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https://www.readbyqxmd.com/read/27895710/in-situ-label-free-imaging-of-hemicellulose-in-plant-cell-walls-using-stimulated-raman-scattering-microscopy
#1
Yining Zeng, John M Yarbrough, Ashutosh Mittal, Melvin P Tucker, Todd B Vinzant, Stephen R Decker, Michael E Himmel
BACKGROUND: Plant hemicellulose (largely xylan) is an excellent feedstock for renewable energy production and second only to cellulose in abundance. Beyond a source of fermentable sugars, xylan constitutes a critical polymer in the plant cell wall, where its precise role in wall assembly, maturation, and deconstruction remains primarily hypothetical. Effective detection of xylan, particularly by in situ imaging of xylan in the presence of other biopolymers, would provide critical information for tackling the challenges of understanding the assembly and enhancing the liberation of xylan from plant materials...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27881519/comparison-of-therapy-persistence-for-fixed-versus-free-combination-antihypertensives-a-retrospective-cohort-study
#2
Thomas Grimmsmann, Wolfgang Himmel
OBJECTIVES: The aim of the study was to compare therapy persistence among patients who started with one of three drug regimens: a monotherapy, or combination therapy either as a fixed combination (ie, 'single pill') or as a free combination (ie, two separate antihypertensive agents). DESIGN: In a secondary data analysis, we used descriptive statistics and multivariate logistic regression to measure the effect of the three therapy regimens on therapy persistence over 4 years...
November 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/27858422/measurement-of-coherent-%C3%AF-production-in-low-energy-neutrino-carbon-scattering
#3
K Abe, C Andreopoulos, M Antonova, S Aoki, A Ariga, S Assylbekov, D Autiero, S Ban, M Barbi, G J Barker, G Barr, P Bartet-Friburg, M Batkiewicz, F Bay, V Berardi, S Berkman, S Bhadra, A Blondel, S Bolognesi, S Bordoni, S B Boyd, D Brailsford, A Bravar, C Bronner, M Buizza Avanzini, R G Calland, T Campbell, S Cao, J Caravaca Rodríguez, S L Cartwright, R Castillo, M G Catanesi, A Cervera, D Cherdack, N Chikuma, G Christodoulou, A Clifton, J Coleman, G Collazuol, D Coplowe, L Cremonesi, A Dabrowska, G De Rosa, T Dealtry, P F Denner, S R Dennis, C Densham, D Dewhurst, F Di Lodovico, S Di Luise, S Dolan, O Drapier, K E Duffy, J Dumarchez, S Dytman, M Dziewiecki, S Emery-Schrenk, A Ereditato, T Feusels, A J Finch, G A Fiorentini, M Friend, Y Fujii, D Fukuda, Y Fukuda, A P Furmanski, V Galymov, A Garcia, S G Giffin, C Giganti, F Gizzarelli, M Gonin, N Grant, D R Hadley, L Haegel, M D Haigh, P Hamilton, D Hansen, J Harada, T Hara, M Hartz, T Hasegawa, N C Hastings, T Hayashino, Y Hayato, R L Helmer, M Hierholzer, A Hillairet, A Himmel, T Hiraki, S Hirota, M Hogan, J Holeczek, S Horikawa, F Hosomi, K Huang, A K Ichikawa, K Ieki, M Ikeda, J Imber, J Insler, R A Intonti, T J Irvine, T Ishida, T Ishii, E Iwai, K Iwamoto, A Izmaylov, A Jacob, B Jamieson, M Jiang, S Johnson, J H Jo, P Jonsson, C K Jung, M Kabirnezhad, A C Kaboth, T Kajita, H Kakuno, J Kameda, D Karlen, I Karpikov, T Katori, E Kearns, M Khabibullin, A Khotjantsev, D Kielczewska, T Kikawa, H Kim, J Kim, S King, J Kisiel, A Knight, A Knox, T Kobayashi, L Koch, T Koga, A Konaka, K Kondo, A Kopylov, L L Kormos, A Korzenev, Y Koshio, W Kropp, Y Kudenko, R Kurjata, T Kutter, J Lagoda, I Lamont, E Larkin, P Lasorak, M Laveder, M Lawe, M Lazos, T Lindner, Z J Liptak, R P Litchfield, X Li, A Longhin, J P Lopez, L Ludovici, X Lu, L Magaletti, K Mahn, M Malek, S Manly, A D Marino, J Marteau, J F Martin, P Martins, S Martynenko, T Maruyama, V Matveev, K Mavrokoridis, W Y Ma, E Mazzucato, M McCarthy, N McCauley, K S McFarland, C McGrew, A Mefodiev, C Metelko, M Mezzetto, P Mijakowski, A Minamino, O Mineev, S Mine, A Missert, M Miura, S Moriyama, Th A Mueller, S Murphy, J Myslik, T Nakadaira, M Nakahata, K G Nakamura, K Nakamura, K D Nakamura, S Nakayama, T Nakaya, K Nakayoshi, C Nantais, C Nielsen, M Nirkko, K Nishikawa, Y Nishimura, P Novella, J Nowak, H M O'Keeffe, R Ohta, K Okumura, T Okusawa, W Oryszczak, S M Oser, T Ovsyannikova, R A Owen, Y Oyama, V Palladino, J L Palomino, V Paolone, N D Patel, M Pavin, D Payne, J D Perkin, Y Petrov, L Pickard, L Pickering, E S Pinzon Guerra, C Pistillo, B Popov, M Posiadala-Zezula, J-M Poutissou, R Poutissou, P Przewlocki, B Quilain, T Radermacher, E Radicioni, P N Ratoff, M Ravonel, M A M Rayner, A Redij, E Reinherz-Aronis, C Riccio, P Rojas, E Rondio, S Roth, A Rubbia, A Rychter, R Sacco, K Sakashita, F Sánchez, F Sato, E Scantamburlo, K Scholberg, S Schoppmann, J Schwehr, M Scott, Y Seiya, T Sekiguchi, H Sekiya, D Sgalaberna, R Shah, A Shaikhiev, F Shaker, D Shaw, M Shiozawa, T Shirahige, S Short, M Smy, J T Sobczyk, H Sobel, M Sorel, L Southwell, P Stamoulis, J Steinmann, T Stewart, P Stowell, Y Suda, S Suvorov, A Suzuki, K Suzuki, S Y Suzuki, Y Suzuki, R Tacik, M Tada, S Takahashi, A Takeda, Y Takeuchi, H K Tanaka, H A Tanaka, D Terhorst, R Terri, T Thakore, L F Thompson, S Tobayama, W Toki, T Tomura, C Touramanis, T Tsukamoto, M Tzanov, Y Uchida, A Vacheret, M Vagins, Z Vallari, G Vasseur, T Wachala, K Wakamatsu, C W Walter, D Wark, W Warzycha, M O Wascko, A Weber, R Wendell, R J Wilkes, M J Wilking, C Wilkinson, J R Wilson, R J Wilson, Y Yamada, K Yamamoto, M Yamamoto, C Yanagisawa, T Yano, S Yen, N Yershov, M Yokoyama, J Yoo, K Yoshida, T Yuan, M Yu, A Zalewska, J Zalipska, L Zambelli, K Zaremba, M Ziembicki, E D Zimmerman, M Zito, J Żmuda
