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https://www.readbyqxmd.com/read/28950222/socioemotional-skills-between-12-and-30-months-of-age-on-chilean-children-when-do-the-competences-of-adults-matter
#1
Chamarrita Farkas, Claire D Vallotton, Katherine Strasser, María Pía Santelices, Erika Himmel
Due to the rapid growth in early socioemotional skills during the first three years of life, significant variations in socioemotional development begin early and increase with time. Family competences as sensitivity and mentalization, contribute to differences among children of the same age. This study examines whether the level of socioemotional skills is stable or changes between 12 and 30 months of age, and whether primary caregiver sensitivity and mentalization, as well as educational level, are associated with changes in the level of socioemotional skills...
September 23, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28942503/heterologous-expression-of-a-%C3%AE-d-glucosidase-in-caldicellulosiruptor-bescii-has-a-surprisingly-modest-effect-on-the-activity-of-the-exoproteome-and-growth-on-crystalline-cellulose
#2
Sun-Ki Kim, Daehwan Chung, Michael E Himmel, Yannick J Bomble, Janet Westpheling
Members of the genus Caldicellulosiruptor are the most thermophilic cellulolytic bacteria so far described and are capable of efficiently utilizing complex lignocellulosic biomass without conventional pretreatment. Previous studies have shown that accumulation of high concentrations of cellobiose and, to a lesser extent, cellotriose, inhibits cellulase activity both in vivo and in vitro and high concentrations of cellobiose are present in C. bescii fermentations after 90 h of incubation. For some cellulolytic microorganisms, β-D-glucosidase is essential for the efficient utilization of cellobiose as a carbon source and is an essential enzyme in commercial preparations for efficient deconstruction of plant biomass...
September 23, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28851921/the-multi-domain-caldicellulosiruptor-bescii-cela-cellulase-excels-at-the-hydrolysis-of-crystalline-cellulose
#3
Roman Brunecky, Bryon S Donohoe, John M Yarbrough, Ashutosh Mittal, Brian R Scott, Hanshu Ding, Larry E Taylor Ii, Jordan F Russell, Daehwan Chung, Janet Westpheling, Sarah A Teter, Michael E Himmel, Yannick J Bomble
The crystalline nature of cellulose microfibrils is one of the key factors influencing biomass recalcitrance which is a key technical and economic barrier to overcome to make cellulosic biofuels a commercial reality. To date, all known fungal enzymes tested have great difficulty degrading highly crystalline cellulosic substrates. We have demonstrated that the CelA cellulase from Caldicellulosiruptor bescii degrades highly crystalline cellulose as well as low crystallinity substrates making it the only known cellulase to function well on highly crystalline cellulose...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796933/from-an-easily-accessible-pentacarbonylcobalt-i-salt-to-piano-stool-cations-arene-co-co-2
#4
Stefan C Meier, Albina Holz, Alexei Schmidt, Daniel Kratzert, Daniel Himmel, Ingo Krossing
The facile synthesis of a pentacarbonyl cobalt(I) salt without the need for a superacid as solvent is presented. This salt, [Co(CO)5 ](+) [Al(OR(F) )4 ](-) {R(F) =C(CF3 )3 }, readily accessible on a multigram scale, undergoes substitution reactions with arenes yielding the hitherto unknown class of two-legged cobalt piano-stool complexes [(arene)Co(CO)2 ](+) with four different arene ligands. Such a substitution chemistry would have been impossible in superacid solution, as the arenes used would have been oxidized and/or protonated...
August 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28771843/inter-and-intramolecular-electron-transfer-in-copper-complexes-electronic-entatic-state-with-redox-active-guanidine-ligands
#5
David F Schrempp, Simone Leingang, Martin Schnurr, Elisabeth Kaifer, Hubert Wadepohl, Hans-Jörg Himmel
Fast and efficient electron transfer in blue copper proteins is realized by a structural harmonization between the Cu(I) and Cu(II) complex pair ("entatic state" model). Herein, we present now a Cu(I) /Cu(II) complex pair with redox-active guanidine ligands showing almost perfect match between both redox states. By modifying the ligand electron donor strength, the redox chemistry of the copper complex can be controlled to be either metal-centered or to cross the borderline to ligand-centered. This work is the first systematic study of complexes with redox-active ligands within the concept of the entatic state...
