Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Katherine A Shuster, Tzushan S Yang, Kate T Snyder, Nicole Creanza, Patrick K Mitchell, Laura B Goodman, Jennifer K Grenier, Nicholas M Tataryn, Lauren E Himmel, Katherine N Gibson-Corley
Four zebra finches in a closed research colony presented with variable clinical signs, including masses, skin lesions,shivering, and/or ruffled feathers. These birds were not responsive to treatment efforts; 3 died and one was euthanized. All4 were submitted for necropsy to determine the cause of the clinical signs. Gross necropsy and histopathologic findings fromall birds resulted in a diagnosis of round cell neoplasia in multiple organs, including the skin, liver, kidney, and reproductivetract, with intranuclear inclusion bodies in the neoplastic cells...
September 11, 2023: Comparative Medicine
#22
JOURNAL ARTICLE
Carolina Romeiro Fernandes Chagas, Mélanie Duc, Tanja Himmel, Vytautas Eigirdas, Herbert Weissenböck, Gediminas Valkiūnas
Leucocytozoon parasites (Haemosporida, Leucocytozoidae) are haemosporidians whose diversity, exo-erythrocytic development and potential vectors are the least studied. The knowledge about their exo-erythrocytic development and pathogenicity is fragmentary, resulting in an incomplete comprehension of the impact of these parasites on avian hosts. For a long time, Leucocytozoon infections were considered benign to wild birds, even though they were virulent in poultry and responsible for some wild bird population declines...
December 2023: International Journal for Parasitology. Parasites and Wildlife
#23
JOURNAL ARTICLE
Alexandra Bograd, Isabelle Himmel, Isabel B Pfister, Theo G Seiler, Beatrice E Frueh, Christoph Tappeiner
PURPOSE: To assess the feasibility and reliability of biometric measurements taken with the Eyestar 900 device in keratoconus eyes in comparison with those taken with the Pentacam HR and IOLMaster 700. METHODS: Seventy-five eyes of 75 patients with keratoconus were included. The central corneal thickness (CCT), thinnest point of corneal thickness (TCT), axial length (AL), flat (K1) and steep (K2) anterior and posterior (Kp1, Kp2) keratometry, maximal keratometry (KMax) and anterior chamber depth (ACD) were compared between the Eyestar 900, Pentacam HR and IOLMaster 700...
September 9, 2023: Graefe's Archive for Clinical and Experimental Ophthalmology
#24
JOURNAL ARTICLE
Ute Wild, Olaf Hübner, Paul Meiners, Elisabeth Kaifer, Markus Enders, Hans-Jörg Himmel
Using unconventional synthesis protocols, two redox-active triguanidine units are connected by a dithiolate bridge, aligning the two redox-active units in close proximity . The reduced, neutral and the tetracationic redox states with two dicationic triguanidine units are isolated and fully characterized, Then, the dicationic redox states are prepared by mixing the neutral and tetracationic molecules. At low temperatures, the dications are diamagnetic (singlet ground state) with two different triguanidine units (neutral and dicationic)...
August 22, 2023: Chemistry: a European Journal
#25
JOURNAL ARTICLE
Tanja Himmel, Josef Harl, Julia Matt, Nora Nedorost, Madeleine Lunardi, Mikas Ilgūnas, Tatjana Iezhova, Gediminas Valkiūnas, Herbert Weissenböck
Avian haemosporidians of the genera Plasmodium, Haemoproteus, and Leucocytozoon are common blood parasites in wild birds all over the world. Despite their importance as pathogens potentially compromising host fitness and health, little is known about the exo-erythrocytic development of these parasites, particularly during co-infections which predominate in wildlife. This study aimed to address this issue using Haemoproteus parasites of Fringilla coelebs, a common bird species of the Western Palearctic and host to a variety of haemosporidian parasite lineages...
August 18, 2023: International Journal for Parasitology
#26
JOURNAL ARTICLE
Tracey L Papenfuss, Lauren Himmel, C Frieke Kuper, Sunish Mohanan, Johannes Harleman, Susan A Elmore
The evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact interpretation...
August 14, 2023: Toxicologic Pathology
#27
JOURNAL ARTICLE
Josef Harl, Tanja Himmel, Mikas Ilgūnas, Gediminas Valkiūnas, Herbert Weissenböck
BACKGROUND: The nuclear ribosomal RNA genes of Plasmodium parasites are assumed to evolve according to a birth-and-death model with new variants originating by duplication and others becoming deleted. For some Plasmodium species, it has been shown that distinct variants of the 18S rRNA genes are expressed differentially in vertebrate hosts and mosquito vectors. The central aim was to evaluate whether avian haemosporidian parasites of the genus Haemoproteus also have substantially distinct 18S variants, focusing on lineages belonging to the Haemoproteus majoris and Haemoproteus belopolskyi species groups...
