keyword
MENU ▼
Read by QxMD icon Read
search

Himmele

keyword
https://www.readbyqxmd.com/read/28722282/metal-free-nitrile-diboration-through-activation-by-an-electron-rich-diborane
#1
Markus Frick, Elisabeth Kaifer, Hans-Jörg Himmel
Diboration of unsaturated organic compounds is an extremely useful reaction in synthetic chemistry. Herein we report the first diboration of a nitrile by an electron-rich diborane, mediated by an electrophilic borane. The reaction is metal-free, and all reagents are readily available.
July 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28670741/structural-mutagenic-and-in-silico-studies-of-xyloglucan-fucosylation-in-arabidopsis-thaliana-suggest-a-water-mediated-mechanism
#2
Breeanna R Urbanowicz, Vivek S Bharadwaj, Markus Alahuhta, Maria J Peña, Vladimir V Lunin, Yannick J Bomble, Shuo Wang, Jeong-Yeh Yang, Sami T Tuomivaara, Michael E Himmel, Kelley W Moremen, William S York, Michael F Crowley
The mechanistic underpinnings of the complex process of plant polysaccharide biosynthesis are poorly understood, largely due to the resistance of glycosyltransferase (GT) enzymes to structural characterization. In Arabidopsis thaliana, a glycosyl transferase family 37 (GT37) fucosyltransferase-1 (AtFUT1) catalyzes the regiospecific transfer of terminal 1,2-fucosyl residues to xyloglucan side chains - a key step in the biosynthesis of fucosylated sidechains of galactoxyloglucan. We unravel the mechanistic basis for fucosylation by AtFUT1 with a multipronged approach involving protein expression, X-ray crystallography, mutagenesis experiments and molecular simulations...
July 3, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28663545/towards-an-understanding-of-enhanced-biomass-digestibility-by-in-planta-expression-of-a-family-5-glycoside-hydrolase
#3
Bryon S Donohoe, Hui Wei, Ashutosh Mittal, Todd Shollenberger, Vladimir V Lunin, Michael E Himmel, Roman Brunecky
In planta expression of a thermophilic endoglucanase (AcCel5A) reduces recalcitrance by creating voids and other irregularities in cell walls of Arabidopsis thaliana that increase enzyme accessibility without negative impacts on plant growth or cell wall composition. Our results suggest that cellulose β-1-4 linkages can be cut sparingly in the assembling wall and that these minimal changes, made at the proper time, have an impact on plant cell wall recalcitrance without negative effects on overall plant development...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28654163/homo-and-heterobinuclear-cu-and-pd-complexes-with-a-bridging-redox-active-bisguanidino-substituted-dixoxolene-ligand-electronic-structure-and-metal-ligand-electron-transfer
#4
Hans-Jörg Himmel, David Fridolin Schrempp, Elisabeth Kaifer, Hubert Wadepohl, Elisa Schneider
A new redox-active 4,5-bisguanidino-substituted o-benzoquinone ligand L is synthesized, that allows a rational access to heterobinuclear complexes by the sequential coordination of two metals. In the examples discussed in this work, mononuclear Cu and Pd complexes are prepared in a first coordination step, and these complexes are then used as precursors to homobinuclear [Cu(II)-L(0)-Cu(II)] and heterobinuclear [Pd(II)-L(0)-Cu(II)] complexes. In the heterobinuclear complex, the Pd(II) is coordinated by the softer bisguanidine side of L and the Cu(II) by the harder dioxolene side (in line with the HSAB concept)...
June 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28650071/in-vivo-synergistic-activity-of-a-cazyme-cassette-from-acidothermus-cellulolyticus-significantly-improves-the-cellulolytic-activity-of-the-c-bescii-exoproteome
#5
Sun-Ki Kim, Daehwan Chung, Michael E Himmel, Yannick J Bomble, Janet Westpheling
The use of microbial cells to convert plant biomass directly to fuels and chemicals is referred to as consolidated bioprocessing (CBP). Members of the bacterial genus, Caldicellulosiruptor (Gram-positive, anaerobic hyperthermophiles) are capable of deconstructing plant biomass without enzymatic or chemical pretreatment. This is accomplished by the production and secretion of free, multi-domain enzymes that outperform commercial enzyme cocktails on some substrates. Here, we show that the exoproteome of C. bescii may be enhanced by the heterologous expression of enzymes from Acidothermus cellulolyticus that act synergistically to improve sugar release from complex substrates; as well as improve cell growth...
