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https://www.readbyqxmd.com/read/28267923/multifunctional-cellulolytic-enzymes-outperform-processive-fungal-cellulases-for-coproduction-of-nanocellulose-and-biofuels
#1
John M Yarbrough, Ruoran Zhang, Ashutosh Mittal, Todd Vander Wall, Yannick J Bomble, Stephen R Decker, Michael E Himmel, Peter N Ciesielski
Producing fuels, chemicals, and materials from renewable resources to meet societal demands remains an important step in the transition to a sustainable, clean energy economy. The use of cellulolytic enzymes for the production of nanocellulose enables the coproduction of sugars for biofuels production in a format that is largely compatible with the process design employed by modern lignocellulosic (second generation) biorefineries. However, yields of enzymatically produced nanocellulose are typically much lower than those achieved by mineral acid production methods...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28267425/book-review-atlas-of-histology-of-the-juvenile-rat-atlas-of-histology-of-the-juvenile-rat-parker-george-a-picut-catherine-a-editors-academic-press-elsevier-cambridge-ma-2016-150-hardcover-or-ebook-isbn-978-0-12-802682-3
#2
https://www.readbyqxmd.com/read/28262664/motor-neurons-control-blood-vessel-patterning-in-the-developing-spinal-cord
#3
Patricia Himmels, Isidora Paredes, Heike Adler, Andromachi Karakatsani, Robert Luck, Hugo H Marti, Olga Ermakova, Eugen Rempel, Esther T Stoeckli, Carmen Ruiz de Almodóvar
Formation of a precise vascular network within the central nervous system is of critical importance to assure delivery of oxygen and nutrients and for accurate functionality of neuronal networks. Vascularization of the spinal cord is a highly stereotypical process. However, the guidance cues controlling blood vessel patterning in this organ remain largely unknown. Here we describe a new neuro-vascular communication mechanism that controls vessel guidance in the developing spinal cord. We show that motor neuron columns remain avascular during a developmental time window, despite expressing high levels of the pro-angiogenic vascular endothelial growth factor (VEGF)...
March 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28251275/-patient-experiences-and-patient-centeredness-the-website-project-dipex-germany
#4
Martina Breuning, Gabriele Lucius-Hoene, Christina Burbaum, Wolfgang Himmel, Jürgen Bengel
Patient centeredness is a central concept in the treatment and rehabilitation of persons with chronic illness in Germany. There are various concepts of and approaches to patient centeredness, most of them developed from the perspective of health care research and the institutions. In terms of participation requirements, there has been a lack of understanding of the patient's perspective and experiences so far. In this article, the authors assume that the collection and analysis of patient experiences can improve patient participation and provide access to the experience of living and coping with an illness, including the patient's interactions with the health care system, their participation, and their preferences for participation...
March 1, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28245366/book-review-atlas-of-histology-of-the-juvenile-rat-atlas-of-histology-of-the-juvenile-rat-parker-george-a-picut-catherine-a-editors-academic-press-elsevier-cambridge-ma-2016-150-hardcover-or-ebook-isbn-978-0-12-802682-3
#5
https://www.readbyqxmd.com/read/28218800/hydrogen-atom-transfer-hat-initiated-by-intramolecular-ligand-metal-electron-transfer
#6
Hendrik Herrmann, Elisabeth Kaifer, Hans-Jörg Himmel
Hydrogen-atom transfer (HAT) is of key importance for several catalytic and biological processes, and provides an elegant access to C-H activation. In synthetic chemistry, a photoactivated metal complex is often employed to abstract an oxygen- or nitrogen-bound hydrogen, and the as-generated oxygen- or nitrogen-centered radical is the hydrogen-atom acceptor for HAT. Here, we report the first examples for HAT processes initiated by one-electron oxidation of urea azines. A further novelty is that the HAT-initiating oxidation can be realized by intramolecular ligand-metal electron transfer in copper(II)-urea azine complexes...