August 10, 2023: Malaria Journal
#28
JOURNAL ARTICLE
Alessandra Castiglioni, Yagai Yang, Katherine Williams, Alvin Gogineni, Ryan S Lane, Amber W Wang, Justin A Shyer, Zhe Zhang, Stephanie Mittman, Alan Gutierrez, Jillian L Astarita, Minh Thai, Jeffrey Hung, Yeqing Angela Yang, Tony Pourmohamad, Patricia Himmels, Marco De Simone, Justin Elstrott, Aude-Hélène Capietto, Rafael Cubas, Zora Modrusan, Wendy Sandoval, James Ziai, Stephen E Gould, Wenxian Fu, Yulei Wang, James T Koerber, Shomyseh Sanjabi, Ira Mellman, Shannon J Turley, Sören Müller
TGFβ signaling is associated with non-response to immune checkpoint blockade in patients with advanced cancers, particularly in the immune-excluded phenotype. While previous work demonstrates that converting tumors from excluded to inflamed phenotypes requires attenuation of PD-L1 and TGFβ signaling, the underlying cellular mechanisms remain unclear. Here, we show that TGFβ and PD-L1 restrain intratumoral stem cell-like CD8 T cell (TSCL ) expansion and replacement of progenitor-exhausted and dysfunctional CD8 T cells with non-exhausted T effector cells in the EMT6 tumor model in female mice...
August 5, 2023: Nature Communications
#29
JOURNAL ARTICLE
Mélanie Duc, Tanja Himmel, Josef Harl, Tatjana Iezhova, Nora Nedorost, Julia Matt, Mikas Ilgūnas, Herbert Weissenböck, Gediminas Valkiūnas
Haemoproteus parasites (Apicomplexa, Haemosporida) are widespread pathogens of birds, with a rich genetic (about 1900 lineages) and morphospecies (178 species) diversity. Nonetheless, their life cycles are poorly understood. The exo-erythrocytic stages of three Haemoproteus majoris (widespread generalist parasite) lineages have been previously reported, each in a different bird species. We aimed to further study and compare the development of five H. majoris lineages-hCCF5, hCWT4, hPARUS1, hPHSIB1, and hWW2-in a wider selection of natural avian hosts...
June 30, 2023: Pathogens
#30
JOURNAL ARTICLE
Christiane Kiese-Himmel
AIM: A clinical practice guideline aims to optimize patient care by recommending diagnostic or treatment pathways, based on the best available research and practical experience. Therefore, the needs and preferences of patients and their families should be incorporated. The aim of this study was to examine regulations and standards of patient involvement in guideline development, using a selective comparison of countries. METHOD: Information was extracted from publicly available websites and guidelines development manuals for the United Kingdom (UK), the United States, Canada, and Australia...
June 16, 2023: Das Gesundheitswesen
#31
JOURNAL ARTICLE
Anja Mäurer, Gudrun Himmel, Catharina Lange, Franziska Mathies, Ivayla Apostolova, Oliver Peters, Ralph Buchert
BACKGROUND: Neuropsychological testing (NPT) of geriatric inpatients can be affected by the acute illness and/or the hospitalization. OBJECTIVE: To test individualized interpretation of detailed NPT for the differentiation between primary 'neurodegenerative' etiologies (predominantly Alzheimer's disease) and 'other' etiologies (including cerebrovascular disease) of newly detected cognitive impairment in geriatric inpatients without and with delirium in remission...
June 5, 2023: Journal of Alzheimer's Disease: JAD
#32
JOURNAL ARTICLE
Mélanie Duc, Tanja Himmel, Mikas Ilgūnas, Vytautas Eigirdas, Herbert Weissenböck, Gediminas Valkiūnas
Avian haemosporidians are widespread parasites categorized into four families of the order Haemosporida (Apicomplexa). Species of the subgenus Parahaemoproteus (genus Haemoproteus) belong to the Haemoproteidae and are transmitted by Culicoides biting midges. Reports of death due to tissue damage during haemoproteosis in non-adapted birds have raised concerns about these pathogens, especially as their exo-erythrocytic development is known for only a few Haemoproteus spp. More research is needed to better understand the patterns of the parasites' development in tissues and their impact on avian hosts...