: We report the first measurement of the flux-averaged cross section for charged current coherent π^{+} production on carbon for neutrino energies less than 1.5 GeV, and with a restriction on the final state phase space volume in the T2K near detector, ND280. Comparisons are made with predictions from the Rein-Sehgal coherent production model and the model by Alvarez-Ruso et al., the latter representing the first implementation of an instance of the new class of microscopic coherent models in a neutrino interaction Monte Carlo event generator...
November 4, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27818173/the-trp-channels-pkd2-nompc-and-trpm-act-in-cold-sensing-neurons-to-mediate-unique-aversive-behaviors-to-noxious-cold-in-drosophila
#4
Heather N Turner, Kevin Armengol, Atit A Patel, Nathaniel J Himmel, Luis Sullivan, Srividya Chandramouli Iyer, Surajit Bhattacharya, Eswar Prasad R Iyer, Christian Landry, Michael J Galko, Daniel N Cox
The basic mechanisms underlying noxious cold perception are not well understood. We developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing temperatures via a mutually exclusive set of singular behaviors-in particular, a full-body contraction (CT). Class III (CIII) multidendritic sensory neurons are specifically activated by cold and optogenetic activation of these neurons elicits CT. Blocking synaptic transmission in CIII neurons inhibits CT. Genetically, the transient receptor potential (TRP) channels Trpm, NompC, and Polycystic kidney disease 2 (Pkd2) are expressed in CIII neurons, where each is required for CT...
October 25, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27800013/fatty-alcohol-production-in-lipomyces-starkeyi-and-yarrowia-lipolytica
#5
Wei Wang, Hui Wei, Eric Knoshaug, Stefanie Van Wychen, Qi Xu, Michael E Himmel, Min Zhang
BACKGROUND: Current biological pathways to produce biofuel intermediates amenable to separations and catalytic upgrading to hydrocarbon fuels are not cost effective. Previously, oleaginous yeasts have been investigated primarily for lipid production. However, yeasts store neutral lipids intracellularly making recovery difficult and expensive. In addition, once recovered from the cells, lipids are difficult to blend directly with the existing fuels without upgrading. We have, therefore, begun to investigate secreted fatty acid-derived products which can be easily recovered and upgraded to fuels...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27777626/directed-plant-cell-wall-accumulation-of-iron-embedding-co-catalyst-for-efficient-biomass-conversion
#6
Chien-Yuan Lin, Joseph E Jakes, Bryon S Donohoe, Peter N Ciesielski, Haibing Yang, Sophie-Charlotte Gleber, Stefan Vogt, Shi-You Ding, Wendy A Peer, Angus S Murphy, Maureen C McCann, Michael E Himmel, Melvin P Tucker, Hui Wei
BACKGROUND: Plant lignocellulosic biomass is an abundant, renewable feedstock for the production of biobased fuels and chemicals. Previously, we showed that iron can act as a co-catalyst to improve the deconstruction of lignocellulosic biomass. However, directly adding iron catalysts into biomass prior to pretreatment is diffusion limited, and increases the cost of biorefinery operations. Recently, we developed a new strategy for expressing iron-storage protein ferritin intracellularly to accumulate iron as a catalyst for the downstream deconstruction of lignocellulosic biomass...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27711819/construction-of-copper-chains-with-new-fluorescent-guanidino-functionalized-naphthyridine-ligands
#7
Christoph Krämer, Simone Leingang, Olaf Hübner, Elisabeth Kaifer, Hubert Wadepohl, Hans-Jörg Himmel
The three new blue-fluorescent ligands 2,7-bis(tetramethylguanidino)-1,8-naphthyridine (1), 2,7-bis(N,N'-dimethylethylene-guanidino)-1,8-naphthyridine (2) and 2,7-bis(N,N'-diisopropylguanidino)-1,8-naphthyridine (3) are synthesized, and their optical properties (electronic absorption and emission spectroscopy) studied. Reactions of 1 or 2 with [Cu(CH3CN)4]BF4 yield the Cu4 chain compounds [Cu4(1)2](BF4)4 (that crystallizes as [Cu4(1)2(CH3CN)2](BF4)4·2CH2Cl2) and [Cu4(2)2](BF4)4. The variations of the optical properties upon coordination are evaluated, and the electronic transitions identified by time-dependent DFT (TD-DFT) calculations...