June 26, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28644674/constraints-on-oscillation-parameters-from-%C3%AE-_-e-appearance-and-%C3%AE-_-%C3%AE-disappearance-in-nova
#6
P Adamson, L Aliaga, D Ambrose, N Anfimov, A Antoshkin, E Arrieta-Diaz, K Augsten, A Aurisano, C Backhouse, M Baird, B A Bambah, K Bays, B Behera, S Bending, R Bernstein, V Bhatnagar, B Bhuyan, J Bian, T Blackburn, A Bolshakova, C Bromberg, J Brown, G Brunetti, N Buchanan, A Butkevich, V Bychkov, M Campbell, E Catano-Mur, S Childress, B C Choudhary, B Chowdhury, T E Coan, J A B Coelho, M Colo, J Cooper, L Corwin, L Cremonesi, D Cronin-Hennessy, G S Davies, J P Davies, P F Derwent, R Dharmapalan, P Ding, Z Djurcic, E C Dukes, H Duyang, S Edayath, R Ehrlich, G J Feldman, M J Frank, M Gabrielyan, H R Gallagher, S Germani, T Ghosh, A Giri, R A Gomes, M C Goodman, V Grichine, R Group, D Grover, B Guo, A Habig, J Hartnell, R Hatcher, A Hatzikoutelis, K Heller, A Himmel, A Holin, J Hylen, F Jediny, M Judah, G K Kafka, D Kalra, S M S Kasahara, S Kasetti, R Keloth, L Kolupaeva, S Kotelnikov, I Kourbanis, A Kreymer, A Kumar, S Kurbanov, K Lang, W M Lee, S Lin, J Liu, M Lokajicek, J Lozier, S Luchuk, K Maan, S Magill, W A Mann, M L Marshak, K Matera, V Matveev, D P Méndez, M D Messier, H Meyer, T Miao, W H Miller, S R Mishra, R Mohanta, A Moren, L Mualem, M Muether, S Mufson, R Murphy, J Musser, J K Nelson, R Nichol, E Niner, A Norman, T Nosek, Y Oksuzian, A Olshevskiy, T Olson, J Paley, P Pandey, R B Patterson, G Pawloski, D Pershey, O Petrova, R Petti, S Phan-Budd, R K Plunkett, R Poling, B Potukuchi, C Principato, F Psihas, A Radovic, R A Rameika, B Rebel, B Reed, D Rocco, P Rojas, V Ryabov, K Sachdev, P Sail, O Samoylov, M C Sanchez, R Schroeter, J Sepulveda-Quiroz, P Shanahan, A Sheshukov, J Singh, J Singh, P Singh, V Singh, J Smolik, N Solomey, E Song, A Sousa, K Soustruznik, M Strait, L Suter, R L Talaga, M C Tamsett, P Tas, R B Thayyullathil, J Thomas, X Tian, S C Tognini, J Tripathi, A Tsaris, J Urheim, P Vahle, J Vasel, L Vinton, A Vold, T Vrba, B Wang, M Wetstein, D Whittington, S G Wojcicki, J Wolcott, N Yadav, S Yang, J Zalesak, B Zamorano, R Zwaska
Results are reported from an improved measurement of ν_{μ}→ν_{e} transitions by the NOvA experiment. Using an exposure equivalent to 6.05×10^{20} protons on target, 33 ν_{e} candidates are observed with a background of 8.2±0.8 (syst.). Combined with the latest NOvA ν_{μ} disappearance data and external constraints from reactor experiments on sin^{2}2θ_{13}, the hypothesis of inverted mass hierarchy with θ_{23} in the lower octant is disfavored at greater than 93% C.L. for all values of δ_{CP}.