May 30, 2023: International Journal for Parasitology
#33
JOURNAL ARTICLE
#34
JOURNAL ARTICLE
Herbert Himmel, Armando Lagrutta, Matthias Vömel, Rupesh P Amin, John P Imredy, Timothy Johnson, Maya Vinzing, Judith Prescott, Robert O Blaustein
Vericiguat and its metabolite M-1 were assessed for proarrhythmic risk in nonclinical in vitro and in vivo studies. In vitro manual voltage-clamp recordings at room temperature determined the effect of vericiguat on human Ether-a-go-go Related Gene (hERG) K+ channels. Effects of vericiguat and M-1 on hERG K+ , Nav1.5, hCav1.2, hKvLQT1/1minK, and hKv4.3 channels were investigated via automated voltage-clamp recordings at ambient temperature. Effects of vericiguat and M-1 on hERG K+ and Nav1.5 channels at pathophysiological conditions were explored via manual voltage-clamp recordings at physiologic temperature...
July 2023: Journal of Pharmacology and Experimental Therapeutics
#35
JOURNAL ARTICLE
Antonio Hernandez, Naeem K Patil, Maya Brewer, Rachel Delgado, Lauren Himmel, Lauren N Lopez, Julia K Bohannon, Allison M Owen, Edward R Sherwood, Mark P de Caestecker
OBJECTIVE: Acute kidney injury is common in surgical and critically ill patients. This study examined if pretreatment with a TLR4 agonist attenuated ischemia reperfusion-induced AKI (IRI-AKI). DESIGN: A blinded, randomized controlled study in mice pretreated with PHAD, a synthetic TLR4 agonist. Two cohorts of male BALB/c mice received intraperitoneal vehicle or PHAD (10, 20, or 40 µg); or intravenous vehicle or PHAD (2, 20, or 200 µg) at 48 and 24 hours prior to unilateral renal pedicle clamping and simultaneous contralateral nephrectomy...
March 30, 2023: American Journal of Physiology. Renal Physiology
#36
JOURNAL ARTICLE
Johanna Osterbrink, Petra Walter, Simone Leingang, Hanna Pfisterer, Elisabeth Kaifer, Hans-Jörg Himmel
Copper amine oxidases are enzymes that exhibit in their active site a mononuclear copper complex and a 2,4,5-trihydroxyphenylalanine quinone (TPQ) cofactor; in the oxidative half of the catalytic cycle, the enzymes regulate their activity by a temperature-dependent electron transfer equilibrium between the CuII complex with the reduced, aminoquinol form of the cofactor and the reactive CuI complex with the corresponding oxidized, semiquinone form of the cofactor. Here, we report the first mononuclear copper complex with redox-active ligands showing quantitative, reversible electromerism between a CuII eletromer with reduced, neutral ligand and a CuI electromer with an oxidized, radical monocationic ligand...
March 16, 2023: Chemistry: a European Journal
#37
JOURNAL ARTICLE
Arianna Sala, Andrea Ardizzoni, Luca Spaggiari, Nikhil Vaidya, Jane van der Schaaf, Cosmeri Rizzato, Claudio Cermelli, Selene Mogavero, Thomas Krüger, Maximilian Himmel, Olaf Kniemeyer, Axel A Brakhage, Benjamin L King, Antonella Lupetti, Manola Comar, Francesco de Seta, Arianna Tavanti, Elisabetta Blasi, Robert T Wheeler, Eva Pericolini
Vulvovaginal candidiasis (VVC) affects nearly 3/4 of women during their lifetime, and its symptoms seriously reduce quality of life. Although Candida albicans is a common commensal, it is unknown if VVC results from a switch from a commensal to pathogenic state, if only some strains can cause VVC, and/or if there is displacement of commensal strains with more pathogenic strains. We studied a set of VVC and colonizing C. albicans strains to identify consistent in vitro phenotypes associated with one group or the other...
April 25, 2023: MBio
#38
JOURNAL ARTICLE
Richard Benton, Nathaniel J Himmel
Insect Odorant receptors and Gustatory receptors define a superfamily of seven-transmembrane domain ligand-gated ion channels (referred to here as 7TMICs), with homologs identified across Animalia except Chordata. Previously, we used sequence-based screening methods to reveal conservation of this family in unicellular eukaryotes and plants (DUF3537 proteins) (Benton et al ., 2020). Here we combine three-dimensional structure-based screening, ab initio protein folding predictions, phylogenetics and expression analyses to characterize additional candidate homologs with tertiary but little or no primary structural similarity to known 7TMICs, including proteins in disease-causing Trypanosoma...