October 3, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27711217/multi-functional-oct-enables-longitudinal-study-of-retinal-changes-in-a-vldlr-knockout-mouse-model
#8
Marco Augustin, Stanislava Fialová, Tanja Himmel, Martin Glösmann, Theresia Lengheimer, Danielle J Harper, Roberto Plasenzotti, Michael Pircher, Christoph K Hitzenberger, Bernhard Baumann
We present a multi-functional optical coherence tomography (OCT) imaging approach to study retinal changes in the very-low-density-lipoprotein-receptor (VLDLR) knockout mouse model with a threefold contrast. In the retinas of VLDLR knockout mice spontaneous retinal-chorodoidal neovascularizations form, having an appearance similar to choroidal and retinal neovascularizations (CNV and RNV) in neovascular age-related macular degeneration (AMD) or retinal angiomatous proliferation (RAP). For this longitudinal study, the mice were imaged every 4 to 6 weeks starting with an age of 4 weeks and following up to the age of 11 months...
2016: PloS One
https://www.readbyqxmd.com/read/27686459/esicm-lives-2016-part-three-milan-italy-1-5-october-2016
#9
T Velasquez, G Mackey, J Lusk, U G Kyle, T Fontenot, P Marshall, L S Shekerdemian, J A Coss-Bu, A Nishigaki, T Yatabe, T Tamura, K Yamashita, M Yokoyama, J C Ruiz-Rodriguez, B Encina, R Belmonte, I Troncoso, P Tormos, M Riveiro, J Baena, A Sanchez, J Bañeras, J Cordón, N Duran, A Ruiz, J Caballero, X Nuvials, J Riera, J Serra, A M F Rutten, S N M van Ieperen, E P H M Der Kinderen, T Van Logten, L Kovacikova, P Skrak, M Zahorec, U G Kyle, A Akcan-Arikan, J C Silva, G Mackey, J Lusk, M Goldsworthy, L S Shekerdemian, J A Coss-Bu, D Wood, D Harrison, R Parslow, P Davis, J Pappachan, S Goodwin, P Ramnarayan, S Chernyshuk, H Yemets, V Zhovnir, S M Pulitano', S De Rosa, A Mancino, G Villa, F Tosi, P Franchi, G Conti, B Patel, H Khine, A Shah, D Sung, L Singer, S Haghbin, S Inaloo, Z Serati, M Idei, T Nomura, N Yamamoto, Y Sakai, T Yoshida, Y Matsuda, Y Yamaguchi, S Takaki, O Yamaguchi, T Goto, N Longani, S Medar, I R Abdel-Aal, A S El Adawy, H M E H Mohammed, A N Mohamed, S M Parry, L D Knight, L Denehy, N De Morton, C E Baldwin, D Sani, G Kayambu, V Z M da Silva, P Phongpagdi, Z A Puthucheary, C L Granger, J E Rydingsward, C M Horkan, K B Christopher, D McWilliams, C Jones, E Reeves, G Atkins, C Snelson, L M Aitken, J Rattray, J Kenardy, A M Hull, A Ullman, R Le Brocque, M Mitchell, C Davis, B Macfarlane, J C Azevedo, L L Rocha, F F M De Freitas, A M Cavalheiro, N M Lucinio, M S Lobato, G Ebeling, A Kraegpoeth, E Laerkner, I De Brito-Ashurst, C White, S Gregory, L G Forni, E Flowers, A Curtis, C A Wood, K Siu, K Venkatesan, J B H Muhammad, L Ng, E Seet, N Baptista, A Escoval, E Tomas, R Agrawal, R Mathew, A Varma, E Dima, E Charitidou, E Perivolioti, M Pratikaki, C Vrettou, A Giannopoulos, S Zakynthinos, C Routsi, E Atchade, S Houzé, S Jean-Baptiste, G Thabut, C Genève, S Tanaka, B Lortat-Jacob, P Augustin, M Desmard, P Montravers, F J González de Molina, S Barbadillo, R Alejandro, F Álvarez-Lerma, J Vallés, R M Catalán, E Palencia, A Jareño, R M Granada, M L Ignacio, N Cui, D Liu, H Wang, L Su, H Qiu, R Li, K Jaffal, A Rouzé, J Poissy, B Sendid, S Nseir, E Paramythiotou, M Rizos, F Frantzeskaki, A Antoniadou, S Vourli, L Zerva, A Armaganidis, J Riera, J Gottlieb, M Greer, O Wiesner, M Martínez, M Acuña, J Rello, T Welte, E Atchade, T Mignot, S Houzé, S Jean-Baptiste, G Thabut, B Lortat-Jacob, S Tanaka, P Augustin, M Desmard, P Montravers, S Soussi, E Dudoignon, A Ferry, M Chaussard, M Benyamina, A Alanio, S Touratier, M Chaouat, M Lafaurie, M Mimoun, A Mebazaa, M Legrand, M A Sheils, C Patel, L Mohankumar, N Akhtar, S K Pacheco Noriega, N Navarrete Aldana, J L Ávila León, J Durand Baquero, F Fernández Bernal, E Ahmadnia, J S Hadley, M Millar, D Hall, H Hewitt, H Yasuda, M Sanui, T Komuro, S Kawano, K Andoh, H Yamamoto, E Noda, J Hatakeyama, N Saitou, H Okamoto, A Kobayashi, T Takei, S Matsukubo, H B Rotzel, A Serrano Lázaro, D Aguillón Prada, M Rodriguez Gimillo, O Diaz Barinas, M L Blasco Cortes, J Ferreres Franco, J M Segura Roca, A Carratalá, B Gonçalves, R Turon, A Mendes, F Miranda, P J Mata, D Cavalcanti, N Melo, P Lacerda, P