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28643874/2-6-bis-diazaboryl-pyridine-a-superbasic-sterically-demanding-pyridine-ligand
#7
Tobias Böttcher, Daniel Himmel, Jan Schröder
Herein we present a convenient one-pot route to a sterically demanding superbasic pyridine. Functionalization of the 2,6-positions with the highly sigma-donating boryl-groups shifts the calculated gas phase basicity of the pyridine's nitrogen atom to 1012 kJ mol-1, which outperforms the 'proton sponge' 1,8-bis(dimethylamino)naphthalene (996 kJ mol-1). The diazaboryl groups are oriented orthogonal to the pyridine ring and do not block the N-position, resembling the geometry of commonly used N-heterocyclic carbenes...
June 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28558254/sensing-the-cold-trp-channels-in-thermal-nociception
#8
Nathaniel J Himmel, Daniel N Cox
No abstract text is available yet for this article.
May 30, 2017: Channels
https://www.readbyqxmd.com/read/28528086/cellulosic-ethanol-status-and-innovation
#9
REVIEW
Lee R Lynd, Xiaoyu Liang, Mary J Biddy, Andrew Allee, Hao Cai, Thomas Foust, Michael E Himmel, Mark S Laser, Michael Wang, Charles E Wyman
Although the purchase price of cellulosic feedstocks is competitive with petroleum on an energy basis, the cost of lignocellulose conversion to ethanol using today's technology is high. Cost reductions can be pursued via either in-paradigm or new-paradigm innovation. As an example of new-paradigm innovation, consolidated bioprocessing using thermophilic bacteria combined with milling during fermentation (cotreatment) is analyzed. Acknowledging the nascent state of this approach, our analysis indicates potential for radically improved cost competitiveness and feasibility at smaller scale compared to current technology, arising from (a) R&D-driven advances (consolidated bioprocessing with cotreatment in lieu of thermochemical pretreatment and added fungal cellulase), and (b) configurational changes (fuel pellet coproduction instead of electricity, gas boiler(s) in lieu of a solid fuel boiler)...
May 18, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28525928/-indicators-for-speech-comprehension-in-migrant-children-a-comparison-of-extreme-groups
#10
Christiane Kiese-Himmel, Herbert Poinstingl, Nicole von Steinbüchel
Objective Children with migrant background learning German as second language are frequently considered having problems in speech comprehension and speaking; nevertheless, it is very difficult to objectify that for young children. For this purpose risk-factors should be determined empirically. Material and Methods The study comprised 126 children from a developmental longitudinal study in 7 day-care centers in Frankfurt/M and Darmstadt. The sample was sorted into two extreme groups by their achievement in oral German language comprehension: criterion T-score ≥46=age appropriate (N=61) vs...
May 19, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28467174/nodular-typhlocolitis-heterakiasis-and-mesenchymal-neoplasia-in-a-ring-necked-pheasant-phasianus-colchicus-with-immunohistochemical-characterization-of-visceral-metastases
#11
Lauren Himmel, Rachel Cianciolo