February 20, 2023: ELife
#39
JOURNAL ARTICLE
M A Acero, P Adamson, L Aliaga, N Anfimov, A Antoshkin, E Arrieta-Diaz, L Asquith, A Aurisano, A Back, M Baird, N Balashov, P Baldi, B A Bambah, S Bashar, K Bays, R Bernstein, V Bhatnagar, D Bhattarai, B Bhuyan, J Bian, A C Booth, R Bowles, B Brahma, C Bromberg, N Buchanan, A Butkevich, S Calvez, T J Carroll, E Catano-Mur, S Childress, A Chatla, R Chirco, B C Choudhary, A Christensen, T E Coan, M Colo, L Cremonesi, G S Davies, P F Derwent, P Ding, Z Djurcic, M Dolce, D Doyle, D Dueñas Tonguino, E C Dukes, R Ehrlich, M Elkins, E Ewart, G J Feldman, P Filip, J Franc, M J Frank, H R Gallagher, R Gandrajula, F Gao, A Giri, R A Gomes, M C Goodman, V Grichine, M Groh, R Group, B Guo, A Habig, F Hakl, A Hall, J Hartnell, R Hatcher, H Hausner, M He, K Heller, V Hewes, A Himmel, B Jargowsky, J Jarosz, F Jediny, C Johnson, M Judah, I Kakorin, D M Kaplan, A Kalitkina, R Keloth, O Klimov, L W Koerner, L Kolupaeva, S Kotelnikov, R Kralik, Ch Kullenberg, M Kubu, A Kumar, C D Kuruppu, V Kus, T Lackey, K Lang, P Lasorak, J Lesmeister, S Lin, A Lister, J Liu, M Lokajicek, J M C Lopez, R Mahji, S Magill, M Manrique Plata, W A Mann, M T Manoharan, M L Marshak, M Martinez-Casales, V Matveev, B Mayes, M D Messier, H Meyer, T Miao, V Mikola, W H Miller, S Mishra, S R Mishra, A Mislivec, R Mohanta, A Moren, A Morozova, W Mu, L Mualem, M Muether, K Mulder, D Naples, A Nath, N Nayak, S Nelleri, J K Nelson, R Nichol, E Niner, A Norman, A Norrick, T Nosek, H Oh, A Olshevskiy, T Olson, J Ott, A Pal, J Paley, L Panda, R B Patterson, G Pawloski, O Petrova, R Petti, D D Phan, R K Plunkett, A Pobedimov, J C C Porter, A Rafique, L R Prais, V Raj, M Rajaoalisoa, B Ramson, B Rebel, P Rojas, P Roy, V Ryabov, O Samoylov, M C Sanchez, S Sánchez Falero, P Shanahan, S Shukla, A Sheshukov, I Singh, P Singh, V Singh, E Smith, J Smolik, P Snopok, N Solomey, A Sousa, K Soustruznik, M Strait, L Suter, A Sutton, S Swain, C Sweeney, A Sztuc, R L Talaga, B Tapia Oregui, P Tas, B N Temizel, T Thakore, R B Thayyullathil, J Thomas, E Tiras, J Tripathi, J Trokan-Tenorio, Y Torun, J Urheim, P Vahle, Z Vallari, J Vasel, T Vrba, M Wallbank, T K Warburton, M Wetstein, D Whittington, D A Wickremasinghe, T Wieber, J Wolcott, W Wu, Y Xiao, B Yaeggy, A Yallappa Dombara, A Yankelevich, K Yonehara, S Yu, Y Yu, S Zadorozhnyy, J Zalesak, Y Zhang, R Zwaska
The inclusive electron neutrino charged-current cross section is measured in the NOvA near detector using 8.02×10^{20} protons-on-target in the NuMI beam. The sample of GeV electron neutrino interactions is the largest analyzed to date and is limited by ≃17% systematic rather than the ≃7.4% statistical uncertainties. The double-differential cross section in final-state electron energy and angle is presented for the first time, together with the single-differential dependence on Q^{2} (squared four-momentum transfer) and energy, in the range 1 GeV≤E_{ν}<6 GeV...
February 3, 2023: Physical Review Letters
#40
JOURNAL ARTICLE
Megan Himmel, Meyer Balter, Zareen Ahmad, Elvira Bangert, Shafina Hasmani, Rhea Siddha, Mohammad Movahedi, Sindhu R Johnson
OBJECTIVE: We evaluated the epidemiology, manifestations, serology, comorbidities, and survival among systemic sclerosis (SSc) patients with and without sarcoidosis. METHODS: We conducted a retrospective cohort study comparing SSc patients with and without sarcoidosis. All patients fulfilled the ACR-EULAR classification criteria for SSc. Sarcoidosis was based on physician diagnosis and/or confirmatory biopsy. The primary outcome was time from diagnosis to all-cause mortality...
February 1, 2023: Journal of Rheumatology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