Kurtz, C Righy, L E de la Cruz Rosario, S P Gómez Lesmes, J C García Romero, A N García Herrera, E D Díaz Pertuz, M J Gómez Sánchez, E Regidor Sanz, J Barado Hualde, A Ansotegui Hernández, J M Guergué Irazabal, V Spatenkova, O Bradac, P Suchomel, T Urli, E Heusch Lazzeri, R Aspide, M Zanello, L Perez-Borrero, J M Garcia-Alvarez, M D Arias-Verdu, E Aguilar-Alonso, R Rivera-Fernandez, J Mora-Ordoñez, C De La Fuente-Martos, E Castillo-Lorente, F Guerrero-Lopez, S P Gómez Lesmes, L E De la Cruz Rosario, E D Díaz Pertuz, A Ansotegui Hernández, J C García Romero, M J Gómez Sánchez, A N García Herrera, J Roldán Ramírez, E Regidor Sanz, J Barado Hualde, J P Tirapu León, L Navarro-Guillamón, S Cordovilla-Guardia, A Iglesias-Santiago, F Guerrero-López, E Fernández-Mondéjar, A Vidal, M Perez, A Juez, N Arias, L Colino, J L Perez, H Pérez, P Calpe, M A Alcala, D Robaglia, C Perez, S K Lan, M M Cunha, T Moreira, F Santos, E Lafuente, M J Fernandes, J G Silva, L E de la Cruz Rosario, S P Gómez Lesmes, A N García Herrera, J C García Romero, E D Díaz Pertuz, M J Gómez Sánchez, E Regidor Sanz, J G Armando Echeverría, A Ansotegui Hernández, J Barado Hualde, V Podlepich, E Sokolova, E Alexandrova, K Lapteva, P Kurtz, C Shuinotsuka, L Rabello, G Vianna, A Reis, C Cairus, J Salluh, F Bozza, J C Barrios Torres, N J Fernández Araujo, P García-Olivares, E Keough, M Dalorzo, L K Tang, I De Sousa, M Díaz, L J Marcos-Zambrano, J E Guerrero, S E Zamora Gomez, G D Hernandez Lopez, A I Vazquez Cuellar, O R Perez Nieto, J A Castanon Gonzalez, D Bhasin, S Rai, H Singh, O Gupta, M K Bhattal, S Sampley, K Sekhri, R Nandha, F A Aliaga, F Olivares, F Appiani, P Farias, F Alberto, A Hernández, S Pons, R Sonneville, L Bouadma, M Neuville, E Mariotte, A Radjou, J Lebut, S Chemam, G Voiriot, M P Dilly, B Mourvillier, R Dorent, P Nataf, M Wolff, J F Timsit, O Ediboglu, S Ataman, H Ozkarakas, C Kirakli, A Vakalos, V Avramidis, O Obukhova, I A Kurmukov, S Kashiya, E Golovnya, V N Baikova, T Ageeva, T Haritydi, E V Kulaga, J J Rios-Toro, L Perez-Borrero, E Aguilar-Alonso, M D Arias-Verdu, J M Garcia-Alvarez, C Lopez-Caler, C De La Fuente-Martos, S Rodriguez-Fernandez, M Gomez Sanchez-Orézzoli, F Martin-Gallardo, J Nikhilesh, V Joshi, E Villarreal, J Ruiz, M Gordon, A Quinza, J Gimenez, M Piñol, A Castellanos, P Ramirez, Y D Jeon, W Y Jeong, M H Kim, I Y Jeong, M Y Ahn, J Y Ahn, S H Han, J Y Choi, Y G Song, J M Kim, N S Ku, H Shah, F Kellner, F Rezai, N Mistry, P Yodice, V Ovnanian, K Fless, E Handler, R Martínez Alejos, J D Martí Romeu, D González Antón, A Quinart, A Torres Martí, M Llaurado-Serra, A Lobo-Civico, A Ventura-Rosado, A Piñol-Tena, M Pi-Guerrero, C Paños-Espinosa, M Peralvo-Bernat, J Marine-Vidal, R Gonzalez-Engroba, N Montesinos-Cerro, M Treso-Geira, A Valeiras-Valero, L Martinez-Reyes, A Sandiumenge, M F Jimenez-Herrera, S Helyar, P Riozzi, A Noon, G Hallows, H Cotton, J Keep, P A Hopkins, A Taggu, S Renuka, S Sampath, P J T Rood, T Frenzel, R Verhage, M Bonn, P Pickkers, J G van der Hoeven, M van den Boogaard, F Corradi, L Melnyk, F Moggia, R Pienovi, G Adriano, C Brusasco, L Mariotti, M Lattuada, M J Bloomer, M Coombs, K Ranse, R Endacott, B Maertens, K Blot, S Blot, M P van Nieuw Amerongen, E S van der Heiden, J W R Twisk, A R J Girbes, J J Spijkstra, P Riozzi, S Helyar, H Cotton, G Hallows, A Noon, C Bell, K Peters, A Feehan, J Keep, P A Hopkins, K Churchill, K Hawkins, R Brook, N Paver, R Endacott, N Maistry, A van Wijk, N Rouw, T van Galen, S Evelein-Brugman, A Taggu, B Krishna, S Sampath, A Putzu, M Fang, M Boscolo Berto, A Belletti, T Cassina, L Cabrini, M Mistry, Y Alhamdi, I Welters, S T Abrams, C H Toh, H S Han, E M Gil, D S Lee, C M Park, S Winder-Rhodes, R Lotay, J Doyle, M W Ke, W C Huang, C H Chiang, W T Hung, C C Cheng, K C Lin, S C Lin, K R Chiou, S R Wann, C W Shu, P L Kang, G Y Mar, C P Liu, S Dubó, A Aquevedo, M Jibaja, D Berrutti, C Labra, R Lagos, M F García, V Ramirez, M Tobar, F Picoita, C Peláez, D Carpio, L Alegría, C Hidalgo, K Godoy, J Bakker, G Hernández, Y Sadamoto, K Katabami, T Wada, Y Ono, K Maekawa, M Hayakawa, A Sawamura, S Gando, H Marin-Mateos, J L Perez-Vela, R Garcia-Gigorro, M A Corres Peiretti, M J