August 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28759144/multiple-metal-metal-bond-or-no-bond-the-electronic-structure-of-v2-o2
#6
Olaf Hübner, Hans-Jörg Himmel
Detailed knowledge of the electronic structure of vanadium oxide clusters provides the basis for understanding and tuning their significant catalytic properties. However, already for the simple four-atom V2 O2 molecule, there are contradictory reports in the literature regarding the electronic ground state and a possible vanadium-vanadium bond. We herein show through a combination of experimental (matrix isolation) studies and theoretical results that there is a multiple vanadium-vanadium bond in this benchmark vanadium oxide molecule...
July 31, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28738851/expression-and-secretion-of-fungal-endoglucanase-ii-and-chimeric-cellobiohydrolase-i-in-the-oleaginous-yeast-lipomyces-starkeyi
#7
Qi Xu, Eric P Knoshaug, Wei Wang, Markus Alahuhta, John O Baker, Shihui Yang, Todd Vander Wall, Stephen R Decker, Michael E Himmel, Min Zhang, Hui Wei
BACKGROUND: Lipomyces starkeyi is one of the leading lipid-producing microorganisms reported to date; its genetic transformation was only recently reported. Our aim is to engineer L. starkeyi to serve in consolidated bioprocessing (CBP) to produce lipid or fatty acid-related biofuels directly from abundant and low-cost lignocellulosic substrates. RESULTS: To evaluate L. starkeyi in this role, we first conducted a genome analysis, which revealed the absence of key endo- and exocellulases in this yeast, prompting us to select and screen four signal peptides for their suitability for the overexpression and secretion of cellulase genes...
July 24, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28722282/metal-free-nitrile-diboration-through-activation-by-an-electron-rich-diborane
#8
Markus Frick, Elisabeth Kaifer, Hans-Jörg Himmel
Diboration of unsaturated organic compounds is an extremely useful reaction in synthetic chemistry. Herein, we report the first diboration of a nitrile by an electron-rich diborane, mediated by an electrophilic borane. The reaction is metal-free, and all of the reagents are readily available.
September 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28670741/structural-mutagenic-and-in%C3%A2-silico-studies-of-xyloglucan-fucosylation-in-arabidopsis-thaliana-suggest-a-water-mediated-mechanism
#9
Breeanna R Urbanowicz, Vivek S Bharadwaj, Markus Alahuhta, Maria J Peña, Vladimir V Lunin, Yannick J Bomble, Shuo Wang, Jeong-Yeh Yang, Sami T Tuomivaara, Michael E Himmel, Kelley W Moremen, William S York, Michael F Crowley
The mechanistic underpinnings of the complex process of plant polysaccharide biosynthesis are poorly understood, largely because of the resistance of glycosyltransferase (GT) enzymes to structural characterization. In Arabidopsis thaliana, a glycosyl transferase family 37 (GT37) fucosyltransferase 1 (AtFUT1) catalyzes the regiospecific transfer of terminal 1,2-fucosyl residues to xyloglucan side chains - a key step in the biosynthesis of fucosylated sidechains of galactoxyloglucan. We unravel the mechanistic basis for fucosylation by AtFUT1 with a multipronged approach involving protein expression, X-ray crystallography, mutagenesis experiments and molecular simulations...
July 3, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28663545/towards-an-understanding-of-enhanced-biomass-digestibility-by-in-planta-expression-of-a-family-5-glycoside-hydrolase
#10
Bryon S Donohoe, Hui Wei, Ashutosh Mittal, Todd Shollenberger, Vladimir V Lunin, Michael E Himmel, Roman Brunecky
In planta expression of a thermophilic endoglucanase (AcCel5A) reduces recalcitrance by creating voids and other irregularities in cell walls of Arabidopsis thaliana that increase enzyme accessibility without negative impacts on plant growth or cell wall composition. Our results suggest that cellulose β-1-4 linkages can be cut sparingly in the assembling wall and that these minimal changes, made at the proper time, have an impact on plant cell wall recalcitrance without negative effects on overall plant development...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28654163/homo-and-heterobinuclear-cu-and-pd-complexes-with-a-bridging-redox-active-bisguanidino-substituted-dioxolene-ligand-electronic-structure-and-metal-ligand-electron-transfer
#11
David Fridolin Schrempp, Elisa Schneider, Elisabeth Kaifer, Hubert Wadepohl, Hans-Jörg Himmel
A new redox-active 4,5-bisguanidino-substituted o-benzoquinone ligand L is synthesized, which allows rational access to heterobinuclear complexes through the sequential coordination of two metals. In the examples discussed in this work, mononuclear Cu and Pd complexes are prepared in a first coordination step, and these complexes are then used as precursors to homobinuclear [Cu(II) -L(0) -Cu(II) ] and heterobinuclear [Pd(II) -L(0) -Cu(II) ] complexes. In the heterobinuclear complex, the Pd(II) is coordinated by the softer bisguanidine side of L and the Cu(II) by the harder dioxolene side (in line with the HSAB concept)...