A 9-y-old, male ring-necked pheasant ( Phasianus colchicus) was autopsied following euthanasia because of acute distress, recumbency, and dyspnea. The bird had experienced a protracted period of neuromuscular disease localized to the left sciatic nerve. Gross and histologic examination of the large intestine revealed intramural nodules predominantly comprised of atypical, whorling spindle cells with small cores of granulomatous inflammation centered on cross-sections of immature adult nematodes. The body structures of these metazoan organisms and clinical disease manifestation are consistent with Heterakis isolonche infection...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28452513/measurement-of-the-neutrino-mixing-angle-%C3%AE-_-23-in-nova
#12
P Adamson, L Aliaga, D Ambrose, N Anfimov, A Antoshkin, E Arrieta-Diaz, K Augsten, A Aurisano, C Backhouse, M Baird, B A Bambah, K Bays, B Behera, S Bending, R Bernstein, V Bhatnagar, B Bhuyan, J Bian, T Blackburn, A Bolshakova, C Bromberg, J Brown, G Brunetti, N Buchanan, A Butkevich, V Bychkov, M Campbell, E Catano-Mur, S Childress, B C Choudhary, B Chowdhury, T E Coan, J A B Coelho, M Colo, J Cooper, L Corwin, L Cremonesi, D Cronin-Hennessy, G S Davies, J P Davies, P F Derwent, S Desai, R Dharmapalan, P Ding, Z Djurcic, E C Dukes, H Duyang, S Edayath, R Ehrlich, G J Feldman, M J Frank, M Gabrielyan, H R Gallagher, S Germani, T Ghosh, A Giri, R A Gomes, M C Goodman, V Grichine, R Group, D Grover, B Guo, A Habig, J Hartnell, R Hatcher, A Hatzikoutelis, K Heller, A Himmel, A Holin, J Hylen, F Jediny, M Judah, G K Kafka, D Kalra, S M S Kasahara, S Kasetti, R Keloth, L Kolupaeva, S Kotelnikov, I Kourbanis, A Kreymer, A Kumar, S Kurbanov, K Lang, W M Lee, S Lin, J Liu, M Lokajicek, J Lozier, S Luchuk, K Maan, S Magill, W A Mann, M L Marshak, K Matera, V Matveev, D P Méndez, M D Messier, H Meyer, T Miao, W H Miller, S R Mishra, R Mohanta, A Moren, L Mualem, M Muether, S Mufson, R Murphy, J Musser, J K Nelson, R Nichol, E Niner, A Norman, T Nosek, Y Oksuzian, A Olshevskiy, T Olson, J Paley, P Pandey, R B Patterson, G Pawloski, D Pershey, O Petrova, R Petti, S Phan-Budd, R K Plunkett, R Poling, B Potukuchi, C Principato, F Psihas, A Radovic, R A Rameika, B Rebel, B Reed, D Rocco, P Rojas, V Ryabov, K Sachdev, P Sail, O Samoylov, M C Sanchez, R Schroeter, J Sepulveda-Quiroz, P Shanahan, A Sheshukov, J Singh, J Singh, P Singh, V Singh, J Smolik, N Solomey, E Song, A Sousa, K Soustruznik, M Strait, L Suter, R L Talaga, M C Tamsett, P Tas, R B Thayyullathil, J Thomas, X Tian, S C Tognini, J Tripathi, A Tsaris, J Urheim, P Vahle, J Vasel, L Vinton, A Vold, T Vrba, B Wang, M Wetstein, D Whittington, S G Wojcicki, J Wolcott, N Yadav, S Yang, J Zalesak, B Zamorano, R Zwaska
This Letter reports new results on muon neutrino disappearance from NOvA, using a 14 kton detector equivalent exposure of 6.05×10^{20} protons on target from the NuMI beam at the Fermi National Accelerator Laboratory. The measurement probes the muon-tau symmetry hypothesis that requires maximal θ_{23} mixing (θ_{23}=π/4). Assuming the normal mass hierarchy, we find Δm_{32}^{2}=(2.67±0.11)×10^{-3}  eV^{2} and sin^{2}θ_{23} at the two statistically degenerate values 0.404_{-0.022}^{+0.030} and 0...