Lopez-Gude, S Chacon-Alves, E Renes-Carreño, J C Montejo-González, K L Parlevliet, H R W Touw, M Beerepoot, C Boer, P W G Elbers, P R Tuinman, S A Abdelmonem, T A Helmy, I El Sayed, S Ghazal, S H Akhlagh, M Masjedi, K Hozhabri, E Kamali, I Zýková, B Paldusová, P Sedlák, D Morman, A M Youn, Y Ohta, M Sakuma, D Bates, T Morimoto, P L Su, W Y Chang, W C Lin, C W Chen, F Facchin, F Zarantonello, G Panciera, A De Cassai, A Venrdramin, A Ballin, T Tonetti, P Persona, C Ori, L Del Sorbo, S Rossi, G Vergani, M Cressoni, D Chiumello, C Chiurazzi, M Brioni, I Algieri, T Tonetti, M Guanziroli, A Colombo, I Tomic, A Colombo, F Crimella, E Carlesso, V Gasparovic, L Gattinoni, A Serpa Neto, M Schmidt, T Pham, A Combes, M Gama de Abreu, P Pelosi, M J Schultz, B H Katira, D Engelberts, R E Giesinger, C Ackerley, T Yoshida, D Zabini, G Otulakowski, M Post, W M Kuebler, P J McNamara, B P Kavanagh, R Pirracchio, M Resche Rigon, M Carone, S Chevret, D Annane, S Eladawy, M El-Hamamsy, N Bazan, M Elgendy, G De Pascale, M S Vallecoccia, S L Cutuli, V Di Gravio, M A Pennisi, G Conti, M Antonelli, D T Andreis, W Khaliq, M Singer, J Hartmann, S Harm, S Alcantara Carmona, P Matia Almudevar, A Naharro Abellán, J Veganzones Ramos, L Pérez Pérez, B Lobo Valbuena, N Martínez Sanz, I Fernández Simón, M Arrigo, E Feliot, N Deye, A Cariou, B Guidet, S Jaber, M Leone, M Resche-Rigon, A Vieillard Baron, M Legrand, E Gayat, A Mebazaa, M Balik, I Kolnikova, M Maly, P Waldauf, G Tavazzi, J Kristof, A Herpain, F Su, E Post, F Taccone, J L Vincent, J Creteur, C Lee, F Hatib, Z Jian, S Buddi, M Cannesson, S Fileković, M Turel, R Knafelj, V Gorjup, R Stanić, P Gradišek, O Cerović, T Mirković, M Noč, J Tirkkonen, H Hellevuo, K T Olkkola, S Hoppu, K C Lin, W T Hung, C C Chiang, W C Huang, W C Juan, S C Lin, C C Cheng, P H Lin, K Y Fong, D S Hou, P L Kang, S R Wann, Y S Chen, G Y Mar, C P Liu, M Paul, W Bougouin, G Geri, F Dumas, B Champigneulle, S Legriel, J Charpentier, J P Mira, C Sandroni, A Cariou, J Zimmerman, E Sullivan, M Noursadeghi, B Fox, D Sampson, L McHugh, T Yager, S Cermelli, T Seldon, S Bhide, R A Brandon, R B Brandon, J Zwaag, R Beunders, P Pickkers, M Kox, F Gul, M K Arslantas, D Genc, N Zibandah, L Topcu, T Akkoc, I Cinel, E Greco, M P Lauretta, D T Andreis, M Singer, I Palacios Garcia, M Cordero, A Diaz Martin, T Aldabó Pallás, J Garnacho Montero, J Revuelto Rey, L Roman Malo, A A Tanaka Montoya, A D C Amador Martinez, L Y Delgado Ayala, E Monares Zepeda, J Franco Granillo, J Aguirre Sanchez, G Camarena Alejo, A Rugerio Cabrera, A Pedraza Montenegro, T Pham, G Beduneau, F Schortgen, L Piquilloud, E Zogheib, M Jonas, F Grelon, I Runge, N Terzi, S Grangé, G Barberet, P G Guitard, 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Gandolfi, E Montini, S Orlando, M van Nes, F Karachi, S Hanekom, A H Andrade, U V Pereira, C A C Abreu Filho, R C Costa, M S W Parkin, M Moore, A H Andrade, R C Costa, K V Silva Carvalho, C A C Abreu Filho, H J Min, H J Kim, D S Lee, Y Y Choi, E Y Lee, I Song, D J Kim, Y Y E, J W Kim, J S Park, Y J Cho, J H Lee, J W Suh, Y H Jo, K S Kim, Y J Lee, J Ferrero-Calleja, D Merino-Vega, A I González-Jiménez, M Sigcha Sigcha, A Hernández-Tejedor, A Martin-Vivas, Á Gabán-Díez, R Ruiz-de Luna, N De la Calle-Pedrosa, I Temprano-Gómez, D Afonso-Rivero, J I Pellin-Ariño, A Algora-Weber, R R L Fumis, A B Ferraz, J M Vieira Junior, H Kirca, O Cakin, M Unal, H Mutlu, A Ramazanoglu, M Cengiz, E A Nicolini, F G F Pelisson, R S Nunes, S L da Silva, M M Carreira, F Bellissimo-Rodrigues, M A Ferez, A Basile-Filho, H C Chao, C M Chen, L Chen, M Hravnak, G Clermont, M Pinsky, A Dubrawski, J Luján Varas, R Molina Montero, L Alcázar Sánchez-Elvira, P Villa Díaz, C Pintado Delgado, B Llorente Ruiz, A Pardo Guerrero, J A Cambronero Galache, H Sherif, H Hassanin, R El Hossainy, W Samy, H Ly, H David, P Burtin, C Charpentier, M Barral, P Courant, E Fournel, L Gaide-Chevronnay, M Durand, P Albaladejo, J F Payen, O Chavanon, A Blandino Ortiz, S Pozzebon, O Lheureux, A Brasseur, J L Vincent, J Creteur, F S Taccone, F Fumagalli, S Scala, R Affatato, M De Maglie, D Zani, D Novelli, C Marra, A Luciani, D De Zani, M Luini, T Letizia, D Pravettoni, L