June 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28650071/in-vivo-synergistic-activity-of-a-cazyme-cassette-from-acidothermus-cellulolyticus-significantly-improves-the-cellulolytic-activity-of-the-c-bescii-exoproteome
#12
Sun-Ki Kim, Daehwan Chung, Michael E Himmel, Yannick J Bomble, Janet Westpheling
The use of microbial cells to convert plant biomass directly to fuels and chemicals is referred to as consolidated bioprocessing (CBP). Members of the bacterial genus, Caldicellulosiruptor (Gram-positive, anaerobic hyperthermophiles) are capable of deconstructing plant biomass without enzymatic or chemical pretreatment. This is accomplished by the production and secretion of free, multi-domain enzymes that outperform commercial enzyme cocktails on some substrates. Here, we show that the exoproteome of Caldicellulosiruptor bescii may be enhanced by the heterologous expression of enzymes from Acidothermus cellulolyticus that act synergistically to improve sugar release from complex substrates; as well as improve cell growth...
November 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28644674/constraints-on-oscillation-parameters-from-%C3%AE-_-e-appearance-and-%C3%AE-_-%C3%AE-disappearance-in-nova
#13
P Adamson, L Aliaga, D Ambrose, N Anfimov, A Antoshkin, E Arrieta-Diaz, K Augsten, A Aurisano, C Backhouse, M Baird, B A Bambah, K Bays, B Behera, S Bending, R Bernstein, V Bhatnagar, B Bhuyan, J Bian, T Blackburn, A Bolshakova, C Bromberg, J Brown, G Brunetti, N Buchanan, A Butkevich, V Bychkov, M Campbell, E Catano-Mur, S Childress, B C Choudhary, B Chowdhury, T E Coan, J A B Coelho, M Colo, J Cooper, L Corwin, L Cremonesi, D Cronin-Hennessy, G S Davies, J P Davies, P F Derwent, R Dharmapalan, P Ding, Z Djurcic, E C Dukes, H Duyang, S Edayath, R Ehrlich, G J Feldman, M J Frank, M Gabrielyan, H R Gallagher, S Germani, T Ghosh, A Giri, R A Gomes, M C Goodman, V Grichine, R Group, D Grover, B Guo, A Habig, J Hartnell, R Hatcher, A Hatzikoutelis, K Heller, A Himmel, A Holin, J Hylen, F Jediny, M Judah, G K Kafka, D Kalra, S M S Kasahara, S Kasetti, R Keloth, L Kolupaeva, S Kotelnikov, I Kourbanis, A Kreymer, A Kumar, S Kurbanov, K Lang, W M Lee, S Lin, J Liu, M Lokajicek, J Lozier, S Luchuk, K Maan, S Magill, W A Mann, M L Marshak, K Matera, V Matveev, D P Méndez, M D Messier, H Meyer, T Miao, W H Miller, S R Mishra, R Mohanta, A Moren, L Mualem, M Muether, S Mufson, R Murphy, J Musser, J K Nelson, R Nichol, E Niner, A Norman, T Nosek, Y Oksuzian, A Olshevskiy, T Olson, J Paley, P Pandey, R B Patterson, G Pawloski, D Pershey, O Petrova, R Petti, S Phan-Budd, R K Plunkett, R Poling, B Potukuchi, C Principato, F Psihas, A Radovic, R A Rameika, B Rebel, B Reed, D Rocco, P Rojas, V Ryabov, K Sachdev, P Sail, O Samoylov, M C Sanchez, R Schroeter, J Sepulveda-Quiroz, P Shanahan, A Sheshukov, J Singh, J Singh, P Singh, V Singh, J Smolik, N Solomey, E Song, A Sousa, K Soustruznik, M Strait, L Suter, R L Talaga, M C Tamsett, P Tas, R B Thayyullathil, J Thomas, X Tian, S C Tognini, J Tripathi, A Tsaris, J Urheim, P Vahle, J Vasel, L Vinton, A Vold, T Vrba, B Wang, M Wetstein, D Whittington, S G Wojcicki, J Wolcott, N Yadav, S Yang, J Zalesak, B Zamorano, R Zwaska
Results are reported from an improved measurement of ν_{μ}→ν_{e} transitions by the NOvA experiment. Using an exposure equivalent to 6.05×10^{20} protons on target, 33 ν_{e} candidates are observed with a background of 8.2±0.8 (syst.). Combined with the latest NOvA ν_{μ} disappearance data and external constraints from reactor experiments on sin^{2}2θ_{13}, the hypothesis of inverted mass hierarchy with θ_{23} in the lower octant is disfavored at greater than 93% C.L. for all values of δ_{CP}.