April 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28211142/a-stable-hexakis-guanidino-benzene-realization-of-the-strongest-neutral-organic-four-electron-donor
#7
Benjamin Eberle, Elisabeth Kaifer, Hans-Jörg Himmel
The growing demand for efficient batteries has stimulated the search for redox-active organic compounds with multistage redox behavior, as materials with large charge capacity. Herein we report the synthesis and properties of the first hexakis(guanidino)benzene derivative: a strong neutral organic electron donor with reversible multistage redox behavior and a record low redox potential for donation of four electrons. Detailed structural and spectroscopic characterization of three redox states (0, +2, and +4) reveal its unique electronic features...
March 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28207378/book-review-atlas-of-histology-of-the-juvenile-rat-atlas-of-histology-of-the-juvenile-rat-parker-george-a-picut-catherine-a-editors-academic-press-elsevier-cambridge-ma-2016-150-hardcover-or-ebook-isbn-978-0-12-802682-3
#8
https://www.readbyqxmd.com/read/28191844/armsd-a-comprehensive-tool-for-structural-analysis
#9
Arne Wagner, Hans-Jörg Himmel
A new free tool for structural comparison is presented that combines existing and new features into a single software package. aRMSD incorporates the functions of establishing a pairwise correlation between the atoms of two molecular structures and the calculation of the optimal rotation matrix that minimizes the root-mean-square deviation (RMSD) between the molecules. The complexity of the Hungarian assignation problem is reduced by decomposing molecules into different subsets based on different atom or group types allowing for an efficient and robust treatment of large molecules while tolerating different substituents...
February 27, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28184247/a-versatile-2a-peptide-based-bicistronic-protein-expressing-platform-for-the-industrial-cellulase-producing-fungus-trichoderma-reesei
#10
Venkataramanan Subramanian, Logan A Schuster, Kyle T Moore, Larry E Taylor, John O Baker, Todd A Vander Wall, Jeffrey G Linger, Michael E Himmel, Stephen R Decker
BACKGROUND: The industrial workhorse fungus, Trichoderma reesei, is typically exploited for its ability to produce cellulase enzymes, whereas use of this fungus for over-expression of other proteins (homologous and heterologous) is still very limited. Identifying transformants expressing target protein is a tedious task due to low transformation efficiency, combined with highly variable expression levels between transformants. Routine methods for identification include PCR-based analysis, western blotting, or crude activity screening, all of which are time-consuming techniques...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28019666/engineering-the-n-terminal-end-of-cela-results-in-improved-performance-and-growth-of-caldicellulosiruptor-bescii-on-crystalline-cellulose
#11
Sun-Ki Kim, Daehwan Chung, Michael E Himmel, Yannick J Bomble, Janet Westpheling
CelA is the most abundant enzyme secreted by Caldicellulosiruptor bescii and has been shown to outperform mixtures of commercially available exo- and endoglucanases in vitro. CelA contains both a glycoside hydrolase family 9 endoglucanase and a glycoside hydrolase family 48 exoglucanase known to be synergistic in their activity, connected by three cellulose-binding domains via linker peptides. Here, repeated aspartate residues were introduced into the N-terminal ends of CelA GH9 and GH48 domains to improve secretion efficiency and/or catalytic efficiency of CelA...
May 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28001108/pathology-in-practice
#12
Lauren E Himmel, Rachel B Song, Ronaldo C da Costa, Michael J Oglesbee
No abstract text is available yet for this article.
