Schuff, Steffen Daub, Christopher Doppler, Hartmut Kleinert, Tommaso Gori, Andreas Daiber, Thomas Münzel
AIMS: Isosorbide-5-mononitrate (ISMN) is one of the most frequently used compounds in the treatment of coronary artery disease predominantly in the USA. However, ISMN was reported to induce endothelial dysfunction, which was corrected by vitamin C pointing to a crucial role of reactive oxygen species (ROS) in causing this phenomenon. We sought to elucidate the mechanism how ISMN causes endothelial dysfunction and oxidative stress in vascular tissue. METHODS AND RESULTS: Male Wistar rats (n= 69 in total) were treated with ISMN (75 mg/kg/day) or placebo for 7 days...
November 2013: European Heart Journal
Robert Jan Kossmann
Transitions in levels of health offer important opportunities to affect patient outcomes. The transition from CKD to ESRD and dialysis dependence is costly in personal, social, and economic terms. This paper reviews these costs and offers resources that can be used by physicians and medical teams to help patients and their families weather the challenges of this process.
November 2011: Advances in Chronic Kidney Disease
Robert J Kossmann, Annette Gonzales, Robin Callan, Suhail Ahmad
BACKGROUND AND OBJECTIVES: A bicarbonate dialysate acidified with citrate (CD) has been reported to have local anticoagulant effect. This study examines the effect of CD on dialysis efficiency, measured as eKt/Vurea, and predialysis concentrations of BUN, creatinine, phosphate, and beta-2 microglobulin in chronic dialysis units. DESIGN, SETTINGS, PARTICIPANTS, & MEASUREMENTS: Three outpatient chronic hemodialysis units with 142 patients were switched to CD for 6 mo...
September 2009: Clinical Journal of the American Society of Nephrology: CJASN
C E Kossmann
No abstract text is available yet for this article.
September 1963: Bulletin of the New York Academy of Medicine
Robert J Kossmann, Suhail Ahmad
No abstract text is available yet for this article.
June 2008: Nephrology News & Issues
Kenneth Heng, Adam Bystrzycki, Mark Fitzgerald, Robert Gocentas, Stephen Bernard, Louise Niggemeyer, David James Cooper, Thomas Kossmann
BACKGROUND: The purpose of the present study was to determine the complication rates associated with intercostal catheter insertion (ICI) performed using Early Management of Severe Trauma (EMST) guidelines on trauma patients admitted through The Alfred Trauma Centre. METHODS: The Alfred Trauma Registry identified demographic and clinical data for patients who underwent ICI in the Alfred hospital following admission for trauma. The medical histories were subsequently reviewed for complications resulting from ICI...
June 2004: ANZ Journal of Surgery
Christopher J Hewitt, Robert Franke, Achim Marx, Beate Kossmann, Peter Ottersbach
Fluorescent staining techniques were used to study the anti-microbial properties of aqueous suspensions of a novel, water insoluble amino functionalised polymer on three micro-organisms Pseudomonas fluorescens, Staphylococcus epidermidis and Saccharomyses cerevisiae. The mechanism of action was similar for each organism in that, after various contact times with the polymer, a progressive change in individual cell physiological state was measured using multi-parameter flow cytometry. The microbiocidal activity of this polymer may be similar to that of substances referred to as polycationic, amphipathic compounds (peptides, peptide derivatives and other polyamines)...
April 2004: Biotechnology Letters
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