Staszewsky, S Masson, A Belloli, M Di Giancamillo, E Scanziani, R Latini, G Ristagno, Y C Kye, G J Suh, W Y Kwon, K S Kim, K M Yu, G Babini, G Ristagno, L Grassi, F Fumagalli, S Bendel, M De Maglie, R Affatato, S Masson, R Latini, E Scanziani, M Reinikainen, M Skrifvars, F Kappler, M Blobner, S J Schaller, A Roasio, E Costanzo, S Cardellino, E Iesu, F Zama Cavicchi, V Fontana, L Nobile, J L Vincent, J Creteur, F S Taccone, M Park, K M You, G J Suh, W Y Kwon, S B Ko, K S Kim, A Xini, L Marca, O Lheureux, A Brasseur, J L Vincent, J Creteur, F S Taccone, A Beane, M C K T Thilakasiri, A P De Silva, T Stephens, C S Sigera, P Athapattu, S Jayasinghe, A Padeniya, R Haniffa, A Iglesias Santiago, V Chica Sáez, R de la Chica Ruiz-Ruano, A Sánchez González, N Kunze-Szikszay, S Wand, P Klapsing, A Wetz, T Heyne, K Schwerdtfeger, M Troeltzsch, M Bauer, M Quintel, O Moerer, D J Cook, W B Rutherford, D C Scales, N K Adhikari, B H Cuthbertson, T Suzuki, T Takei, K Fushimi, M Iwamoto, S Nakagawa, N Mendsaikhan, T Begzjav, G Lundeg, M W Dünser, D González Romero, J L Santana Cabrera, J D Martín Santana, Y Santana Padilla, H Rodríguez Pérez, R Lorenzo Torrent, R Kleinpell, I Chouris, V Radu, M Stougianni, A Lavrentieva, D Lagonidis, R D T Price, A Day, N Arora, M A Henderson, S Hickey, M I Almeida Costa, J P Carvalho, A A Gomes, P J Mergulhão, K K C Chan, H P Shum, W W Yan, B Maghsoudi, S H Tabei, M Masjedi, G Sabetian, H R Tabatabaei, A Akbarzadeh, S Saigal, A Pakhare, R Joshi, S K Pattnaik, B Ray, A F Rousseau, L Michel, M Bawin, E Cavalier, J Y Reginster, P Damas, O Bruyere, J C Zhou, H Cauwenberghs, A De Backer, H Neels, I Deblier, J Berghmans, D Himpe, J A Barea-Mendoza, I Prieto Portillo, M Valiente Fernández, R Garcia Gigorro, J L Perez Vela, H Marín Mateos, S Chacón Alves, G Morales Varas, A Rodriguez-Biendicho, E Renes Carreño, J C Montejo González, J S Yang, C H Chiang, W T Hung, W C Huang, C C Cheng, K C Lin, S C Lin, K R Chiou, S R Wann, K L Lin, P L Kang, G Y Mar, C P Liu, J C Zhou, Y J Choi, S Z Yoon, A Gordillo-Brenes, M D Fernandez-Zamora, L Perez-Borrero, M D Arias-Verdu, E Aguilar-Alonso, A Herruzo-Aviles, M Garcia-Delgado, R Hinojosa-Perez, E Curiel-Balsera, R Rivera-Fernandez, S P Gómez Lesmes, L E De la Cruz Rosario, A Ansotegui Hernández, A N García Herrera, E Regidor Sanz, M J Gómez Sánchez, J Barado Hualde, O Agudo Pascual, J P Tirapu León, J M Guergue Irazabal, A González Pérez, P Alvarez Fernández, L Lopéz Amor, G Muñiz Albaiceta, S P Gómez Lesmes, L E De la Cruz Rosario, A Ansotegui Hernández, E Regidor Sanz, M J Gómez Sánchez, S Aldunate Calvo, A N García Herrera, J Barado Hualde, O Agudo Pascual, J P Tirapu León, A Corona, C Ruffini, A Spazzadeschi, F Marrazzo, A Gandola, R Sciurti, C Savi, E Catena, M W Ke, C C Cheng, W C Huang, C H Chiang, W T Hung, K C Lin, S C Lin, S R Wann, K R Chiou, C J Tseng, P L Kang, G Y Mar, C P Liu, P Bertini, F De Sanctis, F Guarracino, P Bertini, R Baldassarri, F Guarracino, S H Buitinck, P H J van der Voort, J Oto, E Nakataki, Y Tsunano, M Izawa, N Tane, M Onodera, M Nishimura, S Ghosh, A Gupta, A De Gasperi, E Mazza, R Limuti, M Prosperi, N Bissenova, A Yergaliyeva, L Talan, G Yılmaz, G Güven, F Yoruk, N D Altıntas, D N Mukherjee, L K Agarwal, K Mandal, M Palomar, B Balsera, M Vallverdu, M Martinez, M Garcia, D Castellana, R Lopez, F Barcenilla, G E Kaminsky, R Carreño, A Escribá, M Fuentes, V Gálvez, R Del Olmo, B Nieto, C Vaquerizo, J Alvarez, M A De la Torre, E Torres, E Bogossian, S Aranha Nouer, D Ribeiro Salgado, S Carvalho Brugger, G Jiménez Jiménez, M Miralbés Torner, M Vallverdú Vidal, B Balsera Garrido, X Nuvials Casals, F Barcenilla Gaite, J Trujillano Cabello, M Palomar Martínez, M Doganci, S Izdes, S Guzeldag Besevli, A Alkan, B Kayaaslan, C Sánchez Ramírez, L Caipe Balcázar, M Cabrera Santana, M A Hernández Viera, S Hípola Escalada, C F Lübbe Vázquez, S M Marrero Penichet, F Artiles Campelo, M A De La Cal López, P Saavedra Santana, S Ruíz Santana, X Repessé, M Artiguenave, S Paktoris-Papine, F Espinasse, A Dinh, F El Sayed, C Charron, G Géri, A Vieillard-Baron, K Marmanidou, M Oikonomou, C Nouris, K Dimitroulakis, E Soilemezi, D Matamis, A Ferré, M Guillot, J L