April 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28267923/multifunctional-cellulolytic-enzymes-outperform-processive-fungal-cellulases-for-coproduction-of-nanocellulose-and-biofuels
#13
John M Yarbrough, Ruoran Zhang, Ashutosh Mittal, Todd Vander Wall, Yannick J Bomble, Stephen R Decker, Michael E Himmel, Peter N Ciesielski
Producing fuels, chemicals, and materials from renewable resources to meet societal demands remains an important step in the transition to a sustainable, clean energy economy. The use of cellulolytic enzymes for the production of nanocellulose enables the coproduction of sugars for biofuels production in a format that is largely compatible with the process design employed by modern lignocellulosic (second generation) biorefineries. However, yields of enzymatically produced nanocellulose are typically much lower than those achieved by mineral acid production methods...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28267425/book-review-atlas-of-histology-of-the-juvenile-rat-atlas-of-histology-of-the-juvenile-rat-parker-george-a-picut-catherine-a-editors-academic-press-elsevier-cambridge-ma-2016-150-hardcover-or-ebook-isbn-978-0-12-802682-3
#14
https://www.readbyqxmd.com/read/28262664/motor-neurons-control-blood-vessel-patterning-in-the-developing-spinal-cord
#15
Patricia Himmels, Isidora Paredes, Heike Adler, Andromachi Karakatsani, Robert Luck, Hugo H Marti, Olga Ermakova, Eugen Rempel, Esther T Stoeckli, Carmen Ruiz de Almodóvar
Formation of a precise vascular network within the central nervous system is of critical importance to assure delivery of oxygen and nutrients and for accurate functionality of neuronal networks. Vascularization of the spinal cord is a highly stereotypical process. However, the guidance cues controlling blood vessel patterning in this organ remain largely unknown. Here we describe a new neuro-vascular communication mechanism that controls vessel guidance in the developing spinal cord. We show that motor neuron columns remain avascular during a developmental time window, despite expressing high levels of the pro-angiogenic vascular endothelial growth factor (VEGF)...
March 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28251275/-patient-experiences-and-patient-centeredness-the-website-project-dipex-germany
#16
Martina Breuning, Gabriele Lucius-Hoene, Christina Burbaum, Wolfgang Himmel, Jürgen Bengel
Patient centeredness is a central concept in the treatment and rehabilitation of persons with chronic illness in Germany. There are various concepts of and approaches to patient centeredness, most of them developed from the perspective of health care research and the institutions. In terms of participation requirements, there has been a lack of understanding of the patient's perspective and experiences so far. In this article, the authors assume that the collection and analysis of patient experiences can improve patient participation and provide access to the experience of living and coping with an illness, including the patient's interactions with the health care system, their participation, and their preferences for participation...
March 1, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28245366/book-review-atlas-of-histology-of-the-juvenile-rat-atlas-of-histology-of-the-juvenile-rat-parker-george-a-picut-catherine-a-editors-academic-press-elsevier-cambridge-ma-2016-150-hardcover-or-ebook-isbn-978-0-12-802682-3
#17
https://www.readbyqxmd.com/read/28218800/hydrogen-atom-transfer-hat-initiated-by-intramolecular-ligand-metal-electron-transfer
#18
Hendrik Herrmann, Elisabeth Kaifer, Hans-Jörg Himmel
Hydrogen-atom transfer (HAT) is of key importance for several catalytic and biological processes, and provides an elegant access to C-H activation. In synthetic chemistry, a photoactivated metal complex is often employed to abstract an oxygen- or nitrogen-bound hydrogen, and the as-generated oxygen- or nitrogen-centered radical is the hydrogen-atom acceptor for HAT. Here, we report the first examples for HAT processes initiated by one-electron oxidation of urea azines. A further novelty is that the HAT-initiating oxidation can be realized by intramolecular ligand-metal electron transfer in copper(II)-urea azine complexes...
April 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28211142/a-stable-hexakis-guanidino-benzene-realization-of-the-strongest-neutral-organic-four-electron-donor
#19
Benjamin Eberle, Elisabeth Kaifer, Hans-Jörg Himmel
The growing demand for efficient batteries has stimulated the search for redox-active organic compounds with multistage redox behavior, as materials with large charge capacity. Herein we report the synthesis and properties of the first hexakis(guanidino)benzene derivative: a strong neutral organic electron donor with reversible multistage redox behavior and a record low redox potential for donation of four electrons. Detailed structural and spectroscopic characterization of three redox states (0, +2, and +4) reveal its unique electronic features...
March 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28207378/book-review-atlas-of-histology-of-the-juvenile-rat-atlas-of-histology-of-the-juvenile-rat-parker-george-a-picut-catherine-a-editors-academic-press-elsevier-cambridge-ma-2016-150-hardcover-or-ebook-isbn-978-0-12-802682-3
#20
keyword
keyword
118888
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"