January 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27895710/in-situ-label-free-imaging-of-hemicellulose-in-plant-cell-walls-using-stimulated-raman-scattering-microscopy
#13
Yining Zeng, John M Yarbrough, Ashutosh Mittal, Melvin P Tucker, Todd B Vinzant, Stephen R Decker, Michael E Himmel
BACKGROUND: Plant hemicellulose (largely xylan) is an excellent feedstock for renewable energy production and second only to cellulose in abundance. Beyond a source of fermentable sugars, xylan constitutes a critical polymer in the plant cell wall, where its precise role in wall assembly, maturation, and deconstruction remains primarily hypothetical. Effective detection of xylan, particularly by in situ imaging of xylan in the presence of other biopolymers, would provide critical information for tackling the challenges of understanding the assembly and enhancing the liberation of xylan from plant materials...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27881519/comparison-of-therapy-persistence-for-fixed-versus-free-combination-antihypertensives-a-retrospective-cohort-study
#14
Thomas Grimmsmann, Wolfgang Himmel
OBJECTIVES: The aim of the study was to compare therapy persistence among patients who started with one of three drug regimens: a monotherapy, or combination therapy either as a fixed combination (ie, 'single pill') or as a free combination (ie, two separate antihypertensive agents). DESIGN: In a secondary data analysis, we used descriptive statistics and multivariate logistic regression to measure the effect of the three therapy regimens on therapy persistence over 4 years...
November 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/27858422/measurement-of-coherent-%C3%AF-production-in-low-energy-neutrino-carbon-scattering
#15
K Abe, C Andreopoulos, M Antonova, S Aoki, A Ariga, S Assylbekov, D Autiero, S Ban, M Barbi, G J Barker, G Barr, P Bartet-Friburg, M Batkiewicz, F Bay, V Berardi, S Berkman, S Bhadra, A Blondel, S Bolognesi, S Bordoni, S B Boyd, D Brailsford, A Bravar, C Bronner, M Buizza Avanzini, R G Calland, T Campbell, S Cao, J Caravaca Rodríguez, S L Cartwright, R Castillo, M G Catanesi, A Cervera, D Cherdack, N Chikuma, G Christodoulou, A Clifton, J Coleman, G Collazuol, D Coplowe, L Cremonesi, A Dabrowska, G De Rosa, T Dealtry, P F Denner, S R Dennis, C Densham, D Dewhurst, F Di Lodovico, S Di Luise, S Dolan, O Drapier, K E Duffy, J Dumarchez, S Dytman, M Dziewiecki, S Emery-Schrenk, A Ereditato, T Feusels, A J Finch, G A Fiorentini, M Friend, Y Fujii, D Fukuda, Y Fukuda, A P Furmanski, V Galymov, A Garcia, S G Giffin, C Giganti, F Gizzarelli, M Gonin, N Grant, D R Hadley, L Haegel, M D Haigh, P Hamilton, D Hansen, J Harada, T Hara, M Hartz, T Hasegawa, N C Hastings, T Hayashino, Y Hayato, R L Helmer, M Hierholzer, A Hillairet, A Himmel, T Hiraki, S Hirota, M Hogan, J Holeczek, S Horikawa, F Hosomi, K Huang, A K Ichikawa, K Ieki, M Ikeda, J Imber, J Insler, R A Intonti, T J Irvine, T Ishida, T Ishii, E Iwai, K Iwamoto, A Izmaylov, A Jacob, B Jamieson, M Jiang, S Johnson, J H Jo, P Jonsson, C K Jung, M Kabirnezhad, A C Kaboth, T Kajita, H Kakuno, J Kameda, D Karlen, I Karpikov, T Katori, E Kearns, M Khabibullin, A Khotjantsev, D Kielczewska, T Kikawa, H Kim, J Kim, S King, J Kisiel, A Knight, A Knox, T Kobayashi, L Koch, T Koga, A Konaka, K Kondo, A Kopylov, L L Kormos, A Korzenev, Y Koshio, W Kropp, Y Kudenko, R Kurjata, T Kutter, J Lagoda, I Lamont, E Larkin, P Lasorak, M Laveder, M Lawe, M Lazos, T Lindner, Z J Liptak, R P Litchfield, X Li, A Longhin, J P Lopez, L Ludovici, X Lu, L