Teboul, D Lichtenstein, G Mézière, C Richard, X Monnet, T Pham, G Beduneau, F Schortgen, L Piquilloud, E Zogheib, M Jonas, F Grelon, I Runge, N Terzi, S Grangé, G Barberet, P G Guitard, J P Frat, A Constan, J M Chrétien, J Mancebo, A Mercat, J C M Richard, L Brochard, S Prīdāne, O Sabeļņikovs, F Mojoli, A Orlando, I Bianchi, F Torriglia, S Bianzina, M Pozzi, G A Iotti, A Braschi, G Beduneau, T Pham, F Schortgen, L Piquilloud, E Zogheib, M Jonas, F Grelon, I Runge, N Terzi, S Grangé, G Barberet, P G Guitard, J P Frat, A Constan, J M Chrétien, J Mancebo, A Mercat, J C M Richard, L Brochard, E Kondili, C Psarologakis, S Kokkini, V Amargianitakis, D Babalis, A Chytas, I Chouvarda, K Vaporidi, D Georgopoulos, O Trapp, A Kalenka, F Mojoli, A Orlando, I Bianchi, F Torriglia, S Bianzina, M Pozzi, G A Iotti, A Braschi, J A Benítez Lozano, P Carmona Sánchez, J E Barrueco Francioni, F Ruiz Ferrón, J M Serrano Simón, S Spadaro, D S Karbing, A Gioia, F Moro, F Dalla Corte, T Mauri, C A Volta, S E Rees, M V Petrova, R Mohan, A V Butrov, S D Beeharry, M V Vatsik, F I Sakieva, F Gobert, H Yonis, R Tapponnier, R Fernandez, M A Labaune, J F Burle, J Barbier, B Vincent, M Cleyet, J C Richard, C Guérin, C Righy Shinotsuka, J Creteur, F S Taccone, S Törnblom, S Nisula, S Vaara, M Poukkanen, S Andersson, V Pettilä, E Pesonen, Z Xie, X Liao, Y Kang, J Zhang, K Kubota, M Egi, S Mizobuchi, S Hegazy, A El-Keraie, E El Sayed, M Abd El Hamid, N J Rodrigues, M Pereira, I Godinho, J Gameiro, M Neves, J Gouveia, Z Costa E Silva, J A Lopes, J Mckinlay, M Kostalas, G Kooner, G Dudas, A Horton, C Kerr, N Karanjia, B Creagh-Brown, L Forni, A Yamazaki, M Sanz Ganuza, J A Martinez Molina, F Hidalgo Martinez, M T Chiquito Freile, N Garcia Fernandez, P Medrano Travieso, A Bandert, R Frithiof, M Lipcsey, D Smekal, P Schlaepfer, J D Durovray, V Plouhinec, C Chiappa, R Bellomo, A G Schneider, S Mitchell, J Durrant, H Street, E Dunthorne, J Shears, C Hernandez Caballero, R Hutchison, S Schwarze, S Ghabina, E Thompson, J R Prowle, C J Kirwan, C A Gonzalez, J L Pinto, V Orozco, J A Patiño, P K Garcia, K M Contreras, P Rodriguez, J E Echeverri
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27678259/copper-complexes-of-new-redox-active-4-5-bisguanidino-substituted-benzodioxole-ligands-control-of-the-electronic-structure-by-counter-ligands-solvent-and-temperature
#10
David Fridolin Schrempp, Elisabeth Kaifer, Hubert Wadepohl, Hans-Jörg Himmel
Herein, we analyze the possibility of controlling the electronic structure of mononuclear copper complexes featuring new redox-active 4,5-bisguanidino-substituted benzodioxole ligands. The nature of the guanidino groups, the anionic counter-ligands, the applied solvent (polarity), and the temperature are the parameters that decide if a Cu(II) complex with neutral ligand unit or a Cu(I) complex with radical monocationic ligand unit is the adequate description. Under special conditions, a temperature-dependent equilibrium of the two valence tautomeric forms (Cu(II) /neutral ligand and Cu(I) /radical monocationic ligand) is achieved...
November 2, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27629544/zymomonas-mobilis-as-a-model-system-for-production-of-biofuels-and-biochemicals
#11
Shihui Yang, Qiang Fei, Yaoping Zhang, Lydia M Contreras, Sagar M Utturkar, Steven D Brown, Michael E Himmel, Min Zhang
Zymomonas mobilis is a natural ethanologen with many desirable industrial biocatalyst characteristics. In this review, we will discuss work to develop Z. mobilis as a model system for biofuel production from the perspectives of substrate utilization, development for industrial robustness, potential product spectrum, strain evaluation and fermentation strategies. This review also encompasses perspectives related to classical genetic tools and emerging technologies in this context.
September 15, 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/27623051/correction-to-wood-derived-materials-for-green-electronics-biological-devices-and-energy-applications
#12
Hongli Zhu, Wei Luo, Peter N Ciesielski, Zhiqiang Fang, J Y Zhu, Gunnar Henriksson, Michael E Himmel, Liangbing Hu
No abstract text is available yet for this article.