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28643874/2-6-bis-diazaboryl-pyridine-a-superbasic-sterically-demanding-pyridine-ligand
#14
Jan Schröder, Daniel Himmel, Tobias Böttcher
Herein a convenient one-pot route to a sterically demanding superbasic pyridine is presented. Functionalization of the 2- and 6-positions with the strongly σ-donating boryl-groups shifts the calculated gas phase basicity of the pyridine nitrogen atom to 1012 kJ mol(-1) , which outperforms the "proton sponge" 1,8-bis(dimethylamino)naphthalene (996 kJ mol(-1) ). The diazaboryl groups are oriented orthogonally to the pyridine ring and do not block the N-position, which resembles the geometry of commonly used N-heterocyclic carbenes...
June 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28558254/sensing-the-cold-trp-channels-in-thermal-nociception
#15
Nathaniel J Himmel, Daniel N Cox
No abstract text is available yet for this article.
September 3, 2017: Channels
https://www.readbyqxmd.com/read/28528086/cellulosic-ethanol-status-and-innovation
#16
REVIEW
Lee R Lynd, Xiaoyu Liang, Mary J Biddy, Andrew Allee, Hao Cai, Thomas Foust, Michael E Himmel, Mark S Laser, Michael Wang, Charles E Wyman
Although the purchase price of cellulosic feedstocks is competitive with petroleum on an energy basis, the cost of lignocellulose conversion to ethanol using today's technology is high. Cost reductions can be pursued via either in-paradigm or new-paradigm innovation. As an example of new-paradigm innovation, consolidated bioprocessing using thermophilic bacteria combined with milling during fermentation (cotreatment) is analyzed. Acknowledging the nascent state of this approach, our analysis indicates potential for radically improved cost competitiveness and feasibility at smaller scale compared to current technology, arising from (a) R&D-driven advances (consolidated bioprocessing with cotreatment in lieu of thermochemical pretreatment and added fungal cellulase), and (b) configurational changes (fuel pellet coproduction instead of electricity, gas boiler(s) in lieu of a solid fuel boiler)...
May 18, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28525928/-indicators-for-speech-comprehension-in-migrant-children-a-comparison-of-extreme-groups
#17
Christiane Kiese-Himmel, Herbert Poinstingl, Nicole von Steinbüchel
Objective Children with migrant background learning German as second language are frequently considered having problems in speech comprehension and speaking; nevertheless, it is very difficult to objectify that for young children. For this purpose risk-factors should be determined empirically. Material and Methods The study comprised 126 children from a developmental longitudinal study in 7 day-care centers in Frankfurt/M and Darmstadt. The sample was sorted into two extreme groups by their achievement in oral German language comprehension: criterion T-score ≥46=age appropriate (N=61) vs...