Magaletti, K Mahn, M Malek, S Manly, A D Marino, J Marteau, J F Martin, P Martins, S Martynenko, T Maruyama, V Matveev, K Mavrokoridis, W Y Ma, E Mazzucato, M McCarthy, N McCauley, K S McFarland, C McGrew, A Mefodiev, C Metelko, M Mezzetto, P Mijakowski, A Minamino, O Mineev, S Mine, A Missert, M Miura, S Moriyama, Th A Mueller, S Murphy, J Myslik, T Nakadaira, M Nakahata, K G Nakamura, K Nakamura, K D Nakamura, S Nakayama, T Nakaya, K Nakayoshi, C Nantais, C Nielsen, M Nirkko, K Nishikawa, Y Nishimura, P Novella, J Nowak, H M O'Keeffe, R Ohta, K Okumura, T Okusawa, W Oryszczak, S M Oser, T Ovsyannikova, R A Owen, Y Oyama, V Palladino, J L Palomino, V Paolone, N D Patel, M Pavin, D Payne, J D Perkin, Y Petrov, L Pickard, L Pickering, E S Pinzon Guerra, C Pistillo, B Popov, M Posiadala-Zezula, J-M Poutissou, R Poutissou, P Przewlocki, B Quilain, T Radermacher, E Radicioni, P N Ratoff, M Ravonel, M A M Rayner, A Redij, E Reinherz-Aronis, C Riccio, P Rojas, E Rondio, S Roth, A Rubbia, A Rychter, R Sacco, K Sakashita, F Sánchez, F Sato, E Scantamburlo, K Scholberg, S Schoppmann, J Schwehr, M Scott, Y Seiya, T Sekiguchi, H Sekiya, D Sgalaberna, R Shah, A Shaikhiev, F Shaker, D Shaw, M Shiozawa, T Shirahige, S Short, M Smy, J T Sobczyk, H Sobel, M Sorel, L Southwell, P Stamoulis, J Steinmann, T Stewart, P Stowell, Y Suda, S Suvorov, A Suzuki, K Suzuki, S Y Suzuki, Y Suzuki, R Tacik, M Tada, S Takahashi, A Takeda, Y Takeuchi, H K Tanaka, H A Tanaka, D Terhorst, R Terri, T Thakore, L F Thompson, S Tobayama, W Toki, T Tomura, C Touramanis, T Tsukamoto, M Tzanov, Y Uchida, A Vacheret, M Vagins, Z Vallari, G Vasseur, T Wachala, K Wakamatsu, C W Walter, D Wark, W Warzycha, M O Wascko, A Weber, R Wendell, R J Wilkes, M J Wilking, C Wilkinson, J R Wilson, R J Wilson, Y Yamada, K Yamamoto, M Yamamoto, C Yanagisawa, T Yano, S Yen, N Yershov, M Yokoyama, J Yoo, K Yoshida, T Yuan, M Yu, A Zalewska, J Zalipska, L Zambelli, K Zaremba, M Ziembicki, E D Zimmerman, M Zito, J Żmuda
We report the first measurement of the flux-averaged cross section for charged current coherent π^{+} production on carbon for neutrino energies less than 1.5 GeV, and with a restriction on the final state phase space volume in the T2K near detector, ND280. Comparisons are made with predictions from the Rein-Sehgal coherent production model and the model by Alvarez-Ruso et al., the latter representing the first implementation of an instance of the new class of microscopic coherent models in a neutrino interaction Monte Carlo event generator...
November 4, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27818173/the-trp-channels-pkd2-nompc-and-trpm-act-in-cold-sensing-neurons-to-mediate-unique-aversive-behaviors-to-noxious-cold-in-drosophila
#16
Heather N Turner, Kevin Armengol, Atit A Patel, Nathaniel J Himmel, Luis Sullivan, Srividya Chandramouli Iyer, Surajit Bhattacharya, Eswar Prasad R Iyer, Christian Landry, Michael J Galko, Daniel N Cox
The basic mechanisms underlying noxious cold perception are not well understood. We developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing temperatures via a mutually exclusive set of singular behaviors-in particular, a full-body contraction (CT). Class III (CIII) multidendritic sensory neurons are specifically activated by cold and optogenetic activation of these neurons elicits CT. Blocking synaptic transmission in CIII neurons inhibits CT. Genetically, the transient receptor potential (TRP) channels Trpm, NompC, and Polycystic kidney disease 2 (Pkd2) are expressed in CIII neurons, where each is required for CT...