October 12, 2016: Chemical Reviews
https://www.readbyqxmd.com/read/27602047/controlling-dna-end-resection-an-emerging-task-for-ubiquitin-and-sumo
#13
REVIEW
Sarah-Felicitas Himmels, Alessandro A Sartori
DNA double-strand breaks (DSBs) are one of the most detrimental lesions, as their incorrect or incomplete repair can lead to genomic instability, a hallmark of cancer. Cells have evolved two major competing DSB repair mechanisms: Homologous recombination (HR) and non-homologous end joining (NHEJ). HR is initiated by DNA-end resection, an evolutionarily conserved process that generates stretches of single-stranded DNA tails that are no longer substrates for religation by the NHEJ machinery. Ubiquitylation and sumoylation, the covalent attachment of ubiquitin and SUMO moieties to target proteins, play multifaceted roles in DNA damage signaling and have been shown to regulate HR and NHEJ, thus ensuring appropriate DSB repair...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27594916/metabolic-engineering-of-zymomonas-mobilis-for-2-3-butanediol-production-from-lignocellulosic-biomass-sugars
#14
Shihui Yang, Ali Mohagheghi, Mary Ann Franden, Yat-Chen Chou, Xiaowen Chen, Nancy Dowe, Michael E Himmel, Min Zhang
BACKGROUND: To develop pathways for advanced biofuel production, and to understand the impact of host metabolism and environmental conditions on heterologous pathway engineering for economic advanced biofuels production from biomass, we seek to redirect the carbon flow of the model ethanologen Zymomonas mobilis to produce desirable hydrocarbon intermediate 2,3-butanediol (2,3-BDO). 2,3-BDO is a bulk chemical building block, and can be upgraded in high yields to gasoline, diesel, and jet fuel...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27561354/cullin3-klhl15-ubiquitin-ligase-mediates-ctip-protein-turnover-to-fine-tune-dna-end-resection
#15
Lorenza P Ferretti, Sarah-Felicitas Himmels, Anika Trenner, Christina Walker, Christine von Aesch, Aline Eggenschwiler, Olga Murina, Radoslav I Enchev, Matthias Peter, Raimundo Freire, Antonio Porro, Alessandro A Sartori
Human CtIP is a decisive factor in DNA double-strand break repair pathway choice by enabling DNA-end resection, the first step that differentiates homologous recombination (HR) from non-homologous end-joining (NHEJ). To coordinate appropriate and timely execution of DNA-end resection, CtIP function is tightly controlled by multiple protein-protein interactions and post-translational modifications. Here, we identify the Cullin3 E3 ligase substrate adaptor Kelch-like protein 15 (KLHL15) as a new interaction partner of CtIP and show that KLHL15 promotes CtIP protein turnover via the ubiquitin-proteasome pathway...
2016: Nature Communications
https://www.readbyqxmd.com/read/27555882/heterologous-expression-of-family-10-xylanases-from-acidothermus-cellulolyticus-enhances-the-exoproteome-of-caldicellulosiruptor-bescii-and-growth-on-xylan-substrates
#16
Sun-Ki Kim, Daehwan Chung, Michael E Himmel, Yannick J Bomble, Janet Westpheling
BACKGROUND: The ability to deconstruct plant biomass without conventional pretreatment has made members of the genus Caldicellulosiruptor the target of investigation for the consolidated processing of lignocellulosic biomass to biofuels and bioproducts. These Gram-positive bacteria are hyperthermophilic anaerobes and the most thermophilic cellulolytic organisms so far described. They use both C5 and C6 sugars simultaneously and have the ability to grow well on xylan, a major component of plant cell walls...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27555377/minocycline-a-putative-neuroprotectant-co-administered-with-doxorubicin-cyclophosphamide-chemotherapy-in-a-xenograft-model-of-triple-negative-breast-cancer
#17
Lauren E Himmel, Maryam B Lustberg, A Courtney DeVries, Ming Poi, Ching-Shih Chen, Samuel K Kulp
Minocycline is purported to have neuroprotective properties in experimental models of some human neurologic diseases, and has therefore been identified as a putative neuroprotectant for chemotherapy-induced cognitive impairment (CICI) in breast cancer patients. However, because its mechanism of action is believed to be mediated through anti-inflammatory, anti-apoptotic, and anti-oxidant pathways, co-administration of minocycline with chemotherapeutic agents has the potential to reduce the efficacy of anticancer drugs...
October 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27505751/broadband-opcpa-system-with-11-mj-output-at-1-khz-compressible-to-12-fs
#18
František Batysta, Roman Antipenkov, Jakub Novák, Jonathan T Green, Jack A Naylon, Jakub Horáček, Martin Horáček, Zbyněk Hubka, Robert Boge, Tomáš Mazanec, Bedřich Himmel, Pavel Bakule, Bedřich Rus
We report on a broadband OPCPA system, pumped at 515 nm by frequency doubled Yb:YAG thin disk lasers. The system delivers 11.3 mJ pulses at a central wavelength of 800 nm with a spatial beam quality of M<sup>2</sup> = 1.25 and > 25% pump-to-signal conversion efficiency. The broadband pulses were demonstrated to be compressible to 12 fs using a chirped mirror compressor.
August 8, 2016: Optics Express
https://www.readbyqxmd.com/read/27496238/understanding-and-reducing-the-prescription-of-hypnotics-and-sedatives-at-the-interface-of-hospital-care-and-general-practice-a-protocol-for-a-mixed-methods-study
#19
Stephanie Heinemann, Vivien Weiß, Kati Straube, Roland Nau, Thomas Grimmsmann, Wolfgang Himmel, Eva Hummers-Pradier
INTRODUCTION: Hypnotics and sedatives, especially benzodiazepines and Z-drugs, are frequently prescribed for longer periods than recommended-in spite of potential risks for patients. Any intervention to improve this situation has to take into account the interplay between different actors, interests and needs. The ultimate goal of this study is to develop-together with the professionals involved-ideas for reducing the use of hypnotics and sedatives and then to implement and evaluate adequate interventions in the hospital and at the primary and secondary care interface...
2016: BMJ Open
https://www.readbyqxmd.com/read/27479670/toxic-alcohol-calculations-and-misinterpretation-of-laboratory-results-reply
#20
Michael Fralick, Kenneth Lam, Megan E Himmel
No abstract text is available yet for this article.
August 1, 2016: JAMA Internal Medicine
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