October 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28467174/nodular-typhlocolitis-heterakiasis-and-mesenchymal-neoplasia-in-a-ring-necked-pheasant-phasianus-colchicus-with-immunohistochemical-characterization-of-visceral-metastases
#18
Lauren Himmel, Rachel Cianciolo
A 9-y-old, male ring-necked pheasant ( Phasianus colchicus) was autopsied following euthanasia because of acute distress, recumbency, and dyspnea. The bird had experienced a protracted period of neuromuscular disease localized to the left sciatic nerve. Gross and histologic examination of the large intestine revealed intramural nodules predominantly comprised of atypical, whorling spindle cells with small cores of granulomatous inflammation centered on cross-sections of immature adult nematodes. The body structures of these metazoan organisms and clinical disease manifestation are consistent with Heterakis isolonche infection...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28452513/measurement-of-the-neutrino-mixing-angle-%C3%AE-_-23-in-nova
#19
P Adamson, L Aliaga, D Ambrose, N Anfimov, A Antoshkin, E Arrieta-Diaz, K Augsten, A Aurisano, C Backhouse, M Baird, B A Bambah, K Bays, B Behera, S Bending, R Bernstein, V Bhatnagar, B Bhuyan, J Bian, T Blackburn, A Bolshakova, C Bromberg, J Brown, G Brunetti, N Buchanan, A Butkevich, V Bychkov, M Campbell, E Catano-Mur, S Childress, B C Choudhary, B Chowdhury, T E Coan, J A B Coelho, M Colo, J Cooper, L Corwin, L Cremonesi, D Cronin-Hennessy, G S Davies, J P Davies, P F Derwent, S Desai, R Dharmapalan, P Ding, Z Djurcic, E C Dukes, H Duyang, S Edayath, R Ehrlich, G J Feldman, M J Frank, M Gabrielyan, H R Gallagher, S Germani, T Ghosh, A Giri, R A Gomes, M C Goodman, V Grichine, R Group, D Grover, B Guo, A Habig, J Hartnell, R Hatcher, A Hatzikoutelis, K Heller, A Himmel, A Holin, J Hylen, F Jediny, M Judah, G K Kafka, D Kalra, S M S Kasahara, S Kasetti, R Keloth, L Kolupaeva, S Kotelnikov, I Kourbanis, A Kreymer, A Kumar, S Kurbanov, K Lang, W M Lee, S Lin, J Liu, M Lokajicek, J Lozier, S Luchuk, K Maan, S Magill, W A Mann, M L Marshak, K Matera, V Matveev, D P Méndez, M D Messier, H Meyer, T Miao, W H Miller, S R Mishra, R Mohanta, A Moren, L Mualem, M Muether, S Mufson, R Murphy, J Musser, J K Nelson, R Nichol, E Niner, A Norman, T Nosek, Y Oksuzian, A Olshevskiy, T Olson, J Paley, P Pandey, R B Patterson, G Pawloski, D Pershey, O Petrova, R Petti, S Phan-Budd, R K Plunkett, R Poling, B Potukuchi, C Principato, F Psihas, A Radovic, R A Rameika, B Rebel, B Reed, D Rocco, P Rojas, V Ryabov, K Sachdev, P Sail, O Samoylov, M C Sanchez, R Schroeter, J Sepulveda-Quiroz, P Shanahan, A Sheshukov, J Singh, J Singh, P Singh, V Singh, J Smolik, N Solomey, E Song, A Sousa, K Soustruznik, M Strait, L Suter, R L Talaga, M C Tamsett, P Tas, R B Thayyullathil, J Thomas, X Tian, S C Tognini, J Tripathi, A Tsaris, J Urheim, P Vahle, J Vasel, L Vinton, A Vold, T Vrba, B Wang, M Wetstein, D Whittington, S G Wojcicki, J Wolcott, N Yadav, S Yang, J Zalesak, B Zamorano, R Zwaska
This Letter reports new results on muon neutrino disappearance from NOvA, using a 14 kton detector equivalent exposure of 6.05×10^{20} protons on target from the NuMI beam at the Fermi National Accelerator Laboratory. The measurement probes the muon-tau symmetry hypothesis that requires maximal θ_{23} mixing (θ_{23}=π/4). Assuming the normal mass hierarchy, we find Δm_{32}^{2}=(2.67±0.11)×10^{-3}  eV^{2} and sin^{2}θ_{23} at the two statistically degenerate values 0.404_{-0.022}^{+0.030} and 0...
April 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28267923/multifunctional-cellulolytic-enzymes-outperform-processive-fungal-cellulases-for-coproduction-of-nanocellulose-and-biofuels
#20
John M Yarbrough, Ruoran Zhang, Ashutosh Mittal, Todd Vander Wall, Yannick J Bomble, Stephen R Decker, Michael E Himmel, Peter N Ciesielski
Producing fuels, chemicals, and materials from renewable resources to meet societal demands remains an important step in the transition to a sustainable, clean energy economy. The use of cellulolytic enzymes for the production of nanocellulose enables the coproduction of sugars for biofuels production in a format that is largely compatible with the process design employed by modern lignocellulosic (second generation) biorefineries. However, yields of enzymatically produced nanocellulose are typically much lower than those achieved by mineral acid production methods...
March 28, 2017: ACS Nano
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