December 5, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27800013/fatty-alcohol-production-in-lipomyces-starkeyi-and-yarrowia-lipolytica
#17
Wei Wang, Hui Wei, Eric Knoshaug, Stefanie Van Wychen, Qi Xu, Michael E Himmel, Min Zhang
BACKGROUND: Current biological pathways to produce biofuel intermediates amenable to separations and catalytic upgrading to hydrocarbon fuels are not cost effective. Previously, oleaginous yeasts have been investigated primarily for lipid production. However, yeasts store neutral lipids intracellularly making recovery difficult and expensive. In addition, once recovered from the cells, lipids are difficult to blend directly with the existing fuels without upgrading. We have, therefore, begun to investigate secreted fatty acid-derived products which can be easily recovered and upgraded to fuels...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27777626/directed-plant-cell-wall-accumulation-of-iron-embedding-co-catalyst-for-efficient-biomass-conversion
#18
Chien-Yuan Lin, Joseph E Jakes, Bryon S Donohoe, Peter N Ciesielski, Haibing Yang, Sophie-Charlotte Gleber, Stefan Vogt, Shi-You Ding, Wendy A Peer, Angus S Murphy, Maureen C McCann, Michael E Himmel, Melvin P Tucker, Hui Wei
BACKGROUND: Plant lignocellulosic biomass is an abundant, renewable feedstock for the production of biobased fuels and chemicals. Previously, we showed that iron can act as a co-catalyst to improve the deconstruction of lignocellulosic biomass. However, directly adding iron catalysts into biomass prior to pretreatment is diffusion limited, and increases the cost of biorefinery operations. Recently, we developed a new strategy for expressing iron-storage protein ferritin intracellularly to accumulate iron as a catalyst for the downstream deconstruction of lignocellulosic biomass...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27711819/construction-of-copper-chains-with-new-fluorescent-guanidino-functionalized-naphthyridine-ligands
#19
Christoph Krämer, Simone Leingang, Olaf Hübner, Elisabeth Kaifer, Hubert Wadepohl, Hans-Jörg Himmel
The three new blue-fluorescent ligands 2,7-bis(tetramethylguanidino)-1,8-naphthyridine (1), 2,7-bis(N,N'-dimethylethylene-guanidino)-1,8-naphthyridine (2) and 2,7-bis(N,N'-diisopropylguanidino)-1,8-naphthyridine (3) are synthesized, and their optical properties (electronic absorption and emission spectroscopy) studied. Reactions of 1 or 2 with [Cu(CH3CN)4]BF4 yield the Cu4 chain compounds [Cu4(1)2](BF4)4 (that crystallizes as [Cu4(1)2(CH3CN)2](BF4)4·2CH2Cl2) and [Cu4(2)2](BF4)4. The variations of the optical properties upon coordination are evaluated, and the electronic transitions identified by time-dependent DFT (TD-DFT) calculations...
October 3, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27711217/multi-functional-oct-enables-longitudinal-study-of-retinal-changes-in-a-vldlr-knockout-mouse-model
#20
Marco Augustin, Stanislava Fialová, Tanja Himmel, Martin Glösmann, Theresia Lengheimer, Danielle J Harper, Roberto Plasenzotti, Michael Pircher, Christoph K Hitzenberger, Bernhard Baumann
We present a multi-functional optical coherence tomography (OCT) imaging approach to study retinal changes in the very-low-density-lipoprotein-receptor (VLDLR) knockout mouse model with a threefold contrast. In the retinas of VLDLR knockout mice spontaneous retinal-chorodoidal neovascularizations form, having an appearance similar to choroidal and retinal neovascularizations (CNV and RNV) in neovascular age-related macular degeneration (AMD) or retinal angiomatous proliferation (RAP). For this longitudinal study, the mice were imaged every 4 to 6 weeks starting with an age of 4 weeks and following up to the age of 11 months...
